ISHIHARA Mariko 石原真理子

Researcher Number	50095329
Other IDs
Affiliation (based on the past Project Information) *help	2011 – 2013: 明海大学, 歯学部, 講師 2002 – 2005: 明海大学, 歯学部, 講師
Review Section/Research Field	Principal Investigator Dental engineering/Regenerative dentistry / Functional basic dentistry Except Principal Investigator 補綴理工系歯学
Keywords	Principal Investigator 細胞傷害活性 / 半経験的分子軌道法 / 口腔癌細胞 / イソキノリン / QSAR / テトラハイドロイソキノリン / 口腔扁平上皮癌 / 分子記述子 / 構造活性相関 / 分子デザイン … More / イソフラバノン誘導体 / フッ化ビタミンD_3誘導体 / ガレイン酸誘導体 / PM3法 / アポトーシス / 反応機構 / クルクミン / β-ジケトン類 / 口腔扁平上皮癌細胞 / SAR and QSAR / ハードネス理論 / ノコバクチン類 / 鉄キレート錯体 / ヒト口腔癌細胞 / 構造活性相関(QSAR) / 最安定配座 … More Except Principal Investigator bond-dissociation energy / radical species / induction period / thiol / polyphenols / monophenols / PM III calculation / antioxidant-activity / 半経験的分子規道法 / SOMO / HOMO / stoichiometric factor / ラジカル捕捉 / 過酸化ベンゾイルラジカル / ポリフェノール / フェノール / 半経験的分子軌道法 / quinone / inhibition rate constant / Stoichiometric factor / MMAラジカル重合 / アゾビスイソブチロニトリル / 過酸化ベンゾイル / t-butyl-alkyl phenol / PM 3 calculation / peroxy radical / alkyl radical / monophenol / PM3 calculation / antioxidant Less

Study of relationship between the structure of dental materials and their cytotoxicity by semiempirical molecular-orbital method and designing of new cytotoxic materials against OSCCPrincipal Investigator
- Principal Investigator
  
  ISHIHARA Mariko
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dental engineering/Regenerative dentistry
- Research Institution
  Meikai University
半経験的分子軌道法を用いた分子構造とアポトーシス誘導活性の相関関係の体系化Principal Investigator
- Principal Investigator
  
  石原真理子
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Functional basic dentistry
- Research Institution
  Meikai University
Kinetic study of radical scavenging activity of phenolic antioxidants
- Principal Investigator
  
  FUJISAWA Seiichiro
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  補綴理工系歯学
- Research Institution
  Meikai University

All 2014 2013 2012 2011 2005 2004 Other

All Journal Article Presentation Book

[Book] ポリフェノール : 薬用植物および食品の機能性成分第8章, ポリフェノール類の抗酸化活性の予測2012
- Author(s)
  石原真理子, 他
- Publisher
  シーエムシー出版
- Data Source
  KAKENHI-PROJECT-23592898
[Book] ポリフェノール：薬用植物および食品の機能性成分　　　　　　　　　　第8章ポリフェノール類の抗酸化活性予測2012
- Author(s)
  石原真理子
- Total Pages
  277
- Publisher
  （株）シーエムシー出版
- Data Source
  KAKENHI-PROJECT-23592898
[Book] New Food Industry 53 (10)2011
- Author(s)
  坂上宏，　石原真理子，　齋藤潤，　東風幹子，　東風睦之
- Publisher
  New Food Industry
- Data Source
  KAKENHI-PROJECT-23592898
[Journal Article] Quantitative Structure-Activity Relationship Analysis of Cytotoxicity and Anti-UV Activity of 2-Aminotropones2014
- Author(s)
  Sekine s., Shimodaira C., Uesawa Y., Kagaya N., Kanda Y., Ishihara M., 他
- Journal Title
  
