Nomura Miyuki 野村美有樹

… Alternative Names

野村美有樹ノムラミユキ

NOMURA Miyuki 野村美有樹

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Researcher Number	40390893
Other IDs
Affiliation (Current)	2025: 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん薬物療法研究部, 研究技師
Affiliation (based on the past Project Information) *help	2018: 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん薬物療法研究部, 研究技師 2017: 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), その他部局等, その他 2010: 宮城県立がんセンター(研究所), 薬物療法学部, 技師 2008 – 2009: 宮城県立がんセンター研究所, 薬物療法学部, 技師 2007 – 2008: 宮城県立がんセンター(研究所), 薬物療法学部, 技師 2006: 宮城県立がんセンター(研究所), 技師 2006: Miyagi Cancer Center Research Institute, Division of Cancer Chemotherapy, Staff, 薬物療法学部, 技官
Review Section/Research Field	Principal Investigator Obstetrics and gynecology Except Principal Investigator Functional biochemistry / Thoracic surgery / Cerebral neurosurgery
Keywords	Principal Investigator 婦人科腫瘍学 / PP6 / 卵巣がん / BRCA / プロテインホスファターゼ6型 / BRCA1 / プロテインホスファターゼ Except Principal Investigator スプライシング / PP1 / MKP7 … More / LDP4 / プロテインホスファターゼ / pp32 / PP2A / SET / I-2^<PP2A> / I-1^<PP2A> / TCPTP / 組織バンク / 肺癌 / NIPP1 / Aurora kinase / siRNA / 浸透圧刺激 / LDP / ユビキチン / MAPKホスファターゼ / MAPK / 中心体 / ビメンチン / 阻害剤 / manzamenone / PTP1B / T-cell PTP / オーロラキナーゼ / モノクロナル抗体 / 低酸素 / 遺伝子発現 / ワールブルグ効果 / 解糖系酵素 / 診断法 / 化学療法 / 脳腫瘍学 / ERK / 中心体制御 / PP6 / β-catenin / N-Cadherin / KIF3A / Dusp26 / 細胞死 / モータータンパク / 細胞間接着 / 癌 / DUSP26 / SAP155 / HRM / 早期肺癌 / 前癌病変 / 遺伝子変異 / 遺伝子発現異常 / MAPK経路 / KIF3モーター / 細胞内トランスポート / 呼吸器外科学 / mRNA / クロマチンリモデリング活性 / 結合蛋白 / クロマチン免疫沈降法 / FHAドメイン / 翻訳 / 転写 Less

A protein phosphatase, which is involved BRCA1 dependent DNA repair.Principal Investigator
- Principal Investigator
  
  Nomura Miyuki
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Miyagi Prefectural Hospital Organization Miyagi Cancer Center
解糖系異常亢進を惹起する肺癌特異的スプライシングスイッチング‐新規診断法の開発‐
- Principal Investigator
  
  佐藤雅美
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Thoracic surgery
- Research Institution
  Kagoshima University
  Miyagi Cancer Center Research Institute
Therapeutic effect of the polymeric micellar antineoplastic drugs infused convection-enhanced delivery against intracranial rat glioma models
- Principal Investigator
  
  YAMASHITA Yoji
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Miyagi Cancer Center Research Institute
Development of genetic diagnosis and drugs for lung cancer, based on protein phosphatase targeting
- Principal Investigator
  
  SATO Masami
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Thoracic surgery
- Research Institution
  Miyagi Cancer Center Research Institute
Regulation of cell function by protein phosphatases
- Principal Investigator
  
  SHIMA Hiroshi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  Miyagi Cancer Center Research Institute
mRNA翻訳効率に対する転写過程での刷り込み現象
- Principal Investigator
  
  SHIMA Hiroshi
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Functional biochemistry
- Research Institution
  Miyagi Cancer Center Research Institute
Regulation of cell function by protein dephosphorylation
- Principal Investigator
  
  SHIMA Hiroshi
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  Miyagi Cancer Center Research Institute
  Hokkaido University

All 2018 2017 2010 2009 2008 2007 2006

All Journal Article Presentation

[Journal Article] A metabolic vulnerability of small-cell lung cancer2018
- Author(s)
  Nomura Miyuki、Morita Mami、Tanuma Nobuhiro
- Journal Title
  
