Tsutsuki Hiroyasu 津々木博康

… Alternative Names

TSUTSUKI Hiroyasu 津々木博康

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Researcher Number	40586608
Other IDs
Affiliation (Current)	2025: 熊本大学, 大学院生命科学研究部(医), 講師
Affiliation (based on the past Project Information) *help	2022 – 2023: 熊本大学, 大学院生命科学研究部(医), 講師 2017 – 2021: 熊本大学, 大学院生命科学研究部(医), 助教 2018: 熊本大学, 大学院生命科学研究部, 助教 2016: 大阪府立大学, 理学(系)研究科(研究院), 助教 2013: 大阪府立大学, 理学(系)研究科(研究院), 助教 2012: 金沢大学, 大学院・医学系研究科, 助教 2010 – 2011: 千葉大学, 大学院・医学研究院, 助教
Review Section/Research Field	Principal Investigator Basic Section 54030:Infectious disease medicine-related / Infectious disease medicine Except Principal Investigator Basic Section 37020:Chemistry and chemical methodology of biomolecules-related / Bacteriology (including Mycology) / Medium-sized Section 37:Biomolecular chemistry and related fields / Biomolecular chemistry and related fields
Keywords	Principal Investigator 細菌毒素 / 小胞体ストレス / 腸管出血性大腸菌 / Subtilase cytotoxin / 宿主免疫 / レドックス / 宿主防御機構 / インフラマソーム / 自然免疫 Except Principal Investigator システインパースルフィド … More / 活性イオウ / インフラマソーム / 自然炎症 / レドックス / 超硫黄分子 / NLRP3インフラマソーム / 酸化ストレス / 志賀毒素 / 腸管出血性大腸菌 / 毒素 / イオウ代謝 / 炎症 / 食作用 / マクロファージ / 細胞内殺菌 / 食細胞 / 安定同位体 / メタボロミクス / 自然免疫 / 活性酸素 / グルタチオン / NO / lipid-raft / 阻害剤 / 取り込み機構 / オートファジー / ｌipid-raft / ストレスグラニュール / 細胞死 / 一酸化窒素 / 小胞体ストレス / SubAB / Bcl-2 / ERストレス / BiP / サブチラーゼサイトトキシン / 受容体 / アポトーシス / ER ストレス Less

腸管出血性大腸菌毒素SubABの宿主獲得免疫破綻機構とその感染病態制御法の解明Principal Investigator
- Principal Investigator
  
  津々木博康
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54030:Infectious disease medicine-related
- Research Institution
  Kumamoto University
Molecular mechanisms of inhibitory regulation of NLRP3 inflammasome by reactive sulfur species
- Principal Investigator
  
  Sawa Tomohiro
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 37020:Chemistry and chemical methodology of biomolecules-related
- Research Institution
  Kumamoto University
Elucidation of the redox activation mechanism of enterohemorrhagic Escherichia coli toxin SubAB and the infection controlPrincipal Investigator
- Principal Investigator
  
  Tsutsuki Hiroyasu
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54030:Infectious disease medicine-related
- Research Institution
  Kumamoto University
Mechanisms of intracellular bacterial killing induced by reactive sulfur species
- Principal Investigator
  
  Sawa Tomohiro
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 37:Biomolecular chemistry and related fields
- Research Institution
  Kumamoto University
Molecular mechanisms of NLRP3 inflammasome activation via glutathione efflux
- Principal Investigator
  
  Sawa Tomohiro
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 37020:Chemistry and chemical methodology of biomolecules-related
- Research Institution
  Kumamoto University
Molecular analysis for pathogenesis of SubAB produced by Enterohemorrhagic Escherichia coli through the inhibitory effects on host innate immunityPrincipal Investigator
- Principal Investigator
  
  Tsutsuki Hiroyasu
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Infectious disease medicine
- Research Institution
  Kumamoto University
Reactive sulfur metabolomics for the study of cellular sulfur dynamics
- Principal Investigator
  
  Sawa Tomohiro
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Research Field
  
  Biomolecular chemistry and related fields
- Research Institution
  Kumamoto University
Elucidation of the pathogenic reinforcement action of enterohemorrhagic Escherichia coli produced SubAB
- Principal Investigator
  
  Noda Masatoshi
- Project Period (FY)
  2012 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Chiba University
Elucidation of Shiga-toxigenic Escherichia coli produced Subtilase cytotoxin-induced cell damage mechanism.
- Principal Investigator
  
  NODA Masatoshi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Chiba University

[Book] 生体の科学（特集タンパク質・核酸の分子修飾）2018
- Author(s)
  津々木博康、澤　智裕、居原　秀
- Total Pages
  2
- Publisher
  公益財団法人金原一郎記念医学医療振興財団/医学書院
- Data Source
  KAKENHI-PROJECT-17K10019
[Journal Article] Redox Biology Involved in the Toxicity of Enterohemorrhagic <i>Escherichia coli</i> Toxin SubAB2024
- Author(s)
  Tsutsuki Hiroyasu、Zhang Tianli、Sawa Tomohiro
- Journal Title
  
  YAKUGAKU ZASSHI
  
  Volume: 144 Issue: 1 Pages: 57-60
- DOI
  10.1248/yakushi.23-00162-4
- ISSN
  0031-6903, 1347-5231
- Year and Date
  2024-01-01
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K07942
[Journal Article] Regulation of innate immune and inflammatory responses by supersulfides2024
- Author(s)
  Tsutsuki Hiroyasu、Zhang Tianli、Akaike Takaaki、Sawa Tomohiro
- Journal Title
  
  International Immunology
  
  Volume: 36 Issue: 4 Pages: 143-154
- DOI
  10.1093/intimm/dxad057
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19397, KAKENHI-PROJECT-23K17979, KAKENHI-PROJECT-23K20040, KAKENHI-PROJECT-23K07942, KAKENHI-PLANNED-21H05263, KAKENHI-PROJECT-18H05277, KAKENHI-PLANNED-21H05267, KAKENHI-PROJECT-21H02071
[Journal Article] Alkyl gallates inhibit serine O-acetyltransferase in bacteria and enhance susceptibility of drug-resistant Gram-negative bacteria to antibiotics2023
- Author(s)
  Toyomoto Touya、Ono Katsuhiko、Shiba Tomoo、Momitani Kenta、Zhang Tianli、Tsutsuki Hiroyasu、Ishikawa Takeshi、Hoso Kanae、Hamada Koma、Rahman Azizur、Wen Liping、Maeda Yosuke、Yamamoto Keiichi、Matsuoka Masao、Hanaoka Kenjiro、Niidome Takuro、Akaike Takaaki、Sawa Tomohiro
- Journal Title
  
  Frontiers in Microbiology
  
  Volume: 14 Pages: 1276447-1276447
- DOI
  10.3389/fmicb.2023.1276447
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19397, KAKENHI-PROJECT-23K20040, KAKENHI-PROJECT-22K05443, KAKENHI-PROJECT-22K08602, KAKENHI-PROJECT-23K07942, KAKENHI-PLANNED-21H05263, KAKENHI-PROJECT-18H05277, KAKENHI-ORGANIZER-21H05258, KAKENHI-PLANNED-21H05262, KAKENHI-PLANNED-21H05267, KAKENHI-PROJECT-21H02071, KAKENHI-PROJECT-23K25210, KAKENHI-PROJECT-23K27304
[Journal Article] Modification of Silver Nanoplates with Cell-Binding Subunit of Bacterial Toxin and Their Antimicrobial Activity against Intracellular Bacteria2023
- Author(s)
  Ayaka Harada, Wei Xu, Katsuhiko Ono, Hiroyasu Tsutsuki, Kinnosuke Yahiro, Tomohiro Sawa, and Takuro Niidome
- Journal Title
  
  ACS Appl. Bio Mater.
  
