SAKAGAMI Hiroshi 坂上宏

Researcher Number	50138484
Other IDs
External Links
Affiliation (Current)	2023: 明海大学, 歯学部, 教授
Affiliation (based on the past Project Information) *help	1999 – 2022: 明海大学, 歯学部, 教授 1991 – 1994: 昭和大学, 医学部, 講師 1987 – 1988: 昭和大学, 医学部, 講師 1986: 昭和大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Basic Section 57010:Oral biological science-related / Pathobiological dentistry/Dental radiology / 病態科学系歯学(含放射線系歯学) / Functional basic dentistry / 応用薬理学・医療系薬学 / Biological pharmacy / Social dentistry / Functional basic dentistry Except Principal Investigator Conservative dentistry / Food science … More / Anesthesiology/Resuscitation studies / Basic Section 57060:Surgical dentistry-related / Basic Section 57070:Developmental dentistry-related / Social dentistry / Biological pharmacy / Conservative dentistry / Anesthesiology/Resuscitation studies / Surgical dentistry / Drug development chemistry / Functional basic dentistry Less
Keywords	Principal Investigator アポトーシス / NO / Apoptosis / 口腔扁平上皮癌細胞 / 選択毒性 / クロモン誘導体 / 腫瘍選択性 / ポリフェノール / MnSOD / 細胞死 … More / ヒト口腔扁平上皮癌 / DNA断片化 / Lignin / リグニン / 構造活性相関 / 細胞死のタイプ / シグナル伝達 / 口腔扁平上皮癌 / 代謝物変化 / 遺伝子発現 / 作用点 / クロモン誘導体の標識 / 細胞への取り込み / ヒト口腔扁平上皮がん細胞 / パスウェイ解析 / キナーゼ阻害活性 / 抗炎症効果 / 副作用の緩和 / 作用機序 / 有機合成 / 3-スチリルクロモン類 / 化学記述子 / 置換基 / QSAR / オーロン / ピペリン酸エステル / スチリルクロモン / subG1 / アポトーシス誘導能 / 3次元構造 / QSAR解析 / カスパーゼ-3 / 細胞周期 / 分子軌道解析 / クロモン環 / Drug resistance / Asparagine synthetase / Macrophage / Oral carcinoma / Polyphenol / 薬物代謝酵素 / アスパラギン / 薬剤耐性 / アスパラギン合成酵素 / マクロファージ / 口腔癌 / Bax / HlF-1α / Cell death / Human squamous cell carcinoma / Antioxidant / M30モノクローナル抗体 / VEGF / 口腔癌細胞 / ボリフュノール / ビタミンC / HIF-1 / bax / HIF-1α / 抗酸化剤 / Endonuclease / Calcium / Hydrogen peroxide / Catalase / DNA fragmentation / Ascorbic acid / Benzylideneascorbate / カルシウム / エンドヌクレアーゼ / 過酸化水素 / カタラーゼ / アスコルビン酸 / ベンジリデンアスコルベート / Cytokine / Active oxygen / Mechanism / HIV / Antiviral activity / Synthesis / Phenylpropenoid / ラジカル / 不活化 / インフルエンザウイルス / 抗ウイルス剤 / 合成リグニン / フェニルプロパノイド / サイトカイン / 活性酸素 / 作用メカニズム / エイズウイルス / 抗ウイルス作用 / 合成 / フェニルプロペノイド / 代謝異常 / 老化マーカー / ハイドロキシプロリン / コラーゲン / 老化 / 炎症 / 歯肉線維芽細胞 / プロリン / グリシン / メタボローム解析 / プレニルアルコール / ビタミンK_2 / ベンズアルデヒド誘導体 / 細胞のタイプ / 環状α,β-不飽和ケトン / 細胞間での感受性の差 / β不飽和ケトン / 環状α / オートファジー … More Except Principal Investigator アポトーシス / 口腔癌 / オートファジー / VEGF / p53 / 硬組織再生 / 歯髄幹細胞 / 歯学 / 高分子ポリフェノール / ギョリュウ科 / 人工タンニン / 抗腫瘍作用 / タンニン / ポリフェノール / がん細胞 / ネクローシス / 合成リグニン / 抗菌性 / BRM / リグニン / Geranylgeraniol / クロモン誘導体 / 細胞透過性ペプチド / ハイパーサミア / マイルドハイパーサーミア / 併用療法 / 腫瘍選択性磁性体 / 低侵襲性治療 / ハイパーサーミア / 末梢 / 中枢 / 矯正歯科治療 / 痛覚 / 半導体レーザー / CO2レーザー / 動物実験 / レーザー / 疼痛抑制 / 鎮痛薬 / GFAP / グリア線維性酸性タンパク質 / サテライトグリア細胞 / 末梢性疼痛 / TRPV / 矯正治療 / TRPV1 / 疼痛 / 歯の移動 / 長寿命化 / 運動 / 老化 / メタボローム解析 / 身体機能改善 / 水中運動 / 唾液 / 老化マーカー / 象牙芽細胞 / 石灰化誘導 / シグナル伝達経路 / 象牙芽細胞への分化 / ヒト歯髄幹細胞 / シグナル伝達系 / CD44 / ヒアルロン酸 / 分化誘導 / Interleukin-6 / Tumor necrosis factor / Differentiation inducing factor / Human myelogenous leukemic cells / インターロイキンー6 / インターロイキン-6 / 腫瘍壊死因子 / マクロファージ / 分化誘導因子 / ヒト骨髄性白血病細胞 / cancer / autophagy / codeinone / morphine / morphinone / apoptosios / オピオイド / モルフィノン / チアミラール / ミダゾラム / 静脈麻酔薬 / プロポフォール / 局所麻酔薬 / モルヒネ / 癌 / endodontics / apical periodontitis / macrolides / 歯内治療 / 根尖性歯周炎 / マクロライド / Cancer / Codeinone / Morphione / Apoptosis / コデイン / アポトシス / ガン細胞 / コデイノン / モルフィネ / dendritic cell / anticancer drug / apoptosis / gene alteration / squamous cell carcinoma / oral cancer / 樹状細胞 / 抗癌剤 / 遺伝子変異 / 扁平上皮癌 / 組織培養 / Feijoa sellowiana / フトモモ科 / 薬用植物 / 食用植物 / 抗腫瘍効果 / Tamarix tetrandra / Tamarix aphylla / Tamarix nilotica / 加水分解性タンニンオリゴマー / 多血小板血漿 / 幹細胞 / 歯髄 / 生体材料 / 再生医学 / 口腔がん細胞 / 物質生産 / 未利用植物資源 / ギョリュウ科植物 / 口腔がん / 培養がん細胞 / 機能性成分 / 植物 / 食品 / バラ科 / 植物組織培養 / 機能性食品 / アドレナリン / リドカイン / ジブカイン / シダゾラム / adrenaline / clonidine / dexmedetomidine / 癌細胞 / 蘇生学 / 麻酔 / N-アシルプロリン / ジフルオロクロロメチルケ / 細胞毒性 / テトラハイドロイソキノリ / 活性型カルボニル / N-チオアシルプロリン / Dakin-West反応 / 構造活性相関 / 抗菌活性 / ジフルオロメチルケトン / クロロジフルオロメチルケト / ピロール / トリフルオロメチル / クオラムセンシング / ヒドロキシケトン / クロロジフルオロメチルケトン / トリフルオロメチルケトン / カルボニル化合物 / 化合物ライブラリー / イソフラバノン誘導体 / フッ化ビタミンD_3誘導体 / ガレイン酸誘導体 / PM3法 / 反応機構 / クルクミン / β-ジケトン類 / 口腔扁平上皮癌細胞 / SAR and QSAR / ハードネス理論 / ノコバクチン類 / 鉄キレート錯体 / ヒト口腔癌細胞 / 細胞傷害活性 / 構造活性相関(QSAR) / 最安定配座 / 半経験的分子軌道法 / 抗ウイルス性 / 免疫反応 / 日和見感染症 / マクロファ-ジ / 好中球 / 抗ウイルス活性 Less

