Takeda Norihiko 武田憲彦

… Alternative Names

TAKEDA NORIHIKO 武田憲彦

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Researcher Number	40422307
Other IDs
Affiliation (Current)	2025: 東京大学, 医学部附属病院, 教授 2025: 自治医科大学, 医学部, 非常勤講師
Affiliation (based on the past Project Information) *help	2023 – 2025: 東京大学, 医学部附属病院, 教授 2023 – 2024: 自治医科大学, 医学部, 非常勤講師 2020 – 2023: 自治医科大学, 医学部, 教授 2017 – 2019: 東京大学, 医学部附属病院, 助教 2014 – 2018: 東京大学, 医学部附属病院, 特任講師 … More 2015: 東京大学, 医学部附属病院, 講師 2015: 東京大学, 医学部循環器内科, 特任講師 2012 – 2014: 東京大学, 医学部附属病院, 助教 Less
Review Section/Research Field	Principal Investigator Medium-sized Section 53:Organ-based internal medicine and related fields / Basic Section 53020:Cardiology-related / Biological Sciences / Cardiovascular medicine / Circulatory organs internal medicine Except Principal Investigator Cardiovascular medicine / Basic Section 49010:Pathological biochemistry-related / Basic Section 53020:Cardiology-related / Biological Sciences / Basic Section 49020:Human pathology-related … More / Medium-sized Section 90:Biomedical engineering and related fields / Basic Section 42040:Laboratory animal science-related / Medium-sized Section 62:Applied informatics and related fields / Tumor biology Less
Keywords	Principal Investigator 心臓病 / 炎症 / リモデリング / 血管 / 心臓 / マクロファージ / 線維化 / 血管新生 / 低酸素シグナル / HIF-1α … More / VEGF / VEGF-A / 血管内皮細胞増殖因子 / がん / 組織線維化 / ワクチン / 心筋細胞 / VEGFA / 心不全 / 免疫 / 内科 / 温度生物学 / 温度 / 内科学 / 心臓リモデリング / 心血管リモデリング / 動脈硬化 / 血管リモデリング … More Except Principal Investigator マクロファージ / 炎症 / 心不全 / 温度 / マウス / 代謝 / 心臓線維化 / 心臓リモデリング / 内科 / 低酸素 / 循環器・高血圧 / 高血圧 / 性差医療 / VEGF / KRAS / 胃腸上皮型 / 肺腺癌 / 肺癌 / 胃腸上皮分化 / HNF4A / Non-TRU / neuroendocrine tumor / lung adenocarcinoma / non-TRU type / TTF-1 / HNF4α / 生活環境病 / 炎症終息経路 / 低温シグナル / STAT6 / 低温 / 量子生命科学 / 超偏極13C MRI / 分子イメージング / SI-PET / パラ水素誘起偏極 / 低栄養 / 虚血環境 / 心線維化 / 線維芽細胞 / リバースリモデリング / ReverseTAC / Reverse TAC / 心臓線維芽細胞 / 心肥大 / エコー画像 / 機械学習 / 医療用超音波診断システム / 医療用超音波診断 / 医療用超音波検査 / 右心室 / 肺高血圧 / pulmonary hypertension / heart failure / 2型糖尿病 / 12-LOX / 血圧変動 / 圧受容器 / 糖尿病 / 圧受容器機能 / 癌間質 / NFkB / WNT / 腫瘍間質 / 酸素生物学 / センサー / イメージング / 細胞シグナル / 活性酸素種 / 酸素 / 低酸素シグナル / ストレス / HIF / 低酸素センサー / 低酸素応答 / エネルギー / 線維化 / 心臓病 / 肝臓病 / 慢性腎臓病 / 生活習慣病 / 発現制御 / 概日リズム / 時間生物学 / 循環器疾患 Less

VEGFシグナルの性差に基づく女性特異的な高血圧の病態解明
- Principal Investigator
  
  石田純一
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  The University of Tokyo
温度制御されるマクロファージ代謝の分子実態の解明
- Principal Investigator
  
  杉本大樹
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Jichi Medical University
心臓線維化の病態解明と免疫応答を介する治療応用Principal Investigator
- Principal Investigator
  
  武田憲彦
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Fund for the Promotion of Joint International Research (International Collaborative Research)
- Review Section
  
  Medium-sized Section 53:Organ-based internal medicine and related fields
- Research Institution
  The University of Tokyo
低酸素シグナルを標的とした安全かつ効果的な心臓病治療法を開発するPrincipal Investigator
- Principal Investigator
  
  武田憲彦
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Jichi Medical University
Elucidation of mechanisms of carcinogenesis, metastasis, and metabolism based on histological characteristics of HNF4alpha-positive lung adenocarcinoma
- Principal Investigator
  
  松原大祐
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  University of Tsukuba
Molecular mechanism of cold induced anti-inflammation
- Principal Investigator
  
  SUGIMOTO Hiroki
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Jichi Medical University
Development of stable isotope PET-like imaging using room temperature and low field nuclear polarization.
- Principal Investigator
  
  Matsumoto Shingo
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 90:Biomedical engineering and related fields
- Research Institution
  Hokkaido University
The roles of macrophages in cardiac remodelingPrincipal Investigator
- Principal Investigator
  
  Takeda Norihiko
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Jichi Medical University
Analysis of the effects of cancer-bearing status on cardiac function and blood pressurePrincipal Investigator
- Principal Investigator
  
  Takeda Norihiko
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 53:Organ-based internal medicine and related fields
- Research Institution
  The University of Tokyo
  Jichi Medical University
Functional analysis of anti-fibrotic macrophage in the cardiac remodelling
- Principal Investigator
  
  Isagawa Takayuki
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Jichi Medical University
  Nagasaki University
Automated Evaluation of Cardiac Function with Data-Driven Medical Ultrasound System
- Principal Investigator
  
  Kotani Kiyoshi
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 62:Applied informatics and related fields
- Research Institution
  The University of Tokyo
New Experimental Model of Cardiac Function Recovery
- Principal Investigator
  
  SEMBA HIROAKI
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 42040:Laboratory animal science-related
- Research Institution
  The University of Tokyo
Effects of baroreflex receptor dysfunction on cardiomyocyte in diabetes mellitus
- Principal Investigator
  
  Sakamoto Masaya
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Jikei University School of Medicine
therapeutic strategy for right heart failure considerling energetic metabolism of cardiomyocytes
- Principal Investigator
  
  Maki Hisataka
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  The University of Tokyo
The roles of inflammatory signals in cardiovascular remodelingPrincipal Investigator
- Principal Investigator
  
  Takeda Norihiko
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  The University of Tokyo
温度が炎症細胞の代謝、機能に与える影響の解析Principal Investigator
- Principal Investigator
  
  武田憲彦
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Promotion of oxygen biology on the basis of international networks
- Principal Investigator
  
  Mori Yasuo
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
;The roles of hypoxia signaling in the pathogenesis of lifestyle related diseases
- Principal Investigator
  
  Nangaku Masaomi
- Project Period (FY)
  2014 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Sequencing-based analysis of tumor-stromal interactions
- Principal Investigator
  
  Isagawa Takayuki
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor biology
- Research Institution
  Tokyo Medical and Dental University
Disturbance of Circadian Rhythm in Heart Failure and Chronotherapeutic Approach to Heart Failure
- Principal Investigator
  
