HIRASHIMA MASANORI 平島正則

… Alternative Names

HIRASHIMA Masanori 平島正則

平島正則ヒラシママサノリ

Less

Researcher Number	40383757
Other IDs	https://orcid.org/0000-0002-0190-4381
Affiliation (Current)	2025: 新潟大学, 医歯学系, 教授
Affiliation (based on the past Project Information) *help	2020 – 2024: 新潟大学, 医歯学系, 教授 2018: 神戸大学, 医学研究科, 非常勤講師 2016 – 2017: 神戸大学, 医学研究科, 准教授 2012 – 2015: 神戸大学, 医学(系)研究科(研究院), 准教授 2012: 神戸大学, 大学院・医学研究科, 准教授 … More 2010 – 2012: 神戸大学, 医学研究科, 准教授 2010: 神戸大学, 大学院・医学研究科, 准教授 2007: Kobe University, 医学系研究科, 准教授 2006: 慶應義塾大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Biomedical structure and function and related fields / General anatomy (including histology/embryology) / Biological Sciences / General anatomy (including Histology/Embryology) / Developmental biology / Biological Sciences Except Principal Investigator Basic Section 56070:Plastic and reconstructive surgery-related / Basic Section 48010:Anatomy-related / Basic Section 54010:Hematology and medical oncology-related / Plastic surgery / General medical chemistry
Keywords	Principal Investigator 発生・分化 / 遺伝子変異 / マウス / 遺伝子 / リンパ管 / 胎生期浮腫 / 発生 / 動物 / 細胞・組織 / 解剖学 … More / 疾患モデル / 胎児 / 管腔形成 / 血管 / 形態形成学 / 発生学 … More Except Principal Investigator 血小板 / リンパ浮腫 / リンパ管 / リンパ管内皮細胞 / リンパ節 / siRNA / 臨床モデル / リンパ管静脈吻合 / マウス / 血管 / リンパ洞フィルター / 細胞間相互作用 / 免疫応答 / 組織マクロファージ / 間質ストローマ細胞 / 抗体産生 / T細胞応答 / リンパ液フィルター / ストローマ細胞 / マクロファージ / リンパ洞 / 発生 / CLEC-2 / 異所性リンパ組織 / リンパ節発生 / ポドプラニン / プロスタノイド受容体 / プロスタノイド / マイクロサージェリー学 / 癲癇 / Rapl / 癩癇 / 雄性不妊 / 精子形成異常 / 帯状異所性灰白質症 / 神経細胞移動 / 血管形成 / ノックアウトマウス / グアニンヌクレオチド交換因子 / Rap1 / 低分子量G蛋白質 Less

マイクロサージェリーを用いないリンパ浮腫の外科治療を開発する
- Principal Investigator
  
  田中宏明
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56070:Plastic and reconstructive surgery-related
- Research Institution
  Niigata University
リンパ管・血管分離を維持する血小板放出因子の作用機序
- Principal Investigator
  
  椎谷友博
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48010:Anatomy-related
- Research Institution
  Niigata University
血小板とリンパ管内皮細胞の相互作用を標的にした新たなリンパ浮腫治療の開発
- Principal Investigator
  
  植木春香
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56070:Plastic and reconstructive surgery-related
- Research Institution
  Niigata University
Molecular/cellular basis of lymphatic sinus filter in lymph node
- Principal Investigator
  
  Katakai Tomoya
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 48010:Anatomy-related
- Research Institution
  Niigata University
A role of platelets in lymphoid tissue development: platelets as a cargo of bioactive substances
- Principal Investigator
  
  Suzuki-INoue Katsue
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  University of Yamanashi
A novel screen for mouse models of embryonic diseasePrincipal Investigator
- Principal Investigator
  
  HIRASHIMA MASANORI
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Research Field
  
  Biomedical structure and function and related fields
- Research Institution
  Kobe University
Developmental mechanism and functional significance of physiological lymphovenous anastomosis.Principal Investigator
- Principal Investigator
  
  Hirashima Masanori
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General anatomy (including histology/embryology)
- Research Institution
  Kobe University
リンパ管腔形成と維持におけるＡｓｐｐ１の役割と分子機構Principal Investigator
- Principal Investigator
  
  平島正則
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Kobe University
Pathology and molecular mechanism of embryonic edema in mice carrying endothelial gene mutationsPrincipal Investigator
- Principal Investigator
  
  HIRASHIMA Masanori
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General anatomy (including Histology/Embryology)
- Research Institution
  Kobe University
Analysis of prostanoid receptors on lymphatic vessels
- Principal Investigator
  
