TODA Katsumi 戸田勝巳

Researcher Number	40197893
External Links
Affiliation *help	2015 – 2018 : 高知大学, 教育研究部医療学系基礎医学部門, 准教授 2013 – 2014 : 高知大学, 教育研究部医療学系, 准教授 2012 : 高知大学, 教育研究部医療系, 准教授 2008 – 2011 : 高知大学, 教育研究部・医療学系, 准教授 2008 : 高知大学, 教育研究部医療学系, 准教授 … More
Review Section/Research Field	Principal Investigator Pathological medical chemistry / Experimental pathology / Environmental physiology(including physical medicine and nutritional physiology) / General medical chemistry Except Principal Investigator Gastroenterology / Eating habits, studies on eating habits / Pathological medical chemistry / Gastroenterology / General medical chemistry
Keywords	Principal Investigator アロマターゼ / エストロゲン / 転写制御 / 分子生物学 / 遺伝子改変マウス / シトクロームP450 / ノックアウトマウス / 精子形成 / フィブレート / 細胞内小胞リサイクル … More Except Principal Investigator NASH / 肝細胞癌 / エストロゲン / 肥満 / NASH動物モデル / マイクロインジェクション / インスリン抵抗性 / 脂肪肝 / estrogen / cDNA / 肝臓学 / MTP / モノクローナル抗体 / ノックアウトマウス / Monoclonal Antibody / IL-6 / 糖尿病合併症 / PPAR-α / 食品 / cyp19 / ADP-ribosylation / 抗糖尿病合併症 / a new assay method / AGE / 肝発癌 / ポリADPーリボース / 遺伝子多型 / ANIMAL MODEL / 健康と食生活 / genomicDNAクロ-ニング / α-fetoprotein / アロマタ-ゼ / COMPUTED TOMOGRAPHY / cDNAクロ-ニング / 遺伝子発現制御 / ポリADPリボース合成酵素 / MC4R / 内分泌撹乱物質 / Genomic DNA cloning / 肝硬変 / 核局在シグナル / Crystalography / Fatty acid / OBESITY / AFP / Pー450 / ADP-リボシル化酵素 / aromatase / 脂肪酸β酸化 / KO mouse / insulin resistance / STEATOHEPATITIS / 脂肪肝炎 / cDNAクローニング / ビタミンB6 / 染色体マッピング / 発現 / genomic DNA / 非アルコール性脂肪肝炎 / リパーゼ / トランスフォーメイション / 酸化ストレス / PLATELET / fatty liver / ArKO / genomic DNAクロ-ニング / NAFLD / 非アルコール性脂肪肝炎(NASH) / マイクロアレイ / biohazard estrogen / ADPーリボシル化酵素 / PPAR / 内分泌攪乱物質 / 結晶解析 / 糖新生 / FERRITIN / PPAR-alpha / クロマチン蛋白 / Melanocortin receptor / ADPーリボース / ピリドキサミン / ＭＣ４Ｒ / Microinjection / 非アルコール性脂肪性肝疾患 / モノクロ-ナル抗体 / cDNA cloning / genomicDNA / Beta-oxidation Less

自然肝発癌するNASHモデルマウスでのPPAR-αを介した発癌抑止の分子機構Ongoing
- Principal Investigator
  
  西原利治
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Kochi University
Regulatory mechanisms of ovulation by estrogenPrincipal Investigator
- Principal Investigator
  
  Toda Katsumi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Environmental physiology(including physical medicine and nutritional physiology)
- Research Institution
  Kochi University
Suppression of alpha-fetoprotein related hepatocellular proliferation and hepatocellular carcinogenesis in nonalcoholic steatohepatitis
- Principal Investigator
  
  SAIBARA Toshiji
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Kochi University
Screening of foods with anti-diabetic-complications function and elucidation of their functionality and mechanism of the function
- Principal Investigator
  
  YAGI Toshiharu
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Eating habits, studies on eating habits
- Research Institution
  Kochi University
Mechanisms involved in spontaneous development of hepatocellular carcinoma in mouse model of non-alcoholic steatohepatitis
- Principal Investigator
  
  SAIBARA Toshiji
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Kochi University
Charactrization of a single nucleotide polymorphism that determine the capacity of fatty acid beta-oxidation and its 3D-conformation
- Principal Investigator
  
  SAIBARA Toshiji
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Kochi University
精巣におけるエストロゲンの生理機能の解析Principal Investigator
- Principal Investigator
  