  Anticancer Res
  
  Volume: 34巻 Pages: 1743-1750
- NAID
  120005520960
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592898
[Journal Article] Quantitative Structure-Activity Relationship Analysis of Cytotoxicity and Anti-UV Activity of 2-Aminotropones2014
- Author(s)
  SEKINE S.,SHIMODAIRA C., UESAWA Y., KAGAYA H., KANDA Y., ISHIHARA M., AMANO O., SAKAGAMI H., WAKABAYASHI H.
- Journal Title
  
  Anticancer Res
  
  Volume: 34
- NAID
  120005520960
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592898
[Journal Article] QSAR Analyses of Cytotoxiciy and Tumor-specificity of Licorice Flavonoids by Semi-empirical Methods2013
- Author(s)
  Ohno H., Uesawa Y., Kagaya H., Ishihara M., Sakagami H., Yamamoto M.
- Journal Title
  
  Anticancer Res
  
  Volume: 33巻 Pages: 3061-3068
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592898
[Journal Article] QQSAR Analyses of Cytotoxiciy and Tumor-specificity of Licorice Flavonoids by Semi-empirical Methods2013
- Author(s)
  OHNO　H., UESAWA　Y., KAGAYA 　H., ISHIHARA M., SAKAGAM H., YAMAMOTO M.
- Journal Title
  
  Anticancer Res
  
  Volume: 33 Pages: 3061-3068
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592898
[Journal Article] Quantitative structure-activity relationship analysis for2012
- Author(s)
  Yoshihiro Uesawa, Masami Kawase, Mariko Ishihara, Hiroshi Sakagami,
- Journal Title
  
  International Journal of Molecular Medicine, 30(Supplement1), S51
  
  Volume: 30(Supplement1), S51 Pages: 4231-4238
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592898
[Journal Article] "Quantitative Structure-Activity Relationship(QSAR) Analysis of Tumor-specificity of 1,2,3,4-Tetrahydroisoquinoline Derivatives2011
- Author(s)
  Uesawa,Y., Mohri,K., Kawase,M., Ishihara, M., Sakagami, H.
- Journal Title
  
  ANTICANCER RESEARCH
  
  Volume: 31 Pages: 4231-4238
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592898
[Journal Article] Re-evalution of Cytotoxicity and Iron Chelation Activity of Therr β-Diketones by Semiempirical Molecular Orbital Method.2005
- Author(s)
  Ishihara M.
- Journal Title
  
  In vivo 19(1)
  
  Pages: 119-124
- Data Source
  KAKENHI-PROJECT-15659444
[Journal Article] Quantitative structure-cytotoxicity relationship analysis of betulinic acid and its deriveatives by semi-empirical molecular-orbital method2005
- Author(s)
  Ishihara M.
- Journal Title
  
  Anticanser Res. 25(3)
  
  Pages: 3951-3956
- Data Source
  KAKENHI-PROJECT-15659444
[Journal Article] Kinetic radical scavenging activity and cytotoxicity of 2-methoxy-and 2-t-butyl-substituted phenols and their dimers.2004
- Author(s)
  Fujisawa S, Atsumi T, Kadoma Y, Ishihara M, Ito S, Yokoe I
- Journal Title
  
  Anticancer Res 24
  
  Pages: 3019-3026
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14571859
[Journal Article] Comparativeradicalproductionandcytotoxicityinducedbycamphorquinone and 9-fluorenoneagainsthumanpulpfibroblast2004
- Author(s)
  AtsumiT, IshiharaM, KadomaY, TonosakiK, FujisawaS
- Journal Title
  
  J Oral Rehab 31
  
  Pages: 1115-1164
- Data Source
  KAKENHI-PROJECT-14571859
[Journal Article] Cytotoxicity, ROS-generation activityandradical-scavengingactivityofcurcuminandrelatedcompounds2004
- Author(s)
  FujisawaS, AtsumiT, Ishiharam, KadomaY
- Journal Title
  
  AnticancerRes 24
  
  Pages: 563-570
- Data Source
  KAKENHI-PROJECT-14571859
[Journal Article] Dipalmitoylphosphatidylcholine (DPPC) andDPPC/Cholesterolliposomesa spredictorsofthecytotoxicityofbis-GMArelatedcompounds2004
- Author(s)
  FujisawaS, Atsumit, KadomaY, Ishihara M, YokoeI
- Journal Title
  
