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YOSHITOME Kei  吉留 敬

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Researcher Number 40304307
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Affiliation *help 2014 – 2018 : 川崎医科大学, 医学部, 講師
2007 : Okayama University, 大学院・医歯薬学総合研究科, 助教
2006 : 岡山大学, 大学院・医歯薬学総合研究科, 助手
2005 – 2006 : 岡山大学, 大学院医歯薬学総合研究科, 助手
2001 – 2004 : 岡山大学, 大学院・医歯学総合研究科, 助手
2000 : 岡山大学, 医学部, 助手
Review Section/Research Field
Principal Investigator
Legal medicine / Legal medicine
Except Principal Investigator
Legal medicine / Legal medicine / Hygiene and public health
Keywords
Principal Investigator
forensic toxicology / flecainide / 死後変化 / フレカイニド / postmortem changes of drugs / 分布 / 中毒 / postmortem redistribution / Solid phase micro extraction / perfusion … More / 死後拡散 / intergradation / Expose / postmortem increase / 酸性化 / acidification / Toluene / methamphetamine / Gas chromatography / 法中毒学 / Xylene / perfusion experiment / GC / acid dissociation constant / Toluen / 濃度変化 / 医療過誤 / SPME / 灌流 / t-butylbicyclophosphorothionate / pKa / distribution / therapeutic dose / GABA … More
Except Principal Investigator
免疫 / 産業衛生 / DNA多型 / ナノ毒性 / Sex chromosome / エンドソーム / 単球 / HLA-DRB1型 / メタンフェタミン / Capillary electrophoresis / 一塩基多型(SNP) / Postmortem interval / 塩基多型(SNP) / Single nucleotide polymorphisms (SNPs) / ミオグロビン / 多座位同時検出法 / 母体血 / 高速分析法 / 石綿 / 予防 / ガスクロマトグラフィー / 空胞 / 社会医学 / Multiplex typing method / 悪性中皮腫 / ABO式血液型 / ABO blood groups / HLA DRB1 types / 性染色体 / 動物実験モデル / チタン / High throughput / 出生前診断 / 胎児有核赤血球 / 胃内排泄 / 法中毒学 / 親子鑑定 / DND polymorphisms / 薬物分析 / 静脈内投与 / ガスクロマトグラフ-質量分析法 / 空砲 / 静脈内投与薬物 / マイクロマニピュレーション / Forensic diagnosis / Myogloin / 死後経過時間 / ヒト / リンパ球 / 塩基性薬物 / 一塩基多型(SNPs) / キャピラリー電気泳動 / 法医診断 / 尿中濃度 / 塩基性代謝物 Less
  • Research Projects

    (9results)
  • Research Products

    (34results)
  • Co-Researchers

    (13People)
  •  包括的免疫機能解析による悪性中皮腫予防診断スコアの構築Ongoing

    • Principal Investigator
      西村 泰光
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Hygiene and public health
    • Research Institution
      Kawasaki Medical School
  •  Immunotoxicity of titanate nanosheets

    • Principal Investigator
      西村 泰光
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Hygiene and public health
    • Research Institution
      Kawasaki Medical School
  •  Forensic Toxicological Study on Excretion of Intravenously Administered Drugs into the Stomach

    • Principal Investigator
      MORIYA Fumio
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Legal medicine
    • Research Institution
      Kawasaki University of Medical Welfare
  •  薬物の死後再分布に関する研究 -死後の血液のpHの低下と薬物のpKaの視点から-Principal Investigator

    • Principal Investigator
      吉留 敬
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Young Scientists (A)
    • Research Field
      Legal medicine
    • Research Institution
      Okayama University
  •  Study on the practical usefulness of myoglobin from the aspects of forensic diagnosis

    • Principal Investigator
      MIYAISHI Satoru
    • Project Period (FY)
      2003 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Legal medicine
    • Research Institution
      Okayama University
  •  長期シンナー吸入時の有機溶剤耐性形成に関する研究-GABAレセプターとの関連性について-Principal Investigator

    • Principal Investigator
      吉留 敬
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Legal medicine
    • Research Institution
      Okayama University
  •  Development of a high throughput SNP typing method using capillary electrophoresis

    • Principal Investigator
      ISHIZU Hideo
    • Project Period (FY)
      2001 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Legal medicine
    • Research Institution
      OKAYAMA UNIVERSITY
  •  不整脈治療薬の心臓血中濃度が死後上昇する機構の解明に関する研究Principal Investigator

