AKASAKA Kazuyuki 赤坂一之

Researcher Number	50025368
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Affiliation (based on the past Project Information) *help	2017: 近畿大学, 先端技術総合研究所, 教授 2014: 近畿大学, 先端技術総合研究所, 客員教授 2012 – 2014: 近畿大学, 先端技術総合研究所, 教授 2002 – 2007: 近畿大学, 生物理工学部, 教授 2001 – 2003: 神戸大学, 自然科学研究科, 教授 … More 1997 – 2000: 神戸大学, 大学院・自然科学研究科, 教授 1998: 神戸大学, 大学院自然科学研究科, 教授 1992 – 1996: KOBE UNIVERSITY PROFESSOR, 理学部, 教授 1986 – 1991: 京都大学, 理学部, 助教授 1986: 京大, 理学部, 助教授 Less
Review Section/Research Field	Principal Investigator Biophysics / Science and Engineering / 生物物性学 / Structural biochemistry / Physical chemistry / 構造化学 Except Principal Investigator Biophysics / Biophysics / 物理化学一般 / 広領域 / Organic chemistry / 応用生物化学・栄養化学 / Anesthesiology/Resuscitation studies
Keywords	Principal Investigator NMR / 高圧NMR / BPTI / high pressure NMR / 化学シフト / 蛋白質 / 高圧 / 低温変性 / 温度ジャンプ / 水素結合 … More / 圧力変性 / 円二色性 / ミオグロビン / 二次元NMR / 主鎖コンフォメーション / 揺らぎ / NOE / 内部運動 / 活性化体積 / 圧力解離 / ニワトリリゾチーム / SSI / リゾチーム / 水和 / タンパク質 / 相転移 / リボヌクレアーゼA / マイクロ波 / Subtilisin inhibitor / Deuterium NMR / Site-directed mutagenesis / Stable isotope labeling of proteins / Internal motions in proteins / 微生物培養 / 放線菌 / 重水素化 / トリプトファン / 重水素化タンパク質 / 個体タンパク質の水和 / プロテアーゼインヒビター / 酵素-阻害剤相互作用 / ズブチリシンインヒビター / 重水素NMR / 遺伝子工学 / タンパク質の同位体標識 / タンパク質の内部運動 / thermodynamic stability of transthyretin / transthyretin mutant / activation volume for dissociation / pressure dissociation of protofibrils / high pressure fluorescence / pressure-jump NMR / hen lysozyme / amyloid protofibril / 原子間顕微鏡 / ニワトリリゾチーム変異体 / トランスサイレチンの変異型 / プロトフィブリル解離の活性化体 / 圧力によるプロトフィブリルの解 / ニワトリリゾチームのS-S / トランスサイレチンの熱力学安定 / 変異型トランスサイレチン / 解離の活性化体積 / プロトフィブリルの圧力解離 / 高圧蛍光 / 圧力ジャンプNMR / アミロイドプロトフィブリル / enzyme function / flexibility / cavity / compressibility / dihydrofolate reductase / 蛋白質立体構造 / モジュール / NMR化学シフト / 原子間の空隙 / "open"構造 / 酵素機能 / ゆらぎ / 原子間の空間 / 圧縮率 / ジヒドロ葉酸還元酵素 / local unfolding / conformational change / hydrogen bond / 15N chemical shift / protein structure / 立体構造 / 核オーバーハウザー効果 / 主鎖コンフォーメーション / 1H pressure shift / conformational flexibility / 13C pressure shift / shortening of hydrogen bond / 15N pressure shift / 牛脾臓トリプシンインヒビター / N-15 NMR / ウシ脾臓トリブシンインヒビター / PROTEIN STRUCTIRE / STRUCTURAL CHANGES / DENATURATION / PRESSURE JUMP / HIGH PRESSURE / 小角x線散乱 / 熱力学 / Ribonuclease A. / 高圧変性 / プロトンNMR / ケト-エノール平衡 / 蛋白質構造 / 蛋白質変性 / 構造変化 / 変性 / 圧力ジャンプ / denaturation by methanol / temperature jump / pressure denaturation / cold denaturation / circular dichroism / x ray scattering / X線小角散乱 / S-S結合 / タンパク質の変性 / タンパク質の構造 / 膜融合ペプチド / Cytochrome c / Streptomyces Subtilisin Inhibitor / X線溶液散乱 / リボヌクレアーゼ / サチライシンインヒビター / シトクロームC / メタノール変性 / 円二色性分光 / x線溶液散乱 / ^<31>PNMR / ^1HNMR / recAタンパク質と一重鎖DNAとの結合 / recAタンパク質とATP-γ-Sとの結合 / recAタンパク質のカルボキシル末端断片 / recAタンパク質の内部運動領域 / RNase A / タンパク質高次構造の崩れ / タンパク質の巻き戻り / 生体高分子の相転移 / 温度ジャンプNMR / 自己会合 / 一重鎖DNA / ATP-δ-S / recAタンパク質 / 活性化圧縮率 / プロトフィブリル / アミロイド / SS結合欠損変異 / アミロイド線維の成長機構 / 部分モル体積変化 / シード / 熱変性 / プロトフィブリル形成 / アミロイド線維 / 遅い構造の揺らぎ / 加圧下の立体構造解析 / 構造揺らぎの可視化 / ユービキチンの構造揺らぎ / キャビティーの進化的設計 / キャビティーの水和 / キャビティー計算プログラム / 分子内キャビティー / 可変圧力NMR / 局所変性構造 / 準安定構造 / 熱励起構造 / NEDD8 / ユビキチン / グルマリン / バクテリオロドプシン / メリチン / スピン緩和 / ヘリックス / 比熱変化 / 体積変化 / リボクヌレアーゼA / アポミオグロビン / 高次構造 / 抵温変性 / 温度ジュンプ / 高次構造形成 / 金属タンパク質 / タンパク質の熱変性 / 液晶 / マイクロ波加熱 / リボヌクレア-ゼA / タンパク質変性 / タンパク質構造転移 / 状態相関二次元NMR / アンフォールディング … More Except Principal Investigator 高圧NMR / NMR / 