  JliposomeRes 14・1
  
  Pages: 39-49
- Data Source
  KAKENHI-PROJECT-14571859
[Journal Article] Kineticradicalscavengingactivityandcytotoxicityof2-methoxy-and2- substitutedt-butylphenolsandtheirdimers2004
- Author(s)
  FujisawaS, AtsumiT, KadomaY, Ishiharam, ItoS, YokoeI
- Journal Title
  
  AnticancerRes 24
  
  Pages: 3019-3026
- Data Source
  KAKENHI-PROJECT-14571859
[Journal Article] Kinetics of the radical scavenging activity of eta-carotene-related compounds2004
- Author(s)
  Fujisawa S, Ishihara M, kadoma Y
- Journal Title
  
  QSAR, SAR. Environ Res 15
  
  Pages: 33-41
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571859
[Journal Article] Cytotoxicity, ROS-generation and radical-scavengingactivity Ofcurcuminabdrelated compounds2004
- Author(s)
  Fujisawa S, Atsumi T, Ishihara M, kadoma Y
- Journal Title
  
  Anticancer Res 24
  
  Pages: 563-570
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571859
[Journal Article] Re-evaluation of cytotoxicity and iron chelation activity of three β-diketones by semiemoirical molecular orbital method.2004
- Author(s)
  MARIKO ISHIHARA
- Journal Title
  
  In vivo 18(In press)
- Data Source
  KAKENHI-PROJECT-15659444
[Journal Article] Kinetic radical scavenging activity and cytotoxicity of 2-methoxy-and2-t-butyl-substituted Phenolsandtheirdimers2004
- Author(s)
  Fujisawa S, Atsumi T, Kadoma Y, Ishihara M, Ito S, Yokoe I
- Journal Title
  
  Anticancer Res 24
  
  Pages: 3019-3026
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571859
[Journal Article] Cytotoxicity, ROS-generationactivity and radical-scavenging activity of curcumin and related compounds2004
- Author(s)
  Fujisawa S, Atsumi T, Ishihara M, Kadoma Y
- Journal Title
  
