YOSHITOME Kei 吉留敬

Researcher Number	40304307
Other IDs
External Links
Affiliation *help	2014 – 2018 : 川崎医科大学, 医学部, 講師 2007 : Okayama University, 大学院・医歯薬学総合研究科, 助教 2006 : 岡山大学, 大学院・医歯薬学総合研究科, 助手 2005 – 2006 : 岡山大学, 大学院医歯薬学総合研究科, 助手 2001 – 2004 : 岡山大学, 大学院・医歯学総合研究科, 助手 2000 : 岡山大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Legal medicine / Legal medicine Except Principal Investigator Legal medicine / Legal medicine / Hygiene and public health
Keywords	Principal Investigator forensic toxicology / flecainide / 死後変化 / フレカイニド / postmortem changes of drugs / 分布 / 中毒 / postmortem redistribution / Solid phase micro extraction / perfusion … More Except Principal Investigator 免疫 / 産業衛生 / DNA多型 / ナノ毒性 / Sex chromosome / エンドソーム / 単球 / HLA-DRB1型 / メタンフェタミン / Capillary electrophoresis / 一塩基多型(SNP) / Postmortem interval / 塩基多型(SNP) / Single nucleotide polymorphisms (SNPs) / ミオグロビン / 多座位同時検出法 / 母体血 / 高速分析法 / 石綿 / 予防 / ガスクロマトグラフィー / 空胞 / 社会医学 / Multiplex typing method / 悪性中皮腫 / ABO式血液型 / ABO blood groups / HLA DRB1 types / 性染色体 / 動物実験モデル / チタン / High throughput / 出生前診断 / 胎児有核赤血球 / 胃内排泄 / 法中毒学 / 親子鑑定 / DND polymorphisms / 薬物分析 / 静脈内投与 / ガスクロマトグラフ-質量分析法 / 空砲 / 静脈内投与薬物 / マイクロマニピュレーション / Forensic diagnosis / Myogloin / 死後経過時間 / ヒト / リンパ球 / 塩基性薬物 / 一塩基多型(SNPs) / キャピラリー電気泳動 / 法医診断 / 尿中濃度 / 塩基性代謝物 Less

包括的免疫機能解析による悪性中皮腫予防診断スコアの構築Ongoing
- Principal Investigator
  
  西村泰光
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hygiene and public health
- Research Institution
  Kawasaki Medical School
Immunotoxicity of titanate nanosheets
- Principal Investigator
  
  西村泰光
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Hygiene and public health
- Research Institution
  Kawasaki Medical School
Forensic Toxicological Study on Excretion of Intravenously Administered Drugs into the Stomach
- Principal Investigator
  
  MORIYA Fumio
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Legal medicine
- Research Institution
  Kawasaki University of Medical Welfare
薬物の死後再分布に関する研究 -死後の血液のpHの低下と薬物のpKaの視点から-Principal Investigator
- Principal Investigator
  
  吉留敬
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Legal medicine
- Research Institution
  Okayama University
Study on the practical usefulness of myoglobin from the aspects of forensic diagnosis
- Principal Investigator
  
  MIYAISHI Satoru
- Project Period (FY)
  2003 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Legal medicine
- Research Institution
  Okayama University
長期シンナー吸入時の有機溶剤耐性形成に関する研究-GABAレセプターとの関連性について-Principal Investigator
- Principal Investigator
  
  吉留敬
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Legal medicine
- Research Institution
  Okayama University
Development of a high throughput SNP typing method using capillary electrophoresis
- Principal Investigator
  
  ISHIZU Hideo
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Legal medicine
- Research Institution
  OKAYAMA UNIVERSITY
不整脈治療薬の心臓血中濃度が死後上昇する機構の解明に関する研究Principal Investigator
- Principal Investigator
  
  吉留敬
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Legal medicine
- Research Institution
  Okayama University
母体末梢血からの胎児DNA多型分析法の開発
- Principal Investigator
  
  ISHIZU Hideo
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Legal medicine
- Research Institution
  Okayama University