  MAEMURA Koji
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Nagasaki University
The roles of macrophage polarization in vascular remodelingPrincipal Investigator
- Principal Investigator
  
  TAKEDA NORIHIKO
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  The University of Tokyo

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 Other

All Journal Article Presentation

[Journal Article] The roles of HIF-1α signaling in cardiovascular diseases2023
- Author(s)
  Sato Tatsuyuki、Takeda Norihiko
- Journal Title
  
  Journal of Cardiology
  
  Volume: 81 Issue: 2 Pages: 202-208
- DOI
  10.1016/j.jjcc.2022.09.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08418, KAKENHI-PROJECT-20KK0196
[Journal Article] A data-driven analysis of myocardial tissue contraction on mild transverse aortic constriction2023
- Author(s)
  Kento Fujino, Tatsuyuki Sato, Yuanbo Wang, Masato Sugino, Norihiko Takeda, Yasuhiko Jimbo, Kiyoshi Kotani
- Journal Title
  
  IEEJ Transactions on electrical and eletronic engineering
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H04122
[Journal Article] Hyperpolarized <sup>13</sup>C Magnetic Resonance Imaging as a Tool for Imaging Tissue Redox State, Oxidative Stress, Inflammation, and Cellular Metabolism2022
- Author(s)
  Stewart Neil J.、Sato Tatsuyuki、Takeda Norihiko、Hirata Hiroshi、Matsumoto Shingo
- Journal Title
  
  Antioxidants & Redox Signaling
  
  Volume: 36 Issue: 1-3 Pages: 81-94
- DOI
  10.1089/ars.2021.0139
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H00654, KAKENHI-PROJECT-18H04122
[Journal Article] Establishment of Novel Protein Interaction Assays between Sin3 and REST Using Surface Plasmon Resonance and Time-Resolved Fluorescence Energy Transfer2021
- Author(s)
  Harada, M., Nagai, J., Kurata, R., Cui, X., Isagawa, T., Semba, H., ... & Yonezawa, T.
- Journal Title
  
  International journal of molecular sciences
  
  Volume: 22(5) Issue: 5 Pages: 2323-2323
- DOI
  10.3390/ijms22052323
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02360, KAKENHI-PROJECT-18K06895, KAKENHI-PROJECT-21K06566, KAKENHI-PROJECT-19K08542
[Journal Article] Osteoclasts adapt to physioxia perturbation through DNA demethylation2021
- Author(s)
  Nishikawa Keizo、Seno Shigeto、Yoshihara Toshitada、Narazaki Ayako、Sugiura Yuki、Shimizu Reito、Kikuta Junichi、Sakaguchi Reiko、Suzuki Norio、Takeda Norihiko、Semba Hiroaki、Yamamoto Masamichi、et al
- Journal Title
  
  EMBO reports
  
  Volume: 22 Issue: 12 Pages: 53035-53035
- DOI
  10.15252/embr.202153035
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K22513, KAKENHI-PLANNED-20H05901, KAKENHI-PROJECT-19H05657, KAKENHI-PROJECT-19H03561, KAKENHI-PROJECT-21H02716, KAKENHI-PROJECT-20K09474, KAKENHI-PROJECT-21K05272, KAKENHI-PROJECT-20K20394, KAKENHI-PROJECT-18H04122, KAKENHI-PROJECT-23K21372
[Journal Article] NK cells in hypoxic skin mediate a trade-off between wound healing and antibacterial defence2021
- Author(s)
  Sobecki Michal、Krzywinska Ewelina、Nagarajan Shunmugam、Audig? Annette、Hu?nh Khanh、Zacharjasz Julian、Debbache Julien、Kerdiles Yann、Gotthardt Dagmar、Takeda Norihiko、Fandrey Joachim、Sommer Lukas、Sexl Veronika、Stockmann Christian
- Journal Title
  
  Nature Communications
  
  Volume: 12 Issue: 1 Pages: 4700-4700
- DOI
  10.1038/s41467-021-25065-w
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H04122
[Journal Article] Febuxostat, a Xanthine Oxidase Inhibitor, Decreased Macrophage Matrix Metalloproteinase Expression in Hypoxia.2020
- Author(s)
  Wei S, Isagawa T, Eguchi M, Sato D, Tsukano H, Miyata K, Oike Y, Takeda N, Ikeda S, Kawano H, Maemura K.
- Journal Title
  
  Biomedicines.
  
  Volume: 8(11) Issue: 11 Pages: 470-470
- DOI
  10.3390/biomedicines8110470
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08560, KAKENHI-PROJECT-19K08542
[Journal Article] Hypoxia-inducible factor-1 alpha maintains mouse articular cartilage through suppression of NF-κB signaling2020
- Author(s)
  Okada Keita、Mori Daisuke、Makii Yuma、Nakamoto Hideki、Murahashi Yasutaka、Yano Fumiko、Chang Song Ho、Taniguchi Yuki、Kobayashi Hiroshi、Semba Hiroaki、Takeda Norihiko、Piao Wen、Hanaoka Kenjiro、Nagano Tetsuo、Tanaka Sakae、Saito Taku
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 5425-5425
- DOI
  10.1038/s41598-020-62463-4
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09568, KAKENHI-PROJECT-19K22677, KAKENHI-PUBLICLY-18H04609, KAKENHI-PUBLICLY-19H05414, KAKENHI-PROJECT-17H04310, KAKENHI-PROJECT-18H02360, KAKENHI-PROJECT-20K20473, KAKENHI-PROJECT-17K10956, KAKENHI-PROJECT-17K10996, KAKENHI-PROJECT-17K10998, KAKENHI-PROJECT-20K09452, KAKENHI-PROJECT-16H05099, KAKENHI-PROJECT-18K09017, KAKENHI-PROJECT-18K09055, KAKENHI-PROJECT-19K09641, KAKENHI-PROJECT-17K10955, KAKENHI-PROJECT-17K10997, KAKENHI-PROJECT-20K09405
[Journal Article] Cell cycle perturbation induces collagen production in fibroblasts.2019
- Author(s)
  Wake M, Takeda N, Isagawa T, Sato T, Nakagama Y, Morioka MS, Hirota Y, Asagiri M, Maemura K, Manabe I, Tanabe K, Komuro I.
- Journal Title
  
  Int Heart J.
  
  Volume: in press
- NAID
  130007684138
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-26111003
[Journal Article] Macrophage hypoxia signaling regulates cardiac fibrosis via Oncostatin M.2019
- Author(s)
  Abe H, Takeda N, Isagawa T, Semba H, Nishimura S, Morioka MS, Nakagama Y, Sato T, Soma K, Koyama K, Wake M, Katoh M, Asagiri M, Neugent ML, Kim JW, Stockmann C, Yonezawa T, Inuzuka R, Hirota Y, Maemura K, Yamashita T, Otsu K, Manabe I, Nagai R, Komuro I.
- Journal Title
  
  Nature Communications
  
  Volume: in press
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26111003
[Journal Article] Murine Model of Pulmonary Artery Overflow Vasculopathy Revealed Macrophage Accumulation in the Lung2019
- Author(s)
  Minatsuki Shun、Takeda Norihiko、Soma Katsura、Katoh Manami、Maki Hisataka、Hatano Masaru、Takimoto Eiki、Manabe Ichiro、Komuro Issei
- Journal Title
  
  Int. Heart J.
  
