NOGUCHI Tohru 野口徹

Researcher Number	40456421
Affiliation (based on the past Project Information) *help	2012 – 2014: 金沢大学, 医学系, 助教 2013: 金沢大学, 医薬保健学総合研究科, 特任助教 2011: 金沢大学, 医学系・研究科, 助教 2011: 金沢大学, 医学系研究科, 特任助教 2009 – 2010: 金沢大学, 医学系研究科, 助教 2008 – 2009: Kanazawa University, 医学系研究科, 特任助教
Review Section/Research Field	Principal Investigator Metabolomics Except Principal Investigator Metabolomics / Circulatory organs internal medicine
Keywords	Principal Investigator LDLR / FH / apoB-100 / 遺伝子大規模欠失・重複変異 / インベーダーアッセイ法 / PCSK9 / apo-B-100 / MLPA法 / LDL受容体 / 家族性高コレステロール血症 … More Except Principal Investigator … More 家族性高コレステロール血症 / PCSK9 / 脂質代謝異常 / 遺伝子多型 / LDL受容体 / LDLコレステロール / 胆汁酸受容体 / コレステロールエステル転送蛋白 / 残余リスク / コレステリルエステル転送蛋白 / リポ蛋白代謝 / 高比重リポ蛋白 / 常染色体劣性高コレステロール血症 / 安定同位体 Less

Impact of novel causal gene mutation of familial hypercholesterolemia on its clinical features and prognosis
- Principal Investigator
  
  KAWASHIRI MASAAKI
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Kanazawa University
High-density lipoprotein composition and development of coronary artery disease
- Principal Investigator
  
  NOHARA Atsushi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Kanazawa University
Systematic Analysis of Pathophysiology of Familial Hypercholesterolemia Due to Different Causal Gene Mutations
- Principal Investigator
  
  KAWASHIRI Masaaki
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Kanazawa University
Analysis of the genetic backgrounds of familial hypercholesterolemia to achieve the effective therapy.Principal Investigator
- Principal Investigator
  
  NOGUCHI Tohru
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Metabolomics
- Research Institution
  Kanazawa University

All 2014 2013 2012 2011 2010 2009 2008

All Journal Article Presentation

[Journal Article] Genotypic and phenotypic features in homozygous familial hypercholesterolemia caused by proprotein convertase subtilisin/kexin type 9 (PCSK9) gain-of-function mutation2014
- Author(s)
  Mabuchi H, Nohara A, Noguchi T, Kobayashi J, Kawashiri MA, Inoue T, Mori M, Tada H, Nakanishi C, Yagi K, Yamagishi M, Ueda K, Takegoshi T, Miyamoto S, Inazu A, Koizumi J; The Hokuriku FH Study Group
- Journal Title
  
  Atherosclerosis
  
  Volume: 236 Issue: 1 Pages: 54-61
- DOI
  10.1016/j.atherosclerosis.2014.06.005
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23590663, KAKENHI-PROJECT-24591041, KAKENHI-PROJECT-26461359
[Journal Article] Efficacy and safety of coadministration of rosuvastatin, ezetimibe, and colestimide in heterozygous familial hypercholesterolemia2012
- Author(s)
  Kawashiri MA, Nohara A, Noguchi T, Tada H, Nakanishi C, Mori M, Konno T, Hayashi K, Fujino N, Inazu A, Kobayashi J, Mabuchi H, Yamagishi M
- Journal Title
  
  Am J Cardiol
  
  Volume: 109 Issue: 3 Pages: 364-9
- DOI
  10.1016/j.amjcard.2011.09.019
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591160, KAKENHI-PROJECT-22590808, KAKENHI-PROJECT-23590663, KAKENHI-PROJECT-23591334
[Journal Article] Novel mutations of cholesteryl ester transfer protein(CETP) gene in Japanese hyperalphalipoproteinemic subjects2012
- Author(s)
  Ohtani R, Inazu A, Noji Y, Wakasugi T, Miwa K, Tada H, Kawashiri MA, Noguchi T, Nohara A, Kobayashi J, Koizumi J, Yamagishi M, Mabuchi H
- Journal Title
  
