Okamura Nobuyuki 岡村信行

… Alternative Names

OKAMURA Nobuyuki 岡村信行

岡本信行オカモトノブユキ

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Researcher Number	40361076
Other IDs
External Links
Affiliation (Current)	2025: 東北医科薬科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2016 – 2024: 東北医科薬科大学, 医学部, 教授 2015: 東北大学, 大学院医学系研究科, 准教授 2012 – 2015: 東北大学, 医学(系)研究科(研究院), 准教授 2014: 東北大学, 医学系研究科, 准教授 2009 – 2011: Tohoku University, 大学院・医学系研究科, 准教授 … More 2010: Tohoku University, 大学院・医学系・研究科, 准教授 2009: 東北大学, 大学院・医学系研究科, 助教 2008: Tohoku University, 大学院・医学系研究科, 講師 2008: 東北大学, 大学院医学系研究科, 講師 2007: Tohoku University, Graduate School of Medicine, Assistant Professor 2005 – 2006: 東北大学, 大学院医学系研究科, 助手 2003 – 2006: 東北大学, 大学院・医学系研究科, 助手 Less
Review Section/Research Field	Principal Investigator Radiation science / Biological Sciences / Basic Section 52040:Radiological sciences-related / Medium-sized Section 52:General internal medicine and related fields Except Principal Investigator Radiation science / Applied pharmacology / Basic Section 52040:Radiological sciences-related / Neurology / Basic Section 52020:Neurology-related / Medium-sized Section 52:General internal medicine and related fields … More / Neurochemistry/Neuropharmacology / General pharmacology / General pharmacology / Cognitive science Less
Keywords	Principal Investigator PET / アルツハイマー病 / 老化 / アミロイドβ蛋白 / アストロサイト / 脳神経疾患 / 放射線 / イメージング / 神経炎症 / バイオマーカー … More / 痴呆 / 神経科学 / モノアミン酸化酵素 / タウ / αシヌクレイン / 認知症 / 認知 / 老人斑 / 神経変性疾患 / アミロイド / アストログリオーシス / PETプローブ / 分子イメージング / 画像診断 / グリオーシス / 進行性核上性麻痺 / パーキンソン病 / 感情 / 注意 / fMRI / プローブ / 神経原線維変化 / タウ蛋白 … More Except Principal Investigator PET / アルツハイマー病 / 分子イメージング / ヒスタミン / 抗ヒスタミン薬 / タウ / 認知症 / α-シヌクレイン / [11C]BF-227 / パーキンソン病 / ノックアウトマウス / 神経変性疾患 / アセチルコリンエステラーゼ / 慢性低酸素 / オートファジー障害 / MRI / 鉄 / オートファジー / 多発性硬化症 / モノアミン酸化酵素B / グリオーシス / ミスフォールディング / [11C] BF-227 / 18F / イメージング / in-air micro PIXE / neurogeneses / atypical anti-psychotics / memory / learning / childhood / stress / mice / histaminergic neuron system / 大気マイクロPUXE / 記憶・学習 / 大気マイクロPIXE / 神経新生 / 非定型抗精神病薬 / 学習・記憶 / 幼児期 / ストレス / マウス / ヒスタミン神経系 / amyloid Aβ proteins / Antihistamines / Histamine 1-11 receptors / Positron Emission Tomography (PET) / Molecular imaging / Alzheimer disease / translational research / Acetylcholinesterase / アミロイドAβ / ヒスタミンH1受容体占拠率 / トランスレーショナル・リサーチ / Positron Emission Tomography(PET) / Schizouhrenia / gene knockout mice / Antinocicention / Pain perception / Adenosine / Histamine / Orexins / モルヒネ / 脳血流量 / 覚醒 / ハロペリドール / ドキセピン / うつ病 / 神経性食欲低下症 / activity stress / 痛み / 統合失調症 / 遺伝子ノックアウトマウス / 鎮痛作用 / 痛みの受容 / アデノシン / オレキシン / BF-227 / アミロイド / 画像診断 / statistical analysis / Amyloid / Alzheimer's disease / 統計画像解析 / アミロイドイメージング / 多系統萎縮症 / 注意力 / ドネペジル / 中枢神経系 / ヒト臨床研究 / 小動物用PET/CT / 分子イメニジング / 膵ランゲルハンス島β細胞 / H1受容体占拠率 / PMAT / H3受容体 / internalization / Dynamin / ヒスタミンH2受容体 / Rac / small GTPase Rho / 性差 / プロテオミクス / ヒスタミンH4受容体 / ヒスタミンH1受容体 / ヒスタミン受容体 / 和音 / 脳イメージング / 長調・単調 / 神経美学 / C11-ドキセ / フェキソフェナジン / C11-ドネペジル / H_1受容体占拠率 / P糖タンパク / 脳血液関門 / 遺伝子多型 / P-糖タンパク / ブレーキ反応時間 / 自動車運転試験 Less

[18F]SMBT-1を用いた多発性硬化症における反応性アストログリオーシス評価
- Principal Investigator
  
  藤盛寿一
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Tohoku Medical and Pharmaceutical University
Elucidation of the pathophysiology of Alzheimer's disease by a novel tau-specific PET tracer, [F18]SNFT-1
- Principal Investigator
  
  金田朋洋
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Tohoku University
認知症におけるオートファジー障害の病態解明とPADREによる超早期画像診断法の開発
- Principal Investigator
  
  瀧靖之
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Tohoku University
Development of diagnostic technique for detection of non-Alzheimer degenerative diseases by visualization of reactive astrocytesPrincipal Investigator
- Principal Investigator
  
  岡村信行
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Tohoku Medical and Pharmaceutical University
神経炎症を生体画像化する新規画像バイオマーカーの開発研究Principal Investigator
- Principal Investigator
  
  岡村信行
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  Tohoku Medical and Pharmaceutical University
Development of protein-specific PET molecular imaging in neurodegenerative disorders
- Principal Investigator
  
  Yanai Kazuhiko
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  Tohoku University
Imaging neurofibrillary tangles and astrogliosis for the clarification of the pathogenesis of Alzheimer's diseasePrincipal Investigator
- Principal Investigator
  
  Okamura Nobuyuki
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Tohoku Medical and Pharmaceutical University
Search of conformation-specific PET probePrincipal Investigator
- Principal Investigator
  
  OKAMURA Nobuyuki
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Radiation science
- Research Institution
  Tohoku Medical and Pharmaceutical University
Development of novel imaging biomarker using highly-sensitive tau PET probesPrincipal Investigator
- Principal Investigator
  
  OKAMURA Nobuyuki
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Radiation science
- Research Institution
  Tohoku Medical and Pharmaceutical University
  Tohoku University
In vivo visualization of synuclein deposits in Parkinson's disease and its clinical applicability
- Principal Investigator
  
  Kikuchi Akio
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Tohoku University
Development of alpha-synuclein selective PET probePrincipal Investigator
- Principal Investigator
  
  OKAMURA Nobuyuki
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Radiation science
- Research Institution
  Tohoku University
Precise evaluation and optimization of the THK probe for tau imaging
- Principal Investigator
  
  FURUMOTO SHOZO
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Radiation science
- Research Institution
  Tohoku University
Optimization of voxel-based statistical analyses for amyloid PET of Alzheimer's disease
- Principal Investigator
  
  KANETA Tomohiro
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  Tohoku University
Clinical application of tau PET probesPrincipal Investigator
- Principal Investigator
  
  OKAMURA Nobuyuki
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Radiation science
- Research Institution
  Tohoku University
In vivo visualization of synuclein deposition in multiple system atrophy and its clinical applicability
- Principal Investigator
  
  KIKUCHI Akio
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Tohoku University
Integrated research of histamine system from molecular to wholeanimals and humans using leading-edge technologies
- Principal Investigator
  
  YANAI Kazuhiko
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied pharmacology
- Research Institution
  Tohoku University
Therapeutic effect of donepezil administration for patients with Alzheimer's disease as shown by [11C]-donepezil PET
- Principal Investigator
  
  MEGURO Kenichi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  Tohoku University
PETを用いた分子イメージングによる神経変性疾患の病態解明Principal Investigator
- Principal Investigator
  
  岡村信行
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
Development of amyloid and tau imaging probes for early diagnosis of dementiaPrincipal Investigator
- Principal Investigator
  
  OKAMURA Nobuyuki
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  Tohoku University
Molecular Neuropharmacology on histamine system : From basic to clinical investigation on unsolved issues
- Principal Investigator
  
  YANAI Kazuhiko
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  Tohoku University
分子イメージングおよび脳機能イメージングを用いた認知機能障害発現機構の解明Principal Investigator
- Principal Investigator
  
  岡村信行
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
短調美と長調美の特質と脳内基盤の差異
- Principal Investigator
  
  行場次朗
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Cognitive science
- Research Institution
  Tohoku University
アミロイドイメージングによるアルツハイマー病診断・治療評価系の確立Principal Investigator
- Principal Investigator
  
  岡村信行
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Radiation science
- Research Institution
  Tohoku University
The effects of stress exposure in weanling mice on cognitive function and neurogenesis: the role of histaminergic neuron systems
- Principal Investigator
  
  SAKURAI Eiko
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Tohoku University
PETによる分子・機能イメージングを組み合わせたヒトの認知・注意・感情の機能研究Principal Investigator
- Principal Investigator
  
  岡村信行
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
A study of the histamine neuron system: Its correlation to newly-discovered hypothalamic peptides.
- Principal Investigator
  
  YANAI Kazuhiko
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied pharmacology
- Research Institution
  Tohoku University
脳内アミロイドβ蛋白およびタウ蛋白のPETイメージング技術の開発Principal Investigator
- Principal Investigator
  
  岡村信行
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Radiation science
- Research Institution
  Tohoku University
PETと遺伝子多型を組み合わせたヒト脳における薬物透過性と脳機能研究法の開発
- Principal Investigator
  
  YANAI Kazuhiko
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Applied pharmacology
- Research Institution
  Tohoku University
A study of the histamine neuron system : Its correlation to newly-discovered hypothalamic peptides.
- Principal Investigator
  
  YANAI Kazuhiko
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  Tohoku University

[Book] Aging Mechanisms II Longevity, Metabolism, and Brain Aging2022
- Author(s)
  Nobuyuki Okamura, Ryuichi Harada
- Total Pages
  17
- Publisher
  Springer
- ISBN
  9789811679773
- Data Source
  KAKENHI-PROJECT-18H02771
[Book] Neuroimaging Diagnosis for Alzheimer’s Disease and Other Dementias.2017
- Author(s)
  Okamura N.
- Total Pages
  279
- Publisher
  Springer
- ISBN
  9784431551331
- Data Source
  KAKENHI-PROJECT-16K15570
[Book] Neuroimaging Diagnosis for Alzheimer’s Disease and Other Dementias.2017
- Author(s)
  Okamura N, Harada R, Furumoto S, Kudo Y.
- Total Pages
  279
- Publisher
  Springer
- ISBN
  9784431551331
- Data Source
  KAKENHI-PROJECT-15H04900
[Book] Annual Review神経2012
- Author(s)
  岡村信行
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-23390297
[Book] 抗ヒスタミン薬編2012
- Author(s)
  宮地良樹、岡本美孝、谷内一彦
- Publisher
  メディカルレビュー社
- Data Source
  KAKENHI-PROJECT-21390171
[Book] "Nano-Biomedical Engineering 2009 : Proceedings of the Tohoku University Global Centre of Excellence Programme" (Editor : Takami Yamaguchi)2009
- Author(s)
  Yanai K, Okamura N, Iwata R, Tashiro M.
- Total Pages
  469
- Publisher
  Molecular imaging and its application to drug development at Tohoku University.
- Data Source
  KAKENHI-PROJECT-19390061
[Book] よくわかって役に立つ痴呆症のすべて2005
- Author(s)
  岡村信行, 工藤幸司
- Total Pages
  279
- Publisher
  永井書店
- Data Source
  KAKENHI-PROJECT-16790714
[Book] 見て診て学ぶ痴呆の画像診断2004
- Author(s)
  岡村信行
- Total Pages
  322
- Publisher
  永井書店
- Data Source
  KAKENHI-PROJECT-16790714
[Journal Article] 2.Amyloid accumulation in cases of suspected comorbid cerebral amyloid angiopathy and isolated cortical venous thrombosis.2024
- Author(s)
  Kobayashi Y, Hiraoka K, Itabashi R, Saito T, Kawabata Y, Yazawa Y, Funaki Y, Furumoto S, Okamura N, Furukawa K, Ishiki A, Arai H, Yanai K, Tashiro M, Sekijima Y.
- Journal Title
  
  J Neurol Sci
  
  Volume: 15 Pages: 122892-122892
- DOI
  10.1016/j.jns.2024.122892
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15647, KAKENHI-PROJECT-22KK0123, KAKENHI-PROJECT-23K07069, KAKENHI-PROJECT-23K21420
[Journal Article] 4.Preclinical Characterization of the Tau PET Tracer [18F]SNFT-1: Comparison of Tau PET Tracers.2023
- Author(s)
  Harada R, Lerdsirisuk P, Shimizu Y, Yokoyama Y, Du Y, Kudo K, Ezura M, Ishikawa Y, Iwata R, Shidahara M, Ishiki A, Kikuchi A, Hatano Y, Ishihara T, Onodera O, Iwasaki Y, Yoshida M, Taki Y, Arai H, Kudo Y, Yanai K, Furumoto S, Okamura N.
- Journal Title
  
  J Nucl Med
  
  Volume: 64 Issue: 9 Pages: 1495-1501
- DOI
  10.2967/jnumed.123.265593
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15647, KAKENHI-PROJECT-22KK0123, KAKENHI-PROJECT-20K07879, KAKENHI-PROJECT-23K06947, KAKENHI-PROJECT-23K07069
[Journal Article] Multitracer Approach to Understanding the Complexity of Reactive Astrogliosis in Alzheimer’s Brains2023
- Author(s)
  Fontana Igor C.、Kumar Amit、Okamura Nobuyuki、Nordberg Agneta
- Journal Title
  
  ACS Chemical Neuroscience
  
  Volume: 15 Issue: 2 Pages: 328-336
- DOI
  10.1021/acschemneuro.3c00646
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22KK0123, KAKENHI-PROJECT-23K07069
[Journal Article] In vivo imaging of astrogliosis by PET2023
- Author(s)
  Harada Ryuichi、Okamura Nobuyuki
- Journal Title
  
  Folia Pharmacologica Japonica
  
  Volume: 158 Issue: 1 Pages: 26-29
- DOI
  10.1254/fpj.22091
- ISSN
  0015-5691, 1347-8397
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-18H02771
[Journal Article] Evaluation of 18F labeled glial fibrillary acidic protein binding nanobody and its brain shuttle peptide fusion proteins using a neuroinflammation rat model2023
- Author(s)
  Morito Takahiro、Harada Ryuichi、Iwata Ren、Ishikawa Yoichi、Okamura Nobuyuki、Kudo Yukitsuka、Furumoto Shozo、Yanai Kazuhiko、Tashiro Manabu
- Journal Title
  
  PLOS ONE
  
  Volume: 18 Issue: 6 Pages: 0287047-0287047
- DOI
  10.1371/journal.pone.0287047
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22KK0123, KAKENHI-PROJECT-23K07069, KAKENHI-PROJECT-21K19320, KAKENHI-PROJECT-23K21420, KAKENHI-PROJECT-23K24070
[Journal Article] A Novel Near-Infrared Fluorescence Probe THK-565 Enables In Vivo Detection of Amyloid Deposits in Alzheimer’s Disease Mouse Model2023
- Author(s)
  Naganuma Fumito、Murata Daiki、Inoue Marie、Maehori Yuri、Harada Ryuichi、Furumoto Shozo、Kudo Yukitsuka、Nakamura Tadaho、Okamura Nobuyuki
- Journal Title
  
  Molecular Imaging and Biology
  
  Volume: 25 Issue: 6 Pages: 1115-1124
- DOI
  10.1007/s11307-023-01843-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22KK0123, KAKENHI-PROJECT-22K07373, KAKENHI-PROJECT-23K07069, KAKENHI-PROJECT-23K08342, KAKENHI-PROJECT-23K24070
[Journal Article] Effects of the APOEe4 Allele on the Relationship Between Tau and Amyloid-β in Early- and Late-Onset Alzheimer’s Disease2023
- Author(s)
  Kang Jae Myeong、Shin Jeong-Hyeon、Kim Woo-Ram、Seo Seongho、Seo Haeun、Lee Sang-Yoon、Park Kee Hyung、Na Duk L.、Okamura Nobuyuki、Seong Joon-Kyoung、Noh Young
- Journal Title
  
  Journal of Alzheimer's Disease
  
  Volume: 94 Issue: 3 Pages: 1233-1246
- DOI
  10.3233/jad-230339
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22KK0123, KAKENHI-PROJECT-23K07069
[Journal Article] In vivo [18F]THK-5351 imaging detected reactive astrogliosis in argyrophilic grain disease with comorbid pathology: A clinicopathological study2023
- Author(s)
  Ryota Kobayashi , Tadaho Nakamura, Fumito Naganuma, Ryuichi Harada, Daichi Morioka, Masafumi Kanoto, Shozo Furumoto, Yukitsuka Kudo, Takanobu Kabasawa, Koichi Otani, Mitsuru Futakuchi , Shinobu Kawakatsu, Nobuyuki Okamura
- Journal Title
  
  J Neuropathol Exp Neurol .
  
  Volume: - Issue: 5 Pages: 427-437
- DOI
  10.1093/jnen/nlad018
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08043, KAKENHI-PROJECT-22K07373, KAKENHI-PROJECT-22K07552, KAKENHI-PROJECT-22KK0123, KAKENHI-PROJECT-18H02771, KAKENHI-PROJECT-20K07922, KAKENHI-PROJECT-20K09204, KAKENHI-PROJECT-19KK0212, KAKENHI-PROJECT-23K06646, KAKENHI-PROJECT-23K07129, KAKENHI-PROJECT-20K07619
[Journal Article] Middle Cerebellar Peduncle in Early Stage of Multiple System Atrophy: A THK5351 PET Study2022
- Author(s)
  Horimoto Yoshihiko、Hayashi Emi、Okamura Nobuyuki、Inagaki Aki、Yasui Keizo、Uchida Yuto、Ito Yoshihiro、Iida Akihiko、Sato Chikako、Anan Chise、Suzuki Ayuko、Tajima Toshihisa、Hibino Hiroaki、Kabasawa Hidehiro、Matsukawa Noriyuki
- Journal Title
  
  Movement Disorders
  
  Volume: 37 Issue: 9 Pages: 1957-1959
- DOI
  10.1002/mds.29143
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22KK0123, KAKENHI-PROJECT-18H02771
[Journal Article] Patterns of Distribution of 18F-THK5351 Positron Emission Tomography in Alzheimer’s Disease Continuum2022
- Author(s)
  Nihashi Takashi、Sakurai Keita、Kato Takashi、Iwata Kaori、Kimura Yasuyuki、Ikenuma Hiroshi、Yamaoka Akiko、Takeda Akinori、Arahata Yutaka、Washimi Yukihiko、Suzuki Keisuke、Bundo Masahiko、Sakurai Takashi、Okamura Nobuyuki、Yanai Kazuhiko、Ito Kengo、Nakamura Akinori、MULNIAD Study Group
- Journal Title
  
  Journal of Alzheimer's Disease
  
  Volume: 85 Issue: 1 Pages: 223-234
- DOI
  10.3233/jad-215024
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02771, KAKENHI-PROJECT-19KK0212
[Journal Article] The Role of Chirality of [18F]SMBT-1 in Imaging of Monoamine Oxidase-B2022
- Author(s)
 Harada Ryuichi、Shimizu Yuki、Du Yiqing、Ishikawa Yoichi、Iwata Ren、Kudo Yukitsuka、Yanai Kazuhiko、Okamura Nobuyuki、Furumoto Shozo
- Journal Title
 
 ACS Chemical Neuroscience
 
 Volume: 13 Issue: 3 Pages: 322-329
- DOI
 10.1021/acschemneuro.1c00655
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-18H02771, KAKENHI-PROJECT-20K08043, KAKENHI-PROJECT-19KK0212, KAKENHI-PROJECT-20H03614, KAKENHI-PROJECT-23K21420
[Journal Article] Age-related increase of monoamine oxidase B in amyloid-negative cognitively unimpaired elderly subjects.2022
- Author(s)
  Sakurai K, Nihashi T, Kimura Y, Iwata K, Ikenuma H, Arahata Y, Okamura N, Yanai K, Akagi A, Ito K, Kato T, Nakamura A, Group MS.
- Journal Title
  
  Ann Nucl Med
  
  Volume: 36(8) Issue: 8 Pages: 777-784
- DOI
  10.1007/s12149-022-01760-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19KK0212
[Journal Article] Imaging of Reactive Astrogliosis by Positron Emission Tomography2022
- Author(s)
  Harada Ryuichi、Furumoto Shozo、Kudo Yukitsuka、Yanai Kazuhiko、Villemagne Victor L.、Okamura Nobuyuki
- Journal Title
  
  Frontiers in Neuroscience
  
  Volume: 16 Pages: 807435-807435
- DOI
  10.3389/fnins.2022.807435
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02771, KAKENHI-PROJECT-20K08043, KAKENHI-PROJECT-19KK0212, KAKENHI-PROJECT-23K21420, KAKENHI-PROJECT-23K24070
[Journal Article] Assessing reactive astrogliosis with 18F-SMBT-1 across the Alzheimer’s disease spectrum2022
- Author(s)
  Villemagne Victor L、Harada Ryuichi、Dore Vincent、Furumoto Shozo、Mulligan Rachel、Kudo Yukitsuka、Burnham Samantha、Krishnadas Natasha、Bourgeat Pierrick、Xia Ying、Laws Simon、Bozinovski Svetlana、Huang Kun、Ikonomovic Milos D、Fripp Jurgen、Yanai Kazuhiko、Okamura Nobuyuki、Rowe Christopher C
- Journal Title
  
  Journal of Nuclear Medicine
  
  Volume: - Issue: 10 Pages: 1560-1569
- DOI
  10.2967/jnumed.121.263255
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08043, KAKENHI-PROJECT-19KK0212, KAKENHI-PROJECT-22KK0123, KAKENHI-PROJECT-18H02771
[Journal Article] First-in-human evaluation of 18F-SMBT-1, a novel 18F-labeled MAO-B PET tracer for imaging reactive astrogliosis2022
- Author(s)
 Villemagne Victor L、Harada Ryuichi、Dore Vincent、Furumoto Shozo、Mulligan Rachel、Kudo Yukitsuka、Burnham Samantha、Krishnadas Natasha、Bozinovski Svetlana、Huang Kun、Lopresti Brian J、Yanai Kazuhiko、Rowe Christopher C、Okamura Nobuyuki
- Journal Title
 
 Journal of Nuclear Medicine
 
 Volume: - Issue: 10 Pages: 1551-1559
- DOI
 10.2967/jnumed.121.263254
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
 KAKENHI-PROJECT-20K08043, KAKENHI-PROJECT-19KK0212, KAKENHI-PROJECT-22KK0123, KAKENHI-PROJECT-18H02771
[Journal Article] Synthesis and evaluation of 2-pyrrolopyridinylquinoline derivatives as selective tau PET tracers for the diagnosis of Alzheimer's disease2021
- Author(s)
  Lerdsirisuk Pradith、Harada Ryuichi、Hayakawa Yoshimi、Shimizu Yuki、Ishikawa Yoichi、Iwata Ren、Kudo Yukitsuka、Okamura Nobuyuki、Furumoto Shozo
- Journal Title
  
  Nuclear Medicine and Biology
  
  Volume: 93 Pages: 11-18
- DOI
  10.1016/j.nucmedbio.2020.10.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08043, KAKENHI-PROJECT-20H03614, KAKENHI-PROJECT-18H02771
[Journal Article] Characterization of an APP/tau rat model of Alzheimer’s disease by positron emission tomography and immunofluorescent labeling2021
- Author(s)
  Filip Thomas、Mairinger Severin、Neddens Joerg、Sauberer Michael、Flunkert Stefanie、Stanek Johann、Wanek Thomas、Okamura Nobuyuki、Langer Oliver、Hutter-Paier Birgit、Kuntner Claudia
- Journal Title
  
  Alzheimer's Research & Therapy
  
  Volume: 13 Issue: 1 Pages: 175-175
- DOI
  10.1186/s13195-021-00916-2
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02771
[Journal Article] Identification of Heterogeneous Subtypes of Mild Cognitive Impairment Using Cluster Analyses Based on PET Imaging of Tau and Astrogliosis2021
- Author(s)
  Lee Hyun Jeong、Lee Eun-Chong、Seo Seongho、Ko Kwang-Pil、Kang Jae Myeong、Kim Woo-Ram、Seo Ha-Eun、Lee Sang-Yoon、Lee Yeong-Bae、Park Kee Hyung、Yeon Byeong Kil、Okamura Nobuyuki、Na Duk L.、Seong Joon-Kyung、Noh Young
- Journal Title
  
  Frontiers in Aging Neuroscience
  
  Volume: 12 Pages: 615467-615467
- DOI
  10.3389/fnagi.2020.615467
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02771
[Journal Article] [18F]SMBT-1を用いた反応性アストロサイトのPETイメージング2021
- Author(s)
  岡村信行，原田龍一
- Journal Title
  
  Dementia Japan
  
  Volume: 35 Pages: 339-345
- Data Source
  KAKENHI-PROJECT-18H02771
[Journal Article] 18F-THK5351 PET imaging in neurodegenerative tauopathies2021
- Author(s)
  Ezura M, Kikuchi A, Okamura N, Ishiki A, Hasegawa T, Harada R, Watanuki S, Funaki Y, Hiraoka K, Baba T, Sugeno N, Yoshida S, Kobayashi J, Kobayashi M, Tano O, Ishiyama S, Nakamura T, Nakashima I, Mugikura S, Iwata R, Taki Y, Furukawa K, Arai H, Furumoto S, Tashiro M, Yanai K, Kudo Y, Takeda A, Aoki M
- Journal Title
  
