KOBAYASHI Katsuki 小林克樹

Researcher Number	40415451
Affiliation (based on the past Project Information) *help	2011: 独立行政法人国立病院機構(千葉東病院臨床研究センター), 遺伝子解析, 診断研究室長 2011: 独立行政法人国立病院機構千葉東病院, 臨床研究センター, 室長 2009 – 2010: 独立行政法人国立病院機構(千葉東病院臨床研究センター), 遺伝子解析・診断研究室, 室長 2007 – 2009: 国立病院機構千葉東病院, 臨床研究センター, 室長 2008: Clinical research Center, Chiba-East National Hospital, National Hospital Organization, 臨床研究センター病態機能研究部, 室長 … More 2008: Clinical research Center, Chiba-East National Hospital, National Hospital Organization, 千葉東病院臨床研究センター, 室長 2007: Clinical research Center, Chiba-East National Hospital, National Hospital Organization, 分子生物研究部, 遺伝子解析・診断研究室長 2006: 独立行政法人国立病院機構, 千葉東病院臨床研究センタ・分子生物研究部, 室長 2006: 独立行政法人国立病院機構, 千葉東病院臨床研究センター・分子生物研究部遺伝子解析・診断研究室, 室長 2006: Chiba East Hospital, Ibido, sub-chief, 室長 2005: 独立行政法人国立病院機構(千葉東病院臨床研究センター), 遣伝子解析・診断研究室長 Less
Review Section/Research Field	Principal Investigator Kidney internal medicine Except Principal Investigator Kidney internal medicine
Keywords	Principal Investigator AQP11 / 多発性嚢胞腎 / AQPll / CFTR / ERストレス / アポトーシス / ER stress / aquaporin-11 / PKD / アクアポリン … More / ラパマイシン / mTOR / primary cilia / 小胞体ストレス / 多発性蓑胞腎 … More Except Principal Investigator PCR / SNP / アクアポリン / 水チャネル / exon / mutation / genome sequenceing / glycerol channel / water channel / aquaporin / スプライスバリアント / エクソン / 偽遺伝子 / ヒトゲノム / エキソン / アミノ酸置換 / ゲノム解析 / グリセリンチャネル / 膜蛋白質 / グリセロール / チャネル / プロテオミクス / 細胞内輸送 / 酵母two-hybrid法 / AKAP / リト脂質結合蛋 / 遺伝子改変マウス / 蛍光相関分光 / トロポミオシン / アクチン / リン脂質結合蛋白 / 嚢胞腎 / 膵炎 / 尿崩症 / 水輸送 Less

Eendoplasmic reticulum stress is involved in the pathogenesisi of polycystic kidneydieasePrincipal Investigator
- Principal Investigator
  
  KOBAYASHI Katsuki
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Clinical research Center, Chiba-East National Hospital, National Hospital Organization
A study of the cystogenesis in the AQP11 knockout mouse kidneyPrincipal Investigator
- Principal Investigator
  
  小林克樹
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Clinical research Center, Chiba-East National Hospital, National Hospital Organization
Function and regulatory system of water transporting aquaporin channels
- Principal Investigator
  
  SASAKI Sei
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Creative Scientific Research
- Research Institution
  Tokyo Medical and Dental University
Genomic Analysis of Human Aquaporin Genes
- Principal Investigator
  
  ISHIBASHI Kenichi
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Clinical Research Center, Chiba National Hospital

All 2011 2010 2009 2008 2007 2006 2005

All Journal Article Presentation

[Journal Article] 多発性嚢胞腎と遺伝子異常2008
- Author(s)
  小林克樹, 香村衡一
- Journal Title
  
  Urological View 6
  
  Pages: 61-65
- Data Source
  KAKENHI-PROJECT-18590919
[Journal Article] Proximal tubule cyst formation of AQP11 knockout mice : roles of apoptosis and mTOR signaling pathway.2006
- Author(s)
  Kobayashi K et al.
- Journal Title
  
  Journal of American Society of Nephrology 17
- Data Source
  KAKENHI-PROJECT-18590919
[Journal Article] Wnt4-transformed mouse embryonic stem cells differentiate into renal tubular cells.2005
- Author(s)
  Kobayashi T, et al.
- Journal Title
  