Elucidation of selective cytotoxicity against malignant cells by chromone derivativesPrincipal Investigator
- Principal Investigator
  
  坂上宏
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57010:Oral biological science-related
- Research Institution
  Meikai University
Development of minimally invasive therapy for oral cancer by hyperthermia with tumor-specific targeting magnetic nanoparticles
- Principal Investigator
  
  藤内祝
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Meikai University
Peripheral and central intervention to pain during orthodontic tooth movement
- Principal Investigator
  
  SUDA Naoto
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57070:Developmental dentistry-related
- Research Institution
  Meikai University
Improvement of physical function by water exercise and its effect on salivary aging markers
- Principal Investigator
  
  TAMURA NOBUAKI
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Social dentistry
- Research Institution
  Meikai University
Basic study of the possibility of newly synthesized 3-styrylchromone derivatives as therapeutic drugs for oral cancerPrincipal Investigator
- Principal Investigator
  
  Sakagami Hiroshi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathobiological dentistry/Dental radiology
- Research Institution
  Meikai University
Analysis of PI3-kinase/Akt signaling on the osteogenesis of dental pulp stem cells in human.
- Principal Investigator
  
  KATAYAMA Tadashi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Conservative dentistry
- Research Institution
  Meikai University
Polyphenols with higher molecular weights as antitumor substances in botanical foods and crude drugs
- Principal Investigator
  
  Hatano Tsutomu
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Food science
- Research Institution
  Okayama University
Development of salivary aging marker that reflects the collagen metabolitesPrincipal Investigator
- Principal Investigator
  
  SAKAGAMI Hiroshi
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Social dentistry
- Research Institution
  Meikai University
Attempts to identify the hard tissue regeneration by human dental pulp stem cells
- Principal Investigator
  
  KATAYAMA Tadashi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Conservative dentistry
- Research Institution
  Meikai University
Polyphenols of functional foods as materialseffectiveon tumor cells
- Principal Investigator
  
  HATANO Tsutomu
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Food science
- Research Institution
  Okayama University
Autophagy-inducing activity of anesthetics against various malignant cells
- Principal Investigator
  
  NAGASAKA Hiroshi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Meikai University
Small molecular library of alpha-fluorinated and -hydroxylated carbonyl compounds synthesized by newly developed reactions
- Principal Investigator
  
  KAWASE Masami
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Matsuyama University
Basic research for the development of autophagy-inducing therapy against human oral squamous cell carcinoma cell linesPrincipal Investigator
- Principal Investigator
  
  SAKAGAMI Hiroshi
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Meikai University
Induction of apoptosis by anesthetics I n the human cancer cell lines
- Principal Investigator
  
  NAGASAKA Hiroshi
- Project Period (FY)
  2004 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Meikai University
半経験的分子軌道法を用いた分子構造とアポトーシス誘導活性の相関関係の体系化
- Principal Investigator
  
  石原真理子
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Functional basic dentistry
- Research Institution
  Meikai University
Study of clinical implication and application of polyphenols in the dentistryPrincipal Investigator
- Principal Investigator
  
  SAKAGAMI Hiroshi
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  病態科学系歯学(含放射線系歯学)
- Research Institution
  Meikai University School of Dentistry
Inhibitory Effects of Antimicrobial Agent Macrolides on LPS-induced periodontal destruction in periapical region.
- Principal Investigator
  
  KIKUCHI Hirotaka
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Conservative dentistry
- Research Institution
  Meikai University
The basic and clinical study on the effective individual oral cancer therapy
- Principal Investigator
  
  SAKASHITA Hideaki
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Surgical dentistry
- Research Institution
  Meikai University
Induction of apoptosis by anesthetics in the human cancer cell lines.
- Principal Investigator
  
  NAGASAKA Hiroshi
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Meikai University
Fluctuation of HIF-1α during the cell death process of human oral squamous cell carcinoma induced by antioxidantsPrincipal Investigator
- Principal Investigator
  
  SAKAGAMI Hiroshi
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Meikai University
Benzylideneascorbate as an new antitumor agent - its mechanism of action -Principal Investigator
- Principal Investigator
  
