Yasuda Satoshi 安田賢司

… Alternative Names

Satoshi Yasuda 安田賢司

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Researcher Number	40792081
Other IDs	https://orcid.org/0000-0003-3555-1083
Affiliation (Current)	2025: 千葉大学, 量子生命構造創薬センター, 特任准教授
Affiliation (based on the past Project Information) *help	2025: 千葉大学, 量子生命構造創薬センター, 特任准教授 2022 – 2024: 千葉大学, 大学院理学研究院, 特任准教授 2017 – 2021: 千葉大学, 大学院理学研究院, 特任助教
Review Section/Research Field	Principal Investigator Basic Section 43040:Biophysics-related / Biophysics Except Principal Investigator Basic Section 48040:Medical biochemistry-related
Keywords	Principal Investigator 形態計測学的アプローチ / 溶媒和エントロピー / 自由エネルギー関数 / 水素結合 / 分子動力学シミュレーション / V-ATPase / 水和エネルギー / V1-ATPアーぜ / V1ATPase / 分子モーター … More / 水和エントロピー / V1-atpase / 水のエントロピー / 形態計測学的手法 / ATP加水分解 / F1-ATPase / V1-ATPase / 回転分子モーター / ATP駆動タンパク質 / ロドプシン / 膜タンパク質 / 熱安定化 / 共溶媒効果 / エントロピー / 積分方程式論 / 統計熱力学 / アミノ酸置換 / 耐熱化 / サーモフィリックロドプシン … More Except Principal Investigator リガンド開発 / 計算科学 / クライオ電子顕微鏡単粒子解析 / プロテアーゼ活性化受容体 / Gタンパク質共役受容体 Less

プロテアーゼ活性化受容体の構造に基づく合理的新規抗凝固薬の探索
- Principal Investigator
  
  浅田秀基
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  Kyoto University
Elucidation of the Ion Transport Mechanism of Sodium-Transporting V-ATPase Based on Statistical ThermodynamicsPrincipal Investigator
- Principal Investigator
  
  安田賢司
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43040:Biophysics-related
- Research Institution
  Chiba University
Elucidation of the Rotational Mechanism of V1-ATPase Based on Liquid TheoryPrincipal Investigator
- Principal Investigator
  
  Yasuda Satoshi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43040:Biophysics-related
- Research Institution
  Chiba University
Creation of Thermostabilized Mutant for Rhodopsin Based on Statistical ThermodynamicsPrincipal Investigator
- Principal Investigator
  
  Satoshi Yasuda
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biophysics
- Research Institution
  Chiba University

All 2024 2023 2022 2021 2020 2019 2018 2017

All Journal Article Presentation

[Journal Article] Cryo-EM structure of P-glycoprotein bound to triple elacridar inhibitor molecules2024
- Author(s)
  Hamaguchi-Suzuki Norie、Adachi Naruhiko、Moriya Toshio、Yasuda Satoshi、Kawasaki Masato、Suzuki Kano、Ogasawara Satoshi、Anzai Naohiko、Senda Toshiya、Murata Takeshi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 709 Pages: 149855-149855
- DOI
  10.1016/j.bbrc.2024.149855
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06108, KAKENHI-PROJECT-21K19348, KAKENHI-PROJECT-21H03065
[Journal Article] A Methodology for Creating Thermostabilized Mutants of GPCR by Combining Statistical Thermodynamics and Evolutionary Molecular Engineering2023
- Author(s)
  Yasuda Satoshi
- Journal Title
  
  Seibutsu Butsuri
  
  Volume: 63 Issue: 5 Pages: 252-256
- DOI
  10.2142/biophys.63.252
- ISSN
  0582-4052, 1347-4219
- Language
  Japanese
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06108
[Journal Article] Physical pictures of rotation mechanisms of F1- and V1-ATPases: Leading roles of translational, configurational entropy of water2023
- Author(s)
  Yasuda Satoshi、Hayashi Tomohiko、Murata Takeshi、Kinoshita Masahiro
- Journal Title
  
