Iba Toshiaki 射場敏明

… Alternative Names

IBA Toshiaki 射場敏明

射場敏明イバトシアキ

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Researcher Number	40193635
Other IDs
External Links
Affiliation (Current)	2025: 順天堂大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2008 – 2023: 順天堂大学, 医学部, 教授 1997 – 1998: 順天堂大学, 医学部, 講師 1996: 順天堂大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Basic Section 55060:Emergency medicine-related / Emergency medicine / General surgery Except Principal Investigator Basic Section 49050:Bacteriology-related / Bacteriology (including mycology) / Bacteriology (including Mycology)
Keywords	Principal Investigator 敗血症 / 多臓器障害 / 血管内皮細胞 / バイオマーカー / ミオグロビン / 横紋筋融解 / 熱中症 / ヒストン / プロテオーム解析 / アンチトロンビンIII … More / 血管内皮 / 多臓器不全 / 血管内皮細胞障害 / 活性化好中球 / 血管内炎症 / シスタチンC / 鉄関連タンパク質 / 急性尿細管障害 / 腎障害 / 尿細管細胞 / ヘモグロビン / cell death / endothelial cell / lactate dehydrogenase / hemopexin / myoglobin / hemoglobin / 血小板 / 遊離ヘム / ヘモペキシン / ヘム / 急性腎障害 / 重症度 / ヘパラン硫酸 / ペントラキシン3 / アンチトロンビン / シンデカン / グリコカリクス / 二次元電気泳動 / 凝固異常 / 補体 / 鉄代謝 / 凝固因子 / プロテオミクス / 血中マーカー / SAPS II / プロカルシトニン / インターロイキン6 / 重症度診断 / 細胞死 / pentraxin-3 / pentraxin 3 / protein C / nucleosome / histone / DAMPs / cell-death / sepsis / proteome / 敗血症性臓器障害 / 肝微小循環 / アンチトロンビン III / 微小循環障害 / 血管作動因子 / サイトカイン / 敗血症性多臓器障害 / 凝固・線溶機能異常 / エンドトキシン / 凝固・線溶機能 / 播種性血管内凝固 … More Except Principal Investigator 敗血症 / 抗菌ペプチド / LL-37 / 好中球 / alarmin / 生体防御ペプチド / 細胞外小胞 / エクトソーム / ectosome / エクソソーム / 翻訳後修飾 / 細胞死 / エンドトキシン / マクロファージ / 細胞老化 / senolysis / 老化細胞除去 / SASP / 老化細胞 / マイクロRNA / CXCR2 / FPR2 / CRAMP / lactoferrin / 抗菌活性分子 / 抗菌活性 / カルパイン / Ca2+シグナリング / マイクロベシクル / 生体防御ペプチドLL-37 / レポーターマウス / シグナル伝達経路 / 抗菌作用 / microparticle / cathelicidin / アラーミン / 転写因子 / O-GlcNAc化 / acetyl化 / 自然免疫 / 炎症 / LPS / acetylation / リポ多糖（LPS） / アセチル化 / PTM / 翻訳語修飾 / リポ多糖（LPS) / 感染防御・制御 / リポ多糖 / DAMPs / サイトカイン / NETs / Sirtuin（サーチュイン） / lipopolysaccharide / LPS (lipopolysaccharide) / sirtuin / Lipopolysaccharide / サーチュイン / カスパーゼ / ピロトーシス / alrmin / HMGB-1 / 血管内皮細胞 / アポトーシス Less

Regulation of the pathological condition of sepsis by focusing the senolytic activity of host defense peptide LL-37
- Principal Investigator
  
  長岡功
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49050:Bacteriology-related
- Research Institution
  Juntendo University
Search for the novel biomarker to evaluate the severity of heat-related illnessPrincipal Investigator
- Principal Investigator
  
  射場敏明
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55060:Emergency medicine-related
- Research Institution
  Juntendo University
Host defense peptide LL-37 modulates the pathogenesis of sepsis by inducing the release of exosomes
- Principal Investigator
  
  長岡功
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49050:Bacteriology-related
- Research Institution
  Juntendo University
Towards therapeutic application of neutrophil-secreted extracellular vesicles in sepsis
- Principal Investigator
  