  Clin Chim Acta
  
  Volume: 413 Issue: 5-6 Pages: 537-43
- DOI
  10.1016/j.cca.2011.11.010
- NAID
  120004026116
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591160, KAKENHI-PROJECT-23590663, KAKENHI-PROJECT-23591334
[Journal Article] Altered metabolism of low-density lipoprotein and very-low-density lipoprotein remnant in autosomal recessive hypercholesterolemia : results from stable isotope kinetic study in vivo2012
- Author(s)
  Tada H, Kawashiri MA, Ikewaki K, Terao Y, Noguchi T, Nakanishi C, Tsuchida M, Takata M, Miwa K, Konno T, Hayashi K, Nohara A, Inazu A, Kobayashi J, Mabuchi H, Yamagishi M
- Journal Title
  
  Circ Cardiovasc Genet
  
  Volume: 5 Issue: 1 Pages: 35-41
- DOI
  10.1161/circgenetics.111.960948
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591160, KAKENHI-PROJECT-23590663, KAKENHI-PROJECT-23591334
[Journal Article] Post-prandial remnant lipoprotein metabolism in autosomal recessive hypercholesterolaemia2012
- Author(s)
  Tada H
- Journal Title
  
  Eur J Clin Invest
  
  Volume: 42 Issue: 10 Pages: 1094-1099
- DOI
  10.1111/j.1365-2362.2012.02700.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590517, KAKENHI-PROJECT-23590663, KAKENHI-PROJECT-23591334, KAKENHI-PROJECT-24790748
[Journal Article] Comparison of effects of bezafibrate and fenofibrate on circulating proprotein convertase subtilisin/kexin type 9 and adipocytokine levels in dyslipidemic subjects with impaired glucose tolerance or type 2 diabetes mellitus : results from a crossover study2011
- Author(s)
  Noguchi T, et al., 計14名、9番目
- Journal Title
  
  Atherosclerosis
  
  Volume: 217 Issue: 1 Pages: 165-170
- DOI
  10.1016/j.atherosclerosis.2011.02.012
- NAID
  120003141452
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591160, KAKENHI-PROJECT-22590772, KAKENHI-PROJECT-23590663, KAKENHI-PROJECT-23591334
[Journal Article] Hokuriku FH Study Group. Molecular genetic epidemiology of homozygous familial hypercholesterolemia in the Hokuriku district of Japan2011
- Author(s)
  Mabuchi H, Nohara A, Noguchi T, Kobayashi J, Kawashiri MA, Tada H, Nakanishi C, Mori M, Yamagishi M, Inazu A, Koizumi J
- Journal Title
  
  Atherosclerosis
  
  Volume: 214 Issue: 2 Pages: 404-407
- DOI
  10.1016/j.atherosclerosis.2010.11.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590761, KAKENHI-PROJECT-21591160, KAKENHI-PROJECT-23590663
[Journal Article] Impact of bezafibrate and atorvastatin on lipoprotein subclass in patients with type III hyperlipoproteinemia : result from a crossover study2011
- Author(s)
  Kawashiri MA, Kobayashi J, Nohara A, Noguchi T, Tada H, Nakanishi C, Inazu A, Mabuchi H, Yamagishi M
- Journal Title
  
  Clin Chim Acta
  
  Volume: 412 Issue: 11-12 Pages: 1068-75
- DOI
  10.1016/j.cca.2011.02.026
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591160, KAKENHI-PROJECT-23590663
[Journal Article] A novel type of familial hypercholesterolemia : double heterozygous mutations in LDL receptor and LDL receptor adaptor protein 1 gene2011
- Author(s)
  Tada H, Kawashiri MA, Ohtani R, Noguchi T, Nakanishi C, Konno T, Hayashi K, Nohara A, Inazu A, Kobayashi J, Mabuchi H, Yamagishi M
- Journal Title
  
  Atherosclerosis
  
  Volume: 219 Issue: 2 Pages: 663-6
- DOI
  10.1016/j.atherosclerosis.2011.08.004
- NAID
  120003368152
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591160, KAKENHI-PROJECT-23590663, KAKENHI-PROJECT-23591334, KAKENHI-PROJECT-24591041
[Journal Article] The E32K variant of PCSK9 exacerbates the phenotype of familial hypercholesterolaemia by increasing PCSK9 function and concentration in the circulation2010
- Author(s)
  Noguchi T, Katsuda S, Kawashiri MA, Tada H, Nohara A, Inazu A, Yamagishi M, Kobayashi J, Mabuchi H
- Journal Title
  
