Toyota Hiroko 豊田博子

… Alternative Names

豊田博子トヨタヒロコ

TOYOTA Hiroko 豊田博子

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Researcher Number	80468660
Other IDs
Affiliation (Current)	2026: 東京医科大学, 医学部, 助手
Affiliation (based on the past Project Information) *help	2024: 東京医科大学, 医学部, 助手 2014 – 2020: 東京医科大学, 医学部, 助手 2011: 東京医科大学, 医学部, 助手 2009: 東京医科大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related / Experimental pathology Except Principal Investigator Biomedical engineering/Biomaterial science and engineering / Pathobiological dentistry/Dental radiology / Surgical dentistry
Keywords	Principal Investigator 腫瘍免疫 / CD8 T細胞 / LAG-3 / 病理学 / ストレス応答性MAPキナーゼ / ストストレス応答性MAPキナーゼ / ストレス応答MAPキナーゼ / ストレス応答MAPキナーゼJNK Except Principal Investigator 口腔扁平上皮癌 / がんワクチン … More / ナノ粒子 / ガンワクチン / 癌幹細胞 / 転移 / 癌 / ナノバイオ / 免疫学 / ワクチン / 免疫 / がん / CTL / ナノテクノロジー / 樹状細胞 / 炎症 / 扁平上皮癌 / 治療戦略 / 細胞死 / 薬剤耐性 Less

抗腫瘍免疫応答における抑制性補助刺激分子LAG-3の「負」と「正」の役割の解明Principal Investigator
- Principal Investigator
  
  豊田博子
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Tokyo Medical University
Study of nano particle cancer vaccines targeting for Dendritic cells.
- Principal Investigator
  
  Yanase Noriko
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biomedical engineering/Biomaterial science and engineering
- Research Institution
  Tokyo Medical University
Mechanism of allergic inflammation induction of MAP kinase JNKPrincipal Investigator
- Principal Investigator
  
  Toyota Hiroko
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Tokyo Medical University
Control of antigen-specific immune response by nanoparticles and elucidation of its cellular mechanism
- Principal Investigator
  
  Yanase Noriko
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biomedical engineering/Biomaterial science and engineering
- Research Institution
  Tokyo Medical University
Role of inflammation in the initiation and development of oral squamous cell carcinoma
- Principal Investigator
  
  MIZUGUCHI Junichiro
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathobiological dentistry/Dental radiology
- Research Institution
  Tokyo Medical University
口腔扁平上皮癌の化学療法剤耐性及び転移能獲得における細胞死関連分子の役割
- Principal Investigator
  
  納冨武則
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathobiological dentistry/Dental radiology
- Research Institution
  Tokyo Medical University
Characterization of cancer stem cells for oral squamous cell carcinoma cells and its application for treatment of oral carcinoma
- Principal Investigator
  
  MIZUGUCHI Junichiro
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  Tokyo Medical University

All 2025 2024 2019 2018 2016 2015 2014 2012 2009 Other

All Journal Article Presentation

[Journal Article] Imaging of biphasic signalosomes constructed by checkpoint receptor 2B4 in conventional and chimeric antigen receptor-T cells2025
- Author(s)
  Matsushima Ryohei、Wakamatsu Ei、Machiyama Hiroaki、Nishi Wataru、Yoshida Yosuke、Nishikawa Tetsushi、Toyota Hiroko、Furuhata Masae、Nishijima Hitoshi、Takeuchi Arata、Suzuki Makoto、Yokosuka Tadashi
- Journal Title
  
  iScience
  
  Volume: 28 Issue: 1 Pages: 111669-111669
- DOI
  10.1016/j.isci.2024.111669
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-23H04790, KAKENHI-PROJECT-23K27466, KAKENHI-PROJECT-22K07124, KAKENHI-PROJECT-22K07261, KAKENHI-PROJECT-24K10439
[Journal Article] Molecular Imaging of PD-1 Unveils Unknown Characteristics of PD-1 Itself by Visualizing “PD-1 Microclusters”2024
- Author(s)
  Nishi Wataru、Wakamatsu Ei、Machiyama Hiroaki、Matsushima Ryohei、Yoshida Yosuke、Nishikawa Tetsushi、Toyota Hiroko、Furuhata Masae、Nishijima Hitoshi、Takeuchi Arata、Suzuki Makoto、Yokosuka Tadashi
- Journal Title
  