  Front Aging Neurosci
  
  Volume: 13 Pages: 761010-761010
- DOI
  10.3389/fnagi.2021.761010
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09789, KAKENHI-PROJECT-18H02771, KAKENHI-PROJECT-20H03614, KAKENHI-PROJECT-20K07830, KAKENHI-PROJECT-20K07862, KAKENHI-PROJECT-20K07879, KAKENHI-PROJECT-20K08043, KAKENHI-PROJECT-21K19320, KAKENHI-PROJECT-18K15357, KAKENHI-PROJECT-19KK0212
[Journal Article] Synthesis and pharmacokinetic characterisation of a fluorine-18 labelled brain shuttle peptide fusion dimeric affibody2021
- Author(s)
  Morito Takahiro、Harada Ryuichi、Iwata Ren、Du Yiqing、Okamura Nobuyuki、Kudo Yukitsuka、Yanai Kazuhiko
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 2588-2588
- DOI
  10.1038/s41598-021-82037-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21564, KAKENHI-PROJECT-19KK0212, KAKENHI-PROJECT-20H03614, KAKENHI-PROJECT-18H02771
[Journal Article] 18F-SMBT-1: A Selective and Reversible PET Tracer for Monoamine Oxidase-B Imaging2020
- Author(s)
  Harada Ryuichi、Hayakawa Yoshimi、Ezura Michinori、Lerdsirisuk Pradith、Du Yiqing、Ishikawa Yoichi、Iwata Ren、Shidahara Miho、Ishiki Aiko、Kikuchi Akio、Arai Hiroyuki、Kudo Yukitsuka、Yanai Kazuhiko、Furumoto Shozo、Okamura Nobuyuki
- Journal Title
  
  Journal of Nuclear Medicine
  
  Volume: 62 Issue: 2 Pages: 253-258
- DOI
  10.2967/jnumed.120.244400
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08043, KAKENHI-PROJECT-18K15357, KAKENHI-PROJECT-19KK0212, KAKENHI-PROJECT-20H03614, KAKENHI-PROJECT-17K09789, KAKENHI-PROJECT-18H02771, KAKENHI-PROJECT-20K07879
[Journal Article] 18F-THK5351 PET imaging in patients with progressive supranuclear palsy: associations with core domains and diagnostic certainty2020
- Author(s)
  Hsu Jung-Lung、Chen Shih-Hsin、Hsiao Ing-Tsung、Lu Chin-Song、Yen Tzu-Chen、Okamura Nobuyuki、Lin Kun-Ju、Weng Yi-Hsin
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 19410-19410
- DOI
  10.1038/s41598-020-76339-0
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02771
[Journal Article] [18F]THK5351 PET Imaging in Patients with Mild Cognitive Impairment2020
- Author(s)
  Jeong Hye Jin、Lee Hyon、Lee Sang-Yoon、Seo Seongho、Park Kee Hyung、Lee Yeong-Bae、Shin Dong Jin、Kang Jae Myeong、Yeon Byeong Kil、Kang Seung-Gul、Cho Jaelim、Seong Joon-Kyung、Okamura Nobuyuki、Villemagne Victor L.、Na Duk L.、Noh Young
- Journal Title
  
  Journal of Clinical Neurology
  
  Volume: 16 Issue: 2 Pages: 202-214
- DOI
  10.3988/jcn.2020.16.2.202
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02771
[Journal Article] Plasma pharmacokinetic and metabolism of [18F]THK-5317 are dependent on sex2020
- Author(s)
  Mairinger Severin、Filip Thomas、Sauberer Michael、Flunkert Stefanie、Wanek Thomas、Stanek Johann、Furtner Sara、Hutter-Paier Birgit、Okamura Nobuyuki、Kuntner Claudia
- Journal Title
  
  Nuclear Medicine and Biology
  
  Volume: 84-85 Pages: 28-32
- DOI
  10.1016/j.nucmedbio.2020.01.001
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02771
[Journal Article] Investigation of reactive astrogliosis effect on post-stroke cognitive impairment2020
- Author(s)
  Huang Kuo-Lun、Hsiao Ing-Tsung、Ho Meng-Yang、Hsu Jung-Lung、Chang Yeu-Jhy、Chang Ting-Yu、Liu Chi-Hung、Chang Chien-Hung、Wu Yi-Ming、Wu Kuan-Yi、Wey Shiaw-Pyng、Yen Tzu-Chen、Okamura Nobuyuki、Lee Tsong-Hai、Lin Kun-Ju
- Journal Title
  
  Journal of Neuroinflammation
  
  Volume: 17 Issue: 1 Pages: 308-308
- DOI
  10.1186/s12974-020-01985-0
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02771
[Journal Article] Assessment of Amyloid Deposition in Patients With Probable REM Sleep Behavior Disorder as a Prodromal Symptom of Dementia With Lewy Bodies Using PiB-PET2019
- Author(s)
  Kobayashi Ryota、Hayashi Hiroshi、Kawakatsu Shinobu、Okamura Nobuyuki、Yoshioka Masanori、Otani Koichi
- Journal Title
  
  Frontiers in Neurology
  
  Volume: 10 Pages: 671-671
- DOI
  10.3389/fneur.2019.00671
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08009, KAKENHI-PROJECT-18H02771
[Journal Article] Characterization of the binding of tau imaging ligands to melanin-containing cells: putative off-target-binding site2019
- Author(s)
  Tago Tetsuro、Toyohara Jun、Harada Ryuichi、Furumoto Shozo、Okamura Nubuyuki、Kudo Yukitsuka、Takahashi-Fujigasaki Junko、Murayama Shigeo、Ishii Kenji
- Journal Title
  
  Annals of Nuclear Medicine
  
  Volume: 33 Issue: 6 Pages: 1-8
- DOI
  10.1007/s12149-019-01344-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09813, KAKENHI-PROJECT-18K15655, KAKENHI-PROJECT-16H06277, KAKENHI-PROJECT-18K07658, KAKENHI-PROJECT-18K15538, KAKENHI-PLANNED-26117003, KAKENHI-PROJECT-18H02771
[Journal Article] Brain histamine H1 receptor occupancy after oral administration of desloratadine and loratadine2019
- Author(s)
  Nakamura Tadaho、Hiraoka Kotaro、Harada Ryuichi、Matsuzawa Takuro、Ishikawa Yoichi、Funaki Yoshihito、Yoshikawa Takeo、Tashiro Manabu、Yanai Kazuhiko、Okamura Nobuyuki
- Journal Title
  
  Pharmacology Research & Perspectives
  
  Volume: 7 Issue: 4
- DOI
  10.1002/prp2.499
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06886, KAKENHI-PROJECT-17K20083, KAKENHI-PROJECT-16H05385, KAKENHI-PROJECT-17K16753, KAKENHI-PROJECT-18K15538, KAKENHI-PROJECT-18H02771
[Journal Article] Longitudinal changes in 18F-THK5351 PET in corticobasal syndrome2019
- Author(s)
  Ezura M, Kikuchi A, Ishiki A, Okamura N, Hasegawa T, Harada R, Watanuki S, Funaki Y, Hiraoka K, Baba T, Sugeno N, Oshima R, Yoshida S, Kobayashi J, Kobayashi M, Tano O, Nakashima I, Mugikura S, Iwata R, Taki Y, Furukawa K, Arai H, Furumoto S, Tashiro M, Yanai K, Kudo Y, Takeda A, Aoki M
- Journal Title
  
  Eur J Neurol
  
  Volume: 26 Issue: 9 Pages: 1205-1211
- DOI
  10.1111/ene.13966
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09789, KAKENHI-PROJECT-17K20083, KAKENHI-PROJECT-19KK0212, KAKENHI-PROJECT-16H05385, KAKENHI-PROJECT-17K09318, KAKENHI-PROJECT-17K09744, KAKENHI-PROJECT-17K09745, KAKENHI-PROJECT-18K15538, KAKENHI-PROJECT-18H02771
[Journal Article] PET Imaging of Astrogliosis and Tau Facilitates Diagnosis of Parkinsonian Syndromes2019
- Author(s)
  Schonecker Sonja、Brendel Matthias、Palleis Carla、Beyer Leonie、Hoglinger Gunter U.、Schuh Elisabeth、Rauchmann Boris-Stephan、Sauerbeck Julia、Rohrer Guido、Sonnenfeld Stefan、Furukawa Katsutoshi、Ishiki Aiko、Okamura Nobuyuki、et al.
- Journal Title
  
  Frontiers in Aging Neuroscience
  
  Volume: 11 Pages: 249-249
- DOI
  10.3389/fnagi.2019.00249
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02771
[Journal Article] Cholinergic denervation in patients with idiopathic rapid eye movement sleep behaviour disorder2019
- Author(s)
  Gersel Stokholm M.、Iranzo A.、Ostergaard K.、Serradell M.、Otto M.、Bacher Svendsen K.、Garrido A.、Vilas D.、Fedorova T.D.、Santamaria J.、Moller A.、Gaig C.、Hiraoka K.、Brooks D.J.、Okamura N.、Borghammer P.、Tolosa E.、Pavese N.
- Journal Title
  
  European Journal of Neurology
  
  Volume: 27 Issue: 4 Pages: 644-652
- DOI
  10.1111/ene.14127
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02771
[Journal Article] Topographical Heterogeneity of Alzheimer’s Disease Based on MR Imaging, Tau PET, and Amyloid PET2019
- Author(s)
  Jeon Seun、Kang Jae Myeong、Seo Seongho、Jeong Hye Jin、Funck Thomas、Lee Sang-Yoon、Park Kee Hyung、Lee Yeong-Bae、Yeon Byeong Kil、Ido Tatsuo、Okamura Nobuyuki、Evans Alan C.、Na Duk L.、Noh Young
- Journal Title
  
  Frontiers in Aging Neuroscience
  
  Volume: 11 Pages: 211-211
- DOI
  10.3389/fnagi.2019.00211
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02771
[Journal Article] Targeting metals rescues the phenotype in an animal model of tauopathy2018
- Author(s)
  Sedjahtera Amelia、Gunawan Lydia、Bray Lisa、Hung Lin Wai、Parsons Jack、Okamura Nobuyuki、Villemagne Victor L.、Yanai Kazuhiko、Liu Xiang M.、Chan Jacky、Bush Ashley I.、Finkelstein David I.、Barnham Kevin J.、Cherny Robert A.、Adlard Paul A.
- Journal Title
  
  Metallomics
  
  Volume: 10 Issue: 9 Pages: 1339-1347
- DOI
  10.1039/c8mt00153g
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02771, KAKENHI-PLANNED-26117003
[Journal Article] Case of progressive supranuclear palsy detected by tau imaging with [18F]THK-5351 before the appearance of characteristic clinical features.2018
- Author(s)
  Shimizu S, Imabayashi E, Takenoshita N, Okamura N, Furumoto S, Kudo Y, Matsuda H, Hanyu H.
- Journal Title
  
  Geriatr Gerontol Int.
  
  Volume: 18 Issue: 3 Pages: 501-502
- DOI
  10.1111/ggi.13229
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04900, KAKENHI-PLANNED-26117003
[Journal Article] Association of deposition of tau and amyloid-β proteins with structural connectivity changes in cognitively normal older adults and Alzheimer’s disease spectrum patients.2018
- Author(s)
  Shigemoto Y, Sone D, Maikusa N, Okamura N, Furumoto S, Kudo Y, Ogawa M, Takanno H, Yokoi Y, Sakata M, Tsukamoto T, Kato K, Sato N, Matsuda H
- Journal Title
  
  Brain Behav
  
  Volume: 8 Issue: 12
- DOI
  10.1002/brb3.1145
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07779, KAKENHI-PROJECT-18H02771, KAKENHI-PLANNED-26117003
[Journal Article] [18F]THK-5351 PET imaging in early-stage semantic variant primary progressive aphasia: a report of two cases and a literature review2018
- Author(s)
  Kobayashi Ryota、Hayashi Hiroshi、Kawakatsu Shinobu、Ishiki Aiko、Okamura Nobuyuki、Arai Hiroyuki、Otani Koichi
- Journal Title
  
  BMC Neurology
  
  Volume: 18 Issue: 1 Pages: 109-109
- DOI
  10.1186/s12883-018-1115-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02771, KAKENHI-PROJECT-16K09228, KAKENHI-PROJECT-16K15570, KAKENHI-PLANNED-26117003
[Journal Article] Imaging Protein Misfolding in the Brain Using β-Sheet Ligands2018
- Author(s)
  Harada Ryuichi、Okamura Nobuyuki、Furumoto Shozo、Yanai Kazuhiko
- Journal Title
  
  Frontiers in Neuroscience
  
  Volume: 12 Pages: 585-585
- DOI
  10.3389/fnins.2018.00585
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02771, KAKENHI-PROJECT-16K15570, KAKENHI-PROJECT-18K15538, KAKENHI-PLANNED-26117003
[Journal Article] A comparison of five partial volume correction methods for Tau and Amyloid PET imaging with [(18)F]THK5351 and [(11)C]PIB.2018
- Author(s)
  Shidahara M, Thomas BA, Okamura N, Ibaraki M, Matsubara K, Oyama S, Ishikawa Y, Watanuki S, Iwata R, Furumoto S, Tashiro M, Yanai K, Gonda K, Watabe H.
- Journal Title
  
  Ann Nucl Med.
  
  Volume: 59 Issue: 7 Pages: 671-674
- DOI
  10.1007/s12149-017-1185-0
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K20083, KAKENHI-PROJECT-15H04900, KAKENHI-PROJECT-16H05383, KAKENHI-PROJECT-16H05385, KAKENHI-PROJECT-17H04118, KAKENHI-PROJECT-15K08687
[Journal Article] Comparison of 18F-T807 and 18F-THK5117 PET in a Mouse Model of Tau Pathology2018
- Author(s)
  Brendel Matthias、Yousefi Behrooz H.、Blume Tanja、Herz Michael、Focke Carola、Deussing Maximilian、Peters Finn、Lindner Simon、von Ungern-Sternberg Barbara、Drzezga Alexander、Bartenstein Peter、Haass Christian、Okamura Nobuyuki、Herms Jochen、Yakushev Igor、Rominger Axel
- Journal Title
  
  Frontiers in Aging Neuroscience
  
  Volume: 10 Pages: 174-174
- DOI
  10.3389/fnagi.2018.00174
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02771, KAKENHI-PLANNED-26117003
[Journal Article] THK5351-PETから見えてきた分子イメージングの新しい方向性2018
- Author(s)
  岡村信行、原田龍一、江面道典、工藤幸司
- Journal Title
  
  日本認知症学会誌
  
  Volume: 32 Pages: 538-545
- Data Source
  KAKENHI-PROJECT-16K15570
[Journal Article] Neuroimaging-pathological correlations of [(18)F]THK5351 PET in progressive supranuclear palsy2018
- Author(s)
  Ishiki A, Furukawa K, et al.
- Journal Title
  
  Acta Neuropathol Commun
  
  Volume: 6 Issue: 1 Pages: 53-53
- DOI
  10.1186/s40478-018-0556-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09318, KAKENHI-PROJECT-17K20083, KAKENHI-PROJECT-16H05383, KAKENHI-PROJECT-16H05385, KAKENHI-PROJECT-18H02738, KAKENHI-PROJECT-18H02771, KAKENHI-PROJECT-16K15570, KAKENHI-PROJECT-16H06277, KAKENHI-PROJECT-18K15538, KAKENHI-PLANNED-26117003
[Journal Article] Tau PET imaging: current status and future direction2018
- Author(s)
  Okamura N, Harada R, Ishiki A, Kikuchi A, Nakamura T, Kudo Y
- Journal Title
  
  Clin Transl Imaging
  
  Volume: 6 Issue: 4 Pages: 305-316
- DOI
  10.1007/s40336-018-0290-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09789, KAKENHI-PROJECT-18H02771, KAKENHI-PLANNED-26117003
[Journal Article] Quantitative evaluation of tau PET tracers 18F-THK5351 and 18F-AV-1451 in Alzheimer’s disease with standardized uptake value peak-alignment (SUVP) normalization2018
- Author(s)
  Chen Jingyun、Alzheimer’s Disease Neuroimaging Initiative、Li Yi、Pirraglia Elizabeth、Okamura Nobuyuki、Rusinek Henry、de Leon Mony J.
- Journal Title
  
  European Journal of Nuclear Medicine and Molecular Imaging
  
  Volume: 45 Issue: 9 Pages: 1596-1604
- DOI
  10.1007/s00259-018-4040-1
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02771, KAKENHI-PLANNED-26117003
[Journal Article] Correlations of (18)F-THK5351 PET with Postmortem Burden of Tau and Astrogliosis in Alzheimer Disease.2018
- Author(s)
  Harada R, Furukawa K, et al.
- Journal Title
  
  J Nucl Med
  
  Volume: 59 Issue: 4 Pages: 671-674
- DOI
  10.2967/jnumed.117.197426
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09318, KAKENHI-PROJECT-16K15570, KAKENHI-PROJECT-17K20083, KAKENHI-PLANNED-26117003, KAKENHI-PROJECT-26253016, KAKENHI-PROJECT-15H04900, KAKENHI-PROJECT-16H05383, KAKENHI-PROJECT-16H05385, KAKENHI-PROJECT-16H06621, KAKENHI-PROJECT-16H07486, KAKENHI-PROJECT-15K08127
[Journal Article] Dissociation of tau deposits and brain atrophy in early Alzheimer’s disease: A combined positron emission tomography/magnetic resonance imaging study2018
- Author(s)
  Shigemoto Y, Sone D, Imabayashi E, Maikusa N, Okamura N, Furumoto S, Kudo Y, Ogawa M, Takano H, Yokoi Y, Sakata M, Tsukamoto T, Kato K, Sato N, Matsuda H.
- Journal Title
  
  Front in Aging Neurosci
  
  Volume: 10 Pages: 223-223
- DOI
  10.3389/fnagi.2018.00223
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07779, KAKENHI-PROJECT-18H02771, KAKENHI-PLANNED-26117003
[Journal Article] Visualization of ischemic stroke-related changes on 18F-THK-5351 positron emission tomography2018
- Author(s)
  Huang Kuo-Lun、Hsu Jung-Lung、Lin Kun-Ju、Chang Chien-Hung、Wu Yi-Ming、Chang Ting-Yu、Chang Yeu-Jhy、Liu Chi-Hung、Ho Meng-Yang、Wey Shiaw-Pyng、Yen Tzu-Chen、Okamura Nobuyuki、Hsiao Ing-Tsung、Lee Tsong-Hai
- Journal Title
  
  EJNMMI Research
  
  Volume: 8 Issue: 1 Pages: 62-62
- DOI
  10.1186/s13550-018-0417-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02771, KAKENHI-PLANNED-26117003
[Journal Article] S-[18F]THK-5117-PET and [11C]PIB-PET Imaging in Idiopathic Normal Pressure Hydrocephalus in Relation to Confirmed Amyloid-β Plaques and Tau in Brain Biopsies2018
- Author(s)
  Leinonen V, Rauramaa T, Johansson J, Bottelbergs A, Tesseur I, van der Ark P, Pemberton D, Koivisto Anne M., Jskelinen Juha E., Hiltunen M, Herukka Sanna-Kaisa, Blennow K, Zetterberg H, Jokinen P, Rokka J, Helin S, Haaparanta-Solin M, Solin O, Okamura N, Kolb Hartmuth C., Rinne Juha O.
- Journal Title
  
  Journal of Alzheimer's Disease
  
  Volume: 64 Issue: 1 Pages: 171-179
- DOI
  10.3233/jad-180071
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02771, KAKENHI-PLANNED-26117003
[Journal Article] Involvement of the Precuneus/Posterior Cingulate Cortex Is Significant for the Development of Alzheimer’s Disease: A PET (THK5351, PiB) and Resting fMRI Study2018
- Author(s)
  Yokoi Takamasa、Watanabe Hirohisa、Ishigaki Shinsuke、Katsuno Masahisa、Miyao Shinichi、Kato Katsuhiko、Naganawa Shinji、Harada Ryuichi、Okamura Nobuyuki、Yanai Kazuhiko、Yoshida Mari、Sobue Gen （ほか9名）
- Journal Title
  
  Frontiers in Aging Neuroscience
  
  Volume: 10 Pages: 304-304
- DOI
  10.3389/fnagi.2018.00304
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07367, KAKENHI-PROJECT-18K19510, KAKENHI-ORGANIZER-26117001, KAKENHI-PLANNED-26117002, KAKENHI-PLANNED-26117004, KAKENHI-PROJECT-17H04259, KAKENHI-PROJECT-18H02771, KAKENHI-PROJECT-17K16117, KAKENHI-PROJECT-18K15538, KAKENHI-PLANNED-26117003
[Journal Article] IgLON5: A case with predominant cerebellar tau deposits and leptomeningeal inflammation2018
- Author(s)
  Schoberl Florian、Levin Johannes、Remi Jan、Goldschagg Nicolina、Eren Ozan、Okamura Nobuyuki、Unterrainer Marcus、Rominger Axel、Albert Nathalie、Brendel Matthias
- Journal Title
  
  Neurology
  
  Volume: 91 Issue: 4 Pages: 180-182
- DOI
  10.1212/wnl.0000000000005859
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02771, KAKENHI-PLANNED-26117003
[Journal Article] [18F]-THK5351 PET correlates with topology and symptom severity in progressive supranuclear palsy.2018
- Author(s)
  Brendel M, Schoneckerr S, Hoglinger G, Lindner S, Havla J, Blautzik J, Sauerbeck J, Rohrer G, Zach C, Vettermann F, Lang AE, Golbe L, Nubling G, Bartenstein P, Furukawa K, Ishiki A, Botzel K, Danek A, Okamura N, Levin J, Rominger A.
- Journal Title
  
  Front Aging Neurosci.
  
  Volume: 9 Pages: 440-440
- DOI
  10.3389/fnagi.2017.00440
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15570, KAKENHI-PROJECT-15H04900, KAKENHI-PROJECT-16H06621
[Journal Article] Investigation of the quantitative accuracy of low-dose amyloid and tau PET imaging.2018
- Author(s)
  Nai YH, Watanuki S, Tashiro M, Okamura N, Watabe H.
- Journal Title
  
  Radiol Phys Technol.
  
  Volume: 11 Issue: 4 Pages: 451-459
- DOI
  10.1007/s12194-018-0485-y
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K20083, KAKENHI-PROJECT-16H05385, KAKENHI-PROJECT-17H04118, KAKENHI-PROJECT-18H02771, KAKENHI-PLANNED-26117003
[Journal Article] Dual tracer tau PET imaging reveals different molecular targets for 11C-THK5351 and 11C-PBB3 in the Alzheimer brain2018
- Author(s)
  Chiotis Konstantinos、Stenkrona Per、Almkvist Ove、Stepanov Vladimir、Ferreira Daniel、Arakawa Ryosuke、Takano Akihiro、Westman Eric、Varrone Andrea、Okamura Nobuyuki、Shimada Hitoshi、Higuchi Makoto、Halldin Christer、Nordberg Agneta
- Journal Title
  
  European Journal of Nuclear Medicine and Molecular Imaging
  
  Volume: 45 Issue: 9 Pages: 1605-1617
- DOI
  10.1007/s00259-018-4012-5
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05324, KAKENHI-PROJECT-18H02771, KAKENHI-PLANNED-26117003
[Journal Article] Tau imaging with [18F]THK-5351 in progressive supranuclear palsy.2017
- Author(s)
  Ishiki A, Harada R, Okamura N, Tomita N, Rowe CC, Villemagne VL, Yanai K, Kudo Y, Arai H, Furumoto S, Tashiro M, Furukawa K.
- Journal Title
  
  Eur J Neurol.
  
  Volume: 24 Issue: 1 Pages: 130-136
- DOI
  10.1111/ene.13164
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26117003, KAKENHI-PROJECT-15H04900, KAKENHI-PROJECT-15K15268, KAKENHI-PROJECT-15K19767, KAKENHI-PROJECT-17K09318, KAKENHI-PROJECT-16H06621
[Journal Article] 18F-Labeled 2-Arylquinoline Derivatives for Tau Imaging: Chemical, Radiochemical, Biological and Clinical Features.2017
- Author(s)
  Furumoto S, Tago T, Harada R, Kudo Y, Okamura N.
- Journal Title
  
  Curr Alzheimer Res.
  
  Volume: 14 Pages: 178-185
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K15570
[Journal Article] Brain imaging: Applications of tau PET imaging.2017
- Author(s)
  Okamura N, Yanai K.
- Journal Title
  
  Nat Rev Neurol.
  
  Volume: 13 Issue: 4 Pages: 197-198
- DOI
  10.1038/nrneurol.2017.38
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-26117003, KAKENHI-PROJECT-15H04900
[Journal Article] Prediction of the clinical standardized uptake value ratio in amyloid PET imaging using a biomathematical modeling approach towards the efficient development of a radioligand.2017
- Author(s)
  Arakawa Y, Nai Y, Shidahara M, Furumoto S, Seki C, Okamura N, Tashiro M, Kudo Y, Yanai K, Gonda K, Watabe H.
- Journal Title
  
  J Nucl Med.
  
  Volume: - Issue: 8 Pages: 1285-1292
- DOI
  10.2967/jnumed.116.183566
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26117003, KAKENHI-PROJECT-26293133, KAKENHI-PROJECT-15K08687, KAKENHI-PROJECT-15H04900
[Journal Article] Regional tau deposition and subregion atrophy of medial temporal structures in early Alzheimer's disease: A combined positron emission tomography/magnetic resonance imaging study2017
- Author(s)
  Sone Daichi、Imabayashi Etsuko、Maikusa Norihide、Okamura Nobuyuki、Furumoto Shozo、Kudo Yukitsuka、Ogawa Masayo、Takano Harumasa、Yokoi Yuma、Sakata Masuhiro、Tsukamoto Tadashi、Kato Koichi、Matsuda Hiroshi
- Journal Title
  
  Alzheimers Dement (Amst)
  
  Volume: 9 Issue: 1 Pages: 35-40
- DOI
  10.1016/j.dadm.2017.07.001
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-26117003, KAKENHI-PROJECT-15H04900
[Journal Article] Monoamine oxidase B inhibitor, selegiline, reduces 18F-THK5351 uptake in the human brain.2017
- Author(s)
  Ng KP, Pascoal TA, Mathotaarachchi S, Therriault J, Kang MS, Shin M, Guiot MC, Guo Q, Harada R, Comley RA, Massarweh G, Soucy JP, Okamura N, Gauthier S, Rosa-Neto P.
- Journal Title
  
  Alzheimers Res Ther.
  
  Volume: 9:25 Issue: 1 Pages: 25-25
- DOI
  10.1186/s13195-017-0253-y
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26117003, KAKENHI-PROJECT-15H04900, KAKENHI-PROJECT-15K19767
[Journal Article] Histamine N-methyltransferase regulates aggression and the sleep-wake cycle2017
- Author(s)
  Naganuma Fumito、Nakamura Tadaho、Yoshikawa Takeo、Iida Tomomitsu、Miura Yamato、Karpati Aniko、Matsuzawa Takuro、Yanai Atushi、Mogi Asuka、Mochizuki Takatoshi、Okamura Nobuyuki、Yanai Kazuhiko
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1 Pages: 15899-15899
- DOI
  10.1038/s41598-017-16019-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K16753, KAKENHI-PROJECT-26253016, KAKENHI-PROJECT-15H04900, KAKENHI-PROJECT-16K18389
[Journal Article] CSF clearance in Alzheimer Disease measured with dynamic PET.2017
- Author(s)
  de Leon MJ, Li Y, Okamura N, Tsui WH, Saint Louis LA, Glodzik L, Osorio RS, Fortea J, Butler T, Pirraglia E, Fossati S, Kim HJ, Carare RO, Nedergaard M, Benveniste H, Rusinek H.
- Journal Title
  
  J Nucl Med.
  
