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IMAZAKI Fumio  今関 文夫

ORCIDConnect your ORCID iD *help
Researcher Number 40223325
Other IDs
Affiliation (based on the past Project Information) *help 2015 – 2017: 千葉大学, 総合安全衛生管理機構, 教授
2011: 千葉大学, 大学院・医学研究院腫瘍内科学, 准教授
2007 – 2011: 千葉大学, 大学院・医学研究院, 准教授
2006: Chiba University, Graduate School of Medcine・Department of Medicine and Clinical Oncology, Assistant Professor, 医学部附属病院, 講師
2006: 千葉大学, 大学院医学研究院, 講師 … More
2001 – 2005: Chiba University, Graduate School of Medicine, Lecturer, 大学院・医学研究院, 講師
1997 – 2000: CHIBA UNIVERSITY,FACULTY OF MEDICINE,LECTURER, 医学部, 講師
1996: 千葉大学, 医学部・付属病院, 講師
1996: 千葉大学, 医学部・附属病院, 講師
1994 – 1995: 千葉大学, 医学部附属病院, 助手
1993 – 1995: 千葉大学, 医学部・附属病院, 助手
1994: 千葉大学, 医学部付属病院, 助手
1992: 千葉大学, 医学部(病), 助手
1990 – 1992: 千葉大学, 医学部附属病院, 助手
1991: Chiba University, assistant, 医学部, 助手 Less
Review Section/Research Field
Principal Investigator
Gastroenterology / Gastroenterology
Except Principal Investigator
Gastroenterology / Gastroenterology / Epidemiology and preventive medicine
Keywords
Principal Investigator
肝細胞癌 / Southern blot hybridization / Polymerase chain reaction / hepatocellular carcinoma / CpG island / 5-aza-2'deoxycytidine / mRNA / DNA chip / cDNA array / chronic hepatitis … More / TRAP assay / telomere / telomerase / メチル化 / Clonality / Hepatocellular carcinoma / トランスジェニックマウス / DNA methylation / cDNA microarray / Aza-C / CpGアイランド / DNAメチル化 / cDNAマイクロアレイ / suppression subtractive hybridization / transgenic mouse / HCV core protein / 細胞増殖 / 細胞周期 / Fasシグナル伝達系 / HCVコアタンパク / C型肝炎ウイルス / Northern blotting / C型慢性肝炎 / DNAチップ / サブトラクション法 / C型肝炎ウイルスコア蛋白 / Suppression subtractive hybridization / トランスジェニック マウス / HCV core蛋白 / ultrasonography guided liver biopsy / Telomere長 / Telomerase活性 / 慢性肝疾患 / chronis hepatitis / ultrasonegraphy guided liven biopsy / uotrasonography guided liver biopsy / Ultrasonically guided thin-needle biopsy / Methylation / Phosphoglycerate kinase gene / PCR法 / サザンブロットハイブリダイゼーション / HPRT遺伝子 / PGK遺伝子 / クローナリティ / 超音波映像下穿刺 / phosphoglycerate kinase遺伝子 / Loss of heterozygosity / Direct nucleotide sequencing / Anti-oncogene / p53 gene / restriction fragment length polymorphism(RFLP) / polymerase chain reaction(PCR) / p53 / ヘテロ接合性の消失 / 直接塩基配列決定法 / 癌抑制遺伝子 / p53遺伝子 / 非アルコール性脂肪性肝炎 / トランスジェニックウス / アンドロジェン受容体 / シグナル伝達 / 脂質 / アンドロジェン受容体トランスジェニックマウス … More
Except Principal Investigator
劇症肝炎 / Hepatitis B virus / B型肝炎ウイルス / AP-1 / NFkB / アポトーシス / SRE / HAV-VP3 / PCR / HBV DNA / 塩基配列決定 / A型肝炎 / 変異 / A型肝炎ウイルス / HBV-DNA / B型肝炎ウィルス / mutation / HLA / Interferon / HCV RNA / Hepatitis C virus / 遺伝子 / C型肝炎ウイルス / 慢性肝炎 / 急性肝炎 / C型肝炎ウィルス / 脱メチル化剤 / マイクロアレイ / 大学 / 結核検診 / IFN-γ Release Assay / IGRA / 胸部X線検査 / 健康診断 / 大学生 / 結核 / tumor suppressor gene / demethylating agent / anti-cancer agent / transcriptional regulation / DNA methylation / epigenetic disorder / gastric cancer / hepatocellular carcinoma / 癌 / 動物モデル / 抗がん剤 / 発現制御 / DNAメチル化 / エピジェネティック異常 / 消化器癌 / Lamivudine / Mutation / Ribavirin / ラミブジン / リバビリン / インターフェロン / C型肝炎 / B型肝炎 / OVAL CELL / GENE EXPRESSION / OSTEOPONTIN / DNA MICROARRAY / PROTEIN SYNTHESIS / LIVER REGENERATION / FULMINANT HEPATITIS / FLIP / FAS / サイトカイン / SNP解析 / DNAチップ / IGFBP1 / オーバル細胞 / 遺伝子発現 / osteopontin / DNAマイクロアレイ / 蛋白合成 / 肝再生 / STRUCTURAL PROTEIN / LUCIFERASE ASSAY / STONAL TRANSDUCTlON / NONSTRUCTURAL PROTEIN / HEPATITIS AVIRUS / HEPATITIS A / 弱毒化ウイルス / ルシフェラーゼ アッセイ / 構造蛋白 / ルシフェラーゼアッセイ / シグナル伝達 / 非構造蛋白 / ALU-HBV / Fusion protein / HBx gene / Integration / Hepatitis C Virus / Hepatocellular Carcinoma / Alu-HBV / fusion蛋白 / HBX / 分子機構 / 発癌 / 組み込み / 肝癌 / Hepatis A / sequence / fulminant hepatitis / Hepatitis A virus / ウイルス変異 / 塩基配列 / 劇症可燃 / CAT actiity / Core promoter / Enhancer 2 / コアプロモーター / HBV‐DNA / CAT活性 / コアープロモーター / エンハンサー領域 / fulminant / hepatitis / wild type / core gene / hepatitis B virus / TCR / PreーC変異株 / 劇性肝炎 / Mutant / HBV / 劇症 / 肝炎 / 野生株 / 変異株 / Core遺伝子 / HBウイルス / Chronic hepatitis / Acute hepatitis / Primer / Synthetic DNA / Polymerase chain reaction / ポリメラ-ゼ・チェイン・リアクション / HCVーRNA / インタ-フェロン / プライマ- / 合成DNA / HCDーRNA / ポリメラ-ゼ・チェイン・リアクション法 / エピジェネティク / マイクロRN / トランスフェクション / 培養細胞 / 細胞増殖能 / 発現解析 / 異常メチル化 / エピジェネティクス / マイクロRNA Less
  • Research Projects

