Ueda Keisuke 植田圭祐

Researcher Number	40755972
Other IDs
Affiliation (Current)	2025: 千葉大学, 大学院薬学研究院, 助教
Affiliation (based on the past Project Information) *help	2016 – 2025: 千葉大学, 大学院薬学研究院, 助教
Review Section/Research Field	Principal Investigator Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related / Physical pharmacy Except Principal Investigator Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related / Physical pharmacy
Keywords	Principal Investigator NMR / 液-液相分離 / 過飽和 / ナノ粒子 / 固体NMR / 非晶質 / Cryo-TEM / 脂質ナノ粒子 / 薬物濃縮相 / 液液相分離 … More / 相分離 / 溶出試験 / 非晶質溶解度 / 分子間相互作用 / 液－液相分離 / 固体分散体 / 経口吸収改善 / 薬物ナノ粒子 / 非晶質固体分散体 / 薬物ナノ結晶 / 製剤 / 難水溶性薬物 / 緩和時間測定 / ナノ結晶 / 混合粉砕 … More Except Principal Investigator 安定性 / 難水溶性薬物 / NMR / ナノ粒子 / 吸収性 / 非晶質 / 運動性 / cryo-TEM / 溶解性改善 / suspended-state NMR / 非晶質ナノ粒子 / AFM / ポリマー / 中分子薬物 / 界面 / 溶解 / SAXS / 相互作用 / 原子間力顕微鏡 / 小角X線散乱 / 溶解性 / 表面エネルギー / STEM-EDX / 湿式粉砕 / 分子間相互作用 / 固体NMR / 安定化 / 界面活性剤 / 固液界面 / 非晶質固体分散体 / Cryo-TEM / ナノ / 液中測定 / 原子間力顕微鏡（AFM / 透過型電子顕微鏡（TEM） / 構造評価 / 力学特性 / 原子間力顕微鏡（AFM） Less

NMR及び高速AFMによる分子レベルでの物性評価に基づく高活性な脂質ナノ粒子製剤開発Principal Investigator
- Principal Investigator
  
  植田圭祐
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
- Research Institution
  Chiba University
Elucidation of destabilization mechanism of drug amorphous nanosuspension for middle-molecule drug development
- Principal Investigator
  
  東顕二郎
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
- Research Institution
  Chiba University
Development of drug-rich phase-coexisting lipid nanoparticle formulations based on elucidation of molecular mechanism of liquid-liquid phase separation phenomenon of drugsPrincipal Investigator
- Principal Investigator
  
  植田圭祐
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
- Research Institution
  Chiba University
Structural evaluation of solid-liquid interface of drug nanoamorphous by suspended-state NMR
- Principal Investigator
  
  Higashi Kenjirou
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
- Research Institution
  Chiba University
Drug dissolution mechanism based on evaluation of polymer structure, mobility, and intermolecular interaction
- Principal Investigator
  
  Moribe Kunikazu
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
- Research Institution
  Chiba University
Development of drug-rich phase-forming solid dispersion formulations based on molecular-level characterization by NMRPrincipal Investigator
- Principal Investigator
  
  Ueda Keisuke
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
- Research Institution
  Chiba University
Design of drug amorphous nanosuspension to achieve a pharmaceutical formulation of poorly water-soluble drug
- Principal Investigator
  
  Higashi Kenjirou
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
- Research Institution
  Chiba University
Refined structural analysis and mechanical property of drug nano-formulation by AFM in aqueous meida
- Principal Investigator
  
  MORIBE KUNIKAZU
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Chiba University
Development of drug amorphous/nanocrystal hybrid formulation based on the molecular-level evaluation by solid-state NMRPrincipal Investigator
- Principal Investigator
  
  Ueda Keisuke
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Chiba University

All 2024 2023 2022 2021 2020 2019 2018 2017 2016

All Journal Article Presentation Book

[Book] ナノ・マイクロ微粒子の分散評価技術　核磁気共鳴（分担）2020
- Author(s)
  東　顕二郎、植田　圭祐、森部　久仁一　（分担）
- Total Pages
  227
- Publisher
  シーエムシー出版
- ISBN
  9784781314907
- Data Source
  KAKENHI-PROJECT-18K06592
[Book] 粉体の表面処理・複合化技術集大成2018
- Author(s)
  東顕二郎、植田圭祐、森部久仁一　分担執筆、内藤　牧男　監修
- Total Pages
  752
- Publisher
  テクノシステム
- ISBN
  9784924728813
- Data Source
  KAKENHI-PROJECT-18K06592
[Book] 最新の薬剤学知見と世界の開発状況をふまえた　前臨床／臨床医薬品開発の展望と戦略2018
- Author(s)
  植田圭祐他 (日本薬剤学会前臨床開発フォーカスグループ・経口吸収フォーカスグループ)
- Total Pages
  208
- Publisher
  じほう
- ISBN
  9784840750875
- Data Source
  KAKENHI-PROJECT-16K18859
[Book] 難水溶性薬物の経口製剤化技術最前線(固体分散体の過飽和溶解)2016
- Author(s)
  植田圭祐,森部久仁一
- Total Pages
  250
- Publisher
  シーエムシー出版
- Data Source
  KAKENHI-PROJECT-16K18859
[Journal Article] Mechanistic Analysis of Temperature-Dependent Curcumin Release from Poly(lactic-co-glycolic acid)/Poly(lactic acid) Polymer Nanoparticles2024
- Author(s)
  Sunazuka Yushi、Ueda Keisuke、Higashi Kenjirou、Wada Koichi、Moribe Kunikazu
- Journal Title
  
  Molecular Pharmaceutics
  
  Volume: 21 Issue: 3 Pages: 1424-1435
- DOI
  10.1021/acs.molpharmaceut.3c01066
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K06545
[Journal Article] Quantitative Investigation of Intestinal Drug Absorption Enhancement by Drug-Rich Nanodroplets Generated via Liquid?Liquid Phase Separation2024
- Author(s)
  Yoshikawa Etsushi、Ueda Keisuke、Hakata Rei、Higashi Kenjirou、Moribe Kunikazu
- Journal Title
  
  Molecular Pharmaceutics
  
  Volume: 21 Issue: 4 Pages: 1745-1755
- DOI
  10.1021/acs.molpharmaceut.3c01078
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K06545
[Journal Article] Crystallization of Amorphous Nifedipine Under Isothermal Conditions: Inter-laboratory Reproducibility and Investigation of the Factors Affecting Reproducibility2023
- Author(s)
  Miyazaki Tamaki、Mizoguchi Ryo、Ueda Keisuke、Shinozaki Taeko、Kamoto Mie、Takeda Yoshihiro、Sakuma Satoshi、Ito Naoya、Momo Michiko、Kawakami Kohsaku
- Journal Title
  
  Journal of Pharmaceutical Sciences
  
  Volume: 112 Issue: 10 Pages: 2703-2716
- DOI
  10.1016/j.xphs.2023.06.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K06545
[Journal Article] Understanding the rod-to-tube transformation of self-assembled ascorbyl dipalmitate lipid nanoparticles stabilized with PEGylated lipids2023
- Author(s)
  Chen Ziqiao、Higashi Kenjirou、Shigehisa Yuki、Ueda Keisuke、Yamamoto Keiji、Moribe Kunikazu
- Journal Title
  
  Nanoscale
  
  Volume: 15 Issue: 6 Pages: 2602-2613
- DOI
  10.1039/d2nr04987b
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K06545
[Journal Article] Vapor-Phase-Mediated Encapsulation of Guest Drug Molecules in the Hexagonal Columnar Form Structure of Polyethylene Glycol/γ-Cyclodextrin-Polypseudorotaxane2023
- Author(s)
  Kundu Sudeshna、Higashi Kenjirou、Takamizawa Makoto、Ueda Keisuke、Moribe Kunikazu
- Journal Title
  
  Crystal Growth & Design
  
  Volume: 23 Issue: 8 Pages: 6119-6129
- DOI
  10.1021/acs.cgd.3c00619
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K06545
[Journal Article] Modification of liposomes composed of a cationic lipid TMAG and an anionic lipid DSPG with a PEGylated lipid based on the investigation of lipid structures2023
- Author(s)
  Hohokabe Miyuki、Higashi Kenjirou、Yamada Yurina、Fujimoto Taiki、Tokumoto Taisei、Imamura Hiroshi、Morita Takeshi、Ueda Keisuke、Limwikrant Waree、Moribe Kunikazu
- Journal Title
  
  Colloids and Surfaces A: Physicochemical and Engineering Aspects
  
  Volume: 661 Pages: 130891-130891
- DOI
  10.1016/j.colsurfa.2022.130891
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06503, KAKENHI-PROJECT-22K06545, KAKENHI-PROJECT-23K23156
[Journal Article] Molecular-Level Structural Analysis of siRNA-Loaded Lipid Nanoparticles by <sup>1</sup>H NMR Relaxometry: Impact of Lipid Composition on Their Structural Properties2023
- Author(s)
  Ueda Keisuke、Sakagawa Yui、Saito Tomoki、Fujimoto Taiki、Nakamura Misaki、Sakuma Fumie、Kaneko Shun、Tokumoto Taisei、Nishimura Koki、Takeda Junpei、Arai Yuta、Yamamoto Katsuhiko、Ikeda Yukihiro、Higashi Kenjirou、Moribe Kunikazu
- Journal Title
  
  Molecular Pharmaceutics
  
  Volume: 20 Issue: 9 Pages: 4729-4742
- DOI
  10.1021/acs.molpharmaceut.3c00477
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K06545
[Journal Article] Preparation of a ternary amorphous solid dispersion using hot-melt extrusion for obtaining a stable colloidal dispersion of amorphous probucol nanoparticles2023
- Author(s)
  Hanada Naho、Higashi Kenjirou、Zhao Zhijing、Ueda Keisuke、Moribe Kunikazu
- Journal Title
  
