WAKAMATSU Ei 若松英

… Alternative Names

Wakamatsu Ei 若松英

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Researcher Number	40632617
Other IDs
Affiliation (Current)	2025: 東京医科大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help	2019 – 2025: 東京医科大学, 医学部, 講師 2015 – 2017: 東京理科大学, 研究推進機構生命医科学研究所, 助教
Review Section/Research Field	Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related / Immunology Except Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related / Tumor biology
Keywords	Principal Investigator 腫瘍免疫 / CTLA4 / 免疫記憶 / 疲弊化 / CTLA-4 / CAR-T細胞 / イメージング / 免疫チェックポイント分子 / MHC class II / トロゴサイトーシス … More / T細胞 / LAG-3 / シグナル / 増殖 / 分化 / 末梢由来制御性T細胞 / CD28 / 制御性T細胞 … More Except Principal Investigator シグナル伝達 / 細胞療法 / イメージング / 免疫チェックポイント / 免疫シナプス / マイクロクラスター / 分子イメージング / シグナル伝達分子 / CAR-T細胞 / キメラ抗原受容体 / ICOS / 2B4 / T細胞補助刺激受容体 / CD8 T細胞 / 腫瘍免疫 / LAG-3 / T細胞補助シグナル / T細胞疲弊 / 腫瘍化 / マスト細胞 / がん / Akt / PI3K / c-Kit / オルガネラ / GIST / STAT5 / PI3K-Akt / Kitチロシンキナーゼ / マスト細胞腫 Less

CD28シグナル誘導ブースター分子を用いたがん微小環境抵抗性CAR-T細胞の開発Principal Investigator
- Principal Investigator
  
  若松英
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Tokyo Medical University
抗腫瘍免疫応答における抑制性補助刺激分子LAG-3の「負」と「正」の役割の解明
- Principal Investigator
  
  豊田博子
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Tokyo Medical University
Development of the basis of the crosstalk between T cell costimulatory receptors and chimeric antigen receptors
- Principal Investigator
  
  横須賀忠
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Tokyo Medical University
CTLA4の細胞内輸送を利用した疲弊化回避型CAR-T細胞の開発Principal Investigator
- Principal Investigator
  
  若松英
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Tokyo Medical University
Molecualr imaging for development of chimeric antigen receptors (CARs) resistant to T cell exhaustion
- Principal Investigator
  
  Yokosuka Tadashi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Tokyo Medical University
Using molecular imaging, analysis of LAG-3-mediated suppression of anti-tumor immune responsePrincipal Investigator
- Principal Investigator
  
  Wakamatsu Ei
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Tokyo Medical University
Molecular mechanisms of mast cell tumorigenesis process
- Principal Investigator
  
  Abe Ryo
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor biology
- Research Institution
  Tokyo University of Science
Role of CD28 co-stimulation in homeostasis of peripherally-derived regulatory T cellsPrincipal Investigator
- Principal Investigator
  
  Wakamatsu Ei
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Immunology
- Research Institution
  Tokyo University of Science

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015

All Journal Article Presentation Book

[Book] Basic Immunology and Its Clinical Application2024
- Author(s)
  Nishi Wataru, Ei Wakamatsu, Hiroaki Machiyama, Ryohei Matsushima, Yosuke Yoshida, Tetsushi Nishikawa, Hiroko Toyota, Masae Furuhata, Hitoshi Nishijima, Arata Takeuchi, Makoto Suzuki, Tadashi Yokosuka
- Total Pages
  258
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-23K27466
[Book] 腫瘍内科2022
- Author(s)
  横須賀忠、若松英、西嶋仁、西航、松島遼平、西川哲史、町山裕亮、竹内新
- Total Pages
  139
- Publisher
  科学評論社
- Data Source
  KAKENHI-PROJECT-20H03536
[Book] Precision Medicine2022
- Author(s)
  横須賀忠、若松英、西嶋仁、竹内新、町山裕亮
- Total Pages
  90
- Publisher
  北隆館
- Data Source
  KAKENHI-PROJECT-20H03536
[Book] 実験医学増刊号「新規の創薬モダリティ　細胞医薬」2020
- Author(s)
  横須賀忠, 若松英, 西嶋仁, 竹原朋宏, 西航, 塚本昌子, 町山裕亮
- Total Pages
  241
- Publisher
  羊土社
- ISBN
  9784260042383
- Data Source
  KAKENHI-PROJECT-20H03536
[Book] 臨床免疫・アレルギー科, マスト細胞をがん化に導くKitのシグナル伝達は細胞膜ではなく「エンドリソソーム」, 「小胞体」で起こる2015
- Author(s)
  小幡裕希、豊島翔太、若松英、小川修平、江角浩安、安部良
- Publisher
  科学評論社
- Data Source
  KAKENHI-PROJECT-15K06843
[Journal Article] Evaluation of therapeutic PD-1 antibodies by an advanced single-molecule imaging system detecting human PD-1 microclusters2023
- Author(s)
  Nishi Wataru、Wakamatsu Ei、Machiyama Hiroaki、Matsushima Ryohei、Saito Kensho、Yoshida Yosuke、Nishikawa Tetsushi、Takehara Tomohiro、Toyota Hiroko、Furuhata Masae、Nishijima Hitoshi、Takeuchi Arata、Azuma Miyuki、Suzuki Makoto、Yokosuka Tadashi
- Journal Title
  
