yamaguchi takehiro 山口雄大

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Yamaguchi Takehiro 山口雄大

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Researcher Number	40726080
Other IDs	https://orcid.org/0000-0002-5965-6499
Affiliation (Current)	2025: 国立健康危機管理研究機構, 国立感染症研究所細菌第一部, 主任研究員
Affiliation (based on the past Project Information) *help	2021 – 2024: 国立感染症研究所, 細菌第一部, 主任研究官 2022: 大阪公立大学, 大学院医学研究科, 医員 2021: 国立感染症研究所, 細菌第一部第六室, 主任研究官 2019 – 2020: 大阪市立大学, 大学院医学研究科, 助教 2017: 大阪市立大学, 大学院医学研究科, 助教 2016: 新潟大学, 医歯学総合研究科, 特任助教 2015: 大阪市立大学, 医学(系)研究科(研究院), その他
Review Section/Research Field	Principal Investigator Basic Section 57080:Social dentistry-related / Basic Section 49050:Bacteriology-related / Infectious disease medicine / Cardiovascular medicine Except Principal Investigator Medium-sized Section 57:Oral science and related fields / Basic Section 52010:General internal medicine-related
Keywords	Principal Investigator 心不全 / 外膜小胞 / 歯周病 / 宿主内潜伏 / BCG / メンブレンヴェシクル / 結核 / 潜在性結核 / 感染症 / 血清マーカー / 高齢者結核 … More Except Principal Investigator … More 粘膜免疫 / ワクチン / 歯周病 / 細菌膜小胞 / 細菌由来膜小胞 / 膜小胞 / 老化 / 遺伝子検査学 / 血管内皮機能 / 早期血管障害 / 喫煙 / circulating microRNA / endothelial dysfunction / smoking Less

Elucidation of molecular mechanisms in development of periodontal disease-associated heart failurePrincipal Investigator
- Principal Investigator
  
  山口雄大
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57080:Social dentistry-related
- Research Institution
  National Institute of Infectious Diseases
Acceleration of unexplored periodontal disease vaccine development by intranasal administration of bacterial membrane vesicles
- Principal Investigator
  
  中尾龍馬
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 57:Oral science and related fields
- Research Institution
  National Institute of Infectious Diseases
Circulating microRNAs associated with smoking-induced vascular endothelial dysfunction
- Principal Investigator
  
  Yasuhiko Takeoto
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Osaka Metropolitan University
  Osaka City University
Elucidation of Molecular Mechanism of Mycobacterial Latency via Mycobacterial Membrane VesiclesPrincipal Investigator
- Principal Investigator
  
  Yamaguchi Takehiro
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 49050:Bacteriology-related
- Research Institution
  National Institute of Infectious Diseases
  Osaka City University
Identification of a novel anti-mycobacterial agent in human serumPrincipal Investigator
- Principal Investigator
  
  Yamaguchi Takehiro
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Infectious disease medicine
- Research Institution
  Osaka City University
  Niigata University
四肢の虚血コンディショニングは拡張性心不全の新規治療法となりうるか？Principal Investigator
- Principal Investigator
  
  山口雄大
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Osaka City University

All 2024 2023 2022 2021 2020 2019 2017 2016

All Journal Article Presentation

[Journal Article] Mucosal adjuvanticity and mucosal booster effect of colibactin-depleted probiotic <i>Escherichia coli</i> membrane vesicles2024
- Author(s)
  Uchiyama Hiroki、Kudo Toshifumi、Yamaguchi Takehiro、Obana Nozomu、Watanabe Kenji、Abe Kimihiro、Miyazaki Hidetaka、Toyofuku Masanori、Nomura Nobuhiko、Akeda Yukihiro、Nakao Ryoma
- Journal Title
  
  Human Vaccines & Immunotherapeutics
  
  Volume: 20 Issue: 1 Pages: 2337987-2337987
- DOI
  10.1080/21645515.2024.2337987
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K18284, KAKENHI-PROJECT-21KK0164, KAKENHI-PROJECT-22K05400, KAKENHI-PROJECT-20H03861, KAKENHI-PROJECT-23K26811
[Journal Article] Escherichia coli-Derived Outer Membrane Vesicles Relay Inflammatory Responses to Macrophage-Derived Exosomes2023
- Author(s)
  Imamiya Risa、Shinohara Akari、Yakura Daisuke、Yamaguchi Takehiro、Ueda Koji、Oguro Ami、Minamiyama Yukiko、Ichikawa Hiroshi、Horiguchi Yasuhiko、Osada-Oka Mayuko
- Journal Title
  
