Yoshizawa Takahiro 吉沢隆浩

… Alternative Names

YOSHIZAWA Takahiro 吉沢隆浩

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Researcher Number	40713392
Other IDs
Affiliation (Current)	2025: 信州大学, 学術研究院総合人間科学系, 助教
Affiliation (based on the past Project Information) *help	2017 – 2023: 信州大学, 学術研究院総合人間科学系, 助教 2018: 信州大学, 基盤研究支援センター, 助教 2014 – 2016: 信州大学, 学術研究院医学系, 助教
Review Section/Research Field	Principal Investigator Basic Section 53050:Dermatology-related / Cardiovascular medicine Except Principal Investigator Basic Section 47030:Pharmaceutical hygiene and biochemistry-related / Basic Section 49030:Experimental pathology-related / Basic Section 52050:Embryonic medicine and pediatrics-related / Biological pharmacy / Pediatrics
Keywords	Principal Investigator Chst14遺伝子欠損マウス / 筋拘縮型エーラス・ダンロス症候群(mcEDS) / 疾患モデル動物 / 筋拘縮型エーラス・ダンロス症候群 / エーラスダンロス症候群 / 創傷治癒 / 皮膚病変 / 筋拘縮型エーラスダンロス症候群(mcEDS) / エーラス・ダンロス症候群 / デルマタン硫酸 … More / Chst14 / 病態メカニズム解析 / 遺伝子組換えマウス / 新型エーラスダンロス症候群 / 血管異常 / 臓器保護 / アドレノメデュリン / ミトコンドリア / ドキソルビシン心筋症 / 抗がん剤の副作用軽減 … More Except Principal Investigator デルマタン硫酸 / グリコサミノグリカン / プロテオグリカン / 筋ジストロフィー / 遺伝病 / ヌクレオチダーゼ / 糖転移酵素 / ノックアウトマウス / UDP / 重症化機序 / イン・フレーム型変異 / ゲノム編集モデルマウス / ゲノム編集 / モデルマウス / BMD / 包括的病態解析 / iPS細胞 / マウスモデル / 筋拘縮型エーラス・ダンロス症候群 / 遺伝性骨・皮膚疾患 / ゴルジ体 / ゴルジン / 皮膚弛緩症 / 骨系統疾患 / コンドロイチン硫酸 / 脊椎肋骨異骨症 / 結合組織疾患 / LFNG / 免疫不全症 / 骨異形成性老人性皮膚症 / 脊椎骨端骨幹端異形成症 / エーラス・ダンロス症候群 / GORAB / Golgin / Osteopontin / Fibrosis / dystrophin / オステオポンチン / MIP-2 / MCP-1 / MMP-9 / ジストロフィン Less

Pathogenic mechanisms of hereditary neurological, immune, skeletal disorders caused by mutations in UDP metabolic enzyme
- Principal Investigator
  
  水本秀二
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Meijo University
筋拘縮型エーラス・ダンロス症候群の創傷治癒過程におけるデルマタン硫酸の役割Principal Investigator
- Principal Investigator
  
  吉沢隆浩
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53050:Dermatology-related
- Research Institution
  Shinshu University
重症度の異なるゲノム編集マウスを用いた筋ジストロフィー重症化機序に関する研究
- Principal Investigator
  
  宮崎大吾
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  Shinshu University
Development and analysis of an animal model of Musculocontractral Ehlers-Danlos syndromePrincipal Investigator
- Principal Investigator
  
  Yoshizawa Takahiro
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53050:Dermatology-related
- Research Institution
  Shinshu University
Integrated understanding of dermatan sulfate through uncovering pathophysiology of musculocontractural Ehlers-Danlos syndrome
- Principal Investigator
  
  Kosho Tomoki
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Shinshu University
Analysis of Chst14 gene-deleted mice as a model of Musculocontractural Ehlers-Danlos syndromePrincipal Investigator
- Principal Investigator
  
  Yoshizawa Takahiro
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Shinshu University
Mechanism of biosynthesis of glycosaminoglycan by Golgin, and its hereditary bone and skin disorders
- Principal Investigator
  
  Mizumoto Shuji
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Meijo University
Research of Mitochondrial Protection Reagent and Examination of the EffectPrincipal Investigator
- Principal Investigator
  
  YOSHIZAWA Takahiro
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Shinshu University
Development of the therapy for Duchenne muscular dystrophy targeting MMP-9
- Principal Investigator
  
  SHIBA Naoko
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pediatrics
- Research Institution
  Shinshu University