  International Journal of Pharmaceutics
  
  Volume: 640 Pages: 122959-122959
- DOI
  10.1016/j.ijpharm.2023.122959
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K06545, KAKENHI-PROJECT-21K06509
[Journal Article] Ready-to-Use-Type Lyophilized Lipid Nanoparticle Formulation for the Postencapsulation of Messenger RNA2023
- Author(s)
  Tanaka Hiroki、Hagiwara Shinya、Shirane Daiki、Yamakawa Takuma、Sato Yuka、Matsumoto Chika、Ishizaki Kota、Hishinuma Miho、Chida Katsuyuki、Sasaki Kasumi、Yonemochi Etsuo、Ueda Keisuke、Higashi Kenjirou、Moribe Kunikazu、Tadokoro Takashi、Maenaka Katsumi、Taneichi Sakura、et al.
- Journal Title
  
  ACS Nano
  
  Volume: 17 Issue: 3 Pages: 2588-2601
- DOI
  10.1021/acsnano.2c10501
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K06545, KAKENHI-PROJECT-21K18320, KAKENHI-PROJECT-21K18035
[Journal Article] Quantitative Analysis of Drug Supersaturation Region by Temperature-Variable Nuclear Magnetic Resonance Measurements, Part 2: Effects of Solubilizer2023
- Author(s)
  Ueda Keisuke、Higashi Kenjirou、Moribe Kunikazu
- Journal Title
  
  Molecular Pharmaceutics
  
  Volume: 20 Issue: 4 Pages: 1872-1883
- DOI
  10.1021/acs.molpharmaceut.3c00050
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K06545
[Journal Article] 添加剤による難水溶性薬物の溶解性改善～基礎理論と最近の研究紹介～2023
- Author(s)
  東顕二郎、植田圭祐、森部久仁一
- Journal Title
  
  Pharm Tech Japan
  
  Volume: 39(4) Pages: 597-605
- Data Source
  KAKENHI-PROJECT-21K06509
[Journal Article] Quantitative Analysis of Drug Supersaturation Region by Temperature-Variable Nuclear Magnetic Resonance Measurements, Part 1: Effects of Polymer and Drug Chiralities2023
- Author(s)
  Ueda Keisuke、Higashi Kenjirou、Moribe Kunikazu
- Journal Title
  
  Molecular Pharmaceutics
  
  Volume: 20 Issue: 4 Pages: 1861-1871
- DOI
  10.1021/acs.molpharmaceut.2c00924
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K06545
[Journal Article] Supersaturation maintenance of carvedilol and chlorthalidone by cyclodextrin derivatives: Pronounced crystallization inhibition ability of methylated cyclodextrin2023
- Author(s)
  Liu Mengyao、Higashi Kenjirou、Ueda Keisuke、Moribe Kunikazu
- Journal Title
  
  International Journal of Pharmaceutics
  
  Volume: 637 Pages: 122876-122876
- DOI
  10.1016/j.ijpharm.2023.122876
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K06509, KAKENHI-PROJECT-22K06545
[Journal Article] NMR-Based Mechanistic Study of Crystal Nucleation Inhibition in a Supersaturated Drug Solution by Polyvinylpyrrolidone2022
- Author(s)
  Ueda Keisuke、Yamamoto Neo、Higashi Kenjirou、Moribe Kunikazu
- Journal Title
  
  Crystal Growth & Design
  
  Volume: 22 Issue: 5 Pages: 3235-3244
- DOI
  10.1021/acs.cgd.2c00084
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K06545
[Journal Article] Multistep Crystallization of Pharmaceutical Amorphous Nanoparticles via a Cognate Pathway of Oriented Attachment: Direct Evidence of Nonclassical Crystallization for Organic Molecules2022
- Author(s)
  Chen Ziqiao、Higashi Kenjirou、Ueda Keisuke、Moribe Kunikazu
- Journal Title
  
  Nano Letters
  
  Volume: 22 Issue: 16 Pages: 6841-6846
- DOI
  10.1021/acs.nanolett.2c01608
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K06509, KAKENHI-PROJECT-22K06545
[Journal Article] Enteric complex layer-coated controlled release of capsaicin from phytosterol/γ-cyclodextrin microparticles via guest exchange reaction with taurocholic acid2022
- Author(s)
  Sasako Hiroshi、Koyama Kazuo、Higashi Kenjirou、Ueda Keisuke、Ishimoto Arisa、Moribe Kunikazu
- Journal Title
  
  European Journal of Pharmaceutical Sciences
  
  Volume: 168 Pages: 106038-106038
- DOI
  10.1016/j.ejps.2021.106038
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16334
[Journal Article] Impact of Surfactants on the Performance of Clopidogrel-Copovidone Amorphous Solid Dispersions: Increased Drug Loading and Stabilization of Nanodroplets2022
- Author(s)
  Correa Soto Clara E.、Gao Yi、Indulkar Anura S.、Ueda Keisuke、Zhang Geoff G. Z.、Taylor Lynne S.
- Journal Title
  
  Pharmaceutical Research
  
  Volume: 39 Issue: 1 Pages: 167-188
- DOI
  10.1007/s11095-021-03159-w
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16334
[Journal Article] Computational approach to elucidate the formation and stabilization mechanism of amorphous formulation using molecular dynamics simulation and fragment molecular orbital calculation2022
- Author(s)
  Ma Xiaohan、Higashi Kenjirou、Fukuzawa Kaori、Ueda Keisuke、Kadota Kazunori、Tozuka Yuichi、Yonemochi Etsuo、Moribe Kunikazu
- Journal Title
  
  International Journal of Pharmaceutics
  
  Volume: 615 Pages: 121477-121477
- DOI
  10.1016/j.ijpharm.2022.121477
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K06509, KAKENHI-PROJECT-22K06545
[Journal Article] Preparation of redispersible dry nanoemulsion using chitosan-octenyl succinic anhydride starch polyelectrolyte complex as stabilizer2022
- Author(s)
  Sodalee Kun、Limwikrant Waree、Pongjanyakul Thaned、Ueda Keisuke、Higashi Kenjirou、Moribe Kunikazu、Puttipipatkhachorn Satit
- Journal Title
  
  Journal of Drug Delivery Science and Technology
  
  Volume: 73 Pages: 103433-103433
- DOI
  10.1016/j.jddst.2022.103433
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K06545
[Journal Article] Drug-Loaded Nanocarriers Composed of Cholesteryl Oleate Crystal Cores and Multiple-Nanosheet Shells of γ-Cyclodextrin Inclusion Complex Crystals2022
- Author(s)
  Ishimoto Arisa、Sasako Hiroshi、Omori Masaki、Higashi Kenjirou、Ueda Keisuke、Koyama Kazuo、Moribe Kunikazu
- Journal Title
  
  Langmuir
  
  Volume: 38 Issue: 34 Pages: 10454-10464
- DOI
  10.1021/acs.langmuir.2c01199
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K06545
[Journal Article] Unusual Correlation between the Apparent Amorphous Solubility of a Drug and Solubilizer Concentration Revealed by NMR Analysis2022
- Author(s)
  Ueda Keisuke、Higashi Kenjirou、Moribe Kunikazu
- Journal Title
  
  Molecular Pharmaceutics
  
  Volume: 19 Issue: 9 Pages: 3336-3349
- DOI
  10.1021/acs.molpharmaceut.2c00478
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K06545
[Journal Article] Effect of Polymer Species on Maximum Aqueous Phase Supersaturation Revealed by Quantitative Nuclear Magnetic Resonance Spectroscopy2021
- Author(s)
  Ueda Keisuke、Moseson Dana E.、Pathak Vaibhav、Taylor Lynne S.
- Journal Title
  
  Molecular Pharmaceutics
  
  Volume: 18 Issue: 3 Pages: 1344-1355
- DOI
  10.1021/acs.molpharmaceut.0c01174
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16334
[Journal Article] Effect of drug-coformer interactions on drug dissolution from a coamorphous in mesoporous silica2021
- Author(s)
  Budiman Arif、Higashi Kenjirou、Ueda Keisuke、Moribe Kunikazu
- Journal Title
  
  International Journal of Pharmaceutics
  
  Volume: 600 Pages: 120492-120492
- DOI
  10.1016/j.ijpharm.2021.120492
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16334
[Journal Article] Nanostructure and Molecular-Level Characterization of Aminoalkyl Methacrylate Copolymer and the Impact on Drug Solubilization Ability2021
- Author(s)
  Okamoto Yuta、Higashi Kenjirou、Morita Takeshi、Ueda Keisuke、Mukaide Sayaka、Takeda Junpei、Karashima Masatoshi、Ikeda Yukihiro、Moribe Kunikazu
- Journal Title
  
  Molecular Pharmaceutics
  
  Volume: 18 Issue: 11 Pages: 4111-4121
- DOI
  10.1021/acs.molpharmaceut.1c00526
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16334, KAKENHI-PROJECT-20K06985
[Journal Article] The nanostructure of rod-like ascorbyl dipalmitate nanoparticles stabilized by a small amount of DSPE-PEG2021
- Author(s)
  Chen Ziqiao、Higashi Kenjirou、Shidara Ryuhei、Ueda Keisuke、Morita Takeshi、Limwikrant Waree、Yamamoto Keiji、Moribe Kunikazu
- Journal Title
  
  International Journal of Pharmaceutics
  
  Volume: 602 Pages: 120599-120599
- DOI
  10.1016/j.ijpharm.2021.120599
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16334
[Journal Article] Formation mechanism of amorphous drug nanoparticles using the antisolvent precipitation method elucidated by varying the preparation temperature2021
- Author(s)
  Morikawa Chikako、Ueda Keisuke、Omori Masaki、Higashi Kenjirou、Moribe Kunikazu
- Journal Title
  
  International Journal of Pharmaceutics
  
  Volume: 610 Pages: 121210-121210
- DOI
  10.1016/j.ijpharm.2021.121210
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16334
[Journal Article] Salt Cocrystallization of Loxoprofen Sodium with Sugar: Reduction of the Propensity for Hydrate Formation by Forming a Continuous One-Dimensional Chain Structure of Sodium and Sugar2021
- Author(s)
  Fujito Takayuki、Oshima Tsumugi、Higashi Kenjirou、Ueda Keisuke、Ito Masataka、Masu Hyuma、Noguchi Shuji、Moribe Kunikazu
- Journal Title
  
  Crystal Growth & Design
  
  Volume: 22 Issue: 2 Pages: 1094-1103
- DOI
  10.1021/acs.cgd.1c01050
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16334
[Journal Article] Transition from Amorphous Cyclosporin A Nanoparticles to Size-Reduced Stable Nanocrystals in a Poloxamer 407 Solution2021
- Author(s)
  Chen Ziqiao、Higashi Kenjirou、Ueda Keisuke、Moribe Kunikazu
- Journal Title
  