  Volume: 60 Issue: 2 Pages: 451-456
- DOI
  10.1536/ihj.18-281
- NAID
  130007617444
- ISSN
  1349-2365, 1349-3299
- Year and Date
  2019-03-30
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-26111003, KAKENHI-PROJECT-18K15880, KAKENHI-PROJECT-18K16413, KAKENHI-PROJECT-16K09493
[Journal Article] Seasonal Variations in the Achievement of Guideline Targets for HbA1c, Blood Pressure, and Cholesterol Among Patients With Type 2 Diabetes: A Nationwide Population-Based Study (ABC Study JDDM49)2019
- Author(s)
  Sakamoto Masaya、Matsutani Daisuke、Minato Soichiro、Tsujimoto Yuki、Kayama Yosuke、Takeda Norihiko、Ichikawa Seiichi、Horiuchi Ryuzo、Utsunomiya Kazunori、Nishikawa Masako
- Journal Title
  
  Diabetes Care
  
  Volume: 42 Issue: 5 Pages: 816-823
- DOI
  10.2337/dc18-1953
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-26111003
[Journal Article] Therapeutic targeting of mitochondrial ROS ameliorates murine model of volume overload cardiomyopathy.2019
- Author(s)
  Okamura K, Nakagama Y, Takeda N, Soma K, Sato T, Isagawa T, Kido Y, Sakamoto M, Manabe I, Hirata Y, Komuro I, Ono M
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 141 Issue: 1 Pages: 56-63
- DOI
  10.1016/j.jphs.2019.09.005
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08542, KAKENHI-PROJECT-18K15880, KAKENHI-PROJECT-19K23992, KAKENHI-PROJECT-18KK0454, KAKENHI-PROJECT-17K15679, KAKENHI-PROJECT-18H04122
[Journal Article] Cell cycle perturbation induces collagen production in fibroblasts.2019
- Author(s)
  Wake Masaki, Takeda Norihiko, Isagawa Takayuki, Sato Tatsuyuki, Nakagama Yu, Morioka Masaki, Hirota Yasushi, Asagiri Masataka, Maemura Koji, Manabe Ichiro, Tanabe Kazuaki and Komuro Issei.
- Journal Title
  
  International Heart Journal
  
  Volume: 印刷中
- NAID
  130007684138
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09493
[Journal Article] Establishment of novel cells stably secreting various human IL-18 recombinant proteins.2019
- Author(s)
  Asuka Kumagai, Kenji Shimizu, Riho Kurata, Xiaofeng Cui, Takayuki Isagawa, Msamitsu Harada, Jun Nagai, Yasuhiro Yoshida, Kei-ichi Ozaki, Norihiko Takeda, Hiroaki Semba and Tomo Yonezawa
- Journal Title
  
  Current Pharmaceutical Biotechnology
  
  Volume: 20 Issue: 1 Pages: 47-55
- DOI
  10.2174/1389201020666190206203640
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06895, KAKENHI-PROJECT-16K21229, KAKENHI-PLANNED-26111003, KAKENHI-PROJECT-18K06694, KAKENHI-PROJECT-18H02360
[Journal Article] Cell Cycle Perturbation Induces Collagen Production in Fibroblasts2019
- Author(s)
  Wake M, Takeda N, Isagawa T, Sato T, Nakagama Y, Morioka MS, Hirota Y, Asagiri M, Maemura K, Manabe I, Tanabe K, Komuro I.
- Journal Title
  
  Int. Heart J.
  
  Volume: 60 Issue: 4 Pages: 958-963
- DOI
  10.1536/ihj.18-710
- NAID
  130007684138
- ISSN
  1349-2365, 1349-3299
- Year and Date
  2019-07-30
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08542, KAKENHI-PROJECT-17K09592, KAKENHI-PROJECT-18K19601, KAKENHI-PROJECT-16H04679, KAKENHI-PROJECT-18H04122
[Journal Article] Macrophage hypoxia signaling regulates cardiac fibrosis via Oncostatin M.2019
- Author(s)
  Abe H, Takeda N, Isagawa T, Semba H, Nishimura S, Morioka MS, Nakagama Y, Sato T, Soma K, Koyama K, Wake M, Katoh M, Asagiri M, Neugent ML, Kim JW, Stockmann C, Yonezawa T, Inuzuka R, Hirota Y, Maemura K, Yamashita T, Otsu K, Manabe I, Nagai R, Komuro I.
- Journal Title
  
  Nature Communications
  
  Volume: 10 Issue: 1 Pages: 2824-2833
- DOI
  10.1038/s41467-019-10859-w
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08542, KAKENHI-PROJECT-18K15880, KAKENHI-PROJECT-17H01560, KAKENHI-PROJECT-18H02360, KAKENHI-PROJECT-17K09592, KAKENHI-PROJECT-18K19601, KAKENHI-PROJECT-16H04679, KAKENHI-PROJECT-18H04122, KAKENHI-PROJECT-19H03144
[Journal Article] Accelerated Cardiomyocyte Proliferation in the Heart of a Neonate With LEOPARD Syndrome-Associated Fatal Cardiomyopathy.2018
- Author(s)
  Nakagama Y, Inuzuka R, Ichimura K, Hinata M, Takehara H, Takeda N, Kakiuchi S, Shiraga K, Asakai H, Shindo T, Hirata Y, Saitoh M, Oka A.
- Journal Title
  
  Circulation: Heart Failure
  
  Volume: 11(4) Issue: 4
- DOI
  10.1161/circheartfailure.117.004660
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K10059, KAKENHI-PROJECT-17J09192, KAKENHI-PROJECT-16K09984, KAKENHI-PLANNED-26111003
[Journal Article] Visit-to-visit HbA1c variability is inversely related to baroreflex sensitivity independently of HbA1c value in type 2 diabetes2018
- Author(s)
  Matsutani Daisuke、Sakamoto Masaya、Minato Soichiro、Kayama Yosuke、Takeda Norihiko、Horiuchi Ryuzo、Utsunomiya Kazunori
- Journal Title
  
  Cardiovascular Diabetology
  
  Volume: 17 Issue: 1 Pages: 100-100
- DOI
  10.1186/s12933-018-0743-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-26111003
[Journal Article] Targeting HIF-1α/PDK1 Axis by Dichloroacetate (DCA) Suppresses Bleomycin-induced Pulmonary Fibrosis2018
- Author(s)
  Goodwin J, Choi H, Hsieh MH, Nuegent ML, Ahn JM, Hayenga HN, Singh PK, Shackelford DB, Lee IK, Shulaev V, Dhar S, Takeda N, Kim JW.
- Journal Title
  
