YAMASHITA Hirotaka 山下弘高

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Yamashita Hirotaka 山下弘高

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Researcher Number	40453055
Other IDs	https://orcid.org/0000-0001-7028-7308
Affiliation (Current)	2024: 琉球大学, 医学(系)研究科(研究院), 准教授
Affiliation (based on the past Project Information) *help	2020 – 2022: 琉球大学, 医学(系)研究科(研究院), 准教授 2018 – 2019: 岐阜薬科大学, 薬学部, 講師 2016 – 2017: 岐阜薬科大学, 薬学部, 助教 2010 – 2011: 岐阜薬科大学, 薬学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 49070:Immunology-related / Biological pharmacy Except Principal Investigator Basic Section 08030:Family and consumer sciences, and culture and living-related / Eating habits
Keywords	Principal Investigator 経口免疫寛容 / 食物アレルギー / 皮膚感作 / 経皮感作 / 免疫学 Except Principal Investigator オリゴ糖 / N－グリカン / 豆類 / ペプチド / 機能性 … More / ACE阻害 / 腸内細菌 / アクアファバ / 煮汁 / 豆 / Ｎ－グリカン / ラフィノース族 / プレバイオティック / プレバイオティクス / いんげん豆 / 小豆 / 免疫調節 / N-グリカン / M3FX / 高機能性 / 抗アレルギー / スタキオース / ラフィノース / いんげん Less

新規食品素材「アクアファバ」に含まれる遊離型オリゴ糖・ペプチドの構造と機能解析
- Principal Investigator
  
  木村万里子
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 08030:Family and consumer sciences, and culture and living-related
- Research Institution
  Kobe Women's University
"Allergy via Intestine" and "Allergy via Skin"Principal Investigator
- Principal Investigator
  
  Yamashita Hirotaka
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  University of the Ryukyus
  Gifu Pharmaceutical University
Structural and functional analyses of bioactive oligosaccharides in kidney beans.
- Principal Investigator
  
  Kimura Mariko
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Eating habits
- Research Institution
  Kobe Women's University
The approach for therapy of food allergy to use mouse modelPrincipal Investigator
- Principal Investigator
  
  YAMASHITA Hirotaka
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Gifu Pharmaceutical University

All 2023 2022 2021 2020 2019 2018 2017 2016 2012 2011 2010

All Journal Article Presentation

[Journal Article] Oral allergy induction through skin exposure to previously tolerated food antigens in murine models2023
- Author(s)
  Yamashita Hirotaka、Matsuhara Hiroki、Tanaka Hiroyuki、Inagaki Naoki、Tsutsui Masato
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 152 Issue: 2 Pages: 76-85
- DOI
  10.1016/j.jphs.2023.03.003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07611
[Journal Article] Prophylactic steroid use is ineffective in food allergy: A randomized‐controlled clinical trial and a murine model2022
- Author(s)
  Matsui Teruaki、Yamashita Hirotaka、Kitamura Katsumasa、Makino Atsushi、Takasato Yoshihiro、Sugiura Shiro、Ito Komei
- Journal Title
  
  Allergy
  
  Volume: 78 Issue: 2 Pages: 537-539
- DOI
  10.1111/all.15451
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07611
[Journal Article] Spontaneous pulmonary emphysema in mice lacking all three nitric oxide synthase isoforms2021
- Author(s)
  Kato Kaori、Tsutsui Masato、Noguchi Shingo、Iha Yukitoshi、Naito Keisuke、Ogoshi Takaaki、Nishida Chinatsu、Tahara Masahiro、Yamashita Hirotaka、Wang Ke-Yong、Toyohira Yumiko、Yanagihara Nobuyuki、Masuzaki Hiroaki、Shimokawa Hiroaki、Tanimoto Akihide、Yatera Kazuhiro
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 22088-22088
- DOI
  10.1038/s41598-021-01453-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K00904, KAKENHI-PROJECT-19K08657, KAKENHI-PROJECT-19K07611, KAKENHI-PROJECT-20K08912
[Journal Article] Impact of orally-administered oligosaccharides in a murine model of food allergy2021
- Author(s)
  Yamashita Hirotaka、Shigemori Akari、Murata Misato、Tanaka Hiroyuki、Inagaki Naoki、Tsutsui Masato、Kimura Mariko
- Journal Title
  