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 Other

All Journal Article Presentation

[Journal Article] Collagen Network Formation in In Vitro Models of Musculocontractural Ehlers Danlos Syndrome2023
- Author(s)
  Ayana Hashimoto, Takuya Hirose, Kohei Hashimoto, Shuji Mizumoto, Yuko Nitahara-Kasahara, Shota Saka, Takahiro Yoshizawa, Takashi Okada, Shuhei Yamada, Tomoki Kosh, Takafumi Watanabe, Shinji Miyata, and Yoshihiro Nomura
- Journal Title
  
  Genes
  
  Volume: 14 Issue: 2 Pages: 308-308
- DOI
  10.3390/genes14020308
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K05508, KAKENHI-PROJECT-19K08745, KAKENHI-PROJECT-22K06921
[Journal Article] Mouse Models of Musculocontractural Ehlers-Danlos Syndrome2023
- Author(s)
  Takahiro Yoshizawa, Tomoki Kosho
- Journal Title
  
  Genes
  
  Volume: 14(2) Issue: 2 Pages: 436-436
- DOI
  10.3390/genes14020436
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08745
[Journal Article] A new mouse model of Ehlers-Danlos syndrome generated using CRISPR/Cas9-mediated genomic editing.2021
- Author(s)
  Yuko Nitahara-Kasahara, Shuji Mizumoto, et al.
- Journal Title
  
  Disease Models & Mechanisms
  
  Volume: 14 Issue: 12
- DOI
  10.1242/dmm.048963
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07054, KAKENHI-PUBLICLY-19H04922, KAKENHI-PROJECT-19H03616, KAKENHI-PROJECT-19K08745, KAKENHI-PROJECT-20K06467
[Journal Article] Systematic investigation of the skin in Chst14－/－ mice: a model for skin fragility in musculocontractural Ehlers-Danlos syndrome caused by CHST14 variants (mcEDS-CHST14)2021
- Author(s)
  Takuya Hirose*, Shuji Mizumoto*, Ayana Hashimoto, Yuki Takahashi, Takahiro Yoshizawa, Yuko Nitahara-Kasahara, Naoki Takahashi, Jun Nakayama, Kazushige Takehana, Takashi Okada, Yoshihiro Nomura, Shuhei Yamada, Tomoki Kosho, Takafumi Watanabe (*equal contribution)
- Journal Title
  
  Glycobiology
  
  Volume: 31 Issue: 2 Pages: 137-150
- DOI
  10.1093/glycob/cwaa058
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07054, KAKENHI-PROJECT-19K08745, KAKENHI-PROJECT-19H03616
[Journal Article] Backcrossing to an appropriate genetic background improves the birth rate of carbohydrate sulfotransferase 14 gene-deleted mice2020
- Author(s)
  SHIMADA Shin、YOSHIZAWA Takahiro、TAKAHASHI Yuki、NITAHARA-KASAHARA Yuko、OKADA Takashi、NOMURA Yoshihiro、YAMANAKA Hitoki、KOSHO Tomoki、MATSUMOTO Kiyoshi
- Journal Title
  
  Exp. Anim.
  
  Volume: 69 Issue: 4 Pages: 407-413
- DOI
  10.1538/expanim.19-0150
- NAID
  130007938664
- ISSN
  0007-5124, 1341-1357, 1881-7122
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08745, KAKENHI-PROJECT-19H03616, KAKENHI-PROJECT-18K06019
[Journal Article] Backcrossing to an Appropriate Genetic Background Improves the Birth Rate of Carbohydrate Sulfotransferase 14 Gene-deleted Mice2020
- Author(s)
  Shin Shimada, Takahiro Yoshizawa, Yuki Takahashi, Yuko Nitahara-Kasahara, Takashi Okada, Yoshihiro Nomura, Hitoki Yamanaka, Tomoki Kosho, Kiyoshi Matsumoto
- Journal Title
  
  Experimental Animals
  
  Volume: -
- NAID
  130007938664
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K19396
[Journal Article] Backcrossing to an Appropriate Genetic Background Improves the Birth Rate of Carbohydrate Sulfotransferase 14 Gene-deleted Mice2020
- Author(s)
  Shin Shimada, Takahiro Yoshizawa, Yuki Takahashi, Yuko Nitahara-Kasahara, Takashi Okada, Yoshihiro Nomura, Hitoki Yamanaka, Tomoki Kosho, Kiyoshi Matsumoto
- Journal Title
  
  Experimental Animals
  
  Volume: -
- NAID
  130007938664
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08745
[Journal Article] Recent Advances in the Pathophysiology of Musculocontractural Ehlers-Danlos Syndrome2019
- Author(s)
  Tomoki Kosho, Shuji Mizumoto, Takafumi Watanabe, Takahiro Yoshizawa, Noriko Miyake, Shuhei Yamada
- Journal Title
  