    (17 results)
  • Research Products

    (8 results)
  • Co-Researchers

    (25 People)
  •  Designing matrix of tuberculosis screening for various Japanese universities.

    • Principal Investigator
      URUMA Reiko
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Epidemiology and preventive medicine
    • Research Institution
      Chiba University
  •  Analysis of nonalcoholic fatty liver using androgen receptor transgenic mousePrincipal Investigator

    • Principal Investigator
      IMAZEKI Fumio
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Chiba University
  •  Analysis of the relationship between epigenetic disorder, micro RNA in gastroenterological cancer

    • Principal Investigator
      YOKOSUKA Osamu
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      Chiba University
  •  Procaine has anti-proliferative effect and functions as an inhibitor of DNA methylation in human hepatocellular carcinoma and gastric cancer

    • Principal Investigator
      FUKAI Kenichi
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Chiba University
  •  Analysis of Viral and host factors influencing the pathophysiology and effect of therapy of pesisitent hepatitis virus infection

    • Principal Investigator
      YOKOSUKA Osamu
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Chiba University
  •  STUDIES ON HOST FACTORS RELATED TO FULMINANT HEPATITIS

    • Principal Investigator
      YOKOSUKA Osamu
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      CHIBA UNIVERSITY
  •  Genome-wide screen for hepermethylated genes in hepatocellular carcinomaPrincipal Investigator

    • Principal Investigator
      IMAZEKI Fumio
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Chiba University
  •  FUNCTIONAL ROBES OF HEPATITIS A VIRUS NONSTRUCTURAL PROTEINS IN SIGNAL TRANSDUCTION

    • Principal Investigator
      YOKOSUKA Osamu
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      CHIBA UNIVERSITY
  •  Functional analysis of HCV core protein using HCV core transgenic mousePrincipal Investigator

    • Principal Investigator
      IMAZEKI Fumio
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Chiba University
  •  HBV DNA integration and expression of HBx messages in HCC

    • Principal Investigator
      YOKOSUKA Osamu
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Chiba University
  •  ANALYSES OF HEPATITIS A VIRUS GENOME FROM PATIENTS WITH FULMINANT TYPE A HEPATITIS

    • Principal Investigator
      YOKOSUKA Osamu
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      CHIBA UNIVERSITY
  •  Analysis of telomerase activity and telomere length in various liver diseasesPrincipal Investigator

    • Principal Investigator
      IMAZEKI Fumio
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Chiba University
  •  ANALYSIS OF MUTATIONS IN HEPATITIS B VIRUS ENHANCER 2/CORE PROMOTER ANT THEIR FUNCTIONAL ROLES IN HEPATITIS B

    • Principal Investigator
      YOKOSUKA Osamu
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      CHIBA UNIBERSITY
  •  Analysis of clonality in hepatocellular carcinomaPrincipal Investigator

    • Principal Investigator
      IMAZEKI Fumio
    • Project Period (FY)
      1993 – 1994
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Chiba University
  •  Investigation of the Mechanism of Fulminant and Severe Hepatitis Correlated with Hepatitis B Virus Mutations