  Kumagai Yumi
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49050:Bacteriology-related
- Research Institution
  Juntendo University
Assessment and treatment of acute renal failure targetting free-heme in rhabdomyolysisPrincipal Investigator
- Principal Investigator
  
  Iba Toshiaki
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55060:Emergency medicine-related
- Research Institution
  Juntendo University
Regulation of sepsis by alarmin that induces the release of ectosomes with antibacterial potential from neutrophils
- Principal Investigator
  
  Nagaoka Isao
- Project Period (FY)
  2017 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including mycology)
- Research Institution
  Juntendo University
Analysis of translational modifications of proteins involved in inflammatory signaling in sepsis
- Principal Investigator
  
  Murakami Taisuke
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including mycology)
- Research Institution
  Juntendo University
Evaluation of the severity of sepsis by proteomic analysisPrincipal Investigator
- Principal Investigator
  
  Iba Toshiaki
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Emergency medicine
- Research Institution
  Juntendo University
Roles of NETs and alarmins in the pathogenesis of sepsis
- Principal Investigator
  
  NAGAOKA ISAO
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including mycology)
- Research Institution
  Juntendo University
Proteomic analysis for the cell-death related prteins makes it possible to address the pathophysiology of sepisPrincipal Investigator
- Principal Investigator
  
  Iba Toshiaki
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Emergency medicine
- Research Institution
  Juntendo University
Evaluation of sirtuin roles in septic shock
- Principal Investigator
  
  MURAKAMI Taisuke
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Juntendo University
Modulation of a novel death, pyroptosis by alarmins in septic shock
- Principal Investigator
  
  NAGAOKA Isao
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Juntendo University
Modulation of host cell apoptosis during sepsis by alarmins
- Principal Investigator
  
  NAGAOKA Isao
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Juntendo University
敗血症性多臓器不全に対する凝固線溶機能調節の効果Principal Investigator
- Principal Investigator
  
  射場敏明
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  General surgery
- Research Institution
  Juntendo University
敗血症性多臓器不全に対する凝固線溶機能調節の効果Principal Investigator
- Principal Investigator
  
  射場敏明
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  General surgery
- Research Institution
  Juntendo University

[Book] 救急・集中治療最新ガイドライン2014-’152014
- Author(s)
  射場敏明
- Total Pages
  3
- Publisher
  総合医学社
- Data Source
  KAKENHI-PROJECT-25462831
[Book] 敗血症救命医療の最前線2014
- Author(s)
  射場敏明
- Total Pages
  7
- Publisher
  医薬ジャーナル
- Data Source
  KAKENHI-PROJECT-25462831
[Book] 救急・集中治療レビュー2014-’152014
- Author(s)
  射場敏明、三木隆弘
- Total Pages
  5
- Publisher
  総合医学社
- Data Source
  KAKENHI-PROJECT-25462831
[Journal Article] Thromboinflammation in acute injury: infections, heatstroke, and trauma.2024
- Author(s)
  Iba T, Helms J, Levi M, Levy JH
- Journal Title
  
  J Thromb Haemost
  
  Volume: 22 Issue: 1 Pages: 7-22
- DOI
  10.1016/j.jtha.2023.07.020
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K09191
[Journal Article] Thromboinflammation and microcirculation damage in heatstroke.2024
- Author(s)
  Iba T, Maier CL, Levi M, Levy JH
- Journal Title
  
  Minerva Med
  
  Volume: Jan Issue: 2
- DOI
  10.23736/s0026-4806.23.08919-x
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K09191
[Journal Article] Inflammation, coagulation, and cellular injury in heat-induced shock.2023
- Author(s)
  Iba T, Helms J, Levi M, Levy JH.
- Journal Title
  
  Inflamm Res.
  
  Volume: 44 Issue: 3 Pages: 101276-101276
- DOI
  10.1007/s00011-022-01687-8
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09424, KAKENHI-PROJECT-22K09191
[Journal Article] The role of platelets in heat-related illness and heat-induced coagulopathy.2022
- Author(s)
  Iba T, Helms J, Levi M, Levy JH.
- Journal Title
  
  Thromb Res
  
  Volume: S0049-3848 Pages: 00342-5
- DOI
  10.1016/j.thromres.2022.08.009
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K09191
[Journal Article] Heatstroke-induced coagulopathy: Biomarkers, mechanistic insights, and patient management.2022
- Author(s)
  Iba T, Connors JM, Levi M, Levy JH.
- Journal Title
  
  EClinicalMedicine.
  