  Oncotarget
  
  Volume: 9 Issue: 64 Pages: 32278-32279
- DOI
  10.18632/oncotarget.25964
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K16876, KAKENHI-PROJECT-17K07231, KAKENHI-PROJECT-17K19620
[Journal Article] Revisiting glucose metabolism in cancer: lessons from a PKM knock-in model2018
- Author(s)
  Sato Taku、Morita Mami、Nomura Miyuki、Tanuma Nobuhiro
- Journal Title
  
  Molecular & Cellular Oncology
  
  Volume: 5 Issue: 4 Pages: e1472054-e1472054
- DOI
  10.1080/23723556.2018.1472054
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K16876
[Journal Article] Loss of protein phosphatase 6 in mouse keratinocytes enhances K-rasG12D-driven tumor promotion.2018
- Author(s)
  Kurosawa K, Inoue Y, Kakugawa Y, Yamashita Y, Kanazawa K, Kishimoto K, Nomura M, Momoi Y, Sato I, Chiba N, Suzuki M, Ogoh H, Yamada H, Miura K, Watanabe T, Tanuma N, Tachi M, and Shima H
- Journal Title
  
  Cancer Science
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K16876
[Journal Article] Loss of protein phosphatase 6 in mouse keratinocytes enhances K-ras G12D -driven tumor promotion2018
- Author(s)
  Kurosawa Koreyuki、Inoue Yui、Kakugawa Yoichiro、Yamashita Yoji、Kanazawa Kosuke、Kishimoto Kazuhiro、Nomura Miyuki、Momoi Yuki、Sato Ikuro、Chiba Natsuko、Suzuki Mai、Ogoh Honami、Yamada Hidekazu、Miura Koh、Watanabe Toshio、Tanuma Nobuhiro、Tachi Masahiro、Shima Hiroshi
- Journal Title
  
  Cancer Science
  
  Volume: 109 Issue: 7 Pages: 2178-2187
- DOI
  10.1111/cas.13638
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07187, KAKENHI-PROJECT-17K10660, KAKENHI-PROJECT-18K16043, KAKENHI-PROJECT-16H04690, KAKENHI-PROJECT-16K07296, KAKENHI-PROJECT-16K10486, KAKENHI-PROJECT-16K10774, KAKENHI-PROJECT-17K16358, KAKENHI-PROJECT-17K16876, KAKENHI-PROJECT-18K09243, KAKENHI-PROJECT-16K07187, KAKENHI-PROJECT-17K19620
[Journal Article] Ex vivo model of non-small cell lung cancer using mouse lung epithelial cells.2017
- Author(s)
  Sato T, Morita M, Tanaka R, Inoue Y, Nomura M, Sakamoto Y, Miura K, Ito S, Sato I, Tanaka N, Abe J, Takahashi S, Kawai M, Sato M, Hippo Y, Shima H, Okada Y, Tanuma N
- Journal Title
  
  Oncol Lett.
  
  Volume: 14(6) Pages: 6863-6868
- DOI
  10.3892/ol.2017.7098
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K10486, KAKENHI-PROJECT-17K07187, KAKENHI-PROJECT-17K10660, KAKENHI-PROJECT-17K10796, KAKENHI-PROJECT-17K19620, KAKENHI-PROJECT-17K19624, KAKENHI-PROJECT-17K16876, KAKENHI-PROJECT-16K19745
[Journal Article] CDC25A mRNA levels significantly correlate with Ki-67 expression in human glioma samples.2010
- Author(s)
  Yamashita Y, Kasugai I, Sato M, Tanuma N, Sato I, Nomura M, Yamashita K, Sonoda Y, Kumabe T, Tominaga T, Katakura R, Shima H
- Journal Title
  
  J Neurooncol 100
  
  Pages: 43-49
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591730
[Journal Article] MKP-7, a JNK phosphatase, blocks ERK-dependent gene activation by anchoring phosphorylated ERK in the cytoplasm.2010
- Author(s)
  Masuda K, Katagiri C, Nomura M, Sato M, Kakumoto K, Akagi T, Kikuchi K, Tanuma N, Shima H.
- Journal Title
  
