Terajima Hiroaki 寺嶋宏明

… Alternative Names

TERAJIMA Hiroaki 寺嶋宏明

寺島宏明テラシマヒロアキ

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Researcher Number	40314215
External Links
Affiliation (Current)	2025: 公益財団法人田附興風会, 医学研究所北野病院腫瘍研究部, 研究主幹
Affiliation (based on the past Project Information) *help	2023: 公益財団法人田附興風会, 医学研究所腫瘍研究部, 研究主幹 2021: 公益財団法人田附興風会, 医学研究所腫瘍研究部, 研究主幹 2013 – 2020: 公益財団法人田附興風会, 医学研究所第1研究部, 研究主幹 2001 – 2003: Kyoto University, Medicine, Lecturer, 医学研究科, 講師 2000 – 2003: 京都大学, 医学研究科, 助手 2002: 京都大学, 医学研究科, 助教授
Review Section/Research Field	Principal Investigator Basic Section 55010:General surgery and pediatric surgery-related / General surgery / Digestive surgery Except Principal Investigator General surgery / Digestive surgery
Keywords	Principal Investigator 肝虚血再灌流障害 / メタボローム解析 / 肝移植 / 肝臓外科 / 絶食 / TLR-4 / 肝臓 / ERAS / 5-アミノレブリン酸 / 体内時計 … More / 概日リズム / 肝虚血再還流障害 / βヒドロキシ酪酸 / アセチル化ヒストン / FOXO1 / 食事制限 / HMGB－１ / D1分画 / HMGB-1 / トロンボモジュリン / Galectin-9 / TIM / 虚血再灌流障害 / マクロファージ / TIM-3 / T細胞 / 虚血再還流障害 / Tim-3 / galectin-9 … More Except Principal Investigator ROCK / Rho kinase inhibitor / hepatic microcirculation / hepatic stellate cell / 虚血再潅流障害 / 肝不全 / Rho kinase阻害剤 / 生体顕微鏡 / 星細胞 / 肝微小循環 / PDTC / NKH477 / reperfusion injury / ischemia / 肝切除 / CHAP31 / FR901228 / Trichostatin A / PEG10 / SIAH1 / LOH / enndotoxin / Y-27632 / Liver fibrosis / Intravital microscopyu / Liver failure / 肝障害 / エンドトキシン / 肝線維化 / 類洞 / hDAF / 遺伝子導入ブタ / DAF / 人工肝臓 / molecular chaperon / hepatic sinusoidal blood flow / hepatic sinusoidal cells / cirrhosis / hepatectomy / 分子シャペロン / 肝類洞血流 / 肝類洞壁細胞 / 虚血再灌流障害 / 肝硬変 / Defense system / Liver protection / PDE-III inhibitor / Olprinone / Milrinone / ischemia-reperfusion injury / 肝微小環境 / adenylate cyclase stimulator / 肝虚血再潅流障害 / 細胞内シグナル伝達 / PDEIII inhibitor / protein kinase A / cvclic AMP / HO-1 / cAMP / 肝阻血再灌流障害 / PDE / 生体防御 / 肝保護 / PDEIII阻害剤 / オルプリノン / ミルリノン / 肝虚血再灌流障害 / liver failure / N-acetylcisteine / intravital microscopy / thioredoxin / 肝腺維化 / 急性肝不全 / 肝繊維化 / N-アセチルシステイン / ROCK阻害剤 / チオレドキシン / Heat shock protein / Gene expression / Gene transduction / Histone deacetylase / Stress response / TrichostatinA / HSP / 遺伝子発現 / 遺伝子導入 / HDAC / ストレス応答 / Lymph node metastasis / Rucurrence / TaqMan PCR / cDNA microarray / Gastric cancer / Hepatocellular carcinoma / 肝癌細胞 / リンパ節転移 / 再発 / TapMan PCR / マイクロアレイ / 胃癌 / 肝細胞癌 / 類洞壁細胞 / Transgenic pig / Complement / Liver / Kupffer cell / Xenoperfusion / 体外灌流 / リンパ球表面抗原 / フローサイトメトリー / 異種反応性自然抗体 / 溶血 / 補体抑制蛋白 / 異種免疫反応 / 補体 / 肝臓 / Kupffer細胞 / 異種灌流 / PREV / transgenic pig / baboon / xenogeneic liver / extracorperal live perfusion / liver assist device / レトロウイルス / ブタ / IgY / レトロウィルス / 体外異種肝灌流 / ブタ内因性レトロウイルス / ヒヒ / 異種肝臓 / 体外肝灌流 / Alloreactive antibody / 二次的リンパ組織 / 抗asialo GM1抗体 / CD8^+asialo GM1^+ T細胞 / alyマウス / 抗原提示 / 同種皮膚移植 / 二次リンパ組織 Less