  Volume: 44 Pages: 101276-101276
- DOI
  10.1016/j.eclinm.2022.101276
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09424
[Journal Article] Morphological Changes in Blood Cells in a Rat Model of Heatstroke: A Pilot Study.2022
- Author(s)
  Iba T, Sawada T, Kondo Y, Kondo K, Levy JH.
- Journal Title
  
  J Clin Med
  
  Volume: 17 Issue: 16 Pages: 4821-4821
- DOI
  10.3390/jcm11164821
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K09191
[Journal Article] Recent advances in the research and management of sepsis-associated DIC2021
- Author(s)
  Iba T, Connors JM, Nagaoka I, Levy JH
- Journal Title
  
  Int J Hematol
  
  Volume: 113 Issue: 1 Pages: 24-33
- DOI
  10.1007/s12185-020-03053-y
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08840, KAKENHI-PROJECT-20K07486
[Journal Article] Antimicrobial peptide LL-37 ameliorates a murine sepsis model via the induction of microvesicle release from neutrophils2020
- Author(s)
  Kumagai Y, Murakami T, Kuwahara-Arai, Iba T, Reich J, Nagaoka I
- Journal Title
  
  Innate Immun
  
  Volume: 26 Issue: 7 Pages: 565-579
- DOI
  10.1177/1753425920936754
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08840, KAKENHI-PROJECT-19K07562, KAKENHI-PROJECT-20K07486
[Journal Article] Newly developed recombinant antithrombin protects the endothelial glycocalyx in an endotoxin-induced rat model of sepsis2020
- Author(s)
  Iba T, Levy JH, Aihara K, Kadota K, Tanaka H, Sato K, Nagaoka I
- Journal Title
  
  Int J Mol Sci
  
  Volume: 22 Issue: 1 Pages: 176-176
- DOI
  10.3390/ijms22010176
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08840, KAKENHI-PROJECT-20K07486
[Journal Article] Advance in the Management of Sepsis-Induced Coagulopathy and Disseminated Intravascular Coagulation.2019
- Author(s)
  Iba T, Levy JH, Raj A, Warkentin TE.
- Journal Title
  
  J Clin Med.
  
  Volume: 8 Issue: 5 Pages: 728-728
- DOI
  10.3390/jcm8050728
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09424
[Journal Article] Protective effect of a newly developed fucose-deficient recombinant antithrombin against histone-induced endothelial damage.2018
- Author(s)
  Iba T, Hirota T, Sato K, Nagaoka I
- Journal Title
  
  International Journal of Hematology
  
  Volume: 107 Issue: 5 Pages: 528-534
- DOI
  10.1007/s12185-018-2402-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08789, KAKENHI-PROJECT-17K08840
[Journal Article] Protection of the endothelial glycocalyx by antithrombin in an endotoxin-induced rat model of sepsis.2018
- Author(s)
  Iba T, Levy JH, Hirota T, Hiki M, Sato K, Murakami T, Nagaoka I.
- Journal Title
  
  Thrombosis Research
  
  Volume: 171 Pages: 1-6
- DOI
  10.1016/j.thromres.2018.09.042
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08789, KAKENHI-PROJECT-17K08840
[Journal Article] Role of extracellular vesicles in the development of sepsis-induced coagulopathy2018
- Author(s)
  Iba Toshiaki、Ogura Hiroshi
- Journal Title
  
  Journal of Intensive Care
  
  Volume: 6 Issue: 1 Pages: 68-79
- DOI
  10.1186/s40560-018-0340-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K11421
[Journal Article] Antimicrobial cathelicidin peptide LL-37 induces NET formation and suppresses the inflammatory responses in a mouse septic model.2017
- Author(s)
  Hosoda H, Nakamura K, Hu Z, Tamura H, Reich J, Kuwahara-Arai K, Iba T, Tabe Y, Nagaoaka I
- Journal Title
  
  Molecular Medicine Reports
  
  Volume: 16 Issue: 4 Pages: 5618-5626
- DOI
  10.3892/mmr.2017.7267
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08789, KAKENHI-PROJECT-17K08840
[Journal Article] Neutrophil extracellular traps induce IL-1β production by macrophages in combination with lipopolysaccharide.2017
- Author(s)
  Hu Z, Murakami T, Tamura H, Reich J, Kuwahara-Arai K, Iba T, Tabe Y, Nagaoka I.
- Journal Title
  
  Int J Mol Med.
  