  Genes
  
  Volume: 11 Issue: 1 Pages: 43-43
- DOI
  10.3390/genes11010043
- NAID
  120006901092
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07054, KAKENHI-PROJECT-19K08745, KAKENHI-PROJECT-19H03616, KAKENHI-PROJECT-16K19396
[Journal Article] Vascular abnormalities in the placenta of Chst14-/- fetuses: implications in the pathophysiology of perinatal lethality of the murine model and vascular lesions in human CHST14/D4ST1 deficiency2018
- Author(s)
  Takahiro Yoshizawa, Shuji Mizumoto, Yuki Takahashi, Shin Shimada, Kazuyuki Sugahara, Jun Nakayama, Shin’ichi Takeda, Yoshihiro Nomura, Yuko Nitahara-Kasahara, Takashi Okada, Kiyoshi Matsumoto, Shuhei Yamada, and Tomoki Kosho
- Journal Title
  
  Glycobiology
  
  Volume: 28 Issue: 2 Pages: 80-89
- DOI
  10.1093/glycob/cwx099
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08251, KAKENHI-PROJECT-16K19396, KAKENHI-PROJECT-15K07951
[Journal Article] Effects of Adrenomedullin on Doxorubicin-Induced Cardiac Damage in Mice2016
- Author(s)
  Takahiro Yoshizawa, Sho Takizawa, Shin Shimada, Takeshi Tokudome, Takayuki Shindo, and Kiyoshi Matsumoto
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 39 Issue: 5 Pages: 737-746
- DOI
  10.1248/bpb.b15-00832
- NAID
  130005149254
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26860551, KAKENHI-PROJECT-26293183
[Journal Article] Differential roles of MMP-9 in early and late stages of dystrophic muscles in a mouse model of Duchenne muscular dystrophy2015
- Author(s)
  Naoko Shiba, Daigo Miyazaki, Takahiro Yoshizawa, Kazuhiro Fukushima, Yuji Shiba, Yuji Inaba, Michihiro Imamura, Shin'ichi Takeda, Kenichi Koike, Akinori Nakamura
- Journal Title
  