  Volume: 未定 Issue: 9 Pages: 3387-3394
- DOI
  10.1021/acsabm.3c00019
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22KJ2520, KAKENHI-PROJECT-23K07942, KAKENHI-PROJECT-23K25210
[Journal Article] New insights into the regulatory roles of glutathione in NLRP3-inflammasome-mediated immune and inflammatory responses2022
- Author(s)
  Zhang Tianli、Tsutsuki Hiroyasu、Li Xiaoyan、Sawa Tomohiro
- Journal Title
  
  The Journal of Biochemistry
  
  Volume: 171 Issue: 4 Pages: 367-377
- DOI
  10.1093/jb/mvab158
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H02071, KAKENHI-PROJECT-20F20408, KAKENHI-PROJECT-20K08823
[Journal Article] Subtilase cytotoxin from Shiga-toxigenic Escherichia coli impairs the inflammasome and exacerbates enteropathogenic bacterial infection.2022
- Author(s)
  Tsutsuki Hiroyasu, Zhang Tianli, Yahiro Kinnosuke, Ono Katsuhiko, Fujiwara Yukio, Iyoda Sunao, Wei Fan-Yan, Monde Kazuaki, Seto Kazuko, Ohnishi Makoto, Oshiumi Hiroyuki, Akaike Takaaki, Sawa Tomohiro.
- Journal Title
  
  iScience
  
  Volume: 25 Issue: 4 Pages: 104050-104050
- DOI
  10.1016/j.isci.2022.104050
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21496, KAKENHI-PLANNED-21H05263, KAKENHI-PROJECT-18H05277, KAKENHI-PROJECT-19H03480, KAKENHI-PROJECT-20F20408, KAKENHI-PROJECT-20K07506, KAKENHI-PROJECT-20K08823, KAKENHI-PROJECT-22K05443, KAKENHI-PROJECT-22K19397, KAKENHI-PROJECT-17H06170
[Journal Article] Non-canonical inflammasome activation analysis in a mouse model of Citrobacter rodentium infection2022
- Author(s)
  Tsutsuki Hiroyasu、Zhang Tianli、Yahiro Kinnosuke、Toyomoto Touya、Sawa Tomohiro
- Journal Title
  
  STAR Protocols
  
  Volume: 3 Issue: 4 Pages: 101741-101741
- DOI
  10.1016/j.xpro.2022.101741
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H02071, KAKENHI-PROJECT-20F20408, KAKENHI-PROJECT-20K08823
[Journal Article] Controlled Delivery of an Anti-Inflammatory Toxin to Macrophages by Mutagenesis and Nanoparticle Modification.2022
- Author(s)
  Harada Ayaka, Tsutsuki Hiroyasu, Zhang Tianli, Yahiro Kinnosuke, Sawa Tomohiro, Niidome Takuro.
- Journal Title
  
  Nanomaterials
  
  Volume: 12 Issue: 13 Pages: 2161-2161
- DOI
  10.3390/nano12132161
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08823, KAKENHI-PROJECT-23K25210
[Journal Article] ATP exposure stimulates glutathione efflux as a necessary switch for NLRP3 inflammasome activation.2021
- Author(s)
  Zhang, T., Tsutsuki, H., Islam, W., Ono, K., Takeda, K., Akaike, T. and Sawa, T.
- Journal Title
  
  Redox Biology
  
  Volume: 41 Pages: 101930-101930
- DOI
  10.1016/j.redox.2021.101930
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07032, KAKENHI-PROJECT-20K08823, KAKENHI-PROJECT-20K21496, KAKENHI-PROJECT-18H02098, KAKENHI-PROJECT-20F20408, KAKENHI-PROJECT-19K22258, KAKENHI-PROJECT-17H06170, KAKENHI-PROJECT-18H05277
[Journal Article] Cysteine hydropersulfide inactivates β-lactam antibiotics to form ring opened carbothioic S-acids in bacteria.2021
- Author(s)
  Ono, K., Kitamura, Y., Zhang, T., Tsutsuki, H., Rahman, A., Akaike, T., Ihara, T., Sawa, T.
- Journal Title
  
  ACS Chem Biol.
  
  Volume: 16 Issue: 4 Pages: 731-739
- DOI
  10.1021/acschembio.1c00027
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22258, KAKENHI-PROJECT-19K22259, KAKENHI-PROJECT-20K21496, KAKENHI-PLANNED-21H05263, KAKENHI-PROJECT-18H05277, KAKENHI-PROJECT-20H02769, KAKENHI-PROJECT-17H06170
[Journal Article] 8-Nitro-cGMP modulates exocytosis in adrenal chromaffin cells2020
- Author(s)
  Tsutsuki Hiroyasu、Kasamatsu Shingo、Kunieda Kohei、Ida Tomoaki、Sawa Tomohiro、Sasakawa Nobuyuki、Akaike Takaaki、Ihara Hideshi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: in press Issue: 1 Pages: 225-230
- DOI
  10.1016/j.bbrc.2020.03.045
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08619, KAKENHI-PROJECT-17K10019, KAKENHI-PROJECT-20K07306, KAKENHI-PROJECT-19K06537, KAKENHI-PROJECT-17H06170, KAKENHI-PROJECT-18H05277
[Journal Article] Involvement of protein disulfide isomerase in subtilase cytotoxin-induced cell death in HeLa cells2020
- Author(s)
  Tsutsuki Hiroyasu、Zhang Tianli、Harada Ayaka、Rahman Azizur、Ono Katsuhiko、Yahiro Kinnosuke、Niidome Takuro、Sawa Tomohiro
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 525 Issue: 4 Pages: 1068-1073
- DOI
  10.1016/j.bbrc.2020.03.008
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10019, KAKENHI-PROJECT-19K07534, KAKENHI-PROJECT-19K22258
[Journal Article] Host response to the Subtilase cytotoxin produced by locus of enterocyte effacement (LEE)-negative Shiga-toxigenic Escherichia coli (STEC)2020
- Author(s)
  Tsutsuki, H. Ogura, K. Moss, J. Yahiro, K.
- Journal Title
  
  Microbiology and Immunology.
  
