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Takeda Norihiko  武田 憲彦

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… Alternative Names

TAKEDA NORIHIKO  武田 憲彦

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Researcher Number 40422307
Other IDs
Affiliation (Current) 2025: 東京大学, 医学部附属病院, 教授
2025: 自治医科大学, 医学部, 非常勤講師
Affiliation (based on the past Project Information) *help 2023 – 2024: 東京大学, 医学部附属病院, 教授
2023 – 2024: 自治医科大学, 医学部, 非常勤講師
2020 – 2023: 自治医科大学, 医学部, 教授
2017 – 2019: 東京大学, 医学部附属病院, 助教
2014 – 2018: 東京大学, 医学部附属病院, 特任講師 … More
2015: 東京大学, 医学部附属病院, 講師
2015: 東京大学, 医学部循環器内科, 特任講師
2012 – 2014: 東京大学, 医学部附属病院, 助教 Less
Review Section/Research Field
Principal Investigator
Medium-sized Section 53:Organ-based internal medicine and related fields / Basic Section 53020:Cardiology-related / Biological Sciences / Cardiovascular medicine / Circulatory organs internal medicine
Except Principal Investigator
Cardiovascular medicine / Basic Section 49010:Pathological biochemistry-related / Biological Sciences / Basic Section 49020:Human pathology-related / Medium-sized Section 90:Biomedical engineering and related fields … More / Basic Section 53020:Cardiology-related / Basic Section 42040:Laboratory animal science-related / Medium-sized Section 62:Applied informatics and related fields / Tumor biology Less
Keywords
Principal Investigator
心臓病 / 炎症 / リモデリング / 血管 / 心臓 / マクロファージ / 線維化 / 血管新生 / 低酸素シグナル / HIF-1α … More / VEGF / VEGF-A / 血管内皮細胞増殖因子 / がん / 組織線維化 / ワクチン / 心筋細胞 / VEGFA / 心不全 / 免疫 / 内科 / 温度生物学 / 温度 / 内科学 / 心臓リモデリング / 心血管リモデリング / 動脈硬化 / 血管リモデリング … More
Except Principal Investigator
マクロファージ / 炎症 / 心不全 / 温度 / マウス / 代謝 / 心臓線維化 / 心臓リモデリング / 内科 / 低酸素 / 循環器・高血圧 / 高血圧 / KRAS / 胃腸上皮型 / 肺腺癌 / 肺癌 / 胃腸上皮分化 / HNF4A / Non-TRU / neuroendocrine tumor / lung adenocarcinoma / non-TRU type / TTF-1 / HNF4α / 生活環境病 / 炎症終息経路 / 低温シグナル / STAT6 / 低温 / 量子生命科学 / 超偏極13C MRI / 分子イメージング / SI-PET / パラ水素誘起偏極 / 低栄養 / 虚血環境 / 心線維化 / 線維芽細胞 / リバースリモデリング / ReverseTAC / Reverse TAC / 心臓線維芽細胞 / 心肥大 / エコー画像 / 機械学習 / 医療用超音波診断システム / 医療用超音波診断 / 医療用超音波検査 / 右心室 / 肺高血圧 / pulmonary hypertension / heart failure / 2型糖尿病 / 12-LOX / 血圧変動 / 圧受容器 / 糖尿病 / 圧受容器機能 / 癌間質 / NFkB / WNT / 腫瘍間質 / 酸素生物学 / センサー / イメージング / 細胞シグナル / 活性酸素種 / 酸素 / 低酸素シグナル / ストレス / HIF / 低酸素センサー / 低酸素応答 / エネルギー / 線維化 / 心臓病 / 肝臓病 / 慢性腎臓病 / 生活習慣病 / 発現制御 / 概日リズム / 時間生物学 / 循環器疾患 Less
  • Research Projects

    (20 results)
  • Research Products

    (95 results)
  • Co-Researchers

    (47 People)
  •  温度制御されるマクロファージ代謝の分子実態の解明

    • Principal Investigator
      杉本 大樹
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 49010:Pathological biochemistry-related
    • Research Institution
      Jichi Medical University
  •  心臓線維化の病態解明と免疫応答を介する治療応用Principal Investigator

    • Principal Investigator
      武田 憲彦
    • Project Period (FY)
      2024 – 2027
    • Research Category
      Fund for the Promotion of Joint International Research (International Collaborative Research)
    • Review Section
      Medium-sized Section 53:Organ-based internal medicine and related fields
    • Research Institution
      The University of Tokyo
  •  低酸素シグナルを標的とした安全かつ効果的な心臓病治療法を開発するPrincipal Investigator

    • Principal Investigator
      武田 憲彦
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53020:Cardiology-related
    • Research Institution
      Jichi Medical University
  •  Elucidation of mechanisms of carcinogenesis, metastasis, and metabolism based on histological characteristics of HNF4alpha-positive lung adenocarcinoma

    • Principal Investigator
      松原 大祐
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 49020:Human pathology-related
    • Research Institution
      University of Tsukuba
  •  Molecular mechanism of cold induced anti-inflammation

    • Principal Investigator
      SUGIMOTO Hiroki
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 49010:Pathological biochemistry-related
    • Research Institution
      Jichi Medical University
  •  Development of stable isotope PET-like imaging using room temperature and low field nuclear polarization.

    • Principal Investigator
      Matsumoto Shingo
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Review Section
      Medium-sized Section 90:Biomedical engineering and related fields
    • Research Institution
      Hokkaido University
  •  The roles of macrophages in cardiac remodelingPrincipal Investigator

    • Principal Investigator
      Takeda Norihiko
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53020:Cardiology-related
    • Research Institution
      Jichi Medical University
  •  Analysis of the effects of cancer-bearing status on cardiac function and blood pressurePrincipal Investigator

    • Principal Investigator
      Takeda Norihiko
    • Project Period (FY)
      2020 – 2023
    • Research Category
      Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
    • Review Section
      Medium-sized Section 53:Organ-based internal medicine and related fields
    • Research Institution
      The University of Tokyo
      Jichi Medical University
  •  Functional analysis of anti-fibrotic macrophage in the cardiac remodelling

    • Principal Investigator
      Isagawa Takayuki
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53020:Cardiology-related
    • Research Institution
      Jichi Medical University
      Nagasaki University
  •  Automated Evaluation of Cardiac Function with Data-Driven Medical Ultrasound System

    • Principal Investigator
      Kotani Kiyoshi
    • Project Period (FY)
      2018 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Review Section
      Medium-sized Section 62:Applied informatics and related fields
    • Research Institution
      The University of Tokyo
  •  New Experimental Model of Cardiac Function Recovery

    • Principal Investigator
      SEMBA HIROAKI
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 42040:Laboratory animal science-related
    • Research Institution
      The University of Tokyo
  •  Effects of baroreflex receptor dysfunction on cardiomyocyte in diabetes mellitus

    • Principal Investigator
      Sakamoto Masaya
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cardiovascular medicine
    • Research Institution
      Jikei University School of Medicine
  •  therapeutic strategy for right heart failure considerling energetic metabolism of cardiomyocytes

    • Principal Investigator
      Maki Hisataka
    • Project Period (FY)
      2016 – 2017
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Cardiovascular medicine
    • Research Institution
      The University of Tokyo
  •  The roles of inflammatory signals in cardiovascular remodelingPrincipal Investigator

    • Principal Investigator
      Takeda Norihiko
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cardiovascular medicine
    • Research Institution
      The University of Tokyo
  •  温度が炎症細胞の代謝、機能に与える影響の解析Principal Investigator

    • Principal Investigator
      武田 憲彦
    • Project Period (FY)
      2016 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo
  •  Promotion of oxygen biology on the basis of international networks

