OHKOUCHI Shinya 大河内眞也

… Alternative Names

大河内眞也オオコウチシンヤ

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Researcher Number	40375035
Other IDs	https://orcid.org/0000-0002-4658-6487
Affiliation (Current)	2024: 東北大学, 事業支援機構, 准教授
Affiliation (based on the past Project Information) *help	2024: 東北大学, 事業支援機構, 准教授 2017 – 2022: 東北大学, 事業支援機構, 講師 2014 – 2016: 東北大学, 環境・安全推進センター, 講師 2015: 東北大学, 大学院医学系研究科, 講師 2014: 東北大学, 学内共同利用施設等, 講師 … More 2014: 東北大学, 医学系研究科, 講師 2012 – 2013: 東北大学, 大学病院, 助教 2009 – 2012: Tohoku University, 病院, 助教 2005: 東北大, 大学病院 Less
Review Section/Research Field	Principal Investigator Respiratory organ internal medicine / Basic Section 53030:Respiratory medicine-related Except Principal Investigator Basic Section 55040:Respiratory surgery-related / Respiratory organ internal medicine / Basic Section 58030:Hygiene and public health-related: excluding laboratory approach / Basic Section 53030:Respiratory medicine-related / Respiratory surgery / Thoracic surgery
Keywords	Principal Investigator 間葉系幹細胞 / 翻訳後修飾 / メタボローム / エピゲノム / 肺線維症 / STC1 / 成長因子 / 治療 / 間質性肺炎 / 過酸化ストレス … More / 代謝 / 易炎症性 / 加齢肺 / 吸入療法 / 新型コロナウイルス感染症 / 肺障害 / 脱共役呼吸 / SMAD7 / SOCS1 / 抗炎症作用 / 抗線維化作用 / 抗酸化作用 / Stanniocalcin-1 / ミトコンドリア / マクロファージ / SASP / 老化 / 障害ストレス応答 / ERストレス / 酸化ストレス / エピジェネティクス / アメリカ合衆国 / ワルブルグ効果 / 国際情報交換 / TGF-BETA / 液性因子 / 骨髄間葉系幹細胞 / 小胞体ストレス / 特発性肺線維症 / Uncoupling Protein2 / 過酸化 / 肺胞上皮細胞 / 肺胞細胞 / Warburg効果 / 嫌気性代謝 / Uncoupling Protein 2 / アポトーシス / Stanniocalcin1 … More Except Principal Investigator 肺移植 / 慢性拒絶反応 / 間葉系幹細胞 / 移植肺機能不全 / 加齢 / 急性拒絶反応 / 肺幹細胞 / B 細胞 / 免疫逃避 / 免疫チェックポイント / 細胞外小胞 / 慢性移植肺機能不全 / 免疫抑制療法 / 肺移植後急性拒絶反応 / IL-17 / B細胞 / 自然免疫 / 移植免疫 / 線維化 / 肺機能 / じん肺 / フィットテスト / 防護具 / 職業性肺疾患 / 肺機能検査 / 東日本大震災 / 災害労働者 / マイクロアレイ / マウス / 高齢 / RNAシークエンス / 肺水腫 / RNAシーケンス / 高齢ドナー / 虚血・再灌流傷害 / 呼吸器疾患 / COPD / オルガノイド / 呼吸器 / 細胞老化 / 慢性閉塞性肺疾患 / リゾホスファチジン酸 / 細胞治療 / 肺外科 / 肺内気管移植モデル / Muse細胞 / 閉塞性細気管支炎 / 炎症性肺疾患 / 肺組織幹細胞 / 再生医療 / 前駆細胞 / 幹細胞 / サイトカイン / 肺胞内出血 / 浮腫 / リンパ球浸潤 / ラット / 非閉塞性肺疾患癌 / SP-D / miRNA / バイオマーカー / 間質性肺炎 / micro RNA / 循環線維細胞 / Fibrocyte / 呼吸器感染症 / 肺線維症 / 非閉塞性肺疾患 Less

BAFFに注目したB細胞分化が慢性移植肺機能不全に与える影響の検討
- Principal Investigator
  
  渡邉龍秋
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55040:Respiratory surgery-related
- Research Institution
  Tohoku University
Development of pro-inflammatory treatment by cross-sectional control of aging lung metabolism and epigeneticsPrincipal Investigator
- Principal Investigator
  
  大河内眞也
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Tohoku University
免疫逃避機構を応用した新たな肺移植の戦略
- Principal Investigator
  
  兼平雅彦
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55040:Respiratory surgery-related
- Research Institution
  University of Yamanashi
自然免疫とサブタイプに着目した慢性移植肺機能不全のメカニズム解明
- Principal Investigator
  
  渡邉龍秋
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55040:Respiratory surgery-related
- Research Institution
  Tohoku University
新規肺移植後免疫抑制療法の開発を目指した間葉系幹細胞由来の細胞外小胞の解析と応用
- Principal Investigator
  
  大石久
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55040:Respiratory surgery-related
- Research Institution
  Tohoku University
Pulmonary function survey of rescue and recovery workers of the Great East Japan Earthquake
- Principal Investigator
  
  色川俊也
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 58030:Hygiene and public health-related: excluding laboratory approach
- Research Institution
  Tohoku University
Why is prognosis of lung transplant recipient from elderly donors poor? –Elucidation of mechanisms and establishment of therapeutic intervention strategy-
- Principal Investigator
  
  Okada Yoshinori
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55040:Respiratory surgery-related
- Research Institution
  Tohoku University
Elucidation of the pathophysiology of pulmonary fibrosis and development of new treatments by applying metabolome analysisPrincipal Investigator
- Principal Investigator
  
  Ohkouchi Shinya
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Tohoku University
Analysis of a relationship between age-related respiratory diseases and lysophosphatidic acids
- Principal Investigator
  
  Kanehira Masahiko
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  University of Yamanashi
  Tohoku University
The effect of a novel cell therapy for chronic lung allograft dysfunction in animal models
- Principal Investigator
  
  Okada Yoshinori
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Respiratory surgery
- Research Institution
  Tohoku University
Differantial Mechanism of Lung Cells induced by Mesenchymal Stem Cells and the Treatment of Intractable Respiratory DiseasesPrincipal Investigator
- Principal Investigator
  
  Ohkouchi Shinya
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Tohoku University
New Therapy for Intractable Pulmonary Fibrosis using Humoral Factors released from Mesenchymal Stem CellsPrincipal Investigator
- Principal Investigator
  
  OHKOUCHI Shinya
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Tohoku University
Prevention of acute and chronic lung allograft rejection by mesenchymal stem cells
- Principal Investigator
  
  OKADA Yoshinori
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Thoracic surgery
- Research Institution
  Tohoku University
A novel treatment strategy for inflammatory lung diseases, using de-differentiation mechanisms toward bronchiolar stem cells
- Principal Investigator
  
  KIKUCHI Toshiaki
- Project Period (FY)
  2011 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Niigata University
  Tohoku University
Pathogenesis and control of circulating fibrocytes and miRNAs causing interstitial/airway fibrosis and initiating/promoting cancer in the lung
- Principal Investigator
  
  EBINA Masahito
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Tohoku University
Identification of paracrine factors from mesenchaymal stem cell for protection and treatment against lung injuryPrincipal Investigator
- Principal Investigator
  
  OHKOUCHI Shinya
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Tohoku University
癌特異的、癌抑制遺伝子イントロン由来産物を用いた肺癌免疫療法の適応拡大の研究Principal Investigator
- Principal Investigator
  