  Volume: 64 Issue: 10 Pages: 657-665
- DOI
  10.1111/1348-0421.12841
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07534, KAKENHI-PROJECT-20K08823
[Journal Article] Preparation of Biodegradable PLGA-Nanoparticles Used for pH-Sensitive Intracellular Delivery of an Anti-inflammatory Bacterial Toxin to Macrophages2020
- Author(s)
  Harada Ayaka、Tsutsuki Hiroyasu、Zhang Tianli、Lee Ruda、Yahiro Kinnosuke、Sawa Tomohiro、Niidome Takuro
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 68 Issue: 4 Pages: 363-368
- DOI
  10.1248/cpb.c19-00917
- NAID
  130007824942
- ISSN
  0009-2363, 1347-5223
- Year and Date
  2020-04-01
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22258, KAKENHI-PROJECT-17K10019, KAKENHI-PROJECT-19K07534, KAKENHI-PROJECT-18H02098
[Journal Article] Enhanced Cellular Polysulfides Negatively Regulate TLR4 Signaling and Mitigate Lethal Endotoxin Shock2019
- Author(s)
  Zhang Tianli、Ono Katsuhiko、Tsutsuki Hiroyasu、Ihara Hideshi、Islam Waliul、Akaike Takaaki、Sawa Tomohiro
- Journal Title
  
  Cell Chemical Biology
  
  Volume: in press Issue: 5 Pages: 686-698.e4
- DOI
  10.1016/j.chembiol.2019.02.003
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10019, KAKENHI-PLANNED-26111008, KAKENHI-PROJECT-18H05277, KAKENHI-PROJECT-16H04674, KAKENHI-PROJECT-17K19205, KAKENHI-PROJECT-19K22258, KAKENHI-PROJECT-17H06170, KAKENHI-PROJECT-18H02098
[Journal Article] Gold-Treated Silver Nanoparticles Have Enhanced Antimicrobial Activity2019
- Author(s)
  Harada Ayaka、Ichimaru Hiroaki、Kawagoe Takayuki、Tsushida Masayuki、Niidome Yasuro、Tsutsuki Hiroyasu、Sawa Tomohiro、Niidome Takuro
- Journal Title
  
  Bulletin of the Chemical Society of Japan
  
  Volume: 92 Issue: 2 Pages: 297-301
- DOI
  10.1246/bcsj.20180232
- NAID
  130007595735
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10019
[Journal Article] Synthesis of Pegylated Manganese Protoporphyrin as a Catalase Mimic and Its Therapeutic Application to Acetaminophen-Induced Acute Liver Failure2019
- Author(s)
  Zhang Tianli、Fang Jun、Tsutsuki Hiroyasu、Ono Katsuhiko、Islam Waliul、Sawa Tomohiro
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 42 Issue: 7 Pages: 1199-1206
- DOI
  10.1248/bpb.b19-00152
- NAID
  130007672166
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2019-07-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K22258, KAKENHI-PROJECT-17K10019, KAKENHI-PROJECT-18H02098
[Journal Article] A Simple PLGA-AgNPL Film for Antibiofilm Formation by Contact Bactericidal Activity2018
- Author(s)
  Kyaw Kaung、Motoyama Nana、Ichimaru Hiroaki、Harada Ayaka、Morimura Shigeru、Ono Katsuhiko、Tsutsuki Hiroyasu、Sawa Tomohiro、Miyazawa Yuta、Mizoguchi Daigou、Niidome Takuro
- Journal Title
  
  Chemistry Letters
  
  Volume: 47 Issue: 3 Pages: 308-310
- DOI
  10.1246/cl.171022
- NAID
  130006434041
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K19205, KAKENHI-PROJECT-15H03115
[Journal Article] Reactive Cysteine Persulphides: Occurrence, Biosynthesis, Antioxidant Activity, Methodologies, and Bacterial Persulphide Signalling2018
- Author(s)
  Sawa Tomohiro、Ono Katsuhiko、Tsutsuki Hiroyasu、Zhang Tianli、Ida Tomoaki、Nishida Motohiro、Akaike Takaaki
- Journal Title
  
  Advances in Microbial Physiology
  
  Volume: 72 Pages: 1-28
- DOI
  10.1016/bs.ampbs.2018.01.002
- ISBN
  9780128144138
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08619, KAKENHI-PROJECT-17K10019, KAKENHI-PROJECT-18H02098, KAKENHI-PROJECT-16KT0013, KAKENHI-PROJECT-17K19205, KAKENHI-PROJECT-18H05293
[Journal Article] Mechanism of inhibition of Shiga-toxigenic Escherichia coli SubAB cytotoxicity by steroids and diacylglycerol analogues2018
- Author(s)
  Yahiro Kinnosuke、Nagasawa Sayaka、Ichimura Kimitoshi、Takeuchi Hiroki、Ogura Kohei、Tsutsuki Hiroyasu、Shimizu Takeshi、Iyoda Sunao、Ohnishi Makoto、Iwase Hirotaro、Moss Joel、Noda Masatoshi
- Journal Title
  
  Cell Death Discovery
  
  Volume: 4 Issue: 1 Pages: 22-22
- DOI
  10.1038/s41420-017-0007-4
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08486, KAKENHI-PROJECT-16K08770, KAKENHI-PROJECT-17K10019, KAKENHI-PROJECT-18K07133, KAKENHI-PROJECT-16K08771
[Journal Article] Reactive Persulfides from Salmonella Typhimurium Downregulate Autophagy-Mediated Innate Immunity in Macrophages by Inhibiting Electrophilic Signaling2018
- Author(s)
  Khan Shahzada、Fujii Shigemoto、Matsunaga Tetsuro、Nishimura Akira、Ono Katsuhiko、Ida Tomoaki、Ahmed Khandaker Ahtesham、Okamoto Tatsuya、Tsutsuki Hiroyasu、Sawa Tomohiro、Akaike Takaaki
- Journal Title
  
  Cell Chemical Biology
  
  Volume: 25 Issue: 11 Pages: 1403-1413
- DOI
  10.1016/j.chembiol.2018.08.007
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08619, KAKENHI-PROJECT-17K10019, KAKENHI-PROJECT-18K07099, KAKENHI-PLANNED-26111008, KAKENHI-PROJECT-18H05277, KAKENHI-PROJECT-18H02098, KAKENHI-PROJECT-17K19205, KAKENHI-PROJECT-17K15408, KAKENHI-PROJECT-17H06170
[Journal Article] Gold Coating of Silver Nanoplates for Enhanced Dispersion Stability and Efficient Antimicrobial Activity against Intracellular Bacteria2018
- Author(s)
  Ichimaru Hiroaki、Harada Ayaka、Yoshimoto Soichiro、Miyazawa Yuta、Mizoguchi Daigou、Kyaw Kaung、Ono Katsuhiko、Tsutsuki Hiroyasu、Sawa Tomohiro、Niidome Takuro
- Journal Title
  
  Langmuir
  
  Volume: 34 Issue: 35 Pages: 10413-10418
- DOI
  10.1021/acs.langmuir.8b00540
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10019
[Journal Article] Involvement of nitric oxide/reactive oxygen species signaling via 8-nitro-cGMP formation in 1-methyl-4-phenylpyridinium ion-induced neurotoxicity in PC12 cells and rat cerebellar granule neurons2018
- Author(s)
  Masuda Kumiko、Tsutsuki Hiroyasu、Kasamatsu Shingo、Ida Tomoaki、Takata Tsuyoshi、Sugiura Kikuya、Nishida Motohiro、Watanabe Yasuo、Sawa Tomohiro、Akaike Takaaki、Ihara Hideshi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 495 Issue: 3 Pages: 2165-2170
- DOI
  10.1016/j.bbrc.2017.12.088
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K19205, KAKENHI-PROJECT-17K17583, KAKENHI-PLANNED-26111008, KAKENHI-PLANNED-26111011, KAKENHI-PROJECT-25220103, KAKENHI-PROJECT-15H03115, KAKENHI-PROJECT-16H04674, KAKENHI-PROJECT-16H05044, KAKENHI-PROJECT-16K13089, KAKENHI-PROJECT-16K15208, KAKENHI-PROJECT-15K20855, KAKENHI-PROJECT-15K20876, KAKENHI-PROJECT-17K08619, KAKENHI-PROJECT-16H05092, KAKENHI-PROJECT-16KT0013, KAKENHI-PROJECT-18H05293
[Journal Article] Exposure to Electrophiles Impairs Reactive Persulfide-Dependent Redox Signaling in Neuronal Cells2017
- Author(s)
  Ihara Hideshi、Kasamatsu Shingo、Kitamura Atsushi、Nishimura Akira、Tsutsuki Hiroyasu、Ida Tomoaki、Ishizaki Kento、Toyama Takashi、Yoshida Eiko、Abdul Hamid Hisyam、Jung Minkyung、Matsunaga Tetsuro、Fujii Shigemoto、Sawa Tomohiro、Nishida Motohiro、Kumagai Yoshito、Akaike Takaaki
- Journal Title
  