  Biochimica et Biophysica Acta
  
  Volume: 1852 Issue: 10 Pages: 2170-2182
- DOI
  10.1016/j.bbadis.2015.07.008
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26860792, KAKENHI-PROJECT-26293182
[Presentation] Chst14 KOマウスを用いた筋拘縮型エーラス・ダンロス症候群の病態解明2023
- Author(s)
  吉沢隆浩、高橋有希、嶋田新、小野史子、岳鳳鳴、水本秀二、山中仁木、山田修平、古庄知己
- Organizer
  信州実験動物研究会第40回研究発表会
- Data Source
  KAKENHI-PROJECT-19K08745
[Presentation] 環境エンリッチメトを用いたChst14 KOマウスの出生率改善方法の検討2023
- Author(s)
  嶋田新、吉沢隆浩、岩渕忍、江﨑真司、山中仁木、古庄知己
- Organizer
  信州実験動物研究会第40回研究発表会
- Data Source
  KAKENHI-PROJECT-19K08745
[Presentation] Pathophysiological investigation on skeletal manifestations of Musculocontractural Ehlers Danlos Syndrome2023
- Author(s)
  Yuki Takahashi, Takahiro Yoshizawa, Fumiko Ono, Shuji Mizumoto, Shuhei Yamada, Tomoki Kosho
- Organizer
  Human Genetics Asia 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K07780
[Presentation] 筋拘縮型エーラス・ダンロス症候群（mcEDS）の疾患モデルマウスを用いた包括的骨病態解析2023
- Author(s)
  高橋有希、吉沢隆浩、水本秀二、小野史子、嶋田新、上原将志、渡邉敬文、山田修平、高橋淳、古庄知己
- Organizer
  第70回日本実験動物学会総会
- Data Source
  KAKENHI-PROJECT-23K07780
[Presentation] 筋拘縮型エーラス・ダンロス症候群の原因遺伝子CHST14の欠損により、Collagen XV上のデルマタン硫酸が消失する2023
- Author(s)
  橋本康平、吉沢隆浩、古庄知己、野村義宏、宮田真路
- Organizer
  第4回日本エーラス・ダンロス症候群（EDS）研究会
- Data Source
  KAKENHI-PROJECT-23K07780
[Presentation] 筋拘縮型エーラス・ダンロス症候群における脊柱変形の臨床像とモデルマウス脊椎の組織学的検討2023
- Author(s)
  上原将志、髙橋淳、高橋有希、吉沢隆浩、古庄知己
- Organizer
  第4回日本エーラス・ダンロス症候群（EDS）研究会
- Data Source
  KAKENHI-PROJECT-23K07780
[Presentation] 筋拘縮型EDSのモデルマウスによる破骨細胞分化誘導解析：骨病変の全容解明を目指して(JEFA賞授賞演題)2023
- Author(s)
  高橋有希、吉沢隆浩、小野史子、岳鳳鳴、古庄知己
- Organizer
  第4回日本エーラス・ダンロス症候群（EDS）研究会
- Data Source
  KAKENHI-PROJECT-23K07780
[Presentation] Chst14 KOマウスの出生率に対する環境エンリッチメントの効果2023
- Author(s)
  嶋田新、吉沢隆浩、岩渕忍、江崎真司、山中仁木、古庄知己
- Organizer
  第70回日本実験動物学会総会
- Data Source
  KAKENHI-PROJECT-23K07780
[Presentation] 筋拘縮型エーラスダンロス症候群の疾患モデル動物の開発と解析 (奨励賞受賞講演)2023
- Author(s)
  吉沢隆浩
- Organizer
  第70回日本実験動物学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-23K07780
[Presentation] 筋拘縮型エーラス・ダンロス症候群モデルマウスにおける大腸の解析2023
- Author(s)
  小野史子、吉沢隆浩、高橋有希、水本秀二、古庄知己
- Organizer
  第70回日本実験動物学会総会
- Data Source
  KAKENHI-PROJECT-23K07780
[Presentation] 筋拘縮型エーラス・ダンロス症候群(mcEDS)疾患モデルマウスを用いた骨病態解明への取り組み2022
- Author(s)
  高橋有希、吉沢隆浩、水本秀二、山田修平、古庄知己
- Organizer
  日本人類遺伝学会第67回大会
- Data Source
  KAKENHI-PROJECT-19K08745
[Presentation] 筋拘縮型エーラス・ダンロス症候群モデルマウスにおける大腸の解析2022
- Author(s)
  小野史子、吉沢隆浩、高橋有希、水本秀二、古庄知己
- Organizer
  第3回日本エーラス・ダンロス症候群(EDS)研究会
- Data Source
  KAKENHI-PROJECT-19K08745
[Presentation] 疾患モデルマウスを用いた筋拘縮型エーラス・ダンロス症候群の包括的骨病変解析2022
- Author(s)
  高橋有希、吉沢隆浩、水本秀二、上原将志、渡邉敬文、小野史子、嶋田新、山田修平、高橋淳、古庄知己
- Organizer
  第3回日本エーラス・ダンロス症候群(EDS)研究会
- Data Source
  KAKENHI-PROJECT-19K08745
[Presentation] Chst14 KOマウスを用いた筋拘縮型エーラス・ダンロス症候群の皮膚病態の解析と治療法探索2022
- Author(s)
  吉沢隆浩、高橋有希、小野史子、嶋田新、岳鳳鳴、水本秀二、山田修平、古庄知己
- Organizer
  第3回日本エーラス・ダンロス症候群(EDS)研究会
- Data Source
  KAKENHI-PROJECT-19K08745
[Presentation] 筋拘縮型エーラス・ダンロス症候群の疾患モデルマウス(Chst14-/-)の出生率に対するエンリッチメントの効果と繁殖用飼料の影響2022
- Author(s)
  高橋有希、吉沢隆浩、嶋田新、古庄知己
- Organizer
  信州実験動物研究会　第39回研究発表会
- Data Source
  KAKENHI-PROJECT-19H03616
[Presentation] 筋拘縮型エーラス・ダンロス症候群の疾患モデルマウス（Chst14－/－）の出生率に対するエンリッチメントの効果2021
- Author(s)
  高橋有希、吉沢隆浩、嶋田新、古庄知己
- Organizer
  第68回日本実験動物学会総会