  大河内眞也
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Tohoku University

[Book] Disaster and Respiratory Diseases2019
- Author(s)
  Ohkouchi Shinya, Yamauchi Kohei, Yamanda Shunsuke, Fujimoto Eisaku
- Total Pages
  178
- Publisher
  Springer
- ISBN
  9789811325977
- Data Source
  KAKENHI-PROJECT-18K08136
[Book] Disaster and Respiratory Disease2018
- Author(s)
  Shinya Ohkouchi, Shinsuke Yamanda, Shu Hisata, Masao Tabata, Toshiya Irokawa, Hiromasa Ogawa, Hajime Kurosawa, Kohei Yamauchi, Keisaku Fujimoto
- Total Pages
  178
- Publisher
  Springer
- ISBN
  9789811325977
- Data Source
  KAKENHI-PROJECT-18K08136
[Book] 呼吸器疾患と慢性炎症2016
- Author(s)
  大河内眞也
- Total Pages
  146
- Publisher
  北隆館
- Data Source
  KAKENHI-PROJECT-15K09205
[Book] イラスト呼吸器学2014
- Author(s)
  共同執筆、編集・一ノ瀬正和、大河内眞也
- Publisher
  文光堂
- Data Source
  KAKENHI-PROJECT-24591149
[Book] 治療薬Up-to-Date2014
- Author(s)
  共同執筆、監修・矢崎義雄、大河内眞也
- Publisher
  メディカルビュー
- Data Source
  KAKENHI-PROJECT-24591149
[Book] 自己免疫性肺胞蛋白症の症例2011
- Author(s)
  大河内眞也、海老名雅仁
- Data Source
  KAKENHI-PROJECT-21590980
[Book] 肺気腫モデル2011
- Author(s)
  大河内眞也
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-21590980
[Book] 特発性肺線維症臨床試験のエビデンス形成2010
- Author(s)
  大河内眞也、貫和敏博
- Publisher
  ライフサイエンス出版
- Data Source
  KAKENHI-PROJECT-21590980
[Book] 典型的自己免疫性肺胞蛋白症症例の明確化に関する研究2010
- Author(s)
  大河内眞也、貫和敏博
- Data Source
  KAKENHI-PROJECT-21590980
[Book] マウスラット疾患モデル活用ハンドブック2010
- Author(s)
  大河内眞也(分担執筆)
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-21590980
[Book] 特発性間質性肺炎2009
- Author(s)
  大河内眞也
- Publisher
  総合医学社
- Data Source
  KAKENHI-PROJECT-21590980
[Journal Article] Targeting stanniocalcin‐1‐expressing tumor cells elicits efficient antitumor effects in a mouse model of human lung cancer2021
- Author(s)
  Abe Kotaro、Kanehira Masahiko、Ohkouchi Shinya、Kumata Sakiko、Suzuki Yamato、Oishi Hisashi、Noda Masafumi、Sakurada Akira、Miyauchi Eisaku、Fujiwara Tohru、Harigae Hideo、Okada Yoshinori
- Journal Title
  
  Cancer Medicine
  
  Volume: 10 Issue: 9 Pages: 3085-3100
- DOI
  10.1002/cam4.3852
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08167, KAKENHI-PROJECT-18K08314, KAKENHI-PROJECT-18K08136, KAKENHI-PROJECT-19K17624, KAKENHI-PROJECT-21K08385
[Journal Article] Risk prediction for new-onset atrial fibrillation using the Minnesota code electrocardiography classification system2021
- Author(s)
  Igarashi Yu、Nochioka Kotaro、Sakata Yasuhiko、Tamai Tokiwa、Ohkouchi Shinya、Irokawa Toshiya、Ogawa Hiromasa、Hayashi Hideka、Fujihashi Takahide、Yamanaka Shinsuke、Shiroto Takashi、Miyata Satoshi、Hata Jun、Yamada Shogo、Ninomiya Toshiharu、Yasuda Satoshi、Kurosawa Hajime、Shimokawa Hiroaki
- Journal Title
  
  IJC Heart & Vasculature
  
  Volume: 34 Pages: 100762-100762
- DOI
  10.1016/j.ijcha.2021.100762
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K11847, KAKENHI-PROJECT-20K10524
[Journal Article] Validation of a new serum granulocyte?macrophage colony-stimulating factor autoantibody testing kit2020
- Author(s)
  Nakata Koh, Tazawa Ryushi, Ohkouchi Shinya, Hirano Taizou, Kitamura Nobutaka
- Journal Title
  
  ERJ Open Research
  
  Volume: 6 Issue: 1 Pages: 00259-2019
- DOI
  10.1183/23120541.00259-2019
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08136
[Journal Article] Kobayashi K, Ohkouchi S, Sasahara Y, Ebina M, Nakata K, Saito R, Akiba M, Sado T, Oishi H, Watanabe T, Kurosawa H, Okada Y. Improvement of native pulmonary alveolar proteinosis after contralateral single living-donor lobar lung transplantation: A case report.2020
- Author(s)
  Kobayashi K, Ohkouchi S, Sasahara Y, Ebina M, Nakata K, Saito R, Akiba M, Sado T, Oishi H, Watanabe T, Kurosawa H, Okada Y.
- Journal Title
  
  Pediatr Transplant
  
  Volume: 24 Issue: 2
- DOI
  10.1111/petr.13659
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09527, KAKENHI-PROJECT-18K08136
[Journal Article] Respiratory resistance among adults in a population-based cohort study in Northern Japan.2019
- Author(s)
  Miura E, Tsuchiya N, Igarashi Y, Arakawa R, Nikkuni E, Tamai T, Tabata M, Ohkouchi S, Irokawa T, Ogawa H, Takai-Igarashi T, Suzuki Y, Kuriyama S, Tamiya G, Hozawa A, Yamamoto M, Kurosawa H.
- Journal Title
  
  Respiratory Investigation
  
  Volume: 印刷中 Issue: 3 Pages: 30226-0
- DOI
  10.1016/j.resinv.2018.12.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09527, KAKENHI-PROJECT-18K11420, KAKENHI-PROJECT-15K00295, KAKENHI-PROJECT-16K08638, KAKENHI-PROJECT-16K09093, KAKENHI-PUBLICLY-19H05200, KAKENHI-PROJECT-18K08136
[Journal Article] Inhaled GM-CSF for Pulmonary Alveolar Proteinosis2019
- Author(s)
  Tazawa R、Ueda T、Abe M、Tatsumi K、Eda R、Kondoh S、Morimoto K、Tanaka T、Yamaguchi E、Takahashi A、Oda M、Ishii H、Izumi S、Sugiyama H、Nakagawa A、Tomii K、Suzuki M、Konno S、Ohkouchi S、Tode N、Handa T、Hirai T、Inoue Y、Arai T、Asakawa K、Sakagami T、Hashimoto A、Tanaka T、Takada T、Mikami A、Kitamura N、Nakata K
- Journal Title
  
  New England Journal of Medicine
  
  Volume: 381 Issue: 10 Pages: 923-932
- DOI
  10.1056/nejmoa1816216
- NAID
  120007087887
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K16037, KAKENHI-PROJECT-18K08136
[Journal Article] Incidence of autoimmune pulmonary alveolar proteinosis estimated using Poisson distribution2019
- Author(s)
  Kitamura Nobutaka、Ohkouchi Shinya、Tazawa Ryushi、Ishii Haruyuki、Takada Toshinori、Sakagami Takuro、Tanaka Takahiro、Nakata Koh
- Journal Title
  
  ERJ Open Research
  
  Volume: 5 Issue: 1 Pages: 00190-2018
- DOI
  10.1183/23120541.00190-2018
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08136
[Journal Article] Peripheral alveolar nitric oxide concentration reflects alveolar inflammation in autoimmune pulmonary alveolar proteinosis.2018
- Author(s)
  Hirano T, Ohkouchi S, Tode N, Kobayashi M, Ono M, Satoh T, Mitsuishi Y, Watanabe A, Tabata M, Irokawa T, Ogawa H, Sugiura H, Kikuchi T, Akasaka K, Tazawa R, Inoue Y, Nakata K, Kurosawa H, Ichinose M.
- Journal Title
  