  SAKAGAMI Hiroshi
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Showa University
制癌性BRMの新しいリード化合物を求めて一天然リグニンと関連ポリフェノール
- Principal Investigator
  
  川添豊
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Nagoya City University
制癌性BRMの新しいリ-ド化合物を求めてー天然リグニンと関連ポリフェノ-ル
- Principal Investigator
  
  川添豊
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Nagoya City University
Mechanism of antiviral action induced by newly synthesized lignins which have anti-human immunodeficiency virus activityPrincipal Investigator
- Principal Investigator
  
  SAKAGAMI Hiroshi
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Showa University
Studies on differentiation inducing factors for human myelogenous leukemic cells and enhancement of their activity.
- Principal Investigator
  
  TAKEDA Ken
- Project Period (FY)
  1986 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Showa University

[Book] NanoBioMaterials in Dentistry (ed., Prof. Alexandru Mihai Grumezescu)2015
- Author(s)
  Garcia-Contreras　R, Scougall-Vilchis RJ, Contreras-Bulnes R, Sugimoto M, NakajimaH and Sakagami H
- Total Pages
  49
- Publisher
  Elsevier
- Data Source
  KAKENHI-PROJECT-25670897
[Book] オーラルヘルスケア機能性食品の開発と応用－アンチエイジングを目指した口腔ケアを中心に－2013
- Author(s)
  坂上　宏
- Total Pages
  243
- Publisher
  シーエムシー出版
- Data Source
  KAKENHI-PROJECT-25670897
[Book] 検査診断学への展望―臨床検査指針：測定とデータ判読のポイントー2013
- Author(s)
  坂上宏、田中庄二、杉本昌弘
- Total Pages
  4
- Publisher
  南江堂
- Data Source
  KAKENHI-PROJECT-25670897
[Book] A Compendium of Essays on Alternative Therapy (edited by Bhattacharya A) (Chapter 13, Functional Analysis of Natural Polyphenols and Saponins as Alternative Medicines)2012
- Author(s)
  Sakagami H, Kushida T, Makino T, Hatano T, Shirataki Y, Matsuta T, Matsuo Y, Mimaki Y, In Tech (Rijeka, Croatia)
- Data Source
  KAKENHI-PROJECT-22580128
[Book] A Compendium of Essays on Alternative Therapy (edited by Arup Bhattacharya). Chapter 13. Functional analysis of natural polyphenols and saponins as alternative medicines (pp.269-302)2012
- Author(s)
  Sakagami H, Kushida T, Makino T, Hatano T, Shirataki Y, Matsuta T, Matsuo Y, Mimaki Y
- Publisher
  InTech (Rijeka, Croatia)
- Data Source
  KAKENHI-PROJECT-22580128
[Book] Top Heterocycl Chem 16(ed., Noboru Motohash, Quantitative Structure-Cytotoxicity Relationship of bioactive heterocycles by semi-empirical molecular orbital method with concept of absolute hardness)2009
- Author(s)
  Ishihara M, Sakagami H, Kawase M, Motohashi N
- Publisher
  Springer-Verlag
- Data Source
  KAKENHI-PROJECT-19592156
[Book] Top Heterocycl Chem 16(ed., Noboru Motohash, The chemistry of bioactive mesoionic heterocycles)2009
- Author(s)
  Kawase M, Sakagami H, Motohashi N
- Publisher
  Springer-Verlag
- Data Source
  KAKENHI-PROJECT-19592156
[Book] Quantitative Structure-Cytotoxicity Relationship of bioactive heterocycles by semi-empirical molecular orbital method with concept of absolute hardness.Top Heterocycl Chem Vol 16 pp 93-133,(ed., Noboru Motohashi)2009
- Author(s)
  Ishihara M, Sakagami H, Kawase M, Motohashi N
- Total Pages
  41
- Publisher
  Springer-Verlag Berlin Heiderberg
- Data Source
  KAKENHI-PROJECT-19592156
[Book] Tumor-specificity and type of cell death induced by heterocycles. Topics in Heter ocyolic Chemistry (ed., Noboru Motohash)2008
- Author(s)
  Sakagami Hら(7名)
- Total Pages
  26
- Publisher
  Springer-Verlag Berlin Heidelberg
- Data Source
  KAKENHI-PROJECT-19592156
[Book] Top Heterocycl Chem 15(ed., Noboru Motohash, Functionality of Anthocyanins as Alterative Medicine)2008
- Author(s)
  Motohashi N, Sakagami H
- Publisher
  Springer-Verlag
- Data Source
  KAKENHI-PROJECT-19592156
[Book] Structure-cytotoxicity relationship of selected dietary phenols and the related compounds in tumor cells2005
- Author(s)
  Kawase M, Motohashi N, Sakagami H
- Publisher
  Functional Polyphenols with Antioxidative Action REFLASH, India(In press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370607
[Book] Functional Polyphenols with Antioxidative Action, a review book series of "Chem. Pharmaceutical Sciences (CPS),ed.,Motohashi"("REFLASH",India) (ed)2005
- Author(s)
  Sakagami H, Chowdhury SA, Suzuki F et al.
- Publisher
  (In press)
- Data Source
  KAKENHI-PROJECT-14370607
[Book] Antitumor potential of polyphenols : possible application to oral cancer therapy.2005
- Author(s)
  Sakagami H, Hatano H, Takekawa H et al.
- Publisher
  Functional Polyphenols with Antioxidative Action REFLASH, India(IN press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370607
[Book] Tumor-specific cytotoxic activity of polyphenols, terpenoids, ketones and other synthetic compounds.]2005
- Author(s)
  Sakagami H, Chowdhury SA et al.
- Publisher
  Functional Polyphenols with Antioxidative Action REFLASH, India(In press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370607
[Book] Functional Polyphenols with Antioxidative Action, a review book series of "Chem. Pharmaceutical Sciences (CPS),ed.,Motohashi"("REFLASH", India) (ed)2005
- Author(s)
  Sakagami H, Hatano H, Takekawa H, et al.
- Publisher
  (In press)
- Data Source
  KAKENHI-PROJECT-14370607
[Book] Functional Polyphenols with Antioxidative Action, a review book series of "Chem. Pharmaceutical Sciences (CPS),ed.,Motohashi"("REFLASH", India) (ed)2005
- Author(s)
  Kawase M, Motohashi N, Sakagami H
- Publisher
  (In press)
- Data Source
  KAKENHI-PROJECT-14370607
[Book] Functional Polyphenols and Carotenes with Antioxidative Action2005
- Author(s)
  Sakagami H.
- Total Pages
  176
- Publisher
  Research Signpost37/661 (2), Fort P.O., Trivandrum-695 023, Keraia, India
- Data Source
  KAKENHI-PROJECT-15659444
[Book] Topics in Heterocyclic Chemistry, Springer of Germany 15(ed., Noboru Motohash, Theoretical studies on phenothiazines, benzo[a]phenothiazines, and benz[c]acridines)
- Author(s)
  Kurihara T, Shinohara K, Inabe M, Wakabayashi H, Motohashi N, Sakagami H, Molnar J
- Publisher
  Springer-Verlag
- Data Source
  KAKENHI-PROJECT-19592156
[Journal Article] A Dual Anti-Inflammatory and Anti-Proliferative 3-Styryl-chromone Derivative Synergistically Enhances the Anti-Cancer Effects of DNA-Damaging Agents on Colon Cancer Cells by Targeting HMGB1-RAGE-ERK1/2 Signaling2022
- Author(s)
  Tanuma Sei-ichi、Oyama Takahiro、Okazawa Miwa、Yamazaki Hiroaki、Takao Koichi、Sugita Yoshiaki、Amano Shigeru、Abe Takehiko、Sakagami Hiroshi
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 7 Pages: 3426-3426
- DOI
  10.3390/ijms23073426
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K09885
[Journal Article] 1-[4-(2-Dimethylaminoethoxy)phenylcarbonyl]-3,5-Bis(3,4,5-Trimethoxybenzylidene)-4-Piperidone hydrochloride and Related Compounds: Potent Cytotoxins Demonstrating Greater Toxicity to Neoplasms Than Non-Malignant Cells2022
- Author(s)
  Roayapalley Praveen Kumar、Dimmock Jonathan R.、Sakagami Hiroshi、Okudaira Noriyki、Sharma Rajendra K.、Das Umashankar
- Journal Title
  