- Data Source
  KAKENHI-PROJECT-19H03616
[Presentation] 筋拘縮型エーラス・ダンロス症候群の疾患モデルマウス（Chst14－/－）の出生率に対するエンリッチメントの効果2021
- Author(s)
  高橋有希、吉沢隆浩、嶋田新、古庄知己
- Organizer
  第68回日本実験動物学会総会
- Data Source
  KAKENHI-PROJECT-19K08745
[Presentation] Chst14遺伝子欠損マウスを用いた筋拘縮型エーラスダンロス症候群の皮膚病態モデル2021
- Author(s)
  吉沢隆浩、嶋田新、高橋有希、岳鳳鳴、山中仁木、古庄知己、松本清司
- Organizer
  第68回日本実験動物学会総会
- Data Source
  KAKENHI-PROJECT-19K08745
[Presentation] Chst14遺伝子欠損マウスを用いた筋拘縮型エーラスダンロス症候群の皮膚病態モデル2021
- Author(s)
  吉沢隆浩、嶋田新、高橋有希、岳鳳鳴、山中仁木、古庄知己、松本清司
- Organizer
  第68回日本実験動物学会総会
- Data Source
  KAKENHI-PROJECT-19H03616
[Presentation] 1歳齢の疾患モデルマウス(Chst14-/-)を用いた筋拘縮型エーラス・ダンロス症候群(mcEDS)の骨病変の解析2021
- Author(s)
  高橋有希、吉沢隆浩、水本秀二、山田修平、古庄知己
- Organizer
  日本人類遺伝学会第66回大会
- Data Source
  KAKENHI-PROJECT-19K08745
[Presentation] 1歳齢の疾患モデルマウス(Chst14-/-)を用いた筋拘縮型エーラス・ダンロス症候群(mcEDS)の骨病変の解析2021
- Author(s)
  高橋有希、吉沢隆浩、水本秀二、山田修平、古庄知己
- Organizer
  日本人類遺伝学会第66回大会
- Data Source
  KAKENHI-PROJECT-19H03616
[Presentation] 疾患モデルマウスを用いた筋拘縮型エーラス・ダンロス症候群（mcEDS）の骨病変解析2021
- Author(s)
  高橋有希、吉沢隆浩、水本秀二、山田修平、古庄知己
- Organizer
  第2回日本エーラス・ダンロス研究会
- Data Source
  KAKENHI-PROJECT-19H03616
[Presentation] 筋拘縮型エーラス・ダンロス症候群(mcEDS)の皮膚症状の疾患モデルマウスの開発2020
- Author(s)
  吉沢隆浩、高橋有希、岳鳳鳴、水本秀二、山田修平、古庄知己
- Organizer
  第1回日本エーラス・ダンロス研究会
- Data Source
  KAKENHI-PROJECT-19H03616
[Presentation] 筋拘縮型エーラス・ダンロス症候群（mcEDS）の疾患モデルマウス (Chst14-/-) を用いた骨の表現型解析2020
- Author(s)
  高橋有希、吉沢隆浩、水本秀二、山田修平、古庄知己
- Organizer
  第52回日本結合組織学術大会
- Data Source
  KAKENHI-PROJECT-19H03616
[Presentation] CRISPR/Cas9を用いて作成した筋拘縮型エーラス・ダンロス症候群モデルマウスの表現型2020
- Author(s)
  笠原優子、積田奈々、水本秀二、井上（上野）由紀子、井上高良、髙橋（中村）有希、吉沢隆浩、髙橋有希、宮田真路、山田修平、武田伸一、渡邉淳、野村義宏、古庄知己、岡田尚巳
- Organizer
  第1回日本エーラス・ダンロス研究
- Data Source
  KAKENHI-PROJECT-19H03616
[Presentation] 筋拘縮型エーラス・ダンロス症候群（mcEDS）の疾患モデルマウス（Chst14-/-）を用いた骨の表現型解析2020
- Author(s)
  高橋有希、吉沢隆浩、水本秀二、山田修平、古庄知己
- Organizer
  第1回日本エーラス・ダンロス研究
- Data Source
  KAKENHI-PROJECT-19H03616
[Presentation] 疾患モデルマウス（Chst14-/-）を用いた筋拘縮型エーラス・ダンロス症候群（mcEDS）の骨病変の解析2020
- Author(s)
  高橋有希、吉沢隆浩、水本秀二、山田修平、古庄知己
- Organizer
  日本人類遺伝学会第65回大会
- Data Source
  KAKENHI-PROJECT-19H03616
[Presentation] 筋拘縮型エーラスダンロス症候群の疾患モデル動物としてのChst14遺伝子欠損マウスの解析(Analysis of Chst14 Knockout Mice as an Animal Model of Musculocontractural Ehlers-Danlos Syndrome)2020
- Author(s)
  吉沢隆浩、嶋田新、高橋有希、水本秀二、山田修平、山中仁木、古庄知己、松本清司
- Organizer
  第67回日本実験動物学会総会
- Data Source
  KAKENHI-PROJECT-19K08745
[Presentation] 筋拘縮型エーラスダンロス症候群の疾患モデル動物としてのChst14遺伝子欠損マウスの解析2020
- Author(s)
  吉沢隆浩、嶋田新、高橋有希、水本秀二、山田修平、山中仁木、古庄知己、松本清司
- Organizer
  第67回日本実験動物学会総会
- Data Source
  KAKENHI-PROJECT-19H03616
[Presentation] Chst14遺伝子欠損マウスを用いた筋拘縮型エーラスダンロス症候群(mcEDS)の血管・皮膚症状の病態解析(Skin and Vascular Abnormalities in Chst14 Knockout Mice, an Animal Model of Musculocontractural Ehlers-Danlos Syndrome)2019
- Author(s)
  吉沢隆浩、嶋田新、高橋有希、水本秀二、山田修平、古庄知己
- Organizer
  日本人類遺伝学会 , 日本人類遺伝学会第64回大会
- Data Source
  KAKENHI-PROJECT-16K19396
[Presentation] CRISPR/Cas9-mediated development and characterization of knockout mice for musculocontractural type Ehlers-Danlos Syndrome caused by mutations in CHST14 (mcEDS-CHST14).2019
- Author(s)
  Nitahara-Kasahara Y, Tsumita N, Mizumoto S, Inoue Y, Inoue T, Yoshizawa T, Takahashi Y, Guillermo PH, Oda Y, Nakamura-Takahashi A, Hashimoto A, Nomura Y, Takeda S, Watanabe A, Kosho T, Okada T