  Biochem. Biophys. Res. Commun. 336
  
  Pages: 585-595
- Data Source
  KAKENHI-PROJECT-17GS0312
[Journal Article] Disruption of aquaporin-11 produces polycystic kidneys following vacuolization of the proximal tubule.2005
- Author(s)
  Morishita Y, Matsuzaki T, Hara-chikuma M, Andoo A, Shimono M, Matsuki A, KobayashiK, Ikeda M, Yamamoto T, Verkman AS, Kusano E, Ookawara S, Takata K, Sasaki S, Ishibashi K
- Journal Title
  
  Mol. Cell. Biol. 25
  
  Pages: 7770-7779
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590854
[Journal Article] Disruption of aquaporin-11 produces polycystic kidneys following vacuolization of the proximal tubule.2005
- Author(s)
  Morishita Y, Matsuzaki T, Hara-chikuma M, Andoo A, Shimono M, Matsuki A, Kobayashi K, Ikeda M, Yamamoto T, Verkman AS, Kusano E, Ookawara S, Takata K, Sasaki S, Ishibashi K
- Journal Title
  
  Mol. Cell. Biol. 25
  
  Pages: 7770-7779
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590854
[Journal Article] Disruption of aquaporin-11 produces polycystic kidneys following vacuolization of the proximal tubule2005
- Author(s)
  Morishita Y, Matsuzaki T, Hara-Chikuma M, Ando A, Shimono M, Matsuki A, Kobayashi K, Ikeda M, Yamamoto T, Verkman A, Kusano E, Ookawara S, Takata K, Sasaki S, Ishibashi K.
- Journal Title
  