  ERJ open research
  
  Volume: 4 Issue: 1 Pages: 00071-2017
- DOI
  10.1183/23120541.00071-2017
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09205, KAKENHI-PROJECT-15K15316, KAKENHI-PROJECT-15K15321, KAKENHI-PROJECT-16K09530, KAKENHI-PROJECT-18K08136, KAKENHI-PROJECT-16H05307, KAKENHI-PROJECT-17H04180, KAKENHI-PROJECT-16K09093, KAKENHI-PROJECT-16K15453
[Journal Article] Bone marrow mesenchymal stromal cells protect allograft lung transplants from acute rejection via the PD-L1/IL-17A axis2018
- Author(s)
  Ishibashi Naoya、Watanabe Tatsuaki、Kanehira Masahiko、Watanabe Yui、Hoshikawa Yasushi、Notsuda Hirotsugu、Noda Masafumi、Sakurada Akira、Ohkouchi Shinya、Kondo Takashi、Okada Yoshinori
- Journal Title
  
  Surgical Today
  
  Volume: 48 Issue: 7 Pages: 726-734
- DOI
  10.1007/s00595-018-1643-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09205, KAKENHI-PROJECT-18K08136, KAKENHI-PROJECT-18K08167
[Journal Article] Sequential GM-CSF inhalation after whole lung lavage for pulmonary alveolar proteinosis: a report of five intractable cases.2017
- Author(s)
  Ohkouchi S, Akasaka K, Ichiwata T, Hisata S, Iijima H, Takada T, Tsukada H, Nakayama H, Machiya J, Irokawa T, Ogawa H, Shibata Y, Ichinose M, Ebina M, Nukiwa T, Kurosawa H, Nakata K, Tazawa R.
- Journal Title
  
  Ann Am Thorac Soc
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K09205
[Journal Article] A Semiquantitative Computed Tomographic Grading System for Evaluating Therapeutic Response in Pulmonary Alveolar Proteinosis2017
- Author(s)
  Tokura Sayoko、Akira Masanori、Okuma Tomohisa、Tazawa Ryushi、Arai Toru、Sugimoto Chikatoshi、Matsumuro Akiko、Hirose Masaki et al.
- Journal Title
  
  Annals of the American Thoracic Society
  
  Volume: 14 Issue: 9 Pages: 1403-1411
- DOI
  10.1513/annalsats.201607-574oc
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09203, KAKENHI-PROJECT-15K09205, KAKENHI-PROJECT-15K15321
[Journal Article] Exome sequencing deciphers a germline MET mutation in familial epidermal growth factor receptor-mutant lung cancer.2017
- Author(s)
  Tode N, Kikuchi T, Sakakibara T, Hirano T, Inoue A, Ohkouchi S, Tamada T, Okazaki T, Koarai A, Sugiura H, Niihori T, Aoki Y, Nakayama K, Matsumoto K, Matsubara Y, Yamamoto M, Watanabe A, Nukiwa T, Ichinose M.
- Journal Title
  
  Cancer Sci
  
  Volume: 印刷中 Issue: 6 Pages: 1263-1270
- DOI
  10.1111/cas.13233
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16H05307, KAKENHI-PROJECT-26293059, KAKENHI-PROJECT-26293195, KAKENHI-PROJECT-15K14473, KAKENHI-PROJECT-16K14664, KAKENHI-PROJECT-16K15453, KAKENHI-PROJECT-17K16037, KAKENHI-PROJECT-17H04180, KAKENHI-PROJECT-15K09205, KAKENHI-PROJECT-15K15316
[Journal Article] Sequential GM-CSF Inhalation after Whole Lung Lavage for Pulmonary Alveolar Proteinosis: A Report of Five Intractable Cases.2017
- Author(s)
  Ohkouchi S, Akasaka K, Ichiwata T, Hisata S, Iijima H, Takada T, Tsukada H, Nakayama H, Machiya JI, Irokawa T, Ogawa H, Shibata Y, Ichinose M, Ebina M, Nukiwa T, Kurosawa H, Nakata K, Tazawa R
- Journal Title
  
  Ann Am Thorac Soc.
  
  Volume: 72 Issue: 8 Pages: 1074-1083
- DOI
  10.1513/annalsats.201611-892bc
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05307, KAKENHI-PROJECT-15K09205, KAKENHI-PROJECT-15K15321
[Journal Article] Pathological features of explant lungs with fibrosis in autoimmune pulmonary alveolar proteinosis2017
- Author(s)
  Ono Manabu、Saito Ryoko、Tominaga Junya、Okada Yoshinori、Ohkouchi Shinya、Takemura Tamiko
- Journal Title
  
  Respirol Case Rep.
  
  Volume: 5 Issue: 5 Pages: e00255-e00255
- DOI
  10.1002/rcr2.255
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09205
[Journal Article] Peripheral Alveolar Nitric Oxide Concentration Reflects Macrophage Inflammation in Auto-Immune Pulmonary Alveolar Proteinosis2017
- Author(s)
  Taizou Hirano, Shinya Ohkouchi, Naoki Tode, Makoto Kobayashi, Manabu Ono, Teruyuki Satoh, Yoichiro Mitsuishi, Akira Watanabe, Masao Tabata, Toshiya Irokawa, Hiromasa Ogawa, Hisatoshi Sugiura, Toshiaki Kikuchi, Keiichi Akasaka, Ryushi Tazawa, Yoshikazu Inoue, Koh Nakata, Hajime Kurosawa and Masakazu Ichinose
- Journal Title
  
  ERJ open research
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K09205
[Journal Article] A Semiquantitative CT Grading System for Evaluating Therapeutic Response in Pulmonary Alveolar Proteinosis2017
- Author(s)
  Sayoko Tokura, Masanori Akira, Tomohisa Okuma, Ryushi Tazawa, Toru Arai, Chikatoshi Sugimoto, Toshinori Takada, Koh Nakata, Haruyuki Ishii, Yasunori Kasahara, Masayuki Hojo, Shinya Ohkouchi, Yoshikazu Inoue
- Journal Title
  
  Ann Am Thorac Soc
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09205
[Journal Article] Mesenchymal stem cells attenuate ischemia-reperfusion injury after prolonged cold ischemia in a mouse model of lung transplantation: a preliminary study.2017
- Author(s)
  Watanabe T, Hoshikawa Y, Ishibashi N, Suzuki H, Notsuda H, Watanabe Y, Noda M, Kanehira M, Ohkouchi S, Kondo T, Okada Y.
- Journal Title
  
  Surg Today
  
  Volume: 47 Issue: 4 Pages: 425-425
- DOI
  10.1007/s00595-016-1391-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09205, KAKENHI-PROJECT-15K09465
[Journal Article] Fractional Exhaled Nitric Oxide (FeNO) and Spirometry as INdicators of Inhalation Exposure to Chemical Agents in Pathology Workers2017
- Author(s)
  Ritsuko Arakawa Suzuki, Toshiya Irokawa, Hiromasa Ogawa, Shinya Ohkouchi, Masao Tabata, Susumu Togashi, Takeshi Nakamura, Noriko Ohisa, Etsuhiro Nikkuni, Emiri Miura, Kaoru Yoshida, Hioshi Inomata and Hajime Kurosawa
- Journal Title
  
  Journal of Occupational and Environmental Medicine
  
  Volume: in press Issue: 5 Pages: 467-473
- DOI
  10.1097/jom.0000000000000976
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09093, KAKENHI-PROJECT-16K09527, KAKENHI-PROJECT-15K09205
[Journal Article] A mathematical model to predict protein wash out kinetics during whole-lung lavage in autoimmune pulmonary alveolar proteinosis.2015
- Author(s)
  Akasaka K, （12名略）， Tazawa R, (7名略) Nakata K.
- Journal Title
  
