Obara Yutaro 小原祐太郎

… Alternative Names

OBARA YUTARO 小原祐太郎

OBARA Yutaro 小原祐太郎

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Researcher Number	40400270
Other IDs
Affiliation (Current)	2025: 山形大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2025: 山形大学, 医学部, 教授 2021 – 2023: 山形大学, 医学部, 教授 2012 – 2020: 山形大学, 医学部, 准教授 2007 – 2009: Tohoku University, 大学院・薬学研究科, 助教 2006: 東北大学, 大学院・薬学研究科, 助手 2006: 東北大学, 大学院薬学研究科, 助手
Review Section/Research Field	Principal Investigator Biological pharmacy / Basic Section 47040:Pharmacology-related / Basic Section 48030:Pharmacology-related / Pharmacology in pharmacy Except Principal Investigator Biological Sciences / Basic Section 47040:Pharmacology-related / Pharmacology in pharmacy
Keywords	Principal Investigator Midnolin (MIDN) / パーキンソン病 / ERK5 / 神経栄養因子 / midnolin / MAPK / NGF / チロシンヒドロキシラーゼ / PC12細胞 / 痴呆 … More / Parkinson's disease (PD) / ミドノリン（MIDN） / リスク遺伝子 / Midnolin (MIDN） / Midnolin（MIDN） / MIDN / 副腎髄質 / 神経細胞 / 褐色細胞腫 / ankrd1 / カテコラミン / シグナル伝逹 / 薬理学 / 脳・神経 / 神経科学 / シグナル伝達 / 1321N1細胞 / 神経突起伸展 / 神経成長因子(NGF) / グリア細胞 … More Except Principal Investigator 脂質ラフト / インターナリゼーション / 受容体刺激 / Kチャネル / 嗅球摘出 / スカブロニン / 海馬歯状回 / 嗅球摘出動物 / 記憶障害 / うつ / 動物モデル / 脳由来神経栄養因子 / うつ病 / 認知症 / 神経新生 / 薬理学 / 糖領 / 生体分子 / シグナル伝達 / 細胞・組織 / メチル-β-シクロデキストリン / 細胞遊走 / Rho / 11> / G_<q / シグナル伝逹 / アデニル酸シクラーゼ / ガングリオシド / コレステロール / Gβ / サイクリックAMP / G_s / Gタンパク質 Less

パーキンソン病のリスク遺伝子Midnolinの分子機能と生理的な役割の解明Principal Investigator
- Principal Investigator
  
  小原祐太郎
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48030:Pharmacology-related
- Research Institution
  Yamagata University
パーキンソン病の新しいリスク遺伝子Midnolin（MIDN）の分子基盤の構築Principal Investigator
- Principal Investigator
  
  小原祐太郎
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47040:Pharmacology-related
- Research Institution
  Yamagata University
Pathophysiological significance of decreased K channel expression by receptor activation
- Principal Investigator
  
  石井邦明
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47040:Pharmacology-related
- Research Institution
  Yamagata University
Clarification of pathophysiological roles of MIDN, a novel genetic risk factor for Parkinson's diseasePrincipal Investigator
- Principal Investigator
  
  OBARA YUTARO
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47040:Pharmacology-related
- Research Institution
  Yamagata University
Pathophysiological roles of ERK5 in catecholamine biosynthesisPrincipal Investigator
- Principal Investigator
  
  OBARA Yutaro
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pharmacology in pharmacy
- Research Institution
  Yamagata University
Development of hippocampal neurogenesis-promoting drugs as a target for the treatment and prevention of psychiatric disorders
- Principal Investigator
  
  NAKAGAWASAI Osamu
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pharmacology in pharmacy
- Research Institution
  Tohoku Medical and Pharmaceutical University
Novel molecular mechanism of neuronal functions by ERK5Principal Investigator
- Principal Investigator
  
  OBARA YUTARO
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Yamagata University
三量体Gタンパク質αサブユニットの脂質ラフト局在と脂質修飾に関する研究
- Principal Investigator
  
  中畑則道
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
Clarification of novel physiological roles of ERK5 in neuronsPrincipal Investigator
- Principal Investigator
  
  OBARA Yutaro
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Tohoku University
三量体Gタンパク質の脂質ラフト局在と活性調節の分子メカニズムに関する研究
- Principal Investigator
  
  中畑則道
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
新しい作用機序を有する天然由来抗痴呆症薬の研究Principal Investigator
- Principal Investigator
  
  小原祐太郎
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Tohoku University

[Journal Article] Structural Variants of <i>Midnolin</i>, a Genetic Risk Factor for Parkinson’s Disease, in a Yamagata Cohort2023
- Author(s)
  Hidenori Sato, Kuniaki Ishii, Yutaro Obara
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 46 Issue: 3 Pages: 379-381
- DOI
  10.1248/bpb.b22-00776
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2023-03-01
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K06573
[Journal Article] Insulin enhances gene expression of Midnolin, a novel genetic risk factor for Parkinson's disease, via ERK, PI3-kinase and multiple transcription factors in SH-SY5Y cells.2022
- Author(s)
  Naoki Sagehashi, Yutaro Obara, Ohki Maruyama, Tadashi Nakagawa, Toru Hosoi, Kuniaki Ishii
- Journal Title
  
  J. Pharmacol. Exp. Ther.
  
  Volume: - Issue: 2 Pages: 68-78
- DOI
  10.1124/jpet.121.001076
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06681, KAKENHI-PROJECT-19K07837, KAKENHI-PROJECT-20K12157
[Journal Article] Reply to: MIDN locus structural variants and Parkinson's disease risk.2020
- Author(s)
  Yutaro Obara, Hidenori Sato, Takahiro Nakayama, Takeo Kato, Kuniaki Ishii
- Journal Title
  
  Ann. Clin. Transl. Neurol.
  
  Volume: - Issue: 4 Pages: 604-605
- DOI
  10.1002/acn3.51011
- Open Access
- Data Source
  KAKENHI-PROJECT-18K06681
[Journal Article] Midnolin is a confirmed genetic risk factor for Parkinson’s disease.2019
- Author(s)
  Yutaro Obara, Hidenori Sato, Takahiro Nakayama, Takeo Kato, Kuniaki Ishii
- Journal Title
  
  Ann. Clin. Transl. Neurol.
  