  Am J Respir Cell Mol Biol
  
  Volume: 58 Issue: 2 Pages: 216-231
- DOI
  10.1165/rcmb.2016-0186oc
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26111003, KAKENHI-PROJECT-16K09493
[Journal Article] Necrostatin-7 suppresses RANK-NFATc1 signaling and attenuates macrophage to osteoclast differentiation2018
- Author(s)
  Fuji H、Ohmae S、Noma N、Takeiri M、Yasutomi H、Izumi K、Ito M、Toyomoto M、Iwaki S、Takemoto K、Seo S、Taura K、Hida S、Aoyama M、Ishihama Y、Hagiwara M、Takeda N、Hatano E、Iwaisako K、Uemoto S、Asagiri M
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 503 Issue: 2 Pages: 544-549
- DOI
  10.1016/j.bbrc.2018.05.153
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-26111003, KAKENHI-PROJECT-16K10101
[Journal Article] Pyruvate Dehydrogenase PDH-E1β Controls Tumor Progression by Altering the Metabolic Status of Cancer Cells.2018
- Author(s)
  Yonashiro R, Eguchi K, Wake M, Takeda N, Nakayama K.
- Journal Title
  
  Cancer Research
  
  Volume: 78 Issue: 7 Pages: 1592-1603
- DOI
  10.1158/0008-5472.can-17-1751
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-17H05523, KAKENHI-PLANNED-26111003, KAKENHI-PROJECT-15K08260, KAKENHI-PROJECT-18K07225
[Journal Article] Effect of canagliflozin on left ventricular diastolic function in patients with type 2 diabetes2018
- Author(s)
  Matsutani Daisuke、Sakamoto Masaya、Kayama Yosuke、Takeda Norihiko、Horiuchi Ryuzo、Utsunomiya Kazunori
- Journal Title
  
  Cardiovascular Diabetology
  
  Volume: 17 Issue: 1 Pages: 73-73
- DOI
  10.1186/s12933-018-0717-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-26111003, KAKENHI-PROJECT-16K09493
[Journal Article] HIF2α in the uterine stroma permits embryo invasion and luminal epithelium detachment2018
- Author(s)
  Matsumoto Leona、Hirota Yasushi、Saito-Fujita Tomoko、Takeda Norihiko、Tanaka Tomoki、Hiraoka Takehiro、Akaeda Shun、Fujita Hidetoshi、Shimizu-Hirota Ryoko、Igaue Shota、Matsuo Mitsunori、Haraguchi Hirofumi、Saito-Kanatani Mayuko、Fujii Tomoyuki、Osuga Yutaka
- Journal Title
  
  Journal of Clinical Investigation
  
  Volume: 128 Issue: 7 Pages: 3186-3197
- DOI
  10.1172/jci98931
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10668, KAKENHI-PROJECT-18K19600, KAKENHI-PROJECT-18K19601, KAKENHI-PLANNED-26111003, KAKENHI-PROJECT-17H06640, KAKENHI-PROJECT-17J05930, KAKENHI-PROJECT-18K09284, KAKENHI-PROJECT-17K16833, KAKENHI-PROJECT-16H06279, KAKENHI-PROJECT-16H04679, KAKENHI-PROJECT-16H05469, KAKENHI-PROJECT-16K09493
[Journal Article] Combined Surgical and Medical Therapy for <i>Candida</i> Prosthetic Endocarditis in a Patient with Repaired Tetralogy of Fallot2018
- Author(s)
  Kubota Kana、Soma Katsura、Uehara Masae、Inaba Toshiro、Saito Akihito、Takeda Norihiko、Hatano Masaru、Morita Hiroyuki、Inuzuka Ryo、Hirata Yasutaka、Yao Atsushi、Komuro Issei
- Journal Title
  
  Int. Heart J.
  
  Volume: 59 Issue: 4 Pages: 877-880
- DOI
  10.1536/ihj.17-314
- NAID
  130007427442
- ISSN
  1349-2365, 1349-3299
- Year and Date
  2018-07-31
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-26111003
[Journal Article] Glycemic variability in continuous glucose monitoring is inversely associated with baroreflex sensitivity in type 2 diabetes: a preliminary report2018
- Author(s)
  Matsutani Daisuke、Sakamoto Masaya、Iuchi Hiroyuki、Minato Souichirou、Suzuki Hirofumi、Kayama Yosuke、Takeda Norihiko、Horiuchi Ryuzo、Utsunomiya Kazunori
- Journal Title
  
  Cardiovasc Diabetol
  
  Volume: 17 Issue: 1 Pages: 36-36
- DOI
  10.1186/s12933-018-0683-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-26111003
[Journal Article] The Roles of Hypoxia Signaling in the Pathogenesis of Cardiovascular Diseases2017
- Author(s)
  Abe Hajime、Semba Hiroaki、Takeda Norihiko
- Journal Title
  
  Journal of Atherosclerosis and Thrombosis
  
  Volume: 24 Issue: 9 Pages: 884-894
- DOI
  10.5551/jat.RV17009
- NAID
  130006038428
- ISSN
  1340-3478, 1880-3873
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15990, KAKENHI-PLANNED-26111003
[Journal Article] Loss of HIF-1α in natural killer cells inhibits tumour growth by stimulating non-productive angiogenesis.2017
- Author(s)
  Krzywinska E, Kantari-Mimoun C, Kerdiles Y, Sobecki M, Isagawa T, Gotthardt D, Castells M, Haubold J, Millien C, Viel T, Tavitian B, Takeda N, Fandrey J, Vivier E, Sexl V, Stockmann C.
- Journal Title
  
  Nat Commun
  
  Volume: 8 Issue: 1 Pages: 1597-1597
- DOI
  10.1038/s41467-017-01599-w
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09592, KAKENHI-INTERNATIONAL-15K21759, KAKENHI-PLANNED-26111003
[Journal Article] Distinct Metabolic Phenotypes within Non-small Cell 1 Lung Cancer Define Selective Vulnerability to Glycolytic Inhibition of Lung Squamous Cell Carcinoma.2017
- Author(s)
  Goodwin J, Neugent ML, Lee SY, Choe JH, Choi H, Jenkins DMR, Ruthenborg RJ, Robinson MW, Jeong JY, Wake M, Abe H, Takeda N, Endo H, Inoue M, Xuan Z, Yoo H, Chen M, Ahn JM, Minna JD, Helke KL, Singh PK, Shackelford DB, Kim JW.
- Journal Title
  
  Nat Commun
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26111003
[Journal Article] The distinct metabolic phenotype of lung squamous cell carcinoma defines selective vulnerability to glycolytic inhibition.2017
- Author(s)
  Goodwin J, Neugent ML, Lee SY, Choe JH, Choi H, Jenkins DMR, Ruthenborg RJ, Robinson MW, Jeong JY, Wake M, Abe H, Takeda N, Endo H, Inoue M, Xuan Z, Yoo H, Chen M, Ahn JM, Minna JD, Helke KL, Singh PK, Shackelford DB, Kim JW.
- Journal Title
  
  Nature Communications
  
  Volume: 8 Issue: 1 Pages: 15503-15503
- DOI
  10.1038/ncomms15503
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10414, KAKENHI-INTERNATIONAL-15K21759, KAKENHI-PLANNED-26111003, KAKENHI-PLANNED-26111005
[Journal Article] Planimetry of the orifice area in aortic valve stenosis using phase-contrast cardiac magnetic resonance imaging.2017
- Author(s)
  Abe H., Iguchi N, Utanohara Y, Takada K, Hen Y, Machida H, Takeda N, Sumiyoshi T.
- Journal Title
  