  Anticancer Res 24
  
  Pages: 563-570
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14571859
[Presentation] Designing of new cytotoxic isoquinolines against human oral squamous cell carcinoma cell lines (Part 3)2014
- Author(s)
  石原真理子
- Organizer
  第87回日本薬理学会年会
- Place of Presentation
  仙台国際センター
- Data Source
  KAKENHI-PROJECT-23592898
[Presentation] Designing of new cytotoxic isoquinolines against human OSCC cell lines（Part３）2014
- Author(s)
  石原　真理子
- Organizer
  第８７回日本薬理学会年会
- Place of Presentation
  仙台国際センター
- Data Source
  KAKENHI-PROJECT-23592898
[Presentation] Designing of new cytotoxic isoquinolines against human OSCC cell lines2013
- Author(s)
  Ishihara M., Sakagami H.
- Organizer
  2nd Meeting of the International Association for Dental Research- Asia Pacific Region
- Place of Presentation
  Plaza Athenee
- Data Source
  KAKENHI-PROJECT-23592898
[Presentation] Designing of new cytotoxic isoquinolines against human OSCC cell lines2013
- Author(s)
  Ishihara M., Sakagami H.
- Organizer
  2nd Meeting of the International Association for Dental Research- Asia Pacific Region
- Place of Presentation
  Bangkok
- Data Source
  KAKENHI-PROJECT-23592898
[Presentation] ヒト口腔癌細胞に傷害活性を有する新規イソキノリン誘導体類のデザイン2013
- Author(s)
  石原真理子、山内雅司
- Organizer
  第６５回歯科基礎医学会学術大会
- Place of Presentation
  岡山コンベンションセンター
- Data Source
  KAKENHI-PROJECT-23592898
[Presentation] Changes of metabolic profiles in oral squamous cell carcinoma2013
- Author(s)
  Sakagamih., Ishihara M., Shoji T., Tanaka Y., Murakami ., Sugimoto M.
- Organizer
  2nd Meeting of the International Association for Dental Research- Asia Pacific Region
- Place of Presentation
  Plaza Athenee
- Data Source
  KAKENHI-PROJECT-23592898
[Presentation] QSAR analyses of cytotoxiciy and tumor-specificity of licorice flavonoids by semi-emprical methods2013
- Author(s)
  植沢芳広、石原真理子、　坂上宏、　加賀谷肇、　大野裕和、　山本正次
- Organizer
  第８６回　日本薬理学会年会
- Place of Presentation
  福岡国際会議場
- Data Source
  KAKENHI-PROJECT-23592898
[Presentation] Designing of new cytotoxic isoquinolines against human oral squamous cell carcinoma cell lines (Part 2)2013
- Author(s)
  石原真理子
- Organizer
  第８６回　日本薬理学会年会
- Place of Presentation
  福岡国際会議場
- Data Source
  KAKENHI-PROJECT-23592898
[Presentation] 分子軌道法を用いた1, 2, 3, 4-テトラヒドロイソキノリン誘導体の構造-腫瘍選択性相関解析2012
- Author(s)
  石原真理子
- Organizer
  第85回日本薬理学会年会
- Place of Presentation
  京都、国立京都国際会館
- Data Source
  KAKENHI-PROJECT-23592898
[Presentation] Designing of new cytotoxic tetrahydroisoquinolines against oral squamous cell carcinoma2012
- Author(s)
  Mariko Ishihara
- Organizer
  90th General Session & Exhibition of the International Association for Dental Research (IADR)
- Place of Presentation
  ブラジル, イグアス
- Data Source
  KAKENHI-PROJECT-23592898
[Presentation] Quantitative structure-activity relationship analysis for tumor-specificity of tetrahydroisoquinoline derivatives2012
- Author(s)
  Uesawa,Y.,Kawase,M.,Ishihara,M., Sakagami H
- Organizer
  17th World Congress on Advances in Oncology and 15th International Symposium on Molecular Medicine
- Place of Presentation
  Creta Maris, Hersonissos, Crete, Greece
- Data Source
  KAKENHI-PROJECT-23592898
[Presentation] Quantitative structure-activity relationship analysis for2012
- Author(s)
  Yoshihiro Uesawa, Masami Kawase, Mariko Ishihara, Hiroshi Sakagami,
- Organizer
  17th World Congress on Advances in Oncology and
- Place of Presentation
  Creta Maris, Hersonissos, Crete, Greece
- Data Source
  KAKENHI-PROJECT-23592898
[Presentation] Designing of new cytotoxic tetrahydroisoquinolines against oral squamous cell carcinoma2012
- Author(s)
  Mariko Ishihara ,Hiroshi Sakagami
- Organizer
  90th General Session & Exhibition of the International Association for Dental Research (IADR)
- Place of Presentation
  ブラジル，イグアス
- Data Source
  KAKENHI-PROJECT-23592898
[Presentation] ヒト口腔癌細胞に傷害活性を有する新規イソキノリン誘導体類のデザイン2012
- Author(s)
  石原　真理子
- Organizer
  第54回歯科基礎医学会学術大会・総会，
- Place of Presentation
  奥羽大学
- Data Source
  KAKENHI-PROJECT-23592898
[Presentation] 分子軌道法を用いた1,2,3,4－テトラヒドロイソキノリン誘導体の構造ー腫瘍選択性相関解析
- Author(s)
  植沢芳広, 毛利公則, 河瀬雅美, 石原真理子, 坂上宏
- Organizer
  第85回日本薬理学会年会
- Place of Presentation
  京都、国立京都国際会館
- Data Source
  KAKENHI-PROJECT-23592898
[Presentation] Role of hydrogen peroxide in the cytotoxicity induction by sodium 5,6-benzylidene -L-ascorbate and benzaldehyde
- Author(s)
  石原　真理子
- Organizer
  第85回日本薬理学会年会
- Place of Presentation
  京都、国立京都国際会館
- Data Source
  KAKENHI-PROJECT-23592898
[Presentation] ヒト口腔癌細胞に傷害活性を有する新規イソキノリン誘導体類のデザイン
- Author(s)
  石原　真理子
- Organizer
  第53回歯科基礎医学会学術大会
- Place of Presentation
  岐阜、長良川国際会議場
- Data Source
  KAKENHI-PROJECT-23592898