    • Principal Investigator
      吉留 敬
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Legal medicine
    • Research Institution
      Okayama University
  •  母体末梢血からの胎児DNA多型分析法の開発

    • Principal Investigator
      ISHIZU Hideo
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Legal medicine
    • Research Institution
      Okayama University

All 2018 2017 2016 2015 2014 2007 Other

All Journal Article Presentation Book

  • [Book] Cytotoxicity2018

    • Author(s)
      Yasumitsu Nishimura, Daisuke Yoshioka, Naoko Kumagai-Takei, Suni Lee, Hidenori Matsuzaki, Kei Yoshitome, Takemi Otsuki
    • Publisher
      IntechOpen
    • ISBN
      9789535158691
    • Data Source
      KAKENHI-PROJECT-15K15245
  • [Book] Advances in Medicine and Biology. Volume 1232017

    • Author(s)
      Kumagai-Takei N, Nishimura Y, Matsuzaki H, Lee S, Yoshitome K, Yamamoto S, Ikeda M, Hatayama T, Maeda M, Otsuki T
    • Total Pages
      257
    • Publisher
      NOVA publisher,
    • ISBN
      9781536121780
    • Data Source
      KAKENHI-PROJECT-16H05264
  • [Journal Article] Inflammatory Alteration of Human T Cells Exposed Continuously to Asbestos2018

    • Author(s)
      Kumagai-Takei N, Yamamoto S, Lee S, Maeda M, Matsuzaki H, Sada N, Yu M, Yoshitome K, Nishimura Y, Otsuki T.
    • Journal Title

      International Journal of Molecular Sciences

      Volume : 19 Pages : 504-504

    • DOI
      10.3390/ijms19020504
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K09114, KAKENHI-PROJECT-16H05264
  • [Journal Article] Titanate nanosheets cause caspase-dependent apoptosis of human immune cells with giant vacuole formation through endosomal defect in monocytes2017

    • Author(s)
      Nishimura Yasumitsu、Yoshioka Daisuke、Kumagai-Takei Naoko、Lee Suni、Matsuzaki Hidenori、Yoshitome Kei、Otsuki Takemi
    • Journal Title

      Toxicology Letters

      Volume : 280

    • DOI
      10.1016/j.toxlet.2017.07.512
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K15245
  • [Journal Article] Search for biomarkers of asbestos exposure and asbestos-induced cancers in investigations of the immunological effects of asbestos.2017

    • Author(s)
      Matsuzaki Hidenori、Kumagai-Takei Naoko、Lee Suni、Maeda Megumi、Sada Nagisa、Hatayama Tamayo、Yamamoto Shoko、Ikeda Miho、Yoshitome Kei、Min Yu、Nishimura Yasumitsu、Otsuki Takemi
    • Journal Title

      Environ. Health Prev. Med.

      Volume : 22

    • DOI
      10.1186/s12199-017-0661-4
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16H05264, KAKENHI-PROJECT-15K08788
  • [Journal Article] Accelerated cell cycle progression of human regulatory T cell-like cell line caused by continuous exposure to asbestos fibers2017

    • Author(s)
      Lee Suni、Matsuzaki Hidenori、Maeda Megumi、Yamamoto Shoko、Kumagai-Takei Naoko、Hatayama Tamayo、Ikeda Miho、Yoshitome Kei、Nishimura Yasumitsu、Otsuki Takemi
    • Journal Title

      International Journal of Oncology

      Volume : 50 Issue : 1 Pages : 66-74

    • Publisher
      Spandidos
    • DOI
      10.3892/ijo.2016.3776
    • PMID
      info:pmid/27878235
    • ISSN
      1019-6439
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16H05264
  • [Journal Article] Induction of IL-17 production from human peripheral blood CD4+ cells by asbestos exposure2017

    • Author(s)
      Maeda Megumi、Chen Ying、Lee Suni、Kumagai-Takei Naoko、Yoshitome Kei、Matsuzaki Hidenori、Yamamoto Shoko、Hatayama Tamayo、Ikeda Miho、Nishimura Yasumitsu、Otsuki Takemi
    • Journal Title

      International Journal of Oncology

      Volume : 50 Issue : 6 Pages : 2024-2032

    • Publisher
      Spandidos
    • DOI
      10.3892/ijo.2017.3991
    • PMID
      info:pmid/28498408
    • ISSN
      1019-6439
    • Year and Date
      2017-05-09
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16H05264, KAKENHI-PROJECT-15K08788
  • [Journal Article] Environmental factors and human health: fibrous and particulate substance-induced immunological disorders and construction of a health-promoting living environment.2016

    • Author(s)
      Otsuki, T. Matsuzaki, H. Lee, S. Kumagai-Takei, N. Yamamoto, S. Hatayama, T. Yoshitome, K. Nishimura, Y.
    • Journal Title

      Environ. Heallth Prev. Med.