  NOMURA Tadashi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Plastic surgery
- Research Institution
  Kobe University
Analysis of the function of Rap1-activating factors which mediate the cross-talks between different species of small G proteins
- Principal Investigator
  
  KATAOKA Tohru
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Kobe University
血管内皮細胞の動・静脈アイデンティティーを決定する細胞外環境Principal Investigator
- Principal Investigator
  
  平島正則
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kobe University
  Keio University
マウス胚における動・静脈形成Principal Investigator
- Principal Investigator
  
  平島正則
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Developmental biology
- Research Institution
  Kobe University
  Keio University

All 2023 2022 2018 2017 2016 2014 2013 2012 2011 2010 2009

All Journal Article Presentation

[Journal Article] From lymphatic endothelial cell migration to formation of tubular lymphatic vascular network2023
- Author(s)
  Shiiya Tomohiro、Hirashima Masanori
- Journal Title
  
  Frontiers in Physiology
  
  Volume: 14
- DOI
  10.3389/fphys.2023.1124696
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06788
[Journal Article] Semaphorin 3G provides a repulsive guidance cue to lymphatic endothelial cells via Neuropilin-2/PlexinD1.2016
- Author(s)
  Liu X, Uemura A, Fukushima Y, Yoshida Y, Hirashima M.
- Journal Title
  
  Cell Rep
  
  Volume: 17 Issue: 9 Pages: 2299-2311
- DOI
  10.1016/j.celrep.2016.11.008
- NAID
  120005970748
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460253, KAKENHI-PROJECT-15K20260
[Journal Article] Flt1/VEGFR1 heterozygocity causes transient embryonic edema2016
- Author(s)
  Otowa Y, Moriwaki K, Sano K, Shirakabe M, Yonemura S, Shibuya M, Rossant J, Suda T, Kakeji Y, Hirashima M
- Journal Title
  
  Scientific Report
  
  Volume: 6 Issue: 1 Pages: 27186-27186
- DOI
  10.1038/srep27186
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26221309, KAKENHI-PROJECT-26460253, KAKENHI-PROJECT-16K20009
[Journal Article] Flt1 and Flk1 mediate regulation of intraocular pressure and their double heterozygosity causes the buphthalmia in mice2012
- Author(s)
  Keigo Sano, Osamu Katsuta, Satoshi Shirae, Yoshiaki Kubota, Masatsugu Ema, Toshio Suda, Masatsugu Nakamura, Masanori Hirashima
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590173
[Journal Article] Flt1 and Flk1 mediate regulation of intraocular pressure and their double heterozygosity causes the buphthalmia in mice2012
- Author(s)
  Keigo Sano, Osamu Katsuta, Satoshi Shirae, Yoshiaki Kubota, Masatsugu Ema, Toshio Suda, Masatsugu Nakamura and Masanori Hirashima
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 420(2) Issue: 2 Pages: 422-427
- DOI
  10.1016/j.bbrc.2012.03.011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590173
[Journal Article] Impaired vascular development in the yolk sac and allantois in mice lacking RA-GEF-1.2009
- Author(s)
  Kanemura, H., Satoh, T., Bilasy, S.E., Ueda, S., Hirashima, M., Kataoka, T.
- Journal Title
  