  Molecular Pharmaceutics
  
  Volume: 19 Issue: 1 Pages: 188-199
- DOI
  10.1021/acs.molpharmaceut.1c00721
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16334, KAKENHI-PROJECT-21K06509
[Journal Article] Stabilization mechanism of amorphous carbamazepine by transglycosylated rutin, a non-polymeric amorphous additive with a high glass transition temperature2021
- Author(s)
  Aoki Chisa、Ma Xiaohan、Higashi Kenjirou、Ishizuka Yuya、Ueda Keisuke、Kadota Kazunori、Fukuzawa Kaori、Tozuka Yuichi、Kawakami Kohsaku、Yonemochi Etsuo、Moribe Kunikazu
- Journal Title
  
  International Journal of Pharmaceutics
  
  Volume: 600 Pages: 120491-120491
- DOI
  10.1016/j.ijpharm.2021.120491
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16334
[Journal Article] Variable-Temperature NMR Analysis of the Thermodynamics of Polymer Partitioning between Aqueous and Drug-Rich Phases and Its Significance for Amorphous Formulations2021
- Author(s)
  Ueda Keisuke、Higashi Kenjirou、Moribe Kunikazu、Taylor Lynne S.
- Journal Title
  
  Molecular Pharmaceutics
  
  Volume: 19 Issue: 1 Pages: 100-114
- DOI
  10.1021/acs.molpharmaceut.1c00664
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16334
[Journal Article] Partitioning of surfactant into drug-rich nanodroplets and its impact on drug thermodynamic activity and droplet size2021
- Author(s)
  Ueda Keisuke、Taylor Lynne S.
- Journal Title
  
  Journal of Controlled Release
  
  Volume: 330 Pages: 229-243
- DOI
  10.1016/j.jconrel.2020.12.018
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16334
[Journal Article] Amorphous Drug Solubility and Maximum Free Drug Concentrations in Cyclodextrin Solutions: A Quantitative Study Using NMR Diffusometry2021
- Author(s)
  Ueda Keisuke、Higashi Kenjirou、Moribe Kunikazu
- Journal Title
  
  Molecular Pharmaceutics
  
  Volume: 18 Issue: 7 Pages: 2764-2776
- DOI
  10.1021/acs.molpharmaceut.1c00311
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16334
[Journal Article] Revealing the mechanism of morphological variation of amorphous drug nanoparticles formed by aqueous dispersion of ternary solid dispersion2021
- Author(s)
  Zhao Zhijing、Higashi Kenjirou、Ueda Keisuke、Moribe Kunikazu
- Journal Title
  
  International Journal of Pharmaceutics
  
  Volume: 607 Pages: 120984-120984
- DOI
  10.1016/j.ijpharm.2021.120984
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16334, KAKENHI-PROJECT-21K06509
[Journal Article] Impact of Hypromellose Acetate Succinate Grade on Drug Amorphous Solubility and In Vitro Membrane Transport2020
- Author(s)
  Ueda Keisuke、Hate Siddhi S.、Taylor Lynne S.
- Journal Title
  
  Journal of Pharmaceutical Sciences
  
  Volume: 109 Issue: 8 Pages: 2464-2473
- DOI
  10.1016/j.xphs.2020.04.014
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16334
[Journal Article] Polymer Type Impacts Amorphous Solubility and Drug-Rich Phase Colloidal Stability: A Mechanistic Study Using Nuclear Magnetic Resonance Spectroscopy2020
- Author(s)
  Ueda Keisuke、Taylor Lynne S.
- Journal Title
  
  Molecular Pharmaceutics
  
  Volume: 17 Issue: 4 Pages: 1352-1362
- DOI
  10.1021/acs.molpharmaceut.0c00061
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16334
[Journal Article] Application of solid-state 13C relaxation time to prediction of the recrystallization inhibition strength of polymers on amorphous felodipine at low polymer loading2020
- Author(s)
  Ueda Keisuke、Okada Hitomi、Zhao Zhijing、Higashi Kenjirou、Moribe Kunikazu
- Journal Title
  
  International Journal of Pharmaceutics
  
  Volume: 581 Pages: 119300-119300
- DOI
  10.1016/j.ijpharm.2020.119300
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16334
[Journal Article] Correlation between drug dissolution and resistance to water-induced phase separation in solid dispersion formulations revealed by solid-state NMR spectroscopy2020
- Author(s)
  Okada Hitomi、Ueda Keisuke、Yasuda Yuki、Higashi Kenjirou、Inoue Motoki、Ito Masataka、Noguchi Shuji、Kawakami Kohsaku、Moribe Kunikazu
- Journal Title
  
  International Journal of Pharmaceutics
  
  Volume: 577 Pages: 119086-119086
- DOI
  10.1016/j.ijpharm.2020.119086
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16334
[Journal Article] Clarification of the Dissolution Mechanism of an Indomethacin/Saccharin/Polyvinylpyrrolidone Ternary Solid Dispersion by NMR Spectroscopy2020
- Author(s)
  Kosaka Mami、Higashi Kenjirou、Nishimura Misaki、Ueda Keisuke、Moribe Kunikazu
- Journal Title
  
  Journal of Pharmaceutical Sciences
  
  Volume: 109 Issue: 12 Pages: 3617-3624
- DOI
  10.1016/j.xphs.2020.09.009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K06985, KAKENHI-PROJECT-19K16334
[Journal Article] Enhanced Antipsoriatic Activity of Mycophenolic Acid Against the TNF-α-Induced HaCaT Cell Proliferation by Conjugated Poloxamer Micelles2020
- Author(s)
  Supasena Wiwat、Muangnoi Chawanphat、Thaweesest Wuttinont、Songkram Chalermkiat、Ueda Keisuke、Higashi Kenjirou、Moribe Kunikazu、Tanasupawat Somboon、Rojsitthisak Pornchai
- Journal Title
  
  Journal of Pharmaceutical Sciences
  
  Volume: 109 Issue: 2 Pages: 1153-1160
- DOI
  10.1016/j.xphs.2019.11.010
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16334
[Journal Article] Cryo-TEM and AFM Observation of the Time-Dependent Evolution of Amorphous Probucol Nanoparticles Formed by the Aqueous Dispersion of Ternary Solid Dispersions.2019
- Author(s)
  Zhao Z, Katai H, Higashi K, Ueda K, Kawakami K, Moribe K
- Journal Title
  
  Mol Pharm
  
  Volume: 印刷中 Issue: 5 Pages: 2184-2198
- DOI
  10.1021/acs.molpharmaceut.9b00158
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08190, KAKENHI-PROJECT-18K06592, KAKENHI-PROJECT-19K16334
[Journal Article] Molecular Mobility Suppression of Ibuprofen-Rich Amorphous Nanodroplets by HPMC Revealed by NMR Relaxometry and Its Significance with Respect to Crystallization Inhibition2019
- Author(s)
  Ueda Keisuke、Yamamoto Neo、Higashi Kenjirou、Moribe Kunikazu
- Journal Title
  
  Molecular Pharmaceutics
  
  Volume: 16 Issue: 12 Pages: 4968-4977
- DOI
  10.1021/acs.molpharmaceut.9b00840
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16334
[Journal Article] Biopredictive in vitro testing methods to assess intestinal drug absorption from supersaturating dosage forms2019
- Author(s)
  Hens Bart、Kataoka Makoto、Ueda Keisuke、Gao Ping、Tsume Yasuhiro、Augustijns Patrick、Kawakami Kohsaku、Yamashita Shinji
- Journal Title
  
  Journal of Drug Delivery Science and Technology
  
  Volume: － Pages: 101275-101275
- DOI
  10.1016/j.jddst.2019.101275
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16334
[Journal Article] Intermolecular Interactions between Drugs and Aminoalkyl Methacrylate Copolymer in Solution to Enhance the Concentration of Poorly Water-Soluble Drugs2019
- Author(s)
  Higashi Kenjirou、Ueda Keisuke、Moribe Kunikazu
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 67 Issue: 9 Pages: 906-914
- DOI
  10.1248/cpb.c18-00849
- NAID
  130007699649
- ISSN
  0009-2363, 1347-5223
- Year and Date
  2019-09-01
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16334
[Journal Article] Mechanistic elucidation of formation of drug-rich amorphous nanodroplets by dissolution of the solid dispersion formulation2019
- Author(s)
  Ueda Keisuke、Higashi Kenjirou、Moribe Kunikazu
- Journal Title
  
  International Journal of Pharmaceutics
  
  Volume: 561 Pages: 82-92
- DOI
  10.1016/j.ijpharm.2019.02.034
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K18859
[Journal Article] Effect of molecular weight of hypromellose on mucin diffusion and oral absorption behavior of fenofibrate nanocrystal2019
- Author(s)
  Ueda Keisuke、Iwai Takaaki、Sunazuka Yushi、Chen Ziqiao、Kato Nao、Higashi Kenjirou、Moribe Kunikazu
- Journal Title
  
  International Journal of Pharmaceutics
  
  Volume: 564 Pages: 39-47
- DOI
  10.1016/j.ijpharm.2019.04.033
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K18859, KAKENHI-PROJECT-19K16334
[Journal Article] Effect of Drug?Polymer Interactions through Hypromellose Acetate Succinate Substituents on the Physical Stability on Solid Dispersions Studied by Fourier-Transform Infrared and Solid-State Nuclear Magnetic Resonance2019
- Author(s)
  Ishizuka Yuya、Ueda Keisuke、Okada Hitomi、Takeda Junpei、Karashima Masatoshi、Yazawa Koji、Higashi Kenjirou、Kawakami Kohsaku、Ikeda Yukihiro、Moribe Kunikazu
- Journal Title
  
  Molecular Pharmaceutics
  
  Volume: 16 Issue: 6 Pages: 2785-2794
- DOI
  10.1021/acs.molpharmaceut.9b00301
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16334
[Journal Article] Molecular-level elucidation of saccharin-assisted rapid dissolution and high supersaturation level of drug from Eudragit E solid dispersion2018
- Author(s)
  Ueda Keisuke、Kanaya Harunobu、Higashi Kenjirou、Yamamoto Keiji、Moribe Kunikazu
- Journal Title
  
  Int. J. Pharm.
  