  mBio
  
  Volume: 14 Issue: 1
- DOI
  10.1128/mbio.03051-22
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K19378, KAKENHI-PROJECT-20K07481, KAKENHI-PROJECT-19K16651, KAKENHI-PROJECT-23K21392
[Journal Article] A bivalent outer membrane vesicle-based intranasal vaccine to prevent infection of periodontopathic bacteria2023
- Author(s)
  Nakao Ryoma、Hirayama Satoru、Yamaguchi Takehiro、Senpuku Hidenobu、Hasegawa Hideki、Suzuki Tadaki、Akeda Yukihiro、Ohnishi Makoto
- Journal Title
  
  Vaccine
  
  Volume: 41 Issue: 30 Pages: 4369-4383
- DOI
  10.1016/j.vaccine.2023.05.058
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K18284, KAKENHI-PROJECT-21KK0164
[Journal Article] Augmented O-GlcNAcylation exacerbates right ventricular dysfunction and remodeling via enhancement of hypertrophy, mitophagy, and fibrosis in mice exposed to long-term intermittent hypoxia2022
- Author(s)
  Yokoe Shunichi、Hayashi Tetsuya、Nakagawa Takatoshi、Kato Ryuji、Ijiri Yoshio、Yamaguchi Takehiro、Izumi Yasukatsu、Yoshiyama Minoru、Asahi Michio
- Journal Title
  
  Hypertension Research
  
  Volume: 46 Issue: 3 Pages: 667-678
- DOI
  10.1038/s41440-022-01088-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07943, KAKENHI-PROJECT-20K11352, KAKENHI-PROJECT-19K16651
[Journal Article] Direct attachment with erythrocytes augments extracellular growth of pathogenic Mycobacteria2022
- Author(s)
  Nishiuchi, Y., Tateishi, Y., Hirano, H., Ozeki, Y., Yamaguchi, T., Miki, M., Kitada, S., Maruyama, F., Matsumoto, S.
- Journal Title
  
  Microbiology Spectrum
  
  Volume: in press Issue: 2
- DOI
  10.1128/spectrum.02454-21
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08629, KAKENHI-PROJECT-21K19637, KAKENHI-PROJECT-20KK0216, KAKENHI-PROJECT-19K16651
[Journal Article] Lysocin E Targeting Menaquinone in the Membrane of Mycobacterium tuberculosis Is a Promising Lead Compound for Antituberculosis Drugs2022
- Author(s)
  Geberetsadik G, Inaizumi A, Nishiyama A, Yamaguchi T, Hamamoto H, Panthee S, Tamaru A, Hayatsu M, Mizutani Y, Kaboso SA, Hakamata M, Ilinov A, Ozeki Y, Tateishi Y, Sekimizu K, Matsumoto S.
- Journal Title
  
  Antimicrob Agents Chemother
  
  Volume: 66 Issue: 9
- DOI
  10.1128/aac.00171-22
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K19637, KAKENHI-PROJECT-19K16651, KAKENHI-PROJECT-20KK0216, KAKENHI-PROJECT-23K24374, KAKENHI-PROJECT-21H02733
[Journal Article] An efficient CRISPR interference-based prediction method for synergistic/additive effects of novel combinations of anti-tuberculosis drugs2022
- Author(s)
  Samukawa Noriaki、Yamaguchi Takehiro、Ozeki Yuriko、Matsumoto Sohkichi、Igarashi Masayuki、Kinoshita Naoko、Hatano Masaki、Tokudome Kentaro、Matsunaga Shinji、Tomita Shuhei
- Journal Title
  