- Organizer
  Scientific Meeting on The Rare Types of Ehlers-Danlos Syndromes
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03616
[Presentation] Skin and Vascular Abnormalities in Chst14 Gene-Deleted Mice, an Animal Model of Musculocontractual Ehlers-Danlos Syndrome2019
- Author(s)
  Takahiro Yoshizawa, Shuji Mizumoto, Yuki Takahashi, Shin Shimada, Kazuyuki Sugahara, Jun Nakayama, Shin’ichi Takeda, Yoshihiro Nomura, Yuko Nitahara-Kasahara, Takashi Okada, Kiyoshi Matsumoto, Shuhei Yamada, Tomoki Kosho
- Organizer
  The Ehlers-Danlos Society , Scientific Meeting on the Rarer Types of Ehlers-Danlos Syndromes 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08745
[Presentation] Chst14遺伝子欠損マウスを用いた筋拘縮型エーラスダンロス症候群(mcEDS)の血管・皮膚症状の病態解析2019
- Author(s)
  吉沢隆浩、嶋田新、高橋有希、水本秀二、山田修平、古庄知己
- Organizer
  日本人類遺伝学会第64回大会
- Data Source
  KAKENHI-PROJECT-19H03616
[Presentation] Skin and Vascular Abnormalities in Chst14 Gene-Deleted Mice, an Animal Model of Musculocontractual Ehlers-Danlos Syndrome2019
- Author(s)
  Takahiro Yoshizawa, Shuji Mizumoto, Yuki Takahashi, Shin Shimada, Kazuyuki Sugahara, Jun Nakayama, Shin’ichi Takeda, Yoshihiro Nomura, Yuko Nitahara-Kasahara, Takashi Okada, Kiyoshi Matsumoto, Shuhei Yamada, Tomoki Kosho
- Organizer
  The Ehlers-Danlos Society , Scientific Meeting on the Rarer Types of Ehlers-Danlos Syndromes 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19396
[Presentation] Chst14遺伝子欠損マウスを用いた筋拘縮型エーラスダンロス症候群(mcEDS)の血管・皮膚症状の病態解析(Skin and Vascular Abnormalities in Chst14 Knockout Mice, an Animal Model of Musculocontractural Ehlers-Danlos Syndrome)2019
- Author(s)
  吉沢隆浩、嶋田新、高橋有希、水本秀二、山田修平、古庄知己
- Organizer
  日本人類遺伝学会 , 日本人類遺伝学会第64回大会
- Data Source
  KAKENHI-PROJECT-19K08745
[Presentation] Skin and Vascular Abnormalities in Chst14 Gene-Deleted Mice, an Animal Model of Musculocontractual Ehlers-Danlos Syndrome2019
- Author(s)
  Yoshizawa T, Mizumoto S, Takahashi Y, Shimada S, Sugahara K, Nakayama J, Takeda S, Nomura Y, Nitahara-Kasahara Y, Okada T, Matsumoto K, Yamada S, Kosho T
- Organizer
  Scientific Meeting on The Rare Types of Ehlers-Danlos Syndromes
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03616
[Presentation] Chst14遺伝子欠損マウスの出生率改善方法の検討2018
- Author(s)
  嶋田　新、吉沢　隆浩、山中　仁木、古庄　知己、松本　清司
- Organizer
  第65回日本実験動物学会総会
- Data Source
  KAKENHI-PROJECT-16K19396
[Presentation] 遺伝背景の違いによるChst14遺伝子欠損マウスの出生率の違い2018
- Author(s)
  嶋田　新、吉沢　隆浩、松本　清司
- Organizer
  信州実験動物研究会
- Data Source
  KAKENHI-PROJECT-16K19396
[Presentation] Pathophysiological investigation of Musculocontractural Ehlers-Danlos Syndrome caused by mutations in CHST14 (mcEDS-CHST14) using knockout mice2018
- Author(s)
  Takahiro Yoshizawa, Shuji Mizumoto, Yuki Takahashi, Shin Shimada, Kazuyuki Sugahara, Jun Nakayama, Shin’ichi Takeda, Yoshihiro Nomura, Yuko Nitahara-Kasahara, Takashi Okada, Kiyoshi Matsumoto, Shuhei Yamada, Tomoki Kosho
- Organizer
  International Symposium on the Ehlers-Danlos Syndromes 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19396
[Presentation] Pathophysiological investigation of musculocontractural EDS caused by mutations in CHST14 using knock-out mice2018
- Author(s)