  Int Heart J
  
  Volume: 印刷中
- NAID
  130006321387
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-26111003
[Journal Article] Actin-binding protein coronin 1A controls osteoclastic bone resorption by regulating lysosomal secretion of cathepsin K2017
- Author(s)
  Ohmae S, Noma N, Toyomoto M, Shinohara M, Takeiri M, Fuji H, Takemoto K, Iwaisako K, Fujita T, Takeda N, Kawatani M, Aoyama M, Hagiwara M, Ishihama Y, Asagiri M
- Journal Title
  
  Sci Rep
  
  Volume: - Issue: 1 Pages: 41710-41710
- DOI
  10.1038/srep41710
- NAID
  120006313626
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-16H01634, KAKENHI-PLANNED-26111003, KAKENHI-PROJECT-14J06672, KAKENHI-PROJECT-26461909, KAKENHI-PROJECT-16K01941, KAKENHI-PROJECT-16K10101, KAKENHI-PROJECT-15K15540
[Journal Article] Bevacizumab-related microvascular angina and its management with nicorandil.2017
- Author(s)
  Katoh M, Takeda N, Arimoto T, Abe H, Oda K, Osuga Y, Fujii T, Komuro I.
- Journal Title
  
  Int Heart J
  
  Volume: 印刷中
- NAID
  130006179206
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-26111003
[Journal Article] Time-dependent effects of ipragliflozin on behaviour and energy homeostasis in normal and type 2 diabetic rats: continuous glucose telemetry analysis.2017
- Author(s)
  Iuchi H, Sakamoto M, Matsutani D, Suzuki H, Kayama Y, Takeda N, Minamisawa S, Utsunomiya K.
- Journal Title
  
  Sci Rep
  
  Volume: 22 Issue: 1 Pages: 351-354
- DOI
  10.1038/s41598-017-12106-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09277, KAKENHI-PROJECT-16K15184, KAKENHI-PLANNED-26111003, KAKENHI-PROJECT-17H01529
[Journal Article] Mitochondrial Abnormality Facilitates Cyst Formation in Autosomal Dominant Polycystic Kidney Disease2017
- Author(s)
  Ishimoto Y, Inagi R, Yoshihara D, Kugita M, Nagao S, Shimizu A, Takeda N, Wake M, Honda K, Zhou J, Nangaku M
- Journal Title
  
  Mol Cell Biol
  
  Volume: e-Pub Issue: 24
- DOI
  10.1128/mcb.00337-17
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26111003, KAKENHI-PROJECT-15K08435, KAKENHI-PROJECT-15K09247, KAKENHI-PROJECT-15KT0088, KAKENHI-PROJECT-16K15465
[Journal Article] Cardiac Sarcoidosis Diagnosed by Incidental Lymph Node Biopsy2017
- Author(s)
  Matsuda J, Fujiu K, Roh S, Tajima M, Maki H, Kojima T, Ushiku T, Nawata K, Takeda N,　Watanabe M, Akazawa H, Komuro I.
- Journal Title
  
  Int. Heart J.
  
  Volume: 58 Issue: 1 Pages: 140-143
- DOI
  10.1536/ihj.16-218
- NAID
  130005330527
- ISSN
  1349-2365, 1349-3299
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26111003, KAKENHI-PROJECT-16K09510
[Journal Article] Association between day-by-day and ambulatory blood pressure variability in type 2 diabetes patients2017
- Author(s)
  Iuchi H, Sakamoto M, Matsutani D, Suzuki H, Kayama Y, Takeda N, Utsunomiya K
- Journal Title
  
  Blood Press Monit
  
  Volume: 22 Issue: 6 Pages: 351-354
- DOI
  10.1097/mbp.0000000000000285
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-26111003
[Journal Article] Circadian clock and the onset of cardiovascular events.2016
- Author(s)
  Takeda N, Maemura K.
- Journal Title
  
  Hypertens Res.
  
  Volume: in press Issue: 6 Pages: 383-90
- DOI
  10.1038/hr.2016.9
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-26111003, KAKENHI-PROJECT-25461113
[Journal Article] HIF-1α-PDK1 axis induced active glycolysis plays an essential role in macrophage migratory capacity.2016
- Author(s)
  2)Semba H, Takeda N, Isagawa T, Sugiura Y, Honda K, Wake M, Miyazawa H, Yamaguchi Y, Miura M, Jenkins D, Choi H, Kim JW, Asagiri M, Cowburn AS, Abe H, Soma K, Koyama K, Katoh M, Sayama K, Goda N, Johnson RS, Manabe I, Nagai R, Komuro I.
- Journal Title
  
  Nat commun
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461113
[Journal Article] Redox-sensitive transient receptor potential channels in oxygen sensing and adaptation.2016
- Author(s)
  Mori Y, Takahashi N, Polat OK, Kuroakwa T, Takeda N, Inoue M
- Journal Title
  
  Pflugers Arch. Eur. J. Physiol.
  
  Volume: 468 Issue: 1 Pages: 85-97
- DOI
  10.1007/s00424-015-1716-2
- NAID
  120005980858
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-INTERNATIONAL-15K21759, KAKENHI-ORGANIZER-26111001, KAKENHI-PLANNED-26111003, KAKENHI-PLANNED-26111004, KAKENHI-PLANNED-26111005, KAKENHI-PROJECT-25461113, KAKENHI-PROJECT-26840032
[Journal Article] HIF-1α-PDK1 axis induced active glycolysis plays an essential role in macrophage migratory capacity.2016
- Author(s)
  Semba H, Takeda N, Isagawa T, Sugiura Y, Honda K, Wake M, Miyazawa H, Yamaguchi Y, Miura M, Jenkins D, Choi H, Kim JW, Asagiri M, Cowburn AS, Abe H, Soma K, Koyama K, Katoh M, Sayama K, Goda N, Johnson RS, Manabe I, Nagai R, Komuro I.
- Journal Title
  
  Nat commun.
  
  Volume: in press
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-26111003
[Journal Article] HIF-1alpha-PDK1 axis-induced active glycolysis plays an essential role in macrophage migratory capacity2016
- Author(s)
  Semba, H., Takeda, N., Isagawa, T., Sugiura, Y., Honda, K., Wake, M., Miyazawa, H., Yamaguchi, Y., Miura, M., Jenkins, DM., Choi, H., Kim, JW., Asagiri, M., Cowburn, AS., Abe, H., Soma, K., Koyama, K., Katoh, M., Sayama, K., Goda, N., Johnson, RS., Manabe, I., Nagai, R., Komuro, I.
- Journal Title
  
  Nature Communications
  
  Volume: 7 Issue: 1 Pages: 11635-11635
- DOI
  10.1038/ncomms11635
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26110005, KAKENHI-PLANNED-26111003, KAKENHI-PROJECT-26253049, KAKENHI-PROJECT-15H04824, KAKENHI-PROJECT-16H06145, KAKENHI-PROJECT-15K19369, KAKENHI-PROJECT-15K19372
[Journal Article] Cardiogenic syncope possibly related to bevacizumab-containing combination chemotherapy for advanced non-small cell lung cancer.2016
- Author(s)
  Chino H, Amano Y, Yamauchi Y, Matsuda J, Takeda N, Tanaka G, Takai D, Nagase T.
- Journal Title
  
  J Thorac Dis
  
  Volume: 8 Pages: 2646-2650
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-26111003
[Journal Article] The role of clock genes and circadian rhythm in the development of cardiovascular diseases.2015
- Author(s)
  Takeda N, Maemura K.
- Journal Title
  
  Cell Mol Life Sci
  
  Volume: 72 Issue: 17 Pages: 3225-3234
- DOI
  10.1007/s00018-015-1923-1
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-26111003, KAKENHI-PROJECT-25461113
[Journal Article] Hypoxia Signaling Cascade for Erythropoietin Production in Hepatocytes.2015
- Author(s)
  Tojo Y, Sekine H, Hirano I, Pan X, Souma T, Tsujita T, Kawaguchi S, Takeda N, Takeda K, Fong GH, Dan T, Ichinose M, Miyata T, Yamamoto M, Suzuki N.
- Journal Title
  
  Mol Cell Biol.
  