    • Principal Investigator
      Mori Yasuo
    • Project Period (FY)
      2015 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      Kyoto University
  •  ;The roles of hypoxia signaling in the pathogenesis of lifestyle related diseases

    • Principal Investigator
      Nangaku Masaomi
    • Project Period (FY)
      2014 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo
  •  Sequencing-based analysis of tumor-stromal interactions

    • Principal Investigator
      Isagawa Takayuki
    • Project Period (FY)
      2014 – 2015
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Tumor biology
    • Research Institution
      Tokyo Medical and Dental University
  •  Disturbance of Circadian Rhythm in Heart Failure and Chronotherapeutic Approach to Heart Failure

    • Principal Investigator
      MAEMURA Koji
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cardiovascular medicine
    • Research Institution
      Nagasaki University
  •  The roles of macrophage polarization in vascular remodelingPrincipal Investigator

    • Principal Investigator
      TAKEDA NORIHIKO
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      The University of Tokyo

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 Other

All Journal Article Presentation

  • [Journal Article] The roles of HIF-1α signaling in cardiovascular diseases2023

    • Author(s)
      Sato Tatsuyuki、Takeda Norihiko
    • Journal Title

      Journal of Cardiology

      Volume: 81 Issue: 2 Pages: 202-208

    • DOI

      10.1016/j.jjcc.2022.09.002

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K08418, KAKENHI-PROJECT-20KK0196
  • [Journal Article] A data-driven analysis of myocardial tissue contraction on mild transverse aortic constriction2023

    • Author(s)
      Kento Fujino, Tatsuyuki Sato, Yuanbo Wang, Masato Sugino, Norihiko Takeda, Yasuhiko Jimbo, Kiyoshi Kotani
    • Journal Title

      IEEJ Transactions on electrical and eletronic engineering

      Volume: -

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18H04122
  • [Journal Article] Hyperpolarized <sup>13</sup>C Magnetic Resonance Imaging as a Tool for Imaging Tissue Redox State, Oxidative Stress, Inflammation, and Cellular Metabolism2022

    • Author(s)
      Stewart Neil J.、Sato Tatsuyuki、Takeda Norihiko、Hirata Hiroshi、Matsumoto Shingo
    • Journal Title

      Antioxidants &amp; Redox Signaling

      Volume: 36 Issue: 1-3 Pages: 81-94

    • DOI

      10.1089/ars.2021.0139

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20H00654, KAKENHI-PROJECT-18H04122
  • [Journal Article] Establishment of Novel Protein Interaction Assays between Sin3 and REST Using Surface Plasmon Resonance and Time-Resolved Fluorescence Energy Transfer2021

    • Author(s)
      Harada, M., Nagai, J., Kurata, R., Cui, X., Isagawa, T., Semba, H., ... & Yonezawa, T.
    • Journal Title

      International journal of molecular sciences

      Volume: 22(5) Issue: 5 Pages: 2323-2323

    • DOI

      10.3390/ijms22052323

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H02360, KAKENHI-PROJECT-18K06895, KAKENHI-PROJECT-21K06566, KAKENHI-PROJECT-19K08542
  • [Journal Article] Osteoclasts adapt to physioxia perturbation through DNA demethylation2021

    • Author(s)
      Nishikawa Keizo、Seno Shigeto、Yoshihara Toshitada、Narazaki Ayako、Sugiura Yuki、Shimizu Reito、Kikuta Junichi、Sakaguchi Reiko、Suzuki Norio、Takeda Norihiko、Semba Hiroaki、Yamamoto Masamichi、et al
    • Journal Title

      EMBO reports

      Volume: 22 Issue: 12 Pages: 53035-53035

    • DOI

      10.15252/embr.202153035

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K22513, KAKENHI-PLANNED-20H05901, KAKENHI-PROJECT-19H05657, KAKENHI-PROJECT-19H03561, KAKENHI-PROJECT-21H02716, KAKENHI-PROJECT-20K09474, KAKENHI-PROJECT-21K05272, KAKENHI-PROJECT-20K20394, KAKENHI-PROJECT-18H04122, KAKENHI-PROJECT-23K21372
  • [Journal Article] NK cells in hypoxic skin mediate a trade-off between wound healing and antibacterial defence2021

    • Author(s)
      Sobecki Michal、Krzywinska Ewelina、Nagarajan Shunmugam、Audig? Annette、Hu?nh Khanh、Zacharjasz Julian、Debbache Julien、Kerdiles Yann、Gotthardt Dagmar、Takeda Norihiko、Fandrey Joachim、Sommer Lukas、Sexl Veronika、Stockmann Christian
    • Journal Title

      Nature Communications

      Volume: 12 Issue: 1 Pages: 4700-4700

    • DOI

      10.1038/s41467-021-25065-w

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H04122
  • [Journal Article] Febuxostat, a Xanthine Oxidase Inhibitor, Decreased Macrophage Matrix Metalloproteinase Expression in Hypoxia.2020

    • Author(s)
      Wei S, Isagawa T, Eguchi M, Sato D, Tsukano H, Miyata K, Oike Y, Takeda N, Ikeda S, Kawano H, Maemura K.
    • Journal Title

      Biomedicines.

      Volume: 8(11) Issue: 11 Pages: 470-470

    • DOI

      10.3390/biomedicines8110470

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K08560, KAKENHI-PROJECT-19K08542
  • [Journal Article] Hypoxia-inducible factor-1 alpha maintains mouse articular cartilage through suppression of NF-κB signaling2020

    • Author(s)
      Okada Keita、Mori Daisuke、Makii Yuma、Nakamoto Hideki、Murahashi Yasutaka、Yano Fumiko、Chang Song Ho、Taniguchi Yuki、Kobayashi Hiroshi、Semba Hiroaki、Takeda Norihiko、Piao Wen、Hanaoka Kenjiro、Nagano Tetsuo、Tanaka Sakae、Saito Taku
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 5425-5425

    • DOI

      10.1038/s41598-020-62463-4

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K09568, KAKENHI-PROJECT-19K22677, KAKENHI-PUBLICLY-18H04609, KAKENHI-PUBLICLY-19H05414, KAKENHI-PROJECT-17H04310, KAKENHI-PROJECT-18H02360, KAKENHI-PROJECT-20K20473, KAKENHI-PROJECT-17K10956, KAKENHI-PROJECT-17K10996, KAKENHI-PROJECT-17K10998, KAKENHI-PROJECT-20K09452, KAKENHI-PROJECT-16H05099, KAKENHI-PROJECT-18K09017, KAKENHI-PROJECT-18K09055, KAKENHI-PROJECT-19K09641, KAKENHI-PROJECT-17K10955, KAKENHI-PROJECT-17K10997, KAKENHI-PROJECT-20K09405
  • [Journal Article] Cell cycle perturbation induces collagen production in fibroblasts.2019

    • Author(s)
      Wake M, Takeda N, Isagawa T, Sato T, Nakagama Y, Morioka MS, Hirota Y, Asagiri M, Maemura K, Manabe I, Tanabe K, Komuro I.
    • Journal Title

      Int Heart J.

      Volume: in press

    • NAID

      130007684138

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-26111003
  • [Journal Article] Macrophage hypoxia signaling regulates cardiac fibrosis via Oncostatin M.2019

    • Author(s)
      Abe H, Takeda N, Isagawa T, Semba H, Nishimura S, Morioka MS, Nakagama Y, Sato T, Soma K, Koyama K, Wake M, Katoh M, Asagiri M, Neugent ML, Kim JW, Stockmann C, Yonezawa T, Inuzuka R, Hirota Y, Maemura K, Yamashita T, Otsu K, Manabe I, Nagai R, Komuro I.
    • Journal Title

      Nature Communications

      Volume: in press

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-26111003
  • [Journal Article] Murine Model of Pulmonary Artery Overflow Vasculopathy Revealed Macrophage Accumulation in the Lung2019

    • Author(s)
      Minatsuki Shun、Takeda Norihiko、Soma Katsura、Katoh Manami、Maki Hisataka、Hatano Masaru、Takimoto Eiki、Manabe Ichiro、Komuro Issei
    • Journal Title

      Int. Heart J.