  Nature Communications
  
  Volume: 14 Issue: 1 Pages: 1-16
- DOI
  10.1038/s41467-023-38512-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07124, KAKENHI-PROJECT-22K07261, KAKENHI-PROJECT-22K08487, KAKENHI-PUBLICLY-23H04790, KAKENHI-PROJECT-23K27466
[Journal Article] PD-L2 suppresses T cell signaling via coinhibitory microcluster formation and SHP2 phosphatase recruitment2021
- Author(s)
  Tomohiro Takehara, Ei Wakamatsu, Hiroaki Machiyama, Wataru Nishi, Katsura Emoto, Miyuki Azuma, Kenzo Soejima, Koichi Fukunaga, Tadashi Yokosuka
- Journal Title
  
  Communications Biology
  
  Volume: 4 Issue: 1 Pages: 1-12
- DOI
  10.1038/s42003-021-02111-3
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22545, KAKENHI-PROJECT-20J10564, KAKENHI-PROJECT-18K06165, KAKENHI-ORGANIZER-16H06495, KAKENHI-WRAPUP-21H00461, KAKENHI-PROJECT-19H03671, KAKENHI-PROJECT-19K07718, KAKENHI-INTERNATIONAL-16K21731, KAKENHI-PROJECT-20H03536
[Journal Article] Strong TCR stimulation promotes the stabilization of Foxp3 expression in regulatory T cells induced in vitro through increasing the demethylation of Foxp3 CNS2.2018
- Author(s)
  Wakamatsu, E., Omori, H., Kawano, A. & Abe, R.
- Journal Title
  
  Mol. Immunol.
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K06843
[Journal Article] CD28 co-stimulation is dispensable for the steady state homeostasis of intestinal regulatory T cells.2018
- Author(s)
  Wakamatsu E, Omori H, Tabata Y, Akieda Y, Watanabe S, Ogawa S, Abe R.
- Journal Title
  
  International Immunology
  
  Volume: 30 Issue: 4 Pages: 171-180
- DOI
  10.1093/intimm/dxy013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K06843
[Journal Article] The spleen is the site where mast cells are induced in the development of food allergy2017
- Author(s)
  Toyoshima, S., Wakamatsu, E., Ishida, Y., Obata, Y., Kurashima, Y., Kiyono, T. & Abe, R.
- Journal Title
  
  International Immunology
  
  Volume: 29 Issue: 1 Pages: 31-45
- DOI
  10.1093/intimm/dxx005
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K06843, KAKENHI-PROJECT-16K18427
[Journal Article] Cell cycle arrest caused by MEK/ERK signaling is a mechanism for suppressing growth of antigen-hyperstimulated effector T cells2016
- Author(s)
  Ohtsuka, S., Ogawa, S., Wakamatsu, E., Abe, R.
- Journal Title
  
  International Immunology
  
  Volume: 11 Pages: 547-557
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K06843
[Journal Article] Defects in regulatory T cells due to CD28 deficiency induce a qualitative change of allogeneic immune response in chronic graft-versus-host disease2015
- Author(s)
  Akieda Y, Wakamatsu E, Nakamura T, Ishida Y, Ogawa S, Abe R
- Journal Title
  