All 2018 2017 2016 2015 2014 2007 Other

All Journal Article Presentation Book

[Book] Cytotoxicity2018
- Author(s)
  Yasumitsu Nishimura, Daisuke Yoshioka, Naoko Kumagai-Takei, Suni Lee, Hidenori Matsuzaki, Kei Yoshitome, Takemi Otsuki
- Publisher
  IntechOpen
- ISBN
  9789535158691
- Data Source
  KAKENHI-PROJECT-15K15245
[Book] Advances in Medicine and Biology. Volume 1232017
- Author(s)
  Kumagai-Takei N, Nishimura Y, Matsuzaki H, Lee S, Yoshitome K, Yamamoto S, Ikeda M, Hatayama T, Maeda M, Otsuki T
- Total Pages
  257
- Publisher
  NOVA publisher,
- ISBN
  9781536121780
- Data Source
  KAKENHI-PROJECT-16H05264
[Journal Article] Inflammatory Alteration of Human T Cells Exposed Continuously to Asbestos2018
- Author(s)
  Kumagai-Takei N, Yamamoto S, Lee S, Maeda M, Matsuzaki H, Sada N, Yu M, Yoshitome K, Nishimura Y, Otsuki T.
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume : 19 Pages : 504-504
- DOI
  10.3390/ijms19020504
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09114, KAKENHI-PROJECT-16H05264
[Journal Article] Titanate nanosheets cause caspase-dependent apoptosis of human immune cells with giant vacuole formation through endosomal defect in monocytes2017
- Author(s)
  Nishimura Yasumitsu、Yoshioka Daisuke、Kumagai-Takei Naoko、Lee Suni、Matsuzaki Hidenori、Yoshitome Kei、Otsuki Takemi
- Journal Title
  
  Toxicology Letters
  
  Volume : 280
- DOI
  10.1016/j.toxlet.2017.07.512
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K15245
[Journal Article] Search for biomarkers of asbestos exposure and asbestos-induced cancers in investigations of the immunological effects of asbestos.2017
- Author(s)
  Matsuzaki Hidenori、Kumagai-Takei Naoko、Lee Suni、Maeda Megumi、Sada Nagisa、Hatayama Tamayo、Yamamoto Shoko、Ikeda Miho、Yoshitome Kei、Min Yu、Nishimura Yasumitsu、Otsuki Takemi
- Journal Title
  
  Environ. Health Prev. Med.
  
  Volume : 22
- DOI
  10.1186/s12199-017-0661-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05264, KAKENHI-PROJECT-15K08788
[Journal Article] Accelerated cell cycle progression of human regulatory T cell-like cell line caused by continuous exposure to asbestos fibers2017
- Author(s)
  Lee Suni、Matsuzaki Hidenori、Maeda Megumi、Yamamoto Shoko、Kumagai-Takei Naoko、Hatayama Tamayo、Ikeda Miho、Yoshitome Kei、Nishimura Yasumitsu、Otsuki Takemi
- Journal Title
  
  International Journal of Oncology
  
  Volume : 50 Issue : 1 Pages : 66-74
- Publisher
  Spandidos
- DOI
  10.3892/ijo.2016.3776
- PMID
  info:pmid/27878235
- ISSN
  1019-6439
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05264
[Journal Article] Induction of IL-17 production from human peripheral blood CD4+ cells by asbestos exposure2017
- Author(s)
  Maeda Megumi、Chen Ying、Lee Suni、Kumagai-Takei Naoko、Yoshitome Kei、Matsuzaki Hidenori、Yamamoto Shoko、Hatayama Tamayo、Ikeda Miho、Nishimura Yasumitsu、Otsuki Takemi
- Journal Title
  
  International Journal of Oncology
  
  Volume : 50 Issue : 6 Pages : 2024-2032
- Publisher
  Spandidos
- DOI
  10.3892/ijo.2017.3991
- PMID
  info:pmid/28498408
- ISSN
  1019-6439
- Year and Date
  2017-05-09
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05264, KAKENHI-PROJECT-15K08788
[Journal Article] Environmental factors and human health: fibrous and particulate substance-induced immunological disorders and construction of a health-promoting living environment.2016
- Author(s)
  Otsuki, T. Matsuzaki, H. Lee, S. Kumagai-Takei, N. Yamamoto, S. Hatayama, T. Yoshitome, K. Nishimura, Y.
- Journal Title
  
  Environ. Heallth Prev. Med.
  
