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HIGUTI Tomihiko  樋口 富彦

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… Alternative Names

HIGUCHI Tomihiko  樋口 富彦

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Researcher Number 50035557
Other IDs
External Links
Affiliation (based on the past Project Information) *help 2007 – 2008: The University of Tokushima, Institute of Health Biosciences, Graduate School, professor
2007: 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 准教授
2006: 徳島大学, 大学院ヘルスバイオサイエンス研究部, 教授
2004 – 2005: The University of Tokushima, Graduate School Institute of Health Biosciences, Professor, 大学院・ヘルスバイオサイエンス研究部, 教授
1999 – 2003: 徳島大学, 薬学部, 教授 … More
1994 – 1997: 徳島大学, 薬学部, 教授
1987 – 1993: 徳島大学, 薬学部, 助教授
1988: 徳島大学, 楽学部, 助教授
1986: Pharmaceutical Sciences, Tokushima Univ. Associate Professor, 薬学部, 助教授 Less
Review Section/Research Field
Principal Investigator
Functional biochemistry / 代謝生物化学 / Science and Engineering / 広領域 / 物質生物化学 / Functional biochemistry
Except Principal Investigator
Morphological basic dentistry / Metabolomics / General internal medicine (including Psychosomatic medicine) / Biological Sciences
Keywords
Principal Investigator
ミトコンドリア / ATP合成酵素 / MRSA / バイオジェネシス / subunit b / エネルギー変換 / チャージリン / JVS / フラボン / flavone … More / ATP synthase / ミトコンドリアDNA / URFA6L / 生体エネルギー / ディスプレイ / ディファレンシャル / 細胞 / HeLa / 蛍光蛋白質 / 形態形成 / Mitochondrial DNA / Chargerin / 構造活性相関 / vraR & vraS / xanthatin / gallic acid / β-ラクタム剤-感受性誘導薬 / 生薬 / mitochondria / biogenesis / Mitochondria / 異方性阻害剤 / 選択毒性 / Differential Display / JVSマウス / 遺伝子発現制御 / 転写調節 / トランス作働性因子 / シス-要素 / 遺伝子 / 細胞内情報伝達系 / 制癌剤 / Molecular cloning / Proton pump / Energy transduction / 遺伝子操作 / サブユニットb / プロトンポンプ / チャ-ジリン / エネルギ-変換 / Energy Transduction / Bioenergetics / 進化 / chargerin / two-components signal transduction system / structure-activity relationship / alkyl gallate / high throughput screening / intensifier of β-lactam-susceptibility / medicinal plants / ストレスに対する抵抗性 / 好気的エネルギー産生 / SAR解析 / ハイ・スループット・スクリーニング / β-ラクタム剤-感受性増強薬 / 生薬植物 / 親水性基と疎水性基 / 最適炭素鎖長 / 岩白菜 / 二成分系シグナルトランスダクション / アルキルガレート / ハイスループット・スクリーニング / β-ラクタム剤-感受性増強効果 / 薬用植物 / cytochrome / time-laps deconvolution / fusogen / mitochondrial reticulum / carnitin / JVS mouse / H^+-ATP合成酵素 / シトクロム / フュソジェン / 網状ミトコンドリア / カルニチン / inducers of β-lactam-susceptibility in MRSA (ILSMR) / systemic infection in mice / two component signal transduction / differential hybridization / drug resistance / mecA / β-ラクタム剤耐性遺伝子 / 耐性遺伝子 / 転写制禦系 / PBP2' / mecA mRNA / two-component signal transduction system / vraS / vraR / b-ラクタム剤-感受性誘導薬 / MRSA感染マウス / two-comonentsignal transduction / Differential Hybridization / 薬剤耐性 / falvone / beta-lactam-sensitizers / beta-lactam antibiotics / antimicrobial agents / crude drugs / highly resistant MRSA / Xanthatin / Ethyl gallate / 蒼耳 / 訶子 / 菌体外分泌物質 / ガロイル基 / Gallic acid / Apigenin / 半枝蓮 / β-ラクタム剤 / 抗菌活性物質 / 高度耐性MRSA / tetrazlium / surface potential / H^+-pump / planner bilayr membrane / anisotropic inhibitor / chemosmotic model / bioenergetics / parallel condenser model / 活性制御 / テトラゾリウム / 電気生理 / サブユニットe / 膜電位 / リピド平面二重膜 / 化学浸透圧説 / コンデンサー仮説 / enhancer / Aging / transcriptional regulation / エンハンサー70K / エンハンサー45K / BTEB / Sp1 / subunit b遺伝子 / ヒト遺伝子 / エンハンサー / シス要素 / 老化 / Human brease cancer (MX-1) / Cisplatin / Anisotropic inhibitor / Selective toxicity / Anticancer drug / 白血病由来細胞(P388) / Sarcoma180 / 癌診断薬 / ヒト乳癌(MXー1) / シスプラチン / 一次構造 / ミトコンドリア遺伝子 / 細胞周期 / ディファレンシャルディスプレイ / HeLa細胞 / cDNAマイクロアレイ / 分子シンクロナイゼイション / カルシウム / 転写制御 / エネルギー代謝 / 抗がん剤 … More
Except Principal Investigator
vqsR / pvdS / rpoN / rpoS / gene chip / ミトコンドリア / H^+-ATP合成酵素 / ppGppc / adherent bacteria / stress response / antibiotic tolerance / Pseudomonas aeruginosa / tcp gene / 抗菌薬 / tolerance / pyoverdine / 遺伝子発現 / quorum sensing / 緑膿菌 / 付着 / ppGpp / 付着細菌 / ストレス応答 / 抗菌薬抵抗性 / fatty acid / mitochondria / OCTN-2 / carnitine / influenza / hypoglycemia / JVS mouse / インフルエンザ脳症 / インフルエンザウイルス / Gene Chip / OCTN 2 / JVS マウス / 長鎖脂肪酸 / OCTN2 / カルニチン / インフルエンザ / 低血糖症 / JVSマウス / 中国雲南省 / 伝承医薬品 / 生薬学 / 民間薬 / 伝承薬物 / 雲南省 / 伝統薬物調査 / 天然物化学 / 少数民族薬物 / 民間医療 / 伝承医薬 / 癌転移 / 血管新生阻害剤 / 血管新生 / 血管内皮細胞 / 分子組織 / バイオセンサ / バイオ素子 / 分子系超構造 / 光駆動リン酸化システム / 高分子ヘテロ構造体 / 自己組織化能 / 融合タンパク質 / カルモジュリン / リポソーム / タリン / アパタイト / リゾチーム / ナノ会合体 / 脂質修飾抗体 / 自己組織化 / ハロロドプシン光電変換デバイス / ラット肝H^+-ATP合成酵素 / 光・電子機能タンパク質 / 粘菌内リン脂質組成変動 / 分子間情報伝達材料 / ニオイセンサ- / H^+ーATP合成酵素 / 抗ピレニルアラニル抗体 / 細胞知覚 / 活性可変酵素 / インポ-トプレカ-サ / H_+ーATP合成酵素 / 光制御抗原抗体反応 / 非天然アミノ酸ポリペプチド / 細胞内カルシウム / 比蛍光面像法 / カルモジュリンハイブリッド / 導電性酵素膜 Less
  • Research Projects