  Takahiro Yoshizawa, Shuji Mizumoto, Yuki Takahashi, Shin Shimada, Kazuyuki Sugahara, Jun Nakayama, Shin’ichi Takeda, Yoshihiro Nomura, Yuko Nitahara-Kasahara, Takashi Okada, Kiyoshi Matsumoto, Shuhei Yamada, Tomoki Kosho
- Organizer
  The International Symposium on the Ehlers-Danlos Syndromes (EDS2018),Ghent, Belgium, 9/28
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08251
[Presentation] CRISPR/Cas9を用いたMusculocontractural Ehlers-Danlos Syndrome-CHST14ノックアウトマウスの作製と病態解析2017
- Author(s)
  〇笠原（仁田原）優子、島津苑子、増田千明、積田奈々、水本秀二、井上(上野) 由紀子、井上高良、吉沢隆浩、高橋有希、池上良、中山淳、武田伸一、渡邉淳、古庄知己、岡田尚巳
- Organizer
  2017年度生命科学系学会合同年次大会（ConBio2017）、第40回日本分子生物学会年会、第90回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-16K08251
[Presentation] ドキソルビシン心筋症マウスに対するアドレノメデュリンの効果2016
- Author(s)
  吉沢隆浩、新藤隆行、徳留健、松本清司
- Organizer
  日本心脈管作動物質学会
- Place of Presentation
  阿波観光ホテル(徳島県)
- Year and Date
  2016-02-05
- Data Source
  KAKENHI-PROJECT-26860551
[Presentation] Pathophysiological investigation of Ehlers-Danlos syndorome caused by CHST14/D4ST1 deficiency using iPS cell and knockout mice2016
- Author(s)
  Tomoki Kosho, Nana Tsumita, Chiaki Masuda, Takahiro Yoshizawa, et al.
- Organizer
  The 13th International Congress of Human Genetics (ICHG2016)
- Place of Presentation
  京都国際会館, 京都市, 京都府
- Year and Date
  2016-04-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19396
[Presentation] デルマタン4-O-硫酸基転移酵素-1欠損に基づくエーラスダンロス症候群モデルマウスの作製および病態解析2016
- Author(s)
  ◯笠原優子、積田奈々、増田千明、島田苑子、水本秀二、井上由起子、井上高良、吉沢隆浩、中山淳、高橋有希、武田伸一、古庄知己、岡田尚巳
- Organizer
  第８９回日本生化学会大会
- Place of Presentation
  仙台国際センター・東北大学川内北キャンパス (仙台)
- Year and Date
  2016-09-26
- Data Source
  KAKENHI-PROJECT-16K08251
[Presentation] Placental phenotypes of Chst14 -/- fetal mice: a model for vascular manifestations in Ehlers-Danlos syndrome caused by CHST14/D4ST1 deficiency2016
- Author(s)
  Takahiro Yoshizawa, Shuji Mizumoto, Jun Nakayama, Takuya Hirose, Kazushige Takehana, Fengming Yue, Nana Tsumita, Chiaki Masuda, Yuko Kasahara, Yuki Takahashi, Shin-ichi Takeda, Takashi Okada, Kiyoshi Matsumoto, Tomoki Kosho
- Organizer
  The 13th International Congress of Human Genetics (ICHG2016)
- Place of Presentation
  京都国際会館, 京都市, 京都府
- Year and Date
  2016-04-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19396
[Presentation] Ablation of MMP-9 ameliorates the dystrophic phenotype by modulating chemotaxis in early stage but exacerbates fibrosis in late stage in mdx mice2015
- Author(s)
  Naoko Shiba, Daigo Miyazaki, Takahiro Yoshizawa, Kazuhiro Fukushima, Michihiro Imamura, Shin'ichi Takeda, Kenichi Koike, Akinori Nakamura
- Organizer
  20th International Congress of the World Muscle Society
- Place of Presentation
  Brighton, UK
- Year and Date
  2015-10-01
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860792
[Presentation] ジストロフィン欠損骨格筋におけるMatrix Metalloproteinase (MMP)-9の役割について2014
- Author(s)
  柴直子、宮崎大吾、福島和広、吉沢隆浩、中村昭則
- Organizer
  第9回筋ジストロフィー治療研究合同発表会
- Place of Presentation
  箱根湯元温泉吉池旅館
- Year and Date
  2014-11-01
- Data Source
  KAKENHI-PROJECT-26860792
[Presentation] ドキソルビシン心筋症モデルマウスに対するアドレノメデュリンの心保護効果
- Author(s)
  吉沢　隆浩
- Organizer
  日本毒性学会学術総会
- Place of Presentation
  石川県立音楽堂
- Year and Date
  2015-06-29 – 2015-07-01
- Data Source
  KAKENHI-PROJECT-26860551