  J. Immunol.
  
  Volume: 194 Issue: 9 Pages: 4162-4174
- DOI
  10.4049/jimmunol.1402591
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06843
[Presentation] Fine tuning of T cell activation by multistep regulation of CD6 and its ligand CD166.2024
- Author(s)
  Arata Takeuchi, Tatsushi Nishikawa, Hiroaki Machiyama, Ei Wakamatsu, Hitoshi Nishijima, Masae Furuhata, Hiroko Toyota, Ryohei Matsushima, Yosuke Yoshida, Tadashi Yokosuka
- Organizer
  第52回日本免疫学会
- Data Source
  KAKENHI-PROJECT-22K07261
[Presentation] CD4/CD8 coreceptor binding to MHCs positively regulate CAR-T cell response via translocation of Lck into CAR microclusters.2024
- Author(s)
  Hiroaki Machiyama, Ei Wakamatsu, Arata Takeuchi, Hitoshi Nishijima, Maksim Mamonkin, Malcolm K Brenner, Tadashi Yokosuka
- Organizer
  第52回日本免疫学会
- Data Source
  KAKENHI-PROJECT-22K07261
[Presentation] A novel mechanism for LAG-3-mediated cell-extrinsic suppression of CD4+ T cell activation through trogocytosis of MHC class II2024
- Author(s)
  Ei Wakamatsu, Hiroaki Machiyama, Hiroko Toyota, Masae Furuhata, Hitoshi Nishijima, Arata Takeuchi, Tadashi Yokosuka
- Organizer
  第52回日本免疫学会
- Data Source
  KAKENHI-PROJECT-22K07261
[Presentation] Comparison of linear and parallel co-stimulatory signaling via CD28 in the activation of CAR-T Cells2024
- Author(s)
  Tetsushi Nishikawa1,, Arata Takeuchi, Hiroaki Machiyama, Ei Wakamatsu, Hitoshi Nishijima, Masae Furuhata, Hiroko Toyota, Wataru Nishi, Ryohei Matsushima, Yosuke Yoshida, Tadashi Yokosuka
- Organizer
  第52回日本免疫学会
- Data Source
  KAKENHI-PROJECT-22K07261
[Presentation] CD4/CD8 coreceptor binding to MHCs positively regulate CAR-T cell response via translocation of Lck into CAR microclusters2024
- Author(s)
  Hiroaki Machiyama、Ei Wakamatsu、Arata Takeuchi、Hitoshi Nishijima、Tetsushi Nishikawa、Ryohei Matsushima、Yosuke Yoshida、Masae Furuhata、Hiroko Toyota、Mamonkin Maksim、Brenner Malcolm K、Tadashi Yokosuka
- Organizer
  第52回日本免疫学会総会
- Data Source
  KAKENHI-PROJECT-23K27466
[Presentation] 超解像イメージングが解明する免疫チェックポイント阻害療法の分子メカニズム2024
- Author(s)
  横須賀忠、西航、松島遼平、西川哲史、吉田洋輔、竹原朋宏、西嶋仁、町山裕亮、若松英、竹内新
- Organizer
  第51回日本集中治療医学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-23K27466
[Presentation] PD-1-mediated suppression of CAR-T cells via CAR signalosomes colocalized by PD-12024
- Author(s)
  Yosuke Yoshida1,2, Hiroaki Machiyama2, Ei Wakamatsu, Arata Takeuchi, Hitoshi Nishijima, Hiroko Toyota, Masae Furuhata, Ryohei Matsushima, Tetsushi Nishikawa, Tadashi Yokosuka
- Organizer
  第52回日本免疫学会
- Data Source
  KAKENHI-PROJECT-22K07261
[Presentation] Comparison of linear and parallel co-stimulatory signaling via CD28 in the activation of Chimeric Antigen Receptor T Cells2024
- Author(s)
  Tetsushi Nishikawa、Arata Takeuchi、Hiroaki Machiyama、Ei Wakamatsu、Hitoshi Nishijima、Masae Furuhata、Hiroko Toyota、Nishi Wataru、Ryohei Matsushima、Yosuke Yoshida、Tadashi Yokosuka
- Organizer
  第52回日本免疫学会総会
- Data Source
  KAKENHI-PROJECT-23K27466
[Presentation] PD-1-mediated suppression of CAR-T cells via CAR signalosomes colocalized by PD-12024
- Author(s)
  Yosuke Yoshida、Hiroaki Machiyama、Ei Wakamatsu、Arata Takeuchi、Hitoshi Nishijima、Tetsushi Nishikawa、Ryohei Matsushima、Masae Furuhata、Hiroko Toyota、Mamonkin Maksim、Brenner Malcolm K、Tadashi Yokosuka
- Organizer
  第52回日本免疫学会総会
- Data Source
  KAKENHI-PROJECT-23K27466
[Presentation] Fine tuning of T cell activation by multistep regulation of CD6 and its ligand CD1662024
- Author(s)