  Volume: 538 Issue: 1-2 Pages: 57-64
- DOI
  10.1016/j.ijpharm.2017.12.050
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K18859
[Journal Article] Mechanism of Enhanced Nifedipine Dissolution by Polymer-Blended Solid Dispersion through Molecular-Level Characterization2018
- Author(s)
  Ueda Keisuke、Yamazoe Chisato、Yasuda Yuki、Higashi Kenjirou、Kawakami Kohsaku、Moribe Kunikazu
- Journal Title
  
  Molecular Pharmaceutics
  
  Volume: 15 Issue: 9 Pages: 4099-4109
- DOI
  10.1021/acs.molpharmaceut.8b00523
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K18859
[Journal Article] Determination of Nonspherical Morphology of Doxorubicin-Loaded Liposomes by Atomic Force Microscopy.2018
- Author(s)
  Takahashi N, Higashi K, Ueda K, Yamamoto K, Moribe K.
- Journal Title
  
  J Pharm Sci.
  
  Volume: 107 Issue: 2 Pages: 717-726
- DOI
  10.1016/j.xphs.2017.10.009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08190
[Journal Article] Combined effects of the drug distribution and mucus diffusion properties of self-microemulsifying drug delivery systems on the oral absorption of fenofibrate2018
- Author(s)
  Sunazuka Yushi、Ueda Keisuke、Higashi Kenjirou、Tanaka Yusuke、Moribe Kunikazu
- Journal Title
  
  International Journal of Pharmaceutics
  
  Volume: 546 Issue: 1-2 Pages: 263-271
- DOI
  10.1016/j.ijpharm.2018.05.031
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K18859
[Journal Article] Morphological and physicochemical evaluation of two distinct glibenclamide/hypromellose amorphous nanoparticles prepared by the antisolvent method.2018
- Author(s)
  Yonashiro, H., Higashi, K., Morikawa, C., Ueda, K., Itoh, T., Ito, M., Masu, H., Noguchi, S., Moribe, K.
- Journal Title
  
  Molecular Pharamceutics
  
  Volume: 15（4） Issue: 4 Pages: 1587-1597
- DOI
  10.1021/acs.molpharmaceut.7b01122
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06592
[Journal Article] Synergetic Role of Hypromellose and Methacrylic Acid Copolymer in the Dissolution Improvement of Amorphous Solid Dispersions2017
- Author(s)
  Ohyagi N., Ueda K., Higashi K., Yamamoto K., Kawakami K., Moribe K.
- Journal Title
  
  J. Pharm. Sci.
  
  Volume: 106 Issue: 4 Pages: 1042-1050
- DOI
  10.1016/j.xphs.2016.12.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K18859
[Journal Article] Application of Solid-State NMR Relaxometry for Characterization and Formulation Optimization of Grinding-Induced Drug Nanoparticle2016
- Author(s)
  Ueda K., Higashi K., Moribe K.
- Journal Title
  
  Mol. Pharm.
  