  Atherosclerosis
  
  Volume: 210 Issue: 1 Pages: 166-72
- DOI
  10.1016/j.atherosclerosis.2009.11.018
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591160
[Journal Article] The E32K variant of PCSK9 exacerbates the phenotype of familial hypercholesterolaemia by increasing PCSK9 function and concentration in the circulation2010
- Author(s)
  Noguchi, T., Katsuda, S., Kawashiri, MA., T ada, H., Nohara, A., Inazu, A., Yamagishi, M., Kobayashi, J., Mabuchi, H.
- Journal Title
  
  Atherosclerosis 210
  
  Pages: 166-172
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790642
[Journal Article] The E32K variant of PCSK9 exacerbates the phenotype of familial hypercholesterolaemia by increasing PCSK9 function and concentration in the circulation2010
- Author(s)
  Noguchi.T
- Journal Title
  
  Atherosclerosis (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790642
[Journal Article] The E32K variant of PCSK9 exacerbates the phenotype of familial hype rcholesterolaemia by increasing PCSK9 function and concentration in the circulation.2010
- Author(s)
  Noguchi T, et al.(計9名、3番目)
- Journal Title
  
  Atherosclerosis.
  
  Volume: 210 Pages: 166-172
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591160
[Journal Article] Formation of prebeta1-HDL during lipolysis of triglyceride-rich lipoprotein2009
- Author(s)
  Miyazaki O, Fukamachi I, Mori A, Hashimoto H, Kawashiri MA, Nohara A, Noguchi T, Inazu A, Yamagishi M, Mabuchi H, Kobayashi J
- Journal Title
  