  Journal of Functional Foods
  
  Volume: 85 Pages: 104643-104643
- DOI
  10.1016/j.jff.2021.104643
- NAID
  120007168804
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07611, KAKENHI-PROJECT-21K02101
[Journal Article] Staphylococcal Phage in Combination with Staphylococcus epidermidis as a Potential Treatment for Staphylococcus aureus-Associated Atopic Dermatitis and Suppressor of Phage-Resistant Mutants2020
- Author(s)
  Shimamori Yuzuki、Mitsunaka Shoichi、Yamashita Hirotaka、Suzuki Tohru、Kitao Tomoe、Kubori Tomoko、Nagai Hiroki、Takeda Shigeki、Ando Hiroki
- Journal Title
  
  Viruses
  
  Volume: 13 Issue: 1 Pages: 7-7
- DOI
  10.3390/v13010007
- NAID
  120007168806
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07611, KAKENHI-PROJECT-15K21770
[Journal Article] Convenient preparation of an antigenic oligosaccharide from white kidney bean powder: A useful plant oligosaccharide for synthesis of immunoactive glycopolymer.2020
- Author(s)
  Kimura M, Ogura M, Akamatsu M, Sugimoto K, Maeda M, Nitoda T, Nagasawa-Fujimori H, Yamashita H, Kimura Y.
- Journal Title
  
  Int J Biol Macromol.
  
  Volume: 153 Pages: 1016-1023
- DOI
  10.1016/j.ijbiomac.2019.10.231
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K05559, KAKENHI-PROJECT-16K00834, KAKENHI-PROJECT-17K08197
[Journal Article] Food allergy is linked to season of birth, sun exposure, and vitamin D deficiency2019
- Author(s)
  Matsui T, Tanaka K, Yamashita H, Saneyasu K, Tanaka H, Takasato Y, Sugiura S, Inagaki N, and, Ito K.
- Journal Title
  
  Allergol. Int.
  
  Volume: 68 Issue: 2 Pages: 172-177
- DOI
  10.1016/j.alit.2018.12.003
- NAID
  130007633563
- ISSN
  1323-8930, 1440-1592
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K00834
[Journal Article] 特集2　経口免疫寛容経口免疫寛容の誘導における食品添加物の影響2019
- Author(s)
  山下弘高、田中宏幸、稲垣直樹
- Journal Title
  
  臨床免疫・アレルギー科
  
  Volume: 71(2) Pages: 146-152
- Data Source
  KAKENHI-PROJECT-16K00834
[Journal Article] Immune suppression of food allergy by maternal IgG in murine models2018
- Author(s)
  Yamashita Hirotaka、Hayashi Tadamasa、Saneyasu Kenichi、Matsuhara Hiroki、Matsui Teruaki、Tanaka Hiroyuki、Inagaki Naoki
- Journal Title
  
  Allergol. Int.
  
  Volume: 67 Issue: 4 Pages: 506-514
- DOI
  10.1016/j.alit.2018.04.001
- ISSN
  1323-8930, 1440-1592
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K00834
[Journal Article] Eppikajutsuto protects against food allergy induced by ovalbumin in a murine model.2017
- Author(s)
  Matsui T, Yamashita H, Mori M, Tanaka H, and Inagaki N.
- Journal Title
  
  International Archives of Allergy and Immunology
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K00834
[Journal Article] Artificial sweeteners and mixture of food additives cause to break oral tolerance and induce food allergy in murine oral tolerance model for food allergy.2017
- Author(s)
  Yamashita H, Matsuhara H, Miotani S, Sako Y, Matsui T, Tanaka H, and Inagaki N.
- Journal Title
  