      Volume : 21 Pages : 71-81

    • DOI
      10.1007/s12199-015-0499-6
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16H05264, KAKENHI-PROJECT-15K08788, KAKENHI-PROJECT-15K15245
  • [Journal Article] The suppressed induction of human mature cytotoxic T lymphocytes caused by asbestos is not due to Interleukin-2 insufficiency.2016

    • Author(s)
      Kumagai-Takei, N. Nishimura, Y. Matsuzaki, H. Lee, S. Yoshitome, K. Hayashi, H. Otsuki, T.
    • Journal Title

      J. Immunol. Res.

      Volume : 2016 Pages : 1-10

    • DOI
      10.1155/2016/7484872
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16H05264, KAKENHI-PROJECT-15K08788, KAKENHI-PROJECT-16K09114
  • [Journal Article] Gastric excretion of intravenously administered drugs in critical care patients2016

    • Author(s)
      Fumio Moriya, Kei Yoshitome, Satoru Miyaishi
    • Journal Title

      Legal Medicine

      Volume : 23巻 Pages : 77-78

    • DOI
      10.1016/j.legalmed.2016.10.002
    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26460893
  • [Journal Article] Postmorem increase of flecainide level in cardiac blood

    • Author(s)
      Kei yoshitome, et. al.
    • Journal Title

      journal of analytycal toxycology (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18689017
  • [Presentation] Difference in Immunological Characteristics between Patients with Malignant Mesothelioma and Diffuse Pleural Thickening2018

    • Author(s)
      Yasumitsu Nishimura, Suni Lee, Naoko Kumagai-Takei, Hidenori Matsuzaki, Kei Yoshitome, Takemi Otsuki
    • Organizer
      The 57th Annual Meeting of the Society of Toxicology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05264
  • [Presentation] The Functional Analysis of Human CD8+ T Cell Line with Long-Term Exposure to Chrysotile Asbestos Fibers2018

    • Author(s)
      Kumagai-Takei N. Nishimura Y, Matsuzaki H, Lee S, Yoshitome K, Otsuki T
    • Organizer
      The 57th Annual Meeting of the Society of Toxicology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05264
  • [Presentation] Continuous and low-dose exposure to asbestos on human T cells causes reduction of anti-tumor immunity2017

    • Author(s)
      Otsuki T, Maeda M, Lee S, Matsuzaki H, Kumagai-Takei N, Yoshitome K, Sada N, Nishimura Y
    • Organizer
      International Conference on Environmental Health and Environmental-related Cancer Prevention 2017: Assessing low-doses and cumulative effects of exposure to chemical mixtures
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05264
  • [Presentation] 免疫細胞由来因子により引き起こされるヒト中皮細胞増殖脳の石綿耐性2017

    • Author(s)
      西村泰光,李順姫,武井直子,松﨑秀紀,吉留敬,大槻剛巳
    • Organizer
      第87回日本衛生学会学術総会
    • Place of Presentation
      フェニックス・シーガイア・リゾート, 宮崎県, 宮崎市
    • Year and Date
      2017-03-27
    • Data Source
      KAKENHI-PROJECT-16H05264
  • [Presentation] Titanate nanosheets cause caspase-dependent apoptosis of human immune cells with giant vacuole formation through endosomal defect in monochytes2017

    • Author(s)
      Nishimura Y, Yoshioka D, Kumagai-Takei N, Lee S, Matsuzaki H, Yoshitome K, Otsuki T
    • Organizer
      The 53rd Congress of the European Societies of Toxicology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K15245
  • [Presentation] Apoptosis of monocytes with giant vacuoles related to disruption in endosomal pathway caused by titanate nanosheets2017

    • Author(s)
      Nishimura Y, Kumagai-Takei N, Lee S, Matsuzaki H, Yoshitome K, Otsuki T
    • Organizer
      The British Society for Immunology Congress 2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K15245
  • [Presentation] チタン酸ナノシート曝露によるヒトPBMCのア ポトーシスと単球における巨大空胞形成2017