  Biochem Biophys Res Commun 393
  
  Pages: 201-206
- Data Source
  KAKENHI-PROJECT-19390370
[Journal Article] Protein phosphatase Dusp26 associates with KIF3 motor and promotes N-cadherin-mediaded cell-cel adhesion.2009
- Author(s)
  Tanuma N, Nomura M, Ikdea M, Kusugai I, Tsubaki Y, Takagaki K, Kawamura T, Yamashita Y, Sato I, Sato M, Katakura R, Kikuchi K, Shima H
- Journal Title
  
  Oncogene 28
  
  Pages: 752-76
- Data Source
  KAKENHI-PROJECT-19390370
[Journal Article] Protein phosphatase Dusp26 associates with KIF3 motor and promotes N-cadherin-mediated cell-cell adhesion.2009
- Author(s)
  Tanuma N, Nomura M, Ikeda M, Kasugai I, Tsubaki Y, Takagaki K, Kawamura T, Yamashita Y, Sato I, Sato M, Katakura R, Kikuchi K, Shima H
- Journal Title
  
  Oncogene 28
  
  Pages: 752-761
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591730
[Journal Article] Protein phosphatase Dusp26 associates with KIF3 motor and promotes N-cadherin-mediated cell-cell adhesion.2009
- Author(s)
  Tanuma N, Nomura M, Ikeda M, Kasugai I, Tsubaki Y, Takagaki K,Kawamura T, Yamashita Y, Sato I, Sato M, Katakura R, Kikuchi K, Shima H.
- Journal Title
  
  Oncogene 28
  
  Pages: 752-761
- Data Source
  KAKENHI-PROJECT-19570142
[Journal Article] Nuclear inhibitor of protein phosphatase-1 (NIPP1) directs protein phosphatase-1(PP1) to dephosphorylate the U2 small nuclesr ribonucleoprotein particle(snRNP)component2008
- Author(s)
  Tanuma N, Kim SE, Buellens M, Tsubaki Y, Mitsuhashi S, Nomura M, Kawamura T, Isono K, Koseki H, Sato M, Bollen M, Kikuchi K, Shima H
- Journal Title
  
  spliceosome-associated protein 155 (Sap155). J Biol Chem 52
  
  Pages: 35805-35814
- Data Source
  KAKENHI-PROJECT-19390370
[Journal Article] Nuclear inhibitor of protein phosphatase-1 (NIPP1) directs protein phosphatase-1 (PP1) to dephosphorylatethe U2 snRNP component, spliceosome-associated protein 155 (Sap155)2008
- Author(s)
  Tanuma N, Kim S-E, Beullens M, Tsubaki Y, Mitsuhashi S, Nomura M, Kawamura T, Isono K, Koseki H, Sato M, Bollen M, Kikuchi K, Shima H.
- Journal Title
  
  Journal of Biological Chemistry 283(51)
  
  Pages: 35805-35814
- Data Source
  KAKENHI-PROJECT-19570142
[Journal Article] Characterization of a novel low-molecular-mass dual specificity phosphatase-4 (LDP-4) expressed in brain.2007
- Author(s)
  Takagaki K, Shima H, Tanuma N, Nomura M, Satoh T, Watanabe M, Kikuchi K.
- Journal Title
  
  Molecular and Cellular Biochemistry 296(1-2)
  
  Pages: 177-84
- Data Source
  KAKENHI-PROJECT-19570142
[Journal Article] Characterization of a novel low-molecular- mass dual specificity phosphatase-4(LDP-4) expressed in brain2006
- Author(s)
  Takagaki K, Shima H, Tanuma N, Nomura M, Satoh T, Watanabe M, Kikuchi K.
- Journal Title
  
