HARA Chikako 原央子

Researcher Number	40528452
Other IDs	https://orcid.org/0009-0009-4326-232X
Affiliation (based on the past Project Information) *help	2012 – 2019: 東京慈恵会医科大学, 医学部, 助教 2010 – 2011: 東京医科歯科大学, 大学院・保健衛生学研究科, 助教
Review Section/Research Field	Principal Investigator Basic Section 51030:Pathophysiologic neuroscience-related / Neurochemistry/Neuropharmacology / Neurophysiology and muscle physiology Except Principal Investigator Otorhinolaryngology / Neuroscience in general
Keywords	Principal Investigator 神経変性 / 細胞内凝集体 / VPS35 / α-シヌクレイン / パーキンソン病 / レトロマー / 筋委縮性側索硬化症 / モデルマウス / 細胞内凝集体形成 / 神経変性疾患 … More / FTLD / ALS / 前頭側頭変性症 / 筋萎縮性側索硬化症 / プローブ開発 / ルシフェラーゼ / イメージング / フェリチン / 発光 / 蛍光 / in vivoイメージング / MRI / in vivo イメージング / 発光イメージング / イメージング技術開発 / 神経再生 / 神経発生 … More Except Principal Investigator CRISPR/ Cas9 / コンディショナルノックアウト / ＣＲＩＳＰＲ／Ｃａｓ９ / CRIPR/Cas9 / コンディショナルノックアウトマウス / 先天性難聴 / RNA結合タンパク質 / TDP-43 / ALS Less

凝集体形成を指標としたエンドソーム・レトロマー動態多次元解析による神経病態研究Principal Investigator
- Principal Investigator
  
  原央子
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Jikei University School of Medicine
Development of a Versatile Method for Producing Inner-Ear-Specific Knockout Mice
- Principal Investigator
  
  Sakurai Yuika
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Jikei University School of Medicine
Investigation of the role of neuronal cell deth in a neurodegenerative prosess of ALS model micePrincipal Investigator
- Principal Investigator
  
  Hara Chikako
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Jikei University School of Medicine
Analyses of regulatory mechanisms of TDP-43 level and risk factor of ALS
- Principal Investigator
  
  OKANO Hirotaka James
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neuroscience in general
- Research Institution
  Jikei University School of Medicine
Development ofa new probe for dynamic imaging of transplanted cells without surgical operation.Principal Investigator
- Principal Investigator
  
  HARA Chikako
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurophysiology and muscle physiology
- Research Institution
  Jikei University School of Medicine
  Tokyo Medical and Dental University

All 2015 2014 2013 2012 2011 Other

All Journal Article Presentation

[Journal Article] Analysis of RNA metabolism in peripheral WBCs of TDP-43 KI mice identifies novel biomarkers of ALS.2015
- Author(s)
  Hasegawa M., Hara-Miyauchi C., Ohta H., Sakimura K., Okano H., Okano H. J.
- Journal Title
  
  Neuroscience Research
  
  Volume: 106 Pages: 12-22
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25870754
[Journal Article] Bioluminescent system for dynamic imaging of cell and animal behavior2012
- Author(s)
  Hara-Miyauchi C., Tsuji O., Hanyu A., Okada S, Yasuda A., Fukano T., Akazawa C., Nakamura M., Imamura T., Matsuzaki Y., Okano H.J., Miyawaki A., Okano H.
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 419 Pages: 188-193
- Data Source
  KAKENHI-PROJECT-22700417
[Journal Article] Bioluminescent system for dynamic imaging of cell and animal behavior2012
- Author(s)
  Hara-Miyauchi C, Tsuji O, Hanyu A, Okada S, Yasuda A, Fukano T, Akazawa C, Nakamura M, Imamura T, Matsuzaki Y, Okano HJ, Miyawaki A, Okano H
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 419(2) Issue: 2 Pages: 188-93
- DOI
  10.1016/j.bbrc.2012.01.141
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390062, KAKENHI-PROJECT-22390292, KAKENHI-PROJECT-22700417, KAKENHI-PROJECT-23650327
[Journal Article] Host-derived MMP-13 exhibits a protective role in lung metastasis of melanoma cells by local endostatin production.2011
- Author(s)
  Fukuda H., Mochizuki S., Abe H., Okano H.J., Hara-Miyauchi C., Okano H., Yamaguchi N., Nakayama M., D'Armiento J., Okada Y.
- Journal Title
  
  British Journal of Cancer.
  
  Volume: 105 Pages: 1615-1624
- Data Source
  KAKENHI-PROJECT-22700417
[Journal Article] Comparative Study of Methods for Administering Neural Stem/Progenitor Cells to Treat Spinal Cord Injury in Mice2011
- Author(s)
  Takahashi Y., Tsuji O., Kumagai G., Hara M. C., Okano J. H., Miyawaki A., Toyama Y., Okano H., Nakamura M.
- Journal Title
  
  Cell Transplantation.
  