  Volume: 13 Issue: 3 Pages: 852-862
- DOI
  10.1021/acs.molpharmaceut.5b00781
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K18859
[Presentation] 固体NMR緩和時間測定を用いた第二薬物混合によるfelodipine結晶化抑制メカニズムの解明2024
- Author(s)
  菅原日向, 植田圭祐, 東顕二郎, 森部久仁一
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-22K06545
[Presentation] リポソームへのdoxorubicin封入率にPEG修飾が及ぼす影響の評価2024
- Author(s)
  藤本泰輝, 植田圭祐, 東顕二郎, 森部久仁一
- Organizer
  PF研究会「物質・生命研究における小角散乱法の展開：現状と展望のための討論会」
- Data Source
  KAKENHI-PROJECT-22K06545
[Presentation] Ritonavirの非晶質溶解度に第2薬物が及ぼす影響の熱力学的解析2024
- Author(s)
  植田圭祐, 金子舜, 東顕二郎, 森部久仁一
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-22K06545
[Presentation] 脂質/γ-シクロデキストリン温度応答性ナノ粒子への薬物封入2024
- Author(s)
  関優太, 植田圭祐, 東顕二郎, 森部久仁一
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-22K06545
[Presentation] PEG修飾によるdoxorubicin封入リポソームの形態変化メカニズム評価2024
- Author(s)
  藤本泰輝, 植田圭祐, 東顕二郎, 森部久仁一
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-22K06545
[Presentation] 溶液1H NMR測定によるリポソーム界面へ修飾されたPEGの局在評価2024
- Author(s)
  東顕二郎, 仲村美咲, 植田圭祐, 森部久仁一
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-22K06545
[Presentation] 原子間力顕微鏡を用いたイリノテカン封入リポソームの力学的特性評価2024
- Author(s)
  喜田浩平, 植田圭祐, 東顕二郎, 森部久仁一
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-22K06545
[Presentation] 脂質ナノ粒子のpH依存的な構造変化にイオン化脂質が及ぼす影響2024
- Author(s)
  酒川優泉, 植田圭祐, 東顕二郎, 森部久仁一
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-22K06545
[Presentation] 分子運動性に基づく非晶質estradiolの物理的安定性予測2023
- Author(s)
  原脩祐、植田圭祐、東顕二郎、森部久仁一
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-22K06545
[Presentation] 溶液?H NMRによるナノエマルション中の薬物封入状態の定量的評価2023
- Author(s)
  富田紗枝子, 砂塚裕志, 植田圭祐, 東顕二郎, 森部久仁一
- Organizer
  第67回日本薬学会関東支部会
- Data Source
  KAKENHI-PROJECT-22K06545
[Presentation] NMR緩和時間測定によるritonavir結晶多形・非晶質の局所構造評価2023
- Author(s)
  鈴木雅人, 植田圭祐, 東顕二郎, 森部久仁一
- Organizer
  第67回日本薬学会関東支部会
- Data Source
  KAKENHI-PROJECT-22K06545
[Presentation] NMRを用いた脂質ナノ粒子への核酸封入機構の解明2023
- Author(s)
  植田圭祐, 西村公樹, 武田　純平, 新井　勇太, 山本　克彦, 池田幸弘, 東顕二郎, 森部久仁一
- Organizer
  第39回日本DDS学会
- Data Source
  KAKENHI-PROJECT-22K06545
[Presentation] Correlation between drug molecular state in cyclodextrin-polypseudorotaxane complexes and its sublimation rate2023
- Author(s)
  Kundu, S., Ueda, K., Higashi, K., Moribe, K.
- Organizer
  International Conference on Science and Technology of Pharmaceutical Glass
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K06545
[Presentation] Acetaminophen封入poloxamer 407ミセルの結晶構造とゲル物性の関連性評価2023
- Author(s)
  佐久間文絵, 植田圭祐, 東顕二郎, 庵原大輔, 平山文敏, 森部久仁一
- Organizer
  日本薬剤学会　第48回製剤・創剤セミナー
- Data Source
  KAKENHI-PROJECT-22K06545
[Presentation] In situ X線散乱測定を用いた冷却過程におけるドキソルビシン封入リポソームの形態及び分子状態評価2023
- Author(s)
  徳本大成、植田圭祐、東顕二郎、小坂井賢太、田口宗孝、大坂恵一、岩尾康範、森部久仁一
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-22K06545
[Presentation] 薬物の過飽和溶解領域の定量的理解2023
- Author(s)
  植田圭祐
- Organizer
  経口剤のBEに関する検討会（BE検討会）特別講演会
- Invited
- Data Source
  KAKENHI-PROJECT-22K06545
[Presentation] Acetaminophen封入がpoloxamer 407のミセル及びゲル特性に及ぼす影響2023
- Author(s)
  佐久間文絵, 植田圭祐, 東顕二郎, 庵原大輔, 平山文敏, 森部久仁一
- Organizer
  新製剤技術とエンジニアリングを考える会　第20回技術講演会
- Data Source
  KAKENHI-PROJECT-22K06545
[Presentation] Poloxamer 407のミセル及びゲル特性にacetaminophen封入が及ぼす影響2023
- Author(s)
  佐久間文絵, 植田圭祐, 東顕二郎, 庵原大輔, 平山文敏, 森部久仁一
- Organizer
  日本薬剤学会第38年会
- Data Source
  KAKENHI-PROJECT-22K06545
[Presentation] ナノ製剤の品質評価基盤を支える粒子径評価技術2023
- Author(s)
  植田圭祐
- Organizer
  第67回日本薬学会関東支部会　ランチョンセミナー
- Invited
- Data Source
  KAKENHI-PROJECT-22K06545
[Presentation] 分子動力学計算を用いた Eudragit? Eによる薬物可溶化機構の解明2023
- Author(s)
  齊藤智輝, 植田圭祐, 東顕二郎, 奥脇弘次, 古石誉之, 福澤薫, 米持悦生, 森部久仁一
- Organizer
  第67回日本薬学会関東支部会
- Data Source
  KAKENHI-PROJECT-22K06545
[Presentation] Effect of formulation component on supersaturation and phase separation of poorly water-soluble drugs2023
- Author(s)
  Kunikazu Moribe、Keisuke Ueda、Kenjirou Higashi
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-22K06545
[Presentation] Formation and stabilization mechanism of colloidal dispersions of drug nanoparticles obtained from ternary solid dispersions2023
- Author(s)
  Higashi, K., Ueda, K., Moribe, K.,
- Organizer
  Asisan Federation for Pharmaceutical Sciences 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06509
[Presentation] Solid-state NMR relaxometry for characterizing amorphous drug formulations2023
- Author(s)
  Ueda, K.
- Organizer
  9th International Discussion Meeting on Relaxations in Complex Systems (9 IDMRCS)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K06545
[Presentation] 過飽和製剤による難溶性薬物の経口吸収改善メカニズム2023
- Author(s)
  植田圭祐
- Organizer
  第67回日本薬学会関東支部会　若手シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-22K06545
[Presentation] PEG修飾がdoxorubicin封入リポソームの薬物封入効率及び形態変化に及ぼす影響2023
- Author(s)
  藤本泰輝, 植田圭祐, 東顕二郎, 森部久仁一
- Organizer
  第67回日本薬学会関東支部会
- Data Source
  KAKENHI-PROJECT-22K06545
[Presentation] Elucidation of the mechanism of morphological change in DOX-loaded liposome by cryo-TEM and X-ray scattering2023
- Author(s)
  Tokumoto Taisei、Ueda Keisuke、Higashi Kenjirou、Moribe Kunikazu
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-22K06545
[Presentation] Formation and stabilization mechanism of colloidal dispersions of drug nanoparticles obtained from ternary solid dispersions2023
- Author(s)
  Higashi, K., Ueda, K., Moribe, K.,
- Organizer
  Asisan Federation for Pharmaceutical Sciences 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K06545
[Presentation] 溶液1H NMR測定を用いたリポソーム界面へ修飾したPEGの分子状態評価2023
- Author(s)
  仲村美咲, 植田圭祐, 東顕二郎, 森部久仁一
- Organizer
  日本薬剤学会第38年会
- Data Source
  KAKENHI-PROJECT-22K06545
[Presentation] 異なる薬物の共存がritonavirの液-液相分離及び非晶質溶解度に与える影響の評価2023
- Author(s)
  金子舜, 植田圭祐, 東顕二郎, 森部久仁一
- Organizer
  第40回製剤と粒子設計シンポジウム
- Data Source
  KAKENHI-PROJECT-22K06545
[Presentation] 難溶性薬物の経口製剤開発における薬物の液-液相分離現象の重要性2023
- Author(s)
  植田圭祐
- Organizer
  コロイド先端技術講座2022　ソフトマターの「液液」相分離
- Invited
- Data Source
  KAKENHI-PROJECT-22K06545
[Presentation] Effect of PEG modification on drug encapsulation efficiency and morphology of doxorubicin-loaded liposome2023
- Author(s)
  Fujimoto, K., Ueda, K., Higashi, K., Moribe, K.
- Organizer
  Asisan Federation for Pharmaceutical Sciences 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K06545
[Presentation] NMR-based characterization of liquid-liquid phase separation of supersaturated drug2023
- Author(s)
  Ueda, K.
- Organizer
  International Conference on Science and Technology of Pharmaceutical Glass
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K06545
[Presentation] 溶液NMRによる薬物過飽和溶解領域の定量的解析2023
- Author(s)
  植田圭祐, 東顕二郎, 森部久仁一
- Organizer
  第40回製剤と粒子設計シンポジウム
- Data Source
  KAKENHI-PROJECT-22K06545
[Presentation] 液-液相分離により形成されるcilnidipine濃縮相物性が腸管吸収性に及ぼす影響2022
- Author(s)
  竹本士竜, 植田圭祐, 東顕二郎, 森部久仁一
- Organizer
  日本薬剤学会第37年会
- Data Source
  KAKENHI-PROJECT-22K06545
[Presentation] 調製時に用いる溶媒が非晶質cyclosporine Aの分子状態に及ぼす影響2022
- Author(s)
  内田みず穂, 植田圭祐, 東顕二郎, 森部久仁一
- Organizer
  日本薬剤学会　第47回製剤・創剤セミナー
- Data Source
  KAKENHI-PROJECT-22K06545
[Presentation] Characterization of drug-rich phase formed by liquid-liquid phase separation and its significance on intestinal absorption of drug.2022
- Author(s)
  Takemoto, S., Ueda, K., Higashi, K., Moribe, K.
- Organizer
  4th?International Symposium on BA/BE of Oral Drug Products, 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K06545
[Presentation] Acetaminophen封入がpoloxamer 407のゲル形成に及ぼす影響の評価2022
- Author(s)
  佐久間文絵, 植田圭祐, 東顕二郎, 森部久仁一
- Organizer
  第66回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-22K06545
[Presentation] 薬物/シクロデキストリン‐ポリシュードロタキサン複合体の分子運動性が薬物昇華速度に与える影響2022
- Author(s)
  Sudeshna Kundu, 植田圭祐, 東顕二郎, 森部久仁一
- Organizer
  第38回シクロデキストリンシンポジウム
- Data Source
  KAKENHI-PROJECT-22K06545
[Presentation] Importance of evaluating drug amorphous solubility in the development of supersaturated formulations2022
- Author(s)
  Ueda, K.
- Organizer
  4th?International Symposium on BA/BE of Oral Drug Products, 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K06545
[Presentation] シクロデキストリン誘導体によるchlorthalidone結晶化抑制作用の評価2022
- Author(s)
  劉夢遥，植田圭祐, 東顕二郎, 森部久仁一
- Organizer
  日本薬剤学会第37年会
- Data Source
  KAKENHI-PROJECT-22K06545
[Presentation] 調製時に用いる溶媒が非晶質cyclosporine Aの分子状態に及ぼす影響2022
- Author(s)
  内田みず穂, 植田圭祐, 東顕二郎, 森部久仁一
- Organizer
  日本薬剤学会　第47回製剤・創剤セミナー
- Data Source
  KAKENHI-PROJECT-21K06509
[Presentation] NMRを利用した薬物過飽和溶解減少の分子機構解明2022
- Author(s)
  植田圭祐
- Organizer
  日本薬剤学会第37年会
- Invited
- Data Source
  KAKENHI-PROJECT-22K06545
[Presentation] エマルション中における過飽和溶解fenofibrateの相分離挙動評価2022
- Author(s)
  江寺理紗, 植田圭祐, 東顕二郎, 森部久仁一
- Organizer
  日本薬剤学会第37年会
- Data Source
  KAKENHI-PROJECT-22K06545
[Presentation] エマルション製剤における過飽和溶解fenofibrateの相分離挙動評価2022
- Author(s)
  江寺理紗, 植田圭祐, 東顕二郎, 森部久仁一
- Organizer
  日本薬剤学会　第48回製剤・創剤セミナー
- Data Source
  KAKENHI-PROJECT-22K06545
[Presentation] 溶液1H NMR測定によるリポソーム界面へ修飾したPEG鎖の評価2022
- Author(s)
  仲村美咲, 植田圭祐, 東顕二郎, 森部久仁一
- Organizer
  第66回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-22K06545
[Presentation] Eudragit E POの構造がfelodipineの結晶化抑制作用に及ぼす影響2022
- Author(s)
  向出彩華, 植田圭祐, 東顕二郎, 森部久仁一
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-20K06985
[Presentation] Cyclosporine A非晶質の分子状態に調製条件が及ぼす影響2022
- Author(s)
  内田みず穂, 植田圭祐, 東顕二郎, 森部久仁一
- Organizer
  日本薬剤学会第37年会
- Data Source
  KAKENHI-PROJECT-22K06545
[Presentation] Cryo-TEM及びSAXSを用いたドキソルビシン封入リポソームの形態変化メカニズム評価2022
- Author(s)
  徳本大成, 植田圭祐, 東顕二郎, 森部久仁一
- Organizer
  日本薬剤学会第37年会
- Data Source
  KAKENHI-PROJECT-22K06545
[Presentation] 過飽和溶液中にて形成されるcilnidipine濃縮相の粒子特性が腸管吸収性に及ぼす影響2022
- Author(s)
  竹本士竜, 植田圭祐, 東顕二郎, 森部久仁一
- Organizer
  第39回製剤と粒子設計シンポジウム
- Data Source
  KAKENHI-PROJECT-22K06545
[Presentation] シクロデキストリン誘導体によるクロロタリドン結晶化抑制作用の評価2022
- Author(s)
  劉夢遥，植田圭祐, 東顕二郎, 森部久仁一
- Organizer
  第38回シクロデキストリンシンポジウム
- Data Source