  Chem. Res. Toxicol
  
  Volume: 30 Issue: 9 Pages: 1673-1684
- DOI
  10.1021/acs.chemrestox.7b00120
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16KT0013, KAKENHI-PROJECT-17K08619, KAKENHI-PROJECT-17K19205, KAKENHI-PROJECT-17K15408, KAKENHI-PROJECT-17K15488, KAKENHI-PROJECT-17K17583, KAKENHI-PLANNED-26111008, KAKENHI-PLANNED-26111011, KAKENHI-PROJECT-25220103, KAKENHI-PROJECT-15H03115, KAKENHI-PROJECT-16H04674, KAKENHI-PROJECT-15K08456, KAKENHI-PROJECT-16K13089, KAKENHI-PROJECT-16K15208, KAKENHI-PROJECT-15K20855, KAKENHI-PROJECT-15K20857, KAKENHI-PROJECT-15K20876, KAKENHI-PROJECT-16H05092
[Journal Article] Subtilase cytotoxin produced by locus of enterocyte effacement-negative Shiga-toxigenic Escherichia coli induces stress granule formation2016
- Author(s)
  H. Tsutsuki, K. Yahiro, K. Ogura, K. Ichimura, S. Iyoda, M. Ohnishi, S. Nagasawa, K. Nagasawa, J. Moss, M. Noda
- Journal Title
  
  Cellular Microbiology
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390104
[Journal Article] DAP1, a Negative Regulator of Autophagy, Controls SubAB-Mediated Apoptosis and Autophagy2014
- Author(s)
  Yahiro, K. Tsutsuki, H. Ogura, K. Nagasawa, S. Moss, J. Noda, M.
- Journal Title
  
  Infect Immun
  
  Volume: 82 Issue: 11 Pages: 4899-4908
- DOI
  10.1128/iai.02213-14
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24390104
[Journal Article] Uptake of Shiga-toxigenic Escherichia coli SubAB by HeLa cells requires an actin- and lipid raft-dependent pathway2014
- Author(s)
  Nagasawa, S. Ogura, K. Tsutsuki, H. Saitoh, H. Moss, J. Iwase, H. Noda, M. Yahiro, K.
- Journal Title
  
  Cell Microbiol
  
  Volume: 16 Issue: 10 Pages: 1582-1601
- DOI
  10.1111/cmi.12315
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24390104
[Journal Article] Regulation of Subtilase cytotoxin (SubAB)-induced cell death by a PKR-like endoplasmic reticulum kinase (PERK)-dependent proteasome pathway in HeLa cells2012
- Author(s)
  Yahiro, K.Tsutsuki, H.Ogura, K.Nagasawa, S.Moss, J.Noda, M.
- Journal Title
  
  Infect Immun
  
  Volume: (In press) Issue: 5 Pages: 1803-1814
- DOI
  10.1128/iai.06164-11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390127
[Journal Article] Subtilase cytotoxin enhances Escherichia coli survival in macrophages by suppression of nitric oxide production through the inhibition of NF-κB activation2012
- Author(s)
  Tsutsuki H, Yahiro K, Suzuki K, Suto A, Ogura K, Nagasawa S, Ihara H, Shimizu T, Nakajima H, Moss J, Noda M
- Journal Title
  
  Infect Immun
  
  Volume: 80 Issue: 11 Pages: 3939-51
- DOI
  10.1128/iai.00581-12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591432, KAKENHI-PROJECT-23591458, KAKENHI-PROJECT-24390104
[Journal Article] The nitric oxide reductase of enterohemorrhagic Escherichia coli plays an important role for the survival within macrophages2012
- Author(s)
  Shimizu T, Tsutsuki H, Matsumoto A, Nakaya H, Noda M
- Journal Title
  
  Mol Microbiol
  
  Volume: 85 Issue: 3 Pages: 492-512
- DOI
  10.1111/j.1365-2958.2012.08122.x
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20117008, KAKENHI-PROJECT-23390053, KAKENHI-PROJECT-24390104, KAKENHI-PROJECT-24659111
[Journal Article] Regulation of Subtilase cytotoxin (SubAB)-induced cell death by a PKR-like endoplasmic reticulum kinase (PERK)-dependent proteasome pathway in HeLa cells2012
- Author(s)
  Yahiro, K., H. Tsutsuki, K. Ogura, S. Nagasawa, J. Moss, M. Noda
- Journal Title
  
  Infect Immun. In press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390127
[Journal Article] Moss, and M. Noda. 2011. Identification of Subtilase cytotoxin (SubAB) receptors whose signaling, in association with SubAB-induced BiP cleavage, is responsible for apoptosis in HeLa cells2011
- Author(s)
  Yahiro, K., M. Satoh, N. Morinaga, H. Tsutsuki, K. Ogura, S. Nagasawa, F. Nomura, J
- Journal Title
  
  Infect Immun
  
  Volume: 79 Pages: 617-627
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390127
[Journal Article] Characterization of Cholix toxin-induced apoptosis in HeLa cells2011
- Author(s)
  Ogura K, Yahiro K, Tsutsuki H, Nagasawa S, Yamasaki S, Moss J, Noda M
- Journal Title
  
  J Biol Chem
  
  Volume: 286 Issue: 43 Pages: 37207-15
- DOI
  10.1074/jbc.m111.246504
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390127, KAKENHI-PROJECT-22790401
[Journal Article] Identification of subtilase cytotoxin (SubAB) receptors whose signaling, in association with SubAB-induced BiP cleavage, is responsible for apoptosis in HeLa cells.2011
- Author(s)
  Yahiro K., Satoh M., Morinaga N., Tsutsuki H., Ogura K., Nagasawa S., Nomura F., Moss J., Noda M.
- Journal Title
  
  Infect Immun.
  