  Am J Physiol Lung Cell Mol Physiol
  
  Volume: 308 Issue: 2 Pages: 105-117
- DOI
  10.1152/ajplung.00239.2014
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-22242001, KAKENHI-PROJECT-24406027, KAKENHI-PROJECT-25461153, KAKENHI-PROJECT-15K09205
[Journal Article] Outcome of corticosteroid administration in autoimmune pulmonary alveolar proteinosis: a retrospective cohort study2015
- Author(s)
  Keiichi Akasaka, Takahiro Tanaka, Nobutaka Kitamura, Shinya Ohkouchi, Ryushi Tazawa, Toshinori Takada, Toshio Ichiwata, Etsuro Yamaguchi, Masaki Hirose, Toru Arai, Kentaro Nakano, Takahito Nei, Haruyuki Ishii, Tomohiro Handa, Yoshikazu Inoue and Koh Nakata
- Journal Title
  
  BMC Pulmonary Medicine
  
  Volume: 15 Issue: 1 Pages: 88-88
- DOI
  10.1186/s12890-015-0085-0
- NAID
  120005758416
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09203, KAKENHI-PROJECT-15K09205, KAKENHI-PROJECT-15K15321, KAKENHI-PROJECT-15H04829, KAKENHI-PROJECT-25461153, KAKENHI-PROJECT-26305028
[Journal Article] 若年性肺線維症(遺伝性間質性肺疾患を中心として)2015
- Author(s)
  大河内眞也
- Journal Title
  
  呼吸
  
  Volume: 34 Pages: 402-8
- Data Source
  KAKENHI-PROJECT-15K09205
[Journal Article] Workplace patrol reported in the disaster waste treatment plants at the Great East Japan Earthquake disaster area2015
- Author(s)
  Irokawa T, Hanaue K, Arakawa R, Nikkuni E, Kiuchi K, Ohkouchi S, Ogawa H, Hirose T, Kurosawa H.
- Journal Title
  
  Sangyo Eiseigaku Zasshi
  
  Volume: 57 Pages: 37-9
- NAID
  130005064866
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K09205
[Journal Article] Mesenchymal Stem Cells Correct Inappropriate Epithelial-mesenchyme Relation in Pulmonary Fibrosis Using Stanniocalcin-1.2015
- Author(s)
  Ono M, Ohkouchi S, Kanehira M, Tode N, Kobayashi M, Ebina M, Nukiwa T, Irokawa T, Ogawa H, Akaike T, Okada Y, Kurosawa H, Kikuchi T, Ichinose M.
- Journal Title
  
  Mol Ther
  
  Volume: 23 Issue: 3 Pages: 549-560
- DOI
  10.1038/mt.2014.217
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22240066, KAKENHI-PROJECT-23390219, KAKENHI-PROJECT-24591149, KAKENHI-PROJECT-24659399, KAKENHI-PROJECT-25220103, KAKENHI-PROJECT-25253020, KAKENHI-PLANNED-26111008, KAKENHI-PROJECT-26670207, KAKENHI-PROJECT-15K09205
[Journal Article] Myriad Functions of Stanniocalcin-1 (STC1) Cover Multiple Therapeutic Targets in the Complicated Pathogenesis of Idiopathic Pulmonary Fibrosis (IPF).2015
- Author(s)
  Ohkouchi S, Ono M, Kobayashi M, Hirano T, Tojo Y, Hisata S, Ichinose M, Irokawa T, Ogawa H, Kurosawa H.
- Journal Title
  
  Clin Med Insights Circ Respir Pulm Med
  
  Volume: 9 Pages: 91-6
- DOI
  10.4137/ccrpm.s23285
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K09205
[Journal Article] Duration of benefit in patients with autoimmune pulmonary alveolar proteinosis after inhaled granulocyte-macrophage colony-stimulating factor therapy.2014
- Author(s)
  Tazawa R, Inoue Y, Arai T, Takada T, Kasahara Y, Hojo M, Ohkouchi S, Tsuchihashi Y, Yokoba M, Eda R, Nakayama H, Ishii H, Nei T, Morimoto K, Nasuhara Y, Ebina M, Akira M, Ichiwata T, Tatsumi K, Yamaguchi E, Nakata K.
- Journal Title
  
  Chest
  
  Volume: 145 Issue: 4 Pages: 729-737
- DOI
  10.1378/chest.13-0603
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-22242001, KAKENHI-PROJECT-24390208, KAKENHI-PROJECT-24406027, KAKENHI-PROJECT-24591149, KAKENHI-PROJECT-25461151, KAKENHI-PROJECT-25461153
[Journal Article] INPULSIS Trial Investigators. Efficacy and safety of nintedanib in idiopathic pulmonary fibrosis2014
- Author(s)
  Richeldi L, du Bois RM, Raghu G, Azuma A, Brown KK, Costabel U, Cottin V, Flaherty KR, Hansell DM, Inoue Y, Kim DS, Kolb M, Nicholson AG, Noble PW, Selman M, Taniguchi H, Brun M, Le Maulf F, Girard M, Stowasser S, Schlenker-Herceg R, Disse B, Collard HR
- Journal Title
  
  N Engl J Med
  
  Volume: 29 Issue: 22 Pages: 2071-82
- DOI
  10.1056/nejmoa1402584
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24406027, KAKENHI-PROJECT-24591149
[Journal Article] Human marrow stromal cells downsize the stem cell fraction of lung cancers by fibroblast growth factor 10.2014
- Author(s)
  Kanehira M, Kikuchi T, Santoso A, Tode N, Hirano T, Ohkouchi S, Tamada T, Sugiura H, Harigae H, Ichinose M.
- Journal Title
  
  Mol Cell Biol
  
  Volume: 34 Issue: 15 Pages: 2848-56
- DOI
  10.1128/mcb.00871-13
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-23390219, KAKENHI-PROJECT-24591149, KAKENHI-PROJECT-24591150, KAKENHI-PROJECT-24659399, KAKENHI-PROJECT-26293195
[Journal Article] Deterioration in regional health status after the acute phase of a great disaster: respiratory physicians' experiences of the Great East Japan Earthquake.2013
- Author(s)
  Ohkouchi S, Shibuya R, Yanai M, Kikuchi Y, Ichinose M, Nukiwa T.
- Journal Title
  
  Respir Investig.
  
  Volume: 51 Issue: 2 Pages: 50-55
- DOI
  10.1016/j.resinv.2012.12.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591149
[Journal Article] Development of pulmonary alveolar proteinosis following exposure to dust after the Great East Japan Earthquake.2013
- Author(s)
  Hisata S, Moriyama H, Tazawa R, Ohkouchi S, Ichinose M, Ebina M.
- Journal Title
  
  Respir Investig
  
  Volume: 51 Issue: 4 Pages: 212-216
- DOI
  10.1016/j.resinv.2013.04.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22242001, KAKENHI-PROJECT-24591149, KAKENHI-PROJECT-25461153
[Journal Article] Fatal acute interstitial pneumonia in a worker making chips from wooden debris generated by the Great East Japan earthquake and tsunami.2012
- Author(s)
  Ohkouchi S, Ebina M, Kamei K, Moriyama H, Tamai T, Shibuya R, Ichinose M, Nukiwa T.
- Journal Title
  
  Respir Investig.
  