  Frontiers in Molecular Biosciences
  
  Volume: 10 Pages: 1-23
- DOI
  10.3389/fmolb.2023.1159603
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K03547, KAKENHI-PROJECT-21K06108, KAKENHI-PROJECT-21H02409
[Journal Article] A methodology for creating mutants of G‐protein coupled receptors stabilized in active state by combining statistical thermodynamics and evolutionary molecular engineering2022
- Author(s)
  Yamamoto Taisei、Yasuda Satoshi、Kasai Rinshi S.、Nakano Ryosuke、Hikiri Simon、Sugaya Kanna、Hayashi Tomohiko、Ogasawara Satoshi、Shiroishi Mitsunori、Fujiwara Takahiro K.、Kinoshita Masahiro、Murata Takeshi
- Journal Title
  
  Protein Science
  
  Volume: 31 Issue: 10
- DOI
  10.1002/pro.4425
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06108, KAKENHI-PROJECT-22K03547, KAKENHI-PLANNED-21H05252, KAKENHI-PROJECT-20H03225, KAKENHI-PLANNED-18H05424, KAKENHI-PLANNED-18H05425
[Journal Article] A methodology for creating thermostabilized mutants of G‐protein coupled receptors by combining statistical thermodynamics and evolutionary molecular engineering2022
- Author(s)
  Sugaya Kanna、Yasuda Satoshi、Sato Shingo、Sisi Chen、Yamamoto Taisei、Umeno Daisuke、Matsuura Tomoaki、Hayashi Tomohiko、Ogasawara Satoshi、Kinoshita Masahiro、Murata Takeshi
- Journal Title
  
  Protein Science
  
  Volume: 31 Issue: 9
- DOI
  10.1002/pro.4404
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06108, KAKENHI-PROJECT-22K03547, KAKENHI-PLANNED-18H05425, KAKENHI-PLANNED-21H05228
[Journal Article] サーモフィリックロドプシンとキサントロドプシンの熱安定性の大きな違いに対する統計熱力学解析2021
- Author(s)
  安田賢司、林智彦、村田武士、木下正弘
- Journal Title
  
  アグリバイオ
  
  Volume: 4 Pages: 61-66
- Data Source
  KAKENHI-PROJECT-17K15099
[Journal Article] Theoretical identification of thermostabilizing amino acid mutations for G-protein-coupled receptors2020
- Author(s)
  Takeshi Murata、Satoshi Yasuda、Tomohiko Hayashi、Masahiro Kinoshita
- Journal Title
  
  Biophysical Reviews
  
  Volume: － Issue: 2 Pages: 323-332
- DOI
  10.1007/s12551-020-00678-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K15099, KAKENHI-PROJECT-19K14674, KAKENHI-PROJECT-17H03663, KAKENHI-PLANNED-18H05425
[Journal Article] サーモフィリックロドプシンの極めて高い熱安定性に関する統計熱力学的解析2020
- Author(s)
  安田賢司、林智彦、村田武士、木下正弘
- Journal Title
  
  月刊「細胞」
  
  Volume: 52 Pages: 37-41
- Data Source
  KAKENHI-PROJECT-17K15099
[Journal Article] Methodology for Further Thermostabilization of an Intrinsically Thermostable Membrane Protein Using Amino Acid Mutations with Its Original Function Being Retained2020
- Author(s)
  Yasuda Satoshi、Akiyama Tomoki、Nemoto Sayaka、Hayashi Tomohiko、Ueta Tetsuya、Kojima Keiichi、Tsukamoto Takashi、Nagatoishi Satoru、Tsumoto Kouhei、Sudo Yuki、Kinoshita Masahiro、Murata Takeshi
- Journal Title
  