  Volume: in press Issue: 3 Pages: 549-558
- DOI
  10.3892/ijmm.2017.2870
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08653, KAKENHI-PROJECT-16K08789, KAKENHI-PROJECT-17K08840, KAKENHI-PROJECT-26460538
[Journal Article] The comparison of the protective effects of α- and β-antithrombin against vascular endothelial cell damage induced by histone in vitro.2017
- Author(s)
  Iba T, Sasaki T, Ohshima K, Sato K, Nagaoka I, Thachil J
- Journal Title
  
  TH Open
  
  Volume: 1 Issue: 01 Pages: e3-e10
- DOI
  10.1055/s-0037-1603926
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08789, KAKENHI-PROJECT-17K08840
[Journal Article] Evaluation of the effect of recombinant thrombomodulin on a lipopolysaccharide-induced murine sepsis model.2017
- Author(s)
  Takehara K, Murakami T, Kuwahara-Arai K, Iba T, Nagaoka I, Sakamoto K
- Journal Title
  
  Experimental and Therapeutic Medicine
  
  Volume: 13 Issue: 6 Pages: 2969-2974
- DOI
  10.3892/etm.2017.4308
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08789, KAKENHI-PROJECT-17K08840, KAKENHI-PROJECT-26460538
[Journal Article] Antimicrobial cathelicidin peptide LL-37 induces NET formation and suppresses the inflammatory responses in a mouse septic model2017
- Author(s)
  Hosoda H, Nakamura K, Hu Z, Tamura H, Reich J, Kuwahara-Arai K, Iba T, Tabe Y, Nagaoaka I
- Journal Title
  
  Mol Med Reports
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460538
[Journal Article] Human host defense cathelicidin peptide LL-37 enhances the lipopolysaccharide uptake by liver sinusoidal endothelial cells without cell activation.2016
- Author(s)
  Suzuki K, Murakami T, Hu Z, Tamura H, Kuwahara-Arai K, Iba T, Nagaoka I
- Journal Title
  
  J Immunol
  
  Volume: 196 Issue: 3 Pages: 1338-1347
- DOI
  10.4049/jimmunol.1403203
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26460538, KAKENHI-PROJECT-16K08789
[Journal Article] Physiological Levels of Pentraxin 3 and Albumin Attenuate Vascular Endothelial Cell Damage Induced by Histone H3 In Vitro.2016
- Author(s)
  Iba T, Hamakubo T, Nagaoka I, Sato K, Thachil J
- Journal Title
  
  Microcirculation
  
  Volume: 23 Issue: 3 Pages: 240-247
- DOI
  10.1111/micc.12269
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460538, KAKENHI-PROJECT-25220205, KAKENHI-PROJECT-25462831, KAKENHI-PROJECT-16K11421
[Journal Article] Glycocalyx Regulates the Intravascular Hemostasis2016
- Author(s)
  Iba T.
- Journal Title
  
  Juntendo Medical Journal
  
  Volume: 62 Issue: 4 Pages: 330-335
- DOI
  10.14789/jmj.62.330
- NAID
  130005433448
- ISSN
  2187-9737, 2188-2126
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K11421
[Journal Article] Present and future of anticoagulant therapy using antithrombin and thrombomodulin for sepsis‑associated disseminated intravascular coagulation: a perspective from Japan2016
- Author(s)
  Iba T, Jecko T
- Journal Title
  
  Int J Hematol
  
  Volume: 103 Issue: 3 Pages: 253-261
- DOI
  10.1007/s12185-015-1904-z
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11421
[Journal Article] DAMP and DIC: The role of extracellular DNA and DNA-binding proteins in the pathogenesis of DIC2016
- Author(s)
  Patricia C. Liaw, Takashi Ito, Toshiaki Iba, Jecko Thachil, Sacha Zeerleder
- Journal Title
  