  戸田勝巳
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Kochi University
Investigation in the mechanisms involved in the development of nonalcoholic steatohepatitis and its clinical application
- Principal Investigator
  
  SAIBARA Toshiji
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Kochi University
Prevention /reinstatement of obesity and fatty-liver resulted from estrogen-insufficiency by exercisePrincipal Investigator
- Principal Investigator
  
  TODA Katsumi
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  KOCHI MEDICAL SCHOOL
Development of noninvasive procedure for diagnosis of NASH and of therapeutic strategy
- Principal Investigator
  
  SAIBARA Toshiji
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Kochi medical School
A new detection system for artificial synthetic steroid like compound using KO mouse lacking estrogen.
- Principal Investigator
  
  SHIZUTA Yutaka
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Institution
  Kochi Medical School
エストロゲン合成酵素遺伝子の発現制御Principal Investigator
- Principal Investigator
  
  戸田勝己
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  高知医科大学
エストロゲン合成酵素の遺伝子発現制御Principal Investigator
- Principal Investigator
  
  戸田勝巳
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  高知医科大学
アロマタ-ゼPー450の遺伝子構造と発現制御
- Principal Investigator
  
  SHIZUTA Yutaka
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  高知医科大学
モノクローナル抗体によるポリADPリボース合成酵素の生理的役割の解析
- Principal Investigator
  
  宇城啓至
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  高知医科大学
Regulation of Gene Expression by (ADP-ribosyl)ation Reaction
- Principal Investigator
  
  SHIZUTA Yutaka
- Project Period (FY)
  1988 – 1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Kochi Medical School
細胞がん化におけるポリADPーリボース合成酵素遺伝子の役割
- Principal Investigator
  
  静田裕
- Project Period (FY)
  1987
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  高知医科大学

All 2016 2015 2014 2012 2010 2008 2007 2006 2005 2004

All Journal Article

[Journal Article] Patatin-like phospholipase domain-containing protein 3 is involved in hepatic fatty acid and triglyceride metabolism through X-box binding protein 1 and modulation of endoplasmic reticulum stress in mice．2016
- Author(s)
  Ochi T, Munekage K, Ono M, Higuchi T, Tsuda M, Hayashi Y, Okamoto N, Toda K, Sakamoto S, Oben JA, Saibara T
- Journal Title
  
  Hepatol Res
  
  Volume : - Pages : 584-592
- DOI
  10.1111/hepr.12587
- Peer Reviewed / Int'l Joint Research / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K09010, KAKENHI-PROJECT-26461010, KAKENHI-PROJECT-26461011, KAKENHI-PROJECT-25460999, KAKENHI-PROJECT-15K09009, KAKENHI-PROJECT-16K19351, KAKENHI-PROJECT-25460315, KAKENHI-PROJECT-25460371
[Journal Article] Characterization of Ovarian Responses to Equine Chorionic Gonadotropin of Aromatase-Deficient Mice With or Without 17β-Estradiol Supplementatio2016
- Author(s)
  Katsumi Toda, Yoshihiro Hayashi, Masafumi Ono, Toshiji Saibara
- Journal Title
  
  Endocrinology
  
  Volume : 157 Pages : 2093-2103
- DOI
  10.1210/en.2015-1701
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25460315, KAKENHI-PROJECT-26461011, KAKENHI-PROJECT-15K09009, KAKENHI-PROJECT-15K09010
[Journal Article] Co-administration of insulin with a gonadotropin partly improves ovulatory responses of estrogen-deficient mice2015
- Author(s)
  Katsumi Toda, Yoshihiro Hayashi, Masafumi Ono, Toshiji Saibara
- Journal Title
  
  Molecular and Cellular Endocrinology
  
  Volume : 411 Pages : 177-186
- DOI
  10.1016/j.mce.2015.04.027
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25460315
[Journal Article] Aromatase-null mice expressing enhanced green fluorescent2014
- Author(s)
  Toda, K., Hayashi, Y., Yamashita, A., Okabe, M., Ono, M., and Saibara, T.
- Journal Title
  
  Transgenic Res
  
  Volume : 23 Pages : 293-302
- DOI
  10.1007/s11248-013-9771-y
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24240066, KAKENHI-PROJECT-24590981, KAKENHI-PROJECT-25460315, KAKENHI-PROJECT-25460999, KAKENHI-PROJECT-26461010, KAKENHI-PROJECT-26461011, KAKENHI-PROJECT-23590979
[Journal Article] Regional difference in sex steroid action on formation of morphological sex differences in the anteroventral periventricular nucleus and principal nucleus of the bed nucleus of the stria terminalis2014
- Author(s)
  Kanaya M, Tsuda M., Sagoshi S, Nagata K, Morimoto C, Thu CK, Today K, Kato S, Ogawa S, Tsukahara S
- Journal Title
  