  Medicinal Chemistry
  
  Volume: 18 Issue: 9 Pages: 1001-1012
- DOI
  10.2174/1573406418666220322154110
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K09885
[Journal Article] Tumor-Specificity, Neurotoxicity, and Possible Involvement of the Nuclear Receptor Response Pathway of 4,6,8-Trimethyl Azulene Amide Derivatives2022
- Author(s)
  Naitoh Kotone、Orihara Yuta、Sakagami Hiroshi、Miura Takumi、Satoh Keitaro、Amano Shigeru、Bandow Kenjiro、Iijima Yosuke、Kurosaki Kota、Uesawa Yoshihiro、Hashimoto Masashi、Wakabayashi Hidetsugu
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 5 Pages: 2601-2601
- DOI
  10.3390/ijms23052601
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K09885
[Journal Article] Inhibition of Neurotoxicity/Anticancer Activity of Bortezomib by Caffeic Acid and Chlorogenic Acid2022
- Author(s)
  MATSUDA REONA、SAKAGAMI HIROSHI、AMANO SHIGERU、IIJIMA YOSUKE、SANO MOTOHIKO、UESAWA YOSHIHIRO、TAMURA NOBUAKI、OISHI YOHEI、TAKESHIMA HIROSHI
- Journal Title
  
  Anticancer Research
  
  Volume: 42 Issue: 2 Pages: 781-790
- DOI
  10.21873/anticanres.15536
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K09885
[Journal Article] Comprehensive study on potent and selective carbonic anhydrase inhibitors: Synthesis, bioactivities and molecular modelling studies of 4-(3-(2-arylidenehydrazine-1-carbonyl)-5-(thiophen-2-yl)-1H-pyrazole-1-yl) benzenesulfonamides2021
- Author(s)
  Yamali Cem、Sakagami Hiroshi、Uesawa Yoshihiro、Kurosaki Kota、Satoh Keitaro、Masuda Yoshiko、Yokose Satoshi、Ece Abdulilah、Bua Silvia、Angeli Andrea、Supuran Claudiu T.、Gul Halise Inci
- Journal Title
  
  European Journal of Medicinal Chemistry
  
  Volume: 217 Pages: 113351-113351
- DOI
  10.1016/j.ejmech.2021.113351
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K09885
[Journal Article] A 3-styrylchromone converted from trimebutine 3D pharmacophore possesses dual suppressive effects on RAGE and TLR4 signaling pathways2021
- Author(s)
  Okazawa Miwa、Oyama Takahiro、Abe Hideaki、Yamazaki Hiroaki、Yoshimori Atsushi、Tsukimoto Mitsutoshi、Yoshizawa Kazumi、Takao Koichi、Sugita Yoshiaki、Kamiya Takanori、Uchiumi Fumiaki、Sakagami Hiroshi、Abe Takehiko、Tanuma Sei-ichi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 566 Pages: 1-8
- DOI
  10.1016/j.bbrc.2021.05.096
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K09885
[Journal Article] Design, Synthesis and Tumour-Selective Toxicity of Novel 1-[3-{3,5-Bis(benzylidene)-4-oxo-1-piperidino}-3-oxopropyl]-4-piperidone Oximes and Related Quaternary Ammonium Salts2021
- Author(s)
  Roayapalley Praveen K.、Dimmock Jonathan R.、Contreras Lisett、Balderrama Karol S.、Aguilera Renato J.、Sakagami Hiroshi、Amano Shigeru、Sharma Rajendra K.、Das Umashankar
- Journal Title
  