  Blood Reviews
  
  Volume: 印刷中 Issue: 4 Pages: 257-261
- DOI
  10.1016/j.blre.2015.12.004
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05684, KAKENHI-PROJECT-25462831
[Journal Article] Potential diagnostic markers for disseminated intravascular coagulation of sepsis2016
- Author(s)
  Toshiaki Iba, Takashi Ito, Ikuro Maruyama, Bernd Jilma, Thorsten Brenner, Marcella C.A. Muller, Nicole P. Juffermans, Jecko Thachil
- Journal Title
  
  Blood Reviews
  
  Volume: 30 Issue: 2 Pages: 149-155
- DOI
  10.1016/j.blre.2015.10.002
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05684, KAKENHI-PROJECT-25462831, KAKENHI-PROJECT-15K15667, KAKENHI-PROJECT-26293385
[Journal Article] Antimicrobial cathelicidin peptide LL-37 inhibits the pyroptosis of macrophages and improves the survival of polybacterial septic mice.2016
- Author(s)
  Hu Z, Murakami T, Suzuki K, Tamura H, Reich J, Kuwahara-Arai K, Iba T, Nagaoka I
- Journal Title
  
  Int Immunol
  
  Volume: 28 Issue: 5 Pages: 245-253
- DOI
  10.1093/intimm/dxv113
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460538, KAKENHI-PROJECT-16K08789
[Journal Article] Kinetics of Circulating Damage-Associated Molecular Patterns in Sepsis.2015
- Author(s)
  Miki T, Iba T
- Journal Title
  
  Journal of Immunology Research
  
  Volume: 2015 Pages: 424575-424575
- DOI
  10.1155/2015/424575
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25462831
[Journal Article] The effect of plasma-derived activated protein C on leukocyte cell-death and vascular endothelial damage.2015
- Author(s)
  Iba T, Nagakari K.
- Journal Title
  
  Thrombosis Research
  
  Volume: 135 Issue: 5 Pages: 963-969
- DOI
  10.1016/j.thromres.2015.03.012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25462831
[Journal Article] The usefulness of antithrombin activity monitoring during antithrombin supplementation in patients with sepsis-associated disseminated intravascular coagulation.2015
- Author(s)
  Iba T, Saitoh D, Gando S, Thachil J.
- Journal Title
  
  Thrombosis Research
  
  Volume: 135 Issue: 5 Pages: 897-901
- DOI
  10.1016/j.thromres.2015.03.007
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25462831
[Journal Article] Heparins attenuated histone-mediated cytotoxicity in vitro and improved the survival in a rat model of histone-induced organ dysfunction.2015
- Author(s)
  Iba T, Hashiguchi N, Nagaoka I, Tabe Y, Kadota K, Sato K
- Journal Title
  
  Intensive Care Medicine Experimental
  
  Volume: 3 Issue: 1 Pages: 36-36
- DOI
  10.1186/s40635-015-0072-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26460538, KAKENHI-PROJECT-25462831
[Journal Article] Effect of hemoperfusion using polymyxin B-immobilized fibers on acute lung injury in a rat sepsis model.2014
- Author(s)
  Iba T, Nagaoka I, Yamada A, Nagayama M, Miki T.
- Journal Title
  
  Int J Med Sci
  
  Volume: 11 Issue: 3 Pages: 255-261
- DOI
  10.7150/ijms.6276
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590519, KAKENHI-PROJECT-25462831, KAKENHI-PROJECT-26460538
[Journal Article] Combination of antithrombin and recombinant thrombomodulin attenuates leukocyte-endothelial interaction and suppresses the increase of intrinsic damage-associated molecular patterns in endotoxemic rats.2014
- Author(s)
  Iba T, Miki T, Hashiguchi N, Yamada A, Nagaoka I
- Journal Title
  
  J Surg Res
  
  Volume: 187 Pages: 581-586
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460538
[Journal Article] Combination of antithrombin and recombinant thrombomodulin modulates neutrophil cell-death and decreases circulating DAMPs levels in endotoxemic rats.2014
- Author(s)
  Iba T, Miki T, Hashiguchi N, Tabe Y, Nagaoka I
- Journal Title
  
  Thromb Res
  
  Volume: 134 Pages: 169-173
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460538
[Journal Article] Anticoagulant therapy for sepsis-associated disseminated intravascular coagulation - The View from Japan.2014
- Author(s)
  Iba T, Gando S, Thachil J.
- Journal Title
  