  PLoS ONE
  
  Volume : 9
- DOI
  10.1371/journal.pone.0112616
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-23240057, KAKENHI-PROJECT-25460315, KAKENHI-PROJECT-25670114
[Journal Article] Abnormality in expression levels of gluconeogenesis-related genes by high-dose supplementation with pyridoxamine in mice2012
- Author(s)
  H. T. V. Do, K. Toda, T. Saibara, T. Yagi
- Journal Title
  
  International Journal for Vitamin and Nutrition Research
  
  Volume : (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21300278
[Journal Article] 1 7β-Estradiol is critical for the pr eovulatory induction of prostaglandi n E2 synthesis in mice2012
- Author(s)
  Toda K, Ono M, Yuhki K, Ushikubi F, and Saibara T.
- Journal Title
  
  Molecular and Cellular Endocrinology
  
  Volume : 362 Pages : 176-182
- DOI
  10.1016/j.mce.2012.06.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590294, KAKENHI-PROJECT-23590979, KAKENHI-PROJECT-24590981
[Journal Article] Impact of ovarian sex steroids on ovulation andovulatory gene induction in aromatase-null mice.2012
- Author(s)
  Toda K, Hayashi Y, Ono M, Saibara T
- Journal Title
  
  Endocrinology
  
  Volume : 153 Pages : 386-394
- DOI
  10.1210/en.2011-1462
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590849, KAKENHI-PROJECT-23590979, KAKENHI-PROJECT-24590981
[Journal Article] Deletion of tumor necrosis factor-α receptor type 1 exacerbates insulin resistance and hepatic steatosis in aromatase knot kout mice2010
- Author(s)
  Toda K
- Journal Title
  
  Biochim Biophys Acta 1801
  
  Pages : 655-664
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590849
[Journal Article] Deletion of tumor necrosis factor-alpha receptor type 1 exacerbates insulin resistance and hepatic steatosis in aromatase knockout mice2010
- Author(s)
  Toda K, Hayashi Y, Saibara T
- Journal Title
  
  Biochim Biophys Acta
  
  Volume : 1801 Pages : 655-664
- DOI
  10.1016/j.bbalip.2010.03.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590849
[Journal Article] Deletion of tumor necrosis factor-α receptor type 1 exacerbates insulin resistance and hepatic steatosis in aromatase knockout mice.2010
- Author(s)
  Toda K, Hayashi Y, Saibara T
- Journal Title
  
  Biochim Biophys Acta
  
  Volume : 1801 Pages : 655-664
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590849
[Journal Article] Preserved tissue-structure of efferent ductules in aromatase deficient mice.2008
- Author(s)
  Toda K, Okada T, Hayashi Y, Saibara T.
- Journal Title
  
  J. Endocrinol 199
  
  Pages : 137-146
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590772
[Journal Article] Expression of fascin-1, an actin-bundling protein, in migrating hepatoblasts during rat liver development.2008
- Author(s)
  Hayashi Y. Toda K, Saibara T, Okamoto S, et al.
- Journal Title
  
  Cell Tissue Res 334
  
  Pages : 219-226
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590772
[Journal Article] Expression of fascin-1, an actin-bundling protein, in migrating hepatoblasts during rat liver development2008
- Author(s)
  Hayashi Y, Toda K, Saibara T, Okamoto S, Osanai M, Enzan H, Lee GH
- Journal Title
  
  Cell Tissue Res. 334
  
  Pages : 219-226
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590772
[Journal Article] Preserved tissue-structure of efferent ductules in aromatase deficient mice2008
- Author(s)
  Toda K, Okada T, Hayashi Y, Saibara T.
- Journal Title
  
  J Endocrinol 199
  
  Pages : 137-146
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590772
[Journal Article] 内臓脂肪性肥満と肝庇護療法2007
- Author(s)
  戸田勝已
- Journal Title
  
  Bioclinica 22
  
  Pages : 683-686
- Data Source
  KAKENHI-PROJECT-17590349
[Journal Article] Assessment of anti-estrogenic activity of tamoxifen in trans genic mice expressing an enhanced green fluorescent protein gene regulated by estrogen response element2006
- Author(s)
  Y. Hayashi, K Toda., T. Saibara, T. Okada, H. Enzan
- Journal Title
  