1. FUJISAWA Seiichiro (40014162)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
2. ATSUMI Toshiko (60049385)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
3. KADOMA Yoshinori (00092403)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
4. 坂上宏 (50138484)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

ISHIHARA Mariko 石原 真理子

Research Projects

Research Products

Co-Researchers

Study of relationship between the structure of dental materials and their cytotoxicity by semiempirical molecular-orbital method and designing of new cytotoxic materials against OSCCPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

半経験的分子軌道法を用いた分子構造とアポトーシス誘導活性の相関関係の体系化Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Kinetic study of radical scavenging activity of phenolic antioxidants

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] ポリフェノール : 薬用植物および食品の機能性成分 第8章, ポリフェノール類の抗酸化活性の予測2012

Author(s)

Publisher

Data Source

[Book] ポリフェノール：薬用植物および食品の機能性成分 第8章ポリフェノール類の抗酸化活性予測2012

Author(s)

Total Pages

Publisher

Data Source

[Book] New Food Industry 53 (10)2011

Author(s)

Publisher

Data Source

[Journal Article] Quantitative Structure-Activity Relationship Analysis of Cytotoxicity and Anti-UV Activity of 2-Aminotropones2014

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Quantitative Structure-Activity Relationship Analysis of Cytotoxicity and Anti-UV Activity of 2-Aminotropones2014

Author(s)

Journal Title

NAID

Data Source

[Journal Article] QSAR Analyses of Cytotoxiciy and Tumor-specificity of Licorice Flavonoids by Semi-empirical Methods2013

Author(s)

Journal Title

Data Source

[Journal Article] QQSAR Analyses of Cytotoxiciy and Tumor-specificity of Licorice Flavonoids by Semi-empirical Methods2013

Author(s)

Journal Title

Data Source

[Journal Article] Quantitative structure-activity relationship analysis for2012

Author(s)

Journal Title

Data Source

[Journal Article] "Quantitative Structure-Activity Relationship(QSAR) Analysis of Tumor-specificity of 1,2,3,4-Tetrahydroisoquinoline Derivatives2011

Author(s)

Journal Title

Data Source

[Journal Article] Re-evalution of Cytotoxicity and Iron Chelation Activity of Therr β-Diketones by Semiempirical Molecular Orbital Method.2005

Author(s)

Journal Title

Data Source

[Journal Article] Quantitative structure-cytotoxicity relationship analysis of betulinic acid and its deriveatives by semi-empirical molecular-orbital method2005

Author(s)

Journal Title

Data Source

[Journal Article] Kinetic radical scavenging activity and cytotoxicity of 2-methoxy-and 2-t-butyl-substituted phenols and their dimers.2004

Author(s)

Journal Title

Description

Data Source

[Journal Article] Comparativeradicalproductionandcytotoxicityinducedbycamphorquinone and 9-fluorenoneagainsthumanpulpfibroblast2004

Author(s)

Journal Title

Data Source

[Journal Article] Cytotoxicity, ROS-generation activityandradical-scavengingactivityofcurcuminandrelatedcompounds2004

Author(s)

ISHIHARA Mariko 石原真理子

[Book] ポリフェノール : 薬用植物および食品の機能性成分第8章, ポリフェノール類の抗酸化活性の予測2012

[Book] ポリフェノール：薬用植物および食品の機能性成分　　　　　　　　　　第8章ポリフェノール類の抗酸化活性予測2012