  Volume: 79 Pages: 617-27
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390127
[Journal Article] Characterization of cholix toxin-induced apoptosis in hela cells
- Author(s)
  Ogura, K., K. Yahiro, H. Tsutsuki, S. Nagasawa, S. Yamasaki, J. Moss, M. Noda
- Journal Title
  
  J Biol Chem
  
  Volume: 286 Pages: 37207-37215
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390127
[Patent] -酸化窒素を探知するための形質転換用組換えベクター、およびこれを用いた一酸化窒素センサ細胞2011
- Inventor(s)
  清水健, 津々木博康, 野田公俊
- Industrial Property Rights Holder
  国立大学法人, 千葉大学
- Industrial Property Number
  2011-101623
- Filing Date
  2011-04-28
- Data Source
  KAKENHI-PROJECT-21390127
[Presentation] 腸管出血性大腸菌毒素SubABの毒性発現に関与する宿主因子の解析2024
- Author(s)
  津々木博康、張田力、八尋錦之助、赤池孝章、澤智裕
- Organizer
  第23回分子予防環境医学研究会
- Data Source
  KAKENHI-PROJECT-23K07942
[Presentation] 腸管出血性大腸菌毒素SubABの毒性発現に関わる宿主レドックス因子2023
- Author(s)
  津々木博康、張田力、八尋錦之助、赤池孝章、澤智裕
- Organizer
  第34回日本生体防御学会学術総会
- Data Source
  KAKENHI-PROJECT-23K07942
[Presentation] 志賀毒素産生性大腸菌毒素SubABの病原性に関わるレドックスバイオロジー2023
- Author(s)
  津々木博康、張田力、八尋錦之助、赤池孝章、澤智裕
- Organizer
  第69回トキシンシンポジウム
- Data Source
  KAKENHI-PROJECT-23K07942
[Presentation] 志賀毒素産生性大腸菌毒素SubABの毒性に関わる宿主レドックス調節機構の解明2023
- Author(s)
  津々木　博康, 張　田力, 八尋錦之助、赤池　孝章, 澤　智裕
- Organizer
  第96回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-20K08823
[Presentation] Inhibitory mechanisms of enterohemorrhagic Escherichia coli toxin SubAB by nitric oxide2023
- Author(s)
  Hiroyasu Tsutsuki, Tianli Zhang, Takaaki Akaike, Tomohiro Sawa
- Organizer
  Nitric Oxide Gordon Research Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08823
[Presentation] 腸管出血性大腸菌毒素SubABの毒性発現に関与する宿主レドックス調節の解析2023
- Author(s)
  津々木　博康, 張　田力, 八尋錦之助、赤池　孝章, 澤　智裕
- Organizer
  第22回分子予防環境医学研究会大会
- Data Source
  KAKENHI-PROJECT-20K08823
[Presentation] 腸管出血性大腸菌毒素SubABの病原性に関わる宿主酸化還元調節の解析2023
- Author(s)
  津々木博康、張田力、八尋錦之助、赤池孝章、澤智裕
- Organizer
  九州微生物研究フォーラム2023
- Data Source
  KAKENHI-PROJECT-23K07942
[Presentation] 腸管出血性大腸菌毒素SubABの毒性発現に対する一酸化窒素の阻害機構2023
- Author(s)
  津々木博康, 張田力, 八尋錦之助、赤池孝章, 澤智裕
- Organizer
  第76回日本酸化ストレス学会学術集会
- Data Source
  KAKENHI-PROJECT-23K07942
[Presentation] 腸管出血性大腸菌毒素SubABの毒性発現に関わるレドックス調節機構2022
- Author(s)
  津々木　博康, 張　田力, 八尋錦之助、赤池　孝章, 澤　智裕
- Organizer
  第75回日本酸化ストレス学会学術集会
- Data Source
  KAKENHI-PROJECT-20K08823
[Presentation] 宿主防御機構に及ぼす志賀毒素産生性大腸菌毒素subtilase cytotoxinの影響2022
- Author(s)
  津々木博康、八尋錦之助、赤池　孝章、澤智裕
- Organizer
  第95回日本細菌学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-20K08823
[Presentation] 志賀毒素産生性大腸菌毒素SubA、Bの毒性発現に関わるレドックス調節機構2022
- Author(s)
  津々木　博康, 張　田力, 八尋錦之助、赤池　孝章, 澤　智裕
- Organizer
  第68回トキシンシンポジウム
- Data Source
  KAKENHI-PROJECT-20K08823
[Presentation] 腸管出血性大腸菌毒素SubABの毒性に関わる宿主レドックス調節機構2022
- Author(s)
  津々木　博康, 張　田力, 八尋錦之助、赤池　孝章, 澤　智裕
- Organizer
  第33回日本生体防御学会学術総会
- Data Source
  KAKENHI-PROJECT-20K08823
[Presentation] 腸管出血性大腸菌毒素Subtilase cytotoxinの毒性発現に対する活性窒素種の阻害機構2022
- Author(s)
  津々木博康、張田力、八尋錦之助、赤池孝章、澤智裕
- Organizer
  第21回分子予防環境医学研究会大会
- Data Source
  KAKENHI-PROJECT-20K08823
[Presentation] Protein S-sulfhydration based regulation of NLRP3 inflammasome2022
- Author(s)
  Tianli Zhang, Hiroyasu Tsutsuki, Motohiro Nishida, Takaaki Akaike, Tomohiro Sawa
- Organizer
  Gordon Research Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02071
[Presentation] Host redox regulatory mechanisms involved in the pathogenicity of enterohemorrhagic Escherichia coli toxin SubAB2022
- Author(s)
  Hiroyasu Tsutsuki, Tianli Zhang, Kinnosuke Yahiro, Takaaki Akaike, Tomohiro Sawa
- Organizer
  The 12th International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide. REDOX WEEK in SENDAI 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08823
[Presentation] 腸管出血性大腸菌毒素Subtilase cytotoxinに対する活性窒素種の阻害作用2021
- Author(s)
  津々木博康、張田力、八尋錦之助、小野勝彦、赤池孝章、澤智裕
- Organizer
  第74回日本酸化ストレス学会　第21回日本NO学会合同学術集会
- Data Source
  KAKENHI-PROJECT-20K08823
[Presentation] 志賀毒素産生性大腸菌毒素Subtilase cytotoxinに対する活性窒素種の作用機序の解明2021
- Author(s)
  津々木博康、張田力、八尋錦之助、小野勝彦、赤池孝章、澤智裕
- Organizer
  第67回トキシンシンポジウム
- Data Source
  KAKENHI-PROJECT-20K08823
[Presentation] 一酸化窒素による腸管出血性大腸菌毒素Subtilase cytotoxinの阻害機構の解析2021
- Author(s)
  津々木博康、張田力、八尋錦之助、小野勝彦、赤池孝章、澤智裕
- Organizer
  第94回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-20K08823
[Presentation] 活性窒素種による腸管出血性大腸菌毒素subtilase cytotoxin阻害機構の解析2021
- Author(s)
  津々木博康、張田力、八尋錦之助、赤池孝章、澤智裕
- Organizer
  第32回日本生体防御学会学術総会
- Data Source
  KAKENHI-PROJECT-20K08823
[Presentation] 腸管出血性大腸菌毒素Subtilase cytotoxinの毒性に及ぼす活性窒素種の影響2021
- Author(s)
  津々木博康、張田力、八尋錦之助、赤池孝章、澤智裕
- Organizer
  第20回分子予防環境医学研究会大会
- Data Source
  KAKENHI-PROJECT-20K08823
[Presentation] 腸管出血性大腸菌毒素SubABによる宿主自然免疫抑制機構2020
- Author(s)
  津々木　博康
- Organizer
  第31回日本生体防御学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-20K08823
[Presentation] 腸管出血性大腸菌毒素Subtilase cytotoxinの細胞毒性に関わるレドックス調節機構の解析2020
- Author(s)
  津々木博康、張田力、八尋錦之助、小野勝彦、赤池孝章、澤智裕
- Organizer
  第73回日本酸化ストレス学会　第20回日本NO学会合同学術集会
- Data Source
  KAKENHI-PROJECT-20K08823
[Presentation] 腸管出血性大腸菌毒素Subtilase cytotoxinの病原性発現におけるレドックス調節機構2020
- Author(s)
  津々木博康、張田力、八尋錦之助、小野勝彦、伊豫田淳、大西真、赤池孝章、澤智裕
- Organizer
  第93回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-17K10019
[Presentation] Subtilase cytotoxinによる宿主自然免疫抑制を介した病原性発現機構の解析2020
- Author(s)
  津々木博康、張田力、八尋錦之助、小野勝彦、赤池孝章、澤智裕
- Organizer
  第19回分子予防環境医学研究会
- Data Source
  KAKENHI-PROJECT-17K10019
[Presentation] 腸管出血性大腸菌毒素Subtilase cytotoxinが誘導する自然免疫抑制シグナルの解析2019
- Author(s)
  津々木博康、張田力、八尋錦之助、小野勝彦、伊豫田淳、勢戸和子、大西真、野田公俊、赤池孝章、澤智裕
- Organizer
  第92回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-17K10019
[Presentation] 腸管出血性大腸菌毒素SubABによる自然免疫抑制を介した病原性発現機構の解析2019
- Author(s)
  津々木博康、張田力、小野勝彦、八尋錦之助、居原　秀、赤池孝章、澤　智裕
- Organizer
  第19回日本NO学会
- Data Source
  KAKENHI-PROJECT-17K10019
[Presentation] N-Acetyl-L-cysteine polysulfides act as potent polysulfide donors and mitigate lethal endotoxin shock via their anti-inflammatory effects.2019