  Microbiology
  
  Volume: 168 Issue: 12 Pages: 1-11
- DOI
  10.1099/mic.0.001285
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07943, KAKENHI-PROJECT-20K07072
[Journal Article] Rivaroxaban Attenuates Right Ventricular Remodeling in Rats with Pulmonary Arterial Hypertension2021
- Author(s)
  Imano Hideki、Kato Ryuji、Nomura Atsuo、Tamura Maki、Yamaguchi Yudai、Ijiri Yoshio、Wu Hong、Nakano Takashi、Okada Yoshikatsu、Yamaguchi Takehiro、Izumi Yasukatsu、Yoshiyama Minoru、Asahi Michio、Hayashi Tetsuya
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 44 Issue: 5 Pages: 669-677
- DOI
  10.1248/bpb.b20-01011
- NAID
  130008033192
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2021-05-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16651, KAKENHI-PROJECT-19K07943
[Journal Article] Effects of orally active hypoxia inducible factor alpha prolyl hydroxylase inhibitor, FG4592 on renal fibrogenic potential in mouse unilateral ureteral obstruction model2020
- Author(s)
  Kabei Kazuya、Tateishi Yu、Shiota Masayuki、Osada-Oka Mayuko、Nishide Shunji、Uchida Junji、Nakatani Tatsuya、Matsunaga Shinji、Yamaguchi Takehiro、Tomita Shuhei、Miura Katsuyuki
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 142 Issue: 3 Pages: 93-100
- DOI
  10.1016/j.jphs.2019.12.002
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07943, KAKENHI-PROJECT-19K16651, KAKENHI-PROJECT-17K08836, KAKENHI-PROJECT-17K08958, KAKENHI-PROJECT-20K07072, KAKENHI-PROJECT-17K08602
[Journal Article] Protease-Activated Receptor-1 Inhibition by FR171113 Attenuates Cardiac Remodeling Due to Intermittent Hypoxia2020
- Author(s)
  Hayashi, T., H. Imano, R. Kato, Y. Ijiri, T. Yamaguchi, Y. Izumi, A. Nomura, and M. Yoshiyama.
- Journal Title
  
  Ann Cardiol Vasc Med
  
  Volume: 3 Pages: 1036-1041
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16651
[Journal Article] Soluble urokinase-type plasminogen activator receptor represents exercise tolerance and predicts adverse cardiac events in patients with heart failure2020
- Author(s)
  Ishikawa H, Izumiya Y, Shibata A, Ichikawa Y, Yamaguchi T, Yamaguchi Y, Kitada R, Iwata S, Ehara S, Tomita S, Hanatani A, Yoshiyama M.
- Journal Title
  
  Heart Vessels.
  
  Volume: 35 Issue: 5 Pages: 681-688
- DOI
  10.1007/s00380-019-01538-3
- URL
  https://ocu-omu.repo.nii.ac.jp/records/2019871
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08493, KAKENHI-PROJECT-19K16651, KAKENHI-PROJECT-19K07943, KAKENHI-PROJECT-17K08602
[Journal Article] Prolyl-hydroxylase inhibitors reconstitute tumor blood vessels in mice2020
- Author(s)
  Nishide Shunji、Uchida Junji、Matsunaga Shinji、Tokudome Kentaro、Yamaguchi Takehiro、Kabei Kazuya、Moriya Taiki、Miura Katsuyuki、Nakatani Tatsuya、Tomita Shuhei
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 143 Issue: 2 Pages: 122-126
- DOI
  10.1016/j.jphs.2020.02.010
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K14598, KAKENHI-PROJECT-19K16651, KAKENHI-PROJECT-19K18594, KAKENHI-PROJECT-17K08958, KAKENHI-PROJECT-20K07072, KAKENHI-PROJECT-17K08602
[Journal Article] Augmented O-GlcNAcylation attenuates intermittent hypoxia-induced cardiac remodeling through the suppression of NFAT and NF-κB activities in mice2019
- Author(s)
  Nakagawa Takatoshi、Furukawa Yuichi、Hayashi Tetsuya、Nomura Atsuo、Yokoe Shunichi、Moriwaki Kazumasa、Kato Ryuji、Ijiri Yoshio、Yamaguchi Takehiro、Izumi Yasukatsu、Yoshiyama Minoru、Asahi Michio
- Journal Title
  
  Hypertension Research
  
  Volume: 42 Issue: 12 Pages: 1858-1871
- DOI
  10.1038/s41440-019-0311-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16651
[Journal Article] Controlling the Phenotype of Tumor-Infiltrating Macrophages via the PHD-HIF Axis Inhibits Tumor Growth in a Mouse Model2019
- Author(s)
  Nishide Shunji、Matsunaga Shinji、Shiota Masayuki、Yamaguchi Takehiro、Kitajima Shojiro、Maekawa Yoichi、Takeda Norihiko、Tomura Michio、Uchida Junji、Miura Katsuyuki、Nakatani Tatsuya、Tomita Shuhei
- Journal Title
  