The involvement of circadian rhythm in liver ischemia-reperfusion injuryPrincipal Investigator
- Principal Investigator
  
  Terajima Hiroaki
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  The Tazuke Kofukai
The elucidation of mechanism of liver ischemia and reperfusion injury by diet restrictionPrincipal Investigator
- Principal Investigator
  
  Terajima Hiroaki
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  The Tazuke Kofukai
The elucidation for the suppressive effect of thrombomodulin in liver ischemia and reperfusion injuryPrincipal Investigator
- Principal Investigator
  
  TERAJIMA Hiroaki
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  The Tazuke Kofukai
The elucidation of novel T cell function in innate immunity-dominated liver tissue damage.Principal Investigator
- Principal Investigator
  
  TERAJIMA Hiroaki
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Digestive surgery
- Research Institution
  The Tazuke Kofukai
Development of perioperative management for hepatic resection based on the stellate cell function
- Principal Investigator
  
  SHIMAHARA Yasuyuki
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General surgery
- Research Institution
  Kyoto University
Research of the intracellular transmission mechanism of the information concerning stress response
- Principal Investigator
  
  YAMAMOTO Yuzo
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Akita University
  Kyoto University
Resarch on trial to suppress surgical in cirrhotic liver by modulating activation of hepatic sinusoidal cells.
- Principal Investigator
  
  HASEGAWA Suguru, 山岡義生
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  KYOTO UNIVERSITY
抗原堤示の場としての二次的リンパ組織の意義の解明と免疫寛容誘導への基礎的検討
- Principal Investigator
  
  IWAO Ikai
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  General surgery
- Research Institution
  Kyoto University
The research to establish the orader-made therapy system for hepatocellular carcinoma patients by use of genome-wide microarray database
- Principal Investigator
  
  YAMAOKA Yoshio
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Digestive surgery
- Research Institution
  KYOTO UNIVERSITY
Regulation of hepatic micro circulation by hepatic stellate cell-Application of NAC to liver failure
- Principal Investigator
  
  SHIMAHARA Yasuyuki
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General surgery
- Research Institution
  KYOTO UNIVERSITY
The research for the amplification of stress response by modification of the nucleosomal conformation
- Principal Investigator
  
  YAMAMOTO Yuzo
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  KYOTO UNIVERSITY
Strategy for Liver Failure by Regulating Hepatic Microcirculation through Hepatic Stellate Cell Activatity
- Principal Investigator
  
  SHIMAHARA Yasuyuki
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General surgery
- Research Institution
  KYOTO UNIVERSITY
The investigation of the mechanism of xenogeneic immunoreaction and its control…Examination from the organ specificity of the liver in xenotrnaplantation…
- Principal Investigator
  
  IKAI Iwao
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General surgery
- Research Institution
  KYOTO UNIVERSITY
Infectious and immunological evaluation of xenogeneic extracorporeal liver perfusion and preclinical study
- Principal Investigator
  
  YAMAOKA Yoshiro
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  General surgery
- Research Institution
  KYOTO UNIVERSITY