  Volume: 6(11) Issue: 11 Pages: 2205-2211
- DOI
  10.1002/acn3.50914
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06681
[Journal Article] ERK5 Phosphorylates Kv4.2 and Inhibits Inactivation of the A-Type Current in PC12 Cells.2018
- Author(s)
  Yurina Kashino, Yutaro Obara, Yosuke Okamoto, Takeo Saneyoshi, Yasunori Hayashi, Kuniaki Ishii.
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 19(7) Issue: 7 Pages: 2008-2008
- DOI
  10.3390/ijms19072008
- NAID
  120006559401
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K15554, KAKENHI-PROJECT-15K07963, KAKENHI-PLANNED-18H05434, KAKENHI-PROJECT-16H02455, KAKENHI-PROJECT-17K19631
[Journal Article] Transcriptome Analysis Reveals That Midnolin Regulates mRNA Expression Levels of Multiple Parkinson’s Disease Causative Genes2018
- Author(s)
  小原　祐太郎、石井　邦明
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 41 Issue: 1 Pages: 20-23
- DOI
  10.1248/bpb.b17-00663
- NAID
  130006301305
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K07963
[Journal Article] Midnolin is a novel regulator of parkin expression and is associated with Parkinson’s Disease.2017
- Author(s)
  小原　祐太郎、今井　亨、佐藤　秀則、武田　裕司、加藤　丈夫、石井　邦明
- Journal Title
  
  Sci. Rep.
  
  Volume: 7 Issue: 1 Pages: 5885-5885
- DOI
  10.1038/s41598-017-05456-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K07963
[Journal Article] ERK5 induces ankrd1 for catecholamine biosynthesis and homeostasis in adrenal medullary cells2016
- Author(s)
  小原　祐太郎、長澤　隆介、根本　亙、Michael J. Pellegrino、高橋　麻穂、Beth A. Habecker、Philip J.S. Stork、一柳　統、伊藤　裕美、冨田　善彦、石井　邦明、中畑　則道
- Journal Title
  
  Cellular Signalling
  
  Volume: 28 Issue: 3 Pages: 177-189
- DOI
  10.1016/j.cellsig.2015.12.016
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07963, KAKENHI-PROJECT-26670118
[Journal Article] Expression of extracellular signal-regulated kinase 5 and ankyrin repeat domain 1 in composite pheochromocytoma and ganglioneuroblastoma detected incidentally in the adult adrenal gland: a case report2016
- Author(s)
  末永　信太、一柳　統、伊藤　裕美、内藤　整、加藤　智幸、長岡　明、加藤　智也、山川　光徳、小原　祐太郎、土谷　順彦
- Journal Title
  
  Internal medicine
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K07963
[Journal Article] Phosphorylation of ERK5 on Thr732 is associated with ERK5 nuclear localization and ERK5-dependent transcription.2015
- Author(s)
  本多　拓人、小原　祐太郎、山内　新、 Anthony D. Couvillon、 Justin J. Mason、石井　邦明、中畑　則道
- Journal Title
  
  PLoS ONE
  
  Volume: 10 Issue: 2 Pages: e0117914-e0117914
- DOI
  10.1371/journal.pone.0117914
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24790063, KAKENHI-PROJECT-26670118
[Journal Article] Is PIP2 involved in the insulin effect?2014
- Author(s)
  石井　邦明、Minghua Wu、小原　祐太郎
- Journal Title
  
  Channels
  
  Volume: 8 Issue: 5 Pages: 391-392
- DOI
  10.4161/19336950.2014.948758
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790063, KAKENHI-PROJECT-26670118
[Journal Article] Rap1 regulates actin cytoskeleton at endothelial cell-cell junctions by spatially controlling myosin II activlty2013
- Author(s)
  Ando K, S. Fukuhara, Y. Obars, T. Noriya. N. Nakahata, N. Moohizuki.
- Journal Title
  
  Journal of Cell Biology
  
  Volume: 202 Issue: 6 Pages: 901-916
- DOI
  10.1083/jcb.201301115
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J04798, KAKENHI-PLANNED-22113009, KAKENHI-PROJECT-24370084, KAKENHI-PROJECT-24790063, KAKENHI-PROJECT-25293050
[Journal Article] ようやく見えて来た神経系におけるERK5の機能2013
- Author(s)
  小原　祐太郎
- Journal Title
  
  日本薬理学雑誌
  
  Volume: 141
- NAID
  10031171126
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790063
[Journal Article] G_<αh>/transglutaminase-2 activity is required for maximal activatio of adenylylcyclase 8 in human and rat g(n) lioma cells2013
- Author(s)
  Obara Y, Yanagihata Y, Abe T, Dafik L, Ishii K, Nakahata N.
- Journal Title
  
  Cell Signal
  
  Volume: 25 Issue: 3 Pages: 589-597
- DOI
  10.1016/j.cellsig.2012.11.021
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590235, KAKENHI-PROJECT-24790063
[Journal Article] Insulin suppresses IKs (KCNQ1/KCNE1) currents, which require β-subunit KCNE1.2013
- Author(s)
  呉　明華、小原　祐太郎、野呂田　郁夫、永澤　悦伸、石井　邦明
- Journal Title
  
  Pflugers Archiv - Eur J Physiol
  
  Volume: - Issue: 5 Pages: 937-946
- DOI
  10.1007/s00424-013-1352-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790063, KAKENHI-PROJECT-26670118
[Journal Article] Neurite Outgrowth of PC12 Cells by 4'-O-β-D-glucopyranosyl-3',4- dimethoxychalcone from Brassica rapa L. 'hidabeni' was enhanced by pretreatment with p38MAPK inhibitor.2013
- Author(s)
  仁科　淳良、Hirokazu Kimura, Hiroyuki Tsukagoshi, Kunihisa Kozawa, Mamoru Koketsu, Masayuki Ninomiya, Daisuke Sato、小原　祐太郎、古川　昭栄
- Journal Title
  
  Neurochem Res
  
  Volume: 38 Issue: 11 Pages: 2397-2407
- DOI
  10.1007/s11064-013-1152-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790063
[Journal Article] 神経系におけるERK5の役割について2013
- Author(s)
  小原　祐太郎、石井　邦明
- Journal Title
  
  日本薬理学雑誌
  
  Volume: 141
- NAID
  10031177895
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790063
[Journal Article] 多彩な機能を有するGh/トランスグルタミナーゼ22013
- Author(s)
  小原　祐太郎、石井　邦明
- Journal Title
  
  日本薬理学雑誌
  
  Volume: 141 Pages: 225-225
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790063
[Journal Article] Endocytic regulation of voltage-dependent potassium channels in heart.2012
- Author(s)
  石井　邦明、野呂田　郁夫、小原　祐太郎
- Journal Title
  
  J. Pharmacol. Sci.
  
  Volume: 120 Pages: 264-269
- NAID
  10031147574
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790063
[Journal Article] Involvement of lipid rafts in multiple signal transductions mediated by two isoforms of thromboxane A<sub>2</sub> receptor: Dependency on receptor isoforms and downstream signaling types2012
- Author(s)
  Shinji Goto, Masaki Saito, Yutaro Obara, Takahiro Moriya, Norimichi Nakahata
- Journal Title
  
  European Journal of Pharmacology
  
  Volume: 693 Issue: 1-3 Pages: 15
- DOI
  10.1016/j.ejphar.2012.07.046
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23770136, KAKENHI-PROJECT-24790063
[Journal Article] The signaling pathway leading to ERK5 activation via G-proteins and ERK5-dependent neurotrophic effects.2010
- Author(s)
  Yutaro Obara*, Norimichi Nakahata.
- Journal Title
  