  Mol Cell Biol. 25
  
  Pages: 7770-7779
- Data Source
  KAKENHI-PROJECT-17GS0312
[Presentation] Disruption of Mouse AQP11 Induces Endoplasmic Reticulum Stress, Followedby Apoptosis and Cellular Proliferation, in the Proximal Tubule Cells of the Kidney2011
- Author(s)
  Katsuki Kobayashi, Sei Sasaki
- Organizer
  ASN Renal Week 2010
- Place of Presentation
  米国コロラド州デンバー
- Year and Date
  2011-11-19
- Data Source
  KAKENHI-PROJECT-21591050
[Presentation] CFTRis Highly Expressed in the Cyst-Lining Epithelial Cells ofthe AQP11 Knockout MouseKidney2011
- Author(s)
  Denver, COKatsuki Kobayashi, et al
- Organizer
  Kidney Week
- Place of Presentation
  Philadelphia, PA
- Data Source
  KAKENHI-PROJECT-21591050
[Presentation] Disruption of Mouse AQP11 Induces Endoplasmic Reticulum Stress, Followed by Apoptosis and Cellular Proliferation, in the Proximal Tubule Cells of the Kidney2011
- Author(s)
  Katsuki Kobayashi, Sei Sasaki
- Organizer
  ASN Renal Week 2010
- Place of Presentation
  米国コロラド州デンバー
- Year and Date
  2011-11-19
- Data Source
  KAKENHI-PROJECT-21591050
[Presentation] hly Expressed in the Cyst-Lininng Epithelial Cells of the AQP11 Knockout M2011
- Author(s)
  Katsuki Kobayashi, et al
- Organizer
  Kidney Week 2011
- Place of Presentation
  Philadelphia, PA
- Data Source
  KAKENHI-PROJECT-21591050
[Presentation] AQP11の欠損は近位尿細管の異なる部位にアポトーシスと細胞増殖を別々に誘導する2010
- Author(s)
  小林克樹、品田絵美、内田信一、佐々木成
- Organizer
  第53回日本腎臓学会学術集会
- Place of Presentation
  神戸
- Year and Date
  2010-06-18
- Data Source
  KAKENHI-PROJECT-21591050
[Presentation] AQP11の欠損は近位尿細管の異なる部位にアポトーシスと細胞増殖を別々に誘導する。2010
- Author(s)
  小林克樹、品田絵美、内田信一、佐々木成
- Organizer
  第53回日本腎臓学会学術集会
- Place of Presentation
  神戸
- Year and Date
  2010-06-18
- Data Source
  KAKENHI-PROJECT-21591050
[Presentation] Disruption of Mouse AQP11Induces Endoplasmic ReticulumStess, Followed by Apoptosisand Cellular Proliferation, in the Proximal Tubule Cells ofthe Kidney2010
- Author(s)
  San Diego CAKatsuki Kobayashi, et al
- Organizer
  Renal Week
- Place of Presentation
  Denver, CO
- Data Source
  KAKENHI-PROJECT-21591050
[Presentation] Lossof Aquaporin-11 Causes Both theApoptosis and the Enhanced CellProliferation of the RenalProximal tubule Cells2009
- Author(s)
  Katsuki Kobayashi, et al
- Organizer
  Renal Week
- Place of Presentation
  San Diego CA
- Data Source
  KAKENHI-PROJECT-21591050
[Presentation] AQP11ノックアウトマウスにおける primary cilia の解析2009
- Author(s)
  小林克樹
- Organizer
  第52回日本腎臓学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-17GS0312
[Presentation] Loss of Aquaporin-11 causes both the apoptosis and the enhanced cell proliferation of the renal proximal tubule cells2009
- Author(s)
  小林克樹
- Organizer
  The 42nd Annual Meeting of American Society of Nephrology
- Place of Presentation
  San Diego, USA
- Data Source
  KAKENHI-PROJECT-17GS0312
[Presentation] The Primary Cilia of The AQP11 Knockout Mouse Kidney2008
- Author(s)
  Kobayashi K, Uchida S, Sasaki S
- Organizer
  Renal Week
- Place of Presentation
  Philadelphia, PA
- Data Source
  KAKENHI-PROJECT-18590919
[Presentation] The Primary Cilia of The AQP11 Knockout Mouse Kidney2008
- Author(s)
  Kobayashi K, Uchida S, Sasaki S.
- Organizer
  Renal Week 2008
- Place of Presentation
  Philadelphia, PA, USA
- Data Source
  KAKENHI-PROJECT-18590919
[Presentation] The primary cilia of the AQP11 knockout mouse kidney.2008
- Author(s)
  Kobayashi K
- Organizer
  The 41^<st> Annual meeting of AmericanSociety of Nephrology
- Place of Presentation
  フィラデルフィア
- Data Source
  KAKENHI-PROJECT-17GS0312
[Presentation] Neonatal kidney of AQP11-disrupted mice exhibit ER stress-induced apoptosis of the proximal tubules followed by a remarkable slowing of cyst-formation by rapamycin treatment.2007
- Author(s)
  Kobayashi K, et. al.
- Organizer
  The 5th International Conference of Aquaporin
- Place of Presentation
  Nara, Japan
- Year and Date
  2007-07-14
- Data Source
  KAKENHI-PROJECT-17GS0312
[Presentation] Neonatal kidneys of AQP11-disrupted mice exhibit enhanced apotosis followed by a remarkable slowing of cyst-formation by rapamycin treatment2007
- Author(s)
  Kobayashi K, Ishibashi K, Sasaki S.
- Organizer
  The 5^<th> International Conference of Aquaporin
- Place of Presentation
  Nara
- Data Source
  KAKENHI-PROJECT-17GS0312
[Presentation] Neonatal Kidneys of AQP11-Disrupted Mice Exhibit Enhanced Apoptosis Followed by a Remarkable Slowing of Cyst-formation by Rapamycin Treatment2007
- Author(s)
  Nara Katsuki Kobayashi Kenichi Ishibashi and Sei Sasaki
- Organizer
  The 5~<the> International Conference of Aquaporin
- Place of Presentation
  Nara Centennial Hall
- Data Source
  KAKENHI-PROJECT-18590919
[Presentation] Neonatal kidney of AQP11-disrupted mice exhibit ER stress-induced apoptosis of the proximal tubules followed by a remarkable slowing of cyst-formation by rapamycin treatment.2007
- Author(s)
  Kobayashi K, et. al.
- Organizer
  ASN(American Society of Nephrology) Renal Week 2007
- Place of Presentation
  San Francisco, USA
- Year and Date
  2007-11-02
- Data Source
  KAKENHI-PROJECT-17GS0312
[Presentation] AQP11ノックアウトマウスののう胞形成におけるアポトーシスの役割(0-257)2007
- Author(s)
  小林克樹、石橋賢一、佐々木成
- Organizer
  第50回日本腎臓学会学術総会
- Place of Presentation
  アクトシティ浜松
- Data Source
  KAKENHI-PROJECT-18590919
[Presentation] Neonatal Kidneys of AQP11-Disprupted Mice Exhibit ER Stress-Induced Apoptosis of the Proximal Tubules Followed by Repamycin Treatment(F-P0013)2007
- Author(s)
  Katsuki Kobayashi, Kenichi Ishibashi, Sei Sasaki
- Organizer
  ASN Renal Week
- Place of Presentation
  Moscone Center Francisco, California
- Data Source
  KAKENHI-PROJECT-18590919
[Presentation] Neonatal Kidneys of AQP11-Disrupted Mice Exhibit Enhanced Apoptosis Followed by a Remarkable Slowing of Cyst-formation by Rapamycin Treatment.2007
- Author(s)
  Kobayashi K, et. al.
- Organizer
  The 5th International Conference of Aquaporin
- Place of Presentation
  Nara, Japan
- Year and Date
  2007-07-15
- Data Source
  KAKENHI-PROJECT-17GS0312
[Presentation] AQP11ノックアウトマウスののう胞形成におけるアポトーシスの役割2007
- Author(s)
  小林克樹, ほか
- Organizer
  第50回日本腎臓学会学術総会
- Place of Presentation
  静岡県浜松市
- Year and Date
  2007-05-26
- Data Source
  KAKENHI-PROJECT-17GS0312
[Presentation] Neonatal Kidneys of AQP11-Disrupted Mice Exhibit ER stress-Induced Apoptosis of the Pr2007
- Author(s)
  Katsuki Kobayashi, et. al.
- Organizer
  Renal Week2007
- Place of Presentation
  San Francisco,California
- Data Source
  KAKENHI-PROJECT-18590919
[Presentation] rapamycinはAQP11ノックアウトマウスにおいても蓑胞形成を抑制する2006
- Author(s)
  小林克樹、祭原幸子、石橋賢一
- Organizer
  第14回蓑胞性腎疾患研究会
- Place of Presentation
  東京
- Year and Date
  2006-09-09
- Data Source
  KAKENHI-PROJECT-18590919
[Presentation] Proximal tubule cyst formation of AQP11 knockout mice: roles of apoptosis and mTOR signaling pathway(SA-P0968)2006
- Author(s)
  Katsuki Kobayashi et al
- Organizer
  ASN Renal Week 2006
- Place of Presentation
  San Diego Convention Center
- Data Source
  KAKENHI-PROJECT-18590919
[Presentation] APQ11ノックアウトマウスのう胞腎形成における細胞増殖・アポトーシスの検討2006
- Author(s)
  小林克樹
- Organizer
  日本腎臓学会第49回日本腎臓学会学術総会 P164
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-18590919