  Volume : 21 Pages : 71-81
- DOI
  10.1007/s12199-015-0499-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05264, KAKENHI-PROJECT-15K08788, KAKENHI-PROJECT-15K15245
[Journal Article] The suppressed induction of human mature cytotoxic T lymphocytes caused by asbestos is not due to Interleukin-2 insufficiency.2016
- Author(s)
  Kumagai-Takei, N. Nishimura, Y. Matsuzaki, H. Lee, S. Yoshitome, K. Hayashi, H. Otsuki, T.
- Journal Title
  
  J. Immunol. Res.
  
  Volume : 2016 Pages : 1-10
- DOI
  10.1155/2016/7484872
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05264, KAKENHI-PROJECT-15K08788, KAKENHI-PROJECT-16K09114
[Journal Article] Gastric excretion of intravenously administered drugs in critical care patients2016
- Author(s)
  Fumio Moriya, Kei Yoshitome, Satoru Miyaishi
- Journal Title
  
  Legal Medicine
  
  Volume : 23巻 Pages : 77-78
- DOI
  10.1016/j.legalmed.2016.10.002
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460893
[Journal Article] Postmorem increase of flecainide level in cardiac blood
- Author(s)
  Kei yoshitome, et. al.
- Journal Title
  
  journal of analytycal toxycology (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18689017
[Presentation] Difference in Immunological Characteristics between Patients with Malignant Mesothelioma and Diffuse Pleural Thickening2018
- Author(s)
  Yasumitsu Nishimura, Suni Lee, Naoko Kumagai-Takei, Hidenori Matsuzaki, Kei Yoshitome, Takemi Otsuki
- Organizer
  The 57th Annual Meeting of the Society of Toxicology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05264
[Presentation] The Functional Analysis of Human CD8+ T Cell Line with Long-Term Exposure to Chrysotile Asbestos Fibers2018
- Author(s)
  Kumagai-Takei N. Nishimura Y, Matsuzaki H, Lee S, Yoshitome K, Otsuki T
- Organizer
  The 57th Annual Meeting of the Society of Toxicology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05264
[Presentation] Continuous and low-dose exposure to asbestos on human T cells causes reduction of anti-tumor immunity2017
- Author(s)
  Otsuki T, Maeda M, Lee S, Matsuzaki H, Kumagai-Takei N, Yoshitome K, Sada N, Nishimura Y
- Organizer
  International Conference on Environmental Health and Environmental-related Cancer Prevention 2017: Assessing low-doses and cumulative effects of exposure to chemical mixtures
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05264
[Presentation] 免疫細胞由来因子により引き起こされるヒト中皮細胞増殖脳の石綿耐性2017
- Author(s)
  西村泰光，李順姫，武井直子，松﨑秀紀，吉留敬，大槻剛巳
- Organizer
  第87回日本衛生学会学術総会
- Place of Presentation
  フェニックス・シーガイア・リゾート, 宮崎県, 宮崎市
- Year and Date
  2017-03-27
- Data Source
  KAKENHI-PROJECT-16H05264
[Presentation] Titanate nanosheets cause caspase-dependent apoptosis of human immune cells with giant vacuole formation through endosomal defect in monochytes2017
- Author(s)
  Nishimura Y, Yoshioka D, Kumagai-Takei N, Lee S, Matsuzaki H, Yoshitome K, Otsuki T
- Organizer
  The 53rd Congress of the European Societies of Toxicology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15245
[Presentation] Apoptosis of monocytes with giant vacuoles related to disruption in endosomal pathway caused by titanate nanosheets2017
- Author(s)
  Nishimura Y, Kumagai-Takei N, Lee S, Matsuzaki H, Yoshitome K, Otsuki T
- Organizer
  The British Society for Immunology Congress 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15245
[Presentation] チタン酸ナノシート曝露によるヒトPBMCのアポトーシスと単球における巨大空胞形成2017
- Author(s)
  西村泰光，吉岡大輔，李順姫，武井直子，松崎秀紀，吉留敬，大槻剛巳
- Organizer
  第90回日本産業衛生学会
- Data Source
  KAKENHI-PROJECT-15K15245
[Presentation] The immunological screening devices for human malignant mesothelioma and asbestos exposure2017
- Author(s)
  Nishimura Y, Lee S, Kumagai-Takei N, Mastuzaki H, Yoshitome K, Otsuki T
- Organizer
  The 27th Japan Korea China Conference on Occupational Health
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05264