  Mol Pharmacol 77
  
  Pages: 10-16
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790053
[Journal Article] The signaling pathway leading to ERK5 activation via G-proteins and ERK5-dependent neurotrophic effects2010
- Author(s)
  Yutaro Obara, Norimichi Nakahata
- Journal Title
  
  Mol Pharmacol 77
  
  Pages: 10-16
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790053
[Journal Article] Thromboxane A_2 receptor-mediated epidermal growth factor receptor(EGFR)transactivation : involvement of PKC-d and PKC-e in shedding of EGFR ligands2009
- Author(s)
  Kotomi Uchiyama, Masaki Saito, Masako Sasaki, Yutaro Obara, Shigeki Higashiyama, Norimichi Nakahata
- Journal Title
  
  Eur.J.Pharm.Sci. 38
  
  Pages: 504-511
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20054002
[Journal Article] ERK5 acitivity is required for NGF-induced neurite outgrowth and stabilization of tyrosine hydroxylase in PC12 cells2009
- Author(s)
  Yutaro Obara, Arata Yamauchi, Shin Takehara, Wataru Nemoto, Maho Takahashi, Philip J.S.Stork, Norimichi Nakahata
- Journal Title
  
  J.Biol.Chem. 284
  
  Pages: 23564-23573
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20054002
[Journal Article] ERK5 activity is required for NGF-induced neurite outgrowth and stabilization of tyrosine hydroxylase in PC12 cells2009
- Author(s)
  Yutaro Obara, Arata Yamauchi, Shin Takehara, Wataru Nemoto, Maho Takahashi, Philip J.S.Stork, Norimichi Nakahata
- Journal Title
  
  J Biol Chem 284
  
  Pages: 23564-23573
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790053
[Journal Article] ERK5 activity is required for NGF-induced neurite outgrowth and stabilization of tyrosine hydroxylase in PC12 cells.2009
- Author(s)
  Yutaro Obara*, Arata Yamauchi, Shin Takehara, Wataru Nemoto, Maho Takahashi, Philip J.S. Stork, Norimichi Nakahata.
- Journal Title
  
  J Biol Chem 284
  
  Pages: 23564-23573
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790053
[Journal Article] 神経系細胞におけるcAMPによるERK1/活性化のシグナル伝達について(総説)2009
- Author(s)
  Yutaro Obara, Norimichi Nakahata, Philip J.S. Stork
- Journal Title
  
  日本薬理学雑誌 133
  
  Pages: 63-68
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790053
[Journal Article] Thromboxane A_2 receptor-mediated epidermal growth factor receptor transactivation : Involvement of PKC-delta and PKC-epsilon in the shedding of epidermal growth factor receptor ligands2009
- Author(s)
  Kotomi Uchiyama, Masaki Saito, Masako Sasaki, Yutaro Obara, Shigeki Higashiyama, Norimichi Nakahata
- Journal Title
  
  Eur J Pharm Sci 38
  
  Pages: 504-511
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790053
[Journal Article] Thromboxane A2 receptor-mediated epidermal growth factor receptor transactivation: Involvement of PKC-delta and PKC-epsilon in the shedding of epidermal growth factor receptor ligands.2009
- Author(s)
  Kotomi Uchiyama, Masaki Saito, Masako Sasaki, Yutaro Obara, Shigeki Higashiyama, Norimichi Nakahata.
- Journal Title
  
  Eur J Pharm Sci 38
  
  Pages: 504-511
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790053
[Journal Article] ERK activation by cAMP signaling in neuronal cells2009
- Author(s)
  Yutaro Obara*, Norimichi Nakahata, Philip J.S. Stork.
- Journal Title
  
  Nippon Yakurigaku Zasshi 133(Review)
  
  Pages: 63-68
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790053
[Journal Article] βγsubunits of Gi/o suppress EGF-induced ERK5 phosphorylation, whereas ERK1/2 phosphorylation is enhanced.2008
- Author(s)
  Yutaro Obara*, Yumiko Okano, Sachiko Ono, Arata Yamauchi, Tomohiro Hoshino, Hitoshi Kurose, Norimichi Nakahata.
- Journal Title
  
  Cell Signal 20
  
  Pages: 1275-1283
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790053
[Journal Article] fly subunits of Gi/o suppress EGF-induced ERK5 phosphorylation, whereas ERK1/2 phosphorylation is enhanced2008
- Author(s)
  Yutaro Obara, Yumiko Okano, Sachiko Ono, Arata Yamauchi, Tomohiro Hoshino, Hitoshi Kurose and Norimichi Nakahata
- Journal Title
  
  Cell. Signal 20
  
  Pages: 1275-1283
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20054002
[Journal Article] βγ subunits of G_<i/o> suppress EGF-induced ERK5 phosphorylation, whereas ERK1/2 phosphorylation is enhanced2008
- Author(s)
  Yutaro Obara, Yumiko Okano, Sachiko Ono, Arata Yamauchi, Tomohiro Hoshino, Hitoshi Kurose, Norimichi Nakahata
- Journal Title
  
  Cell Signal 20
  
  Pages: 1275-1283
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790053
[Journal Article] 神経系細胞におけるcAMPによるERK1/2活性化のシグナル伝達について2008
- Author(s)
  小原祐太郎、中畑則道、Phihp J. S. Stork
- Journal Title
  
  日薬理誌 113
  
  Pages: 63-68
- NAID
  10025739906
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20054002
[Journal Article] NGF-inducing activity of Hericium erinaceum in 1321N1 human astrocytoma cells.2008
- Author(s)
  Koichiro Mori, Yutaro Obara, Mitsuru Hirota, Yoshihito, Adumi, Satomi Kinugasa, Satoshi Inatomi, Norimichi Nakahata.
- Journal Title
  
  Biol Pharm Bull 31
  
  Pages: 1727-1732
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790053
[Journal Article] NGF-inducing activity of Hericium erinaceum in 1321N1 human astrocytoma cells2008
- Author(s)
  Koichiro Mori, Yutaro Obara, Mitsuru Hirota, Yoshihito, Adumi, Satomi Kinugasa, Satoshi Inatomi, and Norimichi Nakahata
- Journal Title
  
  Biol Pharm Bull 31
  
  Pages: 1727-1732
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790053
[Journal Article] A novel cyathane diterpene, cyrneine A, induces neurite outgrowth in a Rac1-dependent mechanism in PC12 cells.2007
- Author(s)
  Yutaro Obara, Tomohiro Hoshino, Maria Carla Marcotullio, Rita Pagiotti, Norimichi Nakahata.
- Journal Title
  