1. ISHIBASHI Kenichi (80223022)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
2. SASAKI Sei (60170677)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
3. UCHIDA Sinichi (50262184)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. NODA Yumi (30372436)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 山田研一

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

KOBAYASHI Katsuki 小林 克樹

Research Projects

Research Products

Co-Researchers

Eendoplasmic reticulum stress is involved in the pathogenesisi of polycystic kidneydieasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A study of the cystogenesis in the AQP11 knockout mouse kidneyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Function and regulatory system of water transporting aquaporin channels

Principal Investigator

Project Period (FY)

Research Category

Research Institution

Genomic Analysis of Human Aquaporin Genes

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] 多発性嚢胞腎と遺伝子異常2008

Author(s)

Journal Title

Data Source

[Journal Article] Proximal tubule cyst formation of AQP11 knockout mice : roles of apoptosis and mTOR signaling pathway.2006

Author(s)

Journal Title

Data Source

[Journal Article] Wnt4-transformed mouse embryonic stem cells differentiate into renal tubular cells.2005

Author(s)

Journal Title

Data Source

[Journal Article] Disruption of aquaporin-11 produces polycystic kidneys following vacuolization of the proximal tubule.2005

Author(s)

Journal Title

Description

Data Source

[Journal Article] Disruption of aquaporin-11 produces polycystic kidneys following vacuolization of the proximal tubule.2005

Author(s)

Journal Title

Description

Data Source

[Journal Article] Disruption of aquaporin-11 produces polycystic kidneys following vacuolization of the proximal tubule2005

Author(s)

Journal Title

Data Source

[Presentation] Disruption of Mouse AQP11 Induces Endoplasmic Reticulum Stress, Followedby Apoptosis and Cellular Proliferation, in the Proximal Tubule Cells of the Kidney2011

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] CFTRis Highly Expressed in the Cyst-Lining Epithelial Cells ofthe AQP11 Knockout MouseKidney2011

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] Disruption of Mouse AQP11 Induces Endoplasmic Reticulum Stress, Followed by Apoptosis and Cellular Proliferation, in the Proximal Tubule Cells of the Kidney2011

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] hly Expressed in the Cyst-Lininng Epithelial Cells of the AQP11 Knockout M2011

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] AQP11の欠損は近位尿細管の異なる部位にアポトーシスと細胞増殖を別々に誘導する2010

Author(s)

Organizer

Place of Presentation

Year and Date

KOBAYASHI Katsuki 小林克樹