    • Principal Investigator
      OMATA Masao
    • Project Period (FY)
      1991 – 1993
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      University of Tokyo
      Chiba University
  •  Analysis of p53 anti-oncogene in hepatocellular carcinomaPrincipal Investigator

    • Principal Investigator
      IMAZEKI Fumio
    • Project Period (FY)
      1991 – 1992
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Chiba University
  •  Detection of hepatitis C virus RNA by sensitive PCR method

    • Principal Investigator
      YOKOSUKA Osamu
    • Project Period (FY)
      1990 – 1991
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Chiba University

All 2018 2017 2016 2010 2008 2007

All Journal Article Presentation

  • [Journal Article] 大学生に対するInterferon-Gamma Release Assay(IGRA)による結核検診の試み2018

    • Author(s)
      潤間励子、今井千恵、鍋田満代、岩倉かおり、千勝浩美、 土屋美香、生稲直美、 太和田暁之、大渓俊幸、今関文夫
    • Journal Title

      CAMPUS HEALTH

      Volume: 55 Pages: 68-68

    • Data Source
      KAKENHI-PROJECT-15K08727
  • [Journal Article] Involvement of interleukin-6 and androgen receptor signaling in pancreatic cancer2010

    • Author(s)
      Okitsu K, Kanda T, Imazeki F, Yonemitsu Y, Ray RB, Chang C, Yokosuka O
    • Journal Title

      Genes Cancer

      Volume: 1巻 Pages: 859-867

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590828
  • [Journal Article] Down-regulation of hedgehoginteracting protein through genetic ,, epigenetic alterations in human hepatocellular carcinoma2008

    • Author(s)
      多田素久、今関文夫、横須賀收, 他10
    • Journal Title

      Clin Cancer Res 14(12)

      Pages: 3768-76

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390195
  • [Journal Article] genes up-regulated by the demethylating agent, 5-aza- 2' deoxycytidine, in esophageal squamous cell carcinoma2008

    • Author(s)
      新井誠人、今関文夫、横須賀收, 他6名
    • Journal Title

      Oncol Rep 20(2)

      Pages: 405-12

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390195
  • [Presentation] 大学生に対するInterferon-Gamma Release Assay(IGRA)による結核検診の試み2017

    • Author(s)
      潤間励子、今井千恵、鍋田満代、岩倉かおり、千勝浩美、 土屋美香、生稲直美、 太和田暁之、大渓俊幸、今関文夫
    • Organizer
      第55回全国大学保健管理研究集会
    • Data Source
      KAKENHI-PROJECT-15K08727
  • [Presentation] 大学における結核検診の実態調査2016

    • Author(s)
      潤間励子、今井千恵、生稲直美、岩倉かおり、鍋田満代、千勝浩美、近藤妙子、横地紀子、土屋美香、吉田智子、太和田暁之、大渓俊幸、今関文夫
    • Organizer
      第54回全国大学保健管理研究集会
    • Place of Presentation
      大阪市
    • Year and Date
      2016-10-05
    • Data Source
      KAKENHI-PROJECT-15K08727
  • [Presentation] 大腸癌由来培養細胞において脱メチル化剤投与により発現上昇したマイクロRNAの解析2008

    • Author(s)
      田中健史、新井誠人、今関文夫、横須賀收
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-28
    • Data Source
      KAKENHI-PROJECT-19390195
  • [Presentation] 肝癌細胞株におけるエピジェネティク異常とマイクロRNAの関わりの検討2007

    • Author(s)
      新井誠人、今関文夫、横須賀收
    • Organizer
      第43回日本肝臓学会総会
    • Place of Presentation
      東京
    • Year and Date
      2007-05-31
    • Data Source
      KAKENHI-PROJECT-19390195
  • 1.  YOKOSUKA Osamu (90182691)
    # of Collaborated Projects: 14 results
    # of Collaborated Products: 4 results
  • 2.  FUKAI Kenichi (60361432)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 3.  ARAI Makoto (30396684)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 3 results
  • 4.  OMATA Masao (90125914)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 5.  TAGAWA Masami (90261916)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 6.  KAWAI Sigenobu (10311606)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 7.  TOKUHISA Takeshi (20134364)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 8.  江畑 稔樹 (20280919)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 9.  TADA Minoru
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 10.  SHIRATORI Yasushi (70196624)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  URUMA Reiko (80546945)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 12.  神田 達郎 (20345002)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  巽 浩一郎 (10207061)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  MATSUMURA Masayuki
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  NOSE Haruhiko
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  HONDA Arata
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  IMAI Chie
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 18.  YOSHIDA Tomoko
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 19.  IKUINA Naomi
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 20.  IWAKURA Kaori
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 21.  NABETA Mituyo
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 22.  CHIKATU Hiromi
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 23.  KONDO Taeko
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 24.  細田 和彦
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  藤原 慶一
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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