  iScience
  
  Volume: 19 Pages: 940-954
- DOI
  10.1016/j.isci.2019.08.033
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16651, KAKENHI-PROJECT-19K18594, KAKENHI-PROJECT-17K08958
[Journal Article] Metabolic adaptation to glycolysis is a basic defense mechanism of macrophages for Mycobacterium tuberculosis infection2019
- Author(s)
  Osada-Oka Mayuko、Goda Nobuhito、Saiga Hiroyuki、Yamamoto Masahiro、Takeda Kiyoshi、Ozeki Yuriko、Yamaguchi Takehiro、Soga Tomoyoshi、Tateishi Yu、Miura Katsuyuki、Okuzaki Daisuke、Kobayashi Kazuo、Matsumoto Sohkichi
- Journal Title
  
  International Immunology
  
  Volume: 31 Issue: 12 Pages: 781-793
- DOI
  10.1093/intimm/dxz048
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16651, KAKENHI-PROJECT-17K08836, KAKENHI-PROJECT-17K08958
[Journal Article] Capillary Degeneration and Right Ventricular Remodeling Due to Hypoxic Stress with Sugen54162017
- Author(s)
  Woo Eiki、Kato Ryuji、Imano Hideki、Fujiwara Yuji、Ijiri Yoshio、Okada Yoshikatsu、Yamaguchi Takehiro、Izumi Yasukatsu、Yoshiyama Minoru、Katsumata Takahiro、Hayashi Tetsuya
- Journal Title
  
  Current Vascular Pharmacology
  
  Volume: 15 Issue: 6 Pages: 589-598
- DOI
  10.2174/1570161115666170427154217
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08649, KAKENHI-PROJECT-16K21044
[Journal Article] Mycobacterial DNA-binding protein 1 is critical for long term survival of Mycobacterium smegmatis and simultaneously coordinates cellular functions.2017
- Author(s)
  Enany S, Yoshida Y, Tateishi Y, Ozeki Y, Nishiyama A, Savitskaya A, Yamaguchi T, Ohara Y, Yamamoto T, Ato M, Matsumoto S.
- Journal Title
  
  Sci Rep
  
  Volume: 7 Issue: 1 Pages: 6810-6810
- DOI
  10.1038/s41598-017-06480-w
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08774, KAKENHI-PROJECT-17K08823, KAKENHI-PROJECT-16K21044
[Journal Article] Hypoxia-inducible factor-1α promotes cell survival during ammonia stress response in ovarian cancer stem-like cells.2017
- Author(s)
  Kitajima S, Lee KL, Hikasa H, Sun W, Huang RY, Yang H, Matsunaga S, Yamaguchi T, Araki M, Kato H, Poellinger L
- Journal Title
  
  Oncotarget.
  
  Volume: 8 Issue: 70 Pages: 114481-114494
- DOI
  10.18632/oncotarget.23010
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07052, KAKENHI-PROJECT-16K21044
[Journal Article] Macrophage-derived exosomes induce inflammatory factors in endothelial cells under hypertensive conditions.2017
- Author(s)
  Osada-Oka M, Shiota M, Izumi Y, Nishiyama M, Tanaka M, Yamaguchi T, Sakurai E, Miura K, Iwao H.
- Journal Title
  