- Author(s)
  Zhang, T., Ono, K., Tsutsuki, H., Ihara, H., Islam, W., Akaike, T., Sawa, T.
- Organizer
  The 9th Biennial Meeting of Society for Free Radical Research-Asia
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02098
[Presentation] N-Acetyl-L-cysteine polysulfides act as potent polysulfide donors and mitigate lethal endotoxin shock via their anti-inflammatory effects.2019
- Author(s)
  Zhang, T., Ono, K., Tsutsuki, H., Ihara, H., Islam, W., Akaike, T., Sawa, T.
- Organizer
  The 9th Biennial Meeting of Society for Free Radical Research-Asia
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22258
[Presentation] PROTECTION OF MICE AGAINST LETHAL ENDOTOXIN SHOCK BY NOVEL PERSULFIDE DONORS BASED ON N-ACETYL-L-CYSTEINE.2018
- Author(s)
  Tsutsuki H., Zhang T., Ono K., Ihara H., Akaike T., Sawa T.
- Organizer
  10th International Conference on the Biology, Chemistry and Therapeutic Applications of Nitric Oxide.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10019
[Presentation] 腸管出血性大腸菌毒素Subtilase cytotoxinによるNLRP3インフラマソームの活性化抑制機構2018
- Author(s)
  津々木博康、張田力、八尋錦之助、小野勝彦、伊豫田淳、勢戸和子、大西真、赤池孝章、澤智裕
- Organizer
  第71回日本細菌学会九州支部総会
- Data Source
  KAKENHI-PROJECT-17K10019
[Presentation] 腸管出血性大腸菌毒素Subtilase cytotoxinによる宿主自然免疫抑制機構の解明2018
- Author(s)
  津々木博康
- Organizer
  第27回内毒素LPS研究会
- Invited
- Data Source
  KAKENHI-PROJECT-17K10019
[Presentation] ．活性イオウによる自然免疫応答の制御機構2018
- Author(s)
  澤　智裕，張　田力，津々木博康，小野勝彦
- Organizer
  第45回日本毒性学会学術集会
- Data Source
  KAKENHI-PROJECT-18H02098
[Presentation] Subtilase cytotoxin (SubAB)による宿主の自然免疫抑制機構の解析2018
- Author(s)
  津々木博康、張田力、小野勝彦、八尋錦之助、伊豫田淳、勢戸和子、大西真、赤池孝章、野田公俊、澤智裕
- Organizer
  第65回トキシンシンポジウム
- Data Source
  KAKENHI-PROJECT-17K10019
[Presentation] 活性イオウによる自然免疫応答の制御機構2018
- Author(s)
  澤　智裕，張　田力，津々木博康，小野勝彦
- Organizer
  第45回日本毒性学会学術集会
- Data Source
  KAKENHI-PROJECT-17K19205
[Presentation] マウス感染モデルを用いた腸管出血性大腸菌毒素Subtilase cytotoxinの解析2018
- Author(s)
  津々木博康、張田力、八尋錦之助、小野勝彦、伊豫田淳、勢戸和子、大西真、野田公俊、赤池孝章、澤智裕
- Organizer
  第17回分子予防環境医学研究会
- Data Source
  KAKENHI-PROJECT-17K10019
[Presentation] Functional in vivo analysis of Subtilase cytotoxin by means of murine infection model2018
- Author(s)
  津々木博康、張田力、八尋錦之助、小野勝彦、伊豫田淳、勢戸和子、大西真、野田公俊、赤池孝章、澤智裕
- Organizer
  第91回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-17K10019
[Presentation] マウス感染モデルを用いた腸管出血性大腸菌毒素Subtilase cytotoxinの機能解析2018
- Author(s)
  津々木博康、張田力、八尋錦之助、小野勝彦、伊豫田淳、勢戸和子、大西真、野田公俊、赤池孝章、澤智裕
- Organizer
  第91回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-17K10019
[Presentation] Subtilase cytotoxin (SubAB)による小胞体ストレスを介したNLRP3インフラマソーム抑制機構の解析2017
- Author(s)
  津々木博康、張　田力、小野　勝彦、八尋　錦之助、伊豫田　淳、勢戸和子、大西　真、赤池孝章、野田　公俊、澤　智裕
- Organizer
  第64回トキシンシンポジウム
- Data Source
  KAKENHI-PROJECT-17K10019
[Presentation] 腸管出血性大腸菌毒素Subtilase cytotoxinによる小胞体ストレスを介したNLRP3インフラマソームの活性化抑制機構2017
- Author(s)
  津々木　博康、張　田力、小野　勝彦、八尋　錦之助、伊豫田淳、勢戸和子、大西　真、野田　公俊、赤池孝章、澤　智裕
- Organizer
  第28回日本生体防御学会学術総会
- Data Source
  KAKENHI-PROJECT-17K10019
[Presentation] マウス感染モデルを用いた腸管出血性大腸菌毒素Subtilase cytotoxinの機能解析2017
- Author(s)
  津々木博康、張田力、八尋錦之助、小野勝彦、伊豫田淳、勢戸和子、大西真、赤池孝章、澤智裕
- Organizer
  第 70 回日本細菌学会九州支部総会
- Data Source
  KAKENHI-PROJECT-17K10019
[Presentation] 腸管出血性大腸菌が産生する毒素Subtilase cytotoxinによるNLRP3インフラマソームの活性化抑制機構2017
- Author(s)
  津々木　博康、張　田力、小野　勝彦、八尋　錦之助、伊豫田淳、勢戸和子、大西　真、野田　公俊、赤池孝章、澤　智裕
- Organizer
  第17回日本NO学会総会
- Data Source
  KAKENHI-PROJECT-17K10019
[Presentation] 腸管出血性大腸菌Subtilase cytotoxinによるインフラマーソム抑制機構の解析2016
- Author(s)
  津々木博康、ThianliZhang,小野勝彦、八尋錦之助、澤智裕、野田公俊
- Organizer
  第89回日本細菌学会
- Place of Presentation
  大阪
- Year and Date
  2016-03-23
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24390104
[Presentation] Shiga-toxigenic Escherichia coli SubAB-induced ER stress causes stress granule formation in mammalian cells2016
- Author(s)
  Yahiro, K., H. Tsutsuki, K. Ogura, S. Iyoda, K. Ichimura, T. Shimizu, M. Ohnishi, K. Seto, J. Moss, and M. Noda.
- Organizer
  Bethesda, USA
- Place of Presentation
  Bethesda, USA
- Year and Date
  2016-01-13
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24390104
[Presentation] Characterization of Shiga-toxigenic Escherichia coli Sub AB uptake pathway in HeLa cells2014
- Author(s)
  Sayaka Nagasawa, Kinnosuke Yahiro, Kohei Ogura, Hiroyasu Tsutsuki, Masatoshi Noda
- Organizer
  第87回日本細菌学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24390104
[Presentation] 腸管出血性大腸菌の産生するSubAB　の　PERKを介したアポトーシス制御機構2013
- Author(s)
  Kinnnosuke Yahiro, Hiroyasu Tsutsuki, Masatoshi Noda
- Organizer
  第60回毒素シンポジウム
- Place of Presentation
  兵庫県
- Data Source
  KAKENHI-PROJECT-24390104
[Presentation] Subtilase cytotoxin induces stress granule formation through PERK dependent pathway2013
- Author(s)
  Hiroyasu Tsutsuki, Kinnosuke Yahiro, Tohru Shimizu, Masatoshi Noda
- Organizer
  第86回日本細菌学会総会
- Place of Presentation
  幕張メッセ(千葉)
- Data Source
  KAKENHI-PROJECT-24390104
[Presentation] 腸管出血性大腸菌の産生するSubABのPERKを介したアポトーシス制御機構2012
- Author(s)
  八尋錦之助、津々木博康、小倉康平、野田公俊
- Organizer
  第59回トキシンシンポジウム
- Place of Presentation
  とかちプラザ(北海道)
- Data Source
  KAKENHI-PROJECT-24390104
[Presentation] Inhibitory effect of subtilase cytotoxin on LPS-induced nitric oxide production by macrophages.2012
- Author(s)
  Hiroyasu Tsutsuki, Kinnosuke Yahiro, Takeshi Shimizu and Masatoshi Noda
- Organizer
  THE 33rd NAITO CONFERENCE ON Oxygen Biology : Hypoxia, Oxidative Stress and Diseases.
- Place of Presentation
  シャトレーゼガトーキングダム札幌(北海道)
- Data Source
  KAKENHI-PROJECT-24390104
[Presentation] Molecular mechanism of inhibitory effect of SubAB on nitric oxide production by macrophages2012
- Author(s)
  津々木博康、八尋錦之助、清水健、野田公俊
- Organizer
  第85回日本細菌学会総会
- Place of Presentation
  長崎ブリックホール(長崎)(招待講演)
- Year and Date
  2012-03-27
- Data Source
  KAKENHI-PROJECT-21390127