  Volume: 4 Issue: 4 Pages: 129-134
- DOI
  10.1016/j.resinv.2012.09.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591149
[Journal Article] Targeting lysophosphatidic acid signaling retards culture-associated senescence of human marrow stromal cells2012
- Author(s)
  Kanehira M, Kikuchi T, Ohkouchi S, Shibahara T, Tode N, Santoso A, Daito H, Ohta H, Tamada T, Nukiwa T
- Journal Title
  
  PLoS One
  
  Volume: 7 Issue: 2 Pages: e32185-e32185
- DOI
  10.1371/journal.pone.0032185
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249052, KAKENHI-PROJECT-21590980, KAKENHI-PROJECT-23390219, KAKENHI-PROJECT-23790895, KAKENHI-PROJECT-24659399
[Journal Article] Runx1-deficiency in CD4+ T Cells Causes Fatal Autoimmune Inflammatory Lung Disease due to Spontaneous Hyperactivation of Cells2012
- Author(s)
  Wong WF
- Journal Title
  
  J. Immunol.
  
  Volume: 188 Issue: 10 Pages: 5408-5420
- DOI
  10.1038/bjc.2012.422
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390164, KAKENHI-PROJECT-22790746, KAKENHI-PROJECT-24591184, KAKENHI-PROJECT-24592826
[Journal Article] Mesenchymal stromal cells protect cancer cells from ROS-induced apoptosis and enhance the Warburg effect by secreting STC12012
- Author(s)
  Ohkouchi S, Block GJ, Katsha AM, Kanehira M, Ebina M, Kikuchi T, Saijo Y, Nukiwa T, Prockop DJ
- Journal Title
  
  Mol Ther
  
  Volume: 20(2) Issue: 2 Pages: 417-23
- DOI
  10.1038/mt.2011.259
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590980, KAKENHI-PROJECT-23790895, KAKENHI-PROJECT-24659399
[Journal Article] Mesenchymal stromal cells (MSCs) protect cancer cells from ROS-induced apoptosis and enhance the Warburg effect by secreting STC12012
- Author(s)
  Ohkouchi S, Block GJ, Katsha AM, Kanehira M, Ebina M, Kikuchi T, Saijo Y, Nukiwa T, Prockop DJ
- Journal Title
  
  Molecular Therapy
  
  Volume: 20 Pages: 417-423
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390164
[Journal Article] Mesenchymal stromal cells protect cancer cells from ROS-induced apoptosis and enhance the Warburg effect by secreting STC12012
- Author(s)
  Ohkouchi S, Block GJ, Katsha AM, Kanehira M, Ebina M, Kikuchi T, Saijo Y, Nukiwa T, Prockop DJ
- Journal Title
  
  Mol Ther
  
  Volume: 20 Pages: 417-423
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390219
[Journal Article] Targeting lysophosphatidic Acid signaling retards culture-associated senescence of human marrow stromal cells2012
- Author(s)
  Kanehira M, KikuchiT, Ohkouchi S, Shibahara T, Tode N, Santoso A, Daito H, Ohta H, Tamada T, Nukiwa T
- Journal Title
  
  PLoS One
  
  Volume: 7(2) Pages: 32185-32185
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590980
[Journal Article] Stanniocalcin-1 from Marrow Stromal Cells (MSC) Rescues Injured Lung Cancer Epithelial Cells by Upregulation of Uncoupling Protein 22011
- Author(s)
  Shinya Ohkouchi, Gregory Block, Prockop Darwin, Toshihiro Nukiwa
- Journal Title
  
  Proceedings of the National Academy of Science of the United States of America (PNAS)
  
  Volume: (In Press)(未定)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590980
[Journal Article] Gradual increase of high mobility group protein b1 in the lungs after the onset of acute exacerbation of idiopathic pulmonary fibrosis2011
- Author(s)
  Ebina M, Ohkouchi S, Nukiwa T, et al
- Journal Title
  
  Pulm Med
  
  Volume: 916486
- NAID
  120005761658
- Data Source
  KAKENHI-PROJECT-21590980
[Journal Article] Paracrine Factors of Multipotent Stromal Cells Ameliorate Lung Injury in an Elastase-induced Emphysema Model2011
- Author(s)
  Katsha AM, Ohkouchi S, Xin H, Kanehira M, Sun R, Nukiwa T, Saijo Y
- Journal Title
  
  Molecular Therapy
  
  Volume: 19 1 Pages: 196-203
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590980
[Journal Article] Paracrine Factors of Multipotent Stromal Cells Ameliorate Lung Injury in an Elastase-induced Emphysema Model2011
- Author(s)
  Ahmad Katsha, Shinya Ohkouchi, Toshihiro Nukiwa, Yasuo Saijo
- Journal Title
  
  Molecular Therapy
  
  Volume: 19 Issue: 1 Pages: 196-203
- DOI
  10.1038/mt.2010.192
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590980, KAKENHI-PROJECT-22659160
[Journal Article] Multipotent stromal cells are activated to reduce apoptosis in part by upregulation and secretion of stanniocalcin-1.2009
- Author(s)
  Gregory Block, Shinya Ohkouchi, Darwin Prockop Double first
- Journal Title
  
