OHNO MASASUKE 大野真佐輔

… Alternative Names

Ohno Masasuke 大野真佐輔

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Researcher Number	40402606
Other IDs
Affiliation (Current)	2025: 愛知県がんセンター(研究所), 腫瘍免疫応答研究分野, 研究員
Affiliation (based on the past Project Information) *help	2022 – 2025: 愛知県がんセンター(研究所), 分子診断TR分野, 研究員 2013 – 2015: 独立行政法人国立病院機構(名古屋医療センター臨床研究センター), その他部局等, その他
Review Section/Research Field	Principal Investigator Basic Section 56010:Neurosurgery-related / Neurosurgery Except Principal Investigator Basic Section 56010:Neurosurgery-related / Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
Keywords	Principal Investigator 免疫療法 / 脳腫瘍 / 腫瘍免疫 / 腫瘍浸潤B細胞 / 三次リンパ構造 / 癌微小免疫環境 / 転移性脳腫瘍 / 遺伝子療法 / 免疫抑制 / 養子免疫療法 … More / 細胞療法 / 国際発表　アメリカ合衆国 / microRNA / 遺伝子治療 / immunotherapy / podplanin / immune modulator drugs / CAR T-Cell Therapy / micro RNA / gene therapy / immunomodulatory drug / glioblastoma / CAR / cancer immunotherapy … More Except Principal Investigator 脳腫瘍 / CAR-T細胞療法 / 免疫療法 / 腫瘍関連B細胞 / 三次元リンパ構造 / CAR-T療法 / 肺癌 / 転移性脳腫瘍 / CAR-T細胞 / AI病理 / 三次リンパ構造 / キメラ受容体抗体 / 抗体取得 / 胃癌 / PCNSL / リンパ腫 / 異所性リンパ組織 / 腫瘍微小環境 / 腫瘍免疫 / 髄膜腫 Less

転移性脳腫瘍における三次リンパ構造由来抗体を用いたCAR-T細胞療法の開発Principal Investigator
- Principal Investigator
  
  大野真佐輔
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Aichi Cancer Center Research Institute
難治性髄膜腫におけるがん免疫微小環境の解明
- Principal Investigator
  
  伊藤英治
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Aichi Medical University
Elucidation of the Pathological Significance of CD276 Expression in M2 Macrophages in Primary Central Nervous System Lymphoma
- Principal Investigator
  
  吉岡宏真
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Kindai University
Establishment of a platform for high-throughput CAR-T cell generation for gastric cancer
- Principal Investigator
  
  掛地吉弘
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
- Research Institution
  Kobe University
転移性脳腫瘍の制御を目的としたCAR-T細胞療法の開発に関する研究
- Principal Investigator
  
  奥田武司
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Kindai University
腫瘍微小環境内 B 細胞を用いた転移性脳腫瘍に対する CAR-T 細胞療法の開発Principal Investigator
- Principal Investigator
  
  大野真佐輔
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Aichi Cancer Center Research Institute
The development of immunotherapy in malignant brain tumor to overcome cancer immunosuppression and immune evasionPrincipal Investigator
- Principal Investigator
  
  Ohno Masasuke
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurosurgery
- Research Institution
  National Hospital Organization Nagoya Medical Center

All 2023 2022 2016 2015 2013 Other

All Journal Article Presentation

[Journal Article] Brain metastasis and intracranial leptomeningeal metastasis from malignant peripheral nerve sheath tumors: illustrative cases2023
- Author(s)
  Ohno Masasuke、Haimoto Shoichi、Tsukushi Satoshi、Hosoda Waki、Ohka Fumiharu、Saito Ryuta
- Journal Title
  
  Journal of Neurosurgery: Case Lessons
  
  Volume: 6 Issue: 3
- DOI
  10.3171/case23148
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K09223
[Journal Article] <i>CD79B</i> <scp>Y196</scp> mutation is a potent predictive marker for favorable response to <scp>R‐MPV</scp> in primary central nervous system lymphoma2022
- Author(s)
  Yamaguchi Junya、Ohka Fumiharu、Ohno Masasuke、Saito Ryuta、et.al.
- Journal Title
  