遺伝子工学 / 揺らぎ / プロテアーゼインヒビター / PrP106-126 / NGF / high pressure NMR / 自然と人工 / 産業経済 / gene engineering / プロテアーゼ・インヒビター / 核磁気共鳴 / 蛋白質 / 抗体 / 準安定状態 / 圧力効果 / 抗原認識機構 / タンパク質 / Rayleigh scattering / equilibrium constant / local field / light scattering / binary solutions / chemical processes / density fluctuation / concentration fluctuation / 溶液 / ブリルアン散乱 / 二成分溶液系 / 電離 / 放射線化学反応 / レイリー散乱 / 平衝定数 / 局所電場 / 二成分溶液 / 光散乱法 / 化学反応 / 密度ゆらぎ / 濃度ゆらぎ / Interaction of Enzyme and its inhibitor / X-ray Crystallography of Protein / NMR of Proteins / Metallo-proteinase Inhibitor / Subtilisin Inhibitor / Proteinase Inhibitor / Site-directed Mutagenesis / Protein Engineering / 酵素ーインヒビター相互作用 / 酵素-インヒビター相互作用 / 金属プロテアーゼインヒビター / ズブチリシンインヒビター / 酵素-インヒビタ-相互作用 / 蛋白質のX線結晶解析 / 蛋白質の核磁気共鳴 / 金属プロテア-ゼインヒビタ- / ズブチリシンインヒビタ- / プロテア-ゼインヒビタ- / 蛋白質工学 / Stopped-flow method / Fluorescence titration / Enzyme-substrate interactions / Protease inhibitors / Amylases / Aminoacyl-tRNA synthetases / Proteases / ストレプトミセス・ズブチリシン・インヒビター(SSI) / 蛋白質蛍光 / 基質特異性 / グルコアミラーゼ / 酵素 / 誘導適合 / 酵素-基質相互作用 / 化学修飾 / 蛍光滴定法 / 核磁気共鳴法 / 酵素ー基質相互作用 / アミノアシルtRNA合成酵素 / ストップトフロー / 蛍光滴定 / 酵素一基質相互作用 / アミラーゼ / アミノアミルtRNA合成酵素 / プロテアーゼ / number theory / protein dynamics / causative mutation / CPMG relaxation / high-pressure / prion / ミリ秒揺らぎ / 高圧ジャンプ / 活性型立体構造 / 超高速パルスラベル / ユビキチン / リゾチーム / ダイナミクス / 安定性 / 緩和時間 / トレース公式 / パルス・ラベル / プリオン / 構造形成過程 / 生命科学理論 / 数論 / NMR緩和時間 / オリゴマー / 中間体 / ブリオン / 5-HT_3 Receptor / nACh Receptor / NMDA Receptor / GABA_A Receptor / volatile anesthetics / Gaseous Anesthetics / Anesthesia / 全身麻酔 / Ras / trk受容体 / キセノン / 亜酸化窒素 / リドカイン / プロカイン / 5-HT3受容体 / ブピバカイン / 麻酔薬 / GABAA受容体 / 5-HT_3受容体 / nACh受容体 / NMDA受容体 / GABA_A受容体 / 揮発性麻酔薬 / ガス麻酔薬 / 麻酔 / pressure-induced molecular deformation / activation volume / pressure effects / paracyclophane / high pressure quartz cell / high pressure NMR cell / 圧力変形 / 活性化体積 / パラシクロファン / 石英高圧セル / 高圧NMRセル / chaperonine / stopped-flow CD / protein denturation / X-ray solution scattering / molten globule / protein folding / 蛋白質非天然構造 / 疎水的相互作用 / 静電的相互作用 / 変性 / 蛋白質変性 / シャペロニン / ストップトフローCD / 蛋白質の変性 / X線溶液散乱 / モルテングロビュール / 蛋白質折り畳み / Leonardo Prima di Leonardo Exhibition / Bonsai and Artistic Photo Exhibition Prima di Leonardo Exhibition / Economy Session Diplomatic Mission Exhibition / Law / Humanity Session / Science Session / Siena Symposium / Kyoto / イメージ / 文化交流人類学 / 異文化交流 / 人間学 / 人間生活 / 学際領域研究 / レオナルド以前のレオナルド展覧会 / レオナルド以前展覧会 / 盆栽と写真展 / 岩倉使節団展 / 法・経済学部門 / 文学・芸術・人間学部門 / 自然科学部門 / シエナシンポジウム / 京都 / dipolar pattern / phase transition / temperature jump NMR / microwave / liquid crystal / 2D NMR / 双極子パタ-ン / 双極子パターン / 相転移 / 温度ジャンプNMR / マイクロ波 / 液晶 / 二次元NMR / Image of cities in 21st century / Environmental and resources constraint / Nature and artifact / Interdisciplinary research / Cross culture / Anthropology / Industrial economics / Nature and human life / クロスカルチャ- / ルネッサンス / 文学・芸術・生活 / 日伊関係 / 自然と人為 / EC統合 / 21世紀の都市のイメージ / 環境と資源問題 / 学際研究 / 文化交流 / 文化人類学 / 自然と人間生活 / protein structure / functional site in a protein / bacteria / site-directed mutagenesis / protease inhibitor / enzyme inhibitor / protein engineering / プロテア-ゼ・インヒビタ- / 阜ロテイーゼ・インヒビター / 蛋白質の構造 / 蛋白質の機能部位 / バクテリア / 部位指定変異 / 酵素阻害剤 / 蛋白工学 / X線結晶構造解析 / DNA結合蛋白質 / 分子動力学シミュレーション / フォールディング / 蛋白質フォールディング / 構造空間探索 / 反応座標 / 蛋白質構造 / 拡張アンサンブル法 / 分子シミュレーション / 高圧 / 創薬 / 抗プリオン化合物 / プリオン病 / プリオン蛋白質 / ケト・エノール平衡 / アセチルアセトン / 高圧石英セル / 分子内回転 / リボヌクレアーゼA / ジメトキシパラシクロファン Less