[Presentation] 空砲形成を伴う細胞死を惹起するチタン酸ナノシートの単球への取り込みと細胞内動態2016
- Author(s)
  西村泰光, 吉岡大輔, 李順姫, 武井直子, 松崎秀紀, 吉留敬, 大槻剛巳
- Organizer
  第86回日本衛生学会学術総会
- Place of Presentation
  旭川市民文化会館, 北海道, 旭川市
- Year and Date
  2016-05-13
- Data Source
  KAKENHI-PROJECT-15K15245
[Presentation] 血中メタンフェタミンの胃内移行メカニズムの解明に向けた動物実験モデルの構築2016
- Author(s)
  吉留敬、守屋文夫、宮石智
- Organizer
  第100次日本法医学会学術全国集会
- Place of Presentation
  きゅりあん（東京都品川区）
- Data Source
  KAKENHI-PROJECT-26460893
[Presentation] 血中メタンフェタミンの胃内移行メカニズムの解明2016
- Author(s)
  吉留敬、守屋文夫、宮石智
- Organizer
  第33回日本法医学会学術中四国地方集会
- Place of Presentation
  広島大学霞キャンパス広仁会館（広島市南区）
- Data Source
  KAKENHI-PROJECT-26460893
[Presentation] Vacuole Formation And Caspase-dependent Apoptosis In Human Monocytes Caused By Exposure To Titanate Nanosheet2016
- Author(s)
  Nishimura Y, Yoshioka D, Lee S, Kumagai-Takei N, Matsuzaki H, Yoshitome K, Otsuki T
- Organizer
  The 55th Annual Meeting. Society of Toxicology
- Place of Presentation
  New Orleans Ernest N． Morial Convention Center (New Orleans, Louisiana)
- Year and Date
  2016-03-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15245
[Presentation] 悪性中皮腫スクリーニングデバイスとしての免疫学的スコア式の開発2016
- Author(s)
  西村泰光，李順姫，武井直子，吉留敬，岸本卓巳，福岡和也，田端千春，中野孝司，大槻剛巳
- Organizer
  第89回日本産業衛生学会
- Place of Presentation
  福島県文化センター, 福島県, 福島市
- Year and Date
  2016-05-26
- Data Source
  KAKENHI-PROJECT-16H05264
[Presentation] アスベスト曝露と悪性中皮腫に関わる免疫学的特徴の解析とスクリーニングデバイスの開発2016
- Author(s)
  西村泰光，李順姫，武井直子，松﨑秀紀，吉留敬，大槻剛巳
- Organizer
  第23回日本免疫毒性学会学術年会
- Place of Presentation
  北九州国際会議場, 福岡県, 北九州市
- Year and Date
  2016-09-06
- Invited
- Data Source
  KAKENHI-PROJECT-16H05264
[Presentation] チタン酸ナノシート曝露による単球の空胞形成と細胞死2015
- Author(s)
  西村泰光, 吉岡大輔, 李順姫, 武井直子, 松崎秀紀, 吉留敬, 大槻剛巳
- Organizer
  第22回日本免疫毒性学会学術年会
- Place of Presentation
  京都大学百周年時計台記念館国際交流ホール（京都）
- Year and Date
  2015-09-10
- Data Source
  KAKENHI-PROJECT-15K15245
[Presentation] 血中塩基性薬物の胃内移行程度に関する検討2015
- Author(s)
  守屋文夫、吉留敬、宮石智
- Organizer
  第27回日本中毒学会中国四国地方会学術集会
- Place of Presentation
  山口大学医学部霜仁会館（山口県宇部市）
- Year and Date
  2015-11-28
- Data Source
  KAKENHI-PROJECT-26460893
[Presentation] 血中塩基性薬物の胃内出現態様2015
- Author(s)
  守屋文夫、吉留敬、宮石智
- Organizer
  第99次日本法医学会学術全国集会
- Place of Presentation
  高知市文化プラザかるぽーと（高知県高知市）
- Year and Date
  2015-06-11
- Data Source
  KAKENHI-PROJECT-26460893
[Presentation] 静脈内投与されたメタンフェタミンの胃内濃度に関する検討2015
- Author(s)
  吉留敬、守屋文夫、宮石智
- Organizer
  第32回日本法医学会学術中四国地方集会
- Place of Presentation
  岡山大学医学部 Junko Fukutake Hall（岡山県岡山市）
- Year and Date
  2015-10-31
- Data Source
  KAKENHI-PROJECT-26460893
[Presentation] 薬物消失期における胃内容と血液のカルバマゼピン濃度の関係－基礎実験による検証2015
- Author(s)
  吉留敬、守屋文夫
- Organizer
  第37回日本中毒学会総会・学術集会
- Place of Presentation
  和歌山県民文化会館（和歌山県和歌山市）
- Year and Date
  2015-07-18
- Data Source
  KAKENHI-PROJECT-26460893
[Presentation] Characteristic of the manner of death in methamphetamine abusers who underwent forensic autopsy2014
- Author(s)
  Fumio Moriya, Kei Yoshitome, Satoru Miyaishi
- Organizer
  9th International Symposium on Advances in Legal Medicine
- Place of Presentation
  福岡国際会議場（福岡県福岡市）
- Year and Date
  2014-06-17
- Data Source
  KAKENHI-PROJECT-26460893
[Presentation] 静脈内投与された塩基性薬物の胃内容濃度と尿中濃度：剖検例での検討2014
- Author(s)
  守屋文夫、吉留敬、宮石智
- Organizer
  第36回日本中毒学会総会・学術集会
- Place of Presentation
  帝京大学板橋キャンパス（東京都板橋区）
- Year and Date
  2014-07-25
- Data Source
  KAKENHI-PROJECT-26460893
[Presentation] Mechanism of postmortem increase of basic drug concentration in cardiac blood2007
- Author(s)
  Kei yoshitome, et. al.
- Organizer
  86. Jahrestagung der Deutschen Gesellschaft fur Rechtsmedizin
- Place of Presentation
  Mainz, Germany
- Year and Date
  2007-09-28
- Data Source
  KAKENHI-PROJECT-18689017
[Presentation] 抗不整脈薬フレカイニドの心臓血中濃度の死後上昇.2007
- Author(s)
  吉留敬, 他
- Organizer
  第91次日本法医学会総会
- Place of Presentation
  秋田
- Year and Date
  2007-05-18
- Data Source
  KAKENHI-PROJECT-18689017