      Volume: 60 Issue: 2 Pages: 451-456

    • DOI

      10.1536/ihj.18-281

    • NAID

      130007617444

    • ISSN
      1349-2365, 1349-3299
    • Year and Date
      2019-03-30
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-26111003, KAKENHI-PROJECT-18K15880, KAKENHI-PROJECT-18K16413, KAKENHI-PROJECT-16K09493
  • [Journal Article] Seasonal Variations in the Achievement of Guideline Targets for HbA1c, Blood Pressure, and Cholesterol Among Patients With Type 2 Diabetes: A Nationwide Population-Based Study (ABC Study JDDM49)2019

    • Author(s)
      Sakamoto Masaya、Matsutani Daisuke、Minato Soichiro、Tsujimoto Yuki、Kayama Yosuke、Takeda Norihiko、Ichikawa Seiichi、Horiuchi Ryuzo、Utsunomiya Kazunori、Nishikawa Masako
    • Journal Title

      Diabetes Care

      Volume: 42 Issue: 5 Pages: 816-823

    • DOI

      10.2337/dc18-1953

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-26111003
  • [Journal Article] Therapeutic targeting of mitochondrial ROS ameliorates murine model of volume overload cardiomyopathy.2019

    • Author(s)
      Okamura K, Nakagama Y, Takeda N, Soma K, Sato T, Isagawa T, Kido Y, Sakamoto M, Manabe I, Hirata Y, Komuro I, Ono M
    • Journal Title

      Journal of Pharmacological Sciences

      Volume: 141 Issue: 1 Pages: 56-63

    • DOI

      10.1016/j.jphs.2019.09.005

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K08542, KAKENHI-PROJECT-18K15880, KAKENHI-PROJECT-19K23992, KAKENHI-PROJECT-18KK0454, KAKENHI-PROJECT-17K15679, KAKENHI-PROJECT-18H04122
  • [Journal Article] Cell cycle perturbation induces collagen production in fibroblasts.2019

    • Author(s)
      Wake Masaki, Takeda Norihiko, Isagawa Takayuki, Sato Tatsuyuki, Nakagama Yu, Morioka Masaki, Hirota Yasushi, Asagiri Masataka, Maemura Koji, Manabe Ichiro, Tanabe Kazuaki and Komuro Issei.
    • Journal Title

      International Heart Journal

      Volume: 印刷中

    • NAID

      130007684138

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K09493
  • [Journal Article] Establishment of novel cells stably secreting various human IL-18 recombinant proteins.2019

    • Author(s)
      Asuka Kumagai, Kenji Shimizu, Riho Kurata, Xiaofeng Cui, Takayuki Isagawa, Msamitsu Harada, Jun Nagai, Yasuhiro Yoshida, Kei-ichi Ozaki, Norihiko Takeda, Hiroaki Semba and Tomo Yonezawa
    • Journal Title

      Current Pharmaceutical Biotechnology

      Volume: 20 Issue: 1 Pages: 47-55

    • DOI

      10.2174/1389201020666190206203640

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K06895, KAKENHI-PROJECT-16K21229, KAKENHI-PLANNED-26111003, KAKENHI-PROJECT-18K06694, KAKENHI-PROJECT-18H02360
  • [Journal Article] Cell Cycle Perturbation Induces Collagen Production in Fibroblasts2019

    • Author(s)
      Wake M, Takeda N, Isagawa T, Sato T, Nakagama Y, Morioka MS, Hirota Y, Asagiri M, Maemura K, Manabe I, Tanabe K, Komuro I.
    • Journal Title

      Int. Heart J.

      Volume: 60 Issue: 4 Pages: 958-963

    • DOI

      10.1536/ihj.18-710

    • NAID

      130007684138

    • ISSN
      1349-2365, 1349-3299
    • Year and Date
      2019-07-30
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K08542, KAKENHI-PROJECT-17K09592, KAKENHI-PROJECT-18K19601, KAKENHI-PROJECT-16H04679, KAKENHI-PROJECT-18H04122
  • [Journal Article] Macrophage hypoxia signaling regulates cardiac fibrosis via Oncostatin M.2019

    • Author(s)
      Abe H, Takeda N, Isagawa T, Semba H, Nishimura S, Morioka MS, Nakagama Y, Sato T, Soma K, Koyama K, Wake M, Katoh M, Asagiri M, Neugent ML, Kim JW, Stockmann C, Yonezawa T, Inuzuka R, Hirota Y, Maemura K, Yamashita T, Otsu K, Manabe I, Nagai R, Komuro I.
    • Journal Title

      Nature Communications

      Volume: 10 Issue: 1 Pages: 2824-2833

    • DOI

      10.1038/s41467-019-10859-w

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K08542, KAKENHI-PROJECT-18K15880, KAKENHI-PROJECT-17H01560, KAKENHI-PROJECT-18H02360, KAKENHI-PROJECT-17K09592, KAKENHI-PROJECT-18K19601, KAKENHI-PROJECT-16H04679, KAKENHI-PROJECT-18H04122, KAKENHI-PROJECT-19H03144
  • [Journal Article] Accelerated Cardiomyocyte Proliferation in the Heart of a Neonate With LEOPARD Syndrome-Associated Fatal Cardiomyopathy.2018

    • Author(s)
      Nakagama Y, Inuzuka R, Ichimura K, Hinata M, Takehara H, Takeda N, Kakiuchi S, Shiraga K, Asakai H, Shindo T, Hirata Y, Saitoh M, Oka A.
    • Journal Title

      Circulation: Heart Failure

      Volume: 11(4) Issue: 4

    • DOI

      10.1161/circheartfailure.117.004660

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K10059, KAKENHI-PROJECT-17J09192, KAKENHI-PROJECT-16K09984, KAKENHI-PLANNED-26111003
  • [Journal Article] Visit-to-visit HbA1c variability is inversely related to baroreflex sensitivity independently of HbA1c value in type 2 diabetes2018

    • Author(s)
      Matsutani Daisuke、Sakamoto Masaya、Minato Soichiro、Kayama Yosuke、Takeda Norihiko、Horiuchi Ryuzo、Utsunomiya Kazunori
    • Journal Title

      Cardiovascular Diabetology

      Volume: 17 Issue: 1 Pages: 100-100

    • DOI

      10.1186/s12933-018-0743-7

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-26111003
  • [Journal Article] Targeting HIF-1α/PDK1 Axis by Dichloroacetate (DCA) Suppresses Bleomycin-induced Pulmonary Fibrosis2018

    • Author(s)
      Goodwin J, Choi H, Hsieh MH, Nuegent ML, Ahn JM, Hayenga HN, Singh PK, Shackelford DB, Lee IK, Shulaev V, Dhar S, Takeda N, Kim JW.
    • Journal Title

      Am J Respir Cell Mol Biol

      Volume: 58 Issue: 2 Pages: 216-231

    • DOI

      10.1165/rcmb.2016-0186oc

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-26111003, KAKENHI-PROJECT-16K09493
  • [Journal Article] Necrostatin-7 suppresses RANK-NFATc1 signaling and attenuates macrophage to osteoclast differentiation2018