  Journal of Chemical Information and Modeling
  
  Volume: 60 Issue: 3 Pages: 1709-1716
- DOI
  10.1021/acs.jcim.0c00063
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K15099, KAKENHI-PROJECT-19K14674, KAKENHI-PROJECT-19K16090, KAKENHI-PLANNED-18H05425, KAKENHI-PUBLICLY-19H04727, KAKENHI-PUBLICLY-19H05396, KAKENHI-PROJECT-17H03663, KAKENHI-PROJECT-18H02082, KAKENHI-PROJECT-18H02411
[Journal Article] How Does a Microbial Rhodopsin RxR Realize Its Exceptionally High Thermostability with the Proton-Pumping Function Being Retained?2020
- Author(s)
  Hayashi Tomohiko、Yasuda Satoshi、Suzuki Kano、Akiyama Tomoki、Kanehara Kanae、Kojima Keiichi、Tanabe Mikio、Kato Ryuichi、Senda Toshiya、Sudo Yuki、Murata Takeshi、Kinoshita Masahiro
- Journal Title
  
  The Journal of Physical Chemistry B
  
  Volume: 124 Issue: 6 Pages: 990-1000
- DOI
  10.1021/acs.jpcb.9b10700
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K15099, KAKENHI-PROJECT-19K14674, KAKENHI-PROJECT-19K16090, KAKENHI-PLANNED-18H05425, KAKENHI-PUBLICLY-19H04727, KAKENHI-PUBLICLY-19H05396, KAKENHI-PROJECT-17H03663, KAKENHI-PROJECT-18H02411, KAKENHI-PROJECT-17H06264
[Journal Article] サーモフィリックロドプシンとキサントロドプシンの熱安定性の大きな違いに対する統計熱力学解析2020
- Author(s)
  安田賢司、林智彦、村田武士、木下正弘
- Journal Title
  
  アグリバイオ
  
  Volume: 4 Pages: 61-67
- Data Source
  KAKENHI-PROJECT-17K15099
[Journal Article] Elucidation of cosolvent effects thermostabilizing water-soluble and membrane proteins2020
- Author(s)
  Yasuda Satoshi、Kazama Kazuki、Akiyama Tomoki、Kinoshita Masahiro、Murata Takeshi
- Journal Title
  
  Journal of Molecular Liquids
  
  Volume: 301 Pages: 112403-112403
- DOI
  10.1016/j.molliq.2019.112403
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K15099, KAKENHI-PLANNED-18H05425, KAKENHI-PROJECT-17H03663
[Journal Article] Analyses based on statistical thermodynamics for large difference between thermophilic rhodopsin and xanthorhodopsin in terms of thermostability2019
- Author(s)
  Yasuda Satoshi、Hayashi Tomohiko、Kajiwara Yuta、Murata Takeshi、Kinoshita Masahiro
- Journal Title
  