    • Author(s)
      西村泰光,吉岡大輔,李順姫,武井直子,松崎秀紀,吉留敬,大槻剛巳
    • Organizer
      第90回日本産業衛生学会
    • Data Source
      KAKENHI-PROJECT-15K15245
  • [Presentation] The immunological screening devices for human malignant mesothelioma and asbestos exposure2017

    • Author(s)
      Nishimura Y, Lee S, Kumagai-Takei N, Mastuzaki H, Yoshitome K, Otsuki T
    • Organizer
      The 27th Japan Korea China Conference on Occupational Health
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05264
  • [Presentation] 空砲形成を伴う細胞死を惹起するチタン酸ナノシートの単球への取り込みと細胞内動態2016

    • Author(s)
      西村泰光, 吉岡大輔, 李順姫, 武井直子, 松崎秀紀, 吉留敬, 大槻剛巳
    • Organizer
      第86回日本衛生学会学術総会
    • Place of Presentation
      旭川市民文化会館, 北海道, 旭川市
    • Year and Date
      2016-05-13
    • Data Source
      KAKENHI-PROJECT-15K15245
  • [Presentation] 血中メタンフェタミンの胃内移行メカニズムの解明に向けた動物実験モデルの構築2016

    • Author(s)
      吉留敬、守屋文夫、宮石智
    • Organizer
      第100次日本法医学会学術全国集会
    • Place of Presentation
      きゅりあん(東京都品川区)
    • Data Source
      KAKENHI-PROJECT-26460893
  • [Presentation] 血中メタンフェタミンの胃内移行メカニズムの解明2016

    • Author(s)
      吉留敬、守屋文夫、宮石智
    • Organizer
      第33回日本法医学会学術中四国地方集会
    • Place of Presentation
      広島大学霞キャンパス広仁会館(広島市南区)
    • Data Source
      KAKENHI-PROJECT-26460893
  • [Presentation] Vacuole Formation And Caspase-dependent Apoptosis In Human Monocytes Caused By Exposure To Titanate Nanosheet2016

    • Author(s)
      Nishimura Y, Yoshioka D, Lee S, Kumagai-Takei N, Matsuzaki H, Yoshitome K, Otsuki T
    • Organizer
      The 55th Annual Meeting. Society of Toxicology
    • Place of Presentation
      New Orleans Ernest N. Morial Convention Center (New Orleans, Louisiana)
    • Year and Date
      2016-03-16
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K15245
  • [Presentation] 悪性中皮腫スクリーニングデバイスとしての免疫学的スコア式の開発2016

    • Author(s)
      西村泰光,李順姫,武井直子,吉留敬,岸本卓巳,福岡和也,田端千春,中野孝司,大槻剛巳
    • Organizer
      第89回日本産業衛生学会
    • Place of Presentation
      福島県文化センター, 福島県, 福島市
    • Year and Date
      2016-05-26
    • Data Source
      KAKENHI-PROJECT-16H05264
  • [Presentation] アスベスト曝露と悪性中皮腫に関わる免疫学的特徴の解析とスクリーニングデバイスの開発2016

    • Author(s)
      西村泰光,李順姫,武井直子,松﨑秀紀,吉留敬,大槻剛巳
    • Organizer
      第23回日本免疫毒性学会学術年会
    • Place of Presentation
      北九州国際会議場, 福岡県, 北九州市
    • Year and Date
      2016-09-06
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H05264
  • [Presentation] チタン酸ナノシート曝露による単球の空胞形成と細胞死2015

    • Author(s)
      西村泰光, 吉岡大輔, 李順姫, 武井直子, 松崎秀紀, 吉留敬, 大槻剛巳
    • Organizer
      第22回日本免疫毒性学会学術年会
    • Place of Presentation
      京都大学百周年時計台記念館国際交流ホール(京都)
    • Year and Date
      2015-09-10
    • Data Source
      KAKENHI-PROJECT-15K15245
  • [Presentation] 血中塩基性薬物の胃内移行程度に関する検討2015

    • Author(s)
      守屋文夫、吉留敬、宮石智
    • Organizer
      第27回日本中毒学会中国四国地方会学術集会
    • Place of Presentation
      山口大学医学部霜仁会館(山口県宇部市)
    • Year and Date
      2015-11-28
    • Data Source
      KAKENHI-PROJECT-26460893
  • [Presentation] 血中塩基性薬物の胃内出現態様2015