  Biochemica et Biophysica Acta 1760
  
  Pages : 164-171
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590349
[Journal Article] Estrogen and androgen play distinct roles in bone turnover in male mice before and after reaching sexual maturity2006
- Author(s)
  C. Matsumoto, M. Inada, K Toda, C. Miyaura.
- Journal Title
  
  Bone 38
  
  Pages : 220-226
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590349
[Journal Article] Expression of the estrogen-inducible EGFP gene in aromatase-null mice reveals differential tissue-responses to estrogenic compounds2005
- Author(s)
  K Toda, Y. Hayashi, T. Okada, K. Morohashi, T. Saibara
- Journal Title
  
  Molecular and Cellular Endocrinology 229
  
  Pages : 119-126
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590349
[Journal Article] Expression of the estrogen-inducible EGFP gene in aromatase-null mice reveals differential tissue-responses to estrogenic compounds2005
- Author(s)
  戸田勝巳
- Journal Title
  
  Molecular and Cellular Endocrinology 229
  
  Pages : 119-126
- Data Source
  KAKENHI-PROJECT-17590349
[Journal Article] Expression of the estrogen-inducible EGFP gene in aromatase-null mice reveals differential tissue responses to estrogenic compounds.2005
- Author(s)
  Toda K
- Journal Title
  
  Mol Cell Endocrinol. 14
  
  Pages : 119-126
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590600
[Journal Article] Aromatase-knockout mouse carrying an estrogen-inducible enhanced green fluorescent protein gene facilitates detection of estrogen actions in vivo.2004
- Author(s)
  Toda K, et al.
- Journal Title
  
  Endocrinology 145
  
  Pages : 1880-1888
- Data Source
  KAKENHI-PROJECT-16590600
[Journal Article] Expression of the estrogen- inducible EGFP gene in aromatase-null mice reveals differential tissue response to estrogenic compounds.2004
- Author(s)
  K.Toda, et al.
- Journal Title
  
  Mol Cell Endocrinol 14
  
  Pages : 119-126
- Data Source
  KAKENHI-PROJECT-16590600

1. SAIBARA Toshiji (60145125)

# of Collaborated Projects : 6results

# of Collaborated Products : 11results
2. SHIZUTA Yutaka (50025631)

# of Collaborated Projects : 4results

# of Collaborated Products : 0results
3. 宇城啓至 (10151854)

# of Collaborated Projects : 3results

# of Collaborated Products : 0results
4. ONO Masafumi (70304681)

# of Collaborated Projects : 2results

# of Collaborated Products : 5results
5. AKISAWA Naoaki (00322280)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
6. TAKAHASHI Masaya (80380335)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
7. YAGI Toshiharu (90110759)

# of Collaborated Projects : 1results

# of Collaborated Products : 1results
8. OCHI Tsunehiro (30617840)

# of Collaborated Projects : 1results

# of Collaborated Products : 1results
9. MUNEKAGE Kensuke (60617843)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
10. KUGE Hideaki (70304673)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
11. SHIRAISHI Motonari (80216184)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
12. OGAWA Yoshihiro (90152397)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
13. 黒崎知博 (50178125)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
14. 山本泰猛 (90117036)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
15. 白石行正 (80019570)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
16. 光内康弘 (60219673)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
17. 耕崎拓大 (00332833)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
18. 水田洋 (70527605)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
19. Okamoto Nobuto

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
20. Higuchi Takuma

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
21. OKABE Masaru

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
22. OGAWA Sonoko

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
23. 坂本修士

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
24. 塚原伸治

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
25. 結城幸一

# of Collaborated Projects : 0results

# of Collaborated Products : 1results

TODA Katsumi 戸田 勝巳

Research Projects

Research Products

Co-Researchers

自然肝発癌するNASHモデルマウスでのPPAR-αを介した発癌抑止の分子機構Ongoing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Regulatory mechanisms of ovulation by estrogenPrincipal Investigator

Principal Investigator

Project Period (FY)

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Research Field

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Principal Investigator

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精巣におけるエストロゲンの生理機能の解析Principal Investigator

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Principal Investigator

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Prevention /reinstatement of obesity and fatty-liver resulted from estrogen-insufficiency by exercisePrincipal Investigator

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エストロゲン合成酵素遺伝子の発現制御Principal Investigator

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エストロゲン合成酵素の遺伝子発現制御Principal Investigator

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TODA Katsumi 戸田勝巳