Understanding of antigen recognition mechanism of multispecific antibodies
- Principal Investigator
  
  KAMATARI Yuji
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biophysics
- Research Institution
  Gifu University
Inhibition of a prion conversion by suppressing protein fluctuations using small-molecules
- Principal Investigator
  
  KAMATARI Yuji O.
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biophysics
- Research Institution
  Gifu University
A hybrid extended ensemble simulation study on the folding process of proteins
- Principal Investigator
  
  YONEZAWA Yasushige
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biophysics
- Research Institution
  Kinki University
圧力軸実験を主とするアミロイド形成と解離メカニズムの研究Principal Investigator
- Principal Investigator
  
  赤坂一之
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Science and Engineering
- Research Institution
  Kinki University
蛋白質の水和と熱励起構造Principal Investigator
- Principal Investigator
  
  赤坂一之
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Science and Engineering
- Research Institution
  Kinki University
INVESTIGATION OF THE MECHANISM OF AMYLOID FIBRIL FORMATION FROM PRESSURE EXPERIMENTSPrincipal Investigator
- Principal Investigator
  
  AKASAKA Kazuyuki
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  KINKI UNIVERSITY
New Concept on the Phase Space of the Protein : Experiments and Theory
- Principal Investigator
  
  KUWATA Kazuo
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biophysics
- Research Institution
  Gifu University
Effects of general anesthetics on molecular dynamics and conformation of neuronal receptor channel protains - Molecular mechanism of general anesthesia -
- Principal Investigator
  
  MASHIMO Takashi
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Osaka University
New Development of Protein Research Based on Interatomic CavityPrincipal Investigator
- Principal Investigator
  