  Life Sci 80
  
  Pages: 1669-1677
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18790039
[Journal Article] A novel cyathane diterpene, cyrneine A, induces neurite outgrowth in a Racl-dependent mechanism in PC12 cells2007
- Author(s)
  Yutaro Obara, Tomohiro Hoshino, Maria Carla Marcotullio, Rita Pagiotti, Norimichi Nakahata
- Journal Title
  
  Life Sci. 80
  
  Pages: 1669-1677
- Data Source
  KAKENHI-PROJECT-18057002
[Journal Article] Cyathane diterpenes from Sarcodon cyrneus and evaluation of their activities of neuritegenesis and nerve growth factor production.2007
- Author(s)
  Maria Carla Marcotullio, Rita Pagiotti, Federica Maltese, Gildas Norbert Oball-Mond Mwankie, Tomohiro Hoshino, Yutaro Obara, Norimichi Nakahata.
- Journal Title
  
  Bioorg Med Chem 15
  
  Pages: 2878-2882
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18790039
[Journal Article] Complanadines C and D, new dimeric alkaloids from Lycopodium complanatum2007
- Author(s)
  Kan'ichiro Ishiuchl, Takaaki Kubota, Yuzuru Mikami, Yutaro Obara, Norimichi Nakahata, Jun'ichi Kobayashi
- Journal Title
  
  Bioorg. Med. Chem. 15
  
  Pages: 413-417
- Data Source
  KAKENHI-PROJECT-18057002
[Journal Article] Cyathane diterpenes from Sarcodon cyrneus and evaluation of their neuritogenesis and nerve growth factor production2007
- Author(s)
  Maria Carla Marcotullio, Rita Pagiotti, Federica Maltese, Gildas Norbert Oball-Mond Mwankie, Tomohiro Hoshino, Yutaro Obara, Norimichi Nakahata
- Journal Title
  
  Bioorg. Med. Chem. 15
  
  Pages: 2878-2882
- Data Source
  KAKENHI-PROJECT-18057002
[Journal Article] Lycopladine E, a new C16N1-type alkaloid from Lycopodium complanatum.2007
- Author(s)
  Takaaki Kubota, Hiroko Yahata, Kan'ichiro Ishiuchi, Yutaro Obara, Norimichi Nakahata, Junichi Kobayashi.
- Journal Title
  
  Heterocycles 74
  
  Pages: 843-848
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18790039
[Journal Article] Complanadines C and D, new dimeric alkaloids from Lycopodium complanatum.2007
- Author(s)
  Kan'ichiro Ishiuchi, Takaaki Kubota, Yuzuru Mikami, Yutaro Obara, Norimichi Nakahata, Jun'ichi Konayashi
- Journal Title
  
  Bioorg. Med. Chem. 15
  
  Pages: 413-417
- Data Source
  KAKENHI-PROJECT-18790039
[Journal Article] 5, 19-cyclo-9β, 10ξ-androstane-3, 17 dione promotes neurotrophic factor biosynthesis in 1321N1 human astrocytoma cells and improves passive avoidance learning impairment.2007
- Author(s)
  Yutaro Obara, Asami Haganuma, Shinsuke Murakami, Toshiki Chiba, Koichiro Mori, Osamu Nakagawasai, Takeshi Tadano, Haruhisa Kikuchi, Yoshiteru Oshima, Norimichi Nakahata.
- Journal Title
  
  Brain Res 1184
  
  Pages: 57-64
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18790039
[Journal Article] The requirement of Ras and Rap1 for the activation of ERKs by cAMP, PACAP, and KCl in cerebellar granule cells.2007
- Author(s)
  Yutaro Obara, Angela Horgan, Philip Stork.
- Journal Title
  
  J Neurochem 101
  
  Pages: 470-482
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18790039
[Journal Article] Lycopladines B-D and lyconadin B, new alkaloids from Lycopodium complanatum2006
- Author(s)
  Kan'ichiro Ishiuchi, Takaaki Kubota, Tomohiro Hoshino, Yutaro Obara, Norimichi Nakahata, Jun'ichi Kobayashi
- Journal Title
  
  Bioorg. Med. Chem. 14
  
  Pages: 5995-6000
- Data Source
  KAKENHI-PROJECT-18057002
[Journal Article] Lycopladines B-D and lyconadin B, new alkaloids from Lycopodium complanatum.2006
- Author(s)
  Kan'ichiro Ishiuchi, Takaaki Kubota, Tomohiro Hoshino, Yutaro Obara, Norimichi Nakahata, Jun'ichi Konayashi
- Journal Title
  
  Bioorg. Med. Chem. 14
  
  Pages: 5995-6000
- Data Source
  KAKENHI-PROJECT-18790039
[Journal Article] Neurotrophic factor production in human astrocytoma cells by 2,5,6-tribromogramine via activation of epsilon isoform of protein kinase C.2006
- Author(s)
  Masaki Saito, Megumi Hori, Yutaro Obara, Yasushi Ohizumi, Satoko Ohkubo, Norimichi Nakahata
- Journal Title
  
  Eur. J. Pharm. Sci. 28
  
  Pages: 263-271
- Data Source
  KAKENHI-PROJECT-18790039
[Journal Article] Neurite outgrowth activity of cyathane diterpenes from Sarcodon cyrneus, Cyrneines A and B.2006
- Author(s)
  Maria Carla Marcotullio, Rita Pagiotti, Federica Maltese, Yutaro Obara, Tomohiro Hoshino, Norimichi Nakahata, Massimo Curini
- Journal Title
  
  Planta Med. 72
  
  Pages: 819-823
- Data Source
  KAKENHI-PROJECT-18790039
[Journal Article] Neurotrophic factor secretion from human astrocytoma cells by 2,5,6-tribromogramine via activation of epsilon isoform of protein kinase C2006
- Author(s)
  Masaki Saito, Megumi Hori, Yutaro Obara, Yasushi Ohizumi, Satoko Ohkubo, Norimichi Nakahata
- Journal Title
  
  Eur. J. Pharm. Pharmacol. 28
  
  Pages: 263-271
- Data Source
  KAKENHI-PROJECT-18057002
[Journal Article] Development of anti-dementia drugs related to neurotrophic factors.2006
- Author(s)
  Yutaro Obara.
- Journal Title
  
  Yakugaku Zasshi 126
  
  Pages: 747-755
- NAID
  110006154985
- Data Source
  KAKENHI-PROJECT-18790039
[Journal Article] Inhibitory effect of naringin on lipopolysaccharide (LPS)-induced endotoxin shock in mice and nitric oxide production in RAW 264.7 macrophages2006
- Author(s)
  Syu-ichi Kanno, Ai Shouji, Ayako Tomizawa, Takako Hiura, Yuu Osanai, Mayuko Ujibe, Yutaro Obara, Norimichi Nakahata, Masaaki Ishikawa
- Journal Title
  
