OBA Toshiharu 大羽利治

Researcher Number	50008330
Other IDs
Affiliation *help	2014 : 中部大学, 応用生物学部, 教授 2007 : Nagoya City University, Graduate School of Medical Sciences, Departments of Cell Physiology, Associate professor 2005 – 2006 : 名古屋市立大学, 医学部, 助教授 1996 – 2001 : 名古屋市立大学, 医学部, 助教授 1992 : 名古屋市立大学, 医学部, 助教授 1988 – 1990 : 名古屋市立大学, 医学部, 助教授
Review Section/Research Field	Principal Investigator General physiology / Neurophysiology and muscle physiology Except Principal Investigator General pharmacology / Pediatrics
Keywords	Principal Investigator 筋小胞体 / システイン残基 / 活性酸素 / single channel current / SH基 / Caチャネル蛋白質 / シアニン系蛍光色素 / Ca チャネル / 骨格筋 / Transverse Tubule … More Except Principal Investigator カルシウムイオン / 筋小胞体 / リアノジン受容体 / 膜電位 / 骨格筋 / cardiac hypertrophy / クレアチンキナーゼ / カルシウム / calcium ion / 細胞内Ca2+ / Myopathy / Animal model / heart failure / Skeletal muscle / S4-S5リンカー / 相互作用 / クレアチンキナーゼ / 心肥大 / Membrane potential / モデル動物 / 活動電位 / Calcium / sarcoplasmic reticulum / 人工アミノ酸 / ryanodine receptor / Creatine kinase / 細胞内カルシウム / カルシウムチャネル / 心不全 / Action potential / ミオパチー / カルモジュリン / 不整脈 / 興奮収縮連関 / Ionized calcium Less

Elucidation of regulatory mechanisms of type 2 ryanodine receptors by introducing artificial amino acids
- Principal Investigator
  
  MURAYAMA Takashi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Juntendo University
Molecular mechanisms underlying abnormal functions in RyR2 complex in cardiac hypertrophy/heart failure
- Principal Investigator
  
  MURAYAMA Takashi
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Juntendo University
DO CYSTEINES LOCATED NEAR THE CHANNEL PORE OF THE RYANODINE RECEPTOR FUNCTION AS TARGET AMINO ACID FOR REACTIVE OXYGEN SPECIES?Principal Investigator
- Principal Investigator
  
  OBA Toshiharu
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  NAGOYA GITY UNIVERSITY
Study on the genetic mechanism underlying "hypocalcemic myopathy" using an animal model
- Principal Investigator
  
  ISHIKAWA Tatsuya
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Nagoya City University
CYSTEIN CONFORMATIONAL CHANGES ARE ASSOCIATED WITH INACTIVATION OF L-TYPE CALCIUM CHANNELPrincipal Investigator
- Principal Investigator
  
  OBA Toshiharu
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General physiology
- Research Institution
  Nagoya City University
活性酸素が生理条件下で筋損傷を発現する可能性に関するチャネル分子レベルでの研究Principal Investigator
- Principal Investigator
  
  大羽利治
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  Nagoya City University
骨格筋興奮-収縮連関と膜電位センサーの酸化還元反応の関与に関する電気生理学的研究Principal Investigator
- Principal Investigator
  
  大羽利治
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Institution
  Nagoya City University
Coupling of Action Potential of T-Tubule with Ca^<2+> Release form Sarcoplasmic Reticulum in Skeletal MusclePrincipal Investigator
- Principal Investigator
  
  OBA Toshiharu
- Project Period (FY)
  1988 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Neurophysiology and muscle physiology
- Research Institution
  Nagoya City University

All 2014 2008 2007 2006

All Journal Article Presentation

[Journal Article] Multifunctional GFP Tag2014
- Author(s)
  Murayama T, Kobayashi T
- Journal Title
  
  Methods Mol Biol
  
  Volume : 1177 Pages : 151-161
- DOI
  10.1007/978-1-4939-1034-2_12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590330
[Journal Article] Cellular redox state protects acetaldehyde-induced alteration in cardiomyocyte function by modifying Ca2+release from sarcoplasmic reticulum2008
- Author(s)
  Oba, Toshiharu
- Journal Title
  
  Am.J.Physiol.Heart Circ.Physiol. 294
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590227
[Journal Article] Cellular redox state protects acetaldchyde-induced alteration in cardiomyocyte function by modifying Ca2+ release from sarcoplasmic reticulum2008
- Author(s)
  Oba, Toshiharu
- Journal Title
  