  Advances in Experimental Medicine and Biology
  
  Volume: - Pages: 197-205
- DOI
  10.1007/978-981-99-9781-7_13
- ISBN
  9789819997800, 9789819997817
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K07124, KAKENHI-PROJECT-22K07261, KAKENHI-PROJECT-24K10439
[Journal Article] Indirect suppression of CD4 T?cell activation through LAG-3-mediated trans-endocytosis of MHC class II2024
- Author(s)
  Wakamatsu Ei、Machiyama Hiroaki、Toyota Hiroko、Takeuchi Arata、Hashimoto Ryuji、Kozono Haruo、Yokosuka Tadashi
- Journal Title
  
  Cell Reports
  
  Volume: 43 Issue: 9 Pages: 114655-114655
- DOI
  10.1016/j.celrep.2024.114655
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-23H04790, KAKENHI-PROJECT-23K27466, KAKENHI-PROJECT-22K07124, KAKENHI-PROJECT-22K07261, KAKENHI-PROJECT-23K06600, KAKENHI-PROJECT-24K10439
[Journal Article] The Multifaceted Role of PD-1 in Health and Disease2016
- Author(s)
  Badr MEISG, Hata K, Furuhata M, Toyoda H, Yokosuka T.
- Journal Title
  
  Choronic Inflammation
  
  Volume: 1 Pages: 441-457
- DOI
  10.1007/978-4-431-56068-5_34
- ISBN
  9784431560661, 9784431560685
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-ORGANIZER-16H06495, KAKENHI-PLANNED-16H06501, KAKENHI-PROJECT-16K08746, KAKENHI-INTERNATIONAL-16K21731
[Journal Article] Thy28 protects against anti-CD3-mediated thymic cell death in vivo.2015
- Author(s)
  Toyota H, Sudo K, Kojima K, Yanase N, Nagao T, Takahashi RH, Iobe H, Kuwabara T, Kakiuchi T, and Mizuguchi J.
- Journal Title
  
  Apoptosis
  
  Volume: 20 Issue: 4 Pages: 444-54
- DOI
  10.1007/s10495-014-1082-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24592841, KAKENHI-PROJECT-25460600
[Journal Article] Vaccination with OVA-bound nanoparticles enhancing IL-7 inhibits the growth of OVA-expressing E.G7 tumor cells in vivo.2015
- Author(s)
  Toyota H, Yanase N, Yoshimoto T, Harada M, Kato Y, and Mizuguchi J
- Journal Title
  
  Onco Rep
  
  Volume: 33 Issue: 1 Pages: 292-6
- DOI
  10.3892/or.2014.3603
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24592841, KAKENHI-PROJECT-26350516
[Journal Article] OVA-bound nanoparticles induce OVA-specific IgG1, IgG2a, and IgG2b responses with low IgE synthesis.2014
- Author(s)
  Yanase N, Toyota H, Yagyu S, Seki T, Harada M, Kato Y, and Mizuguchi J
- Journal Title
  
  Vaccine
  
  Volume: 32 Issue: 45 Pages: 5918-24
- DOI
  10.1016/j.vaccine.2014.08.059
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24592841, KAKENHI-PROJECT-26350516
[Journal Article] Thy28 partially prevents apoptosis induction following engagement of membrane immunoglobulin in WEHI-231 B lymphoma cells.2012
- Author(s)
  Toyota H, Jiang XZ, Asakura H, and Mizuguchi J
- Journal Title
  