  Life Sci. 78
  
  Pages: 673-681
- Data Source
  KAKENHI-PROJECT-18057002
[Journal Article] Inhibitory effect of naringin on lipopolysaccharide (LPS)-induced endotoxin shock in mice and nitric oxide production in RAW 264.7 macrophages.2006
- Author(s)
  Syu-ichi Kanno, Ai Shouji, Ayako Tomizawa, Takako Hiura, Yuu Osanai, Mayuko Ujibe, Yutaro Obara, Norimichi Nakahata, Masaaki Ishikawa
- Journal Title
  
  Life Sci. 78
  
  Pages: 673-681
- Data Source
  KAKENHI-PROJECT-18790039
[Journal Article] Neurite outgrowth activity of cyathane diterpenes from Sarcodon cyrneus, Cyrneines A and B2006
- Author(s)
  Maria Carla Marcotullio, Rita Pagiotti, Federica Maltese, Yutaro Obara, Tomohiro Hoshino, Norimichi Nakahata, Massimo Curini
- Journal Title
  
  Planta Medica 72
  
  Pages: 819-823
- Data Source
  KAKENHI-PROJECT-18057002
[Presentation] A novel genetic risk factor, Midnolin, promotes neurite outgrowth in PC12 cells.2023
- Author(s)
  加藤　千聖、千葉　彩乃、野呂田　郁夫、永嶋　未華子、石井　邦明、小原　祐太郎
- Organizer
  第97回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-21K06573
[Presentation] Midnolin regulates the transcriptional activity of early growth response 1.2023
- Author(s)
  千葉　彩乃、加藤　千聖、尾崎　司、野呂田　郁夫、永嶋　未華子、石井　邦明、小原　祐太郎
- Organizer
  第97回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-21K06573
[Presentation] EGR1を介したMidnolinの機能解明によるパーキンソン病治療ターゲットの探索2023
- Author(s)
  千葉　彩乃、加藤　千聖、尾崎　司、野呂田　郁夫、永嶋　美華子、石井　邦明、小原　祐太郎
- Organizer
  第74回日本薬理学会北部会
- Data Source
  KAKENHI-PROJECT-21K06573
[Presentation] パーキンソン病のリスク遺伝子Midnolinの病態生理学的な役割2023
- Author(s)
  小原　祐太郎
- Organizer
  第62回日本薬学会東北支部会
- Invited
- Data Source
  KAKENHI-PROJECT-21K06573
[Presentation] Midnolinの発現を増強するパーキンソン病の治療薬の探索2023
- Author(s)
  野呂田　郁夫、瑞木　優祐、千葉　彩乃、永嶋　美華子、小倉　次郎、山口　浩明、石井　邦明、小原　祐太郎
- Organizer
  第74回日本薬理学会北部会
- Data Source
  KAKENHI-PROJECT-21K06573
[Presentation] インスリンはAP-1を介して、パーキンソン病の新規リスク遺伝子であるMIDNの発現を促進する2022
- Author(s)
  ○小原祐太郎，提箸尚貴，丸山央記，石井邦明
- Organizer
  第95回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-18K06681
[Presentation] 日本と英国において、MIDN遺伝子はパーキンソン病の強いリスク遺伝子である。2020
- Author(s)
  小原祐太郎、佐藤秀則、中山貴博、加藤丈夫、石井邦明
- Organizer
  第93回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-18K06681
[Presentation] PC12細胞において、ERK5によるKv4.2のリン酸化によって、A電流の不活性化が抑制される。2020
- Author(s)
  樫野友利奈、小原祐太郎、岡本洋介、実吉岳郎、林康紀、石井邦明
- Organizer
  第93回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-18K06681
[Presentation] パーキンソン病の新規リスク遺伝子Midnolinの発現調節機構の解明2020
- Author(s)
  提箸尚貴、小原祐太郎、丸山央記、石井邦明
- Organizer
  第71回　日本薬理学会北部会
- Data Source
  KAKENHI-PROJECT-18K06681
[Presentation] MIDN遺伝子座の構造変化とパーキンソン病の発症リスクについて2020
- Author(s)
  小原祐太郎、佐藤秀則、中山貴博、加藤丈夫、石井邦明
- Organizer
  第71回　日本薬理学会北部会
- Data Source
  KAKENHI-PROJECT-18K06681
[Presentation] Midnolinは神経突起伸展とparkinユビキチンリガーゼの発現を促進し、パーキンソン病と関連する。2019
- Author(s)
  小原祐太郎、今井亨、提箸尚貴、佐藤秀則、武田裕司、加藤丈夫、石井邦明
- Organizer
  第92回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-15K07963
[Presentation] Midnolinとパーキンソン病の関連性2019
- Author(s)
  提箸尚貴、小原祐太郎、石井邦明
- Organizer
  第70回日本薬理学会北部会
- Data Source
  KAKENHI-PROJECT-18K06681
[Presentation] Midnolinは神経突起伸展とparkinユビキチンリガーゼの発現を促進し、パーキンソン病と関連する。2019
- Author(s)
  小原祐太郎、今井亨、提箸尚貴、佐藤秀則、武田裕司、加藤丈夫、石井邦明
- Organizer
  第92回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-18K06681
[Presentation] パーキンソン病に関する最新の話題2018
- Author(s)
  小原祐太郎
- Organizer
  日本早期認知症学会春季ワークショップ2018
- Invited
- Data Source
  KAKENHI-PROJECT-18K06681
[Presentation] パーキンソン病に関する最新の話題2018
- Author(s)
  小原　祐太郎
- Organizer
  日本早期認知症学会春季ワークショップ2018
- Invited
- Data Source
  KAKENHI-PROJECT-15K07963
[Presentation] Midnolin is a novel risk factor for Parkinson's Disease and regulates expression of parkin and other causative genes.2018
- Author(s)
  小原祐太郎、今井亨、佐藤秀則、武田裕司、加藤丈夫、石井邦明
- Organizer
  第18回 World Congress of Basic and Clinical Pharmacology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06681
[Presentation] Midnolin is a novel risk factor for Parkinson's Disease and regulates expression of parkin and other causative genes.2018
- Author(s)
  小原祐太郎、今井亨、佐藤秀則、武田裕司、加藤丈夫、石井邦明
- Organizer
  第18回 World Congress of Basic and Clinical Pharmacology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07963
[Presentation] 各種イオンチャネルの発現におけるERK5の役割の解明2017
- Author(s)
  樫野　友利奈、小原　祐太郎、石井　邦明
- Organizer
  第90回日本薬理学会年会
- Place of Presentation
  長崎ブリックホール（長崎県・長崎市）
- Year and Date
  2017-03-15
- Data Source
  KAKENHI-PROJECT-15K07963
[Presentation] ERK5 は腎細胞癌に対する薬物治療の新規ターゲットになりうる2017
- Author(s)
  菅野秀典、内藤整、伊藤裕美、一柳統、小原祐太郎、成澤貴史、加藤智幸、長岡明、石井邦明、土谷順彦
- Organizer
  第68回　日本薬理学会北部会
- Data Source
  KAKENHI-PROJECT-15K07963
[Presentation] Midnolin とパーキンソン病の関連性の解明2017
- Author(s)
  第68回　小原祐太郎、今井亨、佐藤秀則、武田裕司、加藤丈夫、石井邦明
- Organizer
  第68回　日本薬理学会北部会
- Data Source
  KAKENHI-PROJECT-15K07963
[Presentation] スカブロニンG-メチルエステルの認知障害改善作用とその機序について2016
- Author(s)
  小平貴代，中川西修，林嘉蓉，根本亙，佐久間若菜，小原祐太郎，小早川優，中田雅久，丹野孝一
- Organizer
  次世代を担う創薬・医療薬理シンポジウム2016
- Place of Presentation
  東北大学川内キャンパス（宮城県仙台市）
- Data Source
  KAKENHI-PROJECT-26460102
[Presentation] 神経細胞におけるMidnolinの生理的・病理的な役割について2015
- Author(s)
  今井亨、小原　祐太郎、佐藤　秀則、加藤　丈夫、石井　邦明
- Organizer
  第66回日本薬理学会北部会
- Place of Presentation
  富山国際会議場（富山県・富山市）
- Year and Date
  2015-09-18
- Data Source
  KAKENHI-PROJECT-15K07963
[Presentation] Scabronine G-methylester attenuates hippocampal neurogenesis impairment and the memory deficits induced by olfactory bulbectomy2015