  Molecules
  
  Volume: 26 Issue: 23 Pages: 7132-7132
- DOI
  10.3390/molecules26237132
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K09885
[Journal Article] Exploring of tumor-associated carbonic anhydrase isoenzyme IX and XII inhibitory effects and cytotoxicities of the novel N-aryl-1-(4-sulfamoylphenyl)-5-(thiophen-2-yl)-1H-pyrazole-3-carboxamides2021
- Author(s)
  Yamali Cem、Inci Gul Halise、Ozli Gulsen、Angeli Andrea、Ballar Kirmizibayrak Petek、Erbaykent Tepedelen Burcu、Sakagami Hiroshi、Bua Silvia、Supuran Claudiu T.
- Journal Title
  
  Bioorganic Chemistry
  
  Volume: 115 Pages: 105194-105194
- DOI
  10.1016/j.bioorg.2021.105194
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K09885
[Journal Article] A Unique Anti-Cancer 3-Styrylchromone Suppresses Inflammatory Response via HMGB1-RAGE Signaling2021
- Author(s)
  Abe Hideaki、Okazawa Miwa、Oyama Takahiro、Yamazaki Hiroaki、Yoshimori Atsushi、Kamiya Takanori、Tsukimoto Mitsutoshi、Takao Koichi、Sugita Yoshiaki、Sakagami Hiroshi、Abe Takehiko、Tanuma Sei-ichi
- Journal Title
  
  Medicines
  
  Volume: 8 Issue: 4 Pages: 17-17
- DOI
  10.3390/medicines8040017
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09885, KAKENHI-PROJECT-18H02685
[Journal Article] Two new C-glycosidic ellagitannins and accompanying tannins from Lawsonia inermis leaves and their cytotoxic effects2021
- Author(s)
  Orabi Mohamed A.A.、Sakagami Hiroshi、Umemura Naoki、Alyami Hamad S.、Hatano Tsutomu
- Journal Title
  
  Fitoterapia
  
  Volume: 153 Pages: 104925-104925
- DOI
  10.1016/j.fitote.2021.104925
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K09885
[Journal Article] Cytotoxic Tumour-Selective 1,5-Diaryl-3-Oxo-1,4-Pentadienes Mounted on a Piperidine Ring2021
- Author(s)
  Roayapalley Praveen K.、Sakagami Hiroshi、Satoh Keitaro、Amano Shigeru、Bandow Kenjiro、Aguilera Renato J.、Hernandez Karla G. Cano、Schiaffino Bustamante Austre Y.、Dimmock Stephen G.、Sharma Rajendra K.、Das Umashankar、Dimmock Jonathan R.
- Journal Title
  
  Medicines
  
  Volume: 8 Issue: 12 Pages: 78-78
- DOI
  10.3390/medicines8120078
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K09885
[Journal Article] Quantification of the Ability of Natural Products to Prevent Herpes Virus Infection2020
- Author(s)
  Fukuchi Kunihiko、Sakagami Hiroshi、Sugita Yoshiaki、Takao Koichi、Asai Daisuke、Terakubo Shigemi、Takemura Hiromu、Ohno Hirokazu、Horiuchi Misaki、Suguro Madoka、Fujisawa Tomohiro、Toeda Kazuki、Oizumi Hiroshi、Yasui Toshikazu、Oizumi Takaaki
- Journal Title
  
  Medicines
  
  Volume: 7 Issue: 10 Pages: 64-64
- DOI
  10.3390/medicines7100064
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09885, KAKENHI-PROJECT-20K12657, KAKENHI-PROJECT-17K08254
[Journal Article] 腫瘍選択性が高く、副作用が低い新規クロモン誘導体の開発2020
- Author(s)
  坂上宏、杉田義昭、高尾浩一、永井純子、植沢芳広、飯島洋介、佐野元彦
- Journal Title
  
  New Food Industry
  
  Volume: 62 (12) Pages: 871-881
- NAID
  40022428470
- Data Source
  KAKENHI-PROJECT-20K09885
[Journal Article] Development of Newly Synthesized Chromone Derivatives with High Tumor Specificity against Human Oral Squamous Cell Carcinoma2020
- Author(s)
  Sugita Yoshiaki、Takao Koichi、Uesawa Yoshihiro、Nagai Junko、Iijima Yosuke、Sano Motohiko、Sakagami Hiroshi
- Journal Title
  
  Medicines
  
  Volume: 7 Issue: 9 Pages: 50-50
- DOI
  10.3390/medicines7090050
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09885
[Journal Article] QSAR Prediction Model to Search for Compounds with Selective Cytotoxicity Against Oral Cell Cancer2019
- Author(s)
  Nagai Junko、Imamura Mai、Sakagami Hiroshi、Uesawa Yoshihiro
- Journal Title
  
  Medicines
  
  Volume: 6 Issue: 2 Pages: 45-45
- DOI
  10.3390/medicines6020045
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11519
[Journal Article] Quantitative Structure-Cytotoxicity Relationship of 2-(N-cyclicamino)chromone Derivatives2018
- Author(s)
  SHI HAIXIA、NAGAI JUNKO、SAKATSUME TSUKASA、BANDOW KENJIRO、OKUDAIRA NORIYUKI、SAKAGAMI HIROSHI、TOMOMURA MINEKO、TOMOMURA AKITO、UESAWA YOSHIHIRO、TAKAO KOICHI、SUGITA YOSHIAKI
- Journal Title
  
  Anticancer Research
  
  Volume: 38 Issue: 7 Pages: 3897-3906
- DOI
  10.21873/anticanres.12674
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11487, KAKENHI-PROJECT-16K11519
[Journal Article] Change in Anticancer Drug Sensitivity During Neuronal Differentiation of PC12 Cells2018
- Author(s)
  SAKAGAMI HIROSHI、HARA YAEKO、SHI HAIXIA、IWAMA SOICHI、NAKAGAWA MIKA、SUZUKI HAYATO、TANAKA KENTA、ABE TOMOYUKI、TAMURA NOBUAKI、TAKESHIMA HIROSHI、HORIE NORIO、KANEKO TAKAHIRO、SHIRATSUCHI HIROSHI、KANEKO TADAYOSHI
- Journal Title
  