  Stem Cells 27
  
  Pages: 670-81
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590980
[Patent] コロナウイルス感染症の予防または治療剤2021
- Inventor(s)
  大河内眞也
- Industrial Property Rights Holder
  大河内眞也
- Industrial Property Rights Type
  特許
- Filing Date
  2021
- Data Source
  KAKENHI-PROJECT-18K08136
[Patent] PHARMACEUTICAL COMPOSITION FOR PREVENTION OR TREATING FIBROSIS2014
- Inventor(s)
  Shinya Ohkouchi
- Industrial Property Rights Holder
  Shinya Ohkouchi
- Industrial Property Rights Type
  特許
- Filing Date
  2014-02-24
- Overseas
- Data Source
  KAKENHI-PROJECT-24591149
[Patent] PHARMACEUTICAL COMPOSITION FOR PREVENTION OR TREATING FIBROSIS2013
- Inventor(s)
  Shinya Ohkouchi
- Industrial Property Rights Holder
  Shinya Ohkouchi
- Industrial Property Rights Type
  特許
- Filing Date
  2013-07-12
- Overseas
- Data Source
  KAKENHI-PROJECT-24591149
[Patent] 線維症予防又は治療用医薬組成物2013
- Inventor(s)
  大河内眞也
- Industrial Property Rights Holder
  大河内眞也
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2011-152392
- Filing Date
  2013-07-09
- Data Source
  KAKENHI-PROJECT-24591149
[Patent] ケトーシス又はケトアシドーシス予防又は治療剤2011
- Inventor(s)
  大河内眞也
- Industrial Property Rights Holder
  国立大学法人東北大学
- Filing Date
  2011-01-12
- Data Source
  KAKENHI-PROJECT-21590980
[Patent] 線維症予防又は治療用医薬組成物2011
- Inventor(s)
  大河内眞也
- Industrial Property Rights Holder
  国立大学法人東北大学
- Filing Date
  2011-02-10
- Data Source
  KAKENHI-PROJECT-21590980
[Patent] (仮)Stanniocalcin-1を用いたケトーシスの治療について2011
- Inventor(s)
  大河内眞也
- Industrial Property Rights Holder
  国立大学法人東北大学
- Filing Date
  2011-01-12
- Data Source
  KAKENHI-PROJECT-21590980
[Presentation] 救命・救助活動に従事する消防署員の防護マスク装着状況　東日本大震災当時の調査から2022
- Author(s)
  色川俊也, 片岡克巳, 荒川梨津子, 五十嵐侑, 村上知正, 新國悦弘, 大河内眞也, 小川浩正, 黒澤一
- Organizer
  第95回日本産業衛生学会
- Data Source
  KAKENHI-PROJECT-20K10524
[Presentation] 救命・救助活動に従事する消防署員の防護マスク装着状況について～東日本大震災当時の調査結果からわかったこと～2022
- Author(s)
  色川俊也, 片岡克巳, 荒川梨津子, 五十嵐侑, 村上知正, 新國悦弘, 大河内眞也, 小川浩正, 黒澤一
- Organizer
  第95回日本産業衛生学会
- Data Source
  KAKENHI-PROJECT-20K10524
[Presentation] 宮城県内産業保健従事者の新型コロナウイルス感染症第6波下での活動状況2022
- Author(s)
  荒川梨津子, 大河内眞也, 色川俊也, 岩渕範好, 森弘毅, 竹澤公子, 清治邦章, 五十嵐侑, 広瀨俊雄, 小川浩正, 黒澤一
- Organizer
  第81回日本産業衛生学会東北地方会
- Data Source
  KAKENHI-PROJECT-20K10524
[Presentation] 20年の経過で肺移植に至ったインジウム作業従事者の一例2022
- Author(s)
  大河内眞也, 井上千裕, 天田敦子, 色川俊也, 小川浩正, 長南達也, 黒澤一
- Organizer
  第95回日本産業衛生学会
- Data Source
  KAKENHI-PROJECT-20K10524
[Presentation] 使い捨て防護手袋の有機溶剤曝露前後における表面性状変化の観察2022
- Author(s)
  中村剛, 岡田夏美, 色川俊也, 庄司こずえ, 冨樫晋, 大河内眞也, 小川浩正, 三上恭訓, 服部徹太郎, 黒澤一
- Organizer
  第95回日本産業衛生学会
- Data Source
  KAKENHI-PROJECT-20K10524
[Presentation] 教育・研究機関における作業環境測定を利用した管理シートの安全衛生管理への活用.2021
- Author(s)
  中村剛,色川俊也,小川浩正,大河内眞也,玉井ときわ,田畑雅央,佐藤和則,鍛冶光司, 吉田裕美, 本間誠, 三上恭訓, 冨樫晋, 服部徹太郎, 黒澤一
- Organizer
  第94回日本産業衛生学.
- Data Source
  KAKENHI-PROJECT-20K10524
[Presentation] 「仙台産業医学推進協議会～COVID19 ワクチン摂取に関わる今後の職場の課題と事業場・産業保健職の対応について～」のご報告2021
- Author(s)
  大河内眞也, 色川俊也, 五十嵐侑, 荒川梨津子, 漆山祐希, 望月るり子, 大内みやこ, 小川浩正, 広瀨俊雄, 森弘毅, 岩渕範好, 黒澤一
- Organizer
  第80回日本産業衛生学会東北地方会.
- Data Source
  KAKENHI-PROJECT-20K10524
[Presentation] 新型コロナ感染症流行下での産業保健活動におけるVR・ARデバイスの活用.2021
- Author(s)
  色川俊也,中谷敦,五味遼太,田中雄大,中村剛,菅野恭加,五十嵐侑,新國悦弘, 荒川梨津子, 大河内眞也, 小川浩正, 北村喜文, 黒澤一
- Organizer
  第80回日本産業衛生学会東北地方会.
- Data Source
  KAKENHI-PROJECT-20K10524
[Presentation] 睡眠呼吸障害評価のための呼気CO2指標の確立2021
- Author(s)
  小川浩正, 色川俊也,宍倉裕,大河内眞也,杉浦久敏,黒澤一
- Organizer
  第61回日本呼吸器学会学術講演会.
- Data Source
  KAKENHI-PROJECT-20K10524
[Presentation] ミネラル調節ホルモンStanniocalcin-1を標的とした新たな肺がん治療法の可能性2020
- Author(s)
  兼平雅彦、阿部晧太郎、大河内眞也、岡田克典
- Organizer
  第１６３回日本獣医学会学術集会
- Data Source
  KAKENHI-PROJECT-18K08167
[Presentation] Stanniocalcin-1 (STC1) Affects SMAD7 Epigenetics, Increases Glutathione Synthesis And Ameliorate Bleomycin Fibrosis Through Regulating Integrated Metabolic Pathways2020
- Author(s)
  Shinya Ohkouchi
- Organizer
  米国胸部学会（ATS)　年次総会　2020　フィラデルフィア
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08136
[Presentation] tanniocalcin-1 (STC1) Affects SMAD7 Epigenetics, Increases Glutathione Synthesis and Ameliorate Bleomycin Fibrosis Through Regulating Integrated Metabolic Pathways2020
- Author(s)
  Shinya Ohkouchi
- Organizer
  米国胸部学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08136
[Presentation] Comprehensive metabolome analysis reveals new mechanism of anti-fibrotic factor Stanniocalcin-1 (STC1) which modulate epigenetic regulation and oxidative stress2019
- Author(s)
  Shinya Ohkouchi
- Organizer
  アジア太平洋呼吸器学会（APSR)　年次総会　2019　ハノイ
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08136
[Presentation] Comprehensive metabolome analysis reveals new mechanism of anti-fibrotic factor Stanniocalcin-1 (STC1) which modulate epigenetic regulation and oxidative stress2019
- Author(s)
  Shinya Ohkouchi
- Organizer
  米国胸部臨床学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08136
[Presentation] New Insights of the Pathology of Pulmonary Fibrosis Revealed by Metabolome Analysis2018
- Author(s)
  Shinya Ohkouchi
- Organizer
  米国胸部臨床学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08136
[Presentation] New Insights of the Pathology of Pulmonary Fibrosis Revealed by Metabolome Analysis2018
- Author(s)
  Shinya Ohkouchi
- Organizer
  太平洋アジア呼吸器学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08136
[Presentation] Anti-fibrotic Factor Stanniocalcin1 (STC1) and Systemic Damage Response2018
- Author(s)
  Shinya Ohkouchi
- Organizer
  日本呼吸器学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08136
[Presentation] 1.Peripheral Alveolar Nitric Oxide Concentration Reflects Macrophage Inflammation of Auto-Immune Pulmonary Alveolar Proteinosis2017
- Author(s)
  大河内眞也
- Organizer
  米国呼吸器学会（ATS)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09205
[Presentation] 2.PERIPHERAL ALVEOLAR NITRIC OXIDE CONCENTRATION REFLECTS MACROPHAGE　INFLAMMATION OF AUTO‐IMMUNE PULMONARY ALVEOLAR PROTEINOSIS (APAP)2017
- Author(s)
  大河内眞也
- Organizer
  アジア太平洋呼吸器学会（APSR)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09205
[Presentation] SEQUENTIAL GM-CSF INHALATION ENCOURAGES THE EFFICIENCY OF WHOLE LUNG LAVAGE TO TREAT AUTO-IMMUNE PULMONARY ALVEOLAR PROTEINOSIS2016
- Author(s)
  S. Ohkouchi, T. Ichiwata, R. Tazawa, M. Tabata, T. Irokawa, H. Ogawa, K. Nakata, H. Kurosawa
- Organizer
  APSR　2016
- Place of Presentation
  Bangkok, Thai
- Year and Date
  2016-11-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09205
[Presentation] Pathological Findings of Removal Lungs from a Patient with Refractory Fibrotic Autoimune Pulmonary Alveolar Proteinosis After Bilateral Lung Transplantation2016
- Author(s)
  S. Ohkouchi, R. Saitou, J. Tominaga, M. Kobayashi, T. Hirano, M. Ichinose, Y. Okada, H. Kurosawa
- Organizer
  ATS 2016
- Place of Presentation
  San Francisco, USA
- Year and Date
  2016-05-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09205
[Presentation] Fractional Exhaled Nitric Oxide (FeNO) as a Biomarker for Formaldehyde Inhalation Exposure2016
- Author(s)
  R. Arakawa, T. Irokawa, H. Inomata, H. Ogawa, S. Ohkouchi, E. Nikkuni, K. Kiuchi, E. Miura, H. Kurosawa
- Organizer
  ATS 2016
- Place of Presentation
  San Francisco, USA
- Year and Date
  2016-05-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09205
[Presentation] Effects of Weight Loss Therapy on Respiratory System Impedance in Obese Subjects2016
- Author(s)
  E. Nikkuni, K. Kiuchi, R. Arakawa, D. Kobayasi, E. Miura, S. Ohkouchi, T. Irokawa, H. Ogawa, H. Kurosawa
- Organizer
  ATS 2016
- Place of Presentation
  San Francisco, USA
- Year and Date
  2016-05-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09205
[Presentation] New Promising Therapy for Idiopathic Pulmonary Fibrosis and Its Application Using Wound Healing Facilitator Stannioclaicn-1 (STC1)2016
- Author(s)
  S. Ohkouchi, M. Ono, M. Ichinose, H. Kurosawa
- Organizer
  ATS 2016
- Place of Presentation
  San Francisco, USA
- Year and Date
  2016-05-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09205
[Presentation] Regulation of Lung Injuries through Reducing Endoplasmic Reticulum Stress Using Stanniocalcin-1 (STC1) in Pulmonary Fibrosis2016
- Author(s)
  Shinya Ohkouchi,Manabu Ono, Hajime Kurosawa
- Organizer
  JRS 2016
- Place of Presentation
  Kyoto（国立京都国際会館）
- Year and Date
  2016-04-08
- Data Source
  KAKENHI-PROJECT-15K09205
[Presentation] Sequential GM-CSF Inhalation Reinforces the Efficiency of Whole Lung Lavage to Treat Auto-Immune Pulmonary Alveolar Proteinosis2015
- Author(s)
  Shinya Ohkouchi, , Keiichi Akasaka, Toshio Ichiwata, Masakazu Ichinose, Hajime Kurosawa, Koh Nakata, Ryushi Tazawa
- Organizer
  ATS2015
- Place of Presentation