    (28 results)
  • Co-Researchers

    (40 People)
  •  Second survey on the folk medicine of minority groups in Yunnan Province of China, and a study about its utilization

    • Principal Investigator
      TAKAISHI Yoshihisa
    • Project Period (FY)
      2006 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      General internal medicine (including Psychosomatic medicine)
    • Research Institution
      The University of Tokushima
  •  Molecular analysis of anteliotic-tolerance and stress response in adherent bacteria

    • Principal Investigator
      ONO Tsuneko
    • Project Period (FY)
      2005 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Morphological basic dentistry
    • Research Institution
      The University of Tokushima
  •  JVSマウスを用いたミトコンドリアのバイオジェネシスに係わる新規蛋白質因子の解析Principal Investigator

    • Principal Investigator
      樋口 富彦
    • Project Period (FY)
      2003
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Functional biochemistry
    • Research Institution
      The University of Tokushima
  •  Mechanism of encephalitis after influenza virus infection based on defect of β-oxidation in liver

    • Principal Investigator
      KUWAJIMA Masamichi
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Metabolomics
    • Research Institution
      The University of Tokushima
  •  ミトコンドリア増生の分子シンクロナイゼイションと新規蛋白質因子の解析Principal Investigator

    • Principal Investigator
      樋口 富彦
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Science and Engineering
    • Research Institution
      The University of Tokushima
  •  JVSマウスを用いたミトコンドリアのバイオジェネシスに係わる新規蛋白質因子の解析Principal Investigator

    • Principal Investigator
      樋口 富彦
    • Project Period (FY)
      2002
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Functional biochemistry
    • Research Institution
      The University of Tokushima
  •  TITLE OF PROJECT : Invention of intensifiers of antibiotics-susceptibility against multi-drugs resistant pathogenic bacteria and invesrigation for novel control system of multi-drugs resistancePrincipal Investigator

    • Principal Investigator
      HIGUTI Tomihiko
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      広領域
    • Research Institution
      The University of Tokushima
  •  血管新生をターゲットにした癌悪性化阻止戦略―血管内皮細胞膜に存在するH^+-ATP合成酵素阻害剤のスクリーニングと癌治療への応用―

    • Principal Investigator
      新垣 尚捷
    • Project Period (FY)
      2001
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokushima
  •  Novel factors in the biogenesis of mitochondrial reticulum found from heart of juvenile visceral steatosis mousePrincipal Investigator

    • Principal Investigator
      HIGUTI Tomihiko
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Functional biochemistry
    • Research Institution
      The University of Tokushima
  •  ATP合成酵素の分子構築における遺伝子制御の分子シンクロナイゼイション機構Principal Investigator

    • Principal Investigator
      樋口 富彦
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Review Section
      Science and Engineering
    • Research Institution
      The University of Tokushima
  •  Development of "induces of β-lactam-susceptibility in MRSA (ILSMR)" and elucidaton of the novel regulatory mechanismPrincipal Investigator

    • Principal Investigator
      HIGUTI Tomihiko
    • Project Period (FY)
      1999 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Functional biochemistry
    • Research Institution
      The University of Tokushima
  •  生体分子素構造の人工的組織構造化による新機能発現

    • Principal Investigator
      相澤 益男
    • Project Period (FY)
      1995 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tokyo Institute of Technology
  •  Mitochondrial H^+-ATP synthase as a Paralled CondenserPrincipal Investigator

    • Principal Investigator
      HIGUTI Tomihiko
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Institution
      Faculty of Pharmaceutical Sciences, The University of Tokushima
  •  Studies on new antimicrobial agents from crude drugs against nosocomial methicillin-resistant Staphylococcus aureusPrincipal Investigator

    • Principal Investigator
      HIGUTI Tomihiko
    • Project Period (FY)
      1995 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Functional biochemistry
    • Research Institution
      The University of Tokushima
  •  Transcriptional regulation proteins of human ATP synthae subunit b genePrincipal Investigator

    • Principal Investigator
      HIGUTI Tomihiko
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Functional biochemistry
    • Research Institution
      Faculty of Pharmaceutical Sciences, The University of Tokushima
  •  ミトコンドリアATP合成酵素-分子構築,エネルギー変換とCa制御の分子機作の解明Principal Investigator

    • Principal Investigator
      樋口 富彦
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokushima
  •  ヒトH^+-ATP合成酵素subunit b遺伝子の発現制御に係る蛋白質因子の解析Principal Investigator

    • Principal Investigator
      樋口 富彦
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Functional biochemistry
    • Research Institution
      The University of Tokushima
  •  生体情報・エネルギー変換分子材料の設計および機能制御

    • Principal Investigator
      相澤 益男
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tokyo Institute of Technology
  •  抗がん剤の効果増強の新システムの開発Principal Investigator

    • Principal Investigator
      樋口 富彦
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokushima
  •  ミトコンドリアH^+-ATP合成酵素の分子構築とエネルギー変換機作Principal Investigator