  Hypertens Res
  
  Volume: 40 Issue: 4 Pages: 353-360
- DOI
  10.1038/hr.2016.163
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460344, KAKENHI-PROJECT-15K15132, KAKENHI-PROJECT-16K21044
[Presentation] Fate of Porphyromonas ginigivalis outer membrane vesicles intravesously administered to mice2023
- Author(s)
  内山大樹、山口雄大、宮崎英隆、明田宏幸、中尾龍馬
- Organizer
  第96回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-21K18284
[Presentation] ウシ型結核菌弱毒株BCG由来メンブレンヴェシクルを用いた新規結核ワクチン開発2023
- Author(s)
  山口雄大、寒川訓明、中尾龍馬、明田幸宏
- Organizer
  第96回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-21K18284
[Presentation] Effect of hypoxia-inducible factors in tumor infiltrating macrophage on tumor growth2022
- Author(s)
  Matsunaga Shinji、Yamaguchi Kazuyuki、Hirakawa Ryo、Tokudome Kentaro、Yamaguchi Takehiro、Tomita Shuhei
- Organizer
  第95回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-19K16651
[Presentation] Fetal hypoxia caused decrease of gliogenesis-related gene expression in rat2022
- Author(s)
  Tokudome Kentaro、Ueki Masaaki、Nakamura Atsuki、Yamaguchi Takehiro、Matsunaga Shinji、Tomita Shuhei
- Organizer
  第95回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-19K16651
[Presentation] BCG由来細胞外膜小胞の新規結核ワクチンへの応用2022
- Author(s)
  山口雄大、寒川訓明、中尾龍馬、明田幸宏
- Organizer
  第26回日本ワクチン学会学術総会
- Data Source
  KAKENHI-PROJECT-19K16651
[Presentation] ウシ型結核菌弱毒株BCG由来メンブレンヴェシクルを用いた新規結核ワクチン開発2022
- Author(s)
  山口雄大、寒川訓明、中尾龍馬、明田幸宏
- Organizer
  第96回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-19K16651
[Presentation] マウスにおけるPorphyromonas gingivalis 由来外膜小胞の血行動態について2022
- Author(s)
  内山大樹、宮崎英隆、山口雄大、中尾龍馬
- Organizer
  第64回歯科基礎医学会
- Data Source
  KAKENHI-PROJECT-21K18284
[Presentation] 歯周病ワクチンの研究：細菌由来外膜小胞による優れた粘膜免疫原性の活用2022
- Author(s)
  中尾龍馬、山口雄大、石原和幸、明田幸宏
- Organizer
  第26回日本ワクチン学会学術総会
- Data Source
  KAKENHI-PROJECT-19K16651
[Presentation] Lysocin E targeting menaquinone is a promising lead compound for anti-tuberculosis drugs2022
- Author(s)
  Gebremichal Gebretsadik、稲泉茜、西山晃史、山口雄大、浜本洋、田丸亜貴、早津学、Amina Shaban、尾関百合子、松本壮吉
- Organizer
  第96回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-19K16651
[Presentation] BCG 由来細胞外小胞の新規結核ワクチンへの応用2022
- Author(s)
  山口雄大、寒川訓明、中尾龍馬、明田幸宏
- Organizer
  第26回日本ワクチン学会
- Data Source
  KAKENHI-PROJECT-21K18284
[Presentation] 非結核性抗酸菌に対する紅参由来サポニンの抗菌作用の機序解明2022
- Author(s)
  寒川訓明、山口雄大、徳留健太郎、本間拓二郎、松永慎司、冨田修平
- Organizer
  第96回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-19K16651
[Presentation] 抗酸菌のプロテアーゼclpは有望な新規抗結核薬標的である2022
- Author(s)
  山口雄大、寒川訓明、尾関百合子、松本壮吉、冨田修平
- Organizer
  第95回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-19K16651
[Presentation] CRISPR Interference-based Screening for Prediction of Synergistic/Additive Effects of Novel Combinations of Anti-Tuberculosis Drugs2022
- Author(s)
  Samukawa Noriaki、Yamaguchi Takehiro、Ozeki Yuriko、Matsumoto Sohkichi、Tokudome Kentaro、Matsunaga Shinji、Tomita Shuhei
- Organizer
  第95回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-19K16651
[Presentation] Fate of Porphyromonas gingivalis outer membrane vesicles intravenously administered to mice2022
- Author(s)
  内山大樹、山口雄大、宮崎英隆、明田幸宏、中尾龍馬
- Organizer
  第96回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-19K16651
[Presentation] 歯周病ワクチンの研究:細菌由来外膜小胞による優れた粘膜免疫原性の活用2022
- Author(s)
  中尾龍馬、山口雄大、石原和幸、明田幸宏
- Organizer
  第26回日本ワクチン学会
- Data Source
  KAKENHI-PROJECT-21K18284
[Presentation] Inactivation of DNA function by intrinsically disordered histone-like protein in mycobacteria2022
- Author(s)
  西山晃史、古寺哲幸、清水将裕、Anna Savitskaya、尾関百合子、真柳浩太、山口雄大、立石善隆、松本壮吉
- Organizer
  第95回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-19K16651
[Presentation] 抗酸菌のプロテアーゼclpは創薬標的として有望である2021
- Author(s)
  山口雄大、尾関百合子、松本壮吉、徳留健太郎、松永慎司、冨田修平
- Organizer
  第94回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-19K16651
[Presentation] Development of anti-TB vaccine using mycobacterial membrane vesicles2021
- Author(s)
  Yamaguchi Takehiro、Samukawa Noriaki、Nakao Ryoma、Tomita Shuhei
- Organizer
  EMBO Workshop Bacterial membrane vesicles
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16651
[Presentation] Development of anti-TB vaccine using mycobacterial membrane vesicles2021