  Clinical and Experimental Allergy
  
  Volume: in press Issue: 9 Pages: 1204-1213
- DOI
  10.1111/cea.12928
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K00834
[Journal Article] Overcoming food allergy through acquired tolerance conferred by transfer of Tregs in a murine model2012
- Author(s)
  Hirotaka Yamashita, Keita Takahashi, Hiroyuki Tanaka, Hiroichi Nagai and Naoki Inagaki
- Journal Title
  
  Allergy
  
  Volume: 67(2) Issue: 2 Pages: 201-209
- DOI
  10.1111/j.1398-9995.2011.02742.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790075
[Presentation] マウス食物アレルギーモデルによる皮膚を介した食物抗原の暴露により経口免疫寛容を破たんさせる方法の探索2022
- Author(s)
  山下弘高、伊波幸紀、田中宏幸、稲垣直樹、筒井正人
- Organizer
  第75回日本薬理学会西南部会
- Data Source
  KAKENHI-PROJECT-19K07611
[Presentation] マウス食物アレルギーモデルを用いた食物アレルギーの発症における経口免疫寛容と経皮的な抗原負荷のバランスの解析2022
- Author(s)
  山下弘高、田中宏幸、稲垣直樹、筒井正人
- Organizer
  第95回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-19K07611
[Presentation] Acquired oral immune tolerance was overridden by exposure of food antigen via skin to use murine food allergy models2022
- Author(s)
  山下弘高、伊波幸紀、田中宏幸、稲垣直樹、筒井正人
- Organizer
  第96回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-19K07611
[Presentation] マウス食物アレルギーモデルによる食品添加物が食物アレルギーの発症に及ぼす影響について2022
- Author(s)
  山下弘高
- Organizer
  第6 回黒潮カンファレンス
- Invited
- Data Source
  KAKENHI-PROJECT-19K07611
[Presentation] 豆煮汁に含まれる機能性オリゴ糖とそれらのビフィズス菌増殖促進活性2021
- Author(s)
  笹田歩佳、荒木作彩、吉田和利、山本勇、前田恵、木村吉伸、山下弘高、木村万里子
- Organizer
  第60回　日本栄養・食糧学会　近畿支部大会（神戸女子大学　オンライン開催）
- Data Source
  KAKENHI-PROJECT-21K02101
[Presentation] マウス食物アレルギーモデルを用いた経口免疫寛容に対する経皮的な食物抗原暴露の影響2021
- Author(s)
  山下弘高、田中宏幸、稲垣直樹、筒井正人
- Organizer
  第74回日本薬理学会西南部会
- Data Source
  KAKENHI-PROJECT-19K07611
[Presentation] マウスモデルを用いた食物アレルギーの発症に及ぼす食品添加物の影響についての検討2020
- Author(s)
  山下弘高、田中宏幸、稲垣直樹、筒井正人
- Organizer
  第73回日本薬理学会西南部会
- Data Source
  KAKENHI-PROJECT-19K07611
[Presentation] 豆類の熱水抽出物に含まれるオリゴ糖の構造特性および抗アレルギー作用2020
- Author(s)
  笹田歩佳、松下夏子、吉田和利、山下弘高、木村万里子
- Organizer
  第74回日本栄養・食糧学会大会(仙台) Web開催
- Data Source
  KAKENHI-PROJECT-16K00834
[Presentation] 食物アレルギーの即時型症状に対するステロイド薬の作用機序の解析2020
- Author(s)
  村田美怜、山下弘高、森翔太、松井照明、伊藤浩明、稲垣直樹、檜井栄一、田中宏幸
- Organizer
  日本薬学会第140年会（京都）Web開催
- Data Source
  KAKENHI-PROJECT-16K00834
[Presentation] 慢性アレルギー疾患に奏効する漢方薬の探究2020
- Author(s)
  山下弘高
- Organizer
  第37回和漢医薬学会学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-19K07611
[Presentation] 食物アレルギーの即時型症状に対するステロイド薬の作用機序の解析2020
- Author(s)
  村田美怜、山下弘高、森翔太、松井照明、伊藤浩明、稲垣直樹、檜井栄一、田中宏幸
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-19K07611
[Presentation] 食物アレルギーの即時型症状に対するステロイド薬の有効性の検討2019
- Author(s)
  森翔太、山下弘高、松井照明、伊藤浩明、田中宏幸、稲垣直樹
- Organizer
  第135回日本薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-19K07611
[Presentation] 経皮感作によるマウス食物アレルギーモデルの作製と機序の解析2019
- Author(s)
  山下弘高、田中友梨、松原弘季、田中宏幸、稲垣直樹
- Organizer
  第92回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-16K00834
[Presentation] 食物アレルギーの即時型症状に対するステロイド薬の有効性の検討2019
- Author(s)
  森翔太、山下弘高、松井照明、伊藤浩明、田中宏幸、稲垣直樹