  KAKENHI-PROJECT-22K06545
[Presentation] 高温固体1H NMR分光法による薬物/polymer間相互作用の評価2022
- Author(s)
  金子舜, 植田圭祐, 東顕二郎, 森部久仁一
- Organizer
  第66回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-22K06545
[Presentation] In situ X線散乱測定を用いたドキソルビシン封入リポソーム形態変化機構の解明2022
- Author(s)
  徳本大成, 植田圭祐, 東顕二郎, 森部久仁一
- Organizer
  第39回製剤と粒子設計シンポジウム
- Data Source
  KAKENHI-PROJECT-22K06545
[Presentation] Cyclosporine A非晶質の分子状態に調製条件が及ぼす影響2022
- Author(s)
  内田みず穂, 植田圭祐, 東顕二郎, 森部久仁一
- Organizer
  日本薬剤学会第37年会
- Data Source
  KAKENHI-PROJECT-21K06509
[Presentation] Impact of molecular state of drug/cyclodextrin-polypseudorotaxane complexes on drug sublimation rate2022
- Author(s)
  Sudeshna Kundu, 植田圭祐, 東顕二郎, 森部久仁一
- Organizer
  日本薬剤学会第37年会
- Data Source
  KAKENHI-PROJECT-22K06545
[Presentation] 過飽和溶液中にて形成されるcilnidipine濃縮相物性が腸管吸収性に及ぼす影響2022
- Author(s)
  竹本士竜, 植田圭祐, 東顕二郎, 森部久仁一
- Organizer
  新製剤技術とエンジニアリングを考える会　第19回技術講演会
- Data Source
  KAKENHI-PROJECT-22K06545
[Presentation] エンタルピー緩和時間測定によるエストラジオール固体分散体の分子運動性評価2021
- Author(s)
  原脩祐, 植田圭祐, 東顕二郎, 森部久仁一
- Organizer
  第65回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-19K16334
[Presentation] Effect of ritonavir-saccharin interaction of coamorphous in mesoporous silica on its dissolution property2021
- Author(s)
  Arif Budiman, Keisuke Ueda, Kenjirou Higashi, Kunikazu Moribe
- Organizer
  日本薬剤学会第36年会
- Data Source
  KAKENHI-PROJECT-19K16334
[Presentation] 薬物-richナノドロップレット形成による薬物の消化管吸収性改善メカニズムの解明2021
- Author(s)
  吉川悦司, 植田圭祐, 東顕二郎, 森部久仁一
- Organizer
  第9回PhysChem Forum Japan
- Data Source
  KAKENHI-PROJECT-19K16334
[Presentation] Evaluation of inhibitory effect of cyclodextrin derivatives on carvedilol crystallization2021
- Author(s)
  劉夢遥，植田圭祐, 東顕二郎, 森部久仁一
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-19K16334
[Presentation] Eudragit E POの液中構造が薬物の結晶成長抑制作用に及ぼす影響2021
- Author(s)
  向出彩華，植田圭祐, 東顕二郎, 森部久仁一
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-20K06985
[Presentation] 糖類とNa+からなる一次元連鎖構造形成によるロキソプロフェンナトリウムの吸湿性改善2021
- Author(s)
  大嶋紬, 藤戸貴之, 植田圭祐, 東顕二郎, 桝飛雄真, 森部久仁一
- Organizer
  令和3年（2021年）度日本結晶学会年会
- Data Source
  KAKENHI-PROJECT-19K16334
[Presentation] 内水相組成が異なるイリノテカン封入リポソームの比較検討2021
- Author(s)
  飛鷹凌, 植田圭祐, 東顕二郎, 森部久仁一
- Organizer
  日本薬剤学会第36年会
- Data Source
  KAKENHI-PROJECT-19K16334
[Presentation] Eudragit E POの液中構造が薬物の結晶成長抑制作用に及ぼす影響2021
- Author(s)
  向出彩華，植田圭祐, 東顕二郎, 森部久仁一
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-19K16334
[Presentation] リポソームに封入されたイリノテカン硫酸塩及びスクロース8硫酸塩の比較2021
- Author(s)
  飛鷹凌, 植田圭祐, 東顕二郎, 森部久仁一
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-19K16334
[Presentation] カルバマゼピンを封入した脂質/シクロデキストリン温度応答性ナノ粒子の構造評価2021
- Author(s)
  大森将貴, 植田圭祐, 東顕二郎, 笹子浩史, 森部久仁一
- Organizer
  第9回PhysChem Forum Japan
- Data Source
  KAKENHI-PROJECT-19K16334
[Presentation] カルバマゼピンを封入した脂質/γ-シクロデキストリン温度応答性ナノ粒子の構造評価2021
- Author(s)
  大森将貴, 植田圭祐, 東顕二郎, 笹子浩史, 森部久仁一
- Organizer
  日本薬剤学会第36年会
- Data Source
  KAKENHI-PROJECT-19K16334
[Presentation] カルバマゼピンを封入した温度応答性ナノ粒子の構造評価2021
- Author(s)
  大森将貴, 植田圭祐, 東顕二郎, 笹子浩史, 森部久仁一
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-19K16334
[Presentation] 内水相組成が異なるイリノテカン封入リポソームの薬物分子状態評価2021
- Author(s)
  飛鷹凌, 植田圭祐, 東顕二郎, 森部久仁一
- Organizer
  第37回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-19K16334
[Presentation] 異なる内水相組成で調製したイリノテカン封入リポソームの物性評価2021
- Author(s)
  飛鷹凌, 植田圭祐, 東顕二郎, 森部久仁一
- Organizer
  分子製剤学合同セミナー
- Data Source
  KAKENHI-PROJECT-19K16334
[Presentation] 固体分散体の溶出により形成される薬物-richドロップレットが薬物の消化管吸収性に及ぼす影響2021
- Author(s)
  吉川悦司, 植田圭祐, 東顕二郎, 森部久仁一
- Organizer
  第38回製剤と粒子設計シンポジウム
- Data Source
  KAKENHI-PROJECT-19K16334
[Presentation] 糖類とロキソプロフェンナトリウム塩共結晶の結晶構造が吸湿性に与える影響2021
- Author(s)
  大嶋紬, 藤戸貴之, 植田圭祐, 東顕二郎, 桝飛雄真, 森部久仁一
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-19K16334
[Presentation] シクロデキストリ誘導体による薬物結晶化抑制作用の評価2021
- Author(s)
  劉夢遥，植田圭祐, 東顕二郎, 森部久仁一
- Organizer
  第37回シクロデキストリンシンポジウム
- Data Source
  KAKENHI-PROJECT-19K16334
[Presentation] 非晶質シクロスポリンAの構造に調製条件が及ぼす影響2021
- Author(s)
  内田みず穂, 植田圭祐, 東顕二郎, 森部久仁一
- Organizer
  第65回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-19K16334
[Presentation] Cholesterol添加がdoxorubicin封入リポソームの形態に及ぼす影響2021
- Author(s)
  徳本大成, 植田圭祐, 東顕二郎, 森部久仁一
- Organizer
  第65回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-19K16334
[Presentation] 薬物-richドロップレットの物理的安定性及び腸管吸収性に及ぼす界面活性剤の影響2021
- Author(s)
  吉川悦司, 植田圭祐, 東顕二郎, 森部久仁一
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-19K16334
[Presentation] エマルション中における過飽和溶解薬物の相分離挙動評価2021
- Author(s)
  江寺理紗, 植田圭祐, 東顕二郎, 森部久仁一
- Organizer
  日本薬剤学会第36年会
- Data Source
  KAKENHI-PROJECT-19K16334
[Presentation] Eudragit E POの液中構造がフェロジピンの結晶化抑制作用に及ぼす影響2021
- Author(s)
  向出彩華, 植田圭祐, 東顕二郎, 森部久仁一
- Organizer
  第38回製剤と粒子設計シンポジウム
- Data Source
  KAKENHI-PROJECT-19K16334
[Presentation] Eudragit E POの液中構造がfelodipineの結晶成長抑制作用に及ぼす影響2021
- Author(s)
  向出彩華, 植田圭祐, 東顕二郎, 森部久仁一
- Organizer
  分子製剤学合同セミナー
- Data Source
  KAKENHI-PROJECT-19K16334
[Presentation] Eudragit Eの液中構造がフェロジピンの結晶成長抑制作用に及ぼす影響2021
- Author(s)
  向出彩華, 植田圭祐, 東顕二郎, 森部久仁一
- Organizer
  日本薬剤学会第36年会
- Data Source
  KAKENHI-PROJECT-20K06985
[Presentation] 高分子添加剤が薬物非晶質溶解度に及ぼす影響 : NMRを用いた定量的解析2021
- Author(s)
  植田圭祐, 東顕二郎, Lynne S. Taylor, 森部久仁一
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-19K16334
[Presentation] Eudragit E POの液中構造がフェロジピンの結晶化抑制作用に及ぼす影響2021
- Author(s)
  向出彩華, 植田圭祐, 東顕二郎, 森部久仁一
- Organizer
  第38回製剤と粒子設計シンポジウム
- Data Source
  KAKENHI-PROJECT-20K06985
[Presentation] 薬物-richドロップレットの物理的安定性及び消化管吸収性に及ぼす界面活性剤の影響2021
- Author(s)
  吉川悦司, 植田圭祐, 東顕二郎, 森部久仁一
- Organizer
  日本薬剤学会第36年会
- Data Source
  KAKENHI-PROJECT-19K16334
[Presentation] Eudragit Eの液中構造がフェロジピンの結晶成長抑制作用に及ぼす影響2021
- Author(s)
  向出彩華, 植田圭祐, 東顕二郎, 森部久仁一
- Organizer
  日本薬剤学会第36年会
- Data Source
  KAKENHI-PROJECT-19K16334
[Presentation] オレイン酸コレステリル/γ-シクロデキストリンナノ粒子の温度応答性構造変化の評価2021
- Author(s)
  大森将貴, 植田圭祐, 東顕二郎, 笹子浩史, 神山和夫, 森部久仁一
- Organizer
  第37回シクロデキストリンシンポジウム
- Data Source
  KAKENHI-PROJECT-19K16334
[Presentation] 薬物を封入した脂質/γ-シクロデキストリン温度応答性ナノ粒子の構造評価2021
- Author(s)
  大森将貴, 植田圭祐, 東顕二郎, 笹子浩史, 森部久仁一
- Organizer
  第37回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-19K16334
[Presentation] 非晶質固体分散体水分散時の薬物相分離挙動が腸管吸収性に及ぼす影響2021
- Author(s)
  竹本士竜, 植田圭祐, 東顕二郎, 森部久仁一
- Organizer
  第65回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-19K16334
[Presentation] 糖類との塩共結晶化によるロキソプロフェンナトリウムの吸湿性改善機構解明2021
- Author(s)
  大嶋紬, 藤戸貴之, 植田圭祐, 東顕二郎, 桝飛雄真, 森部久仁一
- Organizer
  日本薬剤学会第36年会
- Data Source
  KAKENHI-PROJECT-19K16334
[Presentation] 固体NMR測定による固体分散体の溶出性及び水接触時の相分離の関係性評価2020
- Author(s)
  岡田ひとみ, 植田圭祐, 東顕二郎 , 森部久仁一
- Organizer
  日本薬剤学会第35年会
- Data Source
  KAKENHI-PROJECT-19K16334
[Presentation] 溶液NMR測定を用いたPVPによる薬物結晶核生成抑制メカニズムの評価2020
- Author(s)
  山本　根生、植田　圭祐、東　顕二郎、森部　久仁一
- Organizer
  日本薬剤学会第35年会
- Data Source
  KAKENHI-PROJECT-20K06985
[Presentation] Eudragit E POの液中構造が薬物の結晶化抑制作用に及ぼす影響2020
- Author(s)
  向出彩華, 植田圭祐, 東顕二郎, 森部久仁一
- Organizer
  第64回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-20K06985
[Presentation] 脂質分解時におけるSEDDS製剤の形態変化メカニズム2020
- Author(s)
  加藤菜穂, 植田圭祐, 東顕二郎 , 森部久仁一
- Organizer
  日本薬剤学会第35年会
- Data Source
  KAKENHI-PROJECT-19K16334
[Presentation] Irinotecan封入リポソームの調製及び薬物封入状態の評価2020
- Author(s)
  飛鷹凌, 植田圭祐, 東顕二郎, 森部久仁一
- Organizer
  第64回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-19K16334
[Presentation] 調製条件がglibenclamide非晶質ナノ粒子の物理的安定性に及ぼす影響2020
- Author(s)
  東顕二郎、森川　千佳子、植田圭祐、森部久仁一
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-18K06592
[Presentation] 薬物-richナノドロップレットの物理的安定性に及ぼす界面活性剤の影響2020
- Author(s)
  吉川悦司, 植田圭祐, 東顕二郎, 森部久仁一
- Organizer
  第64回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-19K16334
[Presentation] 糖類との塩共結晶調製によるロキソプロフェンナトリウムの吸湿性改善2020
- Author(s)
  大嶋紬, 藤戸貴之, 植田圭祐, 東顕二郎, 桝飛雄真, 森部久仁一
- Organizer
  第64回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-19K16334
[Presentation] 固体分散体組成が水分散時のprobucol非晶質ナノ粒子のサイズに及ぼす影響2020
- Author(s)
  趙　芝菁、植田圭祐, 東顕二郎 , 森部久仁一
- Organizer
  日本薬剤学会第35年会
- Data Source
  KAKENHI-PROJECT-19K16334
[Presentation] Characterization of ritonavir-saccharin coamorphous incorporated in mesoporous silica2020
- Author(s)
  Arif Budiman, Keisuke Ueda, Kenjirou Higashi, Kunikazu Moribe
- Organizer
  第64回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-19K16334
[Presentation] Stabilization mechanism of amorphous solid dispersion of carbamazepine/α-glucosyl rutin elucidated by computational chemistry2020
- Author(s)
  馬梟寒、植田圭祐、東顕二郎、福澤薫、米持悦生、森部久仁一
- Organizer
  日本薬剤学会第35年会
- Data Source
  KAKENHI-PROJECT-19K16334
[Presentation] Eudragit E POの液中構造が薬物の結晶化抑制作用に及ぼす影響2020
- Author(s)
  向出彩華, 植田圭祐, 東顕二郎, 森部久仁一
- Organizer
  第64回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-19K16334
[Presentation] 溶液NMR測定を用いたPVPによる薬物結晶核生成抑制メカニズムの評価2020
- Author(s)
  山本　根生、植田　圭祐、東　顕二郎、森部　久仁一
- Organizer
  日本薬剤学会第35年会
- Data Source
  KAKENHI-PROJECT-19K16334
[Presentation] カルバマゼピン封入オレイン酸コレステリル/g-シクロデキストリンナノ粒子の構造評価2020
- Author(s)
  大森将貴, 植田圭祐, 東顕二郎, 笹子浩史, 森部久仁一
- Organizer
  第64回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-19K16334
[Presentation] Polyvinylpyrrolidone によるchlorthalidone 過飽和溶液安定化メカニズムの解明2019
- Author(s)
  山本　根生, 植田圭祐, 東顕二郎 , 森部久仁一
- Organizer
  第25回創剤フォーラム若手研究会
- Data Source
  KAKENHI-PROJECT-19K16334
[Presentation] 脂質分解が自己乳化型エマルション製剤の形態に及ぼす影響2019
- Author(s)
  加藤　菜穂, 植田圭祐, 東顕二郎 , 森部久仁一
- Organizer
  第25回創剤フォーラム若手研究会
- Data Source
  KAKENHI-PROJECT-19K16334
[Presentation] 固体分散体の水接触時の分子状態変化がnifedipine溶出性に及ぼす影響2019
- Author(s)
  岡田ひとみ, 植田圭祐, 東顕二郎 , 森部久仁一
- Organizer
  第44回製剤・創剤セミナー
- Data Source
  KAKENHI-PROJECT-19K16334
[Presentation] 過飽和溶液におけるChlorthalidone結晶核生成抑制メカニズムの解明2019
- Author(s)
  山本　根生, 植田圭祐, 東顕二郎 , 森部久仁一
- Organizer
  第63回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-19K16334
[Presentation] フラボノイド配糖体による過飽和溶液からの薬物結晶核生成抑制メカニズムの解明2019
- Author(s)
