ZHANG Danqing 張丹青

… Alternative Names

張丹青チョウタンセイ

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Researcher Number	40296877
External Links
Affiliation (based on the past Project Information) *help	2010 – 2012: 順天堂大学, 医学部, 助教 2007: Juntendo University, SCHOOL OF MEDICINE, ASSISTANT PROFESSOR 2006: 順天堂大学, 医学部, 助手 2003 – 2004: 順天堂大学, 医学部, 助手 2001: Juntendo Univ., Dept. Pathol., Instructor, 医学部, 助手 1998: 順天堂大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Laboratory animal science Except Principal Investigator Immunology / 内科学一般
Keywords	Principal Investigator Erc / ノックアウトマウス / GPIアンカー蛋白 / Tsc2遺伝子 / Carcinogenesis / knockout mouse / GPI anchor protein / Tsc2 gene / Mesothelin gene / Erc遺伝子 … More / 発がん / Mesothelin遺伝子 / Intreagenic recombination / H-2 congenic mice / E molecules / MNC class II / New zealand mice / Systemic lupus erthematosus (SLE) / recombinantマウス / congenicマウス / Class II / MHC / NewZealandマウス / intragenic recombination / H-2 congenicマウス / E分子 / MHC Class II / New Zealandマウス / 全身性エリテマトーデス(SLE) / シグナル伝達 / Erc/mesothelin … More Except Principal Investigator H-2 recombination / MHC class II / 全身性エリテマトーデス / suppressor T cells / H-2-congenic mouse / I-E molecule / I-A molecule / systemic lupus erythematosus / ヘテロ接合性 / H-2-congeuicマウス / 抑制性T細胞 / H-2-congenicマウス / H-2recombination / I-E分子 / I-A分子 / MHC classII / CAT gene / affinity selection / Ig variable region gene / somatic mutation / autoantibody / IgG anti-DNA antibody / Natural antibody / SLE / 抗体可変領域遺伝子 / CAT遺伝子 / 親和性成熟 / 体細胞突然変異 / 抵抗可変領域遺伝子 / 自己抗体 / 自然抗体 / IgG抗DNA抗体 / 量的形質遺伝子座(QTL) / H-2 / マイクロサテライトDNA / B-1細胞 / prolactin / 位置的候補遺伝子 / New Zealand Whiteマウス / 自己免疫疾患 / B細胞性慢性リンパ性白血病 Less

The mechanism of loss of Erc gene ameliorates renal carcinogenesis and modulates integrin related pathwayPrincipal Investigator
- Principal Investigator
  
  ZHANG Danqing
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory animal science
- Research Institution
  Juntendo University
The functional analysis of Erc gene encoding GPI anchor proteinPrincipal Investigator
- Principal Investigator
  
  ZHANG Danqing
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory animal science
- Research Institution
  Juntendo University
The role of MHC sub-region in autoimmune susceptibility and suppressor CD8 T cellsPrincipal Investigator
- Principal Investigator
  
  ZHANG Danqing
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory animal science
- Research Institution
  JUNTENDO UNIVERSITY
Mechanism for MHC class II E region-linked autoimmune suppression.
- Principal Investigator
  
  HIROSE Sachiko
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  JUNTENDO UNIVERSITY
新しいB細胞性慢性リンパ性白血病の責任遺伝子の同定
- Principal Investigator
  
  濱野慶朋
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  内科学一般
- Research Institution
  Juntendo University
Studies on mechanism of pathogenic autoantibody production using CAT-transgenic autoimmune-prone mice
- Principal Investigator
  
  HIROSE Sachiko
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Juntendo University

All 2013 2012 2011 2010 2007 2006 2004

All Journal Article Presentation Patent

[Journal Article] Tuberin activates and controls the distribution of Rac1 viaassociation with p62 and ubiquitinthrough the mTORC1 signaling pathway2013
- Author(s)
  Okura H, Kobayashi T, Zhang D, Hino O, et al
- Journal Title
  
  Int J Oncol
  
  Volume: 2 Pages: 5-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500389
[Journal Article] Deficiency of the Erc/mesothelin gene ameliorates renal cazcinogenesis in Tsc2 knockout mice.2011
- Author(s)
  Zhang D, et al.
- Journal Title
  
  Cancer Science
  
  Volume: (Epubに掲載)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500389
[Journal Article] Deficiency of the Erc/mesothelin gene ameliorates renal carcinogenesis in Tsc2 knockout mice2011
- Author(s)
  Zhang D, Kobayashi T, Hino O, et al
- Journal Title
  
  Cancer Sci
  
  Volume: 102(4) Issue: 4 Pages: 720-7
- DOI
  10.1111/j.1349-7006.2011.01846.x
- NAID
  10029291977
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500389, KAKENHI-PROJECT-23510244
[Journal Article] Serine 62 is a phosphorylation site in folliculin, the Birt-Hogg-Dubegene product2010
- Author(s)
  Wang L, Kobayashi T, Zhang D, Hino O, et al
- Journal Title
  