  In Vivo
  
  Volume: 32 Issue: 4 Pages: 765-770
- DOI
  10.21873/invivo.11306
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K12055
[Journal Article] Quantitative Structure-Cytotoxicity Relationship of Furo[2,3-b]chromones2018
- Author(s)
  Uesawa Y, Sakagami H, Shi H, Hirose M, Takao K, Sugita Y
- Journal Title
  
  Anticancer Res
  
  Volume: 38(6) Issue: 6 Pages: 3283-3290
- DOI
  10.21873/anticanres.12593
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11519
[Journal Article] Partial Protection of Paclitaxel-induced Neurotoxicity by Antioxidants2018
- Author(s)
  HARA YAEKO、SAKAGAMI HIROSHI、SHI HAIXIA、ABE TOMOYUKI、TAMURA NOBUAKI、TAKESHIMA HIROSHI、HORIE NORIO、KANEKO TAKAHIRO、SHIRATSUCHI HIROSHI、KANEKO TADAYOSHI
- Journal Title
  
  In Vivo
  
  Volume: 32 Issue: 4 Pages: 745-752
- DOI
  10.21873/invivo.11303
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K12055
[Journal Article] Quantitative Structure-Cytotoxicity Relationship of Pyrano[4,3-b]chromones2018
- Author(s)
  NAGAI JUNKO、SHI HAIXIA、KUBOTA YUKA、BANDOW KENJIRO、OKUDAIRA NORIYUKI、UESAWA YOSHIHIRO、SAKAGAMI HIROSHI、TOMOMURA MINEKO、TOMOMURA AKITO、TAKAO KOICHI、SUGITA YOSHIAKI
- Journal Title
  
  Anticancer Research
  
  Volume: 38 Issue: 8 Pages: 4449-4457
- DOI
  10.21873/anticanres.12747
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11487, KAKENHI-PROJECT-16K11519
[Journal Article] Dental Application of Natural Products2018
- Author(s)
  Sakagami Hiroshi、Tomomura Mineko
- Journal Title
  
  Medicines
  
  Volume: 5 Issue: 1 Pages: 21-21
- DOI
  10.3390/medicines5010021
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K11487, KAKENHI-PROJECT-16K11519
[Journal Article] Protection of differentiating neuronal cells from amyloid β peptide-induced injury by alkaline extract of leaves of Sasa senanensis Rehder.2018
- Author(s)
  Sakagami H, Tsuji M,Tomomura M, Masuda Y, Iwama S, Nakagawa M, Suzuki H, Tanaka K, Abe T,Tamura N, Tomomura A, Yokose S, Takeshima H, Natori T,Horiuchi M, Fujisawa T, Kiuchi Y, Oguchi K, Yasui Y, Oizumi H and Oizumi T.
- Journal Title
  
  In Vivo
  
  Volume: 32 Issue: 2 Pages: 231-239
- DOI
  10.21873/invivo.11229
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K11487, KAKENHI-PROJECT-17K12055
[Journal Article] :Quantitative structure-cytotoxicity relationship of 2-azolylchromones2018
- Author(s)
  Sakagami H, Okudaira N, Uesawa Y, Takao K, Kagaya H, Sugita Y
- Journal Title
  
  Anticancer Research
  
  Volume: 38 Issue: 2 Pages: 763-770
- DOI
  10.21873/anticanres.12282
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K11519, KAKENHI-PROJECT-15K08111
[Journal Article] Recent Progress of Basic Studies of Natural Products and Their Dental Application.2018
- Author(s)
  Sakagami H, Watanabe T, Hoshino T, Suda N, Mori K, Yasui T, Yamauchi N, Kashiwagi H, Gomi T, Oizumi T, Nagai J, Uesawa Y, Takao K, Sugita Y.
- Journal Title
  
  Medicines (Basel)
  
  Volume: 6 Issue: 1 Pages: 4-4
- DOI
  10.3390/medicines6010004
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09843, KAKENHI-PROJECT-16K11519
[Journal Article] Quantitative structure-cytotoxicity relationship of cinnamic acid phenetyl esters2018
- Author(s)
  Uesawa Y, Sakagami H, Okudaira N, Toda K, Takao K, Kagaya H and Sugita Y
- Journal Title
  
  Anticancer Research
  
  Volume: 38 Issue: 2 Pages: 817-823
- DOI
  10.21873/anticanres.12289
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K11519, KAKENHI-PROJECT-15K08111
[Journal Article] ササヘルスによるホルメシスおよび神経細胞保護効果の誘導2018
- Author(s)
  坂上　宏、友村美根子、友村明人、増田宜子、横瀬敏志、岩間聡一、中川美香、鈴木隼人、田中健大、阿部智之、大石洋平、田村暢章、竹島　浩、安井利一、辻まゆみ木内祐二、小口勝司、堀内美咲、藤澤知弘、勝呂まどか、大泉浩史、大泉高明
- Journal Title
  
  New Food Industry
  
  Volume: 60(4) Pages: 39-48
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K12055
[Journal Article] Quantitative Structure-Cytotoxicity Relationship of 3-(N-Cyclicamino)chromone Derivatives2018
- Author(s)
  SHI HAIXIA、NAGAI JUNKO、SAKATSUME TSUKASA、BANDOW KENJIRO、OKUDAIRA NORIYUKI、UESAWA YOSHIHIRO、SAKAGAMI HIROSHI、TOMOMURA MINEKO、TOMOMURA AKITO、TAKAO KOICHI、SUGITA YOSHIAKI
- Journal Title
  
  Anticancer Research
  
  Volume: 38 Issue: 8 Pages: 4459-4467
- DOI
  10.21873/anticanres.12748
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11487, KAKENHI-PROJECT-16K11519
[Journal Article] Quantitative Structure-Cytotoxicity Relationship of Aurones2017
- Author(s)
  Uesawa Y, Sakagami H, Ikezoe N, Takao K, Kagaya H and Sugita Y
- Journal Title
  
  Anticancer Research
  
  Volume: 37 Issue: 11 Pages: 6169-6176
- DOI
  10.21873/anticanres.12066
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K11519, KAKENHI-PROJECT-15K08111
[Journal Article] Quantitative structure-cytotoxicity relationship of newly synthesized piperic acid esters.2017
- Author(s)
  Sakagami H, Uesawa Y, Masuda Y, Tomomura M, Yokose S, Miyashiro T, Murai J, Takao K, Kanamoto T, Terakubo S, Kagaya H, Nakashima H, and Sugita Y.
- Journal Title
  