  髙橋寿実, 植田圭祐, 東顕二郎, 森部久仁一
- Organizer
  第44回製剤・創剤セミナー
- Data Source
  KAKENHI-PROJECT-19K16334
[Presentation] Preparation of amorphous nanoparticles for drugs with mid-molecular weight by wet bead milling and its characterization2019
- Author(s)
  Chen, Z., Ueda, K., Higashi, K., Moribe, K.
- Organizer
  The 3rd Workshop for Japan-Korea Young Scientists on Pharmaceutics
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06592
[Presentation] 3成分固体分散体の組成が水に分散時のprobucol非晶質ナノ粒子のサイズに及ぼす影響2019
- Author(s)
  趙芝菁,植田圭祐, 東顕二郎, 森部久仁一
- Organizer
  第36回製剤と粒子設計シンポジウム
- Data Source
  KAKENHI-PROJECT-19K16334
[Presentation] Glibenclamide 非晶質ナノ粒子の安定性に及ぼす調製条件の影響2019
- Author(s)
  森川千佳子, 植田圭祐, 東顕二郎 , 森部久仁一
- Organizer
  日本薬剤学会34年会
- Data Source
  KAKENHI-PROJECT-19K16334
[Presentation] Quercetin配糖体による薬物濃縮相の安定化メカニズム解明2019
- Author(s)
  髙橋寿実, 植田圭祐, 東顕二郎, 森部久仁一
- Organizer
  第139年会日本薬学会
- Data Source
  KAKENHI-PROJECT-16K18859
[Presentation] 水接触時の相分離が固体分散体からのnifedipine溶出性に及ぼす影響2019
- Author(s)
  岡田ひとみ, 植田圭祐, 東顕二郎 , 森部久仁一
- Organizer
  第25回創剤フォーラム若手研究会
- Data Source
  KAKENHI-PROJECT-19K16334
[Presentation] 固体分散体の水接触時の分子状態変化がnifedipine溶出性に及ぼす影響2019
- Author(s)
  岡田ひとみ, 植田圭祐, 東顕二郎 , 森部久仁一
- Organizer
  新製剤技術とエンジニアリングを考える会第１７回講演会
- Data Source
  KAKENHI-PROJECT-19K16334
[Presentation] Elucidation of intermolecular interactions between carbamazepine and α-glycosyl rutin in amorphous solid dispersion by fragment molecular orbital calculation2019
- Author(s)
  Xiaohan Ma, Keisuke Ueda, Kenjirou Higashi, Kaori Fukuzawa, Etsuo Yonemochi, Kunikazu Moribe
- Organizer
  製剤機械技術学会第29回大会
- Data Source
  KAKENHI-PROJECT-19K16334
[Presentation] NMR測定を用いたフラボノイド配糖体による薬物結晶核生成抑制メカニズムの解明2019
- Author(s)
  髙橋寿実, 植田圭祐, 東顕二郎, 森部久仁一
- Organizer
  第25回創剤フォーラム若手研究会
- Data Source
  KAKENHI-PROJECT-19K16334
[Presentation] SEDDS製剤における脂質分解がエマルションの形態変化に及ぼす影響2019
- Author(s)
  加藤　菜穂, 植田圭祐, 東顕二郎 , 森部久仁一
- Organizer
  第63回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-19K16334
[Presentation] Effect of lipolysis on emulsion droplet morphology formed by SEDDS formulation2019
- Author(s)
  Nao Kato, Keisuke Ueda, Kenjirou Higashi, Kunikazu Moribe
- Organizer
  新製剤技術とエンジニアリングを考える会第１７回講演会
- Data Source
  KAKENHI-PROJECT-19K16334
[Presentation] Effect of the composition of drug/polymer/surfactant ternary solid dispersion on the formation of amorphous probucol nanoparticle from aqueous dispersion2019
- Author(s)
  Zhijing Zhao, Keisuke Ueda, Kenjirou Higashi, Kunikazu Moribe
- Organizer
  第25回創剤フォーラム若手研究会
- Data Source
  KAKENHI-PROJECT-19K16334
[Presentation] Glibenclamide 非晶質ナノ粒子の調製条件がナノ粒子の物理的安定性に及ぼす影響2019
- Author(s)
  森川千佳子, 植田圭祐, 東顕二郎, 森部久仁一
- Organizer
  製剤機械技術学会第29回大会
- Data Source
  KAKENHI-PROJECT-19K16334
[Presentation] Effect of molecular state of ternary solid dispersion on the physical property and stability of amorphous drug nanoparticles formed by aqueous dispersion2019
- Author(s)
  Zhao, Z., Katai, H., Ueda, K., Higashi, K., Moribe, K.
- Organizer
  The 1st Pharmaceutial Sciences Asia Conference 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06592
[Presentation] ドキソルビシン封入リポソームの形態変化：メカニズムの解明2019
- Author(s)
  西村公樹,植田圭祐, 東顕二郎, 森部久仁一
- Organizer
  日本薬剤学会34年会
- Data Source
  KAKENHI-PROJECT-19K16334
[Presentation] Effect of surfactant in ternary solid dispersion on the formation of amorphous probucol nanoparticles by aqueous dispersion2019
- Author(s)
  Zhao, Z., Ueda, K., Higashi, K., Moribe, K.
- Organizer
  The 3rd Workshop for Japan-Korea Young Scientists on Pharmaceutics
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06592
[Presentation] 固体分散体の水接触前後の分子状態がnifedipine溶出性に及ぼす影響2019
- Author(s)
  岡田ひとみ, 植田圭祐, 東顕二郎 , 森部久仁一
- Organizer
  第63回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-19K16334
[Presentation] structural evaluation of solid dispersion of carbamazepine and alpha-glucosl rutin by computational chemistry2019
- Author(s)
  馬梟寒, 藤崎彩花, 植田圭祐, 東顕二郎, 福澤薫, 米持悦生, 森部久仁一
- Organizer
  日本薬剤学会34年会
- Data Source
  KAKENHI-PROJECT-19K16334
[Presentation] Molecular-level understanding of stabilization mechanism of amorphous cyclosporin A nanosuspension prepared by wet bead milling with Pluronic F1272018
- Author(s)
  Ziqiao Chen, Keisuke Ueda, Kenjirou Higashi, Kunikazu Moribe
- Organizer
  第35回製剤と粒子設計シンポジウム
- Data Source
  KAKENHI-PROJECT-18K06592
[Presentation] 難水溶性薬物の経口吸収改善を目的とした薬物濃縮相形成型固体分散体製剤の設計2018
- Author(s)
  植田圭祐
- Organizer
  日本薬剤学会経口吸収フォーカスグループ第 8 回合宿討論会
- Data Source
  KAKENHI-PROJECT-16K18859
[Presentation] SMEDDS製剤の物性がfenofibrate経口吸収性に及ぼす影響2018
- Author(s)
  砂塚祐志、植田圭祐、東顕二郎、森部久仁一
- Organizer
  第33年会日本薬剤学会
- Data Source
  KAKENHI-PROJECT-16K18859
[Presentation] Effect of preparation method of ternary solid dispersion on the evolution of amorphous probucol nanoparticles formed after aqueous dispersion2018
- Author(s)
  Zhijing Zhao, Hiroaki Katai, Keisuke Ueda, Kenjirou Higashi, Kunikazu Moribe
- Organizer
  製剤機械技術学会第28回大会
- Data Source
  KAKENHI-PROJECT-18K06592
[Presentation] 薬物-ポリマー分子間相互作用がカルバマゼピン非晶質固体分散体の物理的安定性に及ぼす影響2018
- Author(s)
  石塚優也、植田圭祐、武田順平、辛島正俊、東顕二郎、池田幸弘、森部久仁一
- Organizer
  第33年会日本薬剤学会
- Data Source
  KAKENHI-PROJECT-16K18859
[Presentation] コアシェル構造を有するオレイン酸コレステリル/g-シクロデキストリンナノ粒子の調製2018
- Author(s)
  石本有沙, 植田圭祐, 笹子浩史, 東顕二郎, 神山和夫, 森部久仁一
- Organizer
  第３５回シクロデキストリンシンポジウム
- Data Source
  KAKENHI-PROJECT-18K06592
[Presentation] Hypromellose/Eudragit S 100含有3成分固体分散体を用いたnifedipine溶出改善及びそのメカニズム解明2018
- Author(s)
  植田圭祐、山添千里、東顕二郎、川上亘作、森部久仁一
- Organizer
  第33年会日本薬剤学会
- Data Source
  KAKENHI-PROJECT-16K18859
[Presentation] Preparation of cholesteryl oleate/g-cyclodextrin nanoparticles by solvent diffusion method2018
- Author(s)
  Ishimoto, A., Ueda, K., Higashi, K., Sasako, H., Koyama, K., Moribe, K.
- Organizer
  The 19th International Cyclodextrin Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06592
[Presentation] Eudragit Eの液中構造が薬物可溶化能に及ぼす影響2018
- Author(s)
  岡本　裕太、植田　圭祐、東　顕二郎、森部　久仁一
- Organizer
  日本薬剤学会　製剤創剤セミナー
- Data Source
  KAKENHI-PROJECT-16K08190
[Presentation] Application of AFM for structural and morphological evaluation of drug-incorporated nanoparticles2017
- Author(s)
  Moribe, K., Egami, K., Takahashi, N., Ueda K., Higashi, K.
- Organizer
  Gordon Research Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08190
[Presentation] 加熱溶融混錬により調製したnifedipine/HPMC-AS固体分散体の溶出性評価2017
- Author(s)
  山添千里, 植田圭祐, 東顕二郎, 川上亘作, 森部久仁一
- Organizer
  日本薬剤学会第32年会
- Data Source
  KAKENHI-PROJECT-16K18859
[Presentation] AFMを用いた水溶液中におけるEudragit® Eのナノ構造体評価2017
- Author(s)
  岡本裕太, 植田圭祐, 東顕二郎, 森部久仁一
- Organizer
  第61回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-16K08190
[Presentation] Nifedipine/Hypromellose/Eudragit S100三成分固体分散体の調製による薬物溶出性改善メカニズムの解明2017
- Author(s)
  山添千里, 植田圭祐, 東顕二郎, 森部久仁一
- Organizer
  第34回製剤と粒子設計シンポジウム
- Data Source
  KAKENHI-PROJECT-16K18859
[Presentation] HPMCの分子量が薬物ナノ結晶製剤の経口吸収性に及ぼす影響2017
- Author(s)
  岩井隆暁, 植田圭祐, 東顕二郎, 森部久仁一
- Organizer
  新製剤技術とエンジニアリングを考える会第15回技術講演会
- Data Source
  KAKENHI-PROJECT-16K18859
[Presentation] 難水溶性薬物の溶出性向上を目的としたポリマーブレンドの応用2017
- Author(s)
  植田圭祐, 大八木直子, 東顕二郎, 森部久仁一
- Organizer
  第33回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-16K18859
[Presentation] 加熱混練過程における薬物ナノ結晶形成メカニズムの解明2017
- Author(s)
  植田圭祐, 尾曲克彦, 東顕二郎, 井上元基, 深水啓朗, 森部久仁一
- Organizer
  日本薬剤学会第32年会
- Data Source
  KAKENHI-PROJECT-16K18859
[Presentation] 固体NMRによる混合粉砕過程における薬物ナノ結晶及び非晶質形成評価2016
- Author(s)
  植田圭祐,東顕二郎,森部久仁一
- Organizer
  第33回製剤と粒子設計シンポジウム
- Place of Presentation
  ホテルメトロポリタン長野（長野県長野市）
- Year and Date
  2016-10-27
- Data Source
  KAKENHI-PROJECT-16K18859
[Presentation] 固体NMRのよる混合粉砕物中の薬物ナノ結晶サイズ評価2016
- Author(s)
  植田圭祐,東顕二郎,森部久仁一
- Organizer
  日本薬剤学会第31年会
- Place of Presentation
  長良川国際会議場（岐阜県岐阜市）
- Year and Date
  2016-05-19
- Data Source
  KAKENHI-PROJECT-16K18859
[Presentation] AFM observation of morphological changes of doxorubicin-loaded liposomes2016
- Author(s)
  東顕二郎, 高橋　尚樹, 植田圭祐, 山本恵司, 森部久仁一
- Organizer
  第59回顕微鏡学会シンポジウム
- Place of Presentation
  東京
- Year and Date
  2016-11-18
- Data Source
  KAKENHI-PROJECT-16K08190
[Presentation] 薬物過飽和溶解量の限界値2016
- Author(s)
  植田圭祐
- Organizer
  日本薬剤学会第7 回経口吸収フォーカスグループ合宿討論会
- Place of Presentation
  KKRホテル熊本（熊本県熊本市）
- Year and Date
  2016-12-15
- Data Source
  KAKENHI-PROJECT-16K18859
[Presentation] Characterization and formulation optimization of grinding-induced drug nanoparticle using solid-state NMR relaxometry2016
- Author(s)
  Ueda K., Higashi K., Moribe K.
- Organizer
  2016 AAPS Annual Meeting and Exposition
- Place of Presentation
  Denver, CO (USA)
- Year and Date
  2016-11-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18859
[Presentation] AFM及びcryo-TEMを用いたドキソルビシン封入リポソームの形態評価2016
- Author(s)
  森部久仁一、高橋尚希、植田圭祐、東顕二郎、山本恵司
- Organizer
  第32回日本DDS学会学術集会
- Place of Presentation
  静岡
- Year and Date
  2016-06-30
- Data Source
  KAKENHI-PROJECT-16K08190
[Presentation] Mechanistic study of drug crystallization inhibition by HPMC-AS using solution-state NMR measurements2016
- Author(s)
  Ueda K., Higashi K., Moribe K.
- Organizer
  51st AAPS Arden Conference: Contemporary Perspectives on Developing Amorphous Pharmaceuticals
- Place of Presentation
  Baltimore, MD (USA)
- Year and Date
  2016-04-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18859
[Presentation] 難溶解性薬物の吸収改善の現状と分子レベルでの考察2016
- Author(s)
  植田圭祐
- Organizer
  創剤研究コンソーシアム2016年度第1回研究会
- Place of Presentation
  立命館大学東京キャンパス（東京都千代田区）
- Invited
- Data Source
  KAKENHI-PROJECT-16K18859
[Presentation] Drug Supersaturation to Improve Oral Absorption of Poorly Water-Soluble Drugs2016
- Author(s)
  Ueda K.
- Organizer
  The 1st Workshop for Japan-Korea Young Scientists on Pharmaceutics
- Place of Presentation
  京都教育文化センター（京都府京都市）
- Year and Date
  2016-06-24
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18859

