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IJUIN Ryosuke  伊集院 良祐

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… Alternative Names

伊集院 良祐  イジュウイン リョウスケ

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Researcher Number 40442925
Other IDs
Affiliation (Current) 2025: 東京薬科大学, 薬学部, 助教
Affiliation (based on the past Project Information) *help 2013 – 2017: 東京薬科大学, 薬学部, 助教
2010 – 2012: 独立行政法人理化学研究所, 分子イメージング創薬化学研究チーム, 研究員
2007 – 2008: The Institute of Physical and Chemical Research, 分子プローブ設計創薬研究チーム, 研究員
Review Section/Research Field
Principal Investigator
Drug development chemistry
Except Principal Investigator
Drug development chemistry
Keywords
Principal Investigator
高速化学反応 / クロスカップリング / PET / 陽電子画像診断法 / 固相反応 / 神経因性疼痛 / 酵素阻害剤 / ポジトロン / 一酸化窒素合成酵素
Except Principal Investigator
ホスホン酸エステル … More / 血液凝固 / 酵素阻害 / セリンプロテアーゼ / トロンビン / 非競合阻害剤 / ホスホネート / セリンプロテアーゼ阻害剤 / PET / 11C-標識法 / 高速C-[11C]メチル化 / 高速C-メチル化 / アルキル-アルキル間高速クロスカップリング反応 / 鈴木・宮浦反応 / パラジウム触媒 / ボロン化合物 / 高速反応 / アルキル-アルキル間クロスカップリング反応 / PETプローブ合成 Less
  • Research Projects

    (4 results)
  • Research Products

    (33 results)
  • Co-Researchers

    (6 People)
  •  Basic pharmaceutical study of relationship between phosphorus atom introduction and non-competition of inhibitor

    • Principal Investigator
      Aoyama Hiroshi
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Drug development chemistry
    • Research Institution
      Tokyo University of Pharmacy and Life Science
  •  Development of rapid C-methylation between two sp3-hybridized carbons for incorporation of short-lived positron-emitting 11C radionuclide

    • Principal Investigator
      Koyama Hiroko
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Drug development chemistry
    • Research Institution
      Gifu University
  •  Development of rapid methylation reaction using polymer supported palladium complexPrincipal Investigator

    • Principal Investigator
      IJUIN Ryosuke
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Drug development chemistry
    • Research Institution
      The Institute of Physical and Chemical Research
  •  Development of nitric oxide synthase probes for PET imagingPrincipal Investigator

    • Principal Investigator
      IJUIN Ryosuke
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Young Scientists (Start-up)
    • Research Field
      Drug development chemistry
    • Research Institution
      The Institute of Physical and Chemical Research

All 2015 2014 2013 2012 2011 2008

All Journal Article Presentation Patent

  • [Journal Article] Discovery of non-competitive thrombin inhibitor derived from competitive tryptase inhibitor skeleton: Shift in molecular recognition resulted from skeletal conversion of carboxylate into phosphonate2015

    • Author(s)
      Hiroshi Aoyama, Ryosuke Ijuin, Jun-ya Kato, Sarasa Urushiyama, Masashi Tetsuhashi, Yuichi Hashimoto, Tsutomu Yokomatsu
    • Journal Title

      Bioorganic and Medicinal Chemistry Letters

      Volume: 25 Issue: 17 Pages: 3676-3680

    • DOI

      10.1016/j.bmcl.2015.06.039

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15K08033, KAKENHI-PROJECT-25460155
  • [Journal Article] Synthesis of poly-substituted pyrazolo[1,5-a]quinolines through one-pot two component cascade reaction2014

    • Author(s)
      J. Kato, R. Ijuin, H. Aoyama, T. Yokomatsu
    • Journal Title

      Tetrahedron

      Volume: 70 Issue: 17 Pages: 2766-2775

    • DOI

      10.1016/j.tet.2014.02.081

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25460147
  • [Journal Article] Pd0-Mediated Rapid Coupling of Methyl Iodide with Excess Amounts of Benzyl- and Cinnamylboronic Acid Esters: Efficient Method for Incorporation of Positron–Emitting 11C Radionuclide into Organic Frameworks by Coupling between Two sp3-Hybridized Carbons2013