  Anticancer Res
  
  Volume: 37 Issue: 11 Pages: 6161-6168
- DOI
  10.21873/anticanres.12065
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K11487, KAKENHI-PROJECT-16K11519, KAKENHI-PROJECT-15K01319, KAKENHI-PROJECT-15K08111
[Journal Article] Re-evaluation of Culture Condition of PC12 and SH-SY5Y Cells Based on Growth Rate and Amino Acid Consumption2017
- Author(s)
  HIROSHI SAKAGAMI, RYUICHIRO SUZUKI, YOSHIAKI SHIRATAKI, SOICHI IWAMA, MIKA NAKAGAWA, HAYATO SUZUKI, KENTA TANAKA, NOBUAKI TAMURA, and HIROSHI TAKESHIMA
- Journal Title
  
  in vivo
  
  Volume: 31 Issue: 6 Pages: 1089-1095
- DOI
  10.21873/invivo.11174
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K12055
[Journal Article] Search for new type of anticancer drugs with high tumor-specificity and less keratinocyte toxicity (Review)2017
- Author(s)
  Sugita Y, Takao K, Uesawa Y and Sakagami H
- Journal Title
  
  Anticancer Research
  
  Volume: 37 Issue: 11 Pages: 5919-5924
- DOI
  10.21873/anticanres.12038
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K11519, KAKENHI-PROJECT-15K08111
[Journal Article] Quantitative Structure-Cytotoxicity Relationship of Chalcones2017
- Author(s)
  Sakagami H, Masuda Y,Tomomura M,Yokose S, Uesawa Y,Ikezoe N, Asahara D, Takao K, Kanamoto T, Terakubo S, Kagaya H, Nakashima H,and Sugita T.
- Journal Title
  
  Anticancer Res
  
  Volume: 37 Issue: 3 Pages: 1091-1098
- DOI
  10.21873/anticanres.11421
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11487, KAKENHI-PROJECT-16K11519
[Journal Article] Induction of Apoptosis in human oral keratinocyte by doxorubicin.2017
- Author(s)
  Sakagami H, Okudaira N, Masuda Y, Amano O, Yokose S, Kanda Y, Suguro M, Natori T, Oizumi H and Oizumi T
- Journal Title
  
  Anticancer Research
  
  Volume: 37 Issue: 3 Pages: 1023-1029
- DOI
  10.21873/anticanres.11412
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11519
[Journal Article] Hyaluronan induces odontoblastic differentiation of dental pulp stem cells via CD442016
- Author(s)
  Naoki Umemura, Emika Ohkoshi, Masamichi Tajima, Hirotaka Kikuchi, Tadashi Katayama and Hiroshi Sakagami
- Journal Title
  
  Stem Cell Research & Therapy
  
  Volume: 7 Issue: 1 Pages: 135-147
- DOI
  10.1186/s13287-016-0399-8
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462854, KAKENHI-PROJECT-26462892, KAKENHI-PROJECT-26861748
[Journal Article] Hydrolyzable tannins of tamaricaceous plants. 7 Structures and cytotoxic properties of oligomeric ellagitannins from leaves of Tamarix nilotica and cultured tissues of Tamarix tetrandra2016
- Author(s)
  Orabi MA, Taniguchi S, Sakagami H, Yoshimura M, Amakura Y, Hatano T
- Journal Title
  
  Journal of Natural Products
  
  Volume: 79 Issue: 4 Pages: 984-995
- DOI
  10.1021/acs.jnatprod.5b01065
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25450170
[Journal Article] Quantitative structure-cytotoxicity relationship of 3-benzylidenechromanones2016
- Author(s)
  Uesawa Y, Sakagami H, Kagaya H, Yamashita M, Takao K, Sugita Y
- Journal Title
  
  Anticancer Res
  
  Volume: 36 Issue: 11 Pages: 5803-5812
- DOI
  10.21873/anticanres.11164
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08111, KAKENHI-PROJECT-16K11519
[Journal Article] Alteration of metabolomic profiles by titanium dioxide nanoparticles in human gingivitis model2015
- Author(s)
  Garcia-Contreras1 R, Susigmoto M, Umemura N, Kaneko M, Hatakeyama Y, Soga T, Tomita M, Scougall-Vilchis RJ, Contreras-Bulnes R, Nakajima H and Sakagami H
- Journal Title
  
  Biomaterials
  
  Volume: 57 Pages: 3340-3340
- DOI
  10.1016/j.biomaterials.2015.03.059
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25670897, KAKENHI-PROJECT-26462860
[Journal Article] CD44 expression in human head and neck squamous cell carcinoma (HNSCC)is stimulated by baicalin, a common constituent of traditional herbal (Kampo)medicines classified as Bupleurum root drugs, and its aglycone baicalein2014
- Author(s)
  Emika Ohkoshi, Naoki Umemura, Tadashi Katayama, Hiroshi Sakagami
- Journal Title
  
  Food and Chemical Toxicology
  
  Volume: (in press)
- Data Source
  KAKENHI-PROJECT-23592806
[Journal Article] 網羅的メタボローム解析を用いた口腔扁平上皮癌細胞死誘導における代謝動態の解析2014
- Author(s)
  坂上　宏、杉本昌弘
- Journal Title
  
  口腔組織培養学会誌
  
  Volume: 23 Pages: 917-917
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25670897
[Journal Article] Metabolomic profiling of sodium fluoride-induced cytotoxicity in an oral squamous cell carcinoma cell line2014
- Author(s)
  Sakagami, H., Sugimoto, M., Tanaka, S., Onuma, H., Ota, S., Kaneko, M., Soga, T., Tomita, M.
- Journal Title
  