All 2020 2019 2018 2017 2015 2003 2002

All Journal Article Presentation

[Journal Article] Up-regulation of FOXO1 and reduced inflammation by β-hydroxybutyric acid are essential diet restriction benefits against liver injury2019
- Author(s)
  Miyauchi Tomoyuki、Uchida Yoichiro、Kadono Kentaro、Hirao Hirofumi、Kawasoe Junya、Watanabe Takeshi、Ueda Shugo、Okajima Hideaki、Terajima Hiroaki、Uemoto Shinji
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 116 Issue: 27 Pages: 13533-13542
- DOI
  10.1073/pnas.1820282116
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08609
[Journal Article] Thrombomodulin attenuates inflammatory damage due to liver ischemia and reperfusion injury in mice in Toll-like Receptor 4-dependent manner2017
- Author(s)
  K. Kadono, Y. Uchida, H. Hirao, T. Miyauchi, T. Watanabe, T. Iida, S. Ueda, A. Kanazawa, A. Mori, H. Okajima, H. Terajima, S. Uemoto
- Journal Title
  
  American J. of Transplantation
  
  Volume: 17 Issue: 1 Pages: 69-80
- DOI
  10.1111/ajt.13991
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-24111009, KAKENHI-PROJECT-15K10041
[Journal Article] The protective function of galectin-9 in liver ischemia and reperfusion injury in mice.2015
- Author(s)
  Hirofumi Hirao, Yoichiro Uchida, Kentaro Kadono, Hirokazu Tanaka, Toshiro Niki, Akira Yamauchi, Koichiro Hata, Takeshi Watanabe, Hiroaki Terajima, Shinji Uemoto
- Journal Title
  
  Liver Transplantation
  
  Volume: 21 Issue: 7 Pages: 969-981
- DOI
  10.1002/lt.24159
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K10177, KAKENHI-ORGANIZER-24111001, KAKENHI-PROJECT-25460592, KAKENHI-PROJECT-25670590, KAKENHI-PLANNED-24111009
[Journal Article] Reduction of hepatic ischemia/reperfusion-induced injury by a specifi ROCK/Rho kinase inhibitor Y-27632.2003
- Author(s)
  F.Ikeda, H.Terajima, Y.Shimahara, T.Kondo, Y.Yamaoka
- Journal Title
  
  J Surg Res 109(2)
  
  Pages: 155-160
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370355
[Journal Article] Significance of serum type IV collagen level of hepatectomized patients with chronic liver damage.2002
- Author(s)
  Y.Shimahara, N.Yamamoto, N.Uyama, H.Okuyama, H.Momoi, T.Kamikawa, H.Terajima, Y.Iimuro, Y.Yamamoto, I.Ikai, F.Kushihata, H.Kiyochi, N.Kobayashi, Y.Yamaoka
- Journal Title
  
  World J Surg 26(4)
  