    • Author(s)
      Hiroko Koyama, Zhouen Zhang, Ryosuke Ijuin, Siqin, Jeongwan Son, Yuma Hatta, Masashi Ohta, Masahiro Wakao, Takamitsu Hosoya, Hisashi Doi, Masaaki Suzuki
    • Journal Title

      RSC Advances

      Volume: 3 Issue: 24 Pages: 9391-9401

    • DOI

      10.1039/c3ra40815a

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25242070, KAKENHI-PROJECT-25460147
  • [Journal Article] Evaluation of Oatp and Mrp2 activities in hepatobiliary excretion using newly developed positron emission tomography tracer [11C]dehydropravastatin in rats.2013

    • Author(s)
      Shingaki T, Takashima T, Ijuin R, Zhang X, Onoue T, Katayama Y, Okauchi T, Hayashinaka E, Cui Y, Wada Y, Suzuki M, Maeda K, Kusuhara H, Sugiyama Y, Watanabe Y.
    • Journal Title

      J Pharmacol Exp Ther

      Volume: 347 Issue: 1 Pages: 193-202

    • DOI

      10.1124/jpet.113.206425

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-23136101, KAKENHI-PROJECT-24229002, KAKENHI-PROJECT-24659574, KAKENHI-PROJECT-25242070, KAKENHI-PROJECT-25460147
  • [Journal Article] Novel Strategy for Synthesis of Substituted Benzimidazo[1,2-a]quinolines2013

    • Author(s)
      Jun-ya Kato, Yutaro Ito, Ryosuke Ijuin, Hiroshi Aoyama, Tsutomu Yokomatsu
    • Journal Title

      Organic Letters

      Volume: 15 Issue: 14 Pages: 3794-3797

    • DOI

      10.1021/ol4017723

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24790119, KAKENHI-PROJECT-25460147
  • [Journal Article] Positron emission tomography (PET) imaging-based evaluation of hepatobiliary transport in humans using 15R-[^<11>C]TIC-Me2012

    • Author(s)
      T.Takashima, S.Kitamura, Y.Wada, M.Tanaka, Y.Shigihara, H.Ishii, R.Ijuin, S.Shiomi, T.Nakae, Y.Watanabe, Y.Cui, H.Doi, M.Suzuki, K.Maeda, H.Kusuhara, Y.Sugiyama, Y.Watanabe
    • Journal Title

      Journal of Nuclear Medicine

      Volume: (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22790121
  • [Journal Article] Positron emission tomography (PET) imaging-based evaluation of hepatobiliary transport in humans using 15R-[^<11>C]TIC-Me2012

    • Author(s)
      Tadayuki Takashima, Satoshi Kitamura, Yasuhiro Wada, Masaaki Tanaka, Yoshihito Shigihara, Hideki Ishii, Ryosuke Ijuin, Susumu Shiomi, Takahiro Nakae, Yumiko Watanabe, Yilong Cui, Hisashi Doi, Masaaki Suzuki, Kazuya Maeda, Hiroyuki Kusuhara, Yuichi Sugiyama and Yasuyoshi Watanabe
    • Journal Title

      J. Nucl. Med.

      Volume: 53 Issue: 5 Pages: 741-748

    • DOI

      10.2967/jnumed.111.098681

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22790121, KAKENHI-PROJECT-23300241, KAKENHI-PROJECT-24229002
  • [Journal Article] Synthesis of [^<11>C]Dehydropravastatin, a PET Probe Potentially Useful for Studying OATP1B1 and MRP2 Transporters in the Liver2012

    • Author(s)
      Ryosuke Ijuin, Tadayuki Takashima, Yasuyoshi Watanabe, Yuichi Sugiyama and Masaaki Suzuki
    • Journal Title

      Bioorg. Med. Chem.

      Volume: 20 Issue: 12 Pages: 3703-3709

    • DOI

      10.1016/j.bmc.2012.04.051

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22790121, KAKENHI-PROJECT-24229002
  • [Patent] 高速メチル化法(アルキル炭素上への短寿命放射性核種^<11>C の効果的導入法)2012

    • Inventor(s)
      鈴木正昭、伊集院良祐、土居久志、古山浩子
    • Industrial Property Rights Holder
      同上
    • Filing Date
      2012-07-18
    • Data Source
      KAKENHI-PROJECT-22790121
  • [Patent] プラバスタチン類縁体、その前駆体、PET 用分子プローブ及びトランスポーター機能評価用プローブ2012