  Volume: - Issue: 9 Pages: 1471-1476
- DOI
  10.2967/jnumed.116.187211
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26117003, KAKENHI-PROJECT-15H04900
[Journal Article] A report of the automated radiosynthesis of the tau PET radiopharmaceutical, [18F]-THK-5351.2017
- Author(s)
  Neelamegam R, Yokell DL, Rice PA, Furumoto S, Kudo Y, Okamura N, El Fakhri G.
- Journal Title
  
  J Labelled Comp Radiopharm.
  
  Volume: 60 Issue: 2 Pages: 140-146
- DOI
  10.1002/jlcr.3482
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26117003, KAKENHI-PROJECT-15H04900
[Journal Article] Tau positron emission tomography using [18F]THK5351 and cerebral glucose hypometabolism in Alzheimer's disease2017
- Author(s)
  Kang JM, Lee SY, Seo S, Jeong HJ, Woo SH, Lee H, Lee YB, Yeon BK, Shin DH, Park KH, Kang H, Okamura N, Furumoto S, Yanai K, Villemagne VL, Seong JK, Na DL, Ido T, Cho J, Lee KM, Noh Y
- Journal Title
  
  Neurobiology of Aging
  
  Volume: 59 Issue: 1 Pages: 210-219
- DOI
  10.1097/wad.0000000000000216
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26117003, KAKENHI-PROJECT-15H04900
[Journal Article] アルツハイマー病理を標的とした分子イメージングプローブの開発2017
- Author(s)
  岡村信行、原田龍一、古本祥三、中村正帆、谷内一彦，工藤幸司
- Journal Title
  
  日本薬理学雑誌
  
  Volume: 150 Pages: 172-176
- NAID
  130006107929
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K15570
[Journal Article] Tau positron emission tomography using [18F]THK5351 and cerebral glucose hypometabolism in Alzheimer's disease.2017
- Author(s)
  Kang JM, Lee SY, Seo S, Jeong HJ, Woo SH, Lee H, Lee YB, Yeon BK, Shin DH, Park KH, Kang H, Okamura N, Furumoto S, Yanai K, Villemagne VL, Seong JK, Na DL, Ido T, Cho J, Lee KM, Noh Y.
- Journal Title
  
  Neurobiol Aging.
  
  Volume: 59 Pages: 210-219
- DOI
  10.1016/j.neurobiolaging.2017.08.008
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04900
[Journal Article] Biodistribution and radiation dosimetry for the tau tracer 18F-THK-5351 in healthy human subjects.2017
- Author(s)
  Hsiao IT, Lin KJ, Huang KL, Huang CC, Chen HS, Wey SP, Yen TC, Okamura N, Hsu JL.
- Journal Title
  
  J Nucl Med.
  
  Volume: - Issue: 9 Pages: 1498-1503
- DOI
  10.2967/jnumed.116.189126
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26117003, KAKENHI-PROJECT-15H04900
[Journal Article] 18F-Labeled 2-Arylquinoline Derivatives for Tau Imaging: Chemical, Radiochemical, Biological and Clinical Features.2017
- Author(s)
  Furumoto S, Tago T, Harada R, Kudo Y, Okamura N.
- Journal Title
  
  Curr Alzheimer Res.
  
  Volume: 14 Pages: 178-185
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04900
[Journal Article] In vivo comparison of tau radioligands 18F-THK-5351 and 18F-THK-5317.2017
- Author(s)
  Betthauser T, Lao PJ, Murali D, Barnhart TE, Furumoto S, Okamura N, Stone CK, Johnson SC, Christian BT.
- Journal Title
  
  J Nucl Med.
  
  Volume: - Issue: 6 Pages: 996-1002
- DOI
  10.2967/jnumed.116.182980
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26117003, KAKENHI-PROJECT-15H04900
[Journal Article] Characterization of the radiosynthesis and purification of [ 18 F]THK-5351, a PET ligand for neurofibrillary tau2017
- Author(s)
  Betthauser Tobey J.、Ellison Paul A.、Murali Dhanabalan、Lao Patrick J.、Barnhart Todd E.、Furumoto Shozo、Okamura Nobuyuki、Johnson Sterling C.、Engle Jonathan W.、Nickles Robert J.、Christian Bradley T.
- Journal Title
  
  Applied Radiation and Isotopes
  
  Volume: 130 Pages: 230-237
- DOI
  10.1016/j.apradiso.2017.10.002
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26117003, KAKENHI-PROJECT-15H04900
[Journal Article] Comparative binding properties of the tau PET tracers THK5117, THK5351, PBB3, and T807 in postmortem Alzheimer brains.2017
- Author(s)
  Lemoine L, Gillberg PG, Svedberg M, Stepanov V, Jia Z, Huang J, Nag S, Tian H, Ghetti B, Okamura N, Higuchi M, Halldin C, Nordberg A.
- Journal Title
  
  Alzheimers Res Ther.
  
  Volume: 9 Issue: 1 Pages: 96-96
- DOI
  10.1186/s13195-017-0325-z
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15570, KAKENHI-PLANNED-26117003, KAKENHI-PROJECT-15H04900
[Journal Article] Characteristics of Tau and Its Ligands in PET Imaging2016
- Author(s)
  Ryuichi Harada, Nobuyuki Okamura, Shozo Furumoto, Tetsuro Tago, Kazuhiko Yanai, Hiroyuki Arai, Yukitsuka Kudo
- Journal Title
  
  Biomolecules
  
  Volume: 6 Issue: 1 Pages: 1-15
- DOI
  10.3390/biom6010007
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K19767, KAKENHI-PLANNED-26117003, KAKENHI-PROJECT-15H04900, KAKENHI-PROJECT-14J06908
[Journal Article] In vivo visualization of tau pathology using 18F-THK5351 PET in corticobasal syndrome.2016
- Author(s)
  Kikuchi A, Okamura N, Hasegawa T, Harada R, Watanuki S, Funaki Y, Kobayashi M, Tano O, Baba T, Sugeno N, Oshima R, Yoshida S, Kobayashi J, Ezura M, Hiraoka K, Mugikura S, Takase K, Iwata R, Taki Y, Furukawa K, HArai H, Furumoto S, Tashiro M, Yanai K, Kudo Y, Takeda A，Aoki M.
- Journal Title
  
  Neurology
  
  Volume: 87 Issue: 22 Pages: 2309-2316
- DOI
  10.1212/wnl.0000000000003375
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-15H01550, KAKENHI-PLANNED-26117003, KAKENHI-PROJECT-15H04900, KAKENHI-PROJECT-26461263, KAKENHI-PROJECT-15K19767, KAKENHI-PROJECT-26461303, KAKENHI-PROJECT-16K15570
[Journal Article] Applied multimodal diagnostics in a case of presenile dementia.2016
- Author(s)
  Schonecker S, Brendel M, Huber M, Vollmar C, Huppertz HJ, Teipel S, Okamura N, Levin J, Rominger A, Danek A.
- Journal Title
  
  BMC Neurol.
  
  Volume: 16 Issue: 1 Pages: 131-131
- DOI
  10.1186/s12883-016-0647-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26117003, KAKENHI-PROJECT-15H04900
[Journal Article] microPET Imaging of Tau Pathology with [18F]-THK5117 in two Transgenic Mouse Models.2016
- Author(s)
  Brendel M, Jaworska A, Probst F, Overhoff F, Korzhova V, Lindner S, Carlsen J, Bartenstein P, Harada R, Kudo Y, Haass C, van Leuven F, Okamura N, Herms J, Rominger A.
- Journal Title
  
  J Nucl Med
  
  Volume: 印刷中 Issue: 5 Pages: 792-798
- DOI
  10.2967/jnumed.115.163493
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04900, KAKENHI-PROJECT-14J06908, KAKENHI-PROJECT-16K15570
[Journal Article] Advances in the development of tau PET radiotracers and their clinical applications.2016
- Author(s)
  Okamura N, Harada R, Furukawa K, Furumoto S, Tago T, Yanai K, Arai H, Kudo Y.
- Journal Title
  
  Ageing Res Rev.
  
  Volume: - Pages: 107-113
- DOI
  10.1016/j.arr.2015.12.010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K15268, KAKENHI-PROJECT-15K19767, KAKENHI-PLANNED-26117003, KAKENHI-PROJECT-14J06908, KAKENHI-PROJECT-15H04900, KAKENHI-PROJECT-16K15570
[Journal Article] Tau imaging in the study of ageing, Alzheimer's disease, and other neurodegenerative conditions.2016
- Author(s)
  Villemagne VL, Okamura N.
- Journal Title
  
  Current Opinion in Neurology
  
  Volume: 36 Pages: 43-51
- DOI
  10.1016/j.conb.2015.09.002
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26117003, KAKENHI-PROJECT-15H04900
[Journal Article] Introduction and overview of the special issue "Brain imaging and aging": The new era of neuroimaging in aging research.2016
- Author(s)
  Furukawa K, Ishiki A, Tomita N, Onaka Y, Saito H, Nakamichi T, Hara K, Kusano Y, Ebara M, Arata Y, Sakota M, Miyazawa I, Totsune T, Okinaga S, Okamura N, Kudo Y, Arai H.
- Journal Title
  
  Ageing Res Rev
  
  Volume: - Pages: 1-3
- DOI
  10.1016/j.arr.2016.02.005
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K15268, KAKENHI-PLANNED-26117003, KAKENHI-PROJECT-15H04900, KAKENHI-PROJECT-16K15570
[Journal Article] Structure-Activity Relationship of 2-Arylquinolines as PET Imaging Tracers for Tau Pathology in Alzheimer’s Disease2016
- Author(s)
  Tetsuro Tago, Shozo Furumoto, Nobuyuki Okamura, Ryuichi Harada, Hajime Adachi, Yoichi Ishikawa, Kazuhiko Yanai, Ren Iwata, and Yukitsuka Kudo
- Journal Title
  
  Journal of Nuclear Medicine
  
  Volume: 57(4) Issue: 4 Pages: 608-614
- DOI
  10.2967/jnumed.115.166652
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K19767, KAKENHI-PLANNED-26117003, KAKENHI-PROJECT-14J06908, KAKENHI-PROJECT-25293259, KAKENHI-PROJECT-15H04900, KAKENHI-PROJECT-16H05383, KAKENHI-PROJECT-16K15570
[Journal Article] Development of [11C]/[3H]THK-5351 - A potential novel carbon-11 tau imaging PET radioligand.2016
- Author(s)
  Stepanov V, Svedberg M, Jia Z, Krasikova R, Lemoine L, Okamura N, Furumoto S, Mitsios N, Mulder J, Langstrom B, Nordberg A, Halldin C.
- Journal Title
  
  Nucl Med Biol.
  
  Volume: 46 Pages: 50-53
- DOI
  10.1016/j.nucmedbio.2016.12.004
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26117003, KAKENHI-PROJECT-15H04900
[Journal Article] Dynamic PET measures of tau accumulation in cognitively normal older adults and Alzheimer's disease patients measured using [18F]THK-5351.2016
- Author(s)
  Lockhart SN, Baker SL, Okamura N, Furukawa K, Ishiki A, Furumoto S, Tashiro M, Yanai K, Arai H, Kudo Y, Harada R, Tomita N, Hiraoka K, Watanuki S, Jagust WJ.
- Journal Title
  
  PLoS One.
  
  Volume: 11 Issue: 6 Pages: e0158460-e0158460
- DOI
  10.1371/journal.pone.0158460
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26117003, KAKENHI-PROJECT-15H04900, KAKENHI-PROJECT-15K08127, KAKENHI-PROJECT-16K15570
[Journal Article] Untangling tau imaging.2016
- Author(s)
  Villemagne VL, Okamura N, Rowe CC.
- Journal Title
  
  Alzheimers Dement (Amst)
  
  Volume: 4 Issue: 1 Pages: 39-42
- DOI
  10.1016/j.dadm.2016.05.001
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26117003, KAKENHI-PROJECT-15H04900, KAKENHI-PROJECT-16K15570
[Journal Article] 18F-THK5351: A Novel PET Radiotracer for Imaging Neurofibrillary Pathology in Alzheimer Disease2016
- Author(s)
  Harada R, Okamura N, Furumoto S, Furukawa K, Ishiki A, Tomita N, Tago T, Hiraoka K, Watanuki S, Shidahara M, Miyake M, Ishikawa Y, Matsuda R, Inami A, Yoshikawa T, Funaki Y, Iwata R, Tashiro M, Yanai K, Arai H, Kudo Y
- Journal Title
  
  J Nucl Med
  
  Volume: 57 Issue: 2 Pages: 208-214
- DOI
  10.2967/jnumed.115.164848
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08127, KAKENHI-PROJECT-15K15268, KAKENHI-PROJECT-15K19767, KAKENHI-PLANNED-26117003, KAKENHI-PROJECT-26253016, KAKENHI-PROJECT-15H04900, KAKENHI-PROJECT-14J06908, KAKENHI-PROJECT-25670525, KAKENHI-PROJECT-26830041, KAKENHI-PROJECT-25293259, KAKENHI-PROJECT-16H05383
[Journal Article] Characterization of the radiolabeled metabolite of tau PET tracer 18F-THK5351.2016
- Author(s)
  Harada R, Furumoto S, Tago T, Furukawa K, Ishiki A, Tomita N, Iwata R, Tashiro M, Arai H, Yanai K, Kudo Y, Okamura N.
- Journal Title
  
  Eur J Nucl Med Mol Imaging.
  
  Volume: 43 Issue: 12 Pages: 2211-2218
- DOI
  10.1007/s00259-016-3453-y
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-26117003, KAKENHI-PROJECT-15H04900, KAKENHI-PROJECT-15K19767, KAKENHI-PROJECT-16K15570
[Journal Article] Preclinical evaluation of [18F]THK-5015 enantiomers: effects of chirality on its effectiveness as a tau imaging radiotracer.2015
- Author(s)
  Tago T., Furumoto S., Okamura N., Harada R., Adachi H., Ishikawa Y., Yanai K., Iwata R., Kudo Y.
- Journal Title
  
  Mol. Imaging Biol.
  
  Volume: 未定 Issue: 2 Pages: 258-266
- DOI
  10.1007/s11307-015-0879-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K15444, KAKENHI-PROJECT-15K19767, KAKENHI-PLANNED-26117003, KAKENHI-PROJECT-14J06908, KAKENHI-PROJECT-25293257, KAKENHI-PROJECT-25293259, KAKENHI-PROJECT-15H04900
[Journal Article] Visualization of regional tau deposits using 3H-THK5117 in Alzheimer brain tissue2015
- Author(s)
  Lemoine L, Saint-Aubert L, Marutle A, Antoni G, Eriksson JP, Ghetti B, Okamura N, Nennesmo I, Gillberg PG, Nordberg A
- Journal Title
  
  Acta Neuropathologica Communications
  
  Volume: 3 Issue: 1 Pages: 40-40
- DOI
  10.1186/s40478-015-0220-4
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26117003, KAKENHI-PROJECT-15H04900
[Journal Article] Longitudinal Assessment of Tau Pathology in Patients with Alzheimer's Disease Using [18F]THK-5117 Positron Emission Tomography2015
- Author(s)
  Ishiki, Aiko Okamura, Nobuyuki Furukawa, Katsutoshi Furumoto, Shozo Harada, Ryuichi Tomita, Naoki Hiraoka, Kotaro Watanuki, Shoichi Ishikawa, Yoichi Tago, Tetsuro Funaki, Yoshihito Iwata, Ren Tashiro, Manabu Yanai, Kazuhiko Kudo, Yukitsuka Arai, Hiroyuki
- Journal Title
  
  PLoS One
  
  Volume: 10 Issue: 10 Pages: 1-9
- DOI
  10.1371/journal.pone.0140311
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08127, KAKENHI-PROJECT-15K15268, KAKENHI-PLANNED-26117003, KAKENHI-PROJECT-15H04900, KAKENHI-PROJECT-14J06908, KAKENHI-PROJECT-25670525
[Journal Article] Non-invasive assessment of Alzheimer's disease neurofibrillary pathology using ^<18>F-THK5105 PET2014
- Author(s)
 Nobuyuki Okamura, Shozo Furumoto, Michelle T. Fodero-Tavoletti, Rachel S. Mulligan, Ryuichi Harada, Paul Yates, Svetlana Pejoska, Yukitsuka Kudo, Colin L. Masters, Kazuhiko Yanai, Christopher C. Rowe, Victor L. Villemagne
- Journal Title
 
 Brain
 
 Volume: 137 Issue: 6 Pages: 1762-1771
- DOI
 10.1093/brain/awu064
- Peer Reviewed / Open Access
- Data Source
 KAKENHI-PROJECT-12J07785, KAKENHI-PROJECT-25670524, KAKENHI-PLANNED-26117003, KAKENHI-PROJECT-26253016
[Journal Article] Non-invasive assessment of Alzheimer's disease neurofibrillary pathology using 18F-THK5105 PET.2014
- Author(s)
  Nobuyuki Okamura, Shozo Furumoto, Michelle T. Fodero-Tavoletti, Rachel S. Mulligan, Ryuichi Harada, Paul Yates, Svetlana Pejoska, Yukitsuka Kudo, Colin L. Masters, Kazuhiko Yanai, Christopher C. Rowe, Victor L. Villemagne
- Journal Title
  
  Brain
  
  Volume: 137 Pages: 1762-1771
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25293259
[Journal Article] Pitfalls of voxel-based amyloid PET analyses for diagnosis of Alzheimer's disease: artifacts due to non-specific uptake in the white matter and the skull.2014
- Author(s)
  Arai A, Kaneta T, Okamura N, Tashiro M, Iwata R, Takanami K, Fukuda H, Takahashi S, Yanai K, Kudo Y, Arai H.
- Journal Title
  
  Tohoku J Exp Med
  
  Volume: 234 Pages: 175-181
- NAID
  130004694506
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591745
[Journal Article] Synthesis and preliminary evaluation of 2-arylhydroxyquinoline derivatives for tau imaging2014
- Author(s)
  Tetsuro Tago, Shozo Furumoto, Nobuyuki Okamura, Ryuichi Harada, Yoichi Ishikawa, Hiroyuki Arai, Kazuhiko Yanai, Ren Iwata, Yhkitsuka Kudo
- Journal Title
  
  Journal of Labelled Compounds and Radiopharmaceuticals
  
  Volume: 57 Issue: 1 Pages: 18-24
- DOI
  10.1002/jlcr.3133
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J07785, KAKENHI-PROJECT-23390297, KAKENHI-PROJECT-24659255, KAKENHI-PROJECT-25293257, KAKENHI-PROJECT-25461870, KAKENHI-PROJECT-25670523, KAKENHI-PROJECT-25670524
[Journal Article] [18F]THK-5117 PET for assessing neurofibrillary pathology in Alzheimer's disease.2014
- Author(s)
  Harada R, Furukawa K, et al.
- Journal Title
  
  Eur J Nucl Med Mol Imaging
  
  Volume: 42 Issue: 7 Pages: 1052-1061
- DOI
  10.1007/s00259-015-3035-4
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24390179, KAKENHI-PROJECT-15K15268, KAKENHI-PROJECT-15K15444, KAKENHI-PLANNED-26117003, KAKENHI-PROJECT-26253016, KAKENHI-PROJECT-15H04900, KAKENHI-PROJECT-25670525, KAKENHI-PROJECT-26830041, KAKENHI-PROJECT-25293257
[Journal Article] Non-invasive assessment of Alzheimer's disease neurofibrillary pathology using 18F-THK5105 PET.2014
- Author(s)
  Okamura N, Furumoto S, Fodero-Tavoletti MT, Mulligan RS, Harada R, Yates P, Pejoska S, Kudo Y, Masters CL, Yanai K, Rowe CC, Villemagne VL.
- Journal Title
  
  Brain
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293259
[Journal Article] Analysis of early phase [^(11)C]BF-227 PET , and its application for anatomical standardization of late-phase images for 3D-SSP analysis2014
- Author(s)
  Kaneta T, Okamura N, Arai A, Takanami K, Furukawa K, Tashiro M, Furumoto S, Iwata R, Takahashi S, Arai H, Y anai K, Kudo Y
- Journal Title
  
  Jpn J Radiol
  
  Volume: 32 Issue: 3 Pages: 138-144
- DOI
  10.1007/s11604-013-0276-7
- NAID
  50009030775
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23390297, KAKENHI-PROJECT-24390179, KAKENHI-PROJECT-24591745, KAKENHI-PROJECT-24659255, KAKENHI-PROJECT-25670524, KAKENHI-PROJECT-25670525, KAKENHI-PROJECT-26253016
[Journal Article] In vivo evaluation of a novel tau imaging tracer for Alzheimer's disease2014
- Author(s)
  Villemagne L. Victor, Shozo Furumoto, Michelle T. Fodero-Tavoletti, Rachel S. Mulligan, John Hodges, Ryuichi Harada, Paul Yates, Oliver Piguet, Svetlana Pejoska, Vincent Doré, Kazuhiko Yanai, Colin L. Masters, Yukitsuka Kudo, Christopher C. Rowe, Nobuyuki Okamura.
- Journal Title
  
  European Journal of Nuclear Medicine and Molecular Imaging
  
  Volume: 41 Issue: 5 Pages: 816-826
- DOI
  10.1007/s00259-013-2681-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-12J07785, KAKENHI-PROJECT-23390297, KAKENHI-PROJECT-24659255, KAKENHI-PROJECT-25293259, KAKENHI-PROJECT-25670524, KAKENHI-PLANNED-26117003, KAKENHI-PROJECT-26253016
[Journal Article] Imaging of amyloid deposition in human brain using positron emission tomography and [18F]FACT: comparison with [11C]PIB.2014
- Author(s)
  Ito H, Shinotoh H, Shimada H, Miyoshi M, Yanai K, Okamura N, Takano H, Takahashi H, Arakawa R, Kodaka F, Ono M, Eguchi Y, Higuchi M, Fukumura T, Suhara T.
- Journal Title
  
  European Journal of Nuclear Medicine and Molecular Imaging
  
  Volume: 41
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390297
[Journal Article] Assessing THK523 selectivity for tau deposits in Alzheimer's disease and non Alzheimer's disease tauopathies.2014
- Author(s)
  Fodero-Tavoletti MT, Furumoto S, Taylor L, McLean CA, Mulligan RS, Birchall I, Harada R, Masters CL, Yanai K, Kudo Y, Rowe CC, Okamura N, Villemagne VL.
- Journal Title
  
  Alzheimer's Research & Therapy
  
  Volume: 6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390297
[Journal Article] Assessing THK523 selectivity for tau deposits in Alzheimer's disease and non-Alzheimer's disease tauopathies2014
- Author(s)
  Fodero-Tavoletti MT, Furumoto S, Taylor L, McLean CA, Mulligan RS, Birchall I, Harada R, Masters CL, Y anai K, Kudo Y, Rowe CC, Okamura N, Villemagne VL
- Journal Title
  
  Alzheimers Res Ther
  
  Volume: 6 Pages: 11-11
- URL
  http://alzres.com/content/6/1/11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390297
[Journal Article] Non-invasive assessment of Alzheimer's disease neurofibrillary pathology using 18F-THK5105 PET.2014
- Author(s)
  Okamura N, Furumoto S, Fodero-Tavoletti MT, Mulligan RS, Harada R, Yates P, Pejoska S, Kudo Y, Masters CL, Yanai K, Rowe CC, Villemagne VL.
- Journal Title
  
  Brain
  
  Volume: 137
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390297
[Journal Article] Use of a benzimidazole derivative BF-188 in fluorescence multispectral imaging for selective visualization of tau protein fibrils in the Alzheimer's disease brain2014
- Author(s)
  Ryuichi Harada, Nobuyuki Okamura, Shozo Furumoto, Takeo Yoshikawa, Hiroyuki Arai, Kazuhiko Yanai, Yukitsuka Kudo.
- Journal Title
  
  Molecular Imaging and Biology
  
  Volume: 16 Issue: 1 Pages: 19-27
- DOI
  10.1007/s11307-013-0667-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J07785, KAKENHI-PROJECT-23390297, KAKENHI-PROJECT-25670524
[Journal Article] Tau PET imaging in Alzheimer’s disease2014
- Author(s)
  Nobuyuki Okamura, Ryuichi Harada, Shozo Furumoto, Hiroyuki Arai, Kazuhiko Yanai, Yukistsuka Kudo,
- Journal Title
  
  Current Neurology and Neuroscience Reports
  
  Volume: 14 Issue: 11 Pages: 500-500
- DOI
  10.1007/s11910-014-0500-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-14J06908, KAKENHI-PROJECT-25670524, KAKENHI-PLANNED-26117003, KAKENHI-PROJECT-26253016
[Journal Article] タウプローブ開発の最先端2014
- Author(s)
  古本祥三, 岡村信行, 原田龍一, 多胡哲朗, 工藤幸司
- Journal Title
  
  JSMI Report
  
  Volume: 8 Pages: 3-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293259
[Journal Article] Evaluation of the biodistribution and radiation dosimetry of the ^(11)F-labelled amyloid imaging probe [^(18)F]F ACT in humans2013
- Author(s)
  Shidahara M, Tashiro M, Okamura N, Furumoto S, Furukawa K, Watanuki S, Hiraoka K, Miyake M, Iwata R, Tamura H, Arai H, Kudo Y, Y anai K
- Journal Title
  
  EJNMMI Res
  
  Volume: 3 Issue: 1 Pages: 32-32
- DOI
  10.1186/2191-219x-3-32
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390297, KAKENHI-PROJECT-24659255, KAKENHI-PROJECT-25293257, KAKENHI-PROJECT-25670525, KAKENHI-PROJECT-25861059
[Journal Article] Novel ^(11)F-labeled arylquinoline derivatives for non-invasive imaging of tau pathology in Alzheimer' s disease2013
- Author(s)
  Okamura N, Furumoto S, Harada R, Tago T, Y oshikawa T, Fodero-Tavoletti M, Mulligan RS, Villemagne VL, Akatsu H, Y amamoto T, Arai H, Iwata R, Y anai K, Kudo Y
- Journal Title
  
  J Nucl Med
  
  Volume: 54 Issue: 8 Pages: 1420-1427
- DOI
  10.2967/jnumed.112.117341
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390297, KAKENHI-PROJECT-24659255, KAKENHI-PROJECT-25670524
[Journal Article] A ^<18>F-Labeled BF-227 derivative as a potential radioligand for imaging dense amyloid plaques by positron emission tomography2013
- Author(s)
 Shozo Furumoto
- Journal Title
 