  Am.J.Physiol.Heart Circ.Physiol. 294
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590227
[Journal Article] Cellular redox state protects acetaldehyde-induced alteration in cardiomyocyte function by modifying Ca^<2+> release from sarcoplasmic reticulum2008
- Author(s)
  Oba, T
- Journal Title
  
  Am J Physiol Heart Circ Physiol 294
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590227
[Presentation] Generation of the GFP-tagged type 1 ryanodine receptor mutants by transposon-based random insertion approach2008
- Author(s)
  Murayama, T, Kashiyama, T, Oyamada, H, Kobayashi, T, Kurebayashi, N, Sakurai, T
- Organizer
  Biophysical Society 52nd Annual Meeting
- Place of Presentation
  Long Beach, CA
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590227
[Presentation] 1型リアノジン受容体ドメイン間相互作用により賦活されたチャネル活性に対する酸化の効果2007
- Author(s)
  大羽利治
- Organizer
  第84回日本生理学会大会
- Place of Presentation
  大阪
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590227
[Presentation] Role of a cytoplasmic loop between M7b and M8 transmembrane helices of RyR1 in Ca^<2+> channel gating2007
- Author(s)
  Murayama, T, Oyamada, H, Oba, T, Oguchi, K, Kurebayashi, N
- Organizer
  Biophysical Society 51st Annual Meeting
- Place of Presentation
  Baltimore, MD
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590227
[Presentation] Postulated role of interdomain interactions within the type 1 ryanodine receptor in dysfunction of Ca^<2+> release channel in malignant hyperthermia2006
- Author(s)
  Murayama, T, Oyamada, H, Kurebayashi, N, Oba, T, Hara, H, Wakebe, K, Ikemoto, N, Ogawa, Y
- Organizer
  Biophysical Society 50th Annual Meeting
- Place of Presentation
  Salt Laky City, UT
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590227

1. HOZUMI Tetsh (10080102)

# of Collaborated Projects : 3results

# of Collaborated Products : 0results
2. MURAYAMA Takashi (10230012)

# of Collaborated Projects : 3results

# of Collaborated Products : 4results
3. KUREBAYASHI Nagomi (50133335)

# of Collaborated Projects : 2results

# of Collaborated Products : 3results
4. SAKAMOTO Kensaku (50240685)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
5. MIURA Yutaka (90285198)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
6. ISHIKAWA Tatsuya (80080117)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
7. FUJIMOTO Shinji (60238615)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
8. 中郡昭人 (50236824)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results

OBA Toshiharu 大羽 利治

Research Projects

Research Products

Co-Researchers

Elucidation of regulatory mechanisms of type 2 ryanodine receptors by introducing artificial amino acids

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular mechanisms underlying abnormal functions in RyR2 complex in cardiac hypertrophy/heart failure

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

DO CYSTEINES LOCATED NEAR THE CHANNEL PORE OF THE RYANODINE RECEPTOR FUNCTION AS TARGET AMINO ACID FOR REACTIVE OXYGEN SPECIES?Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study on the genetic mechanism underlying "hypocalcemic myopathy" using an animal model

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

CYSTEIN CONFORMATIONAL CHANGES ARE ASSOCIATED WITH INACTIVATION OF L-TYPE CALCIUM CHANNELPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

活性酸素が生理条件下で筋損傷を発現する可能性に関するチャネル分子レベルでの研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

骨格筋興奮-収縮連関と膜電位センサーの酸化還元反応の関与に関する電気生理学的研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

Coupling of Action Potential of T-Tubule with Ca^<2+> Release form Sarcoplasmic Reticulum in Skeletal MusclePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Multifunctional GFP Tag2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cellular redox state protects acetaldehyde-induced alteration in cardiomyocyte function by modifying Ca2+release from sarcoplasmic reticulum2008

Author(s)

Journal Title

Data Source

[Journal Article] Cellular redox state protects acetaldchyde-induced alteration in cardiomyocyte function by modifying Ca2+ release from sarcoplasmic reticulum2008

Author(s)

Journal Title

Description

Data Source

[Journal Article] Cellular redox state protects acetaldehyde-induced alteration in cardiomyocyte function by modifying Ca^<2+> release from sarcoplasmic reticulum2008

Author(s)

Journal Title

Description

Data Source

[Presentation] Generation of the GFP-tagged type 1 ryanodine receptor mutants by transposon-based random insertion approach2008

Author(s)

Organizer

Place of Presentation

Description

Data Source

[Presentation] 1型リアノジン受容体ドメイン間相互作用により賦活されたチャネル活性に対する酸化の効果2007

Author(s)

Organizer

Place of Presentation

OBA Toshiharu 大羽利治