  Arata Takeuchi、Tetsushi Nishikawa、Hiroaki Machiyama、Ei Wakamatsu、Hitoshi Nishijima、Masae Furuhata、Hiroko Toyota、Ryohei Matsushima、Yosuke Yoshida、Tadashi Yokosuka
- Organizer
  第52回日本免疫学会総会
- Data Source
  KAKENHI-PROJECT-23K27466
[Presentation] c-SMAC formation in double positive T cells functions as a checkpoint in thymic selection2024
- Author(s)
  Hitoshi Nishijima、Ei Wakamatsu、Hiroaki Machiyama、Arata Takeuchi、Tetsushi Nishikawa、Yosuke Yoshida、Tadashi Yokosuka
- Organizer
  第52回日本免疫学会総会
- Data Source
  KAKENHI-PROJECT-23K27466
[Presentation] Super-resolution imaging elucidates the molecular mechanism of CAR-T cells and ICI immunotherapy2023
- Author(s)
  横須賀忠、若松英、西嶋仁、竹内新、松島遼平、西航、西川哲史、吉田洋輔、Maksim Mamokin、Malcolm K Brenner、町山裕亮
- Organizer
  第85回日本血液学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-23K27466
[Presentation] 分子イメージングシステムを用いた補助刺激受容体2B4のT細胞におけるスイッチング機構の解明とCAR-T細胞への応用2023
- Author(s)
  松島遼平、若松英、齋藤顕昇、吉田洋輔、西川哲史、西航、豊田博子、古畑昌枝、町山裕亮、西嶋仁、竹内新、鈴木実、横須賀忠
- Organizer
  第26回日本がん免疫学会総会
- Data Source
  KAKENHI-PROJECT-23K27466
[Presentation] ヒトPD-1マイクロクラスターの1分子イメージングを用いた治療用抗PD-1/PD-L1抗体の機能評価の研究2023
- Author(s)
  横須賀忠、西航、若松英、町山裕亮、松島遼平、吉田洋輔、西川哲史、竹原朋宏、西嶋仁、竹内新、東みゆき、鈴木実
- Organizer
  第26回日本がん免疫学会総会
- Data Source
  KAKENHI-PROJECT-23K27466
[Presentation] キメラ抗原受容体CAR-T細胞の初期の活性化と細胞応答におけるLckの分子動態と共受容体の関与2023
- Author(s)
  町山裕亮、若松英、西嶋仁、竹内新、横須賀忠
- Organizer
  第32回京都T細胞カンファレンス
- Data Source
  KAKENHI-PROJECT-23K27466
[Presentation] 免疫チェックポイント阻害剤の効果に影響するヒトPD-1変異の解析2023
- Author(s)
  西航、若松英、町山裕亮、松島遼平、西川哲史、吉田洋輔、豊田博子、古畑昌枝、西嶋仁、竹内新、池田公英、鈴木実、横須賀忠
- Organizer
  第64回日本肺癌学会学術集会
- Data Source
  KAKENHI-PROJECT-23K27466
[Presentation] 超解像イメージングが解明するCAR-T細胞療法とICI療法のシグナル伝達2022
- Author(s)
  横須賀忠、若松英、竹内新、町山裕亮
- Organizer
  第45回日本造血・免疫細胞療法学会
- Invited
- Data Source
  KAKENHI-PROJECT-20H03536
[Presentation] Dynamics of the PI3K signaling pathway through the cytosolic domain of ICOS2022
- Author(s)
  Ei Wakamatsu, Hiroaki Machiyama, Hiroko Toyota, Masae Furuhata, Hitoshi Nishijima, Arata Takeuchi, Tadashi Yokosuka
- Organizer
  第51回日本免疫学会総会
- Data Source
  KAKENHI-PROJECT-20H03536
[Presentation] Binding of the CD4/CD8 coreceptor to an MHC molecule positively modulates CAR-T cell response2022
- Author(s)
  Hiroaki Machiyama, Ei Wakamatsu, Arata Takeuchi, Hitoshi Nishijima, Masae Furuhata, Hiroko Toyota, Maksim Mamonkin, Malcolm K Brenner, Tadashi Yokosuka
- Organizer
  第51回日本免疫学会総会
- Data Source
  KAKENHI-PROJECT-20H03536
[Presentation] Extrinsic and intrinsic inhibition of T cell response by co-inhibitory receptors, TIGIT and CD962022
- Author(s)
  Ann Hattori, Ei Wakamatsu, Hiroaki Machiyama, Ryuji Hashimoto, Hiroko Toyota, Masae Furuhata, Hitoshi Nishijima, Arata Takeuchi, Tadashi Yokosuka
- Organizer
  第51回日本免疫学会総会
- Data Source
  KAKENHI-PROJECT-20H03536
[Presentation] Evaluation of therapeutic PD-1 antibodies by a newly established imaging system for human PD-1 microclusters2022
- Author(s)
  Wataru Nishi，Ei Wakamatsu、Ryohei Matsushima、Tetsushi Nishikawa, Tomohiro Takehara, Hiroaki Machiyama, Hitoshi Nishijima, Arata Takeuchi, Miyuki Azuma, Makoto Suzuki, and Tadashi Yokosuka
- Organizer
  第26回日本がん免疫学会総会
- Data Source
  KAKENHI-PROJECT-20H03536
[Presentation] Binding of the CD4/CD8 coreceptor to an MHC molecule positively modulates CAR-T cell response2022
- Author(s)
  Machiyama　H, Wakamatsu　E, Takeuchi　A, Nishijima　H, Furuhata 　M, Toyota　H, Mamonkin　M, Brenner 　 K M , YokosukaT.
- Organizer
  第51回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-19K07718
[Presentation] キメラ抗原受容体CAR-T細胞の初期の活性化と細胞応答性におけるLckの分子動態とCD8-MHC相互作用の寄与2022