 Molecular Imaging and Biology
 
 Volume: 15 Issue: 4 Pages: 497-506
- DOI
 10.1007/s11307-012-0608-5
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-12J07785, KAKENHI-PROJECT-23390297, KAKENHI-PROJECT-24659255, KAKENHI-PROJECT-25293257, KAKENHI-PROJECT-25461870, KAKENHI-PROJECT-25670523, KAKENHI-PROJECT-25670524, KAKENHI-PROJECT-25670525
[Journal Article] Brain accumulation of amyloid β protein visualized by positron emission tomography and BF-227 in Alzheimer's disease patients with or without diabetes mellitus2013
- Author(s)
  Tomita N, Furukawa K, Okamura N, Tashiro M, Une K, Furumoto S, Iwata R, Y anai K, Kudo Y, Arai H
- Journal Title
  
  Geriatr Gerontol Int
  
  Volume: 13 Issue: 1 Pages: 215-221
- DOI
  10.1111/j.1447-0594.2012.00880.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390297, KAKENHI-PROJECT-24659255
[Journal Article] Novel 18F-labeled arylquinoline derivatives for non-invasive imaging of tau pathology in Alzheimer’s disease.2013
- Author(s)
  Okamura et al.
- Journal Title
  
  J Nucl Med
  
  Volume: 54
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390297
[Journal Article] Imaging of tau pathology in a tauopathy mouse model and in Alzheimer patients compared to normal controls2013
- Author(s)
  Maruyama M, Shimada H, Suhara T, Shinotoh H, Ji B, Maeda J, Zhang MR, Trojanowski JQ, Lee VM, Ono M, Masamoto K, Takano H, Sahara N, Iwata N, Okamura N, Furumoto S, Kudo Y, Chang Q, Saido TC, Takashima A, Lewis J, Jang MK, Aoki I, Ito H, Higuchi M.
- Journal Title
  
  Neuron
  
  Volume: 79 Issue: 6 Pages: 1094-1108
- DOI
  10.1016/j.neuron.2013.07.037
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-23111009, KAKENHI-PROJECT-23390235, KAKENHI-PROJECT-23390297, KAKENHI-PROJECT-23591735, KAKENHI-PUBLICLY-24111562, KAKENHI-PROJECT-25670524
[Journal Article] Comparison of the binding Comparison of the binding2013
- Author(s)
  Harada R, Okamura N, Furumoto S, Tago T, Maruyama M, Higuchi M, Y oshikawa T, Arai H, Iwata R, Kudo Y, Y anai K
- Journal Title
  
  Eur J Nucl Med Mol Imaging
  
  Volume: 40 Pages: 125-132
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390297
[Journal Article] Synthesis of [^(11)C]interleukin 8 using a cell-free translation system and l-[^(11)C]methionine2012
- Author(s)
  Harada R, Furumoto S, Y oshikawa T, Ishikawa Y, Shibuya K, Okamura N, Iwata R, Y anai K
- Journal Title
  
  Nucl Med Biol
  
  Volume: 39 Issue: 1 Pages: 155-160
- DOI
  10.1016/j.nucmedbio.2011.07.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390297, KAKENHI-PROJECT-23650610, KAKENHI-PROJECT-23791387, KAKENHI-PROJECT-24659255
[Journal Article] Cholinergic deficit and response to donepezil therapy in Parkinson's disease with dementia2012
- Author(s)
  Hiraoka K, Okamura N, Funaki Y, Hayashi A, Tashiro M, Hisanaga K, Fujii T, Takeda A, Y anai K, Iwata R, Mori E
- Journal Title
  
  Eur Neurol
  
  Volume: 68 Issue: 3 Pages: 137-143
- DOI
  10.1159/000338774
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390297, KAKENHI-PROJECT-23791388, KAKENHI-PROJECT-24300102, KAKENHI-PROJECT-24390219, KAKENHI-PROJECT-24390278, KAKENHI-PROJECT-24659423, KAKENHI-PLANNED-21120007, KAKENHI-PUBLICLY-24111502
[Journal Article] Rowe CC. Differential Diagnosis in Alzheimer's Disease and Dementia with Lewy Bodies via VMAT2 and Amyloid Imaging2012
- Author(s)
  Villemagne VL, Okamura N, Pejoska S, Drago J, Mulligan RS, Chételat G, O'Keefe G, Jones G, Kung HF, Pontecorvo M, Masters CL, Skovronsky DM
- Journal Title
  
  Neurodegener Dis
  
  Volume: 10 Issue: 1-4 Pages: 161-165
- DOI
  10.1159/000334535
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390297
[Journal Article] Cardiac positron-emission tomography images with an amyloid-specific tracer in familial transthyretin-related systemic amyloidosis2012
- Author(s)
  Furukawa K, Ikeda S, Okamura N, Tashiro M, T omita N, Furumoto S, Iwata R, Y anai K, Kudo Y, Arai H
- Journal Title
  
  Circulation
  
  Volume: 125 Issue: 3 Pages: 556-557
- DOI
  10.1161/circulationaha.111.045237
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390297, KAKENHI-PROJECT-24659255
[Journal Article] The challenges of tau imaging2012
- Author(s)
  Villemagne L. Victor
- Journal Title
  
  Future Neurology
  
  Volume: 7 Issue: 4 Pages: 409-421
- DOI
  10.2217/fnl.12.34
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J07785, KAKENHI-PROJECT-23390297
[Journal Article] Greater responsiveness to donepezil in Alzheimer patients with higher levels of acetylcholinesterase based on attention task scores and a donepezil PET study2012
- Author(s)
  Kasuya M, Meguro K, Okamura N, Funaki Y, Ishikawa H, Tanaka N, Iwata R, Y anai K
- Journal Title
  
  Alzheimer Dis Assoc Disord
  
  Volume: 26 Issue: 2 Pages: 113-118
- DOI
  10.1097/wad.0b013e3182222bc0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390297
[Journal Article] Brain histamine H1 receptor occupancy of loratadine measured by PET : Comparison of H1 receptor occupancy and proportional impairment ratio2011
- Author(s)
  Kubo N, Senda M, Ohsumi Y, Sakamoto S, Matsumoto K, Tashiro M, Okamura N, Yanai K
- Journal Title
  
  Hum Psychopharmacol
  
  Volume: 26(2) Pages: 133-139
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390171
[Journal Article] A modified method of 3D-SSP analysis for amyloid PET imaging using [^<11>C]BF-2272011
- Author(s)
 Kaneta T, Okamuia N, Minoshima S, Furukawa K, Tashiro M, Furumoto S, Iwata R, Fukuda H, Takahashi S, Yanai K, Kudo Y, Arai H
- Journal Title
 
 Ann Nucl Med.
 
 Volume: 25 Issue: 10 Pages: 643-649
- DOI
 10.1007/s12149-011-0518-7
- NAID
 10030233510
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-21590754, KAKENHI-PROJECT-22390228, KAKENHI-PROJECT-23390297
[Journal Article] Greater responsiveness to donepezil in Alzheimer patients with higher levels of acetylcholinesterase based on attention task scores and a donepezil PET study2011
- Author(s)
  Masashi Kasuya, Kenichi Meguro, Nobuyuki Okamura, Yoshihito Funaki, Hiroyasu Ishikawa, Naofumi Tanaka, Ren Iwata, Kazuhiko Yanai
- Journal Title
  
  Alzheimer Disease & Associated Disorders
  
  Volume: Jun 9(Epub)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591543
[Journal Article] Positron emission tomography evaluation of sedative properties of antihistamines2011
- Author(s)
  Yanai K, Zhang D, Tashiro M, Yoshikawa T, Naganuma F, Harada R, Nakamura T, Shibuya K, Okamura N
- Journal Title
  
  Expert Opinion on Drug Safety
  
  Volume: 10(4) Pages: 613-613
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390171
[Journal Article] [^<18>F]-THK523, a novel in vivo tau imaging ligand for Alzheimer ' s disease2011
- Author(s)
 Fodero-Tavoletti MT, Okamura N, Furumoto S, Mulligan RS, Connor A, McLean CA, Cao D, Rigopoulos A, O'Keefe G, Gong S, Adlard P A, Barnham KJ, Rowe CC, Masters CL, Kudo Y, Cappai R, Y anai K, Villemagne VL
- Journal Title
 
 Brain
 
 Volume: 134 Issue: 4 Pages: 1089-1100
- DOI
 10.1093/brain/awr038
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-23390297
[Journal Article] In vivo detection of amyloid plaques in the mouse brain using the near-infrared fluorescence probe THK-265.2011
- Author(s)
  Okamura N, et al.
- Journal Title
  
  J Alzheimers Dis
  
  Volume: 23 Pages: 37-48
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591432
[Journal Article] In vivo assessment of vesicular monoamine transporter type 2 in dementia with Lewy bodies and Alzheimer ' s disease2011
- Author(s)
  Villemagne VL, Okamura N, Drago J, Pejoska S, Mulligan RS, Chételat G, Ackermann U, O'Keefe G, Jones G, Gong S, T ochon-Danguy H, Kung HF, Pontecorvo MJ, Masters CL, Skovronsky D, Rowe CC
- Journal Title
  
  Arch Neurol
  
  Volume: 68 Issue: 7 Pages: 905-912
- DOI
  10.1001/archneurol.2011.142
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390297
[Journal Article] [^<18>F]-THK523, a novel in vivo tau imaging ligand for Alzheimer's disease.2011
- Author(s)
 Fodero-Tavoletti MT, Okamura N, Furumoto S, Mulligan RS, Connor A, McLean CA, Cao D, Rigopoulos A, O'Keefe G, Gong S, Adlard PA, Barnham KJ, Rowe CC, Masters CL, Kudo Y, Cappai R, Yanai K, Villemagne VL.
- Journal Title
 
 Brain 134
 
 Pages: 1089-1100
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-20591432
[Journal Article] アミロイドイメージングの現状と展望2011
- Author(s)
  岡村信行
- Journal Title
  
  老年期認知症研究会誌
  
  Volume: 18 Pages: 1-3
- URL
  http://www.rouninken.jp/member/pdf/18_pdf/vol.18_03-18-01.pdf
- Data Source
  KAKENHI-PROJECT-23390297
[Journal Article] Next-day Residual Sedative Effect after Nighttime Administration of an OTC Antihistamine Sleepaid, Diphenhydramine, Measured by Positron Emission Tomography2011
- Author(s)
  Zhang D, Tashiro M, Shibuya K, Okamura N, Funaki Y, Yoshikawa T, Kato M, Yanai K
- Journal Title
  
  J. Clin. Psychopharmacol
  
  Volume: 30(6) Pages: 694-701
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390171
[Journal Article] 認知症診断に用いられる検査診断学とバイオマーカー各論BF-227 によるアミロイドイメージング2011
- Author(s)
  岡村信行, 原田龍一, 古本祥三, 谷内一彦, 工藤幸司
- Journal Title
  
  日本臨床認知症学(上)
  
  Volume: 69(8) Pages: 556-560
- URL
  http://www.nippon-rinsho.co.jp/backnum/z_mokuji/6910ninti1.html
- Data Source
  KAKENHI-PROJECT-23390297
[Journal Article] Positron emission tomography evaluation of sedative properties of antihistamines2011
- Author(s)
  Yanai K, et al
- Journal Title
  
  Expert Opin Drug Saf
  
  Volume: 10(4) Issue: 4 Pages: 613-622
- DOI
  10.1517/14740338.2011.562889
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390171, KAKENHI-PROJECT-21590754, KAKENHI-PROJECT-23390297
[Journal Article] Roles of hypothalamic subgroup histamine and orexin neurons on behavioral responses to sleep deprivation induced by the treadmill method in adolescent rats2011
- Author(s)
  Xu A, Sakurai E, Kuramasu A, Zhang J, Li J, Okamura N, Zhang D, Yoshikawa T, Watanabe T, Yanai K
- Journal Title
  
  J. Pharmacol. Sci
  
  Volume: 114(4) Pages: 444-444
- NAID
  10029891159
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390171
[Journal Article] In vivo detection of prion amyloid plaques using[11C]BF-227 PET2010
- Author(s)
  Okamura N, et al.
- Journal Title
  
  European Journal of Nuclear Medicine and Molecular Imaging 37
  
  Pages: 934-941
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20019006
[Journal Article] In vivo visualization of α-synuclein deposition by [^<11>C]-BF-227 PET in multiple system atrophy.2010
- Author(s)
 Kikuchi A, Takeda A, Okamura N, Tashiro M, Hasegawa T, Furumoto S, Kobayashi M, Sugeno N, Baba T, Miki Y, Mori F, Wakabayashi K, Funaki Y, Fukuda H, Arai H, Kudo Y, Yanai K, Itoyama Y.
- Journal Title
 
 Brain 133
 
 Pages: 1772-1778
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-20591432
[Journal Article] Next-day residual sedative effect after nighttime administration of an over-the-counter antihistamine sleep aid, diphenhydramine, measured by positron emission tomography.2010
- Author(s)
  Zhang D, Tashiro M, Shibuya K, Okamura N, Funaki Y, Yoshikawa T, Kato M, Yanai K.
- Journal Title
  
  J Clin Psychopharmacol. 30
  
  Pages: 694-701
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591432
[Journal Article] In vivo detection of prion amyloid plaques using [^<11>C]BF-227 PET.2010
- Author(s)
 Okamura N, Shiga Y, Furumoto S, Tashiro M, Tsuboi Y, Furukawa K, Yanai K, Iwata R, Arai H, Kudo Y, Itoyama Y, Doh-ura K.
- Journal Title
 
 Eur J Nucl Med Mol Imaging. 37
 
 Pages: 934-941
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-20591432
[Journal Article] Florbetapir (^<18>F), a PET imaging agent that binds to amyloid plaques for detection of Alzheimer's disease.2010
- Author(s)
 Okamura N, Yanai K.
- Journal Title
 
 IDrugs 13
 
 Pages: 890-899
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-20591432
[Journal Article] Voxel-based analysis of amyloid PET probe [^<11>C]BF-227 uptake in mild cognitive impairment and Alzheimer's disease.2010
- Author(s)
 Shao H, Okamura N, Sugi K, Furumoto S, Furukawa K, Tashiro M, Iwata R, Matsuda H, Kudo Y, Arai H, Fukuda H, Yanai K.
- Journal Title
 
 Dement Geriatr Cogn Disord. 30
 
 Pages: 101-111
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-20591432
[Journal Article] In vivo measurement of vesicular monoamine transporter type 2 density in Parkinson's disease with ^<18>F-AV-133.2010
- Author(s)
 Okamura N, Villemagne VL, Drago J, Pejoska S, Dhamija RK, Mulligan RS, Ellis JR, Ackermann U, O'Keefe G, Jones G, Hughes A, Kung HF, Pontecorvo MJ, Skovronsky D, Rowe CC.
- Journal Title
 
 J Nucl Med. 51
 
 Pages: 223-228
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-20591432
[Journal Article] Roles of hypothalamic subgroup histamine and orexin neurons on behavioral responses to sleep deprivation induced by the treadmill method in adolescent rats.2010
- Author(s)
  Xu A, Sakurai E, Kuramasu A, Zhang J, Li J, Okamura N, Zhang D, Yoshikawa T, Watanabe T, Yanai K.
- Journal Title
  
  J Pharmacol Sci. 114
  
  Pages: 444-453
- NAID
  10029891159
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591432
[Journal Article] Geriatric medicine, Japanese Alzheimer's disease neuroimaging initiative and biomarker development2010
- Author(s)
  Arai H, Okamura N, Furukawa K, Kudo Y.
- Journal Title
  
  Tohoku J Exp Med. 221
  
  Pages: 87-95
- NAID
  10027084541
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591432
[Journal Article] Amyloid PET in mild cognitive impairment and Alzheimer's disease with BF-227: Comparison to FDG-PET.2010
- Author(s)
  Furukawa K, Okamura N, Tashiro M, Waragai M, Furumoto S, Iwata R, Yanai K, Kudo Y, Arai H.
- Journal Title
  
  J Neurol. 257
  
  Pages: 721-727
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591432
[Journal Article] In vivo measurement of vesicular monoamine transporter type 2 density in parkinson disease with(18)F-AV-133.2010
- Author(s)
  Okamura N, et al.
- Journal Title
  
  Journal of Nuclear Medicine 51
  
  Pages: 223-228
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591432
[Journal Article] In vivo detection of prion amyloid plaques using[11C]BF-227 PET.2010
- Author(s)
  Okamura N, et al.
- Journal Title
  
  European Journal of Nuclear Medicine and Molecular Imaging 37
  
  Pages: 934-941
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591432
[Journal Article] In vivo measurement of vesicular monoamine transporter type 2 density in parkinson disease with(18)F-AV-1332010
- Author(s)
  Okamura N, et al.
- Journal Title
  
  Journal of Nuclear Medicine 51
  
  Pages: 223-228
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20019006
[Journal Article] Advances in molecular imaging for the diagnosis of dementia.2009
- Author(s)
  Okamura N, Fodero-Tavoletti MT, Kudo Y, Rowe CC, Furumoto S, Arai H, Masters CL, Yanai K, Villemagne VL.
- Journal Title
  
  Expert Opin.Med.Diagn. 3
  
  Pages: 705-716
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591432
[Journal Article] Roles of the histaminergic neurotransmission on methamphetamine-induced locomotor sensitization and reward : a study of receptors gene knockout mice2009
- Author(s)
  Takino N, Sakurai E, Kuramasu A, Okamura N, Yanai K
- Journal Title
  
  Int Rev Neurobiol
  
  Volume: 85 Pages: 109-16
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390171
[Journal Article] Methamphetamine- and 3,4-methylenedioxymethamphetamine-induced behavioral changes in histamine H3-receptor knockout mice.2009
- Author(s)
  Okuda T, Zhang D, Shao H, Okamura N, Takino N, Iwamura T, Sakurai E, Yoshikawa T, Yanai K.
- Journal Title
  
  J Pharmacol Sci. 111
  
  Pages: 167-174
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591432
[Journal Article] Comparison study of amyloid PET and voxel-based morphometry analysis in mild cognitive impairment and Alzheimer's disease.2009
- Author(s)
  Waragai M, Okamura N, Furukawa K, Tashiro M, Furumoto S, Funaki Y, Kato M, Iwata R, Yanai K, Kudo Y, Arai H.
- Journal Title
  
  J Neurol Sci. 285
  
  Pages: 100-108
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591432
[Journal Article] 中枢に移行しない第二世代抗ヒスタミン薬 : PETによる脳内移行性に関する研究2009
- Author(s)
  谷内一彦, 田代学, 岡村信行
- Journal Title
  
  西日本皮膚科 1巻1号
  
  Pages: 3-6
- Data Source
  KAKENHI-PROJECT-19390061
[Journal Article] Methamphetamine-and 3, 4-Methylenedioxymethamphetamine-Induced Behavioral Changes in Histamine H(3)-Receptor Knockout Mice2009
- Author(s)
  Okuda T, Zhang D, Shao H, Okamura N, Takino N, Iwamura T, Sakurai E, Yoshikawa T, Yanai K
- Journal Title
  
  J Pharmacol Sci
  
  Volume: 111(2) Pages: 167-74
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390171
[Journal Article] Quantitative analysis of donepezil binding to acetylcholinesterase using positron emission tomography and [5-^<11>C-methoxy]donepezil.2009
- Author(s)
 Hiraoka K, Okamura N, Funaki Y, Watanuki S, Tashiro M, Kato M, Hayashi A, Hosokai Y, Yamasaki H, Fujii T, Mori E, Yanai K, Watabe H.
- Journal Title
 
 Neuroimage. 46
 
 Pages: 616-623
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-20591432
[Journal Article] In vitro characterisation of BF227 binding to alpha-synuclein/Lewy bodies.2009
- Author(s)
  Fodero-Tavoletti MT, Mulligan RS, Okamura N, Furumoto S, Rowe CC, Kudo Y, Masters CL, Cappai R, Yanai K, Villemagne VL.
- Journal Title
  
  Eur J Pharmacol. 617
  
  Pages: 54-58
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591432
[Journal Article] In vivo visualization of donepezil binding in the brain of patients with Alzheimer's disease.2008
- Author(s)
  Okamura N, et. al.
- Journal Title
  
  Br. J. Clin. Pharmacol. 65
  
  Pages: 472-479
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18019004
[Journal Article] Effects of a sedative antihistamine, D-chlorpheniramine, on regional cerebral perfusion and performance during simulated car driving2008
- Author(s)
  Tashiro M, Sakurada Y, Mochizuki H, Horikawa E, Maruyama M, Okamura N, Watanuki S, Arai H, Itoh M, Yanai K
- Journal Title
  
  Hum Psychopharmacol 23(2)
  
  Pages: 139-150
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390061
[Journal Article] Imaging amyloid pathology in the living brain.2008
- Author(s)
  Okamura N, Furumoto S, Arai H, Iwata R, Yanai K, Kudo Y.
- Journal Title
  
  Curr Med Imaging Rev. 4
  
  Pages: 56-62
- Data Source
  KAKENHI-PROJECT-20591432
[Journal Article] Imaging amyloid pathology in the living brain2008
- Author(s)
  Okamura N, et.al.
- Journal Title
  
  Curr Med Imaging Rev 4
  
  Pages: 56-62
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591432
[Journal Article] Blocking histamine H_1 improves learning and mnemonic dysfunction in mice with social isolation plus repeated methamphetamine injection.2008
- Author(s)
  Jia F, Mobarakeh JI, Dai H, Kato M, Xu A, Okuda T, Sakurai E, Okamura N, Takahashi K, Yanai K.
- Journal Title
  
  J Pharmacol Sci. 107
  
  Pages: 167-174
- NAID
  10024320914
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591432
[Journal Article] In vivo visualization of donepezil binding in the brain of patients with Alzheimer's disease2008
- Author(s)
  Okamura N, et.al.
- Journal Title
  
  Br J Clin Pharmacol 65
  
  Pages: 472-479
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20019006
[Journal Article] Discrete cortical regions associated with the musical beauty of major and minor chords2008
- Author(s)
  Suzuki, M., Okamura, N., Kawachi, Y., Tashiro, M., Arao, H., Hoshishiba, T., Gyoba, J., and Yanai, K.
- Journal Title
  
  Cognitive, Affective, & Behavioral Neuroscience (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18650063
[Journal Article] Effects of a sedative antihistamine, D-chlorpheniramine, on regional cerebral perfusion and performance during simulated car driving. 2008 Mar,;2008
- Author(s)
  Tashiro M, Sakurada Y, Mochizuki H, Horikawa E, Maruyama M, Okamura N, Watanuki S, Arai H, Itoh M, Yanai K.
- Journal Title
  
  Hum Psychopharmacol. Hum Psychopharmacol. 23(2)
  
  Pages: 139-150
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390061
[Journal Article] In vivo visualization of donepezil binding in the brain of patients with Alzheimer's disease2008
- Author(s)
  Okamura N, et.al.
- Journal Title
  
  Br J Clin Pharmacol 65
  
  Pages: 472-479
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591432
[Journal Article] Imaging amyloid pathology in the living brain2008
- Author(s)
  Okamura N, Furumoto S, Arai H, Iwata R, Yanai K, Kudo Y
- Journal Title
  
  Curr Med Imaging Rev 4
  
  Pages: 56-62
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390061
[Journal Article] Imaging amyloid pathology in the living brain2008
- Author(s)
  Okamura N, et.al.
- Journal Title
  
  Curr Med Imaging Rev 4
  
  Pages: 56-62
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20019006
[Journal Article] In vivo visualization of donepezil binding in the brain of patients with Alzheimer's disease.2008
- Author(s)
  Okamura, et. al.
- Journal Title
  
  Br J Clin Pharmacol. 65
  
  Pages: 320-325
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18790865
[Journal Article] In vivo visualization of donepezil binding in the brain of patients with Alzheimer's disease.2008
- Author(s)
  Okamura N, Funaki Y, Tashiro M, Kato M, Ishikawa Y, Maruyama M, Ishikawa H, Meguro K, Iwata R, Yanai K.
- Journal Title
  
  Br J Clin Pharmacol. 65
  
  Pages: 472-479
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591432
[Journal Article] In vivo visualization of donepezil binding in the brain of patients with Alzheimer's disease2008
- Author(s)
  Okamura N, Funaki Y, Tashiro M, Kato M, Ishikawa Y, Maruyama M, Ishikawa H, Meguro K, Iwata R, Yanai K
- Journal Title
  
  Br J Clin Pharmacol 65
  
  Pages: 472-479
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390061
[Journal Article] Discrete cortical regions associated with the musical beauty of major and minor chords.2008
- Author(s)
  Suzuki M, Okamura N, Kawachi Y, Tashiro M, Arao H, Hoshishiba T, Gyoba J, Yanai K.
- Journal Title
  
  Cogn Affect Behav Neurosci. 8
  
  Pages: 126-131
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591432
[Journal Article] Blocking histamine H1 improves learning and mnemonic dysfunction in mice with social isolation plus repeated methamphetamine injection2008
- Author(s)
  Jia F, Mobarakeh JI, Dai H, Kato M, Xu A, Okuda T, Sakurai E, Okamura N, Takahashi K, Yanai K
- Journal Title
  
  J Pharmacol Sci 107(2)
  
  Pages: 167-174
- NAID
  130000075818
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390061
[Journal Article] Effects of a sedative antihistamine, D-chlorpheniramine, on regional cerebral perfusion and performance during simulated car driving.2008
- Author(s)
  Tashiro M, Sakurada Y, Mochizuki H, Horikawa E, Maruyama M, Okamura N, Watanuki S, Arai H, Itoh M, Yanai K.
- Journal Title
  
  Hum Psychopharmacol. 23
  
  Pages: 139-150
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591432
[Journal Article] Discrete cortical regions are associated with the musical beauty of major and minor chords.2007
- Author(s)
  Suzuki, M., Okamura, N., Kawachi, Y., Tashiro, M., Arao, H., Hoshishiba, T, Gyoba, J., Yanai, K.
- Journal Title
  
  The 9the International Symposium on Future Medical Engineering Based on Bio-nanotechnology
  
  Pages: 7-9
- Data Source
  KAKENHI-PROJECT-18650063
[Journal Article] 和音聴取時のPETによる脳活動計測2007
- Author(s)
  鈴木美穂, 岡村信行, 河地庸介, 田代学, 荒生弘史, 星芝貴行, 行場次朗, 谷内一彦
- Journal Title
  
  東北心理学研究 56(印刷中)
- Data Source
  KAKENHI-PROJECT-18650063
[Journal Article] Selective cognitive dysfunction in mice lacking histamine H1 and H2 receptors.2007
- Author(s)
  Dai H, Kaneko K, Kato H, Fujii S, Jing Y, Sakurai E, Kato M, Okamura N, Kuramasu A, Yanai K.
- Journal Title
  
  Neuroscience Research 57(2)
  