- Author(s)
  Jia Rong Lin, Osamu Nakagawasai, Wataru Nemoto, Yutaro Obara, Fukie Yaoita, Yu Kobayakawa, Masahisa Nakada, Koichi Tan-No
- Organizer
  第24回神経行動薬理若手研究者の集い
- Place of Presentation
  名古屋、愛知県
- Year and Date
  2015-03-17
- Data Source
  KAKENHI-PROJECT-26460102
[Presentation] ヒトおよびラットグリオーマ細胞において、Gαh/TG2はアデニル酸シクラーゼ8の活性を増大させる2014
- Author(s)
  小原　祐太郎、柳畑　佳美、阿部　友大、 Laila Dafik、石井　邦明、中畑　則道
- Organizer
  第86回日本薬理学会年会
- Place of Presentation
  仙台国際会議場（仙台）
- Data Source
  KAKENHI-PROJECT-24790063
[Presentation] NGFはRasとRap1非依存的にERK5を活性化し、神経突起の伸展とカテコラミンの生合成を促進する2014
- Author(s)
  小原　祐太郎、Philip Stork、Beth Habecker、石井　邦明、中畑　則道
- Organizer
  第86回日本薬理学会年会
- Place of Presentation
  仙台国際会議場（仙台）
- Data Source
  KAKENHI-PROJECT-24790063
[Presentation] 神経栄養因子の作用メカニズムとその生合成機構に関する薬理学的研究2013
- Author(s)
  小原　祐太郎
- Organizer
  第86回日本薬理学会年会
- Place of Presentation
  福岡国際会議場（福岡）
- Invited
- Data Source
  KAKENHI-PROJECT-24790063
[Presentation] Gαh/TG2 promotes cAMP production accompanied by a modification of adenylylcyclase 8 in human and rat glioma cells.2013
- Author(s)
  小原　祐太郎、柳畑　佳美、阿部　友大、 Laila Dafik、石井　邦明、中畑　則道
- Organizer
  ニューロサイエンス学会2013
- Place of Presentation
  サンディエゴコンベンションセンター（サンディエゴ、アメリカ）
- Data Source
  KAKENHI-PROJECT-24790063
[Presentation] ERK5とERK1/2のクロストーク機構の解析2012
- Author(s)
  小原　祐太郎、本多　拓人、山内　新、石井　邦明、中畑　則道
- Organizer
  第63回日本薬理学会北部会
- Place of Presentation
  朱鷺メッセ（新潟）
- Data Source
  KAKENHI-PROJECT-24790063
[Presentation] Gα_h/トランスグルタミナーゼ2を介する細胞内Ca^<2+>濃度、及びアデニル酸シクラーゼ活性制御の解析2010
- Author(s)
  柳畑佳未、阿部友大、小原祐太郎、中畑則道
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-20054002
[Presentation] PC12細胞の分化におけるERK5の生理的意義について2010
- Author(s)
  小原祐太郎、山内新、根本亙、竹原伸、高橋麻穂、Philip Stork、中畑則道
- Organizer
  第1回Gタンパク質班会議若手研究会
- Place of Presentation
  東京
- Year and Date
  2010-02-07
- Data Source
  KAKENHI-PROJECT-20790053
[Presentation] PC12細胞の分化におけるERK5の役割について2010
- Author(s)
  小原祐太郎、山内新、竹原伸、根本亙、高橋麻穂、Philip Stork、中畑則道
- Organizer
  日本薬理学会年会
- Place of Presentation
  大阪
- Year and Date
  2010-03-18
- Data Source
  KAKENHI-PROJECT-20790053
[Presentation] ラットC6グリオーマ細胞においてERK5は神経栄養因子・サイトカイン類の遺伝子発現に関与する2010
- Author(s)
  根本亙、小原祐太郎、村田富保、金田典雄、中畑則道
- Organizer
  第83回日本薬理学会年会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-20054002
[Presentation] PC12細胞の分化におけるERK5の役割について2010
- Author(s)
  小原祐太郎、山内新、竹原伸、根本亙、高橋麻穂、Philip J.S.Stork、中畑則道
- Organizer
  第83回日本薬理学会年会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-20054002
[Presentation] ERK5 mediates neurite outgrowth and stabilization of tyrosine hydroxylase protein by NGF in PC12 cells.2009
- Author(s)
  小原祐太郎、山内新、竹原c高橋麻穂、Philip Stork、中畑則道
- Organizer
  第2回International Symposium on Cellular Signaling
- Place of Presentation
  つくば
- Year and Date
  2009-11-19
- Data Source
  KAKENHI-PROJECT-20790053
[Presentation] NGFによるPC12細胞の神経突起伸展とチロシンヒドロキシラーゼタンパク質の安定化にERK5が関与する2009
- Author(s)
  山内新、小原祐太郎、竹原伸、根本亙、高橋麻穂、Philip Stork、中畑則道
- Organizer
  第6回東北大学バイオサイエンスシンポジウム
- Place of Presentation
  仙台
- Year and Date
  2009-06-16
- Data Source
  KAKENHI-PROJECT-20790053
[Presentation] ERK5 is required for NGF-induced neurite outgrowth and stabilization of tyrosine hydroxylase protein in PC12 cells2009
- Author(s)
  小原祐太郎、山内新、竹原伸、根本亙、高橋麻穂、Philip J.S.Stork、中畑則道
- Organizer
  Society for Neuroscience 39th Meeting
- Place of Presentation
  Chicago, IL, U.S.A.
- Data Source
  KAKENHI-PROJECT-20054002
[Presentation] NGFによるPC12細胞の神経突起伸展作用とチロシンヒドロキシラーゼタンパク質の安定化にERK5が関与する2009
- Author(s)
  山内新、小原祐太郎、竹原伸、根本亙、高橋麻穂、Philip Stork、中畑則道
- Organizer
  第6回東北大学バイオサイエンスシンポジウム
- Place of Presentation
  仙台
- Year and Date
  2009-06-16
- Data Source
  KAKENHI-PROJECT-20790053
[Presentation] ラットC6グリオーマ細胞における神経栄養因子・サイトカイン類の遺伝子発現に関するERK5の役割について2009
- Author(s)
  根本亙、小原祐太郎、村田富保、金田典雄、中畑則道
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸
- Year and Date
  2009-10-24
- Data Source
  KAKENHI-PROJECT-20054002
[Presentation] ERK5 is required for NGF-induced neurite outgrowth and stabilization of tyrosine hydroxylase protein in PC12 cells2009
- Author(s)
  小原祐太郎、山内新、竹原伸、根本亙、高橋麻穂、Philip Stork、中畑則道
- Organizer
  第39回神経科学学会
- Place of Presentation
  シカゴ, アメリカ
- Year and Date
  2009-10-21
- Data Source
  KAKENHI-PROJECT-20790053
[Presentation] ERK5 mediates neurite outgrowth and stabilization of tyrosine hydroxylase protein by NGF in PC12 cells2009
- Author(s)
  小原祐太郎、山内新、竹原伸、根本亙、高橋麻穂、Philip J.S.Stork、中畑則道
- Organizer
  International Symposium on Cellular Signaling
- Place of Presentation
  Tukuba, Ibaragi
- Data Source
  KAKENHI-PROJECT-20054002
[Presentation] ERK5はPC12細胞の神経突起進展とチロシンヒドロキシラーゼの発現を制御する2009
- Author(s)
  山内新、○小原祐太郎、竹原伸、 Philip Stork、中畑則道
- Organizer
  日本薬理学会年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-20790053
[Presentation] トロンボキサンA2受容体シグナル伝達における非典型的Ghタンパク質の役割について2009
- Author(s)
  阿部友大、柳畑佳美、小原祐太郎、中畑則道
- Organizer
  科学研究費特定領域"Gタンパク質シグナル"&"膜輸送複合体"合同若手ワークショップ2009
- Place of Presentation
  神戸
- Year and Date
  2009-01-29
- Data Source
  KAKENHI-PROJECT-20790053
[Presentation] PKA/ホタルルシフェラーゼ融合タンパク質(GloSensor cAMP)を用いた新しいcAMPの定量法について2009
- Author(s)
  小原祐太郎、柳畑佳未、阿部友大、中畑則道
- Organizer
  科学研究費特定領域班会議
- Place of Presentation
  千葉
- Year and Date
  2009-09-10
- Data Source
  KAKENHI-PROJECT-20790053
[Presentation] ERK5はPC12細胞の神経突起伸展とチロシンヒドロキシラーゼの発現を制御する2009
- Author(s)
  山内新、小原祐太郎、Philip J.S. Stork、中畑則道