  J Thromb Haemost
  
  Volume: E pub Issue: 7 Pages: 1010-1019
- DOI
  10.1111/jth.12596
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25462831
[Journal Article] Combination of antithrombin and recombinant thrombomodulin attenuates leukocyte-endothelial interaction and suppresses the increase of intrinsic damage-associated molecular patterns in endotoxemic rats.2014
- Author(s)
  Iba T, Miki T, Hashiguchi N, Yamada A, Nagaoka I.
- Journal Title
  
  J Surg Res
  
  Volume: 187 Issue: 2 Pages: 581-586
- DOI
  10.1016/j.jss.2013.10.058
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590519, KAKENHI-PROJECT-25462831
[Journal Article] Is the neutrophil a ‘prima donna’ in the procoagulant process during sepsis?2014
- Author(s)
  Iba T, Miki T, Hashiguchi N, Tabe Y, Nagaoka I.
- Journal Title
  
  Critical Care
  
  Volume: 8 Issue: 4 Pages: 230-237
- DOI
  10.1186/cc13983
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25462831, KAKENHI-PROJECT-26460538
[Journal Article] Antimicrobial cathelicidin peptide LL-37 inhibits the LPS/ATP-induced pyroptosis of macrophages by dual mechanism.2014
- Author(s)
  Hu Z, Murakami T, Suzuki K, Tamura H, Kuwahara-Arai K, Iba T, Nagaoka I
- Journal Title
  
  PLOS ONE
  
  Volume: 9
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26460538
[Journal Article] Neutrophil extracellular traps, damage-associated molecular patterns, and cell death during sepsis.2014
- Author(s)
  Iba T, Murai M, Nagaoka I, Tabe Y.
- Journal Title
  
  Acute Med Surg
  
  Volume: 1 Issue: 1 Pages: 2-9
- DOI
  10.1002/ams2.10
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590519
[Journal Article] Antimicrobial cathelicidin peptide LL-37 inhibits the LPS/ATP-induced pyroptosis of macrophages by dual mechanism.2014
- Author(s)
  Hu Z, Murakami T, Suzuki K, Tamura H, Kuwahara-Arai K, Iba T, Nagaoka I.
- Journal Title
  
  PLoS One
  
  Volume: 9 Issue: 1 Pages: e85765-e85765
- DOI
  10.1371/journal.pone.0085765
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590519
[Journal Article] Combination of antithrombin and recombinant thrombomodulin modulates neutrophil cell-death and decreases circulating DAMPs levels in endotoxemic rats.2014
- Author(s)
  Iba T, Miki T, Hashiguchi N, Tabe Y, Nagaoka I.
- Journal Title
  
  Thromb Res
  
  Volume: E pub Issue: 1 Pages: 169-173
- DOI
  10.1016/j.thromres.2014.04.015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25462831
[Journal Article] Neutrophil extracellular traps (NETs), damage-associated molecular patterns (DAMPs) and cell-death during sepsis.2014
- Author(s)
  Iba T, Murai M, Nagaoka I, Tabe Y
- Journal Title
  
  Acute Medicine & Surgery
  
  Volume: 1 Pages: 2-9
- NAID
  130004542349
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25462831
[Journal Article] Antimicrobial cathelicidin peptide LL-37 inhibits the LPS/ATP-induced pyroptosis of macrophages by dual mechanism2014
- Author(s)
  Hu Z, Murakami T, Suzuki K, Tamura H, Kuwahara-Arai K, Iba T, Nagaoka I
- Journal Title
  
  PLOS ONE
  
  Volume: 9(1)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590519
[Journal Article] The anticoagulant therapy for sepsis-associated disseminated intravascular coagulation.2013
- Author(s)
  Iba T, Nagaoka I, Boulat M.
- Journal Title
  
  Thromb Res
  
  Volume: 131 Issue: 5 Pages: 383-389
- DOI
  10.1016/j.thromres.2013.03.012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590519
[Journal Article] Neutrophil cell-death in response to infection and its relation to coagulation.2013
- Author(s)
  Iba T, Hashiguchi N, Nagaoka I, Tabe Y, Murai M.
- Journal Title
  