  Cell Mol Biol Lett
  
  Volume: 17 Issue: 1 Pages: 36-48
- DOI
  10.2478/s11658-011-0034-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24592841
[Journal Article] Thy28 partially prevents apoptosis induction following engagement of membrane immunoglobulin in WEHI-231 B lymphoma cells2012
- Author(s)
  Toyota H, Jiang X, Asakura H, Mizuguchi J
- Journal Title
  
  Cell Mol Biol Lett
  
  Volume: 17 Pages: 36-48
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21592564
[Journal Article] Tumor necrosis factor-related apoptosis-inducing ligand induces apoptotic cell death through c-Jun NH2-teriminal kinase activation in squamous cell carcinoma cells2009
- Author(s)
  Noutomi T, Itoh M, Toyota H, Takada E, and Mizuguchi J
- Journal Title
  
  Oncol Rep
  
  Volume: 22 Pages: 1169-72
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21592564
[Journal Article] Tumor necrosis factor-related apoptosis-inducing ligand induces apoptoric cell death through c-Jun NH2-terminal kinase activation in squamous cell carcinoma cells.2009
- Author(s)
  Noutomi T, Itoh M, Toyota H, Takada E., Mizuguchi J.
- Journal Title
  
  Oncol Rep 22(5)
  
  Pages: 1169-72
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21592564
[Presentation] 分子の挙動に基づくPD-1のT細胞抑制機序の解明と免疫チェックポイント阻害抗体の効果判定への応用2025
- Author(s)
  若松英, 西航, 町山裕亮, 松島遼平, 吉田洋輔, 西川哲史, 豊田博子, 古畑昌枝, 西嶋仁, 竹内新, 鈴木実, 横須賀忠
- Organizer
  日本薬学会第145年会
- Data Source
  KAKENHI-PROJECT-24K10439
[Presentation] Indirect suppression of CD4 T cell activation through LAG-3 mediated trans-endocytosis of MHC-II2025
- Author(s)
  Ei Wakamatsu, Hiroaki Mashiyama, Hiroko Toyota, Masae Furuhata, Hitoshi Nishijima, Arata Takeuchi, Tadashi Yokosuka
- Organizer
  the USJCMSP 60th Anniversary and 25th International Conference on Emerging Infectious Diseases (EID)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24K10439
[Presentation] キメラ抗原受容体T細胞におけるリニアとパラレルのCD28共刺激シグナルの比較2024
- Author(s)
  西川哲史, 竹内新, 町山裕亮, 若松英, 西嶋仁, 古畑昌枝, 豊田博子, 西航, 松島遼平, 吉田洋輔, 横須賀忠
- Organizer
  第28回日本がん免疫学会総会・第37回日本バイオセラピィ学会学術集会総会合同大会
- Data Source
  KAKENHI-PROJECT-24K10439
[Presentation] 免疫抑制分子CD96は細胞外領域依存的にDNAM1-CD155の相互作用を阻害する2024
- Author(s)
  若松英, 服部杏, 町山裕亮, 橋本竜二, 豊田博子, 古畑昌枝, 西嶋仁, 竹内新, 横須賀忠
- Organizer
  Kyoto T cell conference 2024
- Data Source
  KAKENHI-PROJECT-24K10439
[Presentation] CD6 regulates fine-tunes T cell activation by regulating the size of TCR signalosomes through its binding to CD166.2024
- Author(s)
  Arata Takeuchi, Tetsushi Nishikawa, Hiroaki Machiyama, Ei Wakamatsu, Hitoshi Nishijima, Masae Furuhata, Hiroko Toyota, Ryohei Matsushima, Yosuke Yoshida and Tadashi Yokosuka
- Organizer
  第53回日本免疫学会
- Data Source
  KAKENHI-PROJECT-24K10439
[Presentation] Imaging of biphasic signalosomes constructed by checkpoint receptor 2B4 in conventional and CAR-T cells2024
- Author(s)
  Ryohei Matsushima, Ei Wakamatsu, Hiroaki Machiyama, Wataru Nishi, Yosuke Yoshida, Tetsushi Nishikawa, Hiroko Toyota, Masae Furuhata, Hitoshi Nishijima, Arata Takeuchi, Makoto Suzuki, Tadashi Yokosuka.
- Organizer
  第53回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-24K10439
[Presentation] Efficient inhibition of DNAM-1 clustering via sequestrating CD155 from DNAM-1-TCR microclusters by CD96 with height2024
- Author(s)
  Ei Wakamatsu, Ann Hattori, Hiroaki Machiyama, Hiroko Toyota, Ryuji Hashimoto, Hitoshi Nishijima, Arata Takeuchi, Tadashi Yokosuka.