- Organizer
  日本薬理学会年会
- Place of Presentation
  横浜
- Year and Date
  2009-03-18
- Data Source
  KAKENHI-PROJECT-20790053
[Presentation] ERK5 is required for NGF-induced neurite outgrowth and stabilization of tyrosine hydroxylase protein in PC12 cells.2009
- Author(s)
  小原祐太郎、山内新、竹原伸、根本亙、高橋麻穂、Philip Stork、中畑則道
- Organizer
  第39回神経科学学会
- Place of Presentation
  シカゴ、アメリカ
- Year and Date
  2009-10-21
- Data Source
  KAKENHI-PROJECT-20790053
[Presentation] トロンボキサンA_2受容体のシグナル伝達における非典型的G_hタンパク質の役割について2009
- Author(s)
  阿部友大、柳畑佳美、○小原祐太郎、中畑則道
- Organizer
  科学研究費特定領域"Gタンパク質シグナル&膜輸送複合体"合同若手ワークショップ2009
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-20790053
[Presentation] 1321N1ヒトアストロサイトーマ細胞におけるトロンポキサンA2受容体シグナル伝達に関するG、タンパク質の役割について2009
- Author(s)
  阿部友大、小原祐太郎、柳畑佳未、中畑則道
- Organizer
  第82回日本薬理学会年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-20054002
[Presentation] ERK5はPC12細胞の神経突起伸展とチロシンヒドロキシラーゼタンパク質の安定化を媒介する2009
- Author(s)
  小原祐太郎、山内新、竹原伸、根本亙、高橋麻穂、Philip Stork、中畑則道
- Organizer
  第8回生命科学研究会
- Place of Presentation
  有馬
- Year and Date
  2009-06-27
- Data Source
  KAKENHI-PROJECT-20790053
[Presentation] ERK5はPC12細胞の神経突起伸展とチロシンヒドロキシラーゼの発現を抑制する2009
- Author(s)
  山内新、小原祐太郎、竹原伸、ストークフィリップ、中畑則道
- Organizer
  第82回日本薬理学会年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-20054002
[Presentation] NGFによるPC12細胞の神経突起伸展作用とチロシンヒドロキシラーゼタンパク質の安定化にERK5が関与する2009
- Author(s)
  山内新、小原祐太郎、竹原伸、根本亙、高橋麻穂、Philip Stork、中畑則道
- Organizer
  第6回東北大学バイオサイエンスシンポジウム
- Place of Presentation
  仙台
- Year and Date
  2009-06-16
- Data Source
  KAKENHI-PROJECT-20054002
[Presentation] ERK5 mediates neurite outgrowth and stabilization of tyrosine hydroxylase protein by NGF in PC12 cells2009
- Author(s)
  小原祐太郎、山内新、竹原伸、根本亙、高橋麻穂、Philip Stork、中畑則道
- Organizer
  第2回 International Symposium on Cellular Signaling
- Place of Presentation
  つくば
- Year and Date
  2009-11-19
- Data Source
  KAKENHI-PROJECT-20790053
[Presentation] P2Y2受容体とαvβ3/β5インテグリンとの相互作用に対する脂質ラフトの関与2009
- Author(s)
  安藤康史、須釜淳、小原祐太郎、中畑則道
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸
- Year and Date
  2009-10-24
- Data Source
  KAKENHI-PROJECT-20054002
[Presentation] PKA/ホタルルシフェラーゼ融合タンパク質(GloSensor cAMP^<TM>)を用いた新しいcAMPの定量法について2009
- Author(s)
  小原祐太郎、柳畑佳未、阿部友大、中畑則道
- Organizer
  2009年科学研究費特定領域班会議
- Place of Presentation
  千葉
- Year and Date
  2009-09-10
- Data Source
  KAKENHI-PROJECT-20790053
[Presentation] Gタンパク質関連シグナルに対するスズメバチ毒素マストパランの2つの作用-Gαシグナルの抑制とGβγシグナルの活性化-2008
- Author(s)
  須釜淳、小原祐太郎、中畑則道
- Organizer
  第31回日本分子生物学会、第81回日本生化学会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-20054002
[Presentation] PC12細胞におけるERK5の生理的な役割について2008
- Author(s)
  山内新、○小原祐太郎、竹原伸、Philip Stork、中畑則道
- Organizer
  科学研究費特定領域班会議
- Place of Presentation
  新潟
- Data Source
  KAKENHI-PROJECT-20790053
[Presentation] NGFの神経細胞の形態的・機能的な分化誘導作用とERK5の役割について2008
- Author(s)
  山内新、○小原祐太郎、竹原伸、中畑則道
- Organizer
  東北大学若手萌芽研究発表会
- Place of Presentation
  仙台
- Year and Date
  2008-07-16
- Data Source
  KAKENHI-PROJECT-20790053
[Presentation] トロンボキサンA_2受容体を介するEGF受容体のトランスアクチベーション機構の解明2008
- Author(s)
  内山琴美、佐々木雅子、斎藤将樹、小原祐太郎、東山繁樹、中畑則道
- Organizer
  第81回日本薬理学会年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-18057002
[Presentation] PC12細胞におけるERK5の生理的な意義について2008
- Author(s)
  山内新、小原祐太郎Philip Stork、中畑則道
- Organizer
  科学研究費特定領域班会議
- Place of Presentation
  新潟
- Year and Date
  2008-09-19
- Data Source
  KAKENHI-PROJECT-20790053
[Presentation] βγ subunits of Gi/o suppress epidermal growth factor-induced phosphorylation of extracellular signal-regulated kinase 5, whereas they enhance phosphorylation of extracellular signal-regulated kinase 1/2.2008
- Author(s)
  岡野優美子、小野幸子、○小原祐太郎、山内新、星野智洋、黒瀬等、中畑則道
- Organizer
  第81回日本薬理学会年会
- Place of Presentation
  横浜
- Year and Date
  2008-03-18
- Data Source
  KAKENHI-PROJECT-18790039
[Presentation] cAMPおよびCa^<2+>誘発性のERK活性化における低分子量Gタンパク質RasとRap1の関与について2007
- Author(s)
  ○小原祐太郎、Angela Horgan、中畑則道、Philip Stork
- Organizer
  2007日本生化学会・日本分子生物学会合同年会
- Place of Presentation
  横浜
- Year and Date
  2007-12-13
- Data Source
  KAKENHI-PROJECT-18790039
[Presentation] 小脳顆粒神経細胞におけるcAMPおよびCa^<2+>誘発性のERK活性化に関する低分子量Gタンパク質RasとRap1の関与について2007
- Author(s)
  ○小原祐太郎、Angela Horgan、中畑則道、Philip Stork
- Organizer
  第6回生命科学研究会
- Place of Presentation
  千葉
- Year and Date
  2007-07-06
- Data Source
  KAKENHI-PROJECT-18790039
[Presentation] A synthetic cannabinoid, CP55940, inhibits LPS-induced cytokine production in a CB_1-independent manner in rat cerebellar granulecells.2007
- Author(s)
  ○小原祐太郎、千葉俊樹、中畑則道
- Organizer
  第37回神経科学学会 2007年11月
- Place of Presentation
  サンディエゴ(アメリカ)
- Year and Date
  2007-11-07
- Data Source
  KAKENHI-PROJECT-18790039
[Presentation] ERK5 regulates catecholamine biosynthesis and homeostasis in neural cells and human adrenal medullas.
- Author(s)
  小原　祐太郎、長澤　隆介、根本　亙、Mike J. Pellegrino、高橋　麻穂、Beth A Habecker、Philip J.S Stork、一柳　統、伊藤　裕美、冨田　善彦、石井　邦明、中畑　則道
- Organizer
  第87回　日本薬理学会年会
- Place of Presentation
  名古屋国際会議場（名古屋）
- Year and Date
  2015-03-18 – 2015-03-20
- Data Source
  KAKENHI-PROJECT-24790063
[Presentation] ERK5とERK1/2のクロストーク機構について
- Author(s)
  小原　祐太郎、本多　拓人、山内　新、Anthony D. Couvillon、Justin J. Mason、石井　邦明、中畑　則道
- Organizer
  第65回　日本薬理学会北部会
- Place of Presentation
  コラッセ福島（福島）
- Year and Date
  2014-09-26 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-24790063