  Cancer Medicine
  
  Volume: 12 Issue: 6 Pages: 7116-7126
- DOI
  10.1002/cam4.5512
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K09223, KAKENHI-PROJECT-20K20598, KAKENHI-PROJECT-20H03511, KAKENHI-PROJECT-21H03039
[Journal Article] Efficacy of cancer-specific anti-podoplanin CAR-T cells and oncolytic herpes virus G47Δ combination therapy against glioblastoma2022
- Author(s)
  Chalise Lushun、Kato Akira、Ohno Masasuke、Maeda Sachi、Yamamichi Akane、Kuramitsu Shunichiro、Shiina Satoshi、Takahashi Hiromi、Ozone Sachiko、Yamaguchi Junya、Kato Yukinari、Rockenbach Yumi、Natsume Atsushi、Todo Tomoki
- Journal Title
  
  Molecular Therapy - Oncolytics
  
  Volume: 26 Pages: 265-274
- DOI
  10.1016/j.omto.2022.07.006
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K09223, KAKENHI-PROJECT-22H00483, KAKENHI-PROJECT-19KK0228, KAKENHI-PROJECT-20H03789, KAKENHI-PLANNED-17H06356
[Journal Article] Primary central nervous system malignant lymphoma in a patient with rheumatoid arthritis receiving tocilizumab: illustrative case2022
- Author(s)
  Ohno Masasuke、Kuramitsu Shunichiro、Iwakoshi Akari、Yamaguchi Junya、Ohka Fumiharu、Saito Ryuta
- Journal Title
  
  Journal of Neurosurgery: Case Lessons
  
  Volume: 4 Issue: 6
- DOI
  10.3171/case22256
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K09223
[Journal Article] CAR T Cells Targeting Podoplanin Reduce Orthotopic Glioblastomas in Mouse Brains2016
- Author(s)
  Shiina S, Ohno M, Ohka F, Kuramitsu S, Yamamichi A, Kato A, Motomura K, Tanahashi K, Yamamoto T, Watanabe R, Ito I, Senga T, Hamaguchi M, Wakabayashi T, Kaneko MK, Kato Y, Chandramohan V, Bigner DD, Natsume A
- Journal Title
  
  Cancer immunology research
  
  Volume: 4 Issue: 3 Pages: 259-268
- DOI
  10.1158/2326-6066.cir-15-0060
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25861270
[Journal Article] Lenalidomide enhances the function of chimeric antigen receptor T cells against the epidermal growth factor receptor variant III by enhancing immune synapses2015
- Author(s)
  Kuramitsu S, Ohno M, Ohka F, Shiina S, Yamamichi A, Kato A, Tanahashi K, Motomura K, Kondo G, Kurimoto M, Senga T, Wakabayashi T, Natsume A
- Journal Title
  
  Cancer Gene Therpy
  
  Volume: 22 Issue: 10 Pages: 487-495
- DOI
  10.1038/cgt.2015.47
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25861270
[Journal Article] Expression of miR-17-92 enhances anti-tumor activity of T-cells transduced with the anti-EGFRvIII chimeric antigen receptor in mice bearing human GBM xenografts2013
- Author(s)
  Masasuke Ohno, Takayuki Ohkuri, Akemi Kosaka, Kuniaki Tanahashi, Carl H June, Atsushi Natsume, Hideho Okada
- Journal Title
  