  Pages: 451-456
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370355
[Presentation] Current situation in postoperative adjuvant chemotherapy and perioperative nutritional management for the treatment of pancreatic cancer2020
- Author(s)
  Yoichiro Uchida,Ryo Kamimura,Tomohiro Okamoto,Takayuki Kawai,Kohta Iguchi,Hiroaki Terajima
- Organizer
  14th World Congress of the International Hepato-Pacreato-Biliary Association
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08609
[Presentation] 肝臓外科手術における短期食事制限の有用性－基礎的見地からの検討－2020
- Author(s)
  内田洋一朗,宮内智之,川添准矢,嵯峨謙一,寺嶋宏明,上本伸二
- Organizer
  第57回日本外科代謝栄養学会
- Data Source
  KAKENHI-PROJECT-18K08609
[Presentation] Our trial to develop academic surgeon2020
- Author(s)
  Yoichiro Uchida,Hiroaki Terajima,Junya Kawasoe,Kenichi Saga,Tomoyuki Miyauchi,Shugo Ueda,Shinji Uemoto
- Organizer
  第75回日本消化器外科学会総会
- Data Source
  KAKENHI-PROJECT-18K08609
[Presentation] Thrombomodulin suppresses inflammatory damage due to liver ischemia and reperfusion injury in mice in TLR-4 dependent manner2018
- Author(s)
  Kentaro Kadono,Yoichiro Uchida, Akimori Miki, Ryo Ohno, Tomoyuki Miyauchi, Tomohiro Okamoto, Ryo Kamimura, Masashi Horiguchi, Meiki Fukuda, Takeshi Watanabe, Shugo Ueda, Hiroaki Terajima
- Organizer
  The 53rd Congress of the European Society for Surgical Research
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10041
[Presentation] トロンボモジュリンによる肝虚血再灌流障害の改善とその作用機序の解明2017
- Author(s)
  門野賢太郎、内田洋一朗、平尾浩史、宮内智之、堀口雅史、上田修吾、金澤旭宣、寺嶋宏明、岡島英明、上本伸二
- Organizer
  第117回日本外科学会総会
- Data Source
  KAKENHI-PROJECT-15K10041
[Presentation] 肝虚血再灌流障害と自然免疫の新しいメカニズムの解明―T cell Macrophage Cross-Talk―2015
- Author(s)
  内田洋一朗、平尾　浩史、門野　賢太郎、田中　宏和、吉冨　摩美、飯田　拓、上田　修吾、金澤　旭宣、上本　伸二、寺嶋　宏明
- Organizer
  第115回日本外科学会定期学術集会
- Place of Presentation
  名古屋国際会議場（愛知県名古屋市）
- Year and Date
  2015-04-16
- Data Source
  KAKENHI-PROJECT-25670590
[Presentation] 当科における胆道癌に対する肝膵同時切除の治療成績の検討2015
- Author(s)
  内田洋一朗、寺嶋宏明、松原弘侑、後藤徹、岩村宣亜、飯田拓
- Organizer
  第27回肝胆膵外科学会
- Place of Presentation
  ホテルグランパシフィック LE DAIBA （東京都港区）
- Year and Date
  2015-06-11
- Data Source
  KAKENHI-PROJECT-15K10041

1. YAMAOKA Yoshiro (90089102)

# of Collaborated Projects: 10 results

# of Collaborated Products: 2 results
2. IWAO Ikai (60263084)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
3. YAMAMOTO Yuzou (70281730)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
4. UCHIDA Yoichiro (30597745)

# of Collaborated Projects: 4 results

# of Collaborated Products: 9 results
5. YAMAMOTO Naritaka (30253298)

# of Collaborated Projects: 4 results

# of Collaborated Products: 1 results
6. KAWADA Norihumi (30271191)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
7. SHIMAHARA Yasuyuki (30196498)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
8. WATANABE Takeshi (40028684)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
9. 山内清明 (00291427)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
10. 岡島英明 (20308604)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
11. SATOH Segi (00303834)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. NAKAMURA Hajime (70303914)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. MIYAZAWA Hideaki (10323148)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. SATO Tsutomu (90235367)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. HASEGAWA Suguru (10362500)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. HATANO Etsurou (80359801)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. KADONO Kentaro (10816094)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
18. 飯室勇二 (30252018)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 宮内智之 (10852303)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. YAMAMOTO Koshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. NISHIKAWA Yoshiki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. HIRAO Hirofumi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 渡辺武

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results

Terajima Hiroaki 寺嶋 宏明

TERAJIMA Hiroaki 寺嶋 宏明

寺島 宏明 テラシマ ヒロアキ

Research Projects

Research Products

Co-Researchers

The involvement of circadian rhythm in liver ischemia-reperfusion injuryPrincipal Investigator

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Review Section

Research Institution

The elucidation of mechanism of liver ischemia and reperfusion injury by diet restrictionPrincipal Investigator

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Research Institution

The elucidation for the suppressive effect of thrombomodulin in liver ischemia and reperfusion injuryPrincipal Investigator

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The elucidation of novel T cell function in innate immunity-dominated liver tissue damage.Principal Investigator

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Terajima Hiroaki 寺嶋宏明

TERAJIMA Hiroaki 寺嶋宏明

寺島宏明テラシマヒロアキ

[Presentation] 肝臓外科手術における短期食事制限の有用性－基礎的見地からの検討－2020