  Pages: 306-313
- NAID
  10021189206
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390156
[Journal Article] Selective cognitive dysfunction in mice lacking histamine H1 and H2 receptors2007
- Author(s)
  Dai H, Kaneko K, Kato H, Fujii S, Jing Y, Sakurai E, Kato M, Okamura N, Kuramasu A, Yanai K.
- Journal Title
  
  Neuroscience Research 57(2)
  
  Pages: 306-313
- NAID
  10021189206
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18500286
[Journal Article] 脳内に移行する抗ヒスタミン薬の小児に与える影響2007
- Author(s)
  谷内一彦、岡村信行、田代学
- Journal Title
  
  小児科 48(10)
  
  Pages: 1435-1443
- NAID
  40015635049
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390061
[Journal Article] Selective cognitive dysfunction in mice lacking histamine H1 and H2 receptors2007
- Author(s)
  Dai H, Kaneko K, Kato H, Fujii S, Jing Y, Sakurai E. Kato M, Okamura N, Kuramasu A, Yanai K.
- Journal Title
  
  Neuroscience Research 57 (2)
  
  Pages: 306-13
- NAID
  10021189206
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18500286
[Journal Article] Neural correlates of perceptual difference between itching and pain: A human fMRI study2007
- Author(s)
  Mochizuki H, Sadato H, Saito D. N., Toyoda H, Tashiro M, Okamura N, Yanai K
- Journal Title
  
  Neuroimage 36
  
  Pages: 706-717
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390061
[Journal Article] Brain activity associated with dual-task management differs depending on the combinations of response modalities2007
- Author(s)
  Mochizuki H, Tashiro M, Gyoba J, Suzuki M, Okamura N, Itoh M, Yanai K
- Journal Title
  
  Brain Res 1172C
  
  Pages: 82-92
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390061
[Journal Article] Binding and safety profile of novel benzoxazole derivative for in vivo imaging of amyloid deposits in Alzheimer's disease.2007
- Author(s)
  Okamura N, et. al.
- Journal Title
  
  Geriatr. Gerontol. Int. 7
  
  Pages: 393-400
- NAID
  10020020907
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18019004
[Journal Article] Recent advances in the development of amyloid imaging agents2007
- Author(s)
  Furumoto S, Okamura N, Iwata R, Yanai K, Arai H, Kudo Y
- Journal Title
  
  Curr Top Med Chem 7(18)
  
  Pages: 1773-1789
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390061
[Journal Article] 5-yl]ethenyl)-6-(2-[fluoro]ethoxy)benz oxazole : A novel PET agent for in vivo detection of dense amyloid plaques in Alzheimer's disease patients.2007
- Author(s)
  Kudo Y, Okamura N, Furumoto S, Tashiro M, Furukawa K, Maruyama M, Itoh M, Iwata R, Yanai K, Arai H. 2-(2-[2-Dimethylaminothiazol-
- Journal Title
  
  J.Nucl.Med. 48(4)
  
  Pages: 553-561
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390156
[Journal Article] Binding and safety profile of novel benzoxazole derivative for in vivo imaging of amyloid deposits in Alzheimer's disease.2007
- Author(s)
  Okamura, et. al.
- Journal Title
  
  Geriatr Gerontol Int. 7
  
  Pages: 393-400
- NAID
  10020020907
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18790865
[Journal Article] PETによる分子・機能イメージングを組み合わせた脳機能研究2007
- Author(s)
  鈴木美穂, 岡村信行, 谷内一彦
- Journal Title
  
  認知神経科学 9(1)
  
  Pages: 62-65
- Data Source
  KAKENHI-PROJECT-19390061
[Journal Article] Neural correlates of perceptual difference between itching and pain : A human fMRI study.2007
- Author(s)
  Mochizuki H, Sadato H, Saito D.N., Toyoda H, Tashiro M, Okamura N, Yanai K.
- Journal Title
  
  Neuroimage (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390156
[Journal Article] Alzheimer's disease2007
- Author(s)
  Okamura N
- Journal Title
  
  Nippon Rinsho 65(2)
  
  Pages: 320-6
- Data Source
  KAKENHI-PROJECT-18500286
[Journal Article] Selective cognitive dysfunction in mice lacking histamine H1 and H2 receptors2007
- Author(s)
  Dai H, Kaneko K, Kato H, Fujii S, Jing Y, Sakurai E, Kato M, Okamura N, Kuramasu A, Yanai K
- Journal Title
  
  Neuroscience Research 57(2)
  
  Pages: 306-313
- NAID
  10021189206
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390061
[Journal Article] Effects of histamine H3 antagonists and donepezil on learning and mnemonic deficits induced by pentylenetetrazol kindling in weanling mice.2006
- Author(s)
  FY Jia, M.Kato, H.Dai, AJ Xu, T.Okuda, E.Sakurai, N.Okamura, T.W.Lovenberg, A.Barbier, N.I.Carruthers, K.Iinuma, K.Yanai.
- Journal Title
  
  Neuropharmacology 50(4)
  
  Pages: 404-411
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390156
[Journal Article] Effects of Histamine H3 antagonists and Donepezil on Learning and Mnemonic Deficits Induced by Pentylenetetrazol Kindling in Weanling Mice2006
- Author(s)
  Jia F, Kato M, Dai H, Xu A, Okuda T, Sakurai E. Okamura N, Lovenberg TW, Barbier A, Carruthers NI, Iinuma K, Yanai K.
- Journal Title
  
  Neurophamacology 50 (4)
  
  Pages: 404-411
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18500286
[Journal Article] Effects of Histamine H3 antagonists and Donepezil on Learning and Mnemonic Deficits Induced by Pentylenetetrazol Kindling in Weanling Mice2006
- Author(s)
  Jia F, Kato M, Dai H, Xu A, Okuda T, Sakurai E, Okamura N, Lovenberg TW, Barbier A, Carruthers NI, Iinuma K, Yanai K,
- Journal Title
  
  Neurophamacology, 50(4)
  
  Pages: 404-411
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18500286
[Journal Article] 老人斑および神経原線維変化の非侵襲的検出を目的とした新規PETプローブの開発研究2006
- Author(s)
  岡村信行
- Journal Title
  
  東北医学雑誌 118
  
  Pages: 143-147
- NAID
  120003660396
- Data Source
  KAKENHI-PROJECT-18790865
[Journal Article] アミロイドイメージングの進歩2006
- Author(s)
  岡村信行
- Journal Title
  
  Dementia Japan 20
  
  Pages: 216-225
- Data Source
  KAKENHI-PROJECT-18790865
[Journal Article] Quinoline and Benzimidazole Derivatives : Candidate Probes for In Vivo Imaging of Tau Pathology in Alzheimer's Disease.2005
- Author(s)
  Okamura N et al.
- Journal Title
  
  J Neurosci 25
  
  Pages: 10857-10862
- Data Source
  KAKENHI-PROJECT-16790714
[Journal Article] PETを用いた脳機能の分子イメージング法2005
- Author(s)
  岡村信行, 谷内一彦
- Journal Title
  
  日本薬理学雑誌 126
  
  Pages: 347-352
- NAID
  10016912895
- Data Source
  KAKENHI-PROJECT-16790714
[Journal Article] Quinoline and benzimidazole derivatives candidate probes for in vivo imaging of tau pathology in Alzheimer's disease.2005
- Author(s)
  Okamura N, Suemoto T, Furumoto S, Suzuki M; Shimadzu H, Akatsu H, Yamamoto T, Fujiwara H, Nemoto M, Maruyama M, Arai H, Yanai K, Sawada T, Kudo Y.
- Journal Title
  
  J Neurosci. 25(47)
  
  Pages: 10857-10862
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390156
[Journal Article] Quinoline and benzimidazole derivatives : candidate probes for in vivo imaging of tau pathology in Alzheimer's disease.2005
- Author(s)
  Okamura N, Yanai K, et al.
- Journal Title
  
  J.Neurosci. 25・47
  
  Pages: 10857-10862
- Data Source
  KAKENHI-PROJECT-17390156
[Journal Article] 老人斑を生体画像化する新規PETプローブの開発2005
- Author(s)
  岡村信行
- Journal Title
  
  東北医学雑誌 117
  
  Pages: 50-52
- Data Source
  KAKENHI-PROJECT-16790714
[Journal Article] Quinoline and benzimidazole derivatives : candidate probes for in vivo imaging of tau pathology in Alzheimer's disease.2005
- Author(s)
  Okamura N, Yanai K, et al.
- Journal Title
  
  J Neurosci. 25(47)
  
  Pages: 10857-10862
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390156
[Journal Article] A novel imaging probe for in vivo detection of neuritic and diffuse amyloid In the brain.2004
- Author(s)
  N.Okamura et al.
- Journal Title
  
  J.Mol.Neurosci. 24
  
  Pages: 189-197
- Data Source
  KAKENHI-PROJECT-15659126
[Journal Article] Anovel imaging probe for in vivo detection of neuritic and diffuse amyloid plaques in the brain.2004
- Author(s)
  Okamura N
- Journal Title
  
  Journal of Molecular Neuroscience 24・2
  
  Pages: 247-255
- Data Source
  KAKENHI-PROJECT-16790714
[Journal Article] Styrylbenzoxazole derivatives for in vivo imaging of amyloid plaques in the brain.2004
- Author(s)
  Okamura N
- Journal Title
  
  Journal of Neuroscience 24・10
  
  Pages: 2535-2541
- Data Source
  KAKENHI-PROJECT-16790714
[Journal Article] 生体における脳アミロイドの画像化2004
- Author(s)
  岡村信行
- Journal Title
  
  日本老年医学会雑誌 41・2
  
  Pages: 175-178
- NAID
  10013289710
- Data Source
  KAKENHI-PROJECT-16790714
[Journal Article] 脳アミロイドを生体画像化する新規PETトレーサーの開発2004
- Author(s)
  岡村信行
- Journal Title
  
  東北医学会雑誌 116・1
  
  Pages: 93-96
- Data Source
  KAKENHI-PROJECT-16790714
[Journal Article] 脳アミロイドの画像化2004
- Author(s)
  岡村信行
- Journal Title
  
  老年精神医学雑誌 15・Suppl
  
  Pages: 29-35
- Data Source
  KAKENHI-PROJECT-16790714
[Journal Article] Greater responsiveness to donepezil in Alzheimer patients with higher levels of acetylcholinesterase based on attention task scores and a donepezil PET study Alzheimer Disease & Associated Disorders
- Author(s)
  Masashi Kasuya, Kenichi Meguro, Nobuyuki Okamura, Yoshihito Funaki, Hiroyasu Ishikawa, Naofumi Tanaka, Ren Iwata, Kazuhiko Yanai
- Journal Title
  
  Epub
  
  Volume: 2011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591543
[Journal Article] Noninvasive assessment of Alzheimer ' s disease neurofibrillary pathology using ^(18)F-THK5105 PET
- Author(s)
  Okamura N, Furumoto S, Fodero-Tavoletti MT, Mulligan RS, Harada R, Y ates P, Pejoska S, Kudo Y, Masters CL, Y anai K, Rowe CC, Villemagne VL
- Journal Title
  