    • Author(s)
      Fuji H、Ohmae S、Noma N、Takeiri M、Yasutomi H、Izumi K、Ito M、Toyomoto M、Iwaki S、Takemoto K、Seo S、Taura K、Hida S、Aoyama M、Ishihama Y、Hagiwara M、Takeda N、Hatano E、Iwaisako K、Uemoto S、Asagiri M
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 503 Issue: 2 Pages: 544-549

    • DOI

      10.1016/j.bbrc.2018.05.153

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-26111003, KAKENHI-PROJECT-16K10101
  • [Journal Article] Pyruvate Dehydrogenase PDH-E1β Controls Tumor Progression by Altering the Metabolic Status of Cancer Cells.2018

    • Author(s)
      Yonashiro R, Eguchi K, Wake M, Takeda N, Nakayama K.
    • Journal Title

      Cancer Research

      Volume: 78 Issue: 7 Pages: 1592-1603

    • DOI

      10.1158/0008-5472.can-17-1751

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PUBLICLY-17H05523, KAKENHI-PLANNED-26111003, KAKENHI-PROJECT-15K08260, KAKENHI-PROJECT-18K07225
  • [Journal Article] Effect of canagliflozin on left ventricular diastolic function in patients with type 2 diabetes2018

    • Author(s)
      Matsutani Daisuke、Sakamoto Masaya、Kayama Yosuke、Takeda Norihiko、Horiuchi Ryuzo、Utsunomiya Kazunori
    • Journal Title

      Cardiovascular Diabetology

      Volume: 17 Issue: 1 Pages: 73-73

    • DOI

      10.1186/s12933-018-0717-9

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-26111003, KAKENHI-PROJECT-16K09493
  • [Journal Article] HIF2α in the uterine stroma permits embryo invasion and luminal epithelium detachment2018

    • Author(s)
      Matsumoto Leona、Hirota Yasushi、Saito-Fujita Tomoko、Takeda Norihiko、Tanaka Tomoki、Hiraoka Takehiro、Akaeda Shun、Fujita Hidetoshi、Shimizu-Hirota Ryoko、Igaue Shota、Matsuo Mitsunori、Haraguchi Hirofumi、Saito-Kanatani Mayuko、Fujii Tomoyuki、Osuga Yutaka
    • Journal Title

      Journal of Clinical Investigation

      Volume: 128 Issue: 7 Pages: 3186-3197

    • DOI

      10.1172/jci98931

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K10668, KAKENHI-PROJECT-18K19600, KAKENHI-PROJECT-18K19601, KAKENHI-PLANNED-26111003, KAKENHI-PROJECT-17H06640, KAKENHI-PROJECT-17J05930, KAKENHI-PROJECT-18K09284, KAKENHI-PROJECT-17K16833, KAKENHI-PROJECT-16H06279, KAKENHI-PROJECT-16H04679, KAKENHI-PROJECT-16H05469, KAKENHI-PROJECT-16K09493
  • [Journal Article] Combined Surgical and Medical Therapy for <i>Candida</i> Prosthetic Endocarditis in a Patient with Repaired Tetralogy of Fallot2018

    • Author(s)
      Kubota Kana、Soma Katsura、Uehara Masae、Inaba Toshiro、Saito Akihito、Takeda Norihiko、Hatano Masaru、Morita Hiroyuki、Inuzuka Ryo、Hirata Yasutaka、Yao Atsushi、Komuro Issei
    • Journal Title

      Int. Heart J.

      Volume: 59 Issue: 4 Pages: 877-880

    • DOI

      10.1536/ihj.17-314

    • NAID

      130007427442

    • ISSN
      1349-2365, 1349-3299
    • Year and Date
      2018-07-31
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-26111003
  • [Journal Article] Glycemic variability in continuous glucose monitoring is inversely associated with baroreflex sensitivity in type 2 diabetes: a preliminary report2018

    • Author(s)
      Matsutani Daisuke、Sakamoto Masaya、Iuchi Hiroyuki、Minato Souichirou、Suzuki Hirofumi、Kayama Yosuke、Takeda Norihiko、Horiuchi Ryuzo、Utsunomiya Kazunori
    • Journal Title

      Cardiovasc Diabetol

      Volume: 17 Issue: 1 Pages: 36-36

    • DOI

      10.1186/s12933-018-0683-2

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-26111003
  • [Journal Article] The Roles of Hypoxia Signaling in the Pathogenesis of Cardiovascular Diseases2017

    • Author(s)
      Abe Hajime、Semba Hiroaki、Takeda Norihiko
    • Journal Title

      Journal of Atherosclerosis and Thrombosis

      Volume: 24 Issue: 9 Pages: 884-894

    • DOI

      10.5551/jat.RV17009

    • NAID

      130006038428

    • ISSN
      1340-3478, 1880-3873
    • Language
      English
    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K15990, KAKENHI-PLANNED-26111003
  • [Journal Article] Loss of HIF-1α in natural killer cells inhibits tumour growth by stimulating non-productive angiogenesis.2017

    • Author(s)
      Krzywinska E, Kantari-Mimoun C, Kerdiles Y, Sobecki M, Isagawa T, Gotthardt D, Castells M, Haubold J, Millien C, Viel T, Tavitian B, Takeda N, Fandrey J, Vivier E, Sexl V, Stockmann C.
    • Journal Title

      Nat Commun

      Volume: 8 Issue: 1 Pages: 1597-1597

    • DOI

      10.1038/s41467-017-01599-w

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K09592, KAKENHI-INTERNATIONAL-15K21759, KAKENHI-PLANNED-26111003
  • [Journal Article] Distinct Metabolic Phenotypes within Non-small Cell 1 Lung Cancer Define Selective Vulnerability to Glycolytic Inhibition of Lung Squamous Cell Carcinoma.2017

    • Author(s)
      Goodwin J, Neugent ML, Lee SY, Choe JH, Choi H, Jenkins DMR, Ruthenborg RJ, Robinson MW, Jeong JY, Wake M, Abe H, Takeda N, Endo H, Inoue M, Xuan Z, Yoo H, Chen M, Ahn JM, Minna JD, Helke KL, Singh PK, Shackelford DB, Kim JW.
    • Journal Title

      Nat Commun

      Volume: 印刷中

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-26111003
  • [Journal Article] The distinct metabolic phenotype of lung squamous cell carcinoma defines selective vulnerability to glycolytic inhibition.2017

    • Author(s)
      Goodwin J, Neugent ML, Lee SY, Choe JH, Choi H, Jenkins DMR, Ruthenborg RJ, Robinson MW, Jeong JY, Wake M, Abe H, Takeda N, Endo H, Inoue M, Xuan Z, Yoo H, Chen M, Ahn JM, Minna JD, Helke KL, Singh PK, Shackelford DB, Kim JW.
    • Journal Title

      Nature Communications

      Volume: 8 Issue: 1 Pages: 15503-15503

    • DOI

      10.1038/ncomms15503

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K10414, KAKENHI-INTERNATIONAL-15K21759, KAKENHI-PLANNED-26111003, KAKENHI-PLANNED-26111005
  • [Journal Article] Planimetry of the orifice area in aortic valve stenosis using phase-contrast cardiac magnetic resonance imaging.2017

    • Author(s)
      Abe H., Iguchi N, Utanohara Y, Takada K, Hen Y, Machida H, Takeda N, Sumiyoshi T.
    • Journal Title

      Int Heart J

      Volume: 印刷中

    • NAID

      130006321387

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-26111003
  • [Journal Article] Actin-binding protein coronin 1A controls osteoclastic bone resorption by regulating lysosomal secretion of cathepsin K2017