  J Intensive Care
  
  Volume: 1 Issue: 1
- DOI
  10.1186/2052-0492-1-13
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25462831
[Presentation] 生体防御ペプチドLL-37による抗菌活性を有する細胞外小胞の放出を介したマウス敗血症の病態改善2020
- Author(s)
  熊谷由美, 射場敏明, 長岡　功
- Organizer
  第7回日本細胞外小胞学会
- Data Source
  KAKENHI-PROJECT-17K08840
[Presentation] 生体防御ペプチドLL-37による抗菌活性を有する細胞外小胞の放出を介したマウス敗血症の病態改善2020
- Author(s)
  熊谷由美　射場敏明　長岡功
- Organizer
  第7回　日本細胞外小胞学会
- Data Source
  KAKENHI-PROJECT-19K07562
[Presentation] 生体防御ペプチドLL-37による抗菌活性を有する細胞外小胞の放出を介したマウス敗血症の病態改善2020
- Author(s)
  熊谷由美, 射場敏明, 長岡　功
- Organizer
  第7回日本細胞外小胞学会
- Data Source
  KAKENHI-PROJECT-20K07486
[Presentation] DIC and Vascular Endothelium.2019
- Author(s)
  Iba T
- Organizer
  The XXVII Congress of International Society on Thrombosis and Haemostasis
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09424
[Presentation] A Hemostasis Perspective on How to Mitigate Sepsis Mortality2018
- Author(s)
  Iba T
- Organizer
  64th Annual Meeting of the International Society on Thrombosis and Haemostasis
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11421
[Presentation] 好中球細胞外小胞の産生を介したLL-37によるマウス敗血症の病態改善.2018
- Author(s)
  熊谷由美, 村上泰介, 桒原京子, 射場敏明, 長岡　功
- Organizer
  第101回日本細菌学会関東支部総会
- Data Source
  KAKENHI-PROJECT-17K08840
[Presentation] 血清プロテオミクス法による敗血症進行メカニズムの解明と機械学習を用いた診断法の開発2017
- Author(s)
  山口駿太、氏本慧、澤田好秀、三木隆弘、服部晋也、射場敏明、林宣宏
- Organizer
  第22回日本血管病理研究会
- Data Source
  KAKENHI-PROJECT-16K11421
[Presentation] 今日の敗血症性DIC診療2017
- Author(s)
  射場敏明
- Organizer
  第44回日本集中治療医学会学術集会
- Place of Presentation
  ロイトン札幌
- Year and Date
  2017-03-09
- Data Source
  KAKENHI-PROJECT-16K11421
[Presentation] 敗血症性DICの病態とマネージメント2016
- Author(s)
  射場敏明
- Organizer
  第44回日本救急医学会総会・学術集会
- Place of Presentation
  新高輪プリンスホテル
- Year and Date
  2016-11-17
- Invited
- Data Source
  KAKENHI-PROJECT-16K11421
[Presentation] DIC研究における最近の動向2016
- Author(s)
  射場敏明
- Organizer
  第43回日本集中治療医学会学術集会
- Place of Presentation
  神戸国際展示場
- Year and Date
  2016-02-11
- Data Source
  KAKENHI-PROJECT-25462831
[Presentation] Neutralizers of histones and DAMPS in DIC2016
- Author(s)
  Iba T.
- Organizer
  The International Society on Thrombosis and Hemostasis 62nd SSC
- Place of Presentation
  Montpellier
- Year and Date
  2016-05-25
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11421
[Presentation] Circulating Histones and coagulation disorder2016
- Author(s)
  Iba T.
- Organizer
  The 8th Congress of the International Federation of Shock Societies
- Place of Presentation
  Tokyo Dome Hotel
- Year and Date
  2016-10-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11421
[Presentation] Circulating Damage-associated Molecular Patterns play major roles in the development of coagulation disorder in infectious diseases2016
- Author(s)
  Iba T
- Organizer
  第80回日本循環器病学会
- Place of Presentation
  仙台国際会議場
- Year and Date
  2016-03-18
- Invited
- Data Source
  KAKENHI-PROJECT-25462831
[Presentation] 感染症における自然免疫と凝固反応2015
- Author(s)
  射場敏明
- Organizer
  第16回日本検査血液学会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2015-07-12
- Data Source
  KAKENHI-PROJECT-25462831
[Presentation] A novel mechanism for the human host defense peptide LL-37-Induced mast cell degranulation.2015
- Author(s)
  Suzuki K, Murakami T, Moribayashi T, Nagaoka I
- Organizer
  48Th Annual Meeting of the Society for Leukocyte Biology
- Place of Presentation
  Hilton North Raleigh, NC, USA
- Year and Date
  2015-09-27
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460538
[Presentation] 重症敗血症とDIC2015
- Author(s)
  射場敏明
- Organizer
  第37回日本血栓止血学会学術集会
- Place of Presentation
  甲府総合市民会館
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-25462831
[Presentation] Where to use thrombomodulin and antithrombin in DIC?2015
- Author(s)
  Iba T
- Organizer
  XXV Congress of the International Society on Thrombosis and Haemostasis
- Place of Presentation
  Tronto
- Year and Date
  2015-06-20
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25462831
[Presentation] Anticoagulant therapy for sepsis-associated disseminated intravascular coagulation - The View from Japan.2014
- Author(s)
  Iba-T
- Organizer
  International Journal of Thrombosis and Haemostasis
- Place of Presentation
  Milwaukee
- Invited
- Data Source
  KAKENHI-PROJECT-25462831
[Presentation] LPSで誘導される血管内皮細胞のアポトーシスに対するヒト抗菌ペプチドLL-37の抑制効果2010
- Author(s)
  鈴木香,栞原京子,射場敏明,山倉文幸,田村弘志,村上泰介,細田浩司,長岡功
- Organizer
  第57回毒素シンポジウム予稿集(60-62)
- Place of Presentation
  長浜
- Data Source
  KAKENHI-PROJECT-20590456
[Presentation] Cathelicidinファミリー抗菌ペプチドLL-37はLPSで誘導される血管内皮細胞のアポトーシスを抑制する2009
- Author(s)
  鈴木香,渋沢謙太郎,栞原京子,射場敏明,山倉文幸,田村弘志,長岡功
- Organizer
  生化学81:200,396,第82回日本生化学会大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-20590456
[Presentation] 重症感染症におけるNETsの役割と凝固異常
- Author(s)
  射場敏明
- Organizer
  第36回日本血栓止血学会
- Place of Presentation
  京都
- Year and Date
  2015-05-29 – 2015-05-31
- Data Source
  KAKENHI-PROJECT-25462831
[Presentation] 血清プロテオミクス法による敗血症重症度マーカーの検索
- Author(s)
  氏本慧、三木隆弘、Thanai Paxton、米澤貴之、鄭雄一、射場敏明、長岡功、林宣宏
- Organizer
  第37回日本分子生物学会
- Place of Presentation
  横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-25462831
[Presentation] 敗血症DICの病態と自然免疫
- Author(s)
  射場敏明
- Organizer
  第38回日本分子生物学会
- Place of Presentation
  甲府
- Year and Date
  2015-05-22 – 2015-05-23
- Data Source
  KAKENHI-PROJECT-25462831