1. MIYAISHI Satoru (90239343)

# of Collaborated Projects : 4results

# of Collaborated Products : 8results
2. ISHIZU Hideo (70033157)

# of Collaborated Projects : 3results

# of Collaborated Products : 0results
3. YAMAMOTO Yuji (30136379)

# of Collaborated Projects : 3results

# of Collaborated Products : 0results
4. INAGAKI Sachiyo (00325086)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
5. 西村泰光 (90360271)

# of Collaborated Projects : 2results

# of Collaborated Products : 22results
6. 大槻剛巳 (40160551)

# of Collaborated Projects : 2results

# of Collaborated Products : 22results
7. 武井直子 (00509276)

# of Collaborated Projects : 2results

# of Collaborated Products : 22results
8. 松崎秀紀 (80335463)

# of Collaborated Projects : 2results

# of Collaborated Products : 17results
9. 李順姫 (70414026)

# of Collaborated Projects : 2results

# of Collaborated Products : 22results
10. MORIYA Fumio (40182274)

# of Collaborated Projects : 1results

# of Collaborated Products : 9results
11. KITAO Takashi (60218047)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
12. TAKATA Tomoyo (70310894)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
13. 吉岡大輔 (40638318)

# of Collaborated Projects : 1results

# of Collaborated Products : 3results

YOSHITOME Kei 吉留 敬

Research Projects

Research Products

Co-Researchers

包括的免疫機能解析による悪性中皮腫予防診断スコアの構築Ongoing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Immunotoxicity of titanate nanosheets

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Forensic Toxicological Study on Excretion of Intravenously Administered Drugs into the Stomach

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

薬物の死後再分布に関する研究 -死後の血液のpHの低下と薬物のpKaの視点から-Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study on the practical usefulness of myoglobin from the aspects of forensic diagnosis

Principal Investigator

Project Period (FY)

Research Category

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長期シンナー吸入時の有機溶剤耐性形成に関する研究-GABAレセプターとの関連性について-Principal Investigator

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Development of a high throughput SNP typing method using capillary electrophoresis

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不整脈治療薬の心臓血中濃度が死後上昇する機構の解明に関する研究Principal Investigator

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母体末梢血からの胎児DNA多型分析法の開発

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[Book] Cytotoxicity2018

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[Book] Advances in Medicine and Biology. Volume 1232017

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[Journal Article] Inflammatory Alteration of Human T Cells Exposed Continuously to Asbestos2018

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[Journal Article] Titanate nanosheets cause caspase-dependent apoptosis of human immune cells with giant vacuole formation through endosomal defect in monocytes2017

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[Journal Article] Search for biomarkers of asbestos exposure and asbestos-induced cancers in investigations of the immunological effects of asbestos.2017

YOSHITOME Kei 吉留敬

[Presentation] チタン酸ナノシート曝露によるヒトPBMCのアポトーシスと単球における巨大空胞形成2017