  The Journal of Chemical Physics
  
  Volume: 150 Issue: 5 Pages: 055101-055101
- DOI
  10.1063/1.5082217
- NAID
  40022492153
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K15099, KAKENHI-PROJECT-17H03663, KAKENHI-PLANNED-18H05425
[Presentation] Physical pictures of rotation mechanisms of F1- and V1-ATPases: Leading roles of translational, configurational entropy of water2023
- Author(s)
  Satoshi Yasuda, Tomohiko Hayashi, Takeshi Murata and Masahiro Kinoshita
- Organizer
  第61回日本生物物理学会年会
- Data Source
  KAKENHI-PROJECT-21K06108
[Presentation] クライオ電子顕微鏡構造解析と高速AFM観察から見えてきたABCトランスポーター（P-gp）の構造ダイナミクス2023
- Author(s)
  濱口紀江、安達成彦、野中雄仁、喜多俊介、今野翔、金岡優依、守屋俊夫、川崎政人、安田賢司、安西尚彦、林良雄、前仲勝実、千田俊哉、小笠原諭、内橋貴之、村田武士
- Organizer
  第23回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-21K06108
[Presentation] Structural analysis of the multidrug efflux transporter P-glycoprotein bound by an inhibitor2023
- Author(s)
  濱口紀江、安達成彦、守屋俊夫、川崎政人、安田賢司、安西尚彦、千田俊哉、小笠原諭、村田武士
- Organizer
  Federation of the Asian and Oceanian Physiological Societies Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06108
[Presentation] Creation of ATP synthase with multiple torque generating units2023
- Author(s)
  Hiroshi Ueno, Riku Marui, Naruhiko Adachi, Norie Hamaguchi, Toshio Moriya, Masato Kawasaki, Akihito Ikeda, Satomi Inaba, Satoshi Yasuda, Toshiya Senda, Takeshi Murata, Hiroyuki Noji
- Organizer
  第61回日本生物物理学会年会
- Data Source
  KAKENHI-PROJECT-21K06108
[Presentation] アミノ酸変異による最も耐熱性の高い外向きプロトンポンプ型ロドプシンの構築2023
- Author(s)
  安田賢司、秋山友希、木下正弘、村田武士
- Organizer
  量子生命科学会第5回大会
- Data Source
  KAKENHI-PROJECT-21K06108
[Presentation] 統計熱力学計算と進化分子工学を融合した GPCR 耐熱化置換体の構築手法の開発2022
- Author(s)
  安田賢司、菅谷幹奈、佐藤愼吾、藤木祐美、陳思思、林智彦、小笠原諭、木下正弘、村田武士
- Organizer
  第22回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-21K06108
[Presentation] 理論計算と進化分子工学の融合によるリガンド結合非依存的に活性型へシフトする GPCR 変異体のスクリーニング2022
- Author(s)
  山本大生、笠井倫志、肥喜里志門、藤原敬宏、中野僚介、菅谷幹奈、安田賢司、小笠原諭、白石充典、木下正弘、村田武士
- Organizer
  第22回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-21K06108
[Presentation] Further Thermo-Stabilization of Thermophilic Rhodopsin through Engineering in Intramembrane and Extramembrane Regions2019
- Author(s)
  Tomoki Akiyama, Naoki Kunishima, Masako Hirose, Sayaka Nemoto, Satoshi Yasuda, Yuki Sudo, Takeshi Murata
- Organizer
  第57回日本生物物理学会年会
- Data Source
  KAKENHI-PROJECT-17K15099
[Presentation] Theoretical Prediction of Thermostabilizing Mutations for GPCR: Identification of Hot-Spot Residues to be Mutated Common in Class A GPCRs2019
- Author(s)
  Satoshi Yasuda, Yuta Kajiwara, Yuki Takamuku, Nanao Suzuki, Yosuke Toyoda, Kazushi Morimoto, Ryoji Suno, So Iwata, Takuya Kobayashi, Takeshi Murata, Masahiro Kinoshita
- Organizer
  第57回日本生物物理学会年会
- Data Source
  KAKENHI-PROJECT-17K15099
[Presentation] The influence of cosolvent on thermal stability of membrane proteins2019
- Author(s)
  Kazuki Kazama, Satoshi Yasuda, Tomoki Akiyama, Masahiro Kinoshita, Takeshi Murata
- Organizer
  CBI学会2019年大会
- Data Source
  KAKENHI-PROJECT-17K15099
[Presentation] Analyses based on statistical thermodynamics for large difference between thermophilic rhodopsin and xanthorhodopsin in terms of thermostability2019
- Author(s)
  Satoshi Yasuda, Tomohiko Hayashi, Yuta Kajiwara, Takeshi Murata, Masahiro Kinoshita
- Organizer
  CBI学会2019年大会
- Data Source
  KAKENHI-PROJECT-17K15099
[Presentation] Theoretical Identification of Hot-Spot Residues to be Mutated Common in G Protein-Coupled Receptors of Class A2018
- Author(s)
  Satoshi Yasuda
- Organizer
  Biophysical Society 62nd Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15099
[Presentation] Physical origin of exceptionally high thermostability of thermophilic rhodopsin2018
- Author(s)
  Satoshi Yasuda, Tomohiko Hayashi, Yuta Kajiwara, Takeshi Murata, Masahiro Kinoshita
- Organizer
  第56回日本生物物理学会年会
- Data Source
  KAKENHI-PROJECT-17K15099
[Presentation] Statistical thermodynamics on the large difference between thermophilic rhodopsin and xanthorhodopsin in terms of thermostability2018
- Author(s)
  Satoshi Yasuda, Tomohiko Hayashi, Yuta Kajiwara, Takeshi Murata, and Masahiro Kinoshita
- Organizer
  The 79th Okazaki Conference
- Data Source
  KAKENHI-PROJECT-17K15099
[Presentation] Statistical thermodynamics for remarkably high thermal stability of thermophilic rhodopsin2018
- Author(s)
  Satoshi Yasuda
- Organizer
  The Second Symposium of Chiral Molecular Science and Technology in Chiba University -Advanced Materials Science, Biology & Nanophotonics in Chiba-
- Data Source
  KAKENHI-PROJECT-17K15099
[Presentation] 置換により多くのClass AのGタンパク質共役型を安定化するアミノ酸残基の理論的決定2017
- Author(s)
  安田賢司
- Organizer
  第５５回日本生物物理学会年会
- Data Source
  KAKENHI-PROJECT-17K15099
[Presentation] サーモフィリックロドプシンの極めて高い熱安定性に対する統計熱力学的解析2017
- Author(s)
  安田賢司
- Organizer
  日本生体エネルギー研究会第43回討論会
- Data Source
  KAKENHI-PROJECT-17K15099
[Presentation] 統計熱力学に基づいたG蛋白質共役型受容体耐熱化アミノ酸変異体の理論的予測2017
- Author(s)
  安田賢司
- Organizer
  第17回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-17K15099