- Author(s)
  町山裕亮、若松英、西嶋仁、竹内新、横須賀忠、Maksim Mamonkin, Malcolm K Brenner
- Organizer
  第31回 Kyoto T Cell Conference
- Data Source
  KAKENHI-PROJECT-20H03536
[Presentation] Extrinsic and intrinsic inhibition of T cell response by co-inhibitory receptors, TIGIT and CD962022
- Author(s)
  Hattori　Ann, Wakamatsu　E, Machiyama　H, Hashimoto　R, Toyota　 H, Furuhata　M, Nishijima　H, Takeuchi　A, Yokosuka　T.
- Organizer
  第51回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-19K07718
[Presentation] Dynamics of the PI3K signaling pathway through the cytosolic domain of ICOS2022
- Author(s)
  Wakamatsu　E, Machiyama　H, Toyota 　H, Furuhata　M, Nishijima　H, Takeuchi　A, Yokosuka　T.
- Organizer
  第51回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-19K07718
[Presentation] CAR-T細胞活性化における共受容体CD8の役割2022
- Author(s)
  町山裕亮, 若松英, Mamonkin Maksim, Brenner K. Malcom, 横須賀忠
- Organizer
  第26回日本がん免疫学会総会
- Data Source
  KAKENHI-PROJECT-20H03536
[Presentation] LAG-3-mediated trogocytosis of MHC class II indirectly regulates CD4+ T cell activation2021
- Author(s)
  Ei Wakamatsu, Hiroaki Machiyama, Hiroko Toyota, Masae Furuhata, Hitoshi Nishijima, Arata Takeuchi, Tadashi Yokosuka
- Organizer
  第50回日本免疫学会総会
- Data Source
  KAKENHI-PROJECT-20H03536
[Presentation] Establishment of a molecular imaging system to evaluate the T cell exhaustion releasing function of human PD-1/PD-L1 antibodies.2021
- Author(s)
  Nishi Wataru, Ei Wakamatsu, Nishiakwa Tetsuji, Takehara Tomohiro, Toyoda Hiroko, Furuhata Masae, Hiroaki Machiyama, Nishijima Hitoshi, Azuma Miyuki, Suzuki Makoto, Tadashi Yokosuka
- Organizer
  第50回日本免疫学会総会
- Data Source
  KAKENHI-PROJECT-20H03536
[Presentation] Human T cells illustrate TCR microclusters by triggering with bispecific antibodies, blinatumomab2021
- Author(s)
  Hitoshi Nishijima, Arata Takeuchi, Ei Wakamatsu, Wataru Nishi, Hiroaki Machiyama, Tadashi Yokosuka
- Organizer
  第50回日本免疫学会総会
- Data Source
  KAKENHI-PROJECT-20H03536
[Presentation] LAG-3発現CD4+ T細胞はMHC class IIのトロゴサイトーシスを介して間接的にCD4+ T細胞の活性化を抑制する2021
- Author(s)
  若松英、町山裕亮、豊田博子、古畑昌枝、西嶋仁、竹内新、横須賀忠
- Organizer
  第30回 Kyoto T Cell Conference
- Data Source
  KAKENHI-PROJECT-20H03536
[Presentation] CAR-T細胞の抗原認識と活性化を担うCARマイクロクラスターの分子イメージング解析2021
- Author(s)
  横須賀忠、若松英、西嶋仁、竹内新、竹原朋宏、西航、西川哲史、Maksim Mamokin、Malcolm K. Brenner、町山裕亮
- Organizer
  第25回日本がん免疫学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-20H03536
[Presentation] 分子イメージングによるT細胞活性化機構の解明とがん免疫2021
- Author(s)
  横須賀忠、若松英、西嶋仁、竹内新、竹原朋宏、西航、西川哲史、Maksim Mamokin、Malcolm K. Brenner、町山裕亮
- Organizer
  第61回日本リンパ網内系学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-20H03536
[Presentation] LAG-3発現CD8+ T細胞は抗原提示細胞からMHC class IIをトロゴサイトーシスすることでCD4+ T細胞の活性化を間接的に抑制する2021
- Author(s)
  若松英、町山裕亮、豊田博子、古畑昌枝、西嶋仁、竹内新、横須賀忠
- Organizer
  がん免疫学会
- Data Source
  KAKENHI-PROJECT-19K07718
[Presentation] LAG-3-mediated trogocytosis of MHC class II indirectly regulates CD4+ T cell activation2021
- Author(s)
  Ei Wakamatsu, Hiroaki Machiyama, Hiroko Toyota, Masae Furuhata, Hitoshi Nishijima, Arata Takeuchi, Tadashi Yokosuka
- Organizer
  日本免疫学会
- Data Source
  KAKENHI-PROJECT-19K07718
[Presentation] LAG-3発現CD4+ T細胞はMHC class IIのトロゴサイトーシスを介して間接的にCD4+ T細胞の活性化を抑制する2021
- Author(s)
  若松英、町山裕亮、豊田博子、古畑昌枝、西嶋仁、竹内新、横須賀忠
- Organizer
  Kyoto T cell conference
- Data Source
  KAKENHI-PROJECT-19K07718
[Presentation] LAG-3発現T細胞は抗原提示細胞からMHC class IIをトロゴサイトーシスすることでCD4+ T細胞の活性化を間接的に抑制する2021
- Author(s)
  若松英、町山裕亮、豊田博子、古畑昌枝、西嶋仁、竹内新、横須賀忠
- Organizer
  サイトカインインターフェロン学会