1. NAKAGAWASAI Osamu (50296018)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
2. 中畑則道 (60045804)

# of Collaborated Projects: 2 results

# of Collaborated Products: 23 results
3. 守屋孝洋 (80298207)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. 斎藤将樹 (50400271)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
5. TAN-NO Koichi (20207260)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. 小野木弘志 (50610200)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 根本亙 (80635136)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
8. 石井邦明 (10184459)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. 中島修 (80312841)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 太田康之 (20746854)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. ICHIYANAGI Osamu

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
12. STORK Philip

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
13. HABECKER Beth

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
14. 岡本洋介

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Obara Yutaro 小原 祐太郎

OBARA YUTARO 小原 祐太郎

OBARA Yutaro 小原 祐太郎

Research Projects

Research Products

Co-Researchers

パーキンソン病のリスク遺伝子Midnolinの分子機能と生理的な役割の解明Principal Investigator

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パーキンソン病の新しいリスク遺伝子Midnolin（MIDN）の分子基盤の構築Principal Investigator

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Pathophysiological significance of decreased K channel expression by receptor activation

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Clarification of pathophysiological roles of MIDN, a novel genetic risk factor for Parkinson's diseasePrincipal Investigator

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Pathophysiological roles of ERK5 in catecholamine biosynthesisPrincipal Investigator

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Development of hippocampal neurogenesis-promoting drugs as a target for the treatment and prevention of psychiatric disorders

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Novel molecular mechanism of neuronal functions by ERK5Principal Investigator

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三量体Gタンパク質αサブユニットの脂質ラフト局在と脂質修飾に関する研究

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Clarification of novel physiological roles of ERK5 in neuronsPrincipal Investigator

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三量体Gタンパク質の脂質ラフト局在と活性調節の分子メカニズムに関する研究

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新しい作用機序を有する天然由来抗痴呆症薬の研究Principal Investigator

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[Journal Article] Structural Variants of <i>Midnolin</i>, a Genetic Risk Factor for Parkinson’s Disease, in a Yamagata Cohort2023

Author(s)

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Obara Yutaro 小原祐太郎

OBARA YUTARO 小原祐太郎

OBARA Yutaro 小原祐太郎