1. MORIBE KUNIKAZU (50266350)

# of Collaborated Projects: 7 results

# of Collaborated Products: 109 results
2. Higashi Kenjirou (40451760)

# of Collaborated Projects: 7 results

# of Collaborated Products: 108 results
3. 米持悦生 (40201090)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 福澤薫 (50718244)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 今村比呂志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ueda Keisuke 植田 圭祐

Research Projects

Research Products

Co-Researchers

NMR及び高速AFMによる分子レベルでの物性評価に基づく高活性な脂質ナノ粒子製剤開発Principal Investigator

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Elucidation of destabilization mechanism of drug amorphous nanosuspension for middle-molecule drug development

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Development of drug-rich phase-coexisting lipid nanoparticle formulations based on elucidation of molecular mechanism of liquid-liquid phase separation phenomenon of drugsPrincipal Investigator

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Structural evaluation of solid-liquid interface of drug nanoamorphous by suspended-state NMR

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Drug dissolution mechanism based on evaluation of polymer structure, mobility, and intermolecular interaction

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Development of drug-rich phase-forming solid dispersion formulations based on molecular-level characterization by NMRPrincipal Investigator

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Design of drug amorphous nanosuspension to achieve a pharmaceutical formulation of poorly water-soluble drug

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Refined structural analysis and mechanical property of drug nano-formulation by AFM in aqueous meida

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Development of drug amorphous/nanocrystal hybrid formulation based on the molecular-level evaluation by solid-state NMRPrincipal Investigator

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[Book] ナノ・マイクロ微粒子の分散評価技術 核磁気共鳴（分担）2020

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[Book] 粉体の表面処理・複合化技術集大成2018

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[Book] 最新の薬剤学知見と世界の開発状況をふまえた 前臨床／臨床医薬品開発の展望と戦略2018

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[Book] 難水溶性薬物の経口製剤化技術最前線(固体分散体の過飽和溶解)2016

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Publisher

Ueda Keisuke 植田圭祐

[Book] ナノ・マイクロ微粒子の分散評価技術　核磁気共鳴（分担）2020

[Book] 最新の薬剤学知見と世界の開発状況をふまえた　前臨床／臨床医薬品開発の展望と戦略2018