    • Author(s)
      Ohmae S, Noma N, Toyomoto M, Shinohara M, Takeiri M, Fuji H, Takemoto K, Iwaisako K, Fujita T, Takeda N, Kawatani M, Aoyama M, Hagiwara M, Ishihama Y, Asagiri M
    • Journal Title

      Sci Rep

      Volume: - Issue: 1 Pages: 41710-41710

    • DOI

      10.1038/srep41710

    • NAID

      120006313626

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PUBLICLY-16H01634, KAKENHI-PLANNED-26111003, KAKENHI-PROJECT-14J06672, KAKENHI-PROJECT-26461909, KAKENHI-PROJECT-16K01941, KAKENHI-PROJECT-16K10101, KAKENHI-PROJECT-15K15540
  • [Journal Article] Bevacizumab-related microvascular angina and its management with nicorandil.2017

    • Author(s)
      Katoh M, Takeda N, Arimoto T, Abe H, Oda K, Osuga Y, Fujii T, Komuro I.
    • Journal Title

      Int Heart J

      Volume: 印刷中

    • NAID

      130006179206

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-26111003
  • [Journal Article] Time-dependent effects of ipragliflozin on behaviour and energy homeostasis in normal and type 2 diabetic rats: continuous glucose telemetry analysis.2017

    • Author(s)
      Iuchi H, Sakamoto M, Matsutani D, Suzuki H, Kayama Y, Takeda N, Minamisawa S, Utsunomiya K.
    • Journal Title

      Sci Rep

      Volume: 22 Issue: 1 Pages: 351-354

    • DOI

      10.1038/s41598-017-12106-y

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K09277, KAKENHI-PROJECT-16K15184, KAKENHI-PLANNED-26111003, KAKENHI-PROJECT-17H01529
  • [Journal Article] Mitochondrial Abnormality Facilitates Cyst Formation in Autosomal Dominant Polycystic Kidney Disease2017

    • Author(s)
      Ishimoto Y, Inagi R, Yoshihara D, Kugita M, Nagao S, Shimizu A, Takeda N, Wake M, Honda K, Zhou J, Nangaku M
    • Journal Title

      Mol Cell Biol

      Volume: e-Pub Issue: 24

    • DOI

      10.1128/mcb.00337-17

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-26111003, KAKENHI-PROJECT-15K08435, KAKENHI-PROJECT-15K09247, KAKENHI-PROJECT-15KT0088, KAKENHI-PROJECT-16K15465
  • [Journal Article] Cardiac Sarcoidosis Diagnosed by Incidental Lymph Node Biopsy2017

    • Author(s)
      Matsuda J, Fujiu K, Roh S, Tajima M, Maki H, Kojima T, Ushiku T, Nawata K, Takeda N, Watanabe M, Akazawa H, Komuro I.
    • Journal Title

      Int. Heart J.

      Volume: 58 Issue: 1 Pages: 140-143

    • DOI

      10.1536/ihj.16-218

    • NAID

      130005330527

    • ISSN
      1349-2365, 1349-3299
    • Language
      English
    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-26111003, KAKENHI-PROJECT-16K09510
  • [Journal Article] Association between day-by-day and ambulatory blood pressure variability in type 2 diabetes patients2017

    • Author(s)
      Iuchi H, Sakamoto M, Matsutani D, Suzuki H, Kayama Y, Takeda N, Utsunomiya K
    • Journal Title

      Blood Press Monit

      Volume: 22 Issue: 6 Pages: 351-354

    • DOI

      10.1097/mbp.0000000000000285

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-26111003
  • [Journal Article] Circadian clock and the onset of cardiovascular events.2016

    • Author(s)
      Takeda N, Maemura K.
    • Journal Title

      Hypertens Res.

      Volume: in press Issue: 6 Pages: 383-90

    • DOI

      10.1038/hr.2016.9

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-26111003, KAKENHI-PROJECT-25461113
  • [Journal Article] HIF-1α-PDK1 axis induced active glycolysis plays an essential role in macrophage migratory capacity.2016

    • Author(s)
      2)Semba H, Takeda N, Isagawa T, Sugiura Y, Honda K, Wake M, Miyazawa H, Yamaguchi Y, Miura M, Jenkins D, Choi H, Kim JW, Asagiri M, Cowburn AS, Abe H, Soma K, Koyama K, Katoh M, Sayama K, Goda N, Johnson RS, Manabe I, Nagai R, Komuro I.
    • Journal Title

      Nat commun

      Volume: 印刷中

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25461113
  • [Journal Article] Redox-sensitive transient receptor potential channels in oxygen sensing and adaptation.2016

    • Author(s)
      Mori Y, Takahashi N, Polat OK, Kuroakwa T, Takeda N, Inoue M
    • Journal Title

      Pflugers Arch. Eur. J. Physiol.

      Volume: 468 Issue: 1 Pages: 85-97

    • DOI

      10.1007/s00424-015-1716-2

    • NAID

      120005980858

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-INTERNATIONAL-15K21759, KAKENHI-ORGANIZER-26111001, KAKENHI-PLANNED-26111003, KAKENHI-PLANNED-26111004, KAKENHI-PLANNED-26111005, KAKENHI-PROJECT-25461113, KAKENHI-PROJECT-26840032
  • [Journal Article] HIF-1α-PDK1 axis induced active glycolysis plays an essential role in macrophage migratory capacity.2016

    • Author(s)
      Semba H, Takeda N, Isagawa T, Sugiura Y, Honda K, Wake M, Miyazawa H, Yamaguchi Y, Miura M, Jenkins D, Choi H, Kim JW, Asagiri M, Cowburn AS, Abe H, Soma K, Koyama K, Katoh M, Sayama K, Goda N, Johnson RS, Manabe I, Nagai R, Komuro I.
    • Journal Title

      Nat commun.

      Volume: in press

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PLANNED-26111003
  • [Journal Article] HIF-1alpha-PDK1 axis-induced active glycolysis plays an essential role in macrophage migratory capacity2016

    • Author(s)
      Semba, H., Takeda, N., Isagawa, T., Sugiura, Y., Honda, K., Wake, M., Miyazawa, H., Yamaguchi, Y., Miura, M., Jenkins, DM., Choi, H., Kim, JW., Asagiri, M., Cowburn, AS., Abe, H., Soma, K., Koyama, K., Katoh, M., Sayama, K., Goda, N., Johnson, RS., Manabe, I., Nagai, R., Komuro, I.
    • Journal Title

      Nature Communications

      Volume: 7 Issue: 1 Pages: 11635-11635

    • DOI

      10.1038/ncomms11635

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-26110005, KAKENHI-PLANNED-26111003, KAKENHI-PROJECT-26253049, KAKENHI-PROJECT-15H04824, KAKENHI-PROJECT-16H06145, KAKENHI-PROJECT-15K19369, KAKENHI-PROJECT-15K19372
  • [Journal Article] Cardiogenic syncope possibly related to bevacizumab-containing combination chemotherapy for advanced non-small cell lung cancer.2016

    • Author(s)
      Chino H, Amano Y, Yamauchi Y, Matsuda J, Takeda N, Tanaka G, Takai D, Nagase T.
    • Journal Title

      J Thorac Dis

      Volume: 8 Pages: 2646-2650

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-26111003
  • [Journal Article] The role of clock genes and circadian rhythm in the development of cardiovascular diseases.2015

    • Author(s)
      Takeda N, Maemura K.
    • Journal Title

      Cell Mol Life Sci

      Volume: 72 Issue: 17 Pages: 3225-3234

    • DOI

      10.1007/s00018-015-1923-1

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-26111003, KAKENHI-PROJECT-25461113
  • [Journal Article] Hypoxia Signaling Cascade for Erythropoietin Production in Hepatocytes.2015

    • Author(s)
      Tojo Y, Sekine H, Hirano I, Pan X, Souma T, Tsujita T, Kawaguchi S, Takeda N, Takeda K, Fong GH, Dan T, Ichinose M, Miyata T, Yamamoto M, Suzuki N.
    • Journal Title

      Mol Cell Biol.