  GEKKO Kunihiko, 赤坂一之
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biophysics
- Research Institution
  Hiroshima University
  Kobe University
蛋白質の基本構造に対する圧力効果Principal Investigator
- Principal Investigator
  
  赤坂一之
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Kobe University
High Pressure NMR Study on the Control of Organic Chemical Reaction by Pressure.
- Principal Investigator
  
  YAMADA Hiroaki
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Organic chemistry
- Research Institution
  Kobe University
蛋白質立体構造安定性に及ぼす圧力効果Principal Investigator
- Principal Investigator
  
  赤坂一之
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kobe University
Joint research on structural fluctuations in proteins-Studied by hydrogen isotope exchange and high pressure NMRPrincipal Investigator
- Principal Investigator
  
  AKASAKA Kazuyuki
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Field
  
  Biophysics
- Research Institution
  Kobe University
NMR Analysis of Pressure-Induced Structural Changes in PrioteinsPrincipal Investigator
- Principal Investigator
  
  AKASAKA Kazuyuki
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biophysics
- Research Institution
  KOBE UNIVERSITY
蛋白質変性に対する圧力効果Principal Investigator
- Principal Investigator
  
  赤坂一之
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kobe University
高圧力の印加による有機反応の加速と制御の基礎的研究
- Principal Investigator
  
  山田博昭
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Organic chemistry
- Research Institution
  Kobe University
Structures and Formation Mechanisms of Folding Intermediates of Proteins
- Principal Investigator
  
  KATAOKA Mikio
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for Co-operative Research (A)
- Research Field
  
  Biophysics
- Research Institution
  Osaka University
DEVELOPMENT OF A PRESSURE-JUMP NMR APPARATUSPrincipal Investigator
- Principal Investigator
  
  AKASAKA Kazuyuki
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Physical chemistry
- Research Institution
  DEPARTMENT OF CHEMISTRY,FACULTY OF SCIENCE,KOBE UNIVERSITY
温度ジャンプNMRによるヘムタンパク質の構造形成過程Principal Investigator
- Principal Investigator
  
  赤坂一之
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kobe University
JAPAN-ITALY PROGRAM ON FRONTIER FIELDS -NATURE AND HUMAN LIFE-
- Principal Investigator
  
  IMANISHI Yukio
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Kyoto University
STUDIES ON NON-NATIVE STRUCTURES OF PROTEINSPrincipal Investigator
- Principal Investigator
  
  AKASAKA Kazuyuki
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  Biophysics
- Research Institution
  DEPARTMENT OF CHEMISTRY,FACULTY OF SCIENCE,KOBE UNIVERSITY
温度ジャンプNMRによるヘムタンパク質多元構造のダイナミックスPrincipal Investigator
- Principal Investigator
  
  赤坂一之
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kobe University
温度ジャンプNMRを用いた金属タンパク質の多元的構造と反応過程制御の研究Principal Investigator
- Principal Investigator
  
  赤坂一之
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
Japan-Italy Program on Frontier Fields Nature and Human Life
- Principal Investigator
  
  IMANISHI Yukio
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Kyoto University
Determination of structure and dynamics of liquid crystalline molecules by state-correlated 2D NMR spectroscopy
- Principal Investigator
  
  NAITO Akira
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  物理化学一般
- Research Institution
  HIMEJI INSTITUTE OF TECHNOLOGY
高速温度ジャンプNMR装置の開発とそのタンパク質構造転移への応用Principal Investigator
- Principal Investigator
  
  赤坂一之
- Project Period (FY)
  1990 – 1992
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  生物物性学
- Research Institution
  Kobe University
  Kyoto University
Research on the structure required for function of protease inhibitor proteins produced by bacteria by protein engineering
- Principal Investigator
  
  MIURA Kin-ichiro
- Project Period (FY)
  1990 – 1992
- Research Category
  
  Grant-in-Aid for Co-operative Research (A)
- Research Field
  
  広領域
- Research Institution
  GAKUSHUIN UNIVERSITY, FACULTY OF SCIENCE(INSTITUTE FOR BIOMOLECULAR SCIENCE)
  The University of Tokyo
Effect of Molecular Structure on Radiation-Induced Processes in Condensed Phase
- Principal Investigator
  
  SHIDA Tadamasa
- Project Period (FY)
  1988 – 1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  物理化学一般
- Research Institution
  KYOTO UNIVERSITY
recAタンパク質の動的構造と機能Principal Investigator
- Principal Investigator
  
  赤坂一之
- Project Period (FY)
  1987
- Research Category
  
  Grant-in-Aid for Special Project Research
- Research Institution
  Kyoto University
Multi-disciplinary Studies with Protein Engineering Approaches on Proteinaceous Proteinase Inhibitors of Microbial Origin
- Principal Investigator
  
  HIROMI Keitaro
- Project Period (FY)
  1987 – 1989
- Research Category
  
  Grant-in-Aid for Co-operative Research (A)
- Research Field
  
  広領域
- Research Institution
  Kyoto University
核酸-蛋白質相互作用のX線,NMRによる研究
- Principal Investigator
  
  田中勲
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for Special Project Research
- Research Institution
  Nagoya University
reCAタンパク質の動的構造と機能Principal Investigator
- Principal Investigator
  
  赤坂一之
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for Special Project Research
- Research Institution
  Kyoto University
相転移を利用した二次元NMR分光法の開発Principal Investigator
- Principal Investigator
  
  赤坂一之
- Project Period (FY)
  1986 – 1988
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research
- Research Field
  
  構造化学
- Research Institution
  Kyoto University
Quantitative analysis of internal motions in proteins.Principal Investigator
- Principal Investigator
  
  AKASAKA Kazuyuki
- Project Period (FY)
  1986 – 1987
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  生物物性学
- Research Institution
  Kyoto University
Dynamic Analysis of Enzyme Functions
- Principal Investigator
  
  HIROMI Keitaro
- Project Period (FY)
  1985 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  応用生物化学・栄養化学
- Research Institution
  Kyoto University

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All Journal Article Presentation Book

[Book] 「第13章　揺らぐ蛋白質構造を捉える-高圧NMR」（CSJカレントレビュー　第17号『極限環境の生命科学』）2014
- Author(s)
  赤坂一之, 前野覚大
- Publisher
  化学同人
- Data Source
  KAKENHI-PROJECT-24570180
[Book] 第2節タンパク質（進化する食品高圧加工技術～基礎から最新の応用事例まで～）2013
- Author(s)
  赤坂一之・前野覚大
- Total Pages
  314
- Publisher
  エヌ・ティー・エス社
- Data Source
  KAKENHI-PROJECT-24570180
[Book] 「9章　高圧力NMR」（寺島正秀編：揺らぎ・ダイナミクスと生体機能）2013
- Author(s)
  北原　亮、赤坂一之
- Total Pages
  368
- Publisher
  化学同人
- Data Source
  KAKENHI-PROJECT-24570180
[Book] Protein Folding Protocols in Methods in Molecular Biology Vol.350 (edited by Yawen Bai and Ruth Nussinov) (Humana Press Inc.)2006
- Author(s)
  赤坂一之 (M.Lassalle)
- Publisher
  The Use of High pressure NMR to Study in Protein Folding
- Data Source
  KAKENHI-PROJECT-18031040
[Journal Article] Application of high pressure NMR in the study of protein structure and dynamics2016
- Author(s)
  H. Li，Y. O. Kamatari，R. Kitahara，K. Akasaka
- Journal Title
  
  Chinese Journal of Magnetic Resonance
  
  Volume: 33 Pages: 1-26
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07024
[Journal Article] Structural fluctuation of proteins induced by thermodynamic perturbation2015
- Author(s)
  Fumio Hirata, Kazuyuki Akasaka
- Journal Title
  
  J. Chem. Phys.
  
  Volume: 142 Issue: 4
- DOI
  10.1063/1.4906071
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24570180
[Journal Article] Cavity as a source of conformational fluctuation and high-energy state: High-pressure NMR study of a cavity-enlarged mutant of T4 lysozyme2015
- Author(s)
  Maeno A, Sindhikara D, Hirata F, Otten R, Dahlquist FW, Yokoyama S, Akasaka K, Mulder FA, Kitahara R.
- Journal Title
  
  Biophys. J.
  
  Volume: 108 Issue: 1 Pages: 133-145
- DOI
  10.1016/j.bpj.2014.11.012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24570180, KAKENHI-PROJECT-25840025
[Journal Article] Pressure and Protein Dynamism2014
- Author(s)
  K. Akasaka
- Journal Title
  
  High Pressure Research
  
  Volume: 34
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24570180
[Journal Article] Pressure-assisted dissociation and degradation of "proteinase K-resistant" fibrils prepared by seeding with scrapie-infected hamster prion protein.2014
- Author(s)
  Akasaka K, Maeno A, Murayama T, Tachibana H, Fujita Y, Yamanaka H, Nishida N, Atarashi R.
- Journal Title
  
  Prion
  
  Volume: 8(4) Issue: 4 Pages: 314-318
- DOI
  10.4161/pri.32081
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23300127, KAKENHI-PROJECT-24570180, KAKENHI-PROJECT-25450444, KAKENHI-PROJECT-25640029
[Journal Article] Tyrosine/tyrosinate fluorescence at 700MPa: A pressure unfolding study of chicken ovomucoid at pH122013
- Author(s)
  Maeno A, Matsuo H, Akasaka K.
- Journal Title
  
  Biophys Chem.
  
  Volume: 183 Pages: 57-63
- DOI
  10.1016/j.bpc.2013.07.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24570180
[Journal Article] 高圧NMR で探る蛋白質のダイナミズム2013
- Author(s)
  赤坂一之
- Journal Title
  
  高圧力の科学と技術
  
  Volume: 23 Pages: 3-12
- NAID
  10031156142
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24570180
[Journal Article] 高圧NMRで探る蛋白質のダイナミズム2013
- Author(s)
  赤坂一之
- Journal Title
  
  高圧力の科学と技術
  
  Volume: 23 Pages: 3-13
- NAID
  10031156142
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24570180
[Journal Article] Exploring the folding energy landscape with pressure2013
- Author(s)
  K. Akasaka, R. Kitahara, Y. O. Kamatari
- Journal Title
  
  Arch. biochem. biophys
  
  Volume: 531 Issue: 1-2 Pages: 110-115
- DOI
  10.1016/j.abb.2012.11.016
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24570180, KAKENHI-PUBLICLY-23107729
[Journal Article] Pressure-induced chemical shifts as probes for conformational fluctuations in proteins2013
- Author(s)
  Kitahara R, Hata K, Li H, Williamson MP, Akasaka K.
- Journal Title
  
  Prog Nucl Magn Reson Spectrosc.
  
  Volume: 71 Pages: 35-58
- DOI
  10.1016/j.pnmrs.2012.12.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24570180, KAKENHI-PROJECT-25840025, KAKENHI-PUBLICLY-23107729
[Journal Article] 高圧蛋白質NMR2012
- Author(s)
  赤坂一之
- Journal Title
  
  NMR (Bulletin of the Nuclear Magnetic Resonance Society of Japan)
  
  Volume: 3 Pages: 38-45
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24570180
[Journal Article] Direct evidence of generation and accumulation of β-sheet-rich prion protein in ScN2a cells de novo illuminated by human IgG1 antibody recognizing β-form but not α-form of prion protein2012
- Author(s)
  Toshiya Kubota, Yuta Hamazoe, Shuhei Hashiguchi, Daisuke Ishibashi, Kazuyuki Akasaka, Noriyuki Nishida, Shigeru Katamine, Suehiro Sakaguchi, Ryota Kuroki, Toshihiro Nakashima, Kazuhisa Sugimura.
- Journal Title
  
  The Journal of biological chemistry
  
  Volume: 287巻 Issue: 17 Pages: 14023-14039
- DOI
  10.1074/jbc.m111.318352
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790435, KAKENHI-PROJECT-24570180, KAKENHI-PROJECT-24591482
[Journal Article] Novel aspects of protein conformational fluctuations revealed by variable pressure NMR2007
- Author(s)
  Kazuyuki Akasaka
- Journal Title
  
  High Pressure Bioscience and Biotechnology Proceedings of the 4th International Conference on High Pressure Bioscience and Biotechnology 1
  
  Pages: 8-12
- NAID
  130004951208
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18031040
[Journal Article] Pressure dissociation kinetics of amyloid protofibrils.2007
- Author(s)
  赤坂一之, 橘秀樹 (Abdul Raziq Abdul Latif)
- Journal Title
  
  Biophysical Journal 94
  
  Pages: 323-329
- Data Source
  KAKENHI-PROJECT-18031040
[Journal Article] Amyloid protofibril is highly voluminous and compressible.2007
- Author(s)
  Kazuyuki Akasaka
- Journal Title
  
  Biochemistry 46
  
  Pages: 10444-10450
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18031040
[Journal Article] Conformational fluctuations of proteins revealed by variable pressure NMR.2006
- Author(s)
  Hua, L., Akasaka, K.
- Journal Title
  
  Biochim.Biophys.Acta (Special issue) (In press)
- Data Source
  KAKENHI-PROJECT-16041244
[Journal Article] Probing Conformational Fluctuation of Proteins by Pressure Perturbation.2006
- Author(s)
  赤坂一之 (K.Akasaka)
- Journal Title
  
  Chemical Reviews Thematic Issue "Protein Dynamics and Folding" (Guest Editor : A. Joshua Wand) 108
  
  Pages: 1814-1835
- Data Source
  KAKENHI-PROJECT-18031040
[Journal Article] Conformational fluctuations of proteins revealed by variable pressure NMR.2006
- Author(s)
  Hua, L., Akasaka, K.
- Journal Title
  
  Biochim.Biophys.Acta (Special issue) (in press)
- Data Source
  KAKENHI-PROJECT-16370054
[Journal Article] The use of high pressure NMR to study protein folding.2006
- Author(s)
  Lassalle, M.W., Akasaka, K.
- Journal Title
  
  Method in Molecular Biology (in press)
- Data Source
  KAKENHI-PROJECT-16370054
[Journal Article] Probing Conformational Fluctuation of Proteins by Pressure Perturbation2006
- Author(s)
  K.Akasaka
- Journal Title
  
  Chemical Reviews Thematic Issue "Protein Dynamics and Folding" (印刷中)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16370054
[Journal Article] Conformational fluctuations of proteins revealed by variable pressure NMR.2006
- Author(s)
  赤坂一之 (H. Li)
- Journal Title
  
  Biochimica et Biophysica Acta 1764
  
  Pages: 331-345
- Data Source
  KAKENHI-PROJECT-18031040
[Journal Article] 可変圧力NMR法による新しい蛋白質構造パラダイムの構築。2006
- Author(s)
  北原亮, 横山茂之, 赤坂一之
- Journal Title
  
  分光研究 55・1
  
  Pages: 10-20
- NAID
  10016735137
- Data Source
  KAKENHI-PROJECT-16370054
[Journal Article] Cold denaturation of ubiquitin at high pressure2006
- Author(s)
  Kitahara R., Okuno, A., Kato, M., Taniguchi Y., Yokoyama, S., Akasaka, K.
- Journal Title
  
  Magnetic Resonance in Chemistry. (In press)
- Data Source
  KAKENHI-PROJECT-16041244
[Journal Article] Probing Conformational Fluctuation of Proteins by Pressure Perturbation2006
- Author(s)
  K.Akasaka
- Journal Title
  
  Chemical Reviews Thematic Issue "Protein Dynamics and Folding" (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16370054
[Journal Article] 可変圧力NMR法による新しい蛋白質構造パラダイムの構築2006
- Author(s)
  北原亮, 横山茂之, 赤坂一之
- Journal Title
  
  分光研究 55・1
  
  Pages: 10-20
- NAID
  10016735137
- Data Source
  KAKENHI-PROJECT-16041244
[Journal Article] NMR snapshots of a fluctuating protein structure. Ubiquitin at 30 bar - 3kbar2005
- Author(s)
  Ryo Kitahara, Shigeyuki Yokoyama Kazuyuki Akasaka
- Journal Title
  
  Journal of Molecular Biology 347
  
  Pages: 277-285
- Data Source
  KAKENHI-PROJECT-16041244
[Journal Article] Pressure-jump NMR study of dissociation and association of amyloid protofibrils.2005
- Author(s)
  Kamatari, Y.O., Yokoyama, S., Tachibana, H., Akasaka, K.
- Journal Title
  
  Journal of Molecular Biology 349
  
  Pages: 916-921
- Data Source
  KAKENHI-PROJECT-16370054
[Journal Article] Pressure jump NMR study of dissociation and association of amyloid protofibrils.2005
- Author(s)
  Kamatari, Y.O., Yokoyama, S., Tachibana, H., Akasaka, K
- Journal Title
  
  Journal of Molecular Biology 349
  
  Pages: 916-921
- Data Source
  KAKENHI-PROJECT-16041244
[Journal Article] Slow conformational dynamics in the Hamster prion protein.2004
- Author(s)
  Kazuo Kuwata, Yuji O.Kamatari, Kazuyuki Akasaka, Thomas L.James
- Journal Title
  
  Biochemistry 43
  
  Pages: 4439-4446
- Data Source
  KAKENHI-PROJECT-16370054
[Journal Article] Infrequent cavity-forming fluctuations in HPr from Staphylococcus carnosus revealed by pressure and temperature-dependent tyrosine ring-flips.2004
- Author(s)
  Mineyuki Hattori, Hua Li, Hiroaki Yamada, Kazuyuki Akasaka
- Journal Title
  
  Protein Science 13
  
  Pages: 3104-3114
- Data Source
  KAKENHI-PROJECT-16041244
[Journal Article] Pressure-dissociable reversible assembly of naturally denatured lysozyme is a precursor for amyloid fibrils.2004
- Author(s)
  Tara N.Niraula, Takashi Konno, Hua Li, Hiroaki Yamada, Kazuyuki Akasaka, Hideki Tachibana
- Journal Title
  
  Proc.Natl.Acad.Sci.USA 101
  
  Pages: 4089-4093
- Data Source
  KAKENHI-PROJECT-16370054
[Journal Article] 可変圧力NMRが明かす蛋白質の新しい概念2004
- Author(s)
  赤坂一之
- Journal Title
  
  高圧力の科学と技術 13
  
  Pages: 328-334
- Data Source
  KAKENHI-PROJECT-16370054
[Journal Article] High pressure NMR spectroscopy for characterizing non-native conformers of proteins2004
- Author(s)
  Y.O.Kamatari, R.Kitahara, H.Yamada, S.Yokoyama, K.Akasaka
- Journal Title
  
  Methods 34
  
  Pages: 133-143
- Data Source
  KAKENHI-PROJECT-16370054
[Journal Article] High-Pressure NMR offers the new view of the protein structure.2002
- Author(s)
  Kazuyuki Akasaka
- Journal Title
  
  Seibutu Buturi 42(5)
  
  Pages: 206-211
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14380314
[Journal Article] 解説新しいタンパク質構造の世界をひらく高圧NMR2002
- Author(s)
  赤坂一之
- Journal Title
  
  生物物理 42
  
  Pages: 206-211
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14380314
[Presentation] タンパク質機能発現におけるキャビティの重要性2014
- Author(s)
  鎌足雄司, 赤坂一之, 李華
- Organizer
  第14回日本蛋白質科学会年会
- Place of Presentation
  横浜
- Year and Date
  2014-06-27
- Data Source
  KAKENHI-PROJECT-24570180
[Presentation] “非生物的揺らぎ”から“生物的揺らぎ”へ：そのからくりを問う。シンポジウム：生物ダイナミズムの源泉を問う―“非生物的揺らぎ”が生み出す“生物的揺らぎ”2013
- Author(s)
  赤坂一之
- Organizer
  第51回日本生物物理学会年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-24570180
[Presentation] 分子動力学法を用いた高圧下におけるc-Myb タンパク質とキャビティ内水分子の変動解析2013
- Author(s)
  曽我部拓哉, 吉田久, 赤坂一之
- Organizer
  第13回日本蛋白質科学会年会
- Place of Presentation
  鳥取
- Data Source
  KAKENHI-PROJECT-24570180
[Presentation] Revealing protein dynamics with high-pressure NMR2013
- Author(s)
  Kazuyuki Akasaka
- Organizer
  European High Pressure Research Group International Meeting (EHPRG51)
- Place of Presentation
  London, UK
- Invited
- Data Source
  KAKENHI-PROJECT-24570180
[Presentation] タンパク質の揺らぎの源としてのキャビティと水和2013
- Author(s)
  鎌足雄司, 李華, 赤坂一之
- Organizer
  第18回生物関連高圧研究会シンポジウム
- Place of Presentation
  岐阜
- Data Source
  KAKENHI-PROJECT-24570180
[Presentation] システインの添加が高圧下フィシン処理鶏卵白アレルゲンの分解性の向上とアレルゲン性の低減に及ぼす影響2013
- Author(s)
  蛭田あゆみ, 原崇, 赤坂一之, 西海理之
- Organizer
  第18回生物関連高圧研究会シンポジウム
- Place of Presentation
  岐阜
- Data Source
  KAKENHI-PROJECT-24570180
[Presentation] Pressure and the Protein World2008
- Author(s)
  Kazuyuki Akasaka
- Organizer
  Proteins Under Pressure
- Place of Presentation
  Santa Fe, USA
- Data Source
  KAKENHI-PROJECT-18031040

1. YAMADA Hiroaki (90030767)

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AKASAKA Kazuyuki 赤坂 一之

Research Projects

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圧力軸実験を主とするアミロイド形成と解離メカニズムの研究Principal Investigator

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蛋白質の水和と熱励起構造Principal Investigator

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INVESTIGATION OF THE MECHANISM OF AMYLOID FIBRIL FORMATION FROM PRESSURE EXPERIMENTSPrincipal Investigator

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New Development of Protein Research Based on Interatomic CavityPrincipal Investigator

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蛋白質の基本構造に対する圧力効果Principal Investigator

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蛋白質立体構造安定性に及ぼす圧力効果Principal Investigator

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Joint research on structural fluctuations in proteins-Studied by hydrogen isotope exchange and high pressure NMRPrincipal Investigator

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NMR Analysis of Pressure-Induced Structural Changes in PrioteinsPrincipal Investigator

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AKASAKA Kazuyuki 赤坂一之