  Volume: 35 Issue: 15 Pages: 2658-2672
- DOI
  10.1128/mcb.00161-15
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860623, KAKENHI-PROJECT-26860625, KAKENHI-PLANNED-26111002, KAKENHI-PLANNED-26111003, KAKENHI-PUBLICLY-26116702, KAKENHI-PROJECT-15H04691, KAKENHI-PROJECT-25461113, KAKENHI-PROJECT-25670157
[Journal Article] Necrostatin-1 protects against reactive oxygen species (ROS)-induced hepatotoxicity in acetaminophen-induced acute liver failure.2014
- Author(s)
  Takemoto K, Hatano E, Iwaisako K, Takeiri M, Noma N, Ohmae S, Toriguchi K, Tanabe K, Tanaka H, Seo S, Taura K, Machida K, Takeda N, Saji S, Uemoto S, Asagiri M.
- Journal Title
  
  FEBS Open Bio
  
  Volume: 4 Issue: 1 Pages: 777-787
- DOI
  10.1016/j.fob.2014.08.007
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-14J06672, KAKENHI-PROJECT-24659822, KAKENHI-PROJECT-24689056, KAKENHI-PLANNED-26111003, KAKENHI-PROJECT-26461909
[Journal Article] Non-invasive diagnosis of coronary artery disease by 123I-BMIPP/201TlCl dual myocardial SPECT in patients with heart failure2014
- Author(s)
  Abe H, Iguchi N, Utanohara Y, Inoue K, Takamisawa I, Seki A, Tanizaki K, Takeda N, Tohbaru T, Asano R, Nagayama M, Takayama M, Umemura J, Sumiyoshi T, Tomoike H.
- Journal Title
  
  Int J Cardiol
  
  Volume: 176 Issue: 3 Pages: 969-974
- DOI
  10.1016/j.ijcard.2014.08.129
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461113, KAKENHI-PLANNED-26111003
[Journal Article] Regulation of wound healing and fibrosis by hypoxia and hypoxia-inducible factor-1.2014
- Author(s)
  Ruthenborg RJ, Ban JJ, Wazir A, Takeda N, Kim JW.
- Journal Title
  
  Mol Cells
  
  Volume: 37 Issue: 9 Pages: 637-643
- DOI
  10.14348/molcells.2014.0150
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-26111003
[Journal Article] Angiotensin II impairs endothelial nitric-oxide synthase bioavailability under free cholesterol-enriched conditions via intracellular free cholesterol-rich membrane microdomains2013
- Author(s)
  Amiya E, Watanabe M, Takeda N, Saito T, Shiga T, Hosoya Y, Nakao T, Imai Y, Manabe I, Nagai R, Komuro I, Maemura K.
- Journal Title
  
  J Biol Chem
  
  Volume: 288 Issue: 20 Pages: 14497-509
- DOI
  10.1074/jbc.m112.448522
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790837, KAKENHI-PROJECT-25461113
[Journal Article] 2. VEGF-A induces its negative regulator, soluble form of VEGFR-1, by modulating its alternative splicing.2013
- Author(s)
  Saito T, Takeda N, Amiya E, Nakao T, Abe H, Semba H, Soma K, Koyama K, Hosoya Y, Imai Y, Isagawa T, Watanabe M, Manabe I, Komuro I, Nagai R, Maemura K.
- Journal Title
  
  FEBS Lett.
  
  Volume: 587 Pages: 2179-2185
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591109
[Journal Article] Vegf-a induces its negative regulator, soluble form of vegfr-1, by modulating its alternative splicing.2013
- Author(s)
  Saito T, Takeda N, Amiya E, Nakao T, Abe H, Semba H, Soma K, Koyama K, Hosoya Y, Imai Y, Isagawa T, Watanabe M, Manabe I, Komuro I, Nagai R, Maemura K.
- Journal Title
  
  FEBS letters
  
  Volume: 587 Issue: 14 Pages: 2179-2185
- DOI
  10.1016/j.febslet.2013.05.038
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461113
[Journal Article] Circadian expressions of cardiac ion channel genes in mouse might be associated with the central clock in the SCN but not the peripheral clock in the heart.2013
- Author(s)
  Tong M, Watanabe E, Yamamoto N, Nagahata-Ishiguro M, Maemura K, Takeda N, Nagai R, Ozaki Y.
- Journal Title
  
  Biol Rhythm Res
  
  Volume: 44 Issue: 4 Pages: 519-530
- DOI
  10.1080/09291016.2012.704801
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461113
[Journal Article] 1. HIF isoforms in the skin differentially regulate systemic arterial pressure.2013
- Author(s)
  Cowburn AS, Takeda N, Boutin AT, Kim JW, Sterling JC, Nakasaki M, Southwood M, Goldrath AW, Jamora C, Nizet V, Chilvers ER, Johnson RS.
- Journal Title
  