      Volume: 35 Issue: 15 Pages: 2658-2672

    • DOI

      10.1128/mcb.00161-15

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26860623, KAKENHI-PROJECT-26860625, KAKENHI-PLANNED-26111002, KAKENHI-PLANNED-26111003, KAKENHI-PUBLICLY-26116702, KAKENHI-PROJECT-15H04691, KAKENHI-PROJECT-25461113, KAKENHI-PROJECT-25670157
  • [Journal Article] Necrostatin-1 protects against reactive oxygen species (ROS)-induced hepatotoxicity in acetaminophen-induced acute liver failure.2014

    • Author(s)
      Takemoto K, Hatano E, Iwaisako K, Takeiri M, Noma N, Ohmae S, Toriguchi K, Tanabe K, Tanaka H, Seo S, Taura K, Machida K, Takeda N, Saji S, Uemoto S, Asagiri M.
    • Journal Title

      FEBS Open Bio

      Volume: 4 Issue: 1 Pages: 777-787

    • DOI

      10.1016/j.fob.2014.08.007

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-14J06672, KAKENHI-PROJECT-24659822, KAKENHI-PROJECT-24689056, KAKENHI-PLANNED-26111003, KAKENHI-PROJECT-26461909
  • [Journal Article] Non-invasive diagnosis of coronary artery disease by 123I-BMIPP/201TlCl dual myocardial SPECT in patients with heart failure2014

    • Author(s)
      Abe H, Iguchi N, Utanohara Y, Inoue K, Takamisawa I, Seki A, Tanizaki K, Takeda N, Tohbaru T, Asano R, Nagayama M, Takayama M, Umemura J, Sumiyoshi T, Tomoike H.
    • Journal Title

      Int J Cardiol

      Volume: 176 Issue: 3 Pages: 969-974

    • DOI

      10.1016/j.ijcard.2014.08.129

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25461113, KAKENHI-PLANNED-26111003
  • [Journal Article] Regulation of wound healing and fibrosis by hypoxia and hypoxia-inducible factor-1.2014

    • Author(s)
      Ruthenborg RJ, Ban JJ, Wazir A, Takeda N, Kim JW.
    • Journal Title

      Mol Cells

      Volume: 37 Issue: 9 Pages: 637-643

    • DOI

      10.14348/molcells.2014.0150

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-26111003
  • [Journal Article] Angiotensin II impairs endothelial nitric-oxide synthase bioavailability under free cholesterol-enriched conditions via intracellular free cholesterol-rich membrane microdomains2013

    • Author(s)
      Amiya E, Watanabe M, Takeda N, Saito T, Shiga T, Hosoya Y, Nakao T, Imai Y, Manabe I, Nagai R, Komuro I, Maemura K.
    • Journal Title

      J Biol Chem

      Volume: 288 Issue: 20 Pages: 14497-509

    • DOI

      10.1074/jbc.m112.448522

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23790837, KAKENHI-PROJECT-25461113
  • [Journal Article] 2. VEGF-A induces its negative regulator, soluble form of VEGFR-1, by modulating its alternative splicing.2013

    • Author(s)
      Saito T, Takeda N, Amiya E, Nakao T, Abe H, Semba H, Soma K, Koyama K, Hosoya Y, Imai Y, Isagawa T, Watanabe M, Manabe I, Komuro I, Nagai R, Maemura K.
    • Journal Title

      FEBS Lett.

      Volume: 587 Pages: 2179-2185

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24591109
  • [Journal Article] Vegf-a induces its negative regulator, soluble form of vegfr-1, by modulating its alternative splicing.2013

    • Author(s)
      Saito T, Takeda N, Amiya E, Nakao T, Abe H, Semba H, Soma K, Koyama K, Hosoya Y, Imai Y, Isagawa T, Watanabe M, Manabe I, Komuro I, Nagai R, Maemura K.
    • Journal Title

      FEBS letters

      Volume: 587 Issue: 14 Pages: 2179-2185

    • DOI

      10.1016/j.febslet.2013.05.038

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25461113
  • [Journal Article] Circadian expressions of cardiac ion channel genes in mouse might be associated with the central clock in the SCN but not the peripheral clock in the heart.2013

    • Author(s)
      Tong M, Watanabe E, Yamamoto N, Nagahata-Ishiguro M, Maemura K, Takeda N, Nagai R, Ozaki Y.
    • Journal Title

      Biol Rhythm Res

      Volume: 44 Issue: 4 Pages: 519-530

    • DOI

      10.1080/09291016.2012.704801

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25461113
  • [Journal Article] 1. HIF isoforms in the skin differentially regulate systemic arterial pressure.2013

    • Author(s)
      Cowburn AS, Takeda N, Boutin AT, Kim JW, Sterling JC, Nakasaki M, Southwood M, Goldrath AW, Jamora C, Nizet V, Chilvers ER, Johnson RS.
    • Journal Title

      Proc Natl Acad Sci U S A

      Volume: 110 Pages: 17570-17575

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24591109
  • [Presentation] 酸素シグナルと心血管リモデリング2022

    • Author(s)
      武田憲彦
    • Organizer
      第86回日本循環器学会学術集会シンポジウム
    • Data Source
      KAKENHI-PROJECT-18H04122
  • [Presentation] 組織リモデリングにおける低酸素シグナル2019

    • Author(s)
      武田憲彦
    • Organizer
      第92回日本薬理学会年会
    • Invited
    • Data Source
      KAKENHI-PLANNED-26111003
  • [Presentation] Roles of Ly6Chi macrophages hypoxia signaling in cardiac fibrosis2019

    • Author(s)
      Norihiko Takeda
    • Organizer
      Keystone Symposium
    • Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-26111003
  • [Presentation] 低酸素シグナルを介する心臓リモデリング2018

    • Author(s)
      武田憲彦
    • Organizer
      第47回日本心脈管作動物質学会
    • Invited
    • Data Source
      KAKENHI-PLANNED-26111003
  • [Presentation] The roles of lactate metabolism in cardiac function2018

    • Author(s)
      武田憲彦
    • Organizer
      第82回日本循環器学会学術集会
    • Invited
    • Data Source
      KAKENHI-PLANNED-26111003
  • [Presentation] Genomewide analysis of HIF-1α target genes in macrophage adaptation for the microenvironment2018

    • Author(s)
      Isagawa T, Takeda N, Semba H, Morioka M, Maemura K.
    • Organizer
      第1回日本循環器学会基礎研究フォーラム
    • Data Source
      KAKENHI-PLANNED-26111003
  • [Presentation] The roles of glucose and lactate metabolism in the regulation of mitochondrial respiration2018

    • Author(s)
      武田憲彦
    • Organizer
      第6回低酸素研究会・酸素生物学領域国際シンポジウム
    • Invited
    • Data Source
      KAKENHI-PLANNED-26111003
  • [Presentation] The roles of glucose and lactate metabolism in the regulation of mitochondrial respiration2018

    • Author(s)
      Norihiko Takeda
    • Organizer
      Hypoxia Research Meeting
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-26111003
  • [Presentation] マクロファージ微小環境適応における転写制御機構2018

    • Author(s)
      砂河孝行, 武田憲彦, 仙波宏章,安部 元, 相馬 桂, 和氣正樹, 加藤愛巳, 森岡勝樹, 魏碩俣, 前村浩二
    • Organizer
      第47回日本心脈管作動物質学会
    • Data Source
      KAKENHI-PLANNED-26111003
  • [Presentation] The roles of hypoxia or inflammatory signals in cardiovascular remodeling2017