  FEBS Lett
  
  Volume: 584(1) Issue: 1 Pages: 39-43
- DOI
  10.1016/j.febslet.2009.11.033
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500389
[Journal Article] Genetic dissection of vasculitis, myeloperoxidase-specific antineurtophil cytoplasmic autoantibody production, and related traits in spontaneous crescentic glomerulonephritis-forming/kinjoh mice.2006
- Author(s)
  Hamano Y, Tsukamoto K, Abe M, Sun G, Zhang D, et al.
- Journal Title
  
  J Immunol. 176・6
  
  Pages: 3662-3673
- Data Source
  KAKENHI-PROJECT-18500330
[Journal Article] コラーゲン誘導関節炎の発症に及ぼす抗体遺伝子の影響2004
- Author(s)
  趙京元, 張丹青, 黒澤尚, 広瀬幸子
- Journal Title
  
  順天堂医学 50
  
  Pages: 383-391
- NAID
  110004299052
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15500303
[Journal Article] The contribution of Igh allotype to the development of collagen-induced arthritis. (Article in Japanese)2004
- Author(s)
  Zhao J, Zhang D, Kurosawa H, Hirose S
- Journal Title
  
  Juntendo Med J. 50
  
  Pages: 383-391
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15500303
[Journal Article] コラーゲン誘導関節炎の発症に及ぼす抗体遺伝子の影響2004
- Author(s)
  趙京元, 張丹青, 黒澤尚, 広瀬幸子
- Journal Title
  
  順天堂医学 50.4
  
  Pages: 383-391
- NAID
  110004299052
- Data Source
  KAKENHI-PROJECT-15500303
[Journal Article] Transgene-mediated hyper-expression of IL-5 inhibits autoimmune disease but increases the risk of B cell chronic lymphocytic leukemia in a model of murine lupus.2004
- Author(s)
  Wen X, Zhang D, Kikuchi Y, et al.
- Journal Title
  
  Eur J Immunol. 34
  
  Pages: 2740-2749
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15500303
[Journal Article] Dissection of the role of MHC class II A and E genes in autoimmune susceptibility in murine lupus models with intragenic recombination.2004
- Author(s)
  Zhang D, Fujio K, Jiang Y, et al.
- Journal Title
  
  Proc Natl Acad Sci USA 101
  
  Pages: 13838-13843
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15500303
[Journal Article] Dissection of the role of MHC class II A and E genes in autoimmune susceptibility in murine lupus models with intragenic recombination.2004
- Author(s)
  Zhang D, Fujio K, Jiang Y, et al.
- Journal Title
  
  Proc.Natl.Acad.Sci.USA 101.32
  
  Pages: 13838-13843
- Data Source
  KAKENHI-PROJECT-15500303
[Journal Article] Dissection of the role of MHC class II A and E genes in autoimmune susceptibility in murine lupus models with intragenic recombination.2004
- Author(s)
  Zhang D, Fujio K, Jiang Y, et al.
- Journal Title
  
  Proc Natl Acad Sci USA. 101
  
  Pages: 13838-13843
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15500303
[Journal Article] Transgene-mediated hyper-expression of IL-5 inhibits autoimmune disease but increases the risk of B cell chronic lymphocytic leukemia in a model of murine lupus.2004
- Author(s)
  Wen X, Zhang D, Kikuchi Y, et al.
- Journal Title
  