- Organizer
  第135回日本薬理学会近畿部会（岐阜）
- Data Source
  KAKENHI-PROJECT-16K00834
[Presentation] 小豆と白いんげん豆に含まれるオリゴ糖の構造特性および抗アレルギー作用2018
- Author(s)
  木村万里子、山下弘高、吉田和利、長澤治子
- Organizer
  第72回日本栄養・食糧学会大会
- Data Source
  KAKENHI-PROJECT-16K00834
[Presentation] Suppression of food allergy by maternal antigen-specific IgG in murine model.2018
- Author(s)
  Hirotaka Yamashita, Kenichi Saneyasu, Hiroyuki Tanaka, Naoki Inagaki.
- Organizer
  18th World Congress of Basic and Clinical Pharmacology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K00834
[Presentation] Structural features and prebiotic activities of water-soluble oligosaccharides obtained from Vigna and Phaseolus beans.2017
- Author(s)
  Kimura M, Yamashita H, Akamatsu M, Hotta H, Hama Y, Nagasawa H ,
- Organizer
  The 19th European Carbohydrate Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K00834
[Presentation] 食品添加物の摂取による経口免疫寛容の破綻機序の解明にむけた基礎検討2017
- Author(s)
  山下弘高、松原弘季、見尾谷昇、松井照明、田中宏幸、稲垣直樹
- Organizer
  第90回日本薬理学会年会
- Place of Presentation
  長崎ブリックホール（長崎県長崎市）
- Year and Date
  2017-03-15
- Data Source
  KAKENHI-PROJECT-16K00834
[Presentation] マウス食物アレルギーモデルの作製と食品添加物による免疫寛容獲得阻害に関する検討2017
- Author(s)
  山下弘高、田中宏幸、稲垣直樹
- Organizer
  第66回日本アレルギー学会学術大会
- Data Source
  KAKENHI-PROJECT-16K00834
[Presentation] 食品添加物が経口免疫寛容に及ぼす影響2016
- Author(s)
  松原弘季、山下弘高、見尾谷昇、松井照明、田中宏幸、稲垣直樹
- Organizer
  第６５回日本アレルギー学会学術大会
- Place of Presentation
  東京国際フォーラム（東京都千代田区）
- Year and Date
  2016-06-17
- Data Source
  KAKENHI-PROJECT-16K00834
[Presentation] マウス食物アレルギーモデルの作製と経口免疫寛容の解析2011
- Author(s)
  山下弘高
- Organizer
  日本薬学会第131年会
- Place of Presentation
  (東日本大震災のため誌面開催)
- Year and Date
  2011-03-31
- Data Source
  KAKENHI-PROJECT-22790075
[Presentation] マウス食物アレルギーモデルの作製と経口免疫寛容の解析2011
- Author(s)
  山下弘高、高橋慶多、田中宏幸、永井博弌、稲垣直樹
- Organizer
  日本薬学会第131年会
- Place of Presentation
  東日本大震災のため紙面開催
- Year and Date
  2011-03-31
- Data Source
  KAKENHI-PROJECT-22790075
[Presentation] マウス食物アレルギーモデルの作製と基礎的解析2011
- Author(s)
  山下弘高
- Organizer
  第84回日本薬理学会年会
- Place of Presentation
  (東日本大震災のため誌面開催)
- Year and Date
  2011-03-22
- Data Source
  KAKENHI-PROJECT-22790075
[Presentation] マウス食物アレルギーモデルを用いた経口免疫寛容誘導機序の検討2011
- Author(s)
  高橋慶多、山下弘高、田中宏幸、永井博弌、稲垣直樹
- Organizer
  第119回日本薬理学会近畿部会
- Place of Presentation
  ウィンク愛知(名古屋)
- Year and Date
  2011-07-08
- Data Source
  KAKENHI-PROJECT-22790075
[Presentation] マウス食物アレルギーモデルの作製と基礎的解析2011
- Author(s)
  山下弘高、高橋慶多、田中宏幸、永井博弌、稲垣直樹
- Organizer
  第84回日本薬理学会年会
- Place of Presentation
  東日本大震災のため紙面開催
- Year and Date
  2011-03-22
- Data Source
  KAKENHI-PROJECT-22790075
[Presentation] マウス食物アレルギーモデルを用いた経口免疫寛容の検討2010
- Author(s)
  山下弘高
- Organizer
  第60回アレルギー学会秋季学術大会
- Place of Presentation
  東京
- Year and Date
  2010-11-27
- Data Source
  KAKENHI-PROJECT-22790075
[Presentation] マウス食物アレルギーモデルを用いた経口免疫寛容の検討2010
- Author(s)
  山下弘高、高橋慶多、田中宏幸、永井博弌、稲垣直樹
- Organizer
  第60回アレルギー学会秋季学術大会
- Place of Presentation
  東京国際フォーラム(東京)
- Year and Date
  2010-11-27
- Data Source
  KAKENHI-PROJECT-22790075