    • Author(s)
      守屋文夫、吉留敬、宮石智
    • Organizer
      第99次日本法医学会学術全国集会
    • Place of Presentation
      高知市文化プラザかるぽーと(高知県高知市)
    • Year and Date
      2015-06-11
    • Data Source
      KAKENHI-PROJECT-26460893
  • [Presentation] 静脈内投与されたメタンフェタミンの胃内濃度に関する検討2015

    • Author(s)
      吉留敬、守屋文夫、宮石智
    • Organizer
      第32回日本法医学会学術中四国地方集会
    • Place of Presentation
      岡山大学医学部 Junko Fukutake Hall(岡山県岡山市)
    • Year and Date
      2015-10-31
    • Data Source
      KAKENHI-PROJECT-26460893
  • [Presentation] 薬物消失期における胃内容と血液のカルバマゼピン濃度の関係-基礎実験による検証2015

    • Author(s)
      吉留敬、守屋文夫
    • Organizer
      第37回日本中毒学会総会・学術集会
    • Place of Presentation
      和歌山県民文化会館(和歌山県和歌山市)
    • Year and Date
      2015-07-18
    • Data Source
      KAKENHI-PROJECT-26460893
  • [Presentation] Characteristic of the manner of death in methamphetamine abusers who underwent forensic autopsy2014

    • Author(s)
      Fumio Moriya, Kei Yoshitome, Satoru Miyaishi
    • Organizer
      9th International Symposium on Advances in Legal Medicine
    • Place of Presentation
      福岡国際会議場(福岡県福岡市)
    • Year and Date
      2014-06-17
    • Data Source
      KAKENHI-PROJECT-26460893
  • [Presentation] 静脈内投与された塩基性薬物の胃内容濃度と尿中濃度:剖検例での検討2014

    • Author(s)
      守屋文夫、吉留敬、宮石智
    • Organizer
      第36回日本中毒学会総会・学術集会
    • Place of Presentation
      帝京大学板橋キャンパス(東京都板橋区)
    • Year and Date
      2014-07-25
    • Data Source
      KAKENHI-PROJECT-26460893
  • [Presentation] Mechanism of postmortem increase of basic drug concentration in cardiac blood2007

    • Author(s)
      Kei yoshitome, et. al.
    • Organizer
      86. Jahrestagung der Deutschen Gesellschaft fur Rechtsmedizin
    • Place of Presentation
      Mainz, Germany
    • Year and Date
      2007-09-28
    • Data Source
      KAKENHI-PROJECT-18689017
  • [Presentation] 抗不整脈薬フレカイニドの心臓血中濃度の死後上昇.2007

    • Author(s)
      吉留敬, 他
    • Organizer
      第91次日本法医学会総会
    • Place of Presentation
      秋田
    • Year and Date
      2007-05-18
    • Data Source
      KAKENHI-PROJECT-18689017
  • 1.  MIYAISHI Satoru (90239343)
    # of Collaborated Projects : 4results
    # of Collaborated Products : 8results
  • 2.  ISHIZU Hideo (70033157)
    # of Collaborated Projects : 3results
    # of Collaborated Products : 0results
  • 3.  YAMAMOTO Yuji (30136379)
    # of Collaborated Projects : 3results
    # of Collaborated Products : 0results
  • 4.  INAGAKI Sachiyo (00325086)
    # of Collaborated Projects : 2results
    # of Collaborated Products : 0results
  • 5.  西村 泰光 (90360271)
    # of Collaborated Projects : 2results
    # of Collaborated Products : 22results
  • 6.  大槻 剛巳 (40160551)
    # of Collaborated Projects : 2results
    # of Collaborated Products : 22results
  • 7.  武井 直子 (00509276)
    # of Collaborated Projects : 2results
    # of Collaborated Products : 22results
  • 8.  松崎 秀紀 (80335463)
    # of Collaborated Projects : 2results
    # of Collaborated Products : 17results
  • 9.  李 順姫 (70414026)
    # of Collaborated Projects : 2results
    # of Collaborated Products : 22results
  • 10.  MORIYA Fumio (40182274)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 9results
  • 11.  KITAO Takashi (60218047)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 0results
  • 12.  TAKATA Tomoyo (70310894)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 0results
  • 13.  吉岡 大輔 (40638318)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 3results

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