- Author(s)
  Takehiro Yamaguchi, Noriaki Samukawa, Ryoma Nakao and Shuhei Tomita
- Organizer
  EMBO Workshop: Bacterial Membrane Vesicles: Biogenesis, functions, and medical applications
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K18284
[Presentation] 低酸素休眠抗酸菌の腫瘍タンパク質Mycobacterial DNA-binding protein 12021
- Author(s)
  西山晃史、古寺哲幸、清水将裕、Anna Savitskaya、Shymaa Enany、真柳浩太、山口雄大、尾関百合子、立石善隆、松本壮吉
- Organizer
  第94回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-19K16651
[Presentation] 発達期の低酸素状態は脳内の発達障害関連部位においてアストロサイトを低下させる2021
- Author(s)
  徳留健太郎、植木正明、山口雄大、松永慎司、冨田修平
- Organizer
  第94回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-19K16651
[Presentation] BCG由来メンブレンヴェシクルを用いた結核ワクチン開発研究2021
- Author(s)
  山口雄大、中尾龍馬、冨田修平
- Organizer
  第94回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-19K16651
[Presentation] 腫瘍血管形成に対するPHD阻害薬の効果検討2021
- Author(s)
  松永慎司、山口一行、徳留健太郎、山口雄大、冨田修平
- Organizer
  第94回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-19K16651
[Presentation] Exploring the Role of Mycobacterial Membrane Vesicles toward Vaccine Development2019
- Author(s)
  山口雄大
- Organizer
  日本細菌学会
- Data Source
  KAKENHI-PROJECT-19K16651
[Presentation] Analysis of the Host Immune Response against Mycobacterial Membrane Vesicles2019
- Author(s)
  山口雄大, 冨田修平
- Organizer
  日本細菌学会
- Data Source
  KAKENHI-PROJECT-19K16651
[Presentation] 遅延型過敏反応から検討した MDP1 および G9.1 からなる結核ブースターワクチン候補の免疫条件2017
- Author(s)
  前山順一, 山崎利雄, 林大介, 山本十糸子, 尾関百合子, 鈴木史子, 山口雄大, 松本壮吉, 伊保澄子, 山本三郎
- Organizer
  日本細菌学会
- Place of Presentation
  仙台国際センター展示棟（宮城県仙台市）
- Year and Date
  2017-03-19
- Data Source
  KAKENHI-PROJECT-16K21044
[Presentation] 抗酸菌の長期の生存に必須な細胞機能のヒストン様タンパク質依存的な制御2017
- Author(s)
  西山晃史, Shymaa Enany, 立石善隆, 尾関百合子, Anna G. Savitskaya, 山口雄大, 西田由貴子, 阿戸学, 松本壮吉
- Organizer
  日本細菌学会
- Place of Presentation
  仙台国際センター展示棟（宮城県仙台市）
- Year and Date
  2017-03-19
- Data Source
  KAKENHI-PROJECT-16K21044
[Presentation] 遠隔臓器の一過性虚血コンディショニングは心筋梗塞慢性期の心リモデリングを抑制する2017
- Author(s)
  山口雄大
- Organizer
  日本循環薬理学会
- Data Source
  KAKENHI-PROJECT-16K21044
[Presentation] RIVAROXABAN ATTENUATES CARDIAC REMODELING DUE TO INTERMITTENT HYPOXIA BY SUPPRESSING THE SYNERGISTIC EFFECTS OF PAR-1 AND PAR-22017
- Author(s)
  Rintaro Mitsuishi, Hideki Imano, Ryuji Kato, Yoshio Ijiri, Takehiro Yamaguchi, Minoru Yoshiyama, Tetsuya Hayashi
- Organizer
  American College of Cardiology 2017, 66th Annual Scietific Session & Expo
- Place of Presentation
  ワシントンD.C.（アメリカ）
- Year and Date
  2017-03-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K21044
[Presentation] 心血管リモデリングにエキソソームが果たす役割2017
- Author(s)
  山口雄大
- Organizer
  日本循環制御医学会
- Invited
- Data Source
  KAKENHI-PROJECT-16K21044
[Presentation] Rivaroxaban, but Not PAR-2 Antagonist, Attenuates Cardiac Remodeling Due to Intermittent Hypoxia in Sleep Apnea Model Mice2016
- Author(s)
  Saki Morita, Ayumi Fujiwara, Toshiki Kondo, Kenji Fujii, Hideki Imano, Ryuji Kato, Yoshio Ijiri, Takehiro Yamaguchi, Yasukatsu Izumi, Minoru Yoshiyama, Tetsuya Hayashi
- Organizer
  American Heart Association Scientific Sessions 2016
- Place of Presentation
  ニューオリンズ（アメリカ）
- Year and Date
  2016-11-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K21044
[Presentation] Rivaroxaban Attenuates Diastolic Dysfunction and Cardiovascular Remodeling Induced by Intermittent Hypoxia in Mice2016
- Author(s)
  Toshiki Kondo, Ayumi Fujiwara, Kaoru Shimada, Kenji Fujii, Hideki Imano, Ryuji Kato, Yoshio Ijiri, Takehiro Yamaguchi, Minoru Yoshiyama, Tetsuya Hayashi
- Organizer
  日本心不全学会
- Place of Presentation
  ロイトン札幌・ホテルさっぽろ芸文館（北海道札幌市）
- Year and Date
  2016-10-07
- Data Source
  KAKENHI-PROJECT-16K21044
[Presentation] Macrophage-derived exosomes under hypertensive conditions cause inflammation in endothelial cells2016
- Author(s)
  Yasukatsu Izumi, Takehiro Yamaguchi, Mayuko Osada-Oka, Masayuki Shiota, M Tanaka, Katsuyuki Miura, Shuhei Tomita, Hiroshi Iwao
- Organizer
  European Society of Cardiology Congress 2016
- Place of Presentation
  ローマ（イタリア）
- Year and Date
  2016-08-27
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K21044