  Mol Cell Biochem 296
  
  Pages: 177-184
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16370055
[Presentation] 13Cグルコースを使ったマウス個体でのin vivoトレーサー解析2018
- Author(s)
  田沼延公,、野村美有樹、福原達郎、坂本良美、島礼、本橋ほづみ、紙健次郎
- Organizer
  生化学会東北支部会
- Data Source
  KAKENHI-PROJECT-17K16876
[Presentation] 活性型Ｐｋｍ1－Ｐｋｍ２ヘテロ複合体の形成2018
- Author(s)
  野村美有樹、盛田麻美、坂本良美、島礼、田沼延公
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K16876
[Presentation] Pkm1 とPkm2 の機能解析-非小細胞肺がん（NSCLC）での検討2017
- Author(s)
  野村美有樹、佐藤卓、盛田麻美、坂本良美、田中遼太、三浦康、河合賢朗、佐藤郁郎、島礼、田沼延公
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K16876
[Presentation] 肺神経内分泌腫瘍（NET）における治療標的候補としてのPkm12017
- Author(s)
  盛田麻美、野村美有樹、坂本良美、佐藤卓、田中遼太、福原達朗、佐藤郁郎、中山敬一、前門戸任、島礼、田沼延公
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K16876
[Presentation] Ppp6c は、マウス皮膚のがん抑制遺伝子として働く2017
- Author(s)
  黒沢是之、野村美有樹、角川陽一郎、山下洋二、三浦康、山田秀和、松浦一登、佐藤郁郎、田沼延公、渡邊利雄、島礼
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K16876
[Presentation] Dusp26 Associates with KIF3 Motor and Promotes Cadherin-Mediated Cell-Cell Adhesion EUROPHOSPHATASE 20092009
- Author(s)
  Miyuki Nomura, Nobuhiro Tanuma, Isao Kasugai, Masami Sato, Hiroshi Shima
- Organizer
  Protein phosphatases in development and disease, Egmond aan Zee
- Place of Presentation
  The Netherlands
- Year and Date
  2009-07-16
- Data Source
  KAKENHI-PROJECT-19390370
[Presentation] プロテインホスファターゼPP1/NIPP1複合体によるSap155/Sf3b1の脱リン酸化とsplicing制御機構2008
- Author(s)
  田沼延公、椿耶緒、野村美有樹、菊池九二三、島礼
- Organizer
  BMB2008第31回日本分子生物学会第81回日本生化学会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-19570142
[Presentation] ホスファターゼPP1-NIPP1ホロ酵素によるU2snRNPのSap155/Sf3b1サブユニットの脱リン酸化 Phosphatase PP1-NIPP1 holoenzyme de-phosphorylates Sap155/Sf3b1 of U2snRNP2008
- Author(s)
  田沼延公、野村美有樹、島礼
- Organizer
  第67回日本癌学会総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-19570142
[Presentation] PP1/NIPP1複合体によるU2snRNPのSap155/Sf3b1構成タンパク、Sap155/Sf3b1の脱リン酸化2008
- Author(s)
  田沼延公、椿耶緒、野村美有樹、菊池九二三、島礼
- Organizer
  BMB2008第31回日本分子生物学会第81回日本生化学会合同大会シンポジウム「3S22ホスファターゼスーパーファミリーの機能と異常:ゲノムから疾患まで」
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-19570142
[Presentation] DUSP26によるキネシンモーターKIF3の制御およびCadherin 依存性細胞接着の亢進2008
- Author(s)
  野村美有樹、田沼延公、池田正稔、春日井勲、菊池九二三、島礼
- Organizer
  BMB2008第31回日本分子生物学会第81回日本生化学会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-19570142
[Presentation] DUSP26はKIF3Aと結合しKAP3の脱リン酸化を促進する2008
- Author(s)
  野村美有樹、田沼延公、高垣謙太郎、島礼
- Organizer
  第67回日本癌学会総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-19570142
[Presentation] NIPP1-PP1cホロ酵素によるU2snRNPコンポーネントSap155/SF3b1の脱リン酸化2007
- Author(s)
  田沼延公,金世殷,椿耶緒,島礼,三橋進也,野村美有樹,菊池九二三
- Organizer
  BMB2007第30回日本分子生物学会第80回日本生化学会合同大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19570142
[Presentation] Low-molecular-mass dual specificity phosphatase-4(LDP-4) functions as an activator of JNK and p38.2007
- Author(s)
  野村美有樹、高垣謙太郎、田沼延公、菊池九二三、島礼
- Organizer
  第66回日本癌学会総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19570142
[Presentation] LDP-4, a cancer-associated dual-specificity protein phosphatase binds kinesine2007
- Author(s)
  田沼延公、高垣謙太郎、野村美有樹、菊池九二三、島礼
- Organizer
  第66回日本癌学会総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19570142
[Presentation] Characterization of LDP-4, a cancer-associated dual-specificity phosphatase2007
- Author(s)
  Miyuki Nomura, Kentaro Takagaki, Nobuhiro Tanuma, Kumimi Kikuchi, Hiroshi Shima
- Organizer
  EUROPHOSPHATASES 2007, Protein Phosphatases in Health and Disease
- Place of Presentation
  Aveiro, Portugal
- Data Source
  KAKENHI-PROJECT-19570142
[Presentation] 二重基質特異性ホスファターゼLDP-4とキネシンの結合2007
- Author(s)
  野村美有樹,田沼延公,高垣謙太郎,菊池九二三,島礼
- Organizer
  BMB2007第30回日本分子生物学会第80回日本生化学会合同大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19570142
[Presentation] Function of MKP-7, at chromosome 12p, towards MAPK cascade2007
- Author(s)
  Hiroshi Shima, Chiaki Katagiri, Kouhei Masuda, Miyuki Nomura, Isao Kasugai, Nobuhiro Tanuma
- Organizer
  Mechanisms and Models of Cancer Meeting
- Place of Presentation
  San Diego
- Data Source
  KAKENHI-PROJECT-19570142
[Presentation] PP1 de-regulation by a mutant form of NIPP1 lacking the C-terminal region2007
- Author(s)
  Nobuhiro Tanuma, Shinya Mitsuhashi, Miyuki Nomura, Yao Tsubaki, Sei-Eun Kim, Kunimi Kikuchi, Hiroshi Shima
- Organizer
  EUROPHOSPHATASES 2007, Protein Phosphatases in Health and Disease
- Place of Presentation
  Aveiro, Portugal
- Data Source
  KAKENHI-PROJECT-19570142