  Eur.J.Immunol 34
  
  Pages: 2740-2749
- Data Source
  KAKENHI-PROJECT-15500303
[Patent] 関節リウマチを自然発症する疾患モデルマウス及びこのマウスを使用した関節リウマチの予防・治療薬のスクリーニング方法2004
- Inventor(s)
  小橋(張) 丹青
- Industrial Property Rights Holder
  順天堂大学, 日本SLC
- Filing Date
  2004-04-23
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15500303
[Presentation] Reduced the phosphorylation of epidermal growth factor (EGF) receptor in Erc-deficient renal tumor cells of Tsc2 KO mice.2012
- Author(s)
  小橋（張）丹青，ら
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  ロイトン札幌，札幌
- Data Source
  KAKENHI-PROJECT-22500389
[Presentation] Loss of Erc/mesothelin gene reduced the phosphorylation of EGFR and modulates PI3K-Akt pathway in renal tumor cells of Tsc2 KO mice.2012
- Author(s)
  小橋（張）丹青，ら
- Organizer
  第26回モロシヌス研究会
- Place of Presentation
  東京大学弥生講堂，東京
- Data Source
  KAKENHI-PROJECT-22500389
[Presentation] Loss of Erc/mesothelin gene decreased the growth of renal tumors in Tsc2 KO mice and modulates PI3K-Akt pathway2011
- Author(s)
  Zhang D, et al
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜(横浜)
- Year and Date
  2011-12-14
- Data Source
  KAKENHI-PROJECT-22500389
[Presentation] Enhancement of cell adhesion by Erc/mesothelin through modulation of PI3K-Akt pathway in Tsc2 KO mice renal tumor cells2011
- Author(s)
  Zhang D, et al
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場(名古屋)
- Year and Date
  2011-10-03
- Data Source
  KAKENHI-PROJECT-22500389
[Presentation] Loss of Erc/mesothelin gene decreased the growth of renal tumors in Tsc2 knockout mice.2010
- Author(s)
  Zhang D, et al.
- Organizer
  The 4th AFLAS Congress Meeting
- Place of Presentation
  台北国際会議中心(台湾)
- Year and Date
  2010-11-09
- Data Source
  KAKENHI-PROJECT-22500389
[Presentation] Erc/mesothelin gene regulates the growth of renal tumors in Tsc2 KO mice and modulates integrin pathway.2010
- Author(s)
  Zhang D, et al.
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪国際会議場(大阪)
- Year and Date
  2010-09-22
- Data Source
  KAKENHI-PROJECT-22500389
[Presentation] Loss of Erc gene ameliorates renal carcinogenesis and modulates integrin path-way in Tsc2 KO mouse.2010
- Author(s)
  Zhang D, et al.
- Organizer
  第99回日本病理学会総会
- Place of Presentation
  京王プラザ(東京)
- Year and Date
  2010-04-27
- Data Source
  KAKENHI-PROJECT-22500389
[Presentation] 遺伝性腎癌におけErc/Mesothelin遺伝子の機能解析2007
- Author(s)
  小橋丹青(張丹青), ら
- Organizer
  第30回日本分子生物学会年会、第80回日本生化学会大会合同大会
- Place of Presentation
  パシフィコ横浜横浜
- Year and Date
  2007-12-14
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18500330
[Presentation] 遺伝性腎癌におけるErc/Mesothelin遺伝子の機能解析2007
- Author(s)
  小橋(張) 丹青, ら
- Organizer
  第30回日本分子生物学会年会・80回日本学会大会合同大会
- Place of Presentation
  パシフィコ横浜横浜
- Year and Date
  2007-12-14
- Data Source
  KAKENHI-PROJECT-18500330
[Presentation] The role of Erc/Mesothelin gene on renal carcinogenesis in Tsc2 knockout mice2007
- Author(s)
  Zhang, D, et. al.
- Organizer
  80th Biochemistry and 30th Molecular Biology 2007 Japan
- Place of Presentation
  Pacifico Yokohama, Yokohama Japan
- Year and Date
  2007-12-14
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18500330

1. HIROSE Sachiko (00127127)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
2. KOBAYASHI Toshiyuki (40260070)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
3. HINO Okio (90127910)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
4. MATSUOKA Shouji (20286743)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 濱野慶朋 (10281354)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 白井俊一 (30115860)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 姜奕 (50276466)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

ZHANG Danqing 張 丹青

張 丹青 チョウ タンセイ

Research Projects

Research Products

Co-Researchers

The mechanism of loss of Erc gene ameliorates renal carcinogenesis and modulates integrin related pathwayPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The functional analysis of Erc gene encoding GPI anchor proteinPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The role of MHC sub-region in autoimmune susceptibility and suppressor CD8 T cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Mechanism for MHC class II E region-linked autoimmune suppression.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

新しいB細胞性慢性リンパ性白血病の責任遺伝子の同定

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Studies on mechanism of pathogenic autoantibody production using CAT-transgenic autoimmune-prone mice

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Tuberin activates and controls the distribution of Rac1 viaassociation with p62 and ubiquitinthrough the mTORC1 signaling pathway2013

Author(s)

Journal Title

Data Source

[Journal Article] Deficiency of the Erc/mesothelin gene ameliorates renal cazcinogenesis in Tsc2 knockout mice.2011

Author(s)

Journal Title

Data Source

[Journal Article] Deficiency of the Erc/mesothelin gene ameliorates renal carcinogenesis in Tsc2 knockout mice2011

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Serine 62 is a phosphorylation site in folliculin, the Birt-Hogg-Dubegene product2010

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Genetic dissection of vasculitis, myeloperoxidase-specific antineurtophil cytoplasmic autoantibody production, and related traits in spontaneous crescentic glomerulonephritis-forming/kinjoh mice.2006

Author(s)

Journal Title

Data Source

[Journal Article] コラーゲン誘導関節炎の発症に及ぼす抗体遺伝子の影響2004

Author(s)

Journal Title

NAID

Description

Data Source

[Journal Article] The contribution of Igh allotype to the development of collagen-induced arthritis. (Article in Japanese)2004

Author(s)

Journal Title

Description

Data Source

[Journal Article] コラーゲン誘導関節炎の発症に及ぼす抗体遺伝子の影響2004

Author(s)

Journal Title

NAID

Data Source

ZHANG Danqing 張丹青

張丹青チョウタンセイ