  Metabolomics
  
  Volume: 10 Issue: 2 Pages: 270-279
- DOI
  10.1007/s11306-013-0576-z
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22134007, KAKENHI-PROJECT-24593164, KAKENHI-PROJECT-25670897
[Journal Article] 3,5-bis{4-[4-(2-Aminoethoxy)phenylcarbo nyloxy]benzylidene}-1-methyl-4-piperido nes : A novel class of tumour-selective cytotoxins2014
- Author(s)
  Alaa Baryyan, Umashankar Das, Hiroshi Sakagami, Tadashi Katayama, Jan Balzarini, Erik De Clercq, Masami Kawase Joseph Molnár, Rajendra K. Sharma, and Jonathan R.Dimmock
- Journal Title
  
  J Enzyme Inhib Med Chem
  
  Volume: (in press)
- Data Source
  KAKENHI-PROJECT-23592806
[Journal Article] Effects of TiO2 nanoparticles on cytotoxic action of chemotherapeutic drugs against human oral squamous cell carcinoma cell lines2014
- Author(s)
  Garcia-Contreras R, Scougall-Vilchis RJ, Contreras-Bulnes R, Ando Y, Kanda Y, Hibino Y, Nakajima H and Sakagami H
- Journal Title
  
  In Vivo
  
  Volume: 28 Pages: 217-222
- Data Source
  KAKENHI-PROJECT-25670897
[Journal Article] Efficient utilization of plant resources by alkaline extraction2013
- Author(s)
  Sakagami H, Ohkoshi E, Amano S, Satoh K, Kanamoto T, Terakubo S, Nakashima H, Sunaga K, Otsuki T, Ikeda H and Fukuda T
- Journal Title
  
  Altern Integr Med
  
  Volume: 2 Issue: 07 Pages: 1-7
- DOI
  10.4172/2327-5162.1000133
- Data Source
  KAKENHI-PROJECT-25670897
[Journal Article] Induction of non-apoptotic cell death in human oral squamous cell carcinoma cell lines by Rhinacanthus nasutus extract.2012
- Author(s)
  Horii H, Suzuki R, Sakagami H, Umemura N, Ueda JY, Shirataki Y
- Journal Title
  
  In Vivo
  
  Volume: 26 Pages: 305-9
- NAID
  120005520677
- Data Source
  KAKENHI-PROJECT-21591987
[Journal Article] Quantitative structure-activity relationship(QSAR) analysis of tumor-specificity of 1, 2, 3, 4-tetrahydroisoquinoline derivatives.2011
- Author(s)
  Uesawa Y, Mohri K, Kawase M, Ishihara M, Sakagami H
- Journal Title
  
  Anticancer Res
  
  Volume: 31 Pages: 4231-4231
- Data Source
  KAKENHI-PROJECT-21591987
[Journal Article] 3,5-Bis(benzylidene)-1-[4-2-(morpholin-4-yl)ethoxyphenylcarbonyl]-4-piperidone Hydrochloride : A Lead Tumor-specific Cytotoxin Which Induces Apoptosis and Autophagy.2010
- Author(s)
  U.Das, H.Sakagami, Q.Chu, Q.Wang, M.Kawase, P.Selvakumar, R.K.Sharma, J.R.Dimmock
- Journal Title
  
  Bioorg.Med.Chem.Lett. 20
  
  Pages: 912-917
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590114
[Journal Article] Cytotoxic 2-Benzylidene-6-(nitrobenzylidene)cyclo hexanones Which Demonstrate Substantially Greater Toxicity for Neoplasms than Non-malignant Cells.2010
- Author(s)
  U.Das, A.Doroudi, H.I.Gul, H.N.Pati, M.Kawase, H.Sakagami, Q.Chu, J.P.Stables, J.R.Dimmock
- Journal Title
  
  Bioorg.Med.Chem. 18
  
  Pages: 2219-2224
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590114
[Journal Article] Cytotoxic 2-benzylidene-6-(nitrobenzylidene)cyclohex anones which display substantially greater toxicity for neoplasms than non-malignant cells.2010
- Author(s)
  Das U, Doroudi A, Gul HI, Pati HN, Kawase M, Sakagami H, Chu Q, Stables JP, Dimmock JR
- Journal Title
  
  Bioorg Med Chem 18
  
  Pages: 2219-2224
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592156
[Journal Article] Quantitative Structure-cytotoxicity Relationship of newly synthesized tropolones determined by a semiempirical molecular-orbital method (PM5)2010
- Author(s)
  Ishihara M, Wakabayashi H, Motohashi N, Sakagami H
- Journal Title
  
  Anticancer Res 30
  
  Pages: 129-133
- Data Source
  KAKENHI-PROJECT-19592156
[Journal Article] Hydrolyzable Tannins of Tamaricaceous Plants. III. Hellinoyl- and Macrocyclic-type Ellagitannins from Tamarix nilotica2010
- Author(s)
  Orabi MAA, Taniguchi S, Yoshimura M, Yoshida T, Kishino K, Sakagami H, Hatano T
- Journal Title
  
  Journal of Natural Products
  
  Volume: Vol. 73 Pages: 870-879
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22580128
[Journal Article] 3, 5-bis(Benzylidene)-1-[4-2-(morpholin-4-yl)ethoxyphenylcarbonyl]-4-pi peridone hydrochloride: A lead tumour-specific cytotoxin which induces apoptosis and autophagy.2010
- Author(s)
  Das U, Sakagami H, Chu Q, Wang Q, Kawase M, Selvakumar P, Sharma RK, Dimmock JR
- Journal Title
  
  Medicinal Chemistry Letters 20
  
  Pages: 912-917
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592156
[Journal Article] 1,3-Diaryl-2-propenones and 2-Benzylidene-1,3-indandiones : A Quest for Compounds Displaying Greater Toxicity to Neoplasms than Normal Cells.2010
- Author(s)
  H.N.Pati, U.Das, H.Sakagami, M.Kawase, Q.Chu, Q.Wang, J.P.Stables, J.R.Dimmock
- Journal Title
  
  Archiv der Pharmazie 9
  
  Pages: 535-541
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590114
[Journal Article] 1,3-Diaryl-2-propenones and 2-Benzylidene-1,3-indandiones : A Quest for Compounds Displaying Greater Toxicity to Neoplasms than Normal Cells.2010