  BiochemBiophys Res Commun
  
  Volume: 379 Issue: 1 Pages: 55-9
- DOI
  10.1016/j.bbrc.2008.11.146
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591160
[Presentation] Usefulness of FH Gene Test in Patients with Dyslipidemia2013
- Author(s)
  Nohara A, Ohtani R, Noguchi T, Inoue T, Mori M, Nakanishi C, Kawashiri MA, Yagi K, Inazu A, Yamagishi M, Mabuchi H
- Organizer
  第45回日本動脈硬化学会総会・学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23591334
[Presentation] PCSK9: A Marker of Responsiveness to Statin and Atheerosclerosis2013
- Author(s)
  Masa-aki Kawashiri, Tohru Noguchi, Mutsuko Takata, Atsushi Nohara, Akihiro Inazu, Hiroaki Hattori, Hiroshi Mabuchi, Masakazu Yamagishi
- Organizer
  第77回日本循環器学会学術集会
- Place of Presentation
  パシフィコ横浜（神奈川県）
- Invited
- Data Source
  KAKENHI-PROJECT-24591041
[Presentation] Common PCSK9 E32K Variant as Genetic Background of Familial Combined Hyperlipidemia2013
- Author(s)
  Nohara A, Noguchi T, Inoue T, Mori M, Nakanishi C, Kawashiri MA, Yagi K, Inazu A, Yamagishi M, Mabuchi H
- Organizer
  The 81st European Atherosclerosis Society Congress
- Place of Presentation
  Lyon, France
- Data Source
  KAKENHI-PROJECT-23591334
[Presentation] Common PCSK9 E32K Variant as Genetic Background of Familial Combined Hyperlipidemia2013
- Author(s)
  Nohara A, Noguchi T, Inoue T, Mori M, Nakanishi C, Kawashiri MA, Yagi K, Inazu A, Yamagishi M, Mabuchi H
- Organizer
  第77回日本循環器学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23591334
[Presentation] Common PCSK9 E32K Variant as Genetic Background of Familial Combined Hyperlipidemia.2013
- Author(s)
  Nohara A, Noguchi T, Inoue T, Mori M, Nakanishi C, Kawashiri MA, Yagi K, Inazu A, Yamagishi M, Mabuchi H.
- Organizer
  The 81st European Atherosclerosis Society Congress
- Place of Presentation
  Lyon, France
- Data Source
  KAKENHI-PROJECT-23591334
[Presentation] Usefulness of FH Gene Test in Patients with Dyslipidemia.2013
- Author(s)
  Nohara A, Ohtani R, Noguchi T, Inoue T, Mori M, Nakanishi C, Kawashiri MA, Yagi K, Inazu A, Yamagishi M, Mabuchi H.
- Organizer
  第45回日本動脈硬化学会総会・学術集会
- Place of Presentation
  東京・京王プラザ
- Data Source
  KAKENHI-PROJECT-23591334
[Presentation] Triglyceride-Rich High-Density Lipoprotein Composition as Residual Risk Biomarker of Coronary Artery Disease Including Reduced eGFR and Pre-diabetes.2012
- Author(s)
  Nohara A, Inazu A, Noguchi T, Tada H, Mori M, Nakanishi C, Kawashiri MA, Yagi K, Kobayashi J, Yamagishi M, Mabuchi H.
- Organizer
  American Heart Association's Scientific Sessions, 2012
- Place of Presentation
  Los Angeles Convention Center, Los Angeles (USA)
- Data Source
  KAKENHI-PROJECT-23591334
[Presentation] Impact of ER-Stress Affecting Variant of XBP-1 Gene on Lipids, Diabetes, Chronic Kidney Disease, and Coronary Artery Disease.2012
- Author(s)
  Nohara A, Noguchi T, Tada H, Mori M, Nakanishi C, Kawashiri MA, Yagi K, Inazu A, Kobayashi J, Yamagishi M, Mabuchi H.
- Organizer
  American Heart Association's Scientific Sessions, 2012
- Place of Presentation
  Los Angeles Convention Center, Los Angeles (USA)
- Data Source
  KAKENHI-PROJECT-23591334
[Presentation] Hypertriglyceridemia eliminates positive correlations of plasma CETP with LDL-C and with Lp(a)2012
- Author(s)
  Nohara A, Noguchi T, Tada H, Mori M, Nakanishi C, Kawashiri M, Yagi K, Inazu A, Kobayashi J, Yamagishi M, Mabuchi H
- Organizer
  XVI International Symposium on Atherosclerosis
- Place of Presentation
  Sydney Convention and Exhibition Centre (Australia)
- Data Source
  KAKENHI-PROJECT-23591334
[Presentation] Statin Therapy Improves Fractional Catabolic Rate of LDL without Affecting Impaired VLDL and VLDL Remnant Catabolism in Homozygous FH Patient Due to PCSK9 Gene Mutation: Evidence from Kinetic Study with Stable Isotope2012
- Author(s)
  Masa-aki Kawashiri, Katsunori Ikewaki, Hayato Tada, Tohru Noguchi, Atsushi Nohara, Akihiro Inazu, Junji Kobayashi, Hiroshi Mabuchi, Masakazu Yamagishi
- Organizer
  The 85th American Heart Association 2012 Scientific Sessions
- Place of Presentation
  Los Angeles Convention Center (USA)
- Data Source
  KAKENHI-PROJECT-24591041
[Presentation] Impact of ER-Stress Affecting Variant of XBP-1 Gene on Lipids, Diabetes, Chronic Kidney Disease, and Coronary Artery Disease2012