[Presentation] Inhibitory effect of SubAB cytotoxin of enterohemorrhagic Escherichia coli on LPS-induced nitric oxide production by macrophages2012
- Author(s)
  Hiroyasu Tsutsuki and Masatoshi Noda
- Organizer
  2012 IEIIS in National Center of Sciences Building
- Place of Presentation
  国立情報学研究所(東京)
- Data Source
  KAKENHI-PROJECT-24390104
[Presentation] SubAB-induced apoptosis is regulated by a PERK-dependent proteasome pathway in HeLa cells2012
- Author(s)
  八尋錦之助、津々木博康、小倉康平、永澤明佳、盛永直子、野田公俊
- Organizer
  第85回日本細菌学会総会
- Place of Presentation
  長崎ブリックホール(長崎)
- Year and Date
  2012-03-27
- Data Source
  KAKENHI-PROJECT-21390127
[Presentation] Regulation of Subtilase cytotoxin (SubAB)-induced cell death by a PKR-like endoplasmic reticulum kinase (PERK)-dependent proteasome pathway in HeLa cells2012
- Author(s)
  Kinnosuke Yahiro, Hiroyasu Tsutsuki, Kohei Ogura, Sayaka Nagasawa, Takeshi Shimizu, Joel Moss, Masatoshi Noda
- Organizer
  7th US-Japan Cholera and Other Bacterial Enteric Infections Joint Panel Meeting.
- Place of Presentation
  千葉大学薬学部創立120周年記念講堂(千葉)
- Data Source
  KAKENHI-PROJECT-24390104
[Presentation] NO biosensor plasmid for investigating2012
- Author(s)
  清水健, 津々木博康, 野田公俊
- Organizer
  NO levels within macrophages during bacterial infection
- Place of Presentation
  長崎
- Year and Date
  2012-03-27
- Data Source
  KAKENHI-PROJECT-21390127
[Presentation] Subtilase cytotoxin enhances E. coli survival in macrophages by suppression of nitric oxide production through the inhibition of NF-kB activation.2012
- Author(s)
  Hiroyasu Tsutsuki, Kinnosuke Yahiro, Takeshi Shimizu, Masatoshi Noda
- Organizer
  47th US Japan Cholera and Other Bacterial Enteric Infections Joint Panel Meeting.
- Place of Presentation
  千葉大学薬学部創立120周年記念講堂(千葉)
- Data Source
  KAKENHI-PROJECT-24390104
[Presentation] Molecular mechanism of inhibitory effect of2012
- Author(s)
  津々木博康, 八尋錦之助, 清水健, 野田公俊
- Organizer
  SubAB on nitric oxide production by macrophages
- Place of Presentation
  長崎
- Year and Date
  2012-03-27
- Data Source
  KAKENHI-PROJECT-21390127
[Presentation] SubAB-induced apoptosis is regulated by a PERK-dependent proteasome pathway in HeLa cells2012
- Author(s)
  八尋錦之助, 津々木博康, 小倉康平, 永澤明佳, 盛永直子, 野田公俊
- Place of Presentation
  長崎
- Year and Date
  2012-03-27
- Data Source
  KAKENHI-PROJECT-21390127
[Presentation] 腸管出血性大腸菌の産生する志賀毒素以外の毒素2012
- Author(s)
  八尋錦之助、津々木博康、小倉康平、野田公俊
- Organizer
  第95回日本細菌学会関東支部総会
- Place of Presentation
  ホテル日航東京(東京)
- Data Source
  KAKENHI-PROJECT-24390104
[Presentation] NO biosensor plasmid for investigating NO levels within macrophages during bacterial infection2012
- Author(s)
  清水健、津々木博康、野田公俊
- Organizer
  第85回日本細菌学会総会
- Place of Presentation
  長崎ブリックホール(長崎)
- Year and Date
  2012-03-27
- Data Source
  KAKENHI-PROJECT-21390127
[Presentation] The nitric oxide reductase of enterohemorrhagic Escherichia coli 0157 : H7 increases Shiga toxin 2 production and plays an important role in its infection2011
- Author(s)
  Takeshi Shiraizu, Hiroyasu Tsutsuki, Akio Matsumoto, Haruaki Nakaya, Masatoshi Noda
- Organizer
  45^<th> US-Japan Cholera and Other Bacterial Enteric Infections Joint Panel Meeting
- Place of Presentation
  インド(招待講演)
- Data Source
  KAKENHI-PROJECT-21390127
[Presentation] Subtilase cytotoxin inhibits the production of nitric oxide from macrophage2011
- Author(s)
  津々木博康, 八尋錦之助, 清水健, 野田公俊
- Place of Presentation
  北海道
- Year and Date
  2011-09-10
- Data Source
  KAKENHI-PROJECT-21390127
[Presentation] The nitric oxide reductase of Enterohemorrahgicreductase of Enterohemorrahgic2011
- Author(s)
  清水健, 津々木博康, 野田公俊
- Organizer
  Escherichia coli plays an important role for the survival within macrophages
- Place of Presentation
  北海道
- Year and Date
  2011-09-10
- Data Source
  KAKENHI-PROJECT-21390127
[Presentation] 腸管出血性大腸菌NO reductaseは志賀毒素2の産生を増加させる2011
- Author(s)
  清水健、津々木博康、野田公俊
- Organizer
  第58回トキシンシンポジウム
- Place of Presentation
  順天堂大学(東京)(招待講演)
- Year and Date
  2011-07-06
- Data Source
  KAKENHI-PROJECT-21390127
[Presentation] 腸管出血性大腸菌 NO reductaseは志賀毒素2の産生を増加させる2011
- Author(s)
  清水健, 津々木博康, 野田公俊
- Organizer
  第58回トキシンシンポジウム
- Place of Presentation
  東京
- Year and Date
  2011-07-06
- Data Source
  KAKENHI-PROJECT-21390127
[Presentation] The nitric oxide reductase of Enterohemorrahgic Escherichia coli plays an important role for the survival within macrophages2011
- Author(s)
  清水健、津々木博康、野田公俊
- Organizer
  International Union of Microbiological Societies 2011 Congress
- Place of Presentation
  札幌コンベンションセンター(北海道)
- Year and Date
  2011-09-10
- Data Source
  KAKENHI-PROJECT-21390127
[Presentation] 腸管出血性大腸菌の産生する新規SubABトキシンによるNO産生抑制機構の解明2011
- Author(s)
  津々木博康, 八尋錦之助, 清水健, 野田公俊
- Organizer
  第58回トキシンシンポジウム
- Place of Presentation
  東京
- Year and Date
  2011-07-06
- Data Source
  KAKENHI-PROJECT-21390127
[Presentation] 腸管出血性大腸菌の産生する新規SubABトキシンによるNO産生抑制機構の解明2011
- Author(s)
  津々木博康、八尋錦之助、清水健、野田公俊
- Organizer
  第58回トキシンシンポジウム
- Place of Presentation
  順天堂大学(東京)(招待講演)
- Year and Date
  2011-07-06
- Data Source
  KAKENHI-PROJECT-21390127
[Presentation] Subtilase cytotoxin inhibits the production of nitric oxide from macrophage2011
- Author(s)
  津々木博康、八尋錦之助、清水健、野田公俊
- Organizer
  International Union of Microbiological Societies 2011 Congress
- Place of Presentation
  札幌コンベンションセンター(北海道)
- Year and Date
  2011-09-10
- Data Source
  KAKENHI-PROJECT-21390127
[Presentation] 腸管出血性大腸菌が産生するSubtilase cytotoxinはマクロファージのNO産生を抑制する2011
- Author(s)
  津々木博康, 八尋錦之助, 清水健, 野田公俊
- Organizer
  第96回日本細菌学会関東支部総会
- Place of Presentation
  東京
- Year and Date
  2011-10-06
- Data Source
  KAKENHI-PROJECT-21390127
[Presentation] 腸管出血性大腸菌の産生する新規SubABトキシンによるNO産生抑制機構の解明2010
- Author(s)
  津々木博康, 八尋錦之助, 清水健, 野田公俊
- Organizer
  インターラボセミナー
- Place of Presentation
  千葉
- Year and Date
  2010-12-11
- Data Source
  KAKENHI-PROJECT-21390127