  Brain
  
  Volume: (印刷中)
- URL
  http://brain.oxfordjournals.org/content/early/2014/03/27/brain.awu064.long
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390297
[Patent] モノアミンオキシダーゼBイメージングプローブ2018
- Inventor(s)
  原田龍一、古本祥三、工藤幸司、岡村信行
- Industrial Property Rights Holder
  国立大学法人東北大学
- Industrial Property Rights Type
  特許
- Filing Date
  2018
- Data Source
  KAKENHI-PROJECT-18H02771
[Patent] タウイメージングプローブ2011
- Inventor(s)
  工藤幸司, 岡村信行, 古本祥三
- Industrial Property Rights Holder
  国立大学法人東北大学
- Industrial Property Rights Type
  特許
- Filing Date
  2011-10-28
- Overseas
- Data Source
  KAKENHI-PROJECT-23390297
[Patent] フッ素およびヒドロキシ基で置換されたアルコキシ基を有するPETプローブ2007
- Inventor(s)
  工藤幸司、古本祥三、岡村信行
- Industrial Property Rights Holder
  東北大学
- Industrial Property Number
  2007-176366
- Filing Date
  2007-07-04
- Data Source
  KAKENHI-PROJECT-18019004
[Patent] コンフォーメーション病の診断用プローブ2006
- Inventor(s)
  工藤幸司, 荒井啓行, 岡村信行, 丸山将浩, 古本祥三, 堂浦克実
- Industrial Property Rights Holder
  国立大学法人東北大学
- Filing Date
  2006-12-25
- Data Source
  KAKENHI-PROJECT-18019004
[Patent] コンフォーメーション病の診断用プローブ2006
- Inventor(s)
  工藤幸司, 荒井啓行, 岡村信行, 丸山将浩, 古本祥三, 堂浦克実
- Industrial Property Rights Holder
  国立大学法人東北大学
- Filing Date
  2006-12-25
- Data Source
  KAKENHI-PROJECT-18790865
[Presentation] Recent advances in PET imaging of reactive astrogliosis.2023
- Author(s)
  Okamura N.
- Organizer
  SNMMI 2023 Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K07069
[Presentation] 新規タウPETトレーサー[18F]SNFT-1の前臨床評価2023
- Author(s)
  岡村信行，原田龍一，ルーッスィリスックプラディット，清水悠暉，横山裕香，堵怡青，工藤幸司，古本祥三．
- Organizer
  第44回日本臨床薬理学会学術総会
- Data Source
  KAKENHI-PROJECT-22KK0123
[Presentation] Recent advances in PET imaging of reactive astrogliosis.2023
- Author(s)
  Okamura N.
- Organizer
  SNMMI 2023 Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22KK0123
[Presentation] Development of a highly sensitive tau tracer 18F-SNFT-1 for imaging early tau pathology in Alzheimer’s disease2023
- Author(s)
  Okamura N, Harada R, Lerdsirisuk P, Shimizu Y, Yokoyama Y, Du Y, Ezura M, Arai H, Kudo Y, Furumoto S
- Organizer
  AD/PD2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19KK0212
[Presentation] Development of a highly sensitive tau tracer 18F-SNFT-1 for imaging early tau pathology in Alzheimer's disease.2023
- Author(s)
  Okamura N, Harada R, Lerdsirisuk P, Shimizu Y, Yokoyama Y, Du Y, Ezura M, Arai H, Kudo Y, Furumoto S.
- Organizer
  AD/PD2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02771
[Presentation] 新規タウPETトレーサー[18F]SNFT-1の前臨床評価2023
- Author(s)
  岡村信行，原田龍一，ルーッスィリスックプラディット，清水悠暉，横山裕香，堵怡青，工藤幸司，古本祥三．
- Organizer
  第44回日本臨床薬理学会学術総会
- Data Source
  KAKENHI-PROJECT-23K07069
[Presentation] Visualizing reactive astrogliosis using positron emission tomography.2023
- Author(s)
  Okamura N.
- Organizer
  The 13th BRI International Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02771
[Presentation] Visualizing reactive astrogliosis using positron emission tomography.2023
- Author(s)
  Okamura N
- Organizer
  The 13th BRI International Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19KK0212
[Presentation] Analysis of [18F]SMBT-1 binding to reactive astrogliosis in postmortem brain tissues from patients with Alzheimer's disease and frontotemporal lobar degeneration.2023
- Author(s)
  Okamura N, Harada R, Du Y, Yokoyama Y, Kudo Y, Tashiro M, Furumoto S.
- Organizer
  SNMMI 2023 Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22KK0123
[Presentation] Visualizing reactive astrogliosis using positron emission tomography.2023
- Author(s)
  Okamura N.
- Organizer
  The 13th BRI International Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22KK0123
[Presentation] Development of a highly sensitive tau tracer 18F-SNFT-1 for imaging early tau pathology in Alzheimer’s disease.2023
- Author(s)
  Okamura N, Harada R, Lerdsirisuk P, Shimizu Y, Yokoyama Y, Du Y, Ezura M, Arai H, Kudo Y, Furumoto S.
- Organizer
  AD/PD2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22KK0123
[Presentation] Analysis of [18F]SMBT-1 binding to reactive astrogliosis in postmortem brain tissues from patients with Alzheimer's disease and frontotemporal lobar degeneration.2023
- Author(s)
  Okamura N, Harada R, Du Y, Yokoyama Y, Kudo Y, Tashiro M, Furumoto S.
- Organizer
  SNMMI 2023 Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K07069
[Presentation] 神経炎症モデルラットにおけるグリア線維性酸性タンパク質イメージング手法の開発2022
- Author(s)
  盛戸貴裕, 原田龍一, 岩田錬, 岡村信行, 谷内一彦
- Organizer
  第23回応用薬理学会シンポジウム
- Data Source
  KAKENHI-PROJECT-19KK0212
[Presentation] PET imaging of reactive astrocytes with [18F]SMBT-1 in dementia.2022
- Author(s)
  Okamura N.
- Organizer
  13th Congress of the World Federation of Nuclear Medicine and Biology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02771
[Presentation] PET tracer SMBT-1 discriminates between BU99008 and Deprenyl binding sites on reactive astrocytes in Alzheimer's disease brain2022
- Author(s)
  Fontana IC, Kumar A, Okamura N, Nordberg A
- Organizer
  AAIC 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19KK0212
[Presentation] フェルラ酸誘導体のαシヌクレイン凝集・抑制効果の検討2022
- Author(s)
  原田龍一, 陳梦格, 工藤幸司, 谷内一彦, 岡村信行
- Organizer
  第23回応用薬理学会シンポジウム
- Data Source
  KAKENHI-PROJECT-19KK0212
[Presentation] 認知症克服へ向けた薬剤開発の現状と展望2022
- Author(s)
  岡村信行
- Organizer
  第23回応用薬理学会シンポジウム
- Data Source
  KAKENHI-PROJECT-19KK0212
[Presentation] [18F]SNFT-1の結合選択性評価および第二世代タウPET トレーサーとのADタウに対する結合性比較2022
- Author(s)
  清水悠暉，原田龍一，横山裕香，Pradith Lerdsirisuk，石川洋一，岩田錬，工藤幸司，谷内一彦，岡村信行，古本祥三
- Organizer
  第5回日本核医学会分科会　放射性薬品科学研究会
- Data Source
  KAKENHI-PROJECT-19KK0212
[Presentation] Development of novel PET tracer [18F]SMBT-1 for imaging reactive astrogliosis.2022
- Author(s)
  Okamura N.
- Organizer
  Invited Lecture, Center for Cognition and Sociality, Institute for Basic Science, South Korea
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22KK0123
[Presentation] 第二世代タウPETトレーサーの結合性比較2022
- Author(s)
  横山裕香，原田龍一，Pradith Lerdsirisuk，清水悠暉，堵怡青，石川洋一，工藤幸司，岡村信行，荒井啓行，谷内一彦
- Organizer
  第95回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-19KK0212
[Presentation] ヒト脳内の神経炎症を非侵襲的に可視化する画像診断技術2022
- Author(s)
  岡村信行
- Organizer
  第96回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-18H02771
[Presentation] ヒト脳内の神経炎症を非侵襲的に可視化する画像診断技術2022
- Author(s)
  岡村信行
- Organizer
  第96回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-22KK0123
[Presentation] Development of novel PET tracer [18F]SMBT-1 for imaging reactive astrogliosis.2022
- Author(s)
  Okamura N.
- Organizer
  Invited Lecture, Center for Cognition and Sociality, Institute for Basic Science, South Korea
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02771
[Presentation] PET imaging of reactive astrocytes with [18F]SMBT-1 in dementia2022
- Author(s)
  Okamura N
- Organizer
  13th Congress of the World Federation of Nuclear Medicine and Biology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19KK0212
[Presentation] Physiological uptake of [18F]SMBT-1, a new astrogliosis tracer, in whole-body organs2022
- Author(s)
  Tashiro M, Ishioka Y, Mesfin B, Watanuki S, Hiraoka K, Harada R, Furumoto S, Okamura N, Yanai K, Watabe H
- Organizer
  13th Congress of the World Federation of Nuclear Medicine and Biology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19KK0212
[Presentation] Development of novel PET tracer [18F]SMBT-1 for imaging reactive astrogliosis2022
- Author(s)
  Okamura N
- Organizer
  Center for Cognition and Sociality, Institute for Basic Science
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19KK0212
[Presentation] アルツハイマー病の画像診断と治療の最前線．2022
- Author(s)
  岡村信行
- Organizer
  第147回日本医学放射線学会北日本地方会・第92回日本核医学会北日本地方会
- Data Source
  KAKENHI-PROJECT-19KK0212
[Presentation] 認知症疾患の層別化における[18F]SMBT-1の有用性の検討プロジェクトの経過報告 20222022
- Author(s)
  田代学, 平岡宏太良, 平岡宏太良, 冨田尚希, 石木愛子, 小林良太, 四月朔日聖一, メスフィンベリフ, 武田和子, 草場美津江, 菊池昭夫, 渡部浩司, 麦倉俊司, 古川勝敏, 加藤隆司, 石井賢二, 川勝忍, 原田龍一, 古本祥三, 岡村信行．
- Organizer
  第41回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-19KK0212
[Presentation] PET imaging of reactive astrocytes with [18F]SMBT-1 in dementia.2022
- Author(s)
  Okamura N.
- Organizer
  13th Congress of the World Federation of Nuclear Medicine and Biology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22KK0123
[Presentation] レビー小体型認知症(DLB)剖検脳を用いた神経炎症PETプローブの結合性評価2022
- Author(s)
  横山裕香, 原田龍一, 石川洋一, 岩田錬, 工藤幸司, 谷内一彦, 村山繁雄, 岡村信行, 古本祥三
- Organizer
  第23回応用薬理学会シンポジウム
- Data Source
  KAKENHI-PROJECT-19KK0212
[Presentation] ヒト脳内の神経炎症を非侵襲的に可視化する画像診断技術2022
- Author(s)
  岡村信行
- Organizer
  第96回日本薬理学会年会創薬シーズ特設シンポジウム
- Data Source
  KAKENHI-PROJECT-19KK0212
[Presentation] ヒト剖検脳を用いたTDP-43型前頭側頭葉変性症における[18F]SMBT-1の有用性の検討2022
- Author(s)
  横山裕香, 原田龍一, 石川洋一, 岩田錬, 工藤幸司, 岩崎靖, 谷内一彦, 岡村信行, 古本祥三
- Organizer
  第5回日本核医学会分科会　放射性薬品科学研究会
- Data Source
  KAKENHI-PROJECT-19KK0212
[Presentation] 前頭側頭型変性症で認めるアストロサイト様構造物に対するアミロイド・タウPETプローブの結合性評価2021
- Author(s)
  横山裕香，原田龍一，荒井啓行，工藤幸司，古本祥三，岡村信行，谷内一彦
- Organizer
  第72回日本薬理学会北部会
- Data Source
  KAKENHI-PROJECT-19KK0212
[Presentation] 中枢神経系病理を可視化するPETトレーサー開発の現状2021
- Author(s)
  岡村信行
- Organizer
  第10回日本認知症予防学会学術集会
- Data Source
  KAKENHI-PROJECT-18H02771
[Presentation] アストロサイト画像化を目的とした PETプローブ[18F]SMBT-1の代謝特性の検討2021
- Author(s)
  原田龍一、堵怡青、工藤幸司、岡村信行、古本祥三、谷内一彦
- Organizer
  日本分子イメージング学会・第15回総会・学術総会
- Data Source
  KAKENHI-PROJECT-19KK0212
[Presentation] Amyloid, tau and reactive astrocytosis imaging in aging and Alzheimer’s disease2021
- Author(s)
  Victor L Villemagne Ryuichi Harada, Vincent Dore, Shozo Furumoto, Rachel Mulligan, Yukitsuka Kudo, Samantha Burnham, Natasha Krishnadas, Kun Huang, Kazuhiko Yanai, Christopher C Rowe, and Nobuyuki Okamura
- Organizer
  ADPD2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19KK0212
[Presentation] アルツハイマー病におけるアストログリオーシスの画像化2021
- Author(s)
  岡村信行、原田龍一
- Organizer
  第36回日本老年精神医学会大会
- Data Source
  KAKENHI-PROJECT-18H02771
[Presentation] Off-target結合のない新規タウPETプローブの開発2021
- Author(s)
  清水悠暉, 原田龍一, Pradith Lerdsirisuk, 堵怡青, 工藤幸司, 石川洋一, 岩田錬, 岡村信行, 谷内一彦, 古本祥三
- Organizer
  第61回日本核医学会
- Data Source
  KAKENHI-PROJECT-19KK0212
[Presentation] 反応性アストロサイトを標的としたPET プローブ [18F]SMBT-12021
- Author(s)
  原田龍一, 工藤幸司, 荒井啓行, 田代学, 古本祥三, 岡村信行, 谷内一彦
- Organizer
  第42回日本臨床薬理学会学術総会
- Data Source
  KAKENHI-PROJECT-19KK0212
[Presentation] アルツハイマー病脳病理像のPETイメージング2021
- Author(s)
  岡村信行
- Organizer
  第42回日本臨床薬理学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-19KK0212
[Presentation] 第二世代タウPETトレーサーの結合性の比較2021
- Author(s)
  原田龍一，Pradith Lerdsirisuk，清水悠暉，堵怡青，石川洋一, 荒井啓行, 工藤幸司，岩田錬, 谷内一彦，古本祥三，岡村信行
- Organizer
  第61回日本核医学会
- Data Source
  KAKENHI-PROJECT-19KK0212
[Presentation] アミロイド・タウPETプローブのアストロサイト様構造物に対する結合性評価2021
- Author(s)
  横山裕香, 原田龍一, 荒井啓行, 工藤幸司, 古本祥三, 岡村信行&, 谷内一彦
- Organizer
  第40回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-19KK0212
[Presentation] 嗜銀顆粒性認知症に対するPETバイオマーカーの探索2021
- Author(s)
  原田龍一，堵恰青， Pradith Lerdsirisuk, 工藤幸司，古本祥三，岡村信行，谷内一彦
- Organizer
  第72回日本薬理学会北部会
- Data Source
  KAKENHI-PROJECT-19KK0212
[Presentation] アルツハイマー病患者における反応性アストロサイトの画像化2021
- Author(s)
  岡村信行、原田龍一、古本祥三、石木愛子、工藤幸司、荒井啓行、Christopher C Rowe、Victor L Villemagne
- Organizer
  第10回日本認知症予防学会学術集会
- Data Source
  KAKENHI-PROJECT-18H02771
[Presentation] オフターゲット結合を示さない高感度タウPETプローブの開発2021
- Author(s)
  原田龍一，Pradith Lerdsirisuk，清水悠暉，堵怡青，石川洋一, 荒井啓行, 工藤幸司，谷内一彦，岩田錬, 古本祥三，岡村信行
- Organizer
  放射性薬品科学研究会2021
- Data Source
  KAKENHI-PROJECT-19KK0212
[Presentation] PHFタウへの感度・特異度を高めた新規タウプローブ[18F]SNFT-1の開発2021
- Author(s)
  岡村信行、原田龍一、清水悠暉、Pradith Lerdsirisuk、堵怡青、石川洋一、荒井啓行、谷内一彦、工藤幸司、古本祥三
- Organizer
  第40回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-18H02771
[Presentation] Development of novel imaging biomarker for reactive astrogliosis.2021
- Author(s)
  Okamura N
- Organizer
  Joint Symposium on Nuclear Cardiology & Neurology Taiwan Society of Nuclear Medicine
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02771
[Presentation] 健常者を対象としたPET診断薬18F-SMBT-1の全身臓器における生理的集積の観察2021
- Author(s)
  石岡有生、四月朔日聖一、平岡宏太良、石川洋一、船木善仁、原田龍一、岡村信行、荒井啓行、古本祥三、谷内一彦、渡部浩司、田代学
- Organizer
  第42回日本臨床薬理学会学術総会
- Data Source
  KAKENHI-PROJECT-19KK0212
[Presentation] ヒト剖検脳に対するMAO-B PETプローブ[18F]SMBT-1の結合2021
- Author(s)
  原田龍一、堵怡青、横山裕香、古本祥三、工藤幸司、荒井啓行、畠野雄也4 、石原智彦4 、小野寺理、吉田眞理、北本哲之、岩崎靖、谷内一彦、岡村信行
- Organizer
  第40回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-19KK0212
[Presentation] PHFタウへの感度・特異度に優れた新規タウプローブ[18F]SNFT-1の開発2021
- Author(s)
  岡村信行、原田龍一、清水悠暉、Pradith Lerdsirisuk、堵怡青、石川洋一、荒井啓行、谷内一彦、工藤幸司、古本祥三
- Organizer
  第40回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-19KK0212
[Presentation] Evaluation of the novel 18F-labeled PET tracer SMBT-1 for imaging astrogliosis in healthy elderly controls and in Alzheimer’s disease2020
- Author(s)
  Victor L Villemagne Ryuichi Harada, Vincent Dore, Shozo Furumoto, Rachel Mulligan, Yukitsuka Kudo, Samantha Burnham, Natasha Krishnadas, Kun Huang, Kazuhiko Yanai, Christopher C Rowe, and Nobuyuki Okamura
- Organizer
  AAIC2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19KK0212
[Presentation] アミロイド・タウPETの現状と新規プローブ開発2020
- Author(s)
  岡村信行
- Organizer
  第38回日本神経治療学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02771
[Presentation] 反応性アストロサイトのPETイメージング2020
- Author(s)
  岡村信行
- Organizer
  第39回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-18H02771
[Presentation] 反応性アストロサイトのPETイメージング2020
- Author(s)
  岡村信行
- Organizer
  第61回日本神経学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02771
[Presentation] Assessment of reactive astrogliosis in patients with Alzheimer’s disease using novel PET tracer 18F-SMBT-1.2020
- Author(s)
  岡村信行、原田龍一、Vincent Dore、古本祥三、Rachel Mulligan、工藤幸司、Natasha Krishnadas、Kun Huang、谷内一彦、Christopher C Rowe、Victor L Villemagne
- Organizer
  Neuroscience 2020
- Data Source
  KAKENHI-PROJECT-18H02771
[Presentation] Preclinical characterization of [18F]THK-5562, a novel tau PET tracer with little off-target binding2020
- Author(s)
  Harada R, Lerdsirisuk P, Du Y, Ezura M, Shimizu Y, Morito T, Arai H, Yanai K,Kudo Y, Furumoto S, Okamura N
- Organizer
  HUMAN AMYLOID IMAGING CONFERENCE 2020（マイアミ）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19KK0212
[Presentation] Evaluation of the novel 18F-labeled PET tracer SMBT-1 for imaging astrogliosis in Alzheimer’s disease.2020
- Author(s)
  Okamura N, Harada R, Dore V, Furumoto S, Mulligan R, Kudo Y, Krishnadas N, Huang K, Yanai K, Rowe CC, Villemagne VL.
- Organizer
  SNMMI 2020 Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02771
[Presentation] Development and Identification of [18F]SNFT-1 (THK-5562), a Promising Candidate for Selective Tau PET Tracer in Alzheimer’s Disease2020
- Author(s)
  Pradith Lerdsirisuk, Ryuichi Haradac, Yuki Shimizub, Yiqing Du, Yoichi Ishikawa, Ren Iwata, Kazuhiko Yanai, Yukitsuka Kudo, Nobuyuki Okamurab, Shozo Furumoto
- Organizer
  EANM2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19KK0212
[Presentation] Imaging astrogliosis and non-TSPO microglial activation.2019
- Author(s)
  Okamura Nobuyuki
- Organizer
  Society of Nuclear Medicine and Molecular Imaging 2019 Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02771
[Presentation] PET imaging of neuropathology in Alzheimer’s disease.2019
- Author(s)
  Okamura Nobuyuki
- Organizer
  3th International Symposium on Molecular Imaging, Havana, Cuba
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02771
[Presentation] アストログリオーシスを生体画像化する新規PETプローブ[18F]SMBT-1の開発2019
- Author(s)
  岡村信行、原田龍一、江面道典、古本祥三、谷内一彦、荒井啓行、工藤幸司
- Organizer
  第38回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-18H02771
[Presentation] Development of a novel 18F-labeled PET tracer for imaging astrogliosis.2019
- Author(s)
  Okamura Nobuyuki, Harada Rryuichi, Ezura Michinori, Arai Hiroyuki, Yanai Kazuhiko, Furumoto Syozo, Kudo Yukitsuka
- Organizer
  AAIC 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02771
[Presentation] 認知症の画像診断 Update2019
- Author(s)
  岡村信行
- Organizer
  第61回日本老年医学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02771
[Presentation] Potential application of 18F-THK5351 and its derivatives for PET imaging of astrogliosis in human brain.2018
- Author(s)
  Okamura Nobuyuki、Harada Ryuichi
- Organizer
  AAIC 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02771
[Presentation] 認知症の画像診断の最先端2018
- Author(s)
  岡村信行、原田龍一
- Organizer
  第33回日本老年精神医学会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02771
[Presentation] 認知症の画像診断の最先端2018
- Author(s)
  岡村信行、原田龍一
- Organizer
  第33回日本老年精神医学会
- Invited
- Data Source
  KAKENHI-PROJECT-16K15570
[Presentation] Development of PET tracers for imaging amyloid, tau and gliosis.2018
- Author(s)
  岡村信行、原田龍一
- Organizer
  第58回日本核医学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-16K15570
[Presentation] Toward the development of novel imaging agents for protein misfolding diseases.2018
- Author(s)
  Okamura Nobuyuki
- Organizer
  2018 International Conference on Neurodegenerative Disorders, CGMH
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02771
[Presentation] Development of PET tracers for imaging amyloid, tau and gliosis.2018
- Author(s)
  岡村信行、原田龍一
- Organizer
  第58回日本核医学会学術集会
- Data Source
  KAKENHI-PROJECT-18H02771
[Presentation] Structure-binding relationship of quinoline derivatives on monoamine oxidase B.2018
- Author(s)
  Okamura N.
- Organizer
  The 12th Human Amyloid Imaging (HAI) meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04900
[Presentation] Toward the development of novel imaging agents for protein misfolding diseases.2018
- Author(s)
  Okamura N.
- Organizer
  2018 International Conference on Neurodegenerative Disorders, CGMH
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15570
[Presentation] 認知症を標的とした分子イメージングプローブ開発の現状2017
- Author(s)
  岡村信行
- Organizer
  第32回日本老年精神医学会
- Invited
- Data Source
  KAKENHI-PROJECT-15H04900
[Presentation] 18F-THK5351 PET in corticobasal syndrome2017
- Author(s)
  Kikuchi A, Okamura N, Hasegawa T, Ezura M, Baba T, Sugeno N, Yoshida S, Kobayashi J, Arai H, Furumoto S, Tashiro M, Yanai K, Kudo Y, Takeda A, Aoki M
- Organizer
  XXIII World Congress of Neurology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461303
[Presentation] 認知症を標的とした分子イメージングプローブ開発の現状2017
- Author(s)
  岡村信行
- Organizer
  第60回日本脳循環代謝学会学術集会
- Data Source
  KAKENHI-PROJECT-15H04900
[Presentation] Imaging tau and astrocyte with 18F-THK5351 - analysis of autopsy cases -.2017
- Author(s)
  Okamura N.
- Organizer
  Society of Nuclear Medicine and Molecular Imaging
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04900
[Presentation] THK5351-PETイメージングの有用性と課題2017
- Author(s)
  岡村信行
- Organizer
  第36回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-15H04900
[Presentation] 大脳皮質基底核症候群における18F-THK5351 PETの経時的変化2017
- Author(s)
  菊池昭夫、江面道典、岡村信行、長谷川隆文、石木愛子、原田龍一、荒井啓行、谷内一彦、古本祥三、田代学、工藤幸司、武田篤、青木正志
- Organizer
  第36回日本認知症学会
- Data Source
  KAKENHI-PROJECT-26461303
[Presentation] Amyloid and Tau Imaging in Neurodegenerative Diseases.2017
- Author(s)
  Okamura N.
- Organizer
  XXIII World Congress of Neurology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04900
[Presentation] Novel tracer development and potential application for movement disorders.2017
- Author(s)
  Okamura N.
- Organizer
  3rd Taiwan International Congress of Parkinson's Disease and Movement Disorders
- Place of Presentation
  台北（台湾）
- Year and Date
  2017-03-19
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15570
[Presentation] 認知症を標的とした分子イメージングプローブ開発の現状2017
- Author(s)
  岡村信行
- Organizer
  第60回日本脳循環代謝学会学術集会
- Data Source
  KAKENHI-PROJECT-16K15570
[Presentation] 認知症を標的とした分子イメージングプローブ開発の現状2017
- Author(s)
  岡村信行
- Organizer
  第32回日本老年精神医学会
- Invited
- Data Source
  KAKENHI-PROJECT-16K15570
[Presentation] THK5351 PET imaging in Alzheimer’s disease and non-AD tauopathies.2017
- Author(s)
  Okamura N.
- Organizer
  International tau symposium
- Data Source
  KAKENHI-PROJECT-15H04900
[Presentation] Recent clinical studies with THK tau tracers.2016
- Author(s)
  Okamura N.
- Organizer
  SNMMI 2016 Annual Meeting
- Place of Presentation
  San Diego, USA
- Year and Date
  2016-06-13
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04900
[Presentation] Novel PET Probes for Imaging of Tau in Alzheimer's Disease.2016
- Author(s)
  Okamura N.
- Organizer
  Symposium of Medical Imaging; PET/MR and Molecular Images
- Place of Presentation
  Taipei, Taiwan
- Year and Date
  2016-10-29
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04900
[Presentation] Longitudinal analysis of [18F]THK5351 tau PET images in patients with Alzheimer's disease and corticobasal syndrome.2016
- Author(s)
  Okamura N, Harada R, Ishiki A, Furukawa K, Kikuchi A, Hasegawa T, Aoki M, Furumoto S, Tashiro M, Yanai K, Arai H, Kudo Y.
- Organizer
  CTAD 2016
- Place of Presentation
  San Diego, USA
- Year and Date
  2016-12-10
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04900
[Presentation] Development of THK tau tracers.2016
- Author(s)
  Okamura N.
- Organizer
  Tau PET Futures Meeting
- Place of Presentation
  San Francisco, USA
- Year and Date
  2016-10-13
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04900
[Presentation] タウPETイメージングの現状と可能性2016
- Author(s)
  岡村信行、原田龍一
- Organizer
  第35回日本認知症学会学術集会
- Place of Presentation
  東京国際フォーラム（東京都千代田区）
- Year and Date
  2016-12-02
- Data Source
  KAKENHI-PROJECT-15H04900
[Presentation] Assessment of tau pathology in patients with corticobasal syndrome using 18F-THK5351 PET2016
- Author(s)
  Kikuchi A, Okamura N, Hasegawa T, Harada R, Watanuki S, Funaki Y, Hiraoka K, Toru Baba, Naoto Sugeno, Ryuji Oshima, Shun Yoshida, Junpei Kobayashi, Ezura M, Kobayashi M, Tano O, Mugikura S, Iwata R, Ishiki A, Furukawa K, Arai H, Furumoto S, Tashiro M, Yanai K, Kudo Y, Takeda A, Aoki M
- Organizer
  The Movement Disorder Society's 20th International Congress of Parkinson's Disease and Movement Disorders
- Place of Presentation
  Berlin, Germany
- Year and Date
  2016-06-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461303
[Presentation] [F-18]THK5351 retention is associated with the progression of brain atrophy in patients with Alzheimer's disease.2016
- Author(s)
  Okamura N, Ishiki A, Furukawa K, Harada R, Tomita N, Furumoto S, Tashiro M, Yanai K, Arai H, Kudo Y.
- Organizer
  AAIC 2016
- Place of Presentation
  Toronto, Canada
- Year and Date
  2016-07-22
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04900
[Presentation] 認知症におけるタウPETイメージング2016
- Author(s)
  岡村信行
- Organizer
  第12回認知症ファイヤーカンファレンス
- Place of Presentation
  愛知県産業労働センター（愛知県名古屋市）
- Year and Date
  2016-06-18
- Invited
- Data Source
  KAKENHI-PROJECT-15H04900
[Presentation] パーキンソン病患者での[11C]BF-227 PETによるα-シヌクレイン蛋白凝集体の画像化2016
- Author(s)
  菊池昭夫、岡村信行、馬場徹、長谷川隆文、菅野直人、大嶋龍司、吉田隼、小林潤平、平岡宏太良、古本祥三、谷内一彦、田代学、工藤幸司、武田篤、青木正志
- Organizer
  第57回日本神経学会学術大会
- Place of Presentation
  神戸、神戸コンベンションセンター・神戸ポートピアホテル
- Year and Date
  2016-05-18
- Data Source
  KAKENHI-PROJECT-26461303
[Presentation] Tau PET Imaging. Current status and future directions.2016
- Author(s)
  Okamura N
- Organizer
  Mind Brain Conference "From Molecules to the Universe: Advancing Biomedical Sciences and Engineering"
- Place of Presentation
  グランドホテル浜松（静岡県浜松市）
- Year and Date
  2016-02-24
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04900
[Presentation] Impact of tau PET on dementia research.2016
- Author(s)
  岡村信行
- Organizer
  第56回日本核医学会学術総会
- Place of Presentation
  名古屋国際会議場（愛知県名古屋市）
- Year and Date
  2016-11-05
- Invited
- Data Source
  KAKENHI-PROJECT-15H04900
[Presentation] Tau imaging.2016
- Author(s)
  Okamura N
- Organizer
  AONeuro Symposium - Neurotrauma
- Place of Presentation
  仙台市立病院（宮城県仙台市）
- Year and Date
  2016-02-28
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04900
[Presentation] アルツハイマー病のPET診断2016
- Author(s)
  岡村信行
- Organizer
  第11回日本分子イメージング学会総会・学術集会
- Place of Presentation
  神戸国際会議場（兵庫県神戸市）
- Year and Date
  2016-05-28
- Data Source
  KAKENHI-PROJECT-15H04900
[Presentation] タウPETイメージング：最近の進歩2016
- Author(s)
  岡村信行
- Organizer
  AAJ関東甲信越エリアシンポジウム
- Place of Presentation
  大手町サンケイプラザ（東京都千代田区）
- Year and Date
  2016-07-03
- Invited
- Data Source
  KAKENHI-PROJECT-15H04900
[Presentation] アルツハイマー病の分子イメージング2016
- Author(s)
  岡村信行、長沼史登、中村正帆
- Organizer
  第32回日本DDS学会学術集会
- Place of Presentation
  静岡県コンベンションアーツセンター（静岡市駿河区）
- Year and Date
  2016-06-30
- Invited
- Data Source
  KAKENHI-PROJECT-15H04900
[Presentation] 認知症患者における神経原線維変化の画像化に関する研究2016
- Author(s)
  岡村信行
- Organizer
  第35回日本認知症学会学術集会
- Place of Presentation
  東京国際フォーラム（東京都千代田区）
- Year and Date
  2016-12-01
- Data Source
  KAKENHI-PROJECT-15H04900
[Presentation] Distinct patterns of [18F]THK-5351 retention in AD and non-AD tauopathies.2016
- Author(s)
  Okamura N, Kikuchi A, Furukawa K, Ishiki A, Harada R, Hasegawa T, Takeda A, Furumoto S, Iwata R, Tashiro M, Yanai K, Aoki M, Arai H, Kudo Y.
- Organizer
  The 10th Human Amyloid Imaging (HAI) meeting
- Place of Presentation
  Miami (USA)
- Year and Date
  2016-01-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04900
[Presentation] タウイメージングトレーサー[18F]THK-5351 の代謝解析2015
- Author(s)
  原田龍一，岡村信行，古本祥三，多胡哲郎，岩田錬，谷内一彦，工藤幸司
- Organizer
  第 55 回日本核医学会学術総会
- Place of Presentation
  東京
- Year and Date
  2015-11-05
- Data Source
  KAKENHI-PROJECT-25293259
[Presentation] Recent experiences with THK compounds.2015
- Author(s)
  Okamura N
- Organizer
  ADPD 2015
- Place of Presentation
  Nice, France
- Year and Date
  2015-03-17
- Invited
- Data Source
  KAKENHI-PROJECT-25670524
[Presentation] 2-アリールキノリン PET タウイメージング剤の構造活性相関研究2015
- Author(s)
  多胡哲郎，古本祥三，岡村信行，原田龍一，石川洋一，谷内一彦，岩田錬，工藤幸司
- Organizer
  日本分子イメージング学会第 10 回総会・学術集会
- Place of Presentation
  東京
- Year and Date
  2015-05-20
- Data Source
  KAKENHI-PROJECT-25293259
[Presentation] [11C]BF-227 PETにおける多系統萎縮症脳内α-シヌクレインの経時的変化2015
- Author(s)
  菊池昭夫、岡村信行、馬場徹、長谷川隆文、菅野直人、今野昌俊、三浦永美子、大嶋龍司、吉田隼、古本祥三、平岡宏太良、谷内一彦、田代学、工藤幸司、糸山泰人、武田篤、青木正志.
- Organizer
  第56回日本神経学会学術大会
- Place of Presentation
  朱鷺メッセ (新潟)
- Year and Date
  2015-05-20
- Data Source
  KAKENHI-PROJECT-26461303
[Presentation] Longitudinal [11C]BF-227 PET study in MSA-C patients2015
- Author(s)
  Kikuchi A, Okamura N, Tashiro M, Furumoto S, Hasegawa T, Watanuki S, Hiraoka K, Funaki Y, Kobayashi M, Sugeno N, Baba T, Konno M, Miura E, Oshima R, Yoshida S, Iwata R, Takahashi S, Fukuda H, Itoyama Y, Arai H, Kudo Y, Yanai K, Aoki M, Takeda A.
- Organizer
  19th International Congress of Parkinson's Disease and Movement Disorders
- Place of Presentation
  San Diego, USA
- Year and Date
  2015-06-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461303
[Presentation] PETによるアルツハイマー病タウイメージングのための2-アリールキノリン誘導体開発2015
- Author(s)
  多胡哲郎，古本祥三，岡村信行，原田龍一，安立創，石川洋一，谷内一彦，工藤幸司，岩田錬
- Organizer
  第 55 回日本核医学会学術総会
- Place of Presentation
  東京
- Year and Date
  2015-11-05
- Data Source
  KAKENHI-PROJECT-25293259
[Presentation] Tau imaging in dementia.2015
- Author(s)
  Okamura N
- Organizer
  Molecular Imaging of Dementia: Beyond Amyloid PET
- Place of Presentation
  Baltimore (USA)
- Year and Date
  2015-06-06
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04900
[Presentation] Preclinical characterization of [18F]THK-5117 enantiomers as a PET tau probe for tau pathology in Alzheimer’s disease2015
- Author(s)
  T. Tago, S. Furumoto, N. Okamura, R. Harada, H. Adachi, Y. Ishikawa, K. Yanai, R. Iwata, Y. Kudo.
- Organizer
  21st International Symposium on Radiopharmaceutical Sciences
- Place of Presentation
  Columbia, Missouri
- Year and Date
  2015-05-26
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293259
[Presentation] Tau PET imaging with THK tau tracers.2015
- Author(s)
  Okamura N.
- Organizer
  2015 IPA 17th International Congress
- Place of Presentation
  Berlin (Germany)
- Year and Date
  2015-10-15
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04900
[Presentation] Experience with Tau PET.2015
- Author(s)
  Okamura N
- Organizer
  Busan Paik Hospital Neurodegenerative Disease Symposium
- Place of Presentation
  Busan (South Korea)
- Year and Date
  2015-11-27
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04900
[Presentation] Distribution of tau pathology in the patients with mild cognitive impairment and Alzheimer’s disease measured with [18F]THK-5351 PET.2015
- Author(s)
  Okamura N, Furumoto S, Furukawa K, Ishiki A, Tomita N, Harada R, Tashiro M, Yanai K, Arai H, Kudo Y.
- Organizer
  AAIC 2015
- Place of Presentation
  Washington D.C. (USA)
- Year and Date
  2015-07-22
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04900
[Presentation] PET imaging of tau pathology in mild cognitive impairment and Alzheimer's disease with [18F]THK-5351.2015
- Author(s)
  Okamura N, Furumoto S, Furukawa K, Ishiki A, Harada R, Iwata R, Tashiro M, Yanai K, Arai H, Kudo Y.
- Organizer
  SNMMI 2015 Annual Meeting
- Place of Presentation
  Baltimore (USA)
- Year and Date
  2015-06-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04900
[Presentation] PET imaging of tau deposits in Alzheimer's disease patients using 18F-THK5105 and 18F-THK5117.2014
- Author(s)
  Okamura N, Furumoto S, Harada R, Furukawa K, Ishiki A, Fodero-Tavoletti MT, Mulligan RS, Iwata R, Tashiro M, Yanai K, Masters CL, Arai H, Rowe CC, Villemagne VL, Kudo Y.
- Organizer
  Human Amyloid Imaging 2014
- Place of Presentation
  Miami, USA
- Data Source
  KAKENHI-PROJECT-25670524
[Presentation] Tau PET imaging in Alzheimer ' s disease using novel 2-phenylquinoline derivatives2014
- Author(s)
  Okamura N
- Organizer
  The Fifteenth Conference of Peace through Mind Brain Science
- Place of Presentation
  Hamamatsu
- Year and Date
  2014-02-19
- Data Source
  KAKENHI-PROJECT-23390297
[Presentation] Tau PET imaging in Alzheimer’s disease using novel 2-phenylquinoline derivatives.2014
- Author(s)
  Okamura N.
- Organizer
  The Fifteenth Conference of Peace through Mind Brain Science
- Place of Presentation
  浜松
- Invited
- Data Source
  KAKENHI-PROJECT-23390297
[Presentation] Tau PET imaging in Alzheimer’s disease using novel 2-phenylquinoline derivatives.2014
- Author(s)
  Okamura N
- Organizer
  The Fifteenth Conference of Peace through Mind Brain Science
- Place of Presentation
  浜松
- Invited
- Data Source
  KAKENHI-PROJECT-25670524
[Presentation] PET imaging of tau deposits in Alzheimer's disease patients using ^<18>F-THK5105 and ^<18>F-THK51172014
- Author(s)
 Okamura N, Furumoto S, Harada R, Furukawa K, Ishiki A, Fodero-Tavoletti MT , Mulligan RS, Iwata R, Tashiro M, Y anai K, Masters CL, Arai H, Rowe CC, Villemagne VL, Kudo Y
- Organizer
 Human Amyloid Imaging 2014
- Place of Presentation
 Miami, USA
- Year and Date
 2014-01-16
- Data Source
 KAKENHI-PROJECT-23390297
[Presentation] PET tau imaging in Alzheimer’s disease using 18F-THK5105 and 18F-THK5117.2014
- Author(s)
  Okamura N, Harada R, Furumoto S, Yanai K, Arai H, Kudo Y.
- Organizer
  The 87th Annual Meeting of The Japanese Pharmacological Society
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-25670524
[Presentation] Tau and Amyloid Imaging. Outlook for the Future.2014
- Author(s)
  Okamura N.
- Organizer
  EANM 2014
- Place of Presentation
  Gothenburg, Sweden
- Year and Date
  2014-10-21
- Invited
- Data Source
  KAKENHI-PROJECT-25670524
[Presentation] PET imaging of tau deposits in Alzheimer's disease patients using 18F-THK5105 and 18F-THK5117.2014
- Author(s)
  Okamura N, Furumoto S, Harada R, Furukawa K, Ishiki A, Fodero-Tavoletti MT, Mulligan RS, Iwata R, Tashiro M, Yanai K, Masters CL, Arai H, Rowe CC, Villemagne VL, Kudo Y.
- Organizer
  Human Amyloid Imaging 2014
- Place of Presentation
  Miami, USA
- Data Source
  KAKENHI-PROJECT-23390297
[Presentation] PET tau imaging in Alzheimer’s disease using 18F-THK5105 and 18F-THK5117.2014
- Author(s)
  Okamura N, Harada R, Furumoto S, Yanai K, Arai H, Kudo Y.
- Organizer
  The 87th Annual Meeting of The Japanese Pharmacological Society
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-23390297
[Presentation] Imaging neurofibrillary pathology in Alzheimer’s disease using novel tau PET tracer.2014
- Author(s)
  Okamura N.
- Organizer
  14th ICGP & 19th JSNP Joint Congress
- Place of Presentation
  つくば国際会議場（つくば市）
- Year and Date
  2014-10-03
- Invited
- Data Source
  KAKENHI-PROJECT-25670524
[Presentation] Advances in Tau PET.2014
- Author(s)
  Okamura N.
- Organizer
  SNMMI 2014 Annual Meeting
- Place of Presentation
  St. Louis, USA
- Year and Date
  2014-06-08
- Invited
- Data Source
  KAKENHI-PROJECT-25670524
[Presentation] Tau-Imaging. Results of First-in Human Studies.2014
- Author(s)
  Okamura N.
- Organizer
  EANM 2014
- Place of Presentation
  Gothenburg, Sweden
- Year and Date
  2014-10-18
- Invited
- Data Source
  KAKENHI-PROJECT-25670524
[Presentation] PET imaging of tau pathology in patients with Alzheimer's disease using 18F-THK5117.2013
- Author(s)
  Okamura N, Furumoto S, Harada R, Furukawa K, Ishiki A, Tomita N, Iwata R, Tashiro M, Yanai K, Arai H, Kudo Y.
- Organizer
  Clinical Trials on Alzheimer's Disease 2013
- Place of Presentation
  San Diego, USA
- Data Source
  KAKENHI-PROJECT-25670524
[Presentation] PET tau imaging in Alzheimer's disease using novel ^<18>F-labeled 2-phenylquinoline derivatives2013
- Author(s)
 Okamura N, Furumoto S, Harada R, Fodero-Tavoletti MT , Mulligan RS, Masters CL, Y anai K, Kudo Y , Rowe CC, Villemagne VL
- Organizer
 SNMMI Annual Meeting
- Place of Presentation
 Vancouver , Canada
- Year and Date
 2013-06-11
- Data Source
 KAKENHI-PROJECT-23390297
[Presentation] [18F]THK-5105 and [18F]THK-5117 as possible PET probes for in vivo detection of tau pathology in Alzheimer’s disease.2013
- Author(s)
  Okamura et al.
- Organizer
  7th Human Amyloid Imaging meeting
- Place of Presentation
  Miami Beach, USA
- Data Source
  KAKENHI-PROJECT-23390297
[Presentation] In vivo detection of tau protein deposits in Alzheimer's disease using ^<18>F-labeled 2-phenylquinoline derivatives2013
- Author(s)
 Okamura N, Furumoto S, Harada R, Fodero-Tavoletti MT , Mulligan RS, Masters CL, Y anai K, Kudo Y , Rowe CC, Villemagne VL
- Organizer
 Alzheimer ' s Association International Conference 2013
- Place of Presentation
 Boston, USA
- Data Source
 KAKENHI-PROJECT-23390297
[Presentation] PET tau imaging in Alzheimer's disease using novel 18F-labeled 2-phenylquinoline derivatives.2013
- Author(s)
  Okamura N, Furumoto S, Harada R, Fodero-Tavoletti MT, Mulligan RS, Masters CL, Yanai K, Kudo Y, Rowe CC, Villemagne VL.
- Organizer
  SNMMI Annual Meeting
- Place of Presentation
  Vancouver, Canada
- Data Source
  KAKENHI-PROJECT-25670524
[Presentation] [18F]THK-5105を用いたアルツハイマー病脳内タウ蛋白のPETイメージング2013
- Author(s)
  岡村信行、古本祥三、原田龍一、多胡哲郎、岩田錬、谷内一彦、工藤幸司、Michelle T Fodero-Tavoletti、Christopher C Rowe、Victor L. Villemagne.
- Organizer
  第8回日本分子イメージング学会総会・学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23390297
[Presentation] In vivo tau imaging in Alzheimer's disease using [18F]THK-5105.2013
- Author(s)
  Okamura et al.
- Organizer
  The 11th International Conference on Alzheimer's & Parkinson's diseases.
- Place of Presentation
  Firenze, Italy
- Data Source
  KAKENHI-PROJECT-23390297
[Presentation] PET imaging of tau pathology in patients with Alzheimer's disease using ^<18>F-THK51172013
- Author(s)
 Okamura N, Furumoto S, Harada R, Furukawa K, Ishiki A, T omita N, Iwata R, Tashiro M, Y anai K, Arai H, Kudo Y
- Organizer
 Clinical Trials on Alzheimer's Disease (CtaD) 2013
- Place of Presentation
 San Diego, USA
- Year and Date
 2013-11-14
- Data Source
 KAKENHI-PROJECT-23390297
[Presentation] アルツハイマー病患者における[18F]THK-5105, [18F]THK-5117の臨床評価．2013
- Author(s)
  岡村信行、古本祥三、原田龍一、多胡哲郎、古川勝敏、石木愛子、冨田尚希、平岡宏太良、四月朔日聖一、松田林、石川洋一、田代学、岩田錬、谷内一彦、荒井啓行、工藤幸司、Rachel S Mulligan、Christopher C Rowe、Victor L Villemagne．