  Proc Natl Acad Sci U S A
  
  Volume: 110 Pages: 17570-17575
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591109
[Presentation] 酸素シグナルと心血管リモデリング2022
- Author(s)
  武田憲彦
- Organizer
  第86回日本循環器学会学術集会シンポジウム
- Data Source
  KAKENHI-PROJECT-18H04122
[Presentation] 組織リモデリングにおける低酸素シグナル2019
- Author(s)
  武田憲彦
- Organizer
  第92回日本薬理学会年会
- Invited
- Data Source
  KAKENHI-PLANNED-26111003
[Presentation] Roles of Ly6Chi macrophages hypoxia signaling in cardiac fibrosis2019
- Author(s)
  Norihiko Takeda
- Organizer
  Keystone Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26111003
[Presentation] 低酸素シグナルを介する心臓リモデリング2018
- Author(s)
  武田憲彦
- Organizer
  第47回日本心脈管作動物質学会
- Invited
- Data Source
  KAKENHI-PLANNED-26111003
[Presentation] The roles of lactate metabolism in cardiac function2018
- Author(s)
  武田憲彦
- Organizer
  第82回日本循環器学会学術集会
- Invited
- Data Source
  KAKENHI-PLANNED-26111003
[Presentation] Genomewide analysis of HIF-1α target genes in macrophage adaptation for the microenvironment2018
- Author(s)
  Isagawa T, Takeda N,　Semba H, Morioka M, Maemura K.
- Organizer
  第1回日本循環器学会基礎研究フォーラム
- Data Source
  KAKENHI-PLANNED-26111003
[Presentation] The roles of glucose and lactate metabolism in the regulation of mitochondrial respiration2018
- Author(s)
  武田憲彦
- Organizer
  第6回低酸素研究会・酸素生物学領域国際シンポジウム
- Invited
- Data Source
  KAKENHI-PLANNED-26111003
[Presentation] The roles of glucose and lactate metabolism in the regulation of mitochondrial respiration2018
- Author(s)
  Norihiko Takeda
- Organizer
  Hypoxia Research Meeting
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26111003
[Presentation] マクロファージ微小環境適応における転写制御機構2018
- Author(s)
  砂河孝行, 武田憲彦, 仙波宏章，安部元, 相馬桂, 和氣正樹, 加藤愛巳, 森岡勝樹, 魏碩俣, 前村浩二
- Organizer
  第47回日本心脈管作動物質学会
- Data Source
  KAKENHI-PLANNED-26111003
[Presentation] The roles of hypoxia or inflammatory signals in cardiovascular remodeling2017
- Author(s)
  Takeda N.
- Organizer
  Special Research Seminar at 神戸女子薬科大学
- Invited
- Data Source
  KAKENHI-PLANNED-26111003
[Presentation] 低酸素誘導性肺血管リモデリングにおける炎症細胞の役割2017
- Author(s)
  武田憲彦
- Organizer
  第9回日本生理学会大会
- Place of Presentation
  アクトシティ浜松、静岡
- Year and Date
  2017-03-30
- Invited
- Data Source
  KAKENHI-PLANNED-26111003
[Presentation] Flt-1 in M1 macrophages promotes immature vascular formation2017
- Author(s)
  Soma K, Takeda N, Isagawa T, Abe H, Semba H, Koyama K, Wake M, Kato M, Nakagama Y, Manabe I, Nagai R, Komuro I
- Organizer
  European society of cardiology, ESC congress 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26111003
[Presentation] HIF-1alpha-PDK1 axis induced active glycolysis plays an essential role in macrophage migratory capacity.2017
- Author(s)
  Takeda N.
- Organizer
  Keystone Symposium “Adaptaions to Hypoxia in Physiology and Disease”
- Place of Presentation
  Whistler Conference Centre, Whistler, British Columbia, Canada
- Year and Date
  2017-03-09
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26111003
[Presentation] The Role of Eosinophils in Pulmonary Arterial Remodelling2017
- Author(s)
  武田憲彦
- Organizer
  第81回日本循環器学会学術集会
- Place of Presentation
  ホテル日航金沢、金沢
- Year and Date
  2017-03-17
- Invited
- Data Source
  KAKENHI-PLANNED-26111003
[Presentation] The roles of lactate metabolism in cardiac function2017
- Author(s)
  Takeda N.
- Organizer
  Consortium of Biological Sciences 2017
- Invited
- Data Source
  KAKENHI-PLANNED-26111003
[Presentation] High-Throughput shRNA Screening of the Molecular Mechanisms in Cardiac Fibroblast Activation2017
- Author(s)
  Koyama K, Takeda N, Abe H, Semba H, Soma K, Wake M, Katoh M, Nakagama Y, Isagawa T, Komuro I
- Organizer
  European society of cardiology, ESC congress 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26111003
[Presentation] Switching of two HIF-alpha; isforms regulates inflammatory processes and cardiac remodeling2016
- Author(s)
  武田憲彦
- Organizer
  第52回高血圧関連疾患モデル学会
- Place of Presentation
  秋葉原UDX、東京
- Year and Date
  2016-09-22
- Invited
- Data Source
  KAKENHI-PLANNED-26111003
[Presentation] HIF-1α - PDK1 axis induced active glycolysis plays an essential role in macrophage migratory capacity2016
- Author(s)
  Takeda N, Semba H, Isagawa T, Abe H, Sugiura Y, Honda K, Wake M, Kim JW, Soma K, Koyama K, Katoh M, Johnson RS, Manabe I, Nagai R, Komuro I
- Organizer
  Keystone symposium; Immunometabolism in immune function and inflammatory disease
- Place of Presentation
  Alberta, Canada
- Year and Date
  2016-02-24
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26111003
[Presentation] HIF-1alpha-PDK1 axis induced active glycolysis plays an essential role in macrophage migratory capacity.2016
- Author(s)
  Takeda N.
- Organizer
  2016 HDRC International Symposium
- Place of Presentation
  Incheon, Korea
- Year and Date
  2016-06-17
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26111003
[Presentation] Roles of Ly6Chi monocytes hypoxia signaling in cardiac remodeling2016
- Author(s)
  Abe H, Takeda N, Semba H, Soma K, Koyama K, Wake M, Katoh M, Manabe I, Nagai R, Komuro I
- Organizer
  Keystone symposium; Immunometabolism in immune function and inflammatory disease
- Place of Presentation
  Alberta, Canada
- Year and Date
  2016-02-22
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26111003
[Presentation] HIF-1alpha-PDK1経路を介した代謝リプログラミングはマクロファージ遊走能を促進する2016
- Author(s)
  武田憲彦
- Organizer
  第37回日本肥満学会
- Place of Presentation
  東京ファッションタウン、東京
- Year and Date
  2016-10-08
- Invited
- Data Source
  KAKENHI-PLANNED-26111003
[Presentation] Perivascular accumulation of M1 macrophages elicits the development of immature vascular formation.2016
- Author(s)
  武田憲彦
- Organizer
  第24回日本血管生物医学会学術集会
- Place of Presentation
  長崎ブリックホール、長崎
- Year and Date
  2016-12-10
- Invited
- Data Source
  KAKENHI-PLANNED-26111003
[Presentation] マクロファージ活性化における細胞内グルコース代謝の役割2016
- Author(s)
  武田憲彦
- Organizer
  第20回日本適応医学会学術集会
- Place of Presentation
  東京コンベンションホール、東京
- Year and Date
  2016-12-16
- Invited
- Data Source
  KAKENHI-PLANNED-26111003
[Presentation] HIF-1α - Pdk1 axis induced metabolic reprogramming critically regulates macrophage function in inflammatory conditions2016
- Author(s)
  Semba H, Takeda N, Isagawa T, Wake M, Abe H, Soma K, Koyama K, Katoh M, Manabe I, Nagai R, Takeshi Yamashita, Komuro I
- Organizer
  第80回日本循環器学会総会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Year and Date