  Biochem.Biophys.Res.Comm. 387
  
  Pages: 754-759
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390080
[Presentation] TGF-βは血小板を介したリンパ管と血管の分離にはたらく2022
- Author(s)
  〇椎谷友博、劉シンイ、杉山彰、吉松康裕、平島正則
- Organizer
  第96回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-22K06788
[Presentation] Lymphatic vascular development and embryonic edema in mice.2018
- Author(s)
  平島　正則
- Organizer
  第40回日本血栓止血学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-17K19526
[Presentation] リンパ管パターニングに関わるSemaphorin/Plexinシグナル2017
- Author(s)
  平島正則
- Organizer
  第122回日本解剖学会総会・全国学術集会
- Place of Presentation
  長崎大学坂本キャンパス（長崎県長崎市）
- Year and Date
  2017-03-28
- Invited
- Data Source
  KAKENHI-PROJECT-26460253
[Presentation] リンパ管パターニングに関わるSemaphorin/Plexinシグナル2016
- Author(s)
  平島正則
- Organizer
  第40回日本リンパ学会総会
- Place of Presentation
  東京大学伊藤国際学術研究センター（東京都文京区）
- Year and Date
  2016-06-24
- Invited
- Data Source
  KAKENHI-PROJECT-26460253
[Presentation] Semaphorin 3G provides a repulsive guidance cue from arteries to Plexin D1+ lymphatic endothelial cells in mouse embryonic skin.2016
- Author(s)
  Liu X, Uemura A, Fukushima Y, Yoshida Y, Hirashima M.
- Organizer
  第24回日本血管生物医学会学術集会
- Place of Presentation
  長崎ブリックホール（長崎県長崎市）
- Year and Date
  2016-12-08
- Data Source
  KAKENHI-PROJECT-26460253
[Presentation] Platelet activation blocks misconnection of lymphatic to blood vessels in mouse peripheral tissues by promoting lymphatic endothelial cell retraction via TGF-β signals.2016
- Author(s)
  平島　正則
- Organizer
  第89回日本薬理学会年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-03-09
- Invited
- Data Source
  KAKENHI-PROJECT-26460253
[Presentation] Aspp1 plays a crucial role in lymphatic vascular fusion and lymph-venous connection during mouse embryogenesis2014
- Author(s)
  Kenta Mukai, Xinyi Liu, Kazumasa Moriwaki, Daiki Ikeda, Takashi Ueda, Masanori Hirashima
- Organizer
  The 18th International Vascular Biology Meeting
- Place of Presentation
  みやこめっせ（京都）
- Data Source
  KAKENHI-PUBLICLY-24112513
[Presentation] Aspp1ノックアウトマウスにみられる胎生期浮腫とリンパ管形成異常2014
- Author(s)
  平島　正則
- Organizer
  第38回日本リンパ学会総会
- Place of Presentation
  北里大学白金キャンパス薬学部コンベンションホール
- Year and Date
  2014-06-21
- Invited
- Data Source
  KAKENHI-PROJECT-26460253
[Presentation] リンパ管腔形成と維持におけるAspp1の役割2013
- Author(s)
  平島　正則
- Organizer
  平成 24 年度文部科学省新術領域研究がん研究分野の特性等を踏まえた支援活動公開シンポジウム
- Place of Presentation
  学術総合センター（東京都）
- Year and Date
  2013-01-29
- Data Source
  KAKENHI-PUBLICLY-24112513
[Presentation] Aspp1 plays a crucial role in lymphatic vascular fusion and lymph-venous connection during mouse embryogenesis2013
- Author(s)
  Masanori Hirashima,　Xinyi Liu,　Kazumasa Moriwaki,　Daiki Ikeda
- Organizer
  1st International Meeting for Epithelial Tubulology
- Place of Presentation
  北海道大学学術交流会館（札幌）
- Data Source
  KAKENHI-PUBLICLY-24112513
[Presentation] Aspp1 plays a crucial role in lymphatic vascular fusion and lymph-venous connection during mouse embryogenesis2013
- Author(s)
  Masanori Hirashima,　Kenta Mukai, Xinyi Liu,　Kazumasa Moriwaki,　Daiki Ikeda
- Organizer
  第21回日本血管生物医学会学術集会
- Place of Presentation
  千里阪急ホテル（大阪）
- Data Source
  KAKENHI-PUBLICLY-24112513
[Presentation] 血小板はどのようにしてリンパ管網の独自性を守るのか2012
- Author(s)
  平島　正則
- Organizer
  日本リンパ学会
- Place of Presentation
  東京女子医科大学（東京都）
- Invited
- Data Source
  KAKENHI-PROJECT-22590173
[Presentation] 血小板はどのようにしてリンパ管網の独自性を守るのか2012
- Author(s)
  平島正則
- Organizer
  第36回日本リンパ学会総会「シンポジウム・リンパ管の形成・機能の発現を左右する重要因子
- Place of Presentation
  東京女子医科大学(東京都)
- Year and Date
  2012-06-29
- Data Source
  KAKENHI-PROJECT-22590173
[Presentation] Platelets Contribute to the Separation between Blood Vessels and Lymphatic Vessels during Lymphatic Sprouting2011
- Author(s)
  Guo Ding, Katsue Suzuki Inoue, Osamu Inoue, Masaki Hikida, Tomohiro Kurosaki, Masanori Hirashima
- Organizer
  第19回日本血管生物医学会学術集会
- Place of Presentation
  東京ステーションコンファレンス(東京都)
- Year and Date
  2011-12-09
- Data Source
  KAKENHI-PROJECT-22590173
[Presentation] Platelets Contribute to the Separation between Blood Vessels and Lymphatic Vessels during Lymphatic Sprouting2011
- Author(s)
  Guo Ding, Katsue Suzuki Inoue, Osamu Inoue, Masaki Hikida, Tomohiro Kurosaki, Masanori Hirashima
- Organizer
  日本血管生物医学会
- Place of Presentation
  東京ステーションコンファレンス(東京都)
- Year and Date
  2011-12-09
- Data Source
  KAKENHI-PROJECT-22590173
[Presentation] 体液調節異常と胎生期浮腫をきたす遺伝子変異マウスの解析2010
- Author(s)
  平島正則
- Organizer
  日本人類遺伝学会第55回大会
- Place of Presentation
  大宮ソニックシティ(埼玉県)
- Year and Date
  2010-10-29
- Data Source
  KAKENHI-PROJECT-22590173
[Presentation] 体液調節異常と胎生期浮腫をきたす遣伝子変異マウスの解析2010
- Author(s)
  平島正則
- Organizer
  日本リンパ学会
- Place of Presentation
  東京大学山上会館(東京都)(招待講演)
- Year and Date
  2010-06-26
- Data Source
  KAKENHI-PROJECT-22590173
[Presentation] 体液調節異常と胎生期浮腫をきたす遺伝子変異マウスの解析2010
- Author(s)
  平島正則
- Organizer
  日本人類遺伝学会
- Place of Presentation
  大宮ソニックシティ(埼玉県)
- Year and Date
  2010-10-29
- Data Source
  KAKENHI-PROJECT-22590173
[Presentation] VEGF-A receptors in lymphatic vessel development and fluid homeostasis2010
- Author(s)
  Masanori Hirashima
- Organizer
  2010 International Cancer Biology Symposium
- Place of Presentation
  国立中山大学(台湾)(招待講演)
- Year and Date
  2010-06-28
- Data Source
  KAKENHI-PROJECT-22590173
[Presentation] 体液調節異常と胎生期浮腫をきたす遺伝子変異マウスの解析2010
- Author(s)
  平島正則
- Organizer
  第34回日本リンパ学会総会「シンポジウム・リンパ管新生の最前線」
- Place of Presentation
  東京大学山上会館(東京都)
- Year and Date
  2010-06-26
- Data Source
  KAKENHI-PROJECT-22590173
[Presentation] VEGF-A receptors in lymphatic vessel development and fluid homeostasis2010
- Author(s)
  Masanori Hirashima
- Organizer
  2010 International Cancer Biology Symposium
- Place of Presentation
  国立中山大学(台湾)
- Year and Date
  2010-06-28
- Data Source
  KAKENHI-PROJECT-22590173