- Organizer
  第53回日本核医学会学術総会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23390297
[Presentation] In vivo pattern of tau and Aβ deposition in the brain might distinguish healthy controls from preclinical Alzheimer's disease.2013
- Author(s)
  Villemagne VL Furumoto S, Fodero-Tavoletti MT, Mulligan RS, Harada R, Yates P, Pejoska S, Kudo Y, Masters CL, Yanai K, Rowe CC, Okamura N.
- Organizer
  Alzheimer’s Association International Conference(AAIC) 2013
- Place of Presentation
  Boston, USA
- Data Source
  KAKENHI-PROJECT-23390297
[Presentation] In vivo detection of tau protein deposits in Alzheimer's disease using 18F-labeled 2-phenylquinoline derivatives.2013
- Author(s)
  Okamura N, Furumoto S, Harada R, Fodero-Tavoletti MT, Mulligan RS, Masters CL, Yanai K, Kudo Y, Rowe CC, Villemagne VL.
- Organizer
  Alzheimer’s Association International Conference(AAIC) 2013
- Place of Presentation
  Boston, USA
- Data Source
  KAKENHI-PROJECT-23390297
[Presentation] PET tau imaging in Alzheimer's disease using novel 18F-labeled 2-phenylquinoline derivatives.2013
- Author(s)
  Okamura N, Furumoto S, Harada R, Fodero-Tavoletti MT, Mulligan RS, Masters CL, Yanai K, Kudo Y, Rowe CC, Villemagne VL.
- Organizer
  SNMMI Annual Meeting
- Place of Presentation
  Vancouver, Canada
- Data Source
  KAKENHI-PROJECT-23390297
[Presentation] Imaging tau pathology in Alzheimer's disease using 18F-THK5105 and 18F-THK5117 PET2013
- Author(s)
  Okamura N
- Organizer
  ADNI PPSB meeting
- Place of Presentation
  Washington DC, USA
- Invited
- Data Source
  KAKENHI-PROJECT-25670524
[Presentation] アルツハイマー病患者における[18F]THK5105の臨床評価2013
- Author(s)
  岡村信行、古本祥三、原田龍一、多胡哲朗、谷内一彦、レイチェルマリガン、クリストファーロウ、ビクタービルマーニ
- Organizer
  第53回日本核医学会学術総会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-25293259
[Presentation] [18F]THK-5105 PETを用いたアルツハイマー病タウ病理像の生体画像化2013
- Author(s)
  岡村信行、古本祥三、原田龍一、古川勝敏、石木愛子、冨田尚希、荒井啓行、谷内一彦、工藤幸司、Rachel S Mulligan、Christopher C Rowe、Victor L Villemagne．
- Organizer
  第32回日本認知症学会学術集会
- Place of Presentation
  松本
- Data Source
  KAKENHI-PROJECT-23390297
[Presentation] PET用タウイメージング剤[18F]THK5105のエナンチオマー体の合成と評価2013
- Author(s)
  多胡哲朗、古本祥三、岡村信行、原田龍一、石川洋一、谷内一彦、工藤幸司、岩田錬
- Organizer
  第53回日本核医学会学術総会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-25293259
[Presentation] PET imaging of tau pathology in patients with Alzheimer's disease using 18F-THK5117.2013
- Author(s)
  Okamura N, Furumoto S, Harada R, Furukawa K, Ishiki A, Tomita N, Iwata R, Tashiro M, Yanai K, Arai H, Kudo Y.
- Organizer
  Clinical Trials on Alzheimer's Disease (CtaD) 2013
- Place of Presentation
  San Diego, USA
- Data Source
  KAKENHI-PROJECT-23390297
[Presentation] Imaging tau pathology in Alzheimer's disease using 18F-THK5105 and 18F-THK5117 PET.2013
- Author(s)
  Okamura N.
- Organizer
  ADNI PPSB meeting
- Place of Presentation
  Washington DC, USA
- Invited
- Data Source
  KAKENHI-PROJECT-23390297
[Presentation] [^<18>F]THK-5105 and [^<18>F]THK-5117 as possible PET probes for in vivo detection of tau pathology in Alzheimer ' s disease2013
- Author(s)
 Okamura N, Furumoto S, Harada R, Tago T , Fodero-Tavoletti M, Villemagne VL, Iwata R, Arai H, Y anai K, Kudo Y
- Organizer
 7th Human Amyloid Imaging meeting
- Place of Presentation
 Miami, USA
- Data Source
 KAKENHI-PROJECT-23390297
[Presentation] Imaging prion and other misfolded protein deposits using PET.2013
- Author(s)
  Okamura N
- Organizer
  Asia Pacific Prion Symposium
- Place of Presentation
  長崎
- Invited
- Data Source
  KAKENHI-PROJECT-25670524
[Presentation] In vivo detection of tau protein deposits in Alzheimer's disease using 18F-labeled 2-phenylquinoline derivatives.2013
- Author(s)
  Okamura N, Furumoto S, Harada R, Fodero-Tavoletti MT, Mulligan RS, Masters CL, Yanai K, Kudo Y, Rowe CC, Villemagne VL.
- Organizer
  Alzheimer’s Association International Conference(AAIC) 2013
- Place of Presentation
  Boston, USA
- Data Source
  KAKENHI-PROJECT-25670524
[Presentation] Imaging prion and other misfolded protein deposits using PET.2013
- Author(s)
  Okamura N.
- Organizer
  Asia Pacific Prion Symposium (APPS)
- Place of Presentation
  長崎
- Invited
- Data Source
  KAKENHI-PROJECT-23390297
[Presentation] In vivo tau imaging in Alzheimer's disease using [^<18>F]THK-51052013
- Author(s)
 Okamura N, Furumoto S, Harada R, Fodero-Tavoletti MT , Mulligan RS, Masters CL, Y anai K, Kudo Y , Rowe CC, Villemagne VL
- Organizer
 AD/PD The 11th International Conference on Alzheimer's & Parkinson's diseases
- Place of Presentation
 Firenze, Italy
- Data Source
 KAKENHI-PROJECT-23390297
[Presentation] Imaging tau pathology in Alzheimer's disease using ^<18>F-THK5105 and ^<18>F-THK5117 PET2013
- Author(s)
 Okamura N
- Organizer
 ADNI PPSB meeting
- Place of Presentation
 Washington DC, USA
- Year and Date
 2013-10-26
- Data Source
 KAKENHI-PROJECT-23390297
[Presentation] Noninvasive assessment of drug binding site with positron emission tomography is useful in the prediction of the efficacy of cholinesterase inhibitor.2012
- Author(s)
  Okamura et al.
- Organizer
  SNM2012 annual meeting
- Place of Presentation
  Miami Beach, USA
- Data Source
  KAKENHI-PROJECT-23390297
[Presentation] Molecular imaging of disease-related pathology in neurodegenerative dementia2012
- Author(s)
  Okamura N
- Organizer
  The 11th Biennial Meeting of the Asian Pacific Society for Neurochemistry
- Place of Presentation
  Kobe
- Year and Date
  2012-10-02
- Data Source
  KAKENHI-PROJECT-23390297
[Presentation] PET tau imaging in Alzheimer ' s disease using ^<18>F-THK5105 and ^<18>F-THK51172012
- Author(s)
 Okamura N, Harada R, Furumoto S, Y anai K, Arai H, Kudo Y
- Organizer
 The 87th Annual Meeting of The Japanese Pharmacological Society
- Place of Presentation
 Sendai
- Year and Date
 2012-03-21
- Data Source
 KAKENHI-PROJECT-23390297
[Presentation] アルツハイマー病の病理画像化を目指したF-18標識PETプローブの開発2012
- Author(s)
  古本祥三、岡村信行、樋口真人、岩田錬、工藤幸司、谷内一彦
- Organizer
  第85回日本薬理学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-21390171
[Presentation] [^<11>C]BF-227 PET study in patients with dementia with Lewy bodies2012
- Author(s)
 Okamura N, Furukawa K, Tashiro M, Furumoto S, Harada R, Arai H, Iwata R, Kudo Y , Yanai K
- Organizer
 SNM2012 annual meeting
- Place of Presentation
 Miami, USA
- Data Source
 KAKENHI-PROJECT-23390297
[Presentation] Characterization of the binding properties of novel ^<18>F-labeled quinoline derivatives to amyloid and tau protein deposits in Alzheimer ' s disease2012
- Author(s)
 Okamura N, Furumoto S, Harada R, Tago T , Iwata R, Y anai K, Kudo Y
- Organizer
 The 25th Annual Congress of the European Association of Nuclear Medicine
- Place of Presentation
 Milan, Italy
- Year and Date
 2012-10-29
- Data Source
 KAKENHI-PROJECT-23390297
[Presentation] アルツハイマー病におけるタウ蛋白画像化の試み2012
- Author(s)
  岡村信行
- Organizer
  第26回老年期認知症研究会
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-23390297
[Presentation] Development of novel tau-specific imaging probes.2012
- Author(s)
  Okamura N.
- Organizer
  International Symposium of Tohoku University Molecular Imaging Educational Course
- Place of Presentation
  Sendai, Japan
- Invited
- Data Source
  KAKENHI-PROJECT-23390297
[Presentation] 受容体遮断は睡眠除去した野生型とH1受容体遺伝子ノックアウトマウスで自発運動量を増加させる2012
- Author(s)
  アタイエフモーセン、長沼史登、渋谷勝彦、中村正帆、吉川雄朗、岡村信行、谷内一彦
- Organizer
  第85回日本薬理学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-21390171
[Presentation] アルツハイマー病患者における脳内アセチルコリンエステラーゼへの[^<11>C]ドネペジル結合量と塩酸ドネペジル治療反応性との関連性2012
- Author(s)
 岡村信行、糟谷昌志, 他
- Organizer
 第85回日本薬理学会年会
- Place of Presentation
 京都
- Year and Date
 2012-03-16
- Data Source
 KAKENHI-PROJECT-23390297
[Presentation] [18F] THK-523によるin vivoタウイメージング2012
- Author(s)
  原田龍一、岡村信行、古本祥三、吉川雄朗、荒井啓行、谷内一彦、工藤幸司
- Organizer
  第85回日本薬理学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-21390171
[Presentation] Characterization of the binding properties of novel 18F-labeled quinoline derivatives to amyloid and tau protein deposits in Alzheimer’s disease.2012
- Author(s)
  Okamura et al.
- Organizer
  The 25th Annual Congress of the European Association of Nuclear Medicine
- Place of Presentation
  Milan, Italy
- Data Source
  KAKENHI-PROJECT-23390297
[Presentation] PET分子イメージングによる認知症早期診断2012
- Author(s)
  岡村信行
- Organizer
  第30回画像診断の基礎と臨床学術講演会
- Place of Presentation
  鴨川
- Year and Date
  2012-03-24
- Data Source
  KAKENHI-PROJECT-23390297
[Presentation] Imaging amyloid and tau pathology in Alzheimer's disease brain2012
- Author(s)
  Okamura N
- Organizer
  JSPS-NRF Asian Science Seminar
- Place of Presentation
  ソウル、韓国
- Year and Date
  2012-02-17
- Data Source
  KAKENHI-PROJECT-23390297
[Presentation] Novel 18F-labeled quinoline derivatives for in vivo detection of tau pathology in Alzheimer’s disease.2012
- Author(s)
  Okamura et al.
- Organizer
  Alzheimer’s Association International Conference(AAIC) 2012
- Place of Presentation
  Vancouver, Canada
- Data Source
  KAKENHI-PROJECT-23390297
[Presentation] Development of novel tau-specific imaging probes2012
- Author(s)
  Okamura N
- Organizer
  International Symposium of T ohoku University Molecular Imaging Educational Course
- Place of Presentation
  Sendai
- Year and Date
  2012-10-04
- Data Source
  KAKENHI-PROJECT-23390297
[Presentation] Molecular imaging of disease-related pathology in neurodegenerative dementia.2012
- Author(s)
  Okamura N.
- Organizer
  The 11th Biennial Meeting of the Asian Pacific Society for Neurochemistry
- Place of Presentation
  Kobe, Japan
- Invited
- Data Source
  KAKENHI-PROJECT-23390297
[Presentation] Imaging amyloid and tau pathology in Alzheimer ' s disease brain2012
- Author(s)
  Okamura N
- Organizer
  JSPS-NRF Asian Science Seminar
- Place of Presentation
  Seoul, Korea
- Year and Date
  2012-02-17
- Data Source
  KAKENHI-PROJECT-23390297
[Presentation] Cholinergic deficit and response to donepezil therapy in Parkinson's disease with dementia2012
- Author(s)
  Kotaro Hiraoka, Nobuyuki Okamura, Yoshihito Funaki, Akiko Hayashi, Manabu Tashiro, Kinya Hisanaga, Toshikatsu Fujii, Atsushi Takeda, Kazuhiko Yanai, Ren Iwata, and Etsuro Mori
- Organizer
  SPS-NRF Asian Science Seminar
- Place of Presentation
  ソウル韓国
- Data Source
  KAKENHI-PROJECT-21390171
[Presentation] Novel 18F-labeled quinoline derivatives for in vivo detection of tau pathology in Alzheimer ' s disease2012
- Author(s)
  Okamura N, Furumoto S, Harada R, Fodero-Tavoletti M, Villemagne VL, Iwata R, Y anai K, Kudo Y
- Organizer
  Alzheimer's Association International Conference 2012
- Place of Presentation
  Vancouver , Canada
- Data Source
  KAKENHI-PROJECT-23390297
[Presentation] アルツハイマー病患者における脳内アセチルコリンエステラーゼへの[11C] ドネぺジル結合量と塩酸ドネぺジル治療反応性との関連性2012
- Author(s)
  岡村信行、糟谷昌志、石川博康、田中尚文、船木善仁、岩田錬、目黒謙一、谷内一彦
- Organizer
  第85回日本薬理学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-21390171
[Presentation] Wavelength-dependent detection of senile plaques and neurofibrillary tangles with novel fluorescent probes2012
- Author(s)
  Ryuichi Harada, Nobuyuki Okamura, Shozo Furumoto, Takeo Yoshikawa, Yukitsuka Kudo, Kazuhiko Yanai
- Organizer
  JSPS-NRF Asian Science Seminar
- Place of Presentation
  ソウル韓国
- Data Source
  KAKENHI-PROJECT-21390171
[Presentation] Potential Central Sedative Effects of Antihistamine Eye-drops : Histamine H1 Receptor Occupancy by PET2012
- Author(s)
  Dongying Zhang, Manabu Tashiro, Nobuyuki Okamura, and Kazuhiko Yanai
- Organizer
  第32回日本臨床薬理学会
- Place of Presentation
  浜松
- Data Source
  KAKENHI-PROJECT-21390171
[Presentation] The Distribution Change of Trace Metal in Methamphetamine Treated Mice Brain Slices by In-Air Micro-PIXE JSPS-NRF Asian Science Seminar2012
- Author(s)
  Eiko Sakurai, Keizo Ishii, Takahiro Satoh, Tomohiro Kamiya, Nobuyuki Okamura, Kazuhiko Yanai
- Place of Presentation
  ソウル韓国
- Data Source
  KAKENHI-PROJECT-21390171
[Presentation] Histamine H3 receptors antagonists increase anxiogenic-like behaviors and locomotor activity2011
- Author(s)
  Attayef Mohsen, Fumito Naganuma, Tadaho Nakamura, Katsuhiko Shibuya, Takeo Yoshikawa, Nobuyuki Okamura, and Kazuhiko Yanai
- Organizer
  第62回日本薬理学会北部会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-21390171
[Presentation] Noninvasive assessment of drug binding site with positron emission tomography is useful in the prediction of the efficacy of cholinesterase inhibitor2011
- Author(s)
  Okamura, et al
- Organizer
  4th Conference Clinical Trials on Alzheimer's Disease (CTAD)
- Place of Presentation
  サンディエゴ、米国
- Year and Date
  2011-11-03
- Data Source
  KAKENHI-PROJECT-23390297
[Presentation] Locomotor activity and anxiolytic-like behaviors are increased by histamine H3 receptor antagonists2011
- Author(s)
  ttayef Mohsen, Fumito Naganuma, Tadaho Nakamura, Katsuhiko Shibuya, Takeo Yoshikawa, Nobuyuki Okamura, and Kazuhiko Yanai
- Organizer
  第15回日本ヒスタミン学会
- Place of Presentation
  盛岡
- Data Source
  KAKENHI-PROJECT-21390171
[Presentation] Near-infrared fluorescence probe X50 for in vivo detection of amyloid plaques in the brain2011
- Author(s)
  Okamura N, Furumoto S, Harada R, Arai H, Y anai K, Kudo Y
- Organizer
  2011 International Conference on Alzheimer's Disease
- Place of Presentation
  Paris, France
- Year and Date
  2011-07-16
- Data Source
  KAKENHI-PROJECT-23390297
[Presentation] Phenylquinoline derivatives for in vivo imaging of tau pathology in Alzheimer ' s disease2011
- Author(s)
  Okamura N, Furumoto S, Harada R, Furukawa K, Arai H, Y anai K, Kudo Y
- Organizer
  2011 International Conference on Alzheimer's Disease
- Place of Presentation
  Paris, France
- Year and Date
  2011-07-20
- Data Source
  KAKENHI-PROJECT-23390297
[Presentation] タウイメージング用プローブの開発状況2011
- Author(s)
  岡村信行
- Organizer
  AD画像診断サブコミッティ
- Place of Presentation
  東京
- Year and Date
  2011-02-05
- Data Source
  KAKENHI-PROJECT-20591432
[Presentation] Noninvasive assessment of drug binding site with positron emission tomography is useful in the prediction of the efficacy of cholinesterase inhibitor2011
- Author(s)
  Okamura N, Kasuya M, Ishikawa H, Tanaka N, Funaki Y , Iwata R, Meguro K, Y anai K
- Organizer
  4th Conference Clinical Trials on Alzheimer's Disease
- Place of Presentation
  San Diego, USA
- Data Source
  KAKENHI-PROJECT-23390297
[Presentation] Molecular imaging of misfolded proteins2011
- Author(s)
  岡村信行、原田龍一, 他
- Organizer
  第34回日本神経科学大会
- Place of Presentation
  横浜
- Year and Date
  2011-09-17
- Data Source
  KAKENHI-PROJECT-23390297
[Presentation] αシヌクレイノパチーの画像バイオマーカーとしての[^<11>C]BF-227 PETの検討2011
- Author(s)
 岡村信行、古川勝敏, 他
- Organizer
 第32回日本臨床薬理学会学術総会
- Place of Presentation
 浜松
- Year and Date
 2011-12-01
- Data Source
 KAKENHI-PROJECT-23390297
[Presentation] 認知症早期診断のためのアミロイド・タウ分子イメージング2011
- Author(s)
  岡村信行
- Organizer
  第40回多摩核医学技術検討会
- Place of Presentation
  東京
- Year and Date
  2011-06-21
- Data Source
  KAKENHI-PROJECT-23390297
[Presentation] Phenylquinoline derivatives for in vivo imaging of tau pathology in Alzheimer's disease2011
- Author(s)
  Okamura, et al
- Organizer
  2011 International Conference on Alzheimer's Disease
- Place of Presentation
  パリ、フランス
- Year and Date
  2011-07-16
- Data Source
  KAKENHI-PROJECT-23390297
[Presentation] タウイメージング用プローブの候補化合物としてのTHK-951の検討2011
- Author(s)
  岡村信行、古本祥三, 他
- Organizer
  第51回日本核医学会学術総会
- Place of Presentation
  つくば
- Year and Date
  2011-10-29
- Data Source
  KAKENHI-PROJECT-23390297
[Presentation] Development of novel imaging probe for senile plaques and neurofibrillary tangles.2010
- Author(s)
  Okamura N, Kudo Y.
- Organizer
  International Symposium for Molecular Imaging Educational Course of Tohoku University
- Place of Presentation
  Sendai
- Year and Date
  2010-03-12
- Data Source
  KAKENHI-PROJECT-20591432
[Presentation] Noninvasive detection of amyloid deposits using near-infrared fluorescence probe X50 in mice.2010
- Author(s)
  Okamura N, Mori M, Furumoto S, Yanai K, Kudo Y.
- Organizer
  2010 World Molecular Imaging Congress
- Place of Presentation
  Kyoto
- Data Source
  KAKENHI-PROJECT-20591432
[Presentation] 軽度認知障害の進行予後予測のための画像バイオマーカーの比較検討2010
- Author(s)
  岡村信行、古川勝敏、藁谷正明、富田尚希、田代学、工藤幸司、荒井啓行、谷内一彦
- Organizer
  第31回日本臨床薬理学会年会
- Place of Presentation
  京都
- Year and Date
  2010-12-01
- Data Source
  KAKENHI-PROJECT-20591432
[Presentation] 認知症の分子イメージング.シンポジウム9.イメージングによる精神・神経疾患研究の新しい展開2010
- Author(s)
  岡村信行
- Organizer
  第20回日本臨床精神神経薬理学会・第40回日本神経精神薬理学会合同年会
- Place of Presentation
  仙台
- Year and Date
  2010-09-16
- Data Source
  KAKENHI-PROJECT-20591432
[Presentation] αシヌクレイノパチーにおける[^<11>C]BF-227PET 画像所見2010
- Author(s)
 岡村信行、菊池昭夫、武田篤、古本祥三、田代学、船木善仁、工藤幸司、岩田錬、谷内一彦
- Organizer
 第50回日本核医学会学術総会
- Place of Presentation
 大宮
- Year and Date
 2010-11-12
- Data Source
 KAKENHI-PROJECT-20591432
[Presentation] 蛋白ミスフォールディングの分子イメージング2010
- Author(s)
  岡村信行
- Organizer
  第8回脳核医学画像解析研究会
- Place of Presentation
  東京
- Year and Date
  2010-09-04
- Data Source
  KAKENHI-PROJECT-20591432
[Presentation] Measurement of Vesicular Monoamine Transporter Type 2 Density in Parkinson's Disease and Dementia with Lewy Bodies with [^<18>F]AV-133 PET.2010
- Author(s)
 Okamura N, Villemagne VL, Pejoska S, Mulligan RS, O'Keefe G, Jones G, Skovronsky D, Rowe CC.
- Organizer
 第50回日本核医学会学術総会
- Place of Presentation
 大宮
- Year and Date
 2010-11-11
- Data Source
 KAKENHI-PROJECT-20591432
[Presentation] Non-invasive detection of α-synuclein deposits in human brain using [^<11>C]BF227-PET.2009
- Author(s)
 Okamura N, Kikuchi A, Takeda A, Furumoto S, Furukawa K, Arai H, Fodero-Tavoletti MT, Villemagne VL, Itoyama Y, Yanai K, Kudo Y.
- Organizer
 2009 International Conference on Alzheimer's Disease (ICAD)
- Place of Presentation
 Vienna
- Year and Date
 2009-07-15
- Data Source
 KAKENHI-PROJECT-20591432
[Presentation] 認知症の分子イメージング2009
- Author(s)
  岡村信行
- Organizer
  第49回日本核医学会学術総会シンポジウム「脳疾患における分子イメージング」
- Place of Presentation
  旭川
- Year and Date
  2009-10-01
- Data Source
  KAKENHI-PROJECT-20591432
[Presentation] Molecular Imaging of acetylcholine esterase and amyloid deposits in Alzheimer disease2009
- Author(s)
  Yanai K, Okamura N.
- Organizer
  22th International Society of Neurochemistry (ISN/APSN2009)
- Place of Presentation
  プサン、韓国
- Data Source
  KAKENHI-PROJECT-21390171
[Presentation] ヒト脳内ヒスタミンH1受容体の男女差 : PET研究2009
- Author(s)
  加藤元久、田代学、吉沢正彦, 張冬頴, 岡村信行, 福土審, 谷内一彦
- Organizer
  第82回日本薬理学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19390061
[Presentation] アミロイドイメージングプローブ[^<18>F]FACTのアルツハイマー病早期診断における有用性の検討2009
- Author(s)
 岡村信行、古本祥三、田代学、古川勝敏、杉健太郎、荒井啓行、工藤幸司、谷内一彦
- Organizer
 第16回東北脳循環カンファランス
- Place of Presentation
 仙台
- Year and Date
 2009-11-28
- Data Source
 KAKENHI-PROJECT-20591432
[Presentation] PETを用いた脳アミロイドの画像化2009
- Author(s)
  岡村信行
- Organizer
  第50回日本神経学会総会
- Place of Presentation
  仙台国際センター(宮城県)
- Year and Date
  2009-05-22
- Data Source
  KAKENHI-PROJECT-20019006
[Presentation] PETを用いた脳アミロイドの画像化2009
- Author(s)
  岡村信行
- Organizer
  第50回日本神経学会総会シンポジウム「神経機能画像の進歩」
- Place of Presentation
  仙台
- Year and Date
  2009-05-22
- Data Source
  KAKENHI-PROJECT-20591432
[Presentation] PETを用いたアルツハイマー病の超早期診断法の確立と普及について2009
- Author(s)
  岡村信行
- Organizer
  第15回CYPRIS技術交流会
- Place of Presentation
  東京
- Year and Date
  2009-08-27
- Data Source
  KAKENHI-PROJECT-20591432
[Presentation] 脳神経疾患におけるバイオマーカー2009
- Author(s)
  岡村信行、谷内一彦
- Organizer
  第30回日本臨床薬理学会年会ワークショップ1「臨床試験とバイオマーカー」
- Place of Presentation
  横浜
- Year and Date
  2009-12-03
- Data Source
  KAKENHI-PROJECT-20591432
[Presentation] Molecular PET imaging in Alzheimer disease: From basic development to clinical application2009
- Author(s)
  Yanai K, Okamura N
- Organizer
  4th Japan-China Joint Meeting of Basic and Clinical Pharmacology
- Place of Presentation
  横浜
- Year and Date
  2009-03-18
- Data Source
  KAKENHI-PROJECT-19390061
[Presentation] [^<11>C]BF-227 PET Study in Protein Conformational Diseases.2009
- Author(s)
 Okamura N, Furumoto S, Tashiro M, Funaki Y, Kikuchi A, Shiga Y, Furukawa K, Arai H, Doh-ura K, Iwata R, Yanai K, Kudo Y.
- Organizer
 EANM'09 Annual Congress of the European Association of Nuclear Medicine
- Place of Presentation
 Barcelona
- Data Source
 KAKENHI-PROJECT-20591432
[Presentation] [^<11>C]BF-227 PET study of patients with protein misfolding diseases.2009
- Author(s)
 Okamura N, Furumoto S, Tashiro M, Furukawa K, Arai H, Doh-ura K, Kudo Y, Yanai K.
- Organizer
 The 2009 International Symposium on Early Detection and Rehabilitation Technology of Dementia-DRD2009
- Place of Presentation
 Okayama
- Year and Date
 2009-12-11
- Data Source
 KAKENHI-PROJECT-20591432
[Presentation] PETを用いた脳アミロイドの画像化2009
- Author(s)
  岡村信行
- Organizer
  第50回日本神経学会総会
- Place of Presentation
  仙台国際センター(宮城県)
- Year and Date
  2009-05-22
- Data Source
  KAKENHI-PROJECT-20591432
[Presentation] アミロイドイメージングの現状と展望2009
- Author(s)
  岡村信行
- Organizer
  第18回東北老年期認知症研究会
- Place of Presentation
  仙台
- Year and Date
  2009-11-14
- Data Source
  KAKENHI-PROJECT-20591432
[Presentation] PET imaging of brain amyloid deposits using BF-227 and its derivative2008
- Author(s)
  Okamura N, et.al.
- Organizer
  ICAD2008
- Place of Presentation
  Chicago, USA
- Year and Date
  2008-07-28
- Data Source
  KAKENHI-PROJECT-20591432
[Presentation] PET imaging of brain amyloid deposits using BF-227 and its derivative2008
- Author(s)
  Okamura N, et.al.
- Organizer
  ICAD 2008
- Place of Presentation
  Chicago, USA
- Year and Date
  2008-07-28
- Data Source
  KAKENHI-PROJECT-20019006
[Presentation] In vivo imaging of brain amyloid deposits using BF-227 and its derivative2008
- Author(s)
  Okamura N, et.al.
- Organizer
  SNM2008
- Place of Presentation
  New Orleans, USA
- Year and Date
  2008-06-15
- Data Source
  KAKENHI-PROJECT-20591432
[Presentation] Molecular PET imaging of acetylcholine esterase, histamine H1 receptor and amyloid deposits in Alzheimer disease2008
- Author(s)
  Okamura N, Yanai K
- Organizer
  13th International Conference on Biomedical Engineering(ICBME2008)
- Place of Presentation
  シンガポール
- Data Source
  KAKENHI-PROJECT-19390061
[Presentation] 和音の長調美・短調美に関与する脳内部位の検討2008
- Author(s)
  河地庸介, 鈴木美穂, 岡村信行, 田代学, 荒生弘史, 星芝貴行, 行場次朗, 谷内一彦
- Organizer
  東北大学電気通信研究所第351回音響工学研究会
- Place of Presentation
  仙台
- Year and Date
  2008-02-21
- Data Source
  KAKENHI-PROJECT-18650063
[Presentation] PET imaging of brain amyloid deposits using BF-227 and its derivative.2008
- Author(s)
  Okamura N, Furumoto S, Furukawa K, Tashiro M, Kato M, Mori M, Iwata R, Yanai K, Arai H, Kudo Y.
- Organizer
  Alzheimer's Association International Conference on Alzheimer's Disease 2008
- Place of Presentation
  Chicago, USA
- Data Source
  KAKENHI-PROJECT-20591432
[Presentation] Molecular PET imaging of acetylcholine esterase (AChE), histamine H1 receptor and amyloid deposits in Alzheimer disease.2008
- Author(s)
  Okamura N, Yanai K.
- Organizer
  The 13th International Conference on Biomedical Engineering (ICBME2008)
- Place of Presentation
  Singapore
- Data Source
  KAKENHI-PROJECT-20591432
[Presentation] 脳内ヒスタミン神経機能イメージング2008
- Author(s)
  谷内一彦, 岡村信行, 田代学
- Organizer
  第31回日本神経科学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19390061
[Presentation] ヒスタミン受容体遺伝子欠損がマウスの行動変化に及ぼす影響2008
- Author(s)
  櫻井映子, 倉増敦朗, 岡村信行, 谷内一彦
- Organizer
  第81回日本薬理学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19390061
[Presentation] In vivo imaging of brain amyloid deposits using BF-227 and its derivative2008
- Author(s)
  Okamura N, et. al.
- Organizer
  SNM2008
- Place of Presentation
  New Orleans, USA
- Year and Date
  2008-06-15
- Data Source
  KAKENHI-PROJECT-20019006
[Presentation] PET imaging of brain amyloid deposits using BF-227 and its derivative.2008
- Author(s)
  Okamura N, Furumoto S, Furukawa K, Tashiro M, Kato M, Mori M, Iwata R, Yanai K, Arai H, Kudo Y.
- Organizer
  Alzheimer's Imaging Consortium Pre-conference
- Place of Presentation
  Chicago, USA
- Year and Date
  2008-07-26
- Data Source
  KAKENHI-PROJECT-20591432
[Presentation] In vivo imaging of brain amyloid deposits using BF-227 and its derivative.2008
- Author(s)
  Okamura N, Furumoto S, Tashiro M, Kato M, Funaki Y, Furukawa K, Arai H, Iwata R, Yanai K, Kudo Y.
- Organizer
  SNM 2008 Annual Meeting
- Place of Presentation
  New Orleans, USA
- Data Source
  KAKENHI-PROJECT-20591432
[Presentation] Effect of histamine receptors gene knockout on behavioral changes in mice2008
- Author(s)
  E. Sakurai, A. Kuramasu, N. Okamura, K. Yanai
- Organizer
  第81回日本薬理学会年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2008-02-18
- Data Source
  KAKENHI-PROJECT-18500286
[Presentation] PET evaluation of sedative properties of antihistamines2008
- Author(s)
  K. Yanai, N. Okamura, M. Tashiro
- Organizer
  World Conference on Clinical Pharmacology and Therapeutics
- Place of Presentation
  カナダ・ケベック
- Data Source
  KAKENHI-PROJECT-19390061
[Presentation] PIXE分析の生体試料への応用-脳切片の微量元素の測定2007
- Author(s)
  櫻井映子、谷内一彦、岡村信行、石井慶造、酒巻学、山中健太郎、小山亮平、山崎浩道、松山成男、荒川和夫、神谷富裕、及川将一、佐藤隆博、芳賀潤二
- Organizer
  第2回先進科学技術に関する連携重点研究討論会
- Place of Presentation
  東海村
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18500286
[Presentation] Effect of histamine receptors gene knockout on behavioral changes in mice2007
- Author(s)
 Eiko Sakurai, Atsuo Kuramasu, Nobuyuki Okamura, Kazuhiko Yanai
- Organizer
 80^<th> Annual Meeting of the Japanese Pharmacological Society
- Year and Date
 2007-03-18
- Description
 「研究成果報告書概要(欧文)」より
- Data Source
 KAKENHI-PROJECT-18500286
[Presentation] Histamine receptors genes knockout mice and their phenotypes2007
- Author(s)
 Eiko Sakurai, He Shao, Atsuo Kuramasu, Nobuyuki Okamura, Kazuhiko Yanai
- Organizer
 50^<th> Annual Meeting of the Japanese Society for Neurochemistry
- Place of Presentation
 Yokohama
- Year and Date
 2007-09-10
- Description
 「研究成果報告書概要(欧文)」より
- Data Source
 KAKENHI-PROJECT-18500286
[Presentation] Histamine receptors genes knockout mice and their phenotypes2007
- Author(s)
  Eiko Sakurai, He Shao, Atsuo Kuramasu, Nobuyuki Okamura, Kazuhiko Yanai,
- Organizer
  第50回日本神経化学会・第30回日本神経科学会・第17回日本神経回路学会大会合同大会
- Place of Presentation
  横浜
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18500286
[Presentation] In vivo detection of amyloid deposits in Alzheimer's disease patients using [11C]BF-227 PET.2007
- Author(s)
  Okamura N, et. al.
- Organizer
  Brain'07
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-18019004
[Presentation] In vivo detection of amyloid deposits in Alzheimer's disease patients using [11C]BF-227 PET.2007
- Author(s)
  Okamura, et. al.
- Organizer
  Brain'07
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-18790865
[Presentation] Neural correlates of perceptual itching by histamine: a human fMRI study2007
- Author(s)
 Yanai K, Mochizuki H, Okamura N, Kato M, SakuraiE. Sadato N
- Organizer
 11^<th> Japanese histamine research society
- Place of Presentation
 Toyama
- Year and Date
 2007-12-14
- Description
 「研究成果報告書概要(欧文)」より
- Data Source
 KAKENHI-PROJECT-18500286
[Presentation] The effects of H1 receptor antagonists on cognitive dysfunction in socially-isolated mice2007
- Author(s)
  Eiko Sakurai, Feiyong Jia, Hongmei Dai, Motohisa Kato, Tomohiro Okuda, Atsuo Kuramasu, Nobuyuki Okamura, Takehiko Watanabe, Kazuhiko Yanai.
- Organizer
  第80回日本薬理学会年会
- Place of Presentation
  名古屋
- Year and Date
  2007-03-15
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18500286
[Presentation] ヒスタミンによる痒みの脳内メカニズム研究 : fMRI2007
- Author(s)
  谷内一彦, 望月秀紀, 岡村信行, 加藤元久, 櫻井映子, 定藤規弘
- Organizer
  第11回日本ヒスタミン学会
- Place of Presentation
  富山
- Data Source
  KAKENHI-PROJECT-19390061
[Presentation] Noninvasive detection of amyloid deposits in the patients with Alzheimer's disease using [11C]BF-227 PET.2007
- Author(s)
  Okamura N, et. al.
- Organizer
  IPA 2007
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-18019004
[Presentation] fMRIを用いたかゆみと痛みの違いに関する脳内メカニズム研究2007
- Author(s)
  谷内一彦、望月秀樹、岡村信行、加藤元久、櫻井映子、定籐規弘
- Organizer
  第58回日本薬理学会北部会
- Place of Presentation
  札幌
- Year and Date
  2007-09-29
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18500286
[Presentation] Eiko Sakurai. Feiyong Jia, Hongmei Dai, Motohisa Kato, Tomohiro Okuda, Atsuo Kuramasu, Nobuyuki Okamura, Takehiko Watanabe, Kazuhiko Yanai2007
- Author(s)
 Eiko Sakurai, Feiyong Jia, Hongmei Dai, Motohisa Kato, Tomohiro Okuda, Atsuo Kuramasu, Nobuyuki Okamura, Takehiko Watanabe, Kazuhiko Yanai
- Organizer
 80^<th> Annual Meeting of the Japanese Pharmacological Society
- Place of Presentation
 Nagoya
- Year and Date
 2007-03-15
- Description
 「研究成果報告書概要(欧文)」より
- Data Source
 KAKENHI-PROJECT-18500286
[Presentation] Effect of histamine receptors gene knockout on behavioral changes in mice.2007
- Author(s)
  Eiko Sakurai, Atsuo Kuramasu, Nobuyuki Okamura, Kazuhiko Yanai、
- Organizer
  第81回日本薬理学会年会
- Place of Presentation
  横浜
- Year and Date
  2007-03-18
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18500286
[Presentation] Histamine receptors genes knockout mice and their phenotypes2007
- Author(s)
  E. Sakurai, H. Shao, A. Kuramasu, N. Okamura, K. Yanai
- Organizer
  Neuro2007(第50回日本神経化学会)
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2007-09-10
- Data Source
  KAKENHI-PROJECT-18500286
[Presentation] C11-Donepezilを用いたアセチルコリンエステラーゼの分子イメージング2007
- Author(s)
  谷内一彦, 岡村信行, 加藤元久, 船木善仁, 荒井啓行, 目黒謙一, 岩田錬
- Organizer
  日本神経精神薬理学会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-19390061
[Presentation] Noninvasive detection of amyloid deposits in the patients with Alzheimer's disease using [11C]BF-227 PET.2007
- Author(s)
  Okamura, et. al.
- Organizer
  The 13th Congress of International Psychogeriatric Association.
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-18790865
[Presentation] Neural correlates of perceptual difference between itching and pain: a human fMRI study2007
- Author(s)
 Yanai K, Mochizuki H, Okamura N, Kato M, Sakurai E. Sadato N
- Organizer
 57^<th> Annual Meeting of the Japanese Pharmacological Society of hokubukai
- Place of Presentation
 Sapporo
- Year and Date
 2007-09-29
- Description
 「研究成果報告書概要(欧文)」より
- Data Source
 KAKENHI-PROJECT-18500286
[Presentation] ヒスタミンによる痒みの脳内メカニズム研究:fMRI研究2007
- Author(s)
  谷内一彦、望月秀樹、岡村信行、加藤元久、櫻井映子、定籐規弘
- Organizer
  第11回日本ヒスタミン学会
- Place of Presentation
  富山
- Year and Date
  2007-12-14
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18500286
[Presentation] 覚せい剤とストレスによる精神障害発現におけるヒスタミンH1受容体の役割2006
- Author(s)
  櫻井映子、賈飛勇、代紅梅、加藤元久、奥田友宏、倉増敦朗、岡村信行、渡邉建彦、谷内一彦
- Organizer
  第10回日本ヒスタミン研究会
- Place of Presentation
  岡山
- Year and Date
  2006-12-15
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18500286
[Presentation] Effect of HI receptors blockage on social isolation-induced behavioral changes2006
- Author(s)
 Eiko Sakurai, Feiyong Jia, Hongmei Dai, Motohisa Kate, Tomohiro, Okuda Atsuo Kuramasu, Nobuyuki Okamura, Takehiko Watanabe, . Kazuhiko Yanai
- Organizer
 49^<th> Annual Meeting of the Japanese Society for Neurochemistry
- Place of Presentation
 Nagoya
- Year and Date
 2006-09-16
- Description
 「研究成果報告書概要(欧文)」より
- Data Source
 KAKENHI-PROJECT-18500286
[Presentation] Effect of H1 receptors blockage on social isolation-induced behavioral changes2006
- Author(s)
  Eiko Sakurai, Feiyong Jia, Hongmei Dai, Motohisa Kato, Tomohiro Okuda, Atsuo Kuramasu, Nobuyuki Okamura, Takehiko Watanabe, Kazuhiko Yanai.
- Organizer
  第49回日本神経化学会、
- Place of Presentation
  名古屋
- Year and Date
  2006-09-16
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18500286
[Presentation] Eiko Sakurai. Feiyong Jia, Hongmei Dai, Motohisa Kato, Tomohiro Okuda, Atsuo Kuramasu, Nobuyuki Okamura, Takehiko Watanabe, Kazuhiko Yanai2006
- Author(s)
 Eiko Sakurai. Feiyong Jia, Hongmei Dai, Motohisa Kato, Tomohiro Okuda, Atsuo Kuramasu, Nobuyuki Okamura, Takehiko Watanabe, Kazuhiko Yanai
- Organizer
 10^<th> Japanese histamine research society
- Place of Presentation
 Okayama
- Year and Date
 2006-12-15
- Description
 「研究成果報告書概要(欧文)」より
- Data Source
 KAKENHI-PROJECT-18500286
[Presentation] [11C] BF-227 PET can visualize in vivo α-synuclein deposition in Parkinson’s disease.
- Author(s)
  Kikuchi A, Okamura N, Tashiro M, Hasegawa T, Sugeno N, Baba T, Konno M, Miura E, Oshima R, Furumoto S, Funaki Y, Iwata R, Takahashi S, Fukuda H, Arai H, Kudo Y, Yanai K, Aoki M, Itoyama Y, Takeda A.
- Organizer
  18th International Congress of Parkinson's Disease and Movement Disorders
- Place of Presentation
  Stockholm, Sweden
- Year and Date
  2014-06-08 – 2014-06-12
- Data Source
  KAKENHI-PROJECT-26461303
[Presentation] PET用タウイメージング剤[18F]THK-5105のエナンチオマー体の詳細評価
- Author(s)
  多胡哲郎, 古本祥三, 岡村信行, 原田龍一, 安立創, 石川洋一, 谷内一彦, 工藤幸司, 岩田錬
- Organizer
  第54回日本核医学会学術総会
- Place of Presentation
  大阪
- Year and Date
  2014-11-06 – 2014-11-08
- Data Source
  KAKENHI-PROJECT-25293259
[Presentation] Chirality of [18F]THK-5105 Affects its Preclinical Characteristics as a PET Tau Imaging Probe
- Author(s)
  Tago T, Furumoto S, Okamura N, Harada R, Adachi H, Ishikawa Y, Yanai K, Iwata R, Kudo Y
- Organizer
  9th Human Amyloid Imaging 2015
- Place of Presentation
  米国マイアミ
- Year and Date
  2015-01-14 – 2015-01-16
- Data Source
  KAKENHI-PROJECT-25293259
[Presentation] パーキンソン病における脳内α-シヌクレイン蛋白凝集体のPETによる画像化.
- Author(s)
  菊池昭夫、馬場徹、長谷川隆文、菅野直人、今野昌俊、三浦永美子、大嶋龍司、岡村信行、古本祥三、谷内一彦、田代学、工藤幸司、糸山泰人、武田篤、青木正志.
- Organizer
  第55回日本神経学会学術大会
- Place of Presentation
  福岡
- Year and Date
  2014-05-21 – 2014-05-24
- Data Source
  KAKENHI-PROJECT-26461303
[Presentation] パーキンソン病における脳内α-シヌクレイン蛋白凝集体のPETによる画像化.
- Author(s)
  菊池昭夫、馬場徹、長谷川隆文、菅野直人、今野昌俊、三浦永美子、大嶋龍司、岡村信行、古本祥三、谷内一彦、田代学、工藤幸司、糸山泰人、武田篤、青木正志.
- Organizer
  第55回日本神経学会学術大会
- Place of Presentation
  福岡
- Year and Date
  2014-05-21 – 2014-05-24
- Data Source
  KAKENHI-PROJECT-23591266
[Presentation] In vivo selective imaging of tau pathology in Alzheimer's disease with 18F-THK5117
- Author(s)
  Okamura N, Furumoto S, Harada R, Furukawa K, Ishiki A, Iwata R, Tashiro M, Yanai K, Arai H, Kudo Y.
- Organizer
  Society of Nuclear Medicine and Molecular Imaging 2014
- Place of Presentation
  米国セントルイス
- Year and Date
  2014-06-07 – 2014-06-11
- Data Source
  KAKENHI-PROJECT-25293259
[Presentation] PET用タウイメージング剤[18F]THK-5105エナンチオマー体の評価
- Author(s)
  多胡哲郎, 古本祥三, 岡村信行, 原田龍一, 安立創, 石川洋一, 谷内一彦, 工藤幸司, 岩田錬
- Organizer
  第9回日本分子イメージング学会総会・学術集会
- Place of Presentation
  大阪千里
- Year and Date
  2014-05-22 – 2014-05-23
- Data Source
  KAKENHI-PROJECT-25293259
[Presentation] [11C] BF-227 PET can visualize in vivo α-synuclein deposition in Parkinson’s disease.
- Author(s)
  Kikuchi A, Okamura N, Tashiro M, Hasegawa T, Sugeno N, Baba T, Konno M, Miura E, Oshima R, Furumoto S, Funaki Y, Iwata R, Takahashi S, Fukuda H, Arai H, Kudo Y, Yanai K, Aoki M, Itoyama Y, Takeda A.
- Organizer
  18th International Congress of Parkinson's Disease and Movement Disorders
- Place of Presentation
  Stockholm, Sweden
- Year and Date
  2014-06-08 – 2014-06-12
- Data Source
  KAKENHI-PROJECT-23591266
[Presentation] Accumulation of the novel tau imaging tracer, 18F-5117 is associated with brain atrophy in Alzheimer's disease.
- Author(s)
  Ishiki A, Furumoto S, Harada R, Furukawa K, Okamura N, Tashiro M, Yanai K, Kudo Y, Arai H
- Organizer
  Alzheimer's Association International Conference 2014
- Place of Presentation
  コペンハーゲン
- Year and Date
  2014-07-12 – 2014-07-17
- Data Source
  KAKENHI-PROJECT-25293259
[Presentation] Tau Probe Development: From A Molecular Design To A Clinical Research.
- Author(s)
  Furumoto S., Okamura N., Kudo Y.
- Organizer
  第9回日本分子イメージング学会総会・学術集会
- Place of Presentation
  大阪千里
- Year and Date
  2014-05-22 – 2014-05-23
- Data Source
  KAKENHI-PROJECT-25293259

