Iijima Osamu 飯島修

Researcher Number	40466206
Affiliation (based on the past Project Information) *help	2013 – 2015: 日本医科大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Pediatrics
Keywords	Principal Investigator アルカリフォスファターゼ / 低フォスファターゼ症 / アルカリホスファターゼ / レンチウイルスベクター / 骨格筋芽細胞 / 造血幹細胞 / 骨髄幹細胞 / 低ホスファターゼ症 / 遺伝子治療 / 再生・細胞医療

Development of regenerative medicine and cell therapy for inherited metabolic diseases using hypophosphatasia micePrincipal Investigator
- Principal Investigator
  
  Iijima Osamu
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Nippon Medical School

All 2016 2015 2013 Other

All Journal Article Presentation

[Journal Article] Treatment of hypophosphatasia by muscle-directed expression of bone-targeted alkaline phosphatase via self-complementary AAV8 vector.2016
- Author(s)
  Nakamura-Takahashi,A., Miyake,K., Watanabe, A., Hirai, Y., Iijima, O., Miyake, N., Adachi K.,, Nitahara-Kasahara, Y., Kinoshita, H., Noguchi, T., Abe, S., Narisawa, S., Millán, J. L., Shimada, T.,Okada, T.
- Journal Title
  
  Molecular Therapy- Methods & Clinical Development
  
  Volume: 3 Pages: 15059-15059
- DOI
  10.1038/mtm.2015.59
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25460407, KAKENHI-PROJECT-25461564, KAKENHI-PROJECT-26293328
[Journal Article] Prevention of Lethal Murine Hypophosphatasia by Neonatal Ex Vivo Gene Therapy Using Lentivirally Transduced Bone Marrow Cells.2015
- Author(s)
  Iijima O, Miyake K, Watanabe A, Miyake N, Igarashi T, Kanokoda C, Nakamura-Takahashi A, Kinoshita H, Noguchi T, Abe S, Narisawa S, Millán JL, Okada T, Shimada T.
- Journal Title
  
  Hum Gene Ther.
  
  Volume: 26 Issue: 12 Pages: 801-12
- DOI
  10.1089/hum.2015.078
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09604, KAKENHI-PROJECT-26461596, KAKENHI-PROJECT-25461564
[Presentation] Prolonged Survival and Improved Phenotypes of Lethal Hypophosphatasia Model Mice By Adeno-Associated Virus Mediated Muscle Transduction of Bone-Targeted Alkaline Phosphatase.2015
- Author(s)
  Nakamura A, Miyake K, Watanabe A, Hirai Y, Miyake N, Iijima O, Adachi K, Kinoshita H, Noguchi T, Abe S, Shimada T, Okada T.
- Organizer
  18th American Society of Gene and Cell Therapy Annual Meeting
- Place of Presentation
  Hyatt Regency New Orleans（New Orleans, LA）
- Year and Date
  2015-05-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461564
[Presentation] Gene therapy to rescue lethal hypophosphatasia model mice by adeno-associated virus-mediated muscle transduction of bone-targeted alkaline phosphatase.2015
- Author(s)
  Nakamura A, Miyake K, Watanabe A, Hirai Y, Iijima O, Miyake N, Adachi K, Nitahara-Kasahara Y, Kinoshita H, Noguchi T, Abe S, Narisawa S, Millan JL, Shimada T, Okada T.
- Organizer
  第21回日本遺伝子治療学会学術集会
- Place of Presentation
  大阪国際会議場（大阪府）
- Year and Date
  2015-07-23
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461564
[Presentation] Long-term enzyme replacement therapy for hypophosphatasia by muscle-directed expression of bone targeted alkaline phosphatase using self-complementary AAV8 vector.2015
- Author(s)
  Nakamura-Takahashi A, Miyake K, Watanabe A, Hirai Y, Iijima O, Miyake N, Adachi K, Nitahara-Kasahara Y, Kinoshita H, Noguchi T, Abe S, Narisawa S, Millan JL, Shimada T, Okada T.
- Organizer
  第11回ALPS研究会
- Place of Presentation
  日本女子大学（東京都）
- Year and Date
  2015-07-18
- Data Source
  KAKENHI-PROJECT-25461564
[Presentation] Rescue of lethal murine hypophosphatasia using genetically modified bone marrow cells expressing bone-targeted tissue non-specific alkaline phosphatase.2015
- Author(s)
  Iijima O, Miyake K, Watanabe A, Miyake N, Igarashi T, Kanokoda C, Nakamura-Takahashi A, Kinoshita H, Noguchi T, Abe S, Narisawa S, Millan JL, Okada T, Shimada T.
- Organizer
  第11回ALPS研究会
- Place of Presentation
  日本女子大学（東京都）
- Year and Date
  2015-07-18
- Data Source
  KAKENHI-PROJECT-25461564
[Presentation] 低フォスファターゼ症マウスに対するex vivo遺伝子治療法の検討2013
- Author(s)
  飯島　修、三宅弘一、中村有希、鹿子田千津、五十嵐勉、渡邉　淳、島田　隆
- Organizer
  第58回日本人類遺伝学会
- Place of Presentation
  江陽グランドホテル（宮城県仙台市）
- Data Source
  KAKENHI-PROJECT-25461564
[Presentation] Bone marrow cell based enzyme replacement prolongs survival and improves disease phenotypes in a mouse model of lethal hypophosphatasia2013
- Author(s)
  Iijima O, Miyake K, Nakamura A, Igarashi T, Kanokoda C, Watanabe A, Shimada T
- Organizer
  55th American Society of Hematology Annual Meeting and Exposition
- Place of Presentation
  Ernest N. Morial Convention Center (New Orleans, LA, USA)
- Data Source
  KAKENHI-PROJECT-25461564
[Presentation] Gene Therapy Improves Dental Manifestations in Akp2-/- Hypophosphatasia Mice.
- Author(s)
  Okawa R, Iijima O, Kishino M, Okawa H, Toyosawa S, Shimada T, Okada T, Ooshima T, Nakano K.
- Organizer
  International Association for Dental Research General Session (93th)
- Place of Presentation
  Hynes Convention Center (Boston, MA)
- Year and Date
  2015-03-11 – 2015-03-14
- Data Source
  KAKENHI-PROJECT-25461564
[Presentation] Neonatal transplantation of lentivirally transduced bone marrow cells for the treatment of lethal hypophosphatasia mice.
- Author(s)
  Iijima O, Miyake K, Watanabe A, Nakamura A, Igarashi T, Kanokoda C, Kinoshita H, Noguchi T, Abe S, Okada T, Shimada T.
- Organizer
  日本遺伝子治療学会学術集会（第20回）
- Place of Presentation
  東京慈恵会医科大学（東京都）
- Year and Date
  2014-08-06 – 2014-08-08
- Data Source
  KAKENHI-PROJECT-25461564
[Presentation] Rescue of lethal hypophosphatasia model mice by adeno-associated virus mediated muscle specific expression of bone targeted alkaline phosphatase.
- Author(s)
  Nakamura A, Iijima O, Miyake K, Watanabe A, Hirai Y, Kinoshita H, Noguchi T, Abe S, Okada T, Shimada T.
- Organizer
  American Society of Human Genetics Annual Meeting (64th)
- Place of Presentation
  San Diego Convention Center（San Diego, CA）
- Year and Date
  2014-10-18 – 2014-10-22
- Data Source
  KAKENHI-PROJECT-25461564
[Presentation] Improvement of hypophosphatasia model mice by muscle specific expression of bone targeted alkaline phosphatase using self-complementary AAV8 vector.
- Author(s)
  Nakamura A, Iijima O, Miyake K, Watanabe A, Hirai Y, Kinoshita H, Noguchi T, Abe S, Okada T, Shimada T.
- Organizer
  日本遺伝子治療学会学術集会（第20回）
- Place of Presentation
  東京慈恵会医科大学（東京都）
- Year and Date
  2014-08-06 – 2014-08-08
- Data Source
  KAKENHI-PROJECT-25461564