1. Mizumoto Shuji (40443973)

# of Collaborated Projects: 5 results

# of Collaborated Products: 30 results
2. KOSHO TOMOKI (90276311)

# of Collaborated Projects: 4 results

# of Collaborated Products: 39 results
3. NAKAMURA Akinori (10303471)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
4. MIYAZAKI Daigo (80596370)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
5. YAMADA SHUHEI (70240017)

# of Collaborated Projects: 2 results

# of Collaborated Products: 12 results
6. MIYAKE NORIKO (40523494)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. 岳鳳鳴 (20532865)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
8. SHIBA Naoko (00639289)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
9. FUKUSHIMA Kazuhiro (10421835)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
10. SUGAHARA KAZUYUKI (60154449)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
11. IKEGAWA SHIRO (30272496)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. MATSUMOTO NAOMICHI (80325638)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
13. 角田佳充 (00314360)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 岡田尚巳 (00326828)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 野村義宏 (10228372)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
16. 松本健一 (30202328)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
17. 上原将志 (30748108)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 渡邉敬文 (50598216)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
19. 高橋淳 (60345741)

# of Collaborated Projects: 1 results

# of Collaborated Products: 13 results
20. 宮田真路 (60533792)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
21. 高野亨子 (70392420)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 笠原優子 (90391911)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
23. 山口智美 (90802835)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 林正徳 (20624703)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. Janecke Andreas

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. Vodopiutz Julia

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. Kornak Uwe

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. 岡田尚已

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results

Yoshizawa Takahiro 吉沢 隆浩

YOSHIZAWA Takahiro 吉沢 隆浩

Research Projects

Research Products

Co-Researchers

Pathogenic mechanisms of hereditary neurological, immune, skeletal disorders caused by mutations in UDP metabolic enzyme

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筋拘縮型エーラス・ダンロス症候群の創傷治癒過程におけるデルマタン硫酸の役割Principal Investigator

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重症度の異なるゲノム編集マウスを用いた筋ジストロフィー重症化機序に関する研究

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Development and analysis of an animal model of Musculocontractral Ehlers-Danlos syndromePrincipal Investigator

Principal Investigator

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Integrated understanding of dermatan sulfate through uncovering pathophysiology of musculocontractural Ehlers-Danlos syndrome

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Analysis of Chst14 gene-deleted mice as a model of Musculocontractural Ehlers-Danlos syndromePrincipal Investigator

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Mechanism of biosynthesis of glycosaminoglycan by Golgin, and its hereditary bone and skin disorders

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Research of Mitochondrial Protection Reagent and Examination of the EffectPrincipal Investigator

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Development of the therapy for Duchenne muscular dystrophy targeting MMP-9

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[Journal Article] Collagen Network Formation in In Vitro Models of Musculocontractural Ehlers Danlos Syndrome2023

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DOI

Data Source

[Journal Article] Mouse Models of Musculocontractural Ehlers-Danlos Syndrome2023

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Data Source

[Journal Article] A new mouse model of Ehlers-Danlos syndrome generated using CRISPR/Cas9-mediated genomic editing.2021

Author(s)

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[Journal Article] Systematic investigation of the skin in Chst14－/－ mice: a model for skin fragility in musculocontractural Ehlers-Danlos syndrome caused by CHST14 variants (mcEDS-CHST14)2021

Author(s)

Journal Title

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[Journal Article] Backcrossing to an appropriate genetic background improves the birth rate of carbohydrate sulfotransferase 14 gene-deleted mice2020

Yoshizawa Takahiro 吉沢隆浩

YOSHIZAWA Takahiro 吉沢隆浩