1. 井上雅郎 (80993633)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 浅田秀基 (20399041)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 堂浦智裕 (00745226)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 足立誠 (30335244)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. Im Dohyun (50721883)

# of Collaborated Projects: 1 results

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6. 林智彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Yasuda Satoshi 安田 賢司

Satoshi Yasuda 安田 賢司

Research Projects

Research Products

Co-Researchers

プロテアーゼ活性化受容体の構造に基づく合理的新規抗凝固薬の探索

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the Ion Transport Mechanism of Sodium-Transporting V-ATPase Based on Statistical ThermodynamicsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the Rotational Mechanism of V1-ATPase Based on Liquid TheoryPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Creation of Thermostabilized Mutant for Rhodopsin Based on Statistical ThermodynamicsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Cryo-EM structure of P-glycoprotein bound to triple elacridar inhibitor molecules2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A Methodology for Creating Thermostabilized Mutants of GPCR by Combining Statistical Thermodynamics and Evolutionary Molecular Engineering2023

Author(s)

Journal Title

DOI

ISSN

Language

Data Source

[Journal Article] Physical pictures of rotation mechanisms of F1- and V1-ATPases: Leading roles of translational, configurational entropy of water2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A methodology for creating mutants of G‐protein coupled receptors stabilized in active state by combining statistical thermodynamics and evolutionary molecular engineering2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A methodology for creating thermostabilized mutants of G‐protein coupled receptors by combining statistical thermodynamics and evolutionary molecular engineering2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] サーモフィリックロドプシンとキサントロドプシンの熱安定性の大きな違いに対する統計熱力学解析2021

Author(s)

Journal Title

Data Source

[Journal Article] Theoretical identification of thermostabilizing amino acid mutations for G-protein-coupled receptors2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] サーモフィリックロドプシンの極めて高い熱安定性に関する統計熱力学的解析2020

Author(s)

Journal Title

Data Source

[Journal Article] Methodology for Further Thermostabilization of an Intrinsically Thermostable Membrane Protein Using Amino Acid Mutations with Its Original Function Being Retained2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] How Does a Microbial Rhodopsin RxR Realize Its Exceptionally High Thermostability with the Proton-Pumping Function Being Retained?2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] サーモフィリックロドプシンとキサントロドプシンの熱安定性の大きな違いに対する統計熱力学解析2020

Yasuda Satoshi 安田賢司

Satoshi Yasuda 安田賢司

[Presentation] 理論計算と進化分子工学の融合によるリガンド結合非依存的に活性型へシフトする GPCR 変異体のスクリーニング2022