    • Author(s)
      Takeda N.
    • Organizer
      Special Research Seminar at 神戸女子薬科大学
    • Invited
    • Data Source
      KAKENHI-PLANNED-26111003
  • [Presentation] 低酸素誘導性肺血管リモデリングにおける炎症細胞の役割2017

    • Author(s)
      武田憲彦
    • Organizer
      第9回日本生理学会大会
    • Place of Presentation
      アクトシティ浜松、静岡
    • Year and Date
      2017-03-30
    • Invited
    • Data Source
      KAKENHI-PLANNED-26111003
  • [Presentation] Flt-1 in M1 macrophages promotes immature vascular formation2017

    • Author(s)
      Soma K, Takeda N, Isagawa T, Abe H, Semba H, Koyama K, Wake M, Kato M, Nakagama Y, Manabe I, Nagai R, Komuro I
    • Organizer
      European society of cardiology, ESC congress 2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-26111003
  • [Presentation] HIF-1alpha-PDK1 axis induced active glycolysis plays an essential role in macrophage migratory capacity.2017

    • Author(s)
      Takeda N.
    • Organizer
      Keystone Symposium “Adaptaions to Hypoxia in Physiology and Disease”
    • Place of Presentation
      Whistler Conference Centre, Whistler, British Columbia, Canada
    • Year and Date
      2017-03-09
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-26111003
  • [Presentation] The Role of Eosinophils in Pulmonary Arterial Remodelling2017

    • Author(s)
      武田憲彦
    • Organizer
      第81回日本循環器学会学術集会
    • Place of Presentation
      ホテル日航金沢、金沢
    • Year and Date
      2017-03-17
    • Invited
    • Data Source
      KAKENHI-PLANNED-26111003
  • [Presentation] The roles of lactate metabolism in cardiac function2017

    • Author(s)
      Takeda N.
    • Organizer
      Consortium of Biological Sciences 2017
    • Invited
    • Data Source
      KAKENHI-PLANNED-26111003
  • [Presentation] High-Throughput shRNA Screening of the Molecular Mechanisms in Cardiac Fibroblast Activation2017

    • Author(s)
      Koyama K, Takeda N, Abe H, Semba H, Soma K, Wake M, Katoh M, Nakagama Y, Isagawa T, Komuro I
    • Organizer
      European society of cardiology, ESC congress 2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-26111003
  • [Presentation] Switching of two HIF-alpha; isforms regulates inflammatory processes and cardiac remodeling2016

    • Author(s)
      武田憲彦
    • Organizer
      第52回高血圧関連疾患モデル学会
    • Place of Presentation
      秋葉原UDX、東京
    • Year and Date
      2016-09-22
    • Invited
    • Data Source
      KAKENHI-PLANNED-26111003
  • [Presentation] HIF-1α - PDK1 axis induced active glycolysis plays an essential role in macrophage migratory capacity2016

    • Author(s)
      Takeda N, Semba H, Isagawa T, Abe H, Sugiura Y, Honda K, Wake M, Kim JW, Soma K, Koyama K, Katoh M, Johnson RS, Manabe I, Nagai R, Komuro I
    • Organizer
      Keystone symposium; Immunometabolism in immune function and inflammatory disease
    • Place of Presentation
      Alberta, Canada
    • Year and Date
      2016-02-24
    • Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-26111003
  • [Presentation] HIF-1alpha-PDK1 axis induced active glycolysis plays an essential role in macrophage migratory capacity.2016

    • Author(s)
      Takeda N.
    • Organizer
      2016 HDRC International Symposium
    • Place of Presentation
      Incheon, Korea
    • Year and Date
      2016-06-17
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-26111003
  • [Presentation] Roles of Ly6Chi monocytes hypoxia signaling in cardiac remodeling2016

    • Author(s)
      Abe H, Takeda N, Semba H, Soma K, Koyama K, Wake M, Katoh M, Manabe I, Nagai R, Komuro I
    • Organizer
      Keystone symposium; Immunometabolism in immune function and inflammatory disease
    • Place of Presentation
      Alberta, Canada
    • Year and Date
      2016-02-22
    • Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-26111003
  • [Presentation] HIF-1alpha-PDK1経路を介した代謝リプログラミングはマクロファージ遊走能を促進する2016

    • Author(s)
      武田憲彦
    • Organizer
      第37回日本肥満学会
    • Place of Presentation
      東京ファッションタウン、東京
    • Year and Date
      2016-10-08
    • Invited
    • Data Source
      KAKENHI-PLANNED-26111003
  • [Presentation] Perivascular accumulation of M1 macrophages elicits the development of immature vascular formation.2016

    • Author(s)
      武田憲彦
    • Organizer
      第24回日本血管生物医学会学術集会
    • Place of Presentation
      長崎ブリックホール、長崎
    • Year and Date
      2016-12-10
    • Invited
    • Data Source
      KAKENHI-PLANNED-26111003
  • [Presentation] マクロファージ活性化における細胞内グルコース代謝の役割2016

    • Author(s)
      武田憲彦
    • Organizer
      第20回日本適応医学会学術集会
    • Place of Presentation
      東京コンベンションホール、東京
    • Year and Date
      2016-12-16
    • Invited
    • Data Source
      KAKENHI-PLANNED-26111003
  • [Presentation] HIF-1α - Pdk1 axis induced metabolic reprogramming critically regulates macrophage function in inflammatory conditions2016

    • Author(s)
      Semba H, Takeda N, Isagawa T, Wake M, Abe H, Soma K, Koyama K, Katoh M, Manabe I, Nagai R, Takeshi Yamashita, Komuro I
    • Organizer
      第80回日本循環器学会総会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2016-03-18
    • Data Source
      KAKENHI-PLANNED-26111003
  • [Presentation] 心血管リモデリングにおける炎症細胞・低酸素シグナルの役割2016

    • Author(s)
      武田憲彦
    • Organizer
      第48回日本動脈硬化学会総会学術集会
    • Place of Presentation
      京王プラザホテル、東京
    • Year and Date
      2016-07-14
    • Invited
    • Data Source
      KAKENHI-PLANNED-26111003
  • [Presentation] HIF-1αを介する解糖系代謝シフトはマクロファージ遊走能を促進する2015

    • Author(s)
      武田憲彦
    • Organizer
      第19回酸素ダイナミクス研究会
    • Place of Presentation
      東京女子医科大学 健保会館(東京都新宿区)
    • Year and Date
      2015-09-12
    • Data Source
      KAKENHI-PLANNED-26111003
  • [Presentation] Hypoxia induced metabolic reprograming in macrophages.2015

    • Author(s)
      Takeda N.
    • Organizer
      An International Symposium on Oxygen Biology
    • Place of Presentation
      早稲田大学 先端生命医科学センター/TWIns(東京都新宿区)
    • Year and Date
      2015-07-24
    • Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-26111003
  • [Presentation] 低酸素シグナルを介する心血管病態治療の可能性2015

    • Author(s)
      武田憲彦
    • Organizer
      第47回日本動脈硬化学会総会学術集会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2015-07-09
    • Invited
    • Data Source
      KAKENHI-PLANNED-26111003
  • [Presentation] 低酸素シグナルを介する心血管病態治療の可能性2015

    • Author(s)
      武田憲彦
    • Organizer
      第47回日本動脈硬化学会総会学術集会
    • Place of Presentation
      仙台国際センター(仙台市)
    • Year and Date
      2015-07-09
    • Invited
    • Data Source
      KAKENHI-PROJECT-25461113
  • [Presentation] HIF-1α-PDK1を介する解糖系代謝シフトがマクロファージ遊走能を促進する2015