1. 椎谷友博 (80613190)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
2. 田中宏明 (80965260)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. 松田健 (50423166)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. LIU Xinyi

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
5. KATAOKA Tohru (40144472)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. SATOH Takaya (20251655)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. SHIMA FUMI (60335445)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. EDAMATSU Hironori (70335438)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. MORIWAKI Kazumasa (00467656)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. DING Guo (00514697)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
11. NOMURA Tadashi (30529566)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. HASHIKAWA Kazunobu (90403237)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. TERASHI Hiroto (80217421)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. SAKAKIBARA Shunsuke (50444592)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. Suzuki-INoue Katsue (10324211)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. Katakai Tomoya (00324682)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 田原真也 (60207206)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 若菜茂晴 (90192434)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 田村勝 (50370119)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 築地長治 (20710362)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 佐々木知幸 (40739124)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 白井俊光 (50710381)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 奥田修二郎 (00512310)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 植木春香 (10899933)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. OTOWA Yasunori

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. MUKAI Kenta

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. UETA Koji

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. OGASAWARA Rina

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. 須田年生

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HIRASHIMA MASANORI 平島 正則

HIRASHIMA Masanori 平島 正則

平島 正則 ヒラシマ マサノリ

Research Projects

Research Products

Co-Researchers

マイクロサージェリーを用いないリンパ浮腫の外科治療を開発する

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

リンパ管・血管分離を維持する血小板放出因子の作用機序

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

血小板とリンパ管内皮細胞の相互作用を標的にした新たなリンパ浮腫治療の開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular/cellular basis of lymphatic sinus filter in lymph node

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

A role of platelets in lymphoid tissue development: platelets as a cargo of bioactive substances

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

A novel screen for mouse models of embryonic diseasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Developmental mechanism and functional significance of physiological lymphovenous anastomosis.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

リンパ管腔形成と維持におけるＡｓｐｐ１の役割と分子機構Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Pathology and molecular mechanism of embryonic edema in mice carrying endothelial gene mutationsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of prostanoid receptors on lymphatic vessels

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of the function of Rap1-activating factors which mediate the cross-talks between different species of small G proteins

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

血管内皮細胞の動・静脈アイデンティティーを決定する細胞外環境Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

マウス胚における動・静脈形成Principal Investigator

Principal Investigator

HIRASHIMA MASANORI 平島正則

HIRASHIMA Masanori 平島正則

平島正則ヒラシママサノリ