1. TANUMA Nobuhiro (40333645)

# of Collaborated Projects: 6 results

# of Collaborated Products: 22 results
2. SHIMA Hiroshi (10196462)

# of Collaborated Projects: 5 results

# of Collaborated Products: 24 results
3. KIKUCHI Kunimi (20006117)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
4. SATO Masami (30250830)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
5. SASAKI Nozomi (50467429)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. YAMASHITA Yoji (30420045)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
7. YOKOYAMA Masayuki (20220577)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. SONODA Yukihiko (90302140)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. KAWAI Masaaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 佐藤郁郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Nomura Miyuki 野村 美有樹

野村 美有樹 ノムラ ミユキ

NOMURA Miyuki 野村 美有樹

Research Projects

Research Products

Co-Researchers

A protein phosphatase, which is involved BRCA1 dependent DNA repair.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

解糖系異常亢進を惹起する肺癌特異的スプライシングスイッチング‐新規診断法の開発‐

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Therapeutic effect of the polymeric micellar antineoplastic drugs infused convection-enhanced delivery against intracranial rat glioma models

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of genetic diagnosis and drugs for lung cancer, based on protein phosphatase targeting

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Regulation of cell function by protein phosphatases

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

mRNA翻訳効率に対する転写過程での刷り込み現象

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Regulation of cell function by protein dephosphorylation

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] A metabolic vulnerability of small-cell lung cancer2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Revisiting glucose metabolism in cancer: lessons from a PKM knock-in model2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Loss of protein phosphatase 6 in mouse keratinocytes enhances K-rasG12D-driven tumor promotion.2018

Author(s)

Journal Title

Data Source

[Journal Article] Loss of protein phosphatase 6 in mouse keratinocytes enhances K-ras G12D -driven tumor promotion2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Ex vivo model of non-small cell lung cancer using mouse lung epithelial cells.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CDC25A mRNA levels significantly correlate with Ki-67 expression in human glioma samples.2010

Author(s)

Journal Title

Data Source

[Journal Article] MKP-7, a JNK phosphatase, blocks ERK-dependent gene activation by anchoring phosphorylated ERK in the cytoplasm.2010

Author(s)

Journal Title

Data Source

Nomura Miyuki 野村美有樹

野村美有樹ノムラミユキ

NOMURA Miyuki 野村美有樹