- Data Source
  KAKENHI-PROJECT-19K07718
[Presentation] The kinase Lck activate CAR-T cells independently upon co-receptor association.2021
- Author(s)
  Hiroaki Machiyama, Ei Wakamatsu, Masae Furuhata, Hiroko Toyota, Mamonkin Maksim, Brenner Malcolm K, Tadashi Yokosuka
- Organizer
  第50回日本免疫学会総会
- Data Source
  KAKENHI-PROJECT-20H03536
[Presentation] Visualizing of neo-self phenomena in chimeric antigen receptor (CAR)-T cells.2020
- Author(s)
  町山裕亮, 若松英, 秦喜久美, 矢那瀬紀子, 竹原朋宏, 西航, Mamonkin M, Brenner MK, 横須賀忠
- Organizer
  第58回日本生物物理学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-20H03536
[Presentation] 分子イメージングによるPD-1ーPD-L2を介するT細胞抑制機構の解明2020
- Author(s)
  竹原朋宏, 若松英, 町山裕亮, 副島研造, 福永興壱, 横須賀忠
- Organizer
  第24回日本がん免疫学会総会
- Data Source
  KAKENHI-PROJECT-20H03536
[Presentation] Role of cytoskeleton in Chimeric antigen receptor (CAR)-T cell therapy.2020
- Author(s)
  Machiyama H, Wakamatsu E, Yokosuka T
- Organizer
  The 43rd Annual Meeting of Molecular Biology Society of Japan
- Invited
- Data Source
  KAKENHI-PROJECT-20H03536
[Presentation] 一分子動態解析法を用いたT細胞活性化におけるシグナルソームの時空間的制御機構の解明～簡単・簡便なキメラ抗原受容体CAR-T細胞療法に向けて～2020
- Author(s)
  町山裕亮, 若松英, 矢那瀬紀子, 横須賀忠
- Organizer
  第36回日本DDS学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-20H03536
[Presentation] Indirect suppression of CD4+ T cell activation by LAG3-mediated trogocytosis of MHC Class II.2019
- Author(s)
  Wakamatsu Ei, Machiyama Hiroaki, Toyota Hiroko, Furuhata Masae, Hata Kikumi, Yanase Noriko, Yokosuka Tadashi
- Organizer
  第48回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-19K07718
[Presentation] IL-2 production is negatively regulated by free fatty acid receptor 2 (Ffar2) mediated signaling.2017
- Author(s)
  田畑由紀, 小川修平, 若松　英, 渡辺志帆, 安部良
- Organizer
  The 46th Annual Meeting of the Japanese society of Immunology
- Data Source
  KAKENHI-PROJECT-15K06843
[Presentation] The responsiveness to TCR stimulation of Treg subsets influences the dependency of their proliferation on CD282017
- Author(s)
  若松英
- Organizer
  第7回　International Kyoto T cell Conference
- Place of Presentation
  芝蘭会館（京都府・京都市）
- Year and Date
  2017-03-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19137
[Presentation] The responsiveness to TCR stimulation of Treg subsets influences the dependency of their proliferation on CD282017
- Author(s)
  Wakamatsu, E., Omori, H., Ogawa, S. & Abe R.
- Organizer
  7th International Workshop of Kyoto T Cell Conference
- Place of Presentation
  京都大学, 京都
- Year and Date
  2017-03-13
- Data Source
  KAKENHI-PROJECT-15K06843
[Presentation] The effect of TCR and CD28 stimulation on tyrosine phosphorylation of CD282016
- Author(s)
  Ogawa, S., Watanabe, S., Wakamatsu, E., Ohtsuka, S. & Abe, R.
- Organizer
  The 45th Annual Meeting of The Japanese Society for Immunology
- Place of Presentation
  沖縄コンベンションセンター, 沖縄
- Year and Date
  2016-12-05
- Data Source
  KAKENHI-PROJECT-15K06843
[Presentation] 細胞増殖へのCD28シグナルの効果は制御性T細胞T細胞サブセット間で異なる2016
- Author(s)
  若松英
- Organizer
  第26回　Kyoto T cell Conference
- Place of Presentation
  芝蘭会館（京都府・京都市）
- Year and Date
  2016-05-20
- Data Source
  KAKENHI-PROJECT-15K19137
[Presentation] 細胞増殖へのCD28シグナルの効果は制御性T細胞サブセット間で異なる2016
- Author(s)
  若松英, 大森宏樹, 田畑由紀, 小川修平, 安部良
- Organizer
  第26回 Kyoto T Cell Conference
- Place of Presentation
  比叡山延暦寺会館, 大津
- Year and Date
  2016-05-20
- Data Source
  KAKENHI-PROJECT-15K06843
[Presentation] Differential roles of CD28 YMNM and PYAP motifs in acute GVHD induction2015
- Author(s)