1. MIYAKE Koichi (90267211)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
2. SHIMADA Takashi (20125074)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
3. WATANABE Atsushi (10307952)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
4. 平井幸彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 三宅紀子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Iijima Osamu 飯島 修

Research Projects

Research Products

Co-Researchers

Development of regenerative medicine and cell therapy for inherited metabolic diseases using hypophosphatasia micePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Treatment of hypophosphatasia by muscle-directed expression of bone-targeted alkaline phosphatase via self-complementary AAV8 vector.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Prevention of Lethal Murine Hypophosphatasia by Neonatal Ex Vivo Gene Therapy Using Lentivirally Transduced Bone Marrow Cells.2015

Author(s)

Journal Title

DOI

Data Source

[Presentation] Prolonged Survival and Improved Phenotypes of Lethal Hypophosphatasia Model Mice By Adeno-Associated Virus Mediated Muscle Transduction of Bone-Targeted Alkaline Phosphatase.2015

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Gene therapy to rescue lethal hypophosphatasia model mice by adeno-associated virus-mediated muscle transduction of bone-targeted alkaline phosphatase.2015

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Long-term enzyme replacement therapy for hypophosphatasia by muscle-directed expression of bone targeted alkaline phosphatase using self-complementary AAV8 vector.2015

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Rescue of lethal murine hypophosphatasia using genetically modified bone marrow cells expressing bone-targeted tissue non-specific alkaline phosphatase.2015

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] 低フォスファターゼ症マウスに対するex vivo遺伝子治療法の検討2013

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] Bone marrow cell based enzyme replacement prolongs survival and improves disease phenotypes in a mouse model of lethal hypophosphatasia2013

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] Gene Therapy Improves Dental Manifestations in Akp2-/- Hypophosphatasia Mice.

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Neonatal transplantation of lentivirally transduced bone marrow cells for the treatment of lethal hypophosphatasia mice.

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Rescue of lethal hypophosphatasia model mice by adeno-associated virus mediated muscle specific expression of bone targeted alkaline phosphatase.

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Improvement of hypophosphatasia model mice by muscle specific expression of bone targeted alkaline phosphatase using self-complementary AAV8 vector.

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

Iijima Osamu 飯島修