  United States of America(Denver)
- Year and Date
  2015-05-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09205
[Presentation] The Analysis Of Alveolar Macrophage Form On BALF Specimens In Secondary Pulmonary Alveolar Proteinosis2015
- Author(s)
  Haruyuki Ishii, , Ryushi Tazawa, Yoshikazu Inoue, Takeshi Saraya, Takashi Koide, Tomohiro Handa, Masato Morita, Shigeki Yamamoto, Yoshinori Tanino, Shinya Ohkouchi, Keisuke Tomii, Koh Nakata
- Organizer
  ATS2015
- Place of Presentation
  United States of America(Denver)
- Year and Date
  2015-05-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09205
[Presentation] MSCs (Mesenchymal Stem Cells) Reduce ER (Endoplasmic Reticulum) Stress and Correct Inappropriate Epithelial Mesenchyme Relation in Pulmonary Fibrosis Using STC1 (Stanniocalcin-1)2015
- Author(s)
  Shinya Ohkouchi
- Organizer
  ASGCT 18th annual meeting
- Place of Presentation
  United States of America（New Orleans)
- Year and Date
  2015-05-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09205
[Presentation] utcome of Corticosteroids Therapy in Autoimmune Pulmonary Alveolar Proteinosis2015
- Author(s)
  Keiichi Akasaka, Takahiro Tanaka, Keiko Shiiya, , Atsushi Hashimoto, Haruyuki Ishii, Shinya Ohkouchi, Ryushi Tazawa, Nobutaka Kitamura, Toshinori Takada, Koh Nakata
- Organizer
  ATS2015
- Place of Presentation
  United States of America(Denver)
- Year and Date
  2015-05-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09205
[Presentation] A Mathematical Model that Estimates the Amount of Eliminated GM-CSF Autoantibody by Whole-Lung Lavage in Autoimmune Pulmonary Alveolar Proteinosis2015
- Author(s)
  Takahiro Tanaka, Keiichi Akasaka, Takashi Maruyama, Nobutaka Kitamura, , Atsushi Hashimoto, Keiko Shiiya, Yuuko Itoh, Shinya Ohkouchi, Ryushi Tazawa, Etsuro Yamaguchi, Toshio Ichiwata, Masaki Hirose, Toru Arai, Yoshikazu Inoue, Hirosuke Kobayashi, Koh Nakata
- Organizer
  ATS2015
- Place of Presentation
  United States of America(Denver)
- Year and Date
  2015-05-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09205
[Presentation] The Enhancement Of Stanniocalcin-1 (STC1) Secretion Increases The Ability Of Mesenchymal Stem Cells (MSCs) Reducing Bleomycin-Induced Lung Fibrosis In Mice Model Through Inhibition Of ROS/Endoplasmic Reticulum Stress (ER-Stress)/TGFβ1 Pathway2014
- Author(s)
  M. Ono, graduate student, S. Ohkouchi, M.D. PhD., M. Kanehira, PhD, N. Tode, MD, T. Kikuchi, MD, PhD, M. Ichinose, Prof
- Organizer
  ATS 2014 San Diego
- Place of Presentation
  San Diego USA
- Data Source
  KAKENHI-PROJECT-24591149
[Presentation] 多型縦列反復配列（VNTR）を用いた菌ゲノム解析による非結核性抗酸菌症の治療反応性予測2013
- Author(s)
  菊地利明、榊原智博、玉田勉、小橋吉博、福原達朗、大河内眞也、貫和敏博、渡辺彰、一ノ瀬正和
- Organizer
  第110回日本内科学会講演会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23390219
[Presentation] The enhancement of Stannniocalcin-1 (STC1) secretion of Multipotent-Stromal-Cells (MSCs) increases the ability to reduce bleomycin-induced lung injuries.2013
- Author(s)
  Manabu Ono*, Shinya Ohkouchi, Masahiko Kanehira, Naoki Tode, Makoto Kobayashi, Tadahisa Numakura, Toshiaki Kikuchi and Masakazu Ichinose.
- Organizer
  APSR (Asian Pacific Society of Respirology) Annual Meeting 2013
- Place of Presentation
  yokohama
- Data Source
  KAKENHI-PROJECT-24591149
[Presentation] STC1はUCP2誘導を介した過酸化ストレス軽減と非共役呼吸誘導をとおして、肺がん細胞の生存を誘導する2011
- Author(s)
  大河内眞也, 菊地利明, 海老名雅仁, 貫和敏博
- Organizer
  日本癌学会総会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2011-10-05
- Data Source
  KAKENHI-PROJECT-21590980
[Presentation] STC1はUCP2誘導を介した過酸化ストレス軽減と非共役呼吸誘導をとおして、肺がん細胞の生存を誘導する2011
- Author(s)
  大河内眞也、菊地利明、海老名雅仁、貫和敏博
- Organizer
  日本癌学会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2011-10-05
- Data Source
  KAKENHI-PROJECT-21590980
[Presentation] 間葉系幹細胞(MSCs)由来ミトコンドリア関連ホルモンSTC1を用いた肺微小環境恒常性維持の可能性2011
- Author(s)
  大河内眞也, 千葉茂樹, 菊地利明, 海老名雅仁, 貫和敏博
- Organizer
  第51回日本呼吸器学会学術講演会
- Place of Presentation
  東京
- Year and Date
  2011-04-22
- Data Source
  KAKENHI-PROJECT-23390219
[Presentation] Novel functions of stanniocalcin-1 (STC1) through uncoupling protein 2 (UCP2) up-regulation ; promoting survival of cancer cells under oxidative stress and inducing the uncoupling respiration (Warburg effect)2011
- Author(s)
  Ohkouchi S, Kikuchi T, Ebina M, Nukiwa T
- Organizer
  European Eespiratory Society Annual Congress
- Place of Presentation
  Amsterdam,オランダ
- Year and Date
  2011-09-24
- Data Source
  KAKENHI-PROJECT-23390219
[Presentation] Poster presentation ; Novel functions of stanniocalcin-1(STC1)through Uncoupling Protein 2(UCP2)up-regulation ; Promoting Survival of Cancer Cells under Oxidative Stress and Inducing the Uncoupling Respiration(Warburg effect)2011
- Author(s)
  Shinya Ohkouchi, Toshiaki Kikuchi, Masahito Ebina, Toshihiro Nukiwa
- Organizer
  欧州呼吸器学会年次集会
- Place of Presentation
  オランダ、アムステルダムREI
- Year and Date
  2011-09-25
- Data Source
  KAKENHI-PROJECT-21590980
[Presentation] Novel functions of stanniocalcin-1 (STC1) through Uncoupling Protein 2 (UCP2) upregulation ; Promoting Survival of Cancer Cells under Oxidative Stress and Inducing the Uncoupling Respiration (Warburg effect)2011
- Author(s)
  Shinya Ohkouchi, Toshiaki Kikuchi, Masahito Ebina, Toshihiro Nukiwa
- Organizer
  2011欧州呼吸器学会年次総会
- Place of Presentation
  アムステルダム、オランダ
- Year and Date
  2011-09-25
- Data Source
  KAKENHI-PROJECT-21590980
[Presentation] STC1はUCP2誘導を介した過酸化ストレス軽減と非共役呼吸誘導を通して肺がん細胞の生存を誘導する2011
- Author(s)
  大河内眞也, 菊地利明, 海老名雅仁, 貫和敏博
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2011-10-03
- Data Source
  KAKENHI-PROJECT-23390219
[Presentation] Multipotent Stromal Cell-Derived Stanniocalcin-1 Reduces Reactive Oxygen Species and Promotes Survival of Injured A549 Lung Epithelial Cancer Cells through Upregulation of Uncoupling-Protein 2 and Induction of the Warburg Effect2010
- Author(s)
  S.Ohkouchi, G.J.Block, D.J.Prockop, T.Nukiwa
- Organizer
  European Respiratory Society Annual Congress 2011
- Place of Presentation
  Bazcelona, Spain
- Year and Date
  2010-09-21
- Data Source
  KAKENHI-PROJECT-21590980
[Presentation] 間葉系幹細胞(MSCs)分泌Stanniocalcin1 (STC1)が誘導するUncouplingProtein2(UCP2)依存性ReactiveOxygenSpecies(ROS)抑制作用とWarburg効果2010
- Author(s)
  大河内眞也, Ahmed Katcha, 兼平雅彦, 菊地利明, 海老名雅仁, 貫和敏博
- Organizer
  第50回日本呼吸器学会総会
- Place of Presentation
  京都国際会議場
- Year and Date
  2010-04-21
- Data Source
  KAKENHI-PROJECT-21590980
[Presentation] 間葉系幹細胞(MSCs)分泌Stanniocalcin1(STC1)が誘導するUncouplingProtein2(UCP2)依存性ReactiveOxygenSpecies(ROS)抑制作用とWarburg効果2010
- Author(s)
  大河内眞也, ahmed Katcha, 兼平雅彦, 菊地利明, 海老名雅仁, 貫和敏博
- Organizer
  日本呼吸器学会学術総会
- Place of Presentation
  京都国際会議場
- Year and Date
  2010-04-21
- Data Source
  KAKENHI-PROJECT-21590980
[Presentation] Multipotent stromal cells(MSCs)secrete stanniocalcin-1(STC-1)and inhibit lung cancer cell death caused by ischemia.2009
- Author(s)
  Ohkouchi S, Nukiwa T
- Organizer
  第68回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2009-10-01
- Data Source
  KAKENHI-PROJECT-21590980
[Presentation] STANNIOCALCIN-1(STC1)DERIVED FROM BONE MULTIPOTENT STROM AL CELLS(MSCS)INHIBIT LUNG EPITHELIAL APOPTOSIS UNDER HYPO XIA AND LACTIC ACIDOSIS(MIMIC ISCHEMIA CONDITION).2009
- Author(s)
  Shinya Ohkouchi, Toshihiro Nukiwa
- Organizer
  14^<th> congress Asion Pacific Society of Respirology
- Place of Presentation
  Seaul, Korea
- Year and Date
  2009-11-16
- Data Source
  KAKENHI-PROJECT-21590980
[Presentation] Novel Functions Of Stanniocalcin-1(STC1) Through Uncoupling Protein 2 (UCP2) Up-Regulation; Promoting Survival Of Cancer Cells Under Oxidative Stress And Inducing The Uncoupling Respiration (Warburg Effect)
- Author(s)
  Shinya Ohkouchi
- Organizer
  ATS 2012
- Place of Presentation
  San Francisco, USA
- Data Source
  KAKENHI-PROJECT-24591149
[Presentation] The Enhancement Of Stannniocalcin-1 (STC1) Secretion Encourages The Abilities Of Mesenchymal Stem Cells (MSCs) Reducing Bleomycin Lung Injuries In Mice Model
- Author(s)
  Ono M, Ohkouchi S
- Organizer
  ATS2013
- Place of Presentation
  Philadelphia, USA
- Data Source
  KAKENHI-PROJECT-24591149
[Presentation] The enhancement of Stanniocalcin-1 (STC1) secretion increases the ability of mesenchymal stem cells (MSCs) to reduce bleomycin-induced lung fibrosis in a mouse model through inhibition of endoplasmic reticulum stress (ER-stress)/TGFbeta1 pathway
- Author(s)
  Shinya Ohkouchi, Manabu Ono and Masakazu Ichinose
- Organizer
  ERS international congress, 2014
- Place of Presentation
  Germany (Munich）
- Year and Date
  2014-09-06 – 2014-09-10
- Data Source
  KAKENHI-PROJECT-24591149