- Author(s)
  Nohara A, Noguchi T, Tada H, Mori M, Nakanishi C, Kawashiri MA, Yagi K, Inazu A, Kobayashi J, Yamagishi M, Mabuchi H
- Organizer
  American Heart Association's Scientific Sessions, 2012
- Place of Presentation
  Los Angeles (USA)
- Data Source
  KAKENHI-PROJECT-23591334
[Presentation] Extreme Contrast of Atherosclerosis in Coronary and Carotid Artery in Patients with Lipoprotein-lipase Deficiency due to Different Gene Mutation2012
- Author(s)
  川尻剛照、小林淳二、多田隼人、野口徹、野原淳、稲津明広、馬渕宏、山岸正和
- Organizer
  第44回日本動脈硬化学会総会・学術集会
- Place of Presentation
  ヒルトン福岡シーホーク（福岡県）
- Data Source
  KAKENHI-PROJECT-24591041
[Presentation] Triglyceride-Rich High-Density Lipoprotein Composition as Residual Risk Biomarker of Coronary Artery Disease Including Reduced eGFR and Pre-diabetes2012
- Author(s)
  Nohara A, Inazu A, Noguchi T, Tada H, Mori M, Nakanishi C, Kawashiri MA, Yagi K, Kobayashi J, Yamagishi M, Mabuchi H
- Organizer
  American Heart Association's Scientific Sessions
- Place of Presentation
  Los Angeles (USA)
- Data Source
  KAKENHI-PROJECT-23591334
[Presentation] Hypertriglyceridemia eliminates positive correlations of plasma CETP with LDL-C and with Lp(a)2012
- Author(s)
  Nohara A, Noguchi T, Tada H, Mori M, Nakanishi C, Kawashiri MA, Yagi K, Inazu A, Kobayashi J, Yamagishi M, Mabuchi H
- Organizer
  XVI International Symposium on Atherosclerosis 2012
- Place of Presentation
  Sydney, AUS
- Data Source
  KAKENHI-PROJECT-23591334
[Presentation] Impact of “Isolated” and “Non-isolated” Low Levels of HDL-C2012
- Author(s)
  Nohara A, Noguchi T, Tada H, Mori M, Nakanishi C, Kawashiri MA, Yagi K, Inazu A, Kobayashi J, Yamagishi M, Mabuchi H.
- Organizer
  第44回日本動脈硬化学会総会・学術集会
- Place of Presentation
  ヒルトン福岡シーホーク，福岡県
- Data Source
  KAKENHI-PROJECT-23591334
[Presentation] Normalizing Pre-β1-HDL Levels with Eicosapentaenoic Acid Add-on to Atorvastatin2012
- Author(s)
  Nohara A, Kobayashi J, Noguchi T, Tada H, Mori M, Nakanishi C, Kawashiri M, Yagi K, Inazu A, Yamagishi M, Mabuchi H
- Organizer
  第76回日本循環器学会総会・学術集会
- Place of Presentation
  福岡国際会議場(福岡)
- Data Source
  KAKENHI-PROJECT-23591334
[Presentation] HDL-C Was Negatively Associated with Achilles' Tendon Thickening among Genetically Confirmed Familial Hypercholesterolemia2012
- Author(s)
  Nohara A, Noguchi T, Tada H, Mori M, Nakanishi C, Kawashiri MA, Yagi K, Inazu A, Kobayashi J, Yamagishi M, Mabuchi H
- Organizer
  HDL Satellite Symposium 2012
- Place of Presentation
  Cairns, AUS
- Data Source
  KAKENHI-PROJECT-23591334
[Presentation] シンポジウム・心血管疾患予防のための新しいバイオマーカーImpact of Triglyceride-Rich High-Density Lipoprotein Composition as a New Marker for Development of Angiographic Coronary Artery Disease2011
- Author(s)
  Nohara A, Inazu A, Noguchi T, Tada H, Mori M, Nakanishi C, Kawashiri M, Yagi K, Kobayashi J, Yamagishi M, Mabuchi H
- Organizer
  第75回日本循環器学会総会・学術集会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23591334
[Presentation] et al. Impact of impaired LDL catabolism and increased VLDL and VLDL remnant production on hypercholesterolemia in homozygous PCSK9 mutation : Evidence from a kinetic study with stable isotope2011
- Author(s)
  Masaaki Kawashiri, Katsunori Ikewaki, Tohru Noguchi
- Organizer
  84^<th> American Heart Association 2011 Scientific Sessions
- Place of Presentation
  Orange County Convention Center, Orlando, USA
- Data Source
  KAKENHI-PROJECT-21591160
[Presentation] Impact of elevated PCSK9 levels on regulation of LDL-cholesterol after statin treatment : Study with different types of lipid lowering drugs2011
- Author(s)
  川尻剛照,野口徹, ほか
- Organizer
  第75回日本循環器学会総会・学術集会
- Place of Presentation
  パシフィコ横浜(横浜、神奈川県)
- Data Source
  KAKENHI-PROJECT-21591160
[Presentation] Impact of elevated PCSK9 levels on regulation of LDL-cholesterol after statin treatment : Study with different typesof lipid lowering drugs2011
- Author(s)
  Masaaki Kawashiri, Katsunori Ikewaki, Tohru Noguchi, et al
- Organizer
  60^<th> Annual Scientific Session of American College of Cardiology
- Place of Presentation
  Ernest N. Morial Convention Center, New Orleans,(USA)
- Data Source
  KAKENHI-PROJECT-21591160
[Presentation] シンポジウム・我が国に於ける家族性高コレステロール血症我が国に於けるFHの疫学とCHDへのリスク2011