  Volume: 20 Pages: 727-739
- Data Source
  KAKENHI-PROJECT-22700417
[Presentation] TAR DNA binding protein-43(TDP-43)に変異を持つ筋萎縮性側索硬化症および前頭側頭変性症の動物モデル2014
- Author(s)
  Chikako Hara-Miyauchi
- Organizer
  成体脳ニューロン新生懇談会
- Place of Presentation
  東京大学フューチャーセンター（千葉県柏市）
- Year and Date
  2014-12-05
- Data Source
  KAKENHI-PROJECT-25870754
[Presentation] 生細胞発光イメージングの in vivo 解析への応用2013
- Author(s)
  原央子
- Organizer
  生理学東京談話会
- Place of Presentation
  タワーホール船橋
- Year and Date
  2013-03-26
- Data Source
  KAKENHI-PROJECT-22700417
[Presentation] Multimodal and exclusive pathology between ALS and FTLD by TDP-43 mutations
- Author(s)
  Chikako Hara-Miyauchi
- Organizer
  Society for Neuroscience
- Place of Presentation
  ワシントンD.C.
- Year and Date
  2014-11-16 – 2014-11-20
- Data Source
  KAKENHI-PROJECT-25870754
[Presentation] 生細胞発光イメージングの in vivo 解析への応用
- Author(s)
  原　央子
- Organizer
  生理学東京談話会
- Place of Presentation
  タワーホール船橋
- Data Source
  KAKENHI-PROJECT-22700417
[Presentation] Development of biomarkers in peripheral blood cells of ALS model mice.
- Author(s)
  Hasegawa M, Hara-Miyauchi C, Okano HJ
- Organizer
  米国神経科学会
- Place of Presentation
  Walter E Washington Convention Center, Washington D. C. U.S.A.
- Year and Date
  2014-11-15 – 2014-11-19
- Data Source
  KAKENHI-PROJECT-24300122
[Presentation] Multimodal and exclusive pathology between ALS and FTLD caused by TDP-43 mutations
- Author(s)
  Hara-Miyauchi C, Date Y, Hasegawa M, Kobayashi R, Fujigasaki J, Kogo N, Sano C, Kobayashi Y, Suzuki N, Itohara S, Okano H, Okano HJ
- Organizer
  米国神経科学会
- Place of Presentation
  Walter E Washington Convention Center, Washington D. C. U.S.A.
- Year and Date
  2014-11-15 – 2014-11-19
- Data Source
  KAKENHI-PROJECT-24300122
[Presentation] Multimodal and exclusive pathology between ALS and FTLD by TDP-43 mutations
- Author(s)
  Chikako Hara-Miyauchi
- Organizer
  日本神経科学会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-09-11 – 2014-09-13
- Data Source
  KAKENHI-PROJECT-25870754

1. OKANO Hirotaka James (90338020)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
2. Sakurai Yuika (50307427)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. Kojima Hiromi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. Udagawa Tomokatsu

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. Kurihara Sho

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 松崎有未

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HARA Chikako 原 央子

Research Projects

Research Products

Co-Researchers

凝集体形成を指標としたエンドソーム・レトロマー動態多次元解析による神経病態研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a Versatile Method for Producing Inner-Ear-Specific Knockout Mice

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Investigation of the role of neuronal cell deth in a neurodegenerative prosess of ALS model micePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analyses of regulatory mechanisms of TDP-43 level and risk factor of ALS

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development ofa new probe for dynamic imaging of transplanted cells without surgical operation.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Analysis of RNA metabolism in peripheral WBCs of TDP-43 KI mice identifies novel biomarkers of ALS.2015

Author(s)

Journal Title

Data Source

[Journal Article] Bioluminescent system for dynamic imaging of cell and animal behavior2012

Author(s)

Journal Title

Data Source

[Journal Article] Bioluminescent system for dynamic imaging of cell and animal behavior2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Host-derived MMP-13 exhibits a protective role in lung metastasis of melanoma cells by local endostatin production.2011

Author(s)

Journal Title

Data Source

[Journal Article] Comparative Study of Methods for Administering Neural Stem/Progenitor Cells to Treat Spinal Cord Injury in Mice2011

Author(s)

Journal Title

Data Source

[Presentation] TAR DNA binding protein-43(TDP-43)に変異を持つ筋萎縮性側索硬化症および前頭側頭変性症の動物モデル2014

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] 生細胞発光イメージングの in vivo 解析への応用2013

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Multimodal and exclusive pathology between ALS and FTLD by TDP-43 mutations

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] 生細胞発光イメージングの in vivo 解析への応用

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] Development of biomarkers in peripheral blood cells of ALS model mice.

Author(s)

HARA Chikako 原央子