1. Kimura Mariko (00351932)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
2. 前田恵 (20434988)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
3. 吉田和利 (40470249)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. 藤田裕之 (70523819)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. TOYOHIRA Yumiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

YAMASHITA Hirotaka 山下 弘高

Yamashita Hirotaka 山下 弘高

Research Projects

Research Products

Co-Researchers

新規食品素材「アクアファバ」に含まれる遊離型オリゴ糖・ペプチドの構造と機能解析

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

"Allergy via Intestine" and "Allergy via Skin"Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Structural and functional analyses of bioactive oligosaccharides in kidney beans.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The approach for therapy of food allergy to use mouse modelPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Oral allergy induction through skin exposure to previously tolerated food antigens in murine models2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Prophylactic steroid use is ineffective in food allergy: A randomized‐controlled clinical trial and a murine model2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Spontaneous pulmonary emphysema in mice lacking all three nitric oxide synthase isoforms2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Impact of orally-administered oligosaccharides in a murine model of food allergy2021

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Staphylococcal Phage in Combination with Staphylococcus epidermidis as a Potential Treatment for Staphylococcus aureus-Associated Atopic Dermatitis and Suppressor of Phage-Resistant Mutants2020

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Convenient preparation of an antigenic oligosaccharide from white kidney bean powder: A useful plant oligosaccharide for synthesis of immunoactive glycopolymer.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Food allergy is linked to season of birth, sun exposure, and vitamin D deficiency2019

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] 特集2 経口免疫寛容 経口免疫寛容の誘導における食品添加物の影響2019

Author(s)

Journal Title

Data Source

[Journal Article] Immune suppression of food allergy by maternal IgG in murine models2018

Author(s)

Journal Title

DOI

ISSN

Language

Data Source

YAMASHITA Hirotaka 山下弘高

Yamashita Hirotaka 山下弘高

[Journal Article] 特集2　経口免疫寛容経口免疫寛容の誘導における食品添加物の影響2019