- Author(s)
  野原淳,野口徹,小林淳二,多田隼人,森三佳,中西千明,川尻剛照,八木邦公,稲津明広,山岸正和,馬渕宏
- Organizer
  第43回日本動脈硬化学会総会・学術集会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23591334
[Presentation] Impaired LDL catabolism and increased VLDL and VLDL remnant production in homozygous familial hypercholesterolemia with PCSK9 gene mutation2011
- Author(s)
  川尻剛照,池脇克則,野口徹, ほか
- Organizer
  第75回日本循環器学会総会・学術集会
- Place of Presentation
  パシフィコ横浜(横浜、神奈川県)
- Data Source
  KAKENHI-PROJECT-21591160
[Presentation] "Intra-Individual Variability" of Fasting Lipids in Primary Hyperlipidemia is Associated With Fatty Liver, Hyperapobetalipoproteinemia and Advanced Coronary Artery Disease, But Not With Insulin Resistance2011
- Author(s)
  Nohara A, Yagi K, Noguchi T, Tada H, Mori M, Nakanishi C, Kawashiri M, Inazu A, Kobayashi J, Yamagishi M, Mabuchi H
- Organizer
  American Diabetes Association 71st Scientific Sessions
- Place of Presentation
  San Diego Convention Center (USA)
- Data Source
  KAKENHI-PROJECT-23591334
[Presentation] シンポジウム・心血管疾患予防のための新しいバイオマーカー　Impact of Triglyceride-Rich High-Density Lipoprotein Composition as a New Marker for Development of Angiographic Coronary Artery Disease2011
- Author(s)
  Nohara A, Inazu A, Noguchi T, Tada H, Mori M, Nakanishi C, Kawashiri M, Yagi K, Kobayashi J, Yamagishi M, Mabuchi H
- Organizer
  第75回日本循環器学会総会・学術集会
- Place of Presentation
  パシフィコ横浜(横浜)
- Data Source
  KAKENHI-PROJECT-23591334
[Presentation] Common E32K mutation in the PCSK9 gene exacerbates the phenotype of familial hypercholesterolaemia despite moderate increase in plasma PCSK9 and LDL-C levels perse2010
- Author(s)
  Tohru Noguchi
- Organizer
  PCSK9 Conference
- Place of Presentation
  Chambre de commerce et d'industrie de Nantes (France)
- Year and Date
  2010-03-11
- Data Source
  KAKENHI-PROJECT-20790642
[Presentation] Impact of the LDL-receptor-related molecules on the achievement of optimal LDL cholesterol level : Evidence from newly identified gene mutations2010
- Author(s)
  川尻剛照, 多田隼人, 中西千明, 山岸正和, 野口徹, 野原淳, 小林淳二, 馬渕宏, 池脇克則
- Organizer
  第74回日本循環器学会総会・学術集会シンポジウム
- Place of Presentation
  グランドプリンスホテル京都 (京都府)
- Year and Date
  2010-03-05
- Data Source
  KAKENHI-PROJECT-21591160
[Presentation] Common E32K mutation in the PCSK9 gene exacerbates the phenotype of familial hypercholesterolaemia despite moderate increase in plasma PCSK9 and LDL-C levels per se2010
- Author(s)
  Noguchi, T.
- Organizer
  CSK9 Conference
- Place of Presentation
  Chambre de commerce et d'industrie de Nantes (France)
- Year and Date
  2010-03-11
- Data Source
  KAKENHI-PROJECT-20790642
[Presentation] Elevation of PCSK9 levels after statin therapy : study with different types of lipid lowering drugs2010
- Author(s)
  川尻剛照,野口徹, ほか
- Organizer
  第43回日本動脈硬化学会総会・学術集会
- Place of Presentation
  ロイトン札幌(札幌、北海道)
- Data Source
  KAKENHI-PROJECT-21591160
[Presentation] Profiles of gain-of-function PCSK9 E32K mutation: including pure homozygote and compound heterozygote with LDLR gene mutation2009
- Author(s)
  Noguchi, T.
- Organizer
  XV International Symposium on Atherosclerosis
- Place of Presentation
  John B. Hynes Convention Center (USA)
- Year and Date
  2009-06-16
- Data Source
  KAKENHI-PROJECT-20790642
[Presentation] Profiles of gain-of-function PCSK9 E32K mutation : including pure homozygote and compound heterozygote with LDLR gene mutation2009
- Author(s)
  Tohru Noguchi
- Organizer
  XV International Symposium on Atherosclerosis
- Place of Presentation
  John B.Hynes Convention Center (USA)
- Year and Date
  2009-06-16
- Data Source
  KAKENHI-PROJECT-20790642
[Presentation] Effects of PCSK9 E32K and LDLR mutations on circulating PCSK9 levels2009
- Author(s)
  野口徹
- Organizer
  第41回日本動脈硬化学会総会
- Place of Presentation
  海峡メッセ下関(山口県)
- Year and Date
  2009-07-17
- Data Source
  KAKENHI-PROJECT-20790642
[Presentation] PCSK9遺伝子E32K変異と家族性高コレステロール血症2008
- Author(s)
  野口徹
- Organizer
  第40回日本動脈硬化学会総会
- Place of Presentation
  つくば国際会議場(茨城県)
- Year and Date
  2008-07-11
- Data Source
  KAKENHI-PROJECT-20790642
[Presentation] PCSK9遺伝子E32K変異と家族性高コレステロール血症2008
- Author(s)
  野口徹
- Organizer
  第40回日本動脈硬化学会総会
- Place of Presentation
  つくば
- Year and Date
  2008-07-11
- Data Source
  KAKENHI-PROJECT-20790642