1. NAGAOKA Isao (60164399)

# of Collaborated Projects: 9 results

# of Collaborated Products: 27 results
2. KUWAHARA Kyoko (10167976)

# of Collaborated Projects: 4 results

# of Collaborated Products: 10 results
3. HAYASHI Nobuhiro (80267955)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
4. Kumagai Yumi (90277591)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
5. SUZUKI Kaori (90631929)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
6. MURAKAMI Taisuke (40384135)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. TABE Yoko (70306968)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
8. HU Zhongshuang

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
9. 伊藤隆史

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
10. 丸山征郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Iba Toshiaki 射場 敏明

IBA Toshiaki 射場 敏明

射場 敏明 イバ トシアキ

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Search for the novel biomarker to evaluate the severity of heat-related illnessPrincipal Investigator

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Assessment and treatment of acute renal failure targetting free-heme in rhabdomyolysisPrincipal Investigator

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Evaluation of the severity of sepsis by proteomic analysisPrincipal Investigator

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Proteomic analysis for the cell-death related prteins makes it possible to address the pathophysiology of sepisPrincipal Investigator

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敗血症性多臓器不全に対する凝固線溶機能調節の効果Principal Investigator

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Iba Toshiaki 射場敏明

IBA Toshiaki 射場敏明

射場敏明イバトシアキ