- Organizer
  第53回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-24K10439
[Presentation] Indirect suppression of CD4+ T cell activation by LAG3-mediated trogocytosis of MHC Class II2019
- Author(s)
  Wakamatsu E, Machiyama H, Toyota H, Furuhata M, Hata K, Yanase N, Yokosuka T
- Organizer
  第48回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-16K08746
[Presentation] Extrinsic and intrinsic inhibition of T cell response by co-inhibitory receptors, TIGIT and CD962019
- Author(s)
  Yanase Noriko, Machiyama Hiroaki, Toyota Hiroko, Furuhata Masae, Hata Kikumi, Takehara Tomohiro, Wakamatsu Ei, Yokosuka Tadashi
- Organizer
  第48回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-16K08746
[Presentation] Dynamics of the PI3K signaling pathway induced by a T cell costimulator, ICOS2018
- Author(s)
  Tadashi Yokosuka, Ei Wakamatsu, Noriko Yanase, Hiroko Toyota, Masae Furuhata, Kikumi Hata, Hiroaki Machiyama
- Organizer
  第47回日本免疫学会
- Data Source
  KAKENHI-PROJECT-16K08746
[Presentation] A novel micellar nanoparticles functions as an adjuvant to enhance anti-tumor immune responses in vivo2015
- Author(s)
  Yanase Noriko、Toyota　Hiroko, , Harada　Mitsunori, Mizuguchi Junichiro, Hata Kikumi,Yokosuka Takashi
- Organizer
  第44回日本免疫学会学術集会
- Place of Presentation
  札幌市
- Year and Date
  2015-11-18
- Data Source
  KAKENHI-PROJECT-26350516
[Presentation] Thy28 regulates anti-CD3-induced thymocyte death in vivo2012
- Author(s)
  Toyota H, Yanase N, Mizuguchi J
- Organizer
  Proceedings of the Japanese Society for Immunology
- Place of Presentation
  神戸国際会議場
- Data Source
  KAKENHI-PROJECT-24592841
[Presentation] Nanoparticles function as adjuvant to enhance anti-tumor immune responses as well as humoral antibody responses in vivo.
- Author(s)
  Toyota H, Yanase N, Yoshimoto T, Harada M, and Mizuguchi J.
- Organizer
  第４３回日本免疫学会総会学術集会
- Place of Presentation
  京都
- Year and Date
  2014-12-10 – 2014-12-12
- Data Source
  KAKENHI-PROJECT-24592841
[Presentation] Nanoparticles function as adjuvant to enhance anti-tumor immune responses as well as humoral antibody responses in vivo
- Author(s)
  Toyota　Hiroko, Yanase Noriko、Yoshimoto　Takayuki , Harada　Mitsunori, Mizuguchi Junichiro
- Organizer
  第4３回日本免疫学会学術集会
- Place of Presentation
  京都市
- Year and Date
  2014-12-10 – 2014-12-12
- Data Source
  KAKENHI-PROJECT-26350516
[Presentation] ミセル化ナノ粒子によるガンワクチンの開発
- Author(s)
  矢那瀬紀子、豊田博子、秦喜久美、原田充訓、横須賀忠、水口純一郎
- Organizer
  第２６回日本生体防御学会学術総会
- Place of Presentation
  東京
- Year and Date
  2015-07-10 – 2015-07-12
- Data Source
  KAKENHI-PROJECT-26350516
[Presentation] Antigen on nanoparticles enhances anti-tumor immune responses as well as humoral antibody
- Author(s)
  Mizuguchi J, Toyota H, Yanase N, Yoshimoto T, Harada M, and Kato Y.
- Organizer
  4th International Conference on Vaccines & Vaccination
- Place of Presentation
  Valencia, Spain
- Year and Date
  2014-09-24 – 2014-09-26
- Data Source
  KAKENHI-PROJECT-24592841
[Presentation] Antigen on nanoparticles enhances anti-tumor immune responses as well as humoral antibody responses
- Author(s)
  Junichiro Mizuguchi, Hiroko Toyota, Noriko Yanase,Takayuki Yoshimoto, Mitsunori Harada, Yasuki Kato
- Organizer
  4th International Conference on Vaccines & Vaccination
- Place of Presentation
  Valencia, Spain
- Year and Date
  2014-09-24 – 2014-09-26
- Data Source
  KAKENHI-PROJECT-26350516