  Journal for ImmunoTherapy of Cancer
  
  Volume: 1 Issue: 1 Pages: 112-112
- DOI
  10.1186/2051-1426-1-21
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25861270
[Presentation] 転移性脳腫瘍における腫瘍免疫微小環境について2023
- Author(s)
  野平翔太、大野真佐輔、本村和也、大岡史治、灰本章一、齋藤竜太
- Organizer
  第41回日本脳腫瘍学会学術集会
- Data Source
  KAKENHI-PROJECT-22K09223
[Presentation] 消化器癌の脳転移における三次リンパ構造およびがん免疫微小環境の解析2023
- Author(s)
  大野真佐輔
- Organizer
  第27回日本バイオ治療法学会学術集会
- Data Source
  KAKENHI-PROJECT-22K09223
[Presentation] 肺がん転移性脳腫瘍における三次リンパ構造と臨床的予後の関連性2023
- Author(s)
  野平翔太、大野真佐輔、藤田貢、松下博和、齋藤竜太
- Organizer
  第27回日本バイオ治療法学会学術集会
- Data Source
  KAKENHI-PROJECT-22K09223
[Presentation] 消化器癌の転移性脳腫瘍における三次リンパ構造の解析2023
- Author(s)
  大野真佐輔、山下公大、倉光俊一郎、長坂暢、灰本章一、藤田貢
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-22K09223
[Presentation] 転移性脳腫瘍における癌免疫微小環境の解析2023
- Author(s)
  大野真佐輔、藤田貢、松下博一、長坂暢、山下公大、倉光俊一郎、野平翔太、灰本章一、齋藤竜太
- Organizer
  第41回日本脳腫瘍学会学術集会
- Data Source
  KAKENHI-PROJECT-22K09223
[Presentation] 消化器癌の脳転移におけるがん免疫微小環境の解析2023
- Author(s)
  大野真佐輔、藤田貢、山下公大、長坂暢、倉光俊一郎、野平翔太、灰本章一、松下博和、齋藤竜太
- Organizer
  第23回日本分子脳神経外科学会
- Data Source
  KAKENHI-PROJECT-22K09223
[Presentation] 頭蓋内転移を認めた悪性末梢神経鞘腫の2例2022
- Author(s)
  大野真佐輔
- Organizer
  第40回日本脳腫瘍学会学術集会
- Data Source
  KAKENHI-PROJECT-22K09223
[Presentation] GBMに対する化学療法による低免疫環境に耐性を持つ遺伝子改変T細胞療法の開発2013
- Author(s)
  大野真佐輔大栗敬幸小坂朱棚橋邦明若林俊彦夏目敦至岡田秀穂
- Organizer
  第31回日本脳腫瘍学会学術集会
- Place of Presentation
  宮崎県宮崎市山崎町浜山フェニックス・シーガイア・リゾート
- Data Source
  KAKENHI-PROJECT-25861270
[Presentation] EGFRｖIII特異的キメラ抗原レセプターを発現するT細胞へのmiR-17-92遺伝子導入はマウスGBMモデルにおいて抗腫瘍活性を増強させる2013
- Author(s)
  大野真佐輔大栗敬幸小坂朱棚橋邦明若林俊彦夏目敦至岡田秀穂
- Organizer
  第72回日本脳神経外科学会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-25861270
[Presentation] Podoplanin 特異的キメラ抗原受容体を発現する T 細胞の GBM に対する抗腫瘍効果の検討
- Author(s)
  椎名諭、夏目敦至、大野真佐輔、倉光俊一郎、加藤幸成、Darell D. Bigner、若林俊彦
- Organizer
  第32回日本脳腫瘍学会学術集会
- Place of Presentation
  千葉県浦安市舞浜
- Year and Date
  2014-11-30 – 2014-12-02
- Data Source
  KAKENHI-PROJECT-25861270
[Presentation] GBMに対するPodoplanin特異的キメラ抗原受容体を発現するT細胞の抗腫瘍効果の検討
- Author(s)
  椎名諭、夏目敦至、大野真佐輔、倉光俊一郎、加藤幸成、Darell D. Bigner、若林俊彦
- Organizer
  日本脳神経外科学会第73回学術総会
- Place of Presentation
  東京都港区高輪
- Year and Date
  2014-10-09 – 2014-10-11
- Data Source
  KAKENHI-PROJECT-25861270
[Presentation] Expression of miR-17-92 enhances anti-tumor activity of T-cells transduced with the anti-EGFRvIII chimeric antigen receptor in mice bearing human GBM xenografts
- Author(s)
  Masasuke Ohno, Takayuki Ohkuri, Akemi Kosaka, Carl H. June, Atsushi Natusme, Hideho Okada
- Organizer
  American Association for Cancer Research（AACR）, Annual Meeting 2014
- Place of Presentation
  San Diego, CA, U.S.A
- Year and Date
  2014-04-05 – 2014-04-09
- Data Source
  KAKENHI-PROJECT-25861270
[Presentation] 免役シナプスを強化する lenalidomide と EGFRvIII キメラ抗原受容体発現 T 細胞の併用効果
- Author(s)
  倉光俊一郎、夏目敦至、大野真佐輔、椎名諭、若林俊彦
- Organizer
  第32回日本脳腫瘍学会学術集会
- Place of Presentation
  千葉県浦安市舞浜
- Year and Date
  2014-11-30 – 2014-12-02
- Data Source
  KAKENHI-PROJECT-25861270