1. YANAI Kazuhiko (50192787)

# of Collaborated Projects: 10 results

# of Collaborated Products: 99 results
2. FURUMOTO Shozo (00375198)

# of Collaborated Projects: 8 results

# of Collaborated Products: 70 results
3. TASHIRO Manabu (00333477)

# of Collaborated Projects: 7 results

# of Collaborated Products: 35 results
4. KURAMASU Atsuo (90302091)

# of Collaborated Projects: 6 results

# of Collaborated Products: 19 results
5. SAKURAI Eiko (90153949)

# of Collaborated Projects: 5 results

# of Collaborated Products: 31 results
6. FUNAKI Yoshihito (50261491)

# of Collaborated Projects: 5 results

# of Collaborated Products: 4 results
7. WATANABE Takehiko (70028356)

# of Collaborated Projects: 4 results

# of Collaborated Products: 7 results
8. 原田龍一 (60735455)

# of Collaborated Projects: 4 results

# of Collaborated Products: 50 results
9. 行場次朗 (50142899)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
10. KIKUCHI Akio (80463785)

# of Collaborated Projects: 2 results

# of Collaborated Products: 13 results
11. TAKEDA Atsushi (70261534)

# of Collaborated Projects: 2 results

# of Collaborated Products: 10 results
12. KANETA Tomohiro (50323019)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
13. FURUKAWA Katsutoshi (30241631)

# of Collaborated Projects: 2 results

# of Collaborated Products: 10 results
14. 原田愛子 (30778634)

# of Collaborated Projects: 2 results

# of Collaborated Products: 30 results
15. YOSHIKAWA Takeo (70506633)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
16. MEGURO Kenichi (90239559)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
17. ISHIWATA Kiichi (50143037)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. IWATA Ren (60143038)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
19. YAMAZAKI Hiromichi (00166654)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
20. SHIDAHARA Miho (20443070)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
21. 藤盛寿一 (30795844)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 中島一郎 (50333810)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 高瀬圭 (60361094)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 瀧靖之 (10375115)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 領家梨恵 (10737464)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 米田哲也 (20305022)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 舘脇康子 (40722202)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. 関根弘樹 (50506285)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. 中瀬泰然 (60390928)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. KUDO Yukitsuka

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
31. HAYASHI Hiroshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
32. 石川洋一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
33. 川勝忍

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
34. 小林良太

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
35. 松田博史

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
36. 青木正志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
37. 渡部浩司

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
38. 平岡宏太良

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
39. 中村正帆

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
40. 石井賢二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
41. 石垣診祐

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
42. 須原哲也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
43. 樋口真人

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
44. 前田純

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Okamura Nobuyuki 岡村 信行

OKAMURA Nobuyuki 岡村 信行

岡本 信行 オカモト ノブユキ

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Development of diagnostic technique for detection of non-Alzheimer degenerative diseases by visualization of reactive astrocytesPrincipal Investigator

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神経炎症を生体画像化する新規画像バイオマーカーの開発研究Principal Investigator

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Imaging neurofibrillary tangles and astrogliosis for the clarification of the pathogenesis of Alzheimer's diseasePrincipal Investigator

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Search of conformation-specific PET probePrincipal Investigator

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Development of novel imaging biomarker using highly-sensitive tau PET probesPrincipal Investigator

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Development of alpha-synuclein selective PET probePrincipal Investigator

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Clinical application of tau PET probesPrincipal Investigator

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Okamura Nobuyuki 岡村信行

OKAMURA Nobuyuki 岡村信行

岡本信行オカモトノブユキ