    • Inventor(s)
      鈴木正昭、伊集院良祐、高島忠之、渡辺恭良、杉山雄一、前田和哉
    • Industrial Property Rights Holder
      同上
    • Filing Date
      2012-05-01
    • Data Source
      KAKENHI-PROJECT-22790121
  • [Patent] 高速メチル化法(アルキル炭素上への短寿命放射性核種11Cの効果的導入法)2012

    • Inventor(s)
      鈴木正昭、伊集院良祐、土居久志、古山浩子
    • Industrial Property Rights Holder
      鈴木正昭、伊集院良祐、土居久志、古山浩子
    • Industrial Property Rights Type
      特許
    • Filing Date
      2012-07-18
    • Data Source
      KAKENHI-PROJECT-22790121
  • [Patent] プラバスタチン類縁体、その前駆体、PET用分子プローブ及びトランスポーター機能評価用プローブ2012

    • Inventor(s)
      鈴木正昭、伊集院良祐、高島忠之、渡辺恭良、杉山雄一、前田和哉
    • Industrial Property Rights Holder
      鈴木正昭、伊集院良祐、高島忠之、渡辺恭良、杉山雄一、前田和哉
    • Industrial Property Rights Type
      特許
    • Filing Date
      2012-05-01
    • Data Source
      KAKENHI-PROJECT-22790121
  • [Presentation] Pd0–Mediated Rapid Coupling of Methyl Iodide with Excess Amounts of Benzyl- or Cinnamylboronic Acid Esters (sp3–sp3 Type Coupling) for the Incorporation of Positron–Emitting 11C Radionuclide into an Organic Framework2012

    • Author(s)
      Hiroko Koyama, Ryosuke Ijuin, Siqin, Yuma Hatta, Jeongwan Son, Masashi Ohta, Masahiro Wakao, Takamitsu Hosoya, Hisashi Doi and Masaaki Suzuki
    • Organizer
      World Molecular Imaging Congress 2012
    • Place of Presentation
      Dublin/Ireland
    • Data Source
      KAKENHI-PROJECT-22790121
  • [Presentation] Synthesis of [^<11>C]dehydropravastatin designed as a PET probe for in vivo study on the functions of OATP1B1 and MRP2 transporters in the liver2012

    • Author(s)
      Ryosuke Ijuin, Tadayuki Takashima, Yasuyoshi Watanabe, Yuichi Sugiyama and Masaaki Suzuki
    • Organizer
      World Molecular Imaging Congress 2012
    • Place of Presentation
      Dublin
    • Data Source
      KAKENHI-PROJECT-22790121
  • [Presentation] [^<11>C]Dehydropravastatin の合成-肝トランスポーター機能評価のためのPET プローブ開発に向けて2012

    • Author(s)
      伊集院良祐、高島忠之、渡辺恭良、杉山雄一、鈴木正昭
    • Organizer
      日本薬学会第132 年会
    • Place of Presentation
      札幌
    • Data Source
      KAKENHI-PROJECT-22790121
  • [Presentation] Pd^0-Mediated Rapid Coupling of Methyl Iodide with Excess Amounts of Benzyl- or Cinnamylboronic Acid Esters (sp^3-sp^3 Type Coupling) for the Incorporation of Positron?Emitting ^<11>C Radionuclide into an Organic Framework2012

    • Author(s)
      Hiroko Koyama, Ryosuke Ijuin, Siqin, Yuma Hatta, Jeongwan Son, Masashi Ohta, Masahiro Wakao, Takamitsu Hosoya, Hisashi Doi and Masaaki Suzuki
    • Organizer
      World Molecular Imaging Congress 2012
    • Place of Presentation
      Dublin
    • Data Source
      KAKENHI-PROJECT-22790121
  • [Presentation] PETを活用した[11C]dehydropravastatinのトランスポーターを介した肝胆系輸送の定量的評価2012

    • Author(s)
      Tadayuki Takashima, Ryosuke Ijuin, Yumiko Katayama, Takashi Okauchi, Yasuhiro Wada, Masaaki Suzuki, Kazuya Maeda, Hiroyuki Kusuhara, Yuichi Sugiyama and Yasuyoshi Watanabe
    • Organizer
      第27回日本薬物動態学会
    • Place of Presentation
      千葉
    • Data Source
      KAKENHI-PROJECT-22790121
  • [Presentation] 肝トランスポーター機能評価のための[11C]dehydropravastatin PETプローブの合成2012