1. OKADA Yoshinori (90323104)

# of Collaborated Projects: 9 results

# of Collaborated Products: 0 results
2. KANEHIRA Masahiko (90374941)

# of Collaborated Projects: 8 results

# of Collaborated Products: 6 results
3. 大石久 (60451580)

# of Collaborated Projects: 8 results

# of Collaborated Products: 0 results
4. WATANABE Tatsuaki (70636034)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
5. Kurosawa Hajime (60333788)

# of Collaborated Projects: 4 results

# of Collaborated Products: 26 results
6. 野田雅史 (70400356)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
7. Irokawa Toshiya (70375179)

# of Collaborated Projects: 3 results

# of Collaborated Products: 19 results
8. KONDOH Takahshi (10195901)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. EBINA Masahito (10280885)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
10. INOUE Akira (70361087)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
11. Kikuchi Toshiaki (10280926)

# of Collaborated Projects: 2 results

# of Collaborated Products: 9 results
12. Ogawa Hiromasa (90361162)

# of Collaborated Projects: 2 results

# of Collaborated Products: 19 results
13. 松田安史 (00455833)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
14. 野津田泰嗣 (00636037)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
15. 平間崇 (80510338)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
16. 矢吹皓 (80848276)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
17. NUKIWA Toshihiro (40129036)

# of Collaborated Projects: 1 results

# of Collaborated Products: 18 results
18. SAIJO Yasuo (10270828)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
19. SATO Yasufumi (50178779)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. TAMADA Tsutomu (80396473)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. HISATA Shu (60466571)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. OHTA Hiromitsu (40451562)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. SADO Tetsu (20396485)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. Yamada Mitsuhiro (00396483)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. HATTORI Koichi (10360116)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 後藤昌史 (50400453)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 藤野直也 (10633670)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. 早坂一希 (40964739)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. 渡辺有為 (20724199)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. Dezawa Mari

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. HIROSE Masaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
32. Sugiura Hisatosi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
33. SAKATA Yasuhiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
34. 田澤立之

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
35. 中田光

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
36. 一ノ瀬正和

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
37. 井上義一

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
38. 東出直樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
39. 宮田敏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

OHKOUCHI Shinya 大河内 眞也

大河内 眞也 オオコウチ シンヤ

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Development of pro-inflammatory treatment by cross-sectional control of aging lung metabolism and epigeneticsPrincipal Investigator

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Elucidation of the pathophysiology of pulmonary fibrosis and development of new treatments by applying metabolome analysisPrincipal Investigator

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Differantial Mechanism of Lung Cells induced by Mesenchymal Stem Cells and the Treatment of Intractable Respiratory DiseasesPrincipal Investigator

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New Therapy for Intractable Pulmonary Fibrosis using Humoral Factors released from Mesenchymal Stem CellsPrincipal Investigator

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OHKOUCHI Shinya 大河内眞也

大河内眞也オオコウチシンヤ