  2016-03-18
- Data Source
  KAKENHI-PLANNED-26111003
[Presentation] 心血管リモデリングにおける炎症細胞・低酸素シグナルの役割2016
- Author(s)
  武田憲彦
- Organizer
  第48回日本動脈硬化学会総会学術集会
- Place of Presentation
  京王プラザホテル、東京
- Year and Date
  2016-07-14
- Invited
- Data Source
  KAKENHI-PLANNED-26111003
[Presentation] HIF-1αを介する解糖系代謝シフトはマクロファージ遊走能を促進する2015
- Author(s)
  武田憲彦
- Organizer
  第19回酸素ダイナミクス研究会
- Place of Presentation
  東京女子医科大学健保会館（東京都新宿区）
- Year and Date
  2015-09-12
- Data Source
  KAKENHI-PLANNED-26111003
[Presentation] Hypoxia induced metabolic reprograming in macrophages.2015
- Author(s)
  Takeda N.
- Organizer
  An International Symposium on Oxygen Biology
- Place of Presentation
  早稲田大学先端生命医科学センター/TWIns（東京都新宿区）
- Year and Date
  2015-07-24
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26111003
[Presentation] 低酸素シグナルを介する心血管病態治療の可能性2015
- Author(s)
  武田憲彦
- Organizer
  第47回日本動脈硬化学会総会学術集会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Year and Date
  2015-07-09
- Invited
- Data Source
  KAKENHI-PLANNED-26111003
[Presentation] 低酸素シグナルを介する心血管病態治療の可能性2015
- Author(s)
  武田憲彦
- Organizer
  第47回日本動脈硬化学会総会学術集会
- Place of Presentation
  仙台国際センター(仙台市）
- Year and Date
  2015-07-09
- Invited
- Data Source
  KAKENHI-PROJECT-25461113
[Presentation] HIF-1α-PDK1を介する解糖系代謝シフトがマクロファージ遊走能を促進する2015
- Author(s)
  武田憲彦
- Organizer
  第38回日本分子生物学会年会・第88回日本生化学会大会合同大会
- Place of Presentation
  神戸国際会議場（神戸市）
- Year and Date
  2015-12-01
- Invited
- Data Source
  KAKENHI-PROJECT-25461113
[Presentation] 炎症プロセスにおけるマクロファージ細胞内代謝調節機構の役割2015
- Author(s)
  武田憲彦
- Organizer
  脳心血管抗加齢研究会2015
- Place of Presentation
  大阪梅田スカイビル（大阪府大阪市）
- Year and Date
  2015-11-25
- Invited
- Data Source
  KAKENHI-PLANNED-26111003
[Presentation] M1マクロファージの集積遷延は腫瘍内血管の未熟化を引き起こす2015
- Author(s)
  相馬桂　武田憲彦　砂河孝行　安部元　仙波宏章　小山雄広　和氣正樹　加藤愛巳　真鍋一郎　永井良三　小室一成
- Organizer
  第23回日本血管生物医学会学術集会
- Place of Presentation
  神戸国際会議場（兵庫県神戸市）
- Year and Date
  2015-12-12
- Data Source
  KAKENHI-PLANNED-26111003
[Presentation] Roles of Macrophages Hypoxia Signaling in Pressure Overload Induced Cardiac Remodeling2015
- Author(s)
  Abe H, Takeda N, Semba H, Soma K, Koyama K, Wake M, Manabe I, Nagai R, Komuro I.
- Organizer
  第79回日本循環器学会学術集会
- Place of Presentation
  大阪
- Year and Date
  2015-04-24
- Data Source
  KAKENHI-PLANNED-26111003
[Presentation] Roles of macrophages hypoxia signaling in pressure overload-induced cardiac remodeling2015
- Author(s)
  Abe H, Takeda N, Semba H, Soma K, Koyama K, Wake M, Katoh M, Manabe I, Nagai R, Komuro I
- Organizer
  第32回国際心臓研究学会日本部会
- Place of Presentation
  神戸国際会議場（兵庫県神戸市）
- Year and Date
  2015-12-10
- Data Source
  KAKENHI-PLANNED-26111003
[Presentation] Perivascular accumulation of M1 macrophages elicits the development of immature vascular formation.2015
- Author(s)
  Soma K, Takeda N, Isagawa T, Abe H, Semba H, Koyama K, Wake M, Manabe I, Nagai R, Komuro I
- Organizer
  ESC Congress2015
- Place of Presentation
  London, UK
- Year and Date
  2015-09-01
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26111003
[Presentation] HIF-1α;-PDK1を介する解糖系代謝シフトがマクロファージ遊走能を促進する2015
- Author(s)
  武田憲彦
- Organizer
  第３８回日本分子生物学会年会・第８８回日本生化学会大会合同大会
- Place of Presentation
  神戸国際会議場（兵庫県神戸市）
- Year and Date
  2015-12-04
- Invited
- Data Source
  KAKENHI-PLANNED-26111003
[Presentation] マクロファージの代謝リプログラミングにおける細胞内低酸素センサー2014
- Author(s)
  仙波宏章, 武田憲彦, 砂河孝行, 杉浦悠毅, 安部元, 相馬桂, 小山雄広, 和氣正樹, 真鍋一郎, 小室一成, 永井良三
- Organizer
  第37回日本分子生物学会年会ワークショップ
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-11-26
- Data Source
  KAKENHI-PLANNED-26111003
[Presentation] マクロファージの代謝リプログラミングにおける細胞内低酸素センサー2014
- Author(s)
  仙波宏章、武田憲彦、砂河孝行、杉浦悠毅、安部元、相馬桂、小山雄広、和氣正樹、真鍋一郎、永井良三、小室一成
- Organizer
  第37回日本分子生物学会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-11-26
- Data Source
  KAKENHI-PROJECT-24591109
[Presentation] Roles of macrophage hypoxia signaling in cardiac remodeling2013
- Author(s)
  Hajime Abe, Norihiko Takeda, Hiroaki Semba, Katsura Soma, Takayuki Isagawa, Ichiro Manabe, Ryozo Nagai, Issei Komuro
- Organizer
  Keystone Symposium 2013
- Place of Presentation
  Keystone, 米国
- Data Source
  KAKENHI-PROJECT-24591109
[Presentation] 生活習慣病、心血管リモデリングにおける低酸素ストレスの役割2013
- Author(s)
  武田憲彦
- Organizer
  日本肥満学会
- Place of Presentation
  東京（東京国際フォーラム）
- Invited
- Data Source
  KAKENHI-PROJECT-24591109
[Presentation] Hypoxic responses of M1 macrophages are critical for the regulation of cardiac fibrosis2012
- Author(s)
  Hajime Abe, Norihiko Takeda, Hiroaki Semba, Katsura Soma, Takayuki Isagawa, Ichiro Manabe, Ryozo Nagai, Issei Komuro
- Organizer
  AHA Scientific Session 2012
- Place of Presentation
  Los Angeles, 米国
- Data Source
  KAKENHI-PROJECT-24591109
[Presentation] Transcriptional Regulation：Role of Clock Genes and Circadian Rhythm in the Development of Cardiovascular Diseases
- Author(s)
  Koji Maemura, Norihiko Takeda, Tomoko Nakao, Hiroyuki Morita, Hiroaki Kawano
- Organizer
  The 18th International Vascular Biology Meeting
- Place of Presentation
  京都みやこメッセ（京都市）
- Year and Date
  2014-04-14 – 2014-04-17
- Invited
- Data Source
  KAKENHI-PROJECT-25461113

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# of Collaborated Projects: 4 results

# of Collaborated Products: 3 results
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10. Matsumoto Shingo (90741041)

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28. SUMIMOTO hideki

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35. YAMAGUCHI Yoshifumi

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36. UTSUNOMIYA Kazunori

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46. 相馬友和

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Takeda Norihiko 武田 憲彦

TAKEDA NORIHIKO 武田 憲彦

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心臓線維化の病態解明と免疫応答を介する治療応用Principal Investigator

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低酸素シグナルを標的とした安全かつ効果的な心臓病治療法を開発するPrincipal Investigator

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The roles of macrophages in cardiac remodelingPrincipal Investigator

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Analysis of the effects of cancer-bearing status on cardiac function and blood pressurePrincipal Investigator

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The roles of inflammatory signals in cardiovascular remodelingPrincipal Investigator

Takeda Norihiko 武田憲彦

TAKEDA NORIHIKO 武田憲彦