    • Author(s)
      伊集院良祐、高島忠之、渡辺恭良、杉山雄一、鈴木正昭
    • Organizer
      日本ケミカルバイオロジー学会 第7回年会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-22790121
  • [Presentation] Noninvasive Analysis of Transporter-mediated Drug-Drug Interaction in Hepatobiliary Transport: PET Studies using [11C]Dehydropravastatin and [11C]Telmisartan2012

    • Author(s)
      Tadayuki Takashima, Ryosuke Ijuin, Yoshinobu Hashizume, Yumiko Katayama, Yasuhiro Wada, Masaaki Suzuki, Kazuya Maeda, Yuichi Sugiyama, Yasuyoshi Watanabe
    • Organizer
      World Molecular Imaging Congress 2012
    • Place of Presentation
      Dublin/Ireland
    • Data Source
      KAKENHI-PROJECT-22790121
  • [Presentation] Pd0-Mediated Rapid Coupling of Methyl Iodide with Excess Amounts of Benzyl- and Cinnamylboronates: Efficient Method for Incorporation of Positron-Emitting 11C Radionuclide into Organic Frameworks by Coupling between sp3-Hybridized Carbons2012

    • Author(s)
      Hiroko Koyama, Ryosuke Ijuin, Jeongwan Son, Siqin, Yuma Hatta, Masashi Ohta, Masahiro Wakao, Takamitsu Hosoya, Hisashi Doi, Masaaki Suzuki
    • Organizer
      The Twelfth International Kyoto Conference on New Aspects of Organic Chemistry
    • Place of Presentation
      Kyoto/Japan
    • Data Source
      KAKENHI-PROJECT-22790121
  • [Presentation] Analysis of OATP and MRP2 Function in Hepatobiliary Transport using Positron Emission Tomography with [11C]Dehydropravastatin2012

    • Author(s)
      Tadayuki Takashima, Ryosuke Ijuin, Yumiko Katayama, Yasuhiro Wada, Takashi Okauchi, Masaaki Suzuki, Kazuya Maeda, Yuichi Sugiyama, Yasuyoshi Watanabe
    • Organizer
      11th International Symposium on the Synthesis and Applications of Isotopes and Isotopically Labelled Compounds
    • Place of Presentation
      Heidelberg/Germany
    • Data Source
      KAKENHI-PROJECT-22790121
  • [Presentation] [^<11>C]Dehydropravastatinの合成-肝トランスポーク機能評価のためのPETプローブ開発に向けて2012

    • Author(s)
      伊集院良祐, 高島忠之、渡辺恭良、杉山雄一、鈴木正昭
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      北海道大学(北海道)
    • Year and Date
      2012-03-30
    • Data Source
      KAKENHI-PROJECT-22790121
  • [Presentation] PET を活用した[^<11>C]dehydropravastatin のトランスポーターを介した肝胆系輸送の定量的評価2012

    • Author(s)
      Tadayuki Takashima, Ryosuke Ijuin, Yumiko Katayama, Takashi Okauchi, Yasuhiro Wada, Masaaki Suzuki, Kazuya Maeda, Hiroyuki Kusuhara, Yuichi Sugiyama and Yasuyoshi Watanabe
    • Organizer
      第27回日本薬物動態学会
    • Place of Presentation
      千葉
    • Data Source
      KAKENHI-PROJECT-22790121
  • [Presentation] Synthesis of [11C]dehydropravastatin designed as a PET probe for in vivo study on the functions of OATP1B1 and MRP2 transporters in the liver2012

    • Author(s)
      Ryosuke Ijuin, Tadayuki Takashima, Yasuyoshi Watanabe, Yuichi Sugiyama and Masaaki Suzuki
    • Organizer
      World Molecular Imaging Congress 2012
    • Place of Presentation
      Dublin/Ireland
    • Data Source
      KAKENHI-PROJECT-22790121
  • [Presentation] Analysis of OATP and MRP2 Function in Hepatobiliary Transport using Positron Emission Tomography with [^<11>C]Dehydropravastatin2012