  Ogawa, S., Watanabe, S., Wakamatsu, E., Ohtsuka, S. & Abe, R.
- Organizer
  The 44th Annual Meeting of The Japanese Society for Immunology
- Place of Presentation
  札幌, 札幌コンベンションセンター
- Year and Date
  2015-11-18
- Data Source
  KAKENHI-PROJECT-15K06843
[Presentation] CD28 cosimulation is required for the maintenance but not the development of peripherally derived regulatory T cells2015
- Author(s)
  Wakamatsu, E., Akieda, Y., Ohmori, H. & Abe, R.
- Organizer
  Keystone symposia, T Cells: Regultion and Effector Function (D3)
- Place of Presentation
  Snowbird, utah
- Year and Date
  2015-04-01
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06843
[Presentation] CD28 co-stimulation is dispensable for the development of peripherally-derived regulatory T cells2015
- Author(s)
  Ohmori, H., Wakamatsu, E., Kawano, A., Tabata, Y., Ogawa, S. & Abe, R.
- Organizer
  The 44th Annual Meeting of The Japanese Society for Immunology
- Place of Presentation
  札幌, 札幌コンベンションセンター
- Year and Date
  2015-11-18
- Data Source
  KAKENHI-PROJECT-15K06843
[Presentation] CD28 makes different impacts on thymus-and peripherally-derived regulatory T cell for their maintenance2015
- Author(s)
  Wakamatsu, E., Ohmori, H., Ogawa, S. & Abe, R.
- Organizer
  The 44th Annual Meeting of The Japanese Society for Immunology
- Place of Presentation
  札幌, 札幌コンベンションセンター
- Year and Date
  2015-11-18
- Data Source
  KAKENHI-PROJECT-15K06843
[Presentation] Role of CD28 co-stimulation in the homeostasis of peripherally derived regulatory T cells2015
- Author(s)
  Wakamatsu,E., Omori,H., Akieda,Y., Ogawa,S. & Abe, R.
- Organizer
  Kyoto T cell Conference 第25回学術集会
- Place of Presentation
  京都, 京都大学
- Year and Date
  2015-05-15
- Data Source
  KAKENHI-PROJECT-15K06843
[Presentation] Role of CD28 co-stimulation in the homeostasis of peripherally derived regulatory T cells.2015
- Author(s)
  Wakamatsu E, Ohmori H, Akieda Y, Ogawa S, Abe R
- Organizer
  25th Kyoto T Cell Conference
- Place of Presentation
  京都、京都大学芝蘭会館
- Year and Date
  2015-05-15
- Data Source
  KAKENHI-PROJECT-15K19137
[Presentation] CD28 co-stimulation is dispensable for the development of peripherally-derived regulatory T cells.2015
- Author(s)
  Ohmori H, Wakamatsu E, Kawano A, Tabata Y, Ogawa S, Abe R
- Organizer
  The 44th Annual Meeting of The Japanese Society for Immunology
- Place of Presentation
  札幌、札幌コンベンションセンター
- Year and Date
  2015-11-18
- Data Source
  KAKENHI-PROJECT-15K19137
[Presentation] CD28 makes different impacts on thymus-and peripherally-derived regulatory T cell for their maintenance.2015
- Author(s)
  Wakamatsu E, Ohmori H, Ogawa S, Abe R
- Organizer
  The 44th Annual Meeting of The Japanese Society for Immunology
- Place of Presentation
  札幌、札幌コンベンションセンター
- Year and Date
  2015-11-18
- Data Source
  KAKENHI-PROJECT-15K19137
[Presentation] Oncogenic Kit signals on intracellular compartments are required for neoplastic mast cell proliferation2015
- Author(s)
  小幡裕希, 豊島翔太, 堀川啓太, 若松英, 小川修平, 西田俊朗, 江角浩安, 安部良
- Organizer
  第3回ブリストル血液アカデミー
- Place of Presentation
  札幌, 京王プラザホテル札幌
- Year and Date
  2015-09-05
- Invited
- Data Source
  KAKENHI-PROJECT-15K06843
[Presentation] Activated T cells control the pathogenic mast cells under allergic conditions2015
- Author(s)
  Toyoshima, S., Wakamatsu, E., Obata, Y., Ogawa, S. & Abe, R.
- Organizer
  The 44th Annual Meeting of The Japanese Society for Immunology
- Place of Presentation
  札幌, 札幌コンベンションセンター
- Year and Date
  2015-11-18
- Data Source
  KAKENHI-PROJECT-15K06843