1. 藤田貢 (40609997)

# of Collaborated Projects: 5 results

# of Collaborated Products: 4 results
2. 山下公大 (80535427)

# of Collaborated Projects: 4 results

# of Collaborated Products: 3 results
3. 中野秀雄 (00237348)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. 倉光俊一郎 (90972844)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
5. NATSUME Atsushi (30362255)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
6. 松下博和 (80597782)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
7. 伊藤英治 (30402605)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 大岡史治 (10725724)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 吉岡宏真 (70617381)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 坂本万寿夫 (20580773)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 中田晋 (80590695)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 掛地吉弘 (80284488)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 船越洋平 (50566966)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 奥田武司 (10340796)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. OKADA Hideho

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
16. SHIINA Satoshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results

OHNO MASASUKE 大野 真佐輔

Ohno Masasuke 大野 真佐輔

Research Projects

Research Products

Co-Researchers

転移性脳腫瘍における三次リンパ構造由来抗体を用いたCAR-T細胞療法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

難治性髄膜腫におけるがん免疫微小環境の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the Pathological Significance of CD276 Expression in M2 Macrophages in Primary Central Nervous System Lymphoma

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishment of a platform for high-throughput CAR-T cell generation for gastric cancer

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

転移性脳腫瘍の制御を目的としたCAR-T細胞療法の開発に関する研究

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

腫瘍微小環境内 B 細胞を用いた転移性脳腫瘍に対する CAR-T 細胞療法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The development of immunotherapy in malignant brain tumor to overcome cancer immunosuppression and immune evasionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Brain metastasis and intracranial leptomeningeal metastasis from malignant peripheral nerve sheath tumors: illustrative cases2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] <i>CD79B</i> <scp>Y196</scp> mutation is a potent predictive marker for favorable response to <scp>R‐MPV</scp> in primary central nervous system lymphoma2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Efficacy of cancer-specific anti-podoplanin CAR-T cells and oncolytic herpes virus G47Δ combination therapy against glioblastoma2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Primary central nervous system malignant lymphoma in a patient with rheumatoid arthritis receiving tocilizumab: illustrative case2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CAR T Cells Targeting Podoplanin Reduce Orthotopic Glioblastomas in Mouse Brains2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Lenalidomide enhances the function of chimeric antigen receptor T cells against the epidermal growth factor receptor variant III by enhancing immune synapses2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Expression of miR-17-92 enhances anti-tumor activity of T-cells transduced with the anti-EGFRvIII chimeric antigen receptor in mice bearing human GBM xenografts2013

Author(s)

Journal Title

OHNO MASASUKE 大野真佐輔

Ohno Masasuke 大野真佐輔