1. Yasuhiko Takeoto (20364002)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 冨田修平 (00263898)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 首藤太一 (20295687)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 葭山稔 (30240956)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
5. 福本一夫 (20897392)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 塩田正之 (30381990)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. 中尾龍馬 (10370959)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
8. 相内章 (10572133)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 泉福英信 (20250186)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. 佐々木永太 (40762216)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 野村暢彦 (60292520)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. 井上智 (90213157)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. OZEKI Yuriko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. MORIYA Taiki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 堀口安彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 日笠弘基

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 西内由紀子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 富田修平

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
19. 泉康雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

yamaguchi takehiro 山口 雄大

Yamaguchi Takehiro 山口 雄大

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Elucidation of molecular mechanisms in development of periodontal disease-associated heart failurePrincipal Investigator

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Acceleration of unexplored periodontal disease vaccine development by intranasal administration of bacterial membrane vesicles

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Circulating microRNAs associated with smoking-induced vascular endothelial dysfunction

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Elucidation of Molecular Mechanism of Mycobacterial Latency via Mycobacterial Membrane VesiclesPrincipal Investigator

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Identification of a novel anti-mycobacterial agent in human serumPrincipal Investigator

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四肢の虚血コンディショニングは拡張性心不全の新規治療法となりうるか？Principal Investigator

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[Journal Article] Mucosal adjuvanticity and mucosal booster effect of colibactin-depleted probiotic <i>Escherichia coli</i> membrane vesicles2024

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[Journal Article] Escherichia coli-Derived Outer Membrane Vesicles Relay Inflammatory Responses to Macrophage-Derived Exosomes2023

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[Journal Article] A bivalent outer membrane vesicle-based intranasal vaccine to prevent infection of periodontopathic bacteria2023

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[Journal Article] Augmented O-GlcNAcylation exacerbates right ventricular dysfunction and remodeling via enhancement of hypertrophy, mitophagy, and fibrosis in mice exposed to long-term intermittent hypoxia2022

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[Journal Article] Direct attachment with erythrocytes augments extracellular growth of pathogenic Mycobacteria2022

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[Journal Article] Lysocin E Targeting Menaquinone in the Membrane of Mycobacterium tuberculosis Is a Promising Lead Compound for Antituberculosis Drugs2022

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[Journal Article] An efficient CRISPR interference-based prediction method for synergistic/additive effects of novel combinations of anti-tuberculosis drugs2022

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[Journal Article] Rivaroxaban Attenuates Right Ventricular Remodeling in Rats with Pulmonary Arterial Hypertension2021

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yamaguchi takehiro 山口雄大

Yamaguchi Takehiro 山口雄大