1. Yokosuka Tadashi (10359599)

# of Collaborated Projects: 2 results

# of Collaborated Products: 34 results
2. 町山裕亮 (40704606)

# of Collaborated Projects: 2 results

# of Collaborated Products: 33 results
3. Abe Ryo (20159453)

# of Collaborated Projects: 1 results

# of Collaborated Products: 17 results
4. 小幡裕希 (20609408)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
5. 豊田博子 (80468660)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 竹内新 (00360579)

# of Collaborated Projects: 1 results

# of Collaborated Products: 13 results
7. 西嶋仁 (60425410)

# of Collaborated Projects: 1 results

# of Collaborated Products: 12 results

WAKAMATSU Ei 若松 英

Wakamatsu Ei 若松 英

Research Projects

Research Products

Co-Researchers

CD28シグナル誘導ブースター分子を用いたがん微小環境抵抗性CAR-T細胞の開発Principal Investigator

Principal Investigator

Project Period (FY)

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Research Institution

抗腫瘍免疫応答における抑制性補助刺激分子LAG-3の「負」と「正」の役割の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of the basis of the crosstalk between T cell costimulatory receptors and chimeric antigen receptors

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

CTLA4の細胞内輸送を利用した疲弊化回避型CAR-T細胞の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecualr imaging for development of chimeric antigen receptors (CARs) resistant to T cell exhaustion

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Using molecular imaging, analysis of LAG-3-mediated suppression of anti-tumor immune responsePrincipal Investigator

Principal Investigator

Project Period (FY)

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Review Section

Research Institution

Molecular mechanisms of mast cell tumorigenesis process

Principal Investigator

Project Period (FY)

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Research Field

Research Institution

Role of CD28 co-stimulation in homeostasis of peripherally-derived regulatory T cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Basic Immunology and Its Clinical Application2024

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[Book] 腫瘍内科2022

Author(s)

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[Book] Precision Medicine2022

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[Book] 実験医学増刊号「新規の創薬モダリティ 細胞医薬」2020

Author(s)

Total Pages

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Data Source

[Book] 臨床免疫・アレルギー科, マスト細胞をがん化に導くKitのシグナル伝達は細胞膜ではなく「エンドリソソーム」, 「小胞体」で起こる2015

Author(s)

Publisher

Data Source

[Journal Article] Evaluation of therapeutic PD-1 antibodies by an advanced single-molecule imaging system detecting human PD-1 microclusters2023

Author(s)

WAKAMATSU Ei 若松英

Wakamatsu Ei 若松英

[Book] 実験医学増刊号「新規の創薬モダリティ　細胞医薬」2020