    • Author(s)
      Tadayuki Takashima, Ryosuke Ijuin, Yumiko Katayama, Yasuhiro Wada, Takashi Okauchi, Masaaki Suzuki, Kazuya Maeda, Yuichi Sugiyama, Yasuyoshi Watanabe
    • Organizer
      11th International Symposium on the Synthesis and Applications of Isotopes and Isotopically Labelled Compounds
    • Place of Presentation
      Heidelberg
    • Data Source
      KAKENHI-PROJECT-22790121
  • [Presentation] Pd^0-Mediated Rapid Coupling of Methyl Iodide with Excess Amounts of Benzyl- and Cinnamylboronates: Efficient Method for Incorporation of Positron-Emitting ^<11>C Radionuclide into Organic Frameworks by Coupling between sp^3-Hybridized Carbons2012

    • Author(s)
      Hiroko Koyama, Ryosuke Ijuin, Jeongwan Son, Siqin, Yuma Hatta, Masashi Ohta, Masahiro Wakao, Takamitsu Hosoya, Hisashi Doi, Masaaki Suzuki
    • Organizer
      The Twelfth International Kyoto Conference on New Aspects of Organic Chemistry
    • Place of Presentation
      Kyoto
    • Data Source
      KAKENHI-PROJECT-22790121
  • [Presentation] 肝トランスポーター機能評価のための[^<11>C]dehydropravastatin PET プローブの合成2012

    • Author(s)
      伊集院良祐、高島忠之、渡辺恭良、杉山雄一、鈴木正昭
    • Organizer
      日本ケミカルバイオロジー学会 第7回年会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-22790121
  • [Presentation] Noninvasive Analysis of Transporter-mediated Drug-Drug Interaction in Hepatobiliary Transport: PET Studies using [^<11>C]Dehydropravastatin and [^<11>C]Telmisartan2012

    • Author(s)
      Tadayuki Takashima, Ryosuke Ijuin, Yoshinobu Hashizume, Yumiko Katayama, Yasuhiro Wada, Masaaki Suzuki, Kazuya Maeda, Yuichi Sugiyama, Yasuyoshi Watanabe
    • Organizer
      World Molecular Imaging Congress 2012
    • Place of Presentation
      Dublin
    • Data Source
      KAKENHI-PROJECT-22790121
  • [Presentation] Evaluation of in vivo Hepatobiliary Transport Using Positron Emission Tomography (PET): Studies in Rats and Application to Microdosing Clinical Studies2011

    • Author(s)
      Tadayuki Takashima, Hiroko Nagata, Hideki Ishii, Ryosuke Ijuin, Takahiro Nakae, Masaaki Tanaka, Yoshihito Shigihara, Suzuka Ataka, Hisashi Doi, Yasuhiro Wada, Kazuya Maeda, Hiroyuki Kusuhara, Yuichi Sugiyama and Yasuyoshi Watanabe
    • Organizer
      9th International ISSX Meeting
    • Place of Presentation
      Istanbul
    • Data Source
      KAKENHI-PROJECT-22790121
  • [Presentation] Design and Synthesis of High-Performance Molecular Probes-疾患対応型高機能分子プローブの開発2008

    • Author(s)
      伊集院 良祐
    • Organizer
      分子イメージング研究シンポジウムMolecular Imaging2008-飛躍を迎えた創薬・疾患診断研究-
    • Place of Presentation
      神戸国際会議場
    • Data Source
      KAKENHI-PROJECT-19890272
  • [Presentation] Development of disease-oriented probes for PET imaging2008

    • Author(s)
      鈴木 正昭, 伊集院 良祐
    • Organizer
      分子イメージングシンポジウム(ポスター発表)
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2008-01-28
    • Data Source
      KAKENHI-PROJECT-19890272
  • [Presentation] Development of disease-oriented probes for PET imaging2008

    • Author(s)
      伊集院 良祐
    • Organizer
      分子イメージングシンポジウム
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2008-01-28
    • Data Source
      KAKENHI-PROJECT-19890272
  • [Presentation] Design and Synthesis of High-Performance Molecular Probes-疾患対応型高機能分子プローブの開発2008

    • Author(s)
      伊集院良祐
    • Organizer
      分子イメージング研究シンポジウム Molecular Imaging 2008-飛躍を迎えた創薬・疾患診断研究-
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-19890272
  • 1.  Koyama Hiroko (50402160)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 2.  Aoyama Hiroshi (40374699)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 3.  DOI Hisashi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 4.  鈴木 正昭
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 5.  楠原 洋之
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 6.  前田 和哉
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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