1. HATA Kikumi (30287156)

# of Collaborated Projects: 5 results

# of Collaborated Products: 5 results
2. YANASE Noriko (10210303)

# of Collaborated Projects: 4 results

# of Collaborated Products: 13 results
3. TAKADA Eiko (50110903)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
4. MIZUGUCHI Junichiro (20150188)

# of Collaborated Projects: 3 results

# of Collaborated Products: 14 results
5. SATOMI Takashi (70276921)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. FURUHATA Masae (90468661)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
7. CHIBA Hiroshige (80105478)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. MATSUO Akira (70229417)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. WATANABE Masato (40349460)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. KATAHIRA Takashi (20626642)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 納冨武則 (40459590)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 若松英 (40632617)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
13. 竹内新

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 横須賀忠

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results

Toyota Hiroko 豊田 博子

豊田 博子 トヨタ ヒロコ

TOYOTA Hiroko 豊田 博子

Research Projects

Research Products

Co-Researchers

抗腫瘍免疫応答における抑制性補助刺激分子LAG-3の「負」と「正」の役割の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Study of nano particle cancer vaccines targeting for Dendritic cells.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Mechanism of allergic inflammation induction of MAP kinase JNKPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Control of antigen-specific immune response by nanoparticles and elucidation of its cellular mechanism

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of inflammation in the initiation and development of oral squamous cell carcinoma

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

口腔扁平上皮癌の化学療法剤耐性及び転移能獲得における細胞死関連分子の役割

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Characterization of cancer stem cells for oral squamous cell carcinoma cells and its application for treatment of oral carcinoma

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Imaging of biphasic signalosomes constructed by checkpoint receptor 2B4 in conventional and chimeric antigen receptor-T cells2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Molecular Imaging of PD-1 Unveils Unknown Characteristics of PD-1 Itself by Visualizing “PD-1 Microclusters”2024

Author(s)

Journal Title

DOI

ISBN

Data Source

[Journal Article] Indirect suppression of CD4 T?cell activation through LAG-3-mediated trans-endocytosis of MHC class II2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The Multifaceted Role of PD-1 in Health and Disease2016

Author(s)

Journal Title

DOI

ISBN

Data Source

[Journal Article] Thy28 protects against anti-CD3-mediated thymic cell death in vivo.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Vaccination with OVA-bound nanoparticles enhancing IL-7 inhibits the growth of OVA-expressing E.G7 tumor cells in vivo.2015

Author(s)

Journal Title

DOI

Data Source

Toyota Hiroko 豊田博子

豊田博子トヨタヒロコ

TOYOTA Hiroko 豊田博子