1. KAWASHIRI Masaaki (90345637)

# of Collaborated Projects: 2 results

# of Collaborated Products: 16 results
2. IKEWAKI Katsunori (40287199)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
3. NOHARA Atsushi (50313648)

# of Collaborated Projects: 1 results

# of Collaborated Products: 18 results
4. KOBAYASHI Junji (60302577)

# of Collaborated Projects: 1 results

# of Collaborated Products: 14 results
5. INAZU Akihiro (80293348)

# of Collaborated Projects: 1 results

# of Collaborated Products: 18 results
6. YAGI Kunimasa (30293343)

# of Collaborated Projects: 1 results

# of Collaborated Products: 18 results
7. KOIZUMI Junji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

NOGUCHI Tohru 野口 徹

Research Projects

Research Products

Co-Researchers

Impact of novel causal gene mutation of familial hypercholesterolemia on its clinical features and prognosis

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High-density lipoprotein composition and development of coronary artery disease

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Systematic Analysis of Pathophysiology of Familial Hypercholesterolemia Due to Different Causal Gene Mutations

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Analysis of the genetic backgrounds of familial hypercholesterolemia to achieve the effective therapy.Principal Investigator

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[Journal Article] Genotypic and phenotypic features in homozygous familial hypercholesterolemia caused by proprotein convertase subtilisin/kexin type 9 (PCSK9) gain-of-function mutation2014

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[Journal Article] Efficacy and safety of coadministration of rosuvastatin, ezetimibe, and colestimide in heterozygous familial hypercholesterolemia2012

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[Journal Article] Novel mutations of cholesteryl ester transfer protein(CETP) gene in Japanese hyperalphalipoproteinemic subjects2012

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NAID

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[Journal Article] Altered metabolism of low-density lipoprotein and very-low-density lipoprotein remnant in autosomal recessive hypercholesterolemia : results from stable isotope kinetic study in vivo2012

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[Journal Article] Post-prandial remnant lipoprotein metabolism in autosomal recessive hypercholesterolaemia2012

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[Journal Article] Comparison of effects of bezafibrate and fenofibrate on circulating proprotein convertase subtilisin/kexin type 9 and adipocytokine levels in dyslipidemic subjects with impaired glucose tolerance or type 2 diabetes mellitus : results from a crossover study2011

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NAID

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[Journal Article] Hokuriku FH Study Group. Molecular genetic epidemiology of homozygous familial hypercholesterolemia in the Hokuriku district of Japan2011

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[Journal Article] Impact of bezafibrate and atorvastatin on lipoprotein subclass in patients with type III hyperlipoproteinemia : result from a crossover study2011

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[Journal Article] A novel type of familial hypercholesterolemia : double heterozygous mutations in LDL receptor and LDL receptor adaptor protein 1 gene2011

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NAID

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[Journal Article] The E32K variant of PCSK9 exacerbates the phenotype of familial hypercholesterolaemia by increasing PCSK9 function and concentration in the circulation2010

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NOGUCHI Tohru 野口徹