1. Sawa Tomohiro (30284756)

# of Collaborated Projects: 4 results

# of Collaborated Products: 10 results
2. Ono Katsuhiko (80573592)

# of Collaborated Projects: 4 results

# of Collaborated Products: 6 results
3. NODA Masatoshi (60164703)

# of Collaborated Projects: 2 results

# of Collaborated Products: 36 results
4. SHIMIZU Takeshi (70312840)

# of Collaborated Projects: 2 results

# of Collaborated Products: 20 results
5. YAHIRO Kinnosuke (80345024)

# of Collaborated Projects: 2 results

# of Collaborated Products: 30 results
6. MORINAGA Naoko (20092108)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
7. KUWABARA Satoshi (70282481)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. MORI Masahiro (70345023)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
9. 小倉康平 (00586612)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
10. 荒木令江 (80253722)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. Nishimura Akiyuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. SUTO Akira

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. SUZUKI Kotaro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. MATSUMOTO Ayako

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. MATSUMOTO Akio

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 井田智章

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
17. 西田基宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 藤井重元

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 赤池孝章

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
20. 武田弘資

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 伊豫田淳

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 中島裕史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 中谷晴昭

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Tsutsuki Hiroyasu 津々木 博康

TSUTSUKI Hiroyasu 津々木 博康

Research Projects

Research Products

Co-Researchers

腸管出血性大腸菌毒素SubABの宿主獲得免疫破綻機構とその感染病態制御法の解明Principal Investigator

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Molecular mechanisms of inhibitory regulation of NLRP3 inflammasome by reactive sulfur species

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Elucidation of the redox activation mechanism of enterohemorrhagic Escherichia coli toxin SubAB and the infection controlPrincipal Investigator

Principal Investigator

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Review Section

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Mechanisms of intracellular bacterial killing induced by reactive sulfur species

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Review Section

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Molecular mechanisms of NLRP3 inflammasome activation via glutathione efflux

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Molecular analysis for pathogenesis of SubAB produced by Enterohemorrhagic Escherichia coli through the inhibitory effects on host innate immunityPrincipal Investigator

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Reactive sulfur metabolomics for the study of cellular sulfur dynamics

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Elucidation of the pathogenic reinforcement action of enterohemorrhagic Escherichia coli produced SubAB

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Elucidation of Shiga-toxigenic Escherichia coli produced Subtilase cytotoxin-induced cell damage mechanism.

Principal Investigator

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[Book] 生体の科学（特集 タンパク質・核酸の分子修飾）2018

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[Journal Article] Redox Biology Involved in the Toxicity of Enterohemorrhagic <i>Escherichia coli</i> Toxin SubAB2024

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[Journal Article] Regulation of innate immune and inflammatory responses by supersulfides2024

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[Journal Article] Alkyl gallates inhibit serine O-acetyltransferase in bacteria and enhance susceptibility of drug-resistant Gram-negative bacteria to antibiotics2023

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Tsutsuki Hiroyasu 津々木博康

TSUTSUKI Hiroyasu 津々木博康

[Book] 生体の科学（特集タンパク質・核酸の分子修飾）2018