    • Author(s)
      武田憲彦
    • Organizer
      第38回日本分子生物学会年会・第88回日本生化学会大会合同大会
    • Place of Presentation
      神戸国際会議場(神戸市)
    • Year and Date
      2015-12-01
    • Invited
    • Data Source
      KAKENHI-PROJECT-25461113
  • [Presentation] 炎症プロセスにおけるマクロファージ細胞内代謝調節機構の役割2015

    • Author(s)
      武田憲彦
    • Organizer
      脳心血管抗加齢研究会2015
    • Place of Presentation
      大阪梅田スカイビル(大阪府大阪市)
    • Year and Date
      2015-11-25
    • Invited
    • Data Source
      KAKENHI-PLANNED-26111003
  • [Presentation] M1マクロファージの集積遷延は腫瘍内血管の未熟化を引き起こす2015

    • Author(s)
      相馬桂 武田憲彦 砂河孝行 安部元 仙波宏章 小山雄広 和氣正樹 加藤愛巳 真鍋一郎 永井良三 小室一成
    • Organizer
      第23回日本血管生物医学会学術集会
    • Place of Presentation
      神戸国際会議場(兵庫県神戸市)
    • Year and Date
      2015-12-12
    • Data Source
      KAKENHI-PLANNED-26111003
  • [Presentation] Roles of Macrophages Hypoxia Signaling in Pressure Overload Induced Cardiac Remodeling2015

    • Author(s)
      Abe H, Takeda N, Semba H, Soma K, Koyama K, Wake M, Manabe I, Nagai R, Komuro I.
    • Organizer
      第79回日本循環器学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2015-04-24
    • Data Source
      KAKENHI-PLANNED-26111003
  • [Presentation] Roles of macrophages hypoxia signaling in pressure overload-induced cardiac remodeling2015

    • Author(s)
      Abe H, Takeda N, Semba H, Soma K, Koyama K, Wake M, Katoh M, Manabe I, Nagai R, Komuro I
    • Organizer
      第32回国際心臓研究学会日本部会
    • Place of Presentation
      神戸国際会議場(兵庫県神戸市)
    • Year and Date
      2015-12-10
    • Data Source
      KAKENHI-PLANNED-26111003
  • [Presentation] Perivascular accumulation of M1 macrophages elicits the development of immature vascular formation.2015

    • Author(s)
      Soma K, Takeda N, Isagawa T, Abe H, Semba H, Koyama K, Wake M, Manabe I, Nagai R, Komuro I
    • Organizer
      ESC Congress2015
    • Place of Presentation
      London, UK
    • Year and Date
      2015-09-01
    • Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-26111003
  • [Presentation] HIF-1α;-PDK1を介する解糖系代謝シフトがマクロファージ遊走能を促進する2015

    • Author(s)
      武田憲彦
    • Organizer
      第38回日本分子生物学会年会・第88回日本生化学会大会合同大会
    • Place of Presentation
      神戸国際会議場(兵庫県神戸市)
    • Year and Date
      2015-12-04
    • Invited
    • Data Source
      KAKENHI-PLANNED-26111003
  • [Presentation] マクロファージの代謝リプログラミングにおける細胞内低酸素センサー2014

    • Author(s)
      仙波宏章, 武田憲彦, 砂河孝行, 杉浦悠毅, 安部元, 相馬桂, 小山雄広, 和氣正樹, 真鍋一郎, 小室一成, 永井良三
    • Organizer
      第37回日本分子生物学会年会ワークショップ
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-11-26
    • Data Source
      KAKENHI-PLANNED-26111003
  • [Presentation] マクロファージの代謝リプログラミングにおける細胞内低酸素センサー2014

    • Author(s)
      仙波宏章、武田憲彦、砂河孝行、杉浦悠毅、安部元、相馬桂、小山雄広、和氣正樹、真鍋一郎、永井良三、小室一成
    • Organizer
      第37回日本分子生物学会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-11-26
    • Data Source
      KAKENHI-PROJECT-24591109
  • [Presentation] Roles of macrophage hypoxia signaling in cardiac remodeling2013

    • Author(s)
      Hajime Abe, Norihiko Takeda, Hiroaki Semba, Katsura Soma, Takayuki Isagawa, Ichiro Manabe, Ryozo Nagai, Issei Komuro
    • Organizer
      Keystone Symposium 2013
    • Place of Presentation
      Keystone, 米国
    • Data Source
      KAKENHI-PROJECT-24591109
  • [Presentation] 生活習慣病、心血管リモデリングにおける低酸素ストレスの役割2013

    • Author(s)
      武田憲彦
    • Organizer
      日本肥満学会
    • Place of Presentation
      東京(東京国際フォーラム)
    • Invited
    • Data Source
      KAKENHI-PROJECT-24591109
  • [Presentation] Hypoxic responses of M1 macrophages are critical for the regulation of cardiac fibrosis2012

    • Author(s)
      Hajime Abe, Norihiko Takeda, Hiroaki Semba, Katsura Soma, Takayuki Isagawa, Ichiro Manabe, Ryozo Nagai, Issei Komuro
    • Organizer
      AHA Scientific Session 2012
    • Place of Presentation
      Los Angeles, 米国
    • Data Source
      KAKENHI-PROJECT-24591109
  • [Presentation] Transcriptional Regulation:Role of Clock Genes and Circadian Rhythm in the Development of Cardiovascular Diseases

    • Author(s)
      Koji Maemura, Norihiko Takeda, Tomoko Nakao, Hiroyuki Morita, Hiroaki Kawano
    • Organizer
      The 18th International Vascular Biology Meeting
    • Place of Presentation
      京都みやこメッセ(京都市)
    • Year and Date
      2014-04-14 – 2014-04-17
    • Invited
    • Data Source
      KAKENHI-PROJECT-25461113
  • 1.  Isagawa Takayuki (40418637)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 3 results
  • 2.  SEMBA HIROAKI (80747923)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 1 results
  • 3.  MAEMURA Koji (90282649)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 4 results
  • 4.  Nangaku Masaomi (90311620)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 5.  SUGIMOTO Hiroki (70515866)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 6.  Mori Yasuo (80212265)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 7.  Sakamoto Masaya (40419742)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  Maki Hisataka (00748147)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  Kotani Kiyoshi (00372409)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 10.  Matsumoto Shingo (90741041)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 11.  合田 亘人 (00245549)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 12.  山本 雅之 (50166823)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  井上 正宏 (10342990)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 14.  赤池 孝章 (20231798)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  西田 基宏 (90342641)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  浦野 泰照 (20292956)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  飛田 成史 (30164007)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  中川 秀彦 (80281674)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  松原 大祐 (80415554)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  柴 綾 (50708427)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  伊東 剛 (20733075)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  村上 善則 (30182108)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  大野 和寿 (50867520)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  MIKI hiroaki
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  MIURA kyoko
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 26.  SUMIMOTO hideki
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 27.  ITOH ken
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 28.  UCHIDA kouji
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 29.  Matsutani Diasuke
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 30.  AMIYA Eisuke
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 31.  Nakagama Yu
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 32.  ENDO Hiroko
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 33.  YAMAGUCHI Yoshifumi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 34.  UTSUNOMIYA Kazunori
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 35.  YONEZAWA Tomo
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 36.  SAITO Taku
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 37.  平田 陽一郎
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 38.  犬塚 亮
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 39.  山本 正道
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 40.  宮田 敬士
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 41.  中山 恒
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 42.  清水 良子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 43.  篠原 正浩
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 44.  相馬 友和
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 45.  倉田 里穂
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 46.  岡田 慶太
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 47.  森 大典
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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