    • Principal Investigator
      樋口 富彦
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokushima
  •  ヒトH±ATP合成酵素のsubunitb遺伝子の発現制御機作Principal Investigator

    • Principal Investigator
      樋口 富彦
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      代謝生物化学
    • Research Institution
      The University of Tokushima
  •  生体情報・エネルギ-変換分子材料の設計および機能制御

    • Principal Investigator
      相澤 益男
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tokyo Institute of Technology
  •  生体情報・エネルギ-変換分子材料の設計および機能制御

    • Principal Investigator
      相澤 益男
    • Project Period (FY)
      1990
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tokyo Institute of Technology
  •  Developmental research of selective toxic anticancer drug and cancer-diagnose drug targeting cancer mitochondriaPrincipal Investigator

    • Principal Investigator
      HIGUCHI Tomihiko
    • Project Period (FY)
      1989 – 1991
    • Research Category
      Grant-in-Aid for Developmental Scientific Research
    • Research Field
      代謝生物化学
    • Research Institution
      Tokushima University
  •  チャージリンーその三次構造の解明とエネルギー変換機作の研究Principal Investigator

    • Principal Investigator
      樋口 富彦
    • Project Period (FY)
      1988 – 1989
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokushima
  •  CHARGERIN---ITS TERTIARY STRUCTURE AND THE MECHANISM OF ENERGY TRANSDUCTIONPrincipal Investigator

    • Principal Investigator
      HIGUTI Tomihiko
    • Project Period (FY)
      1988 – 1989
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      代謝生物化学
    • Research Institution
      TOKUSHIMA UNIVERSITY
  •  チャージリンーその分子構造とエネルギー変換機作の研究Principal Investigator

    • Principal Investigator
      樋口 富彦
    • Project Period (FY)
      1987
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      物質生物化学
    • Research Institution
      The University of Tokushima
  •  Chargerins which generate Negative Charges on the Outer Surface of Mitochondrial Inner MembranePrincipal Investigator

    • Principal Investigator
      HIGUTI T.
    • Project Period (FY)
      1985 – 1986
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      代謝生物化学
    • Research Institution
      Tokushima University
  • 1.  SHIBATA Hirofumi (00093865)
    # of Collaborated Projects: 9 results
    # of Collaborated Products: 0 results
  • 2.  ARAKAKI Naokatu (60151148)
    # of Collaborated Projects: 8 results
    # of Collaborated Products: 0 results
  • 3.  KUWAJIMA Masamichi (00205262)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 4.  相澤 益男 (00016742)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 5.  宍戸 昌彦 (60026268)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 6.  上田 哲男 (20113524)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 7.  SATO Yoichi
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 8.  TAKAISHI Yoshihisa (60035558)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  KAWAZOE Kazuyoshi (00248296)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  MURAKAMI Kotarou (10035553)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  KASHIWADA Yoshiki (30169429)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  TERADA Hiroshi (00035544)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  KUDO Kioshi (50144978)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  ISHIMURA Kazunori (90112185)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  SHINOHARA Yasuo (60226157)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  TSUKAGUCHI Hiroyasu (60335792)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  ONO Tsuneko (40035514)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  MIYAKE Yoichiro (80136093)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  ABIKO Yoshimitsu (70050086)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  KUWAHARA Tomomi (60263810)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  KAYAMA Shizuo (50432761)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  栗原 堅三 (00016114)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  久保 いづみ (40214986)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  北川 幸己 (60093853)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  宝谷 紘一 (80025444)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 26.  小久保 正 (30027049)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 27.  片岡 一則 (00130245)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 28.  上野 明道 (80136267)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 29.  村上 圭史 (10335804)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 30.  HAO Xiaojiang
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 31.  LI Shunlin
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 32.  XIE Lishan
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 33.  YANAGI Yoshikazu
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 34.  KRAAYENHOF Ruud
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 35.  DEVENSH R.J
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 36.  NAGLEY Phillip
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 37.  SHINGYOUCHI Ken-ichi
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 38.  SHIKISHIMA Yasuhiro
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 39.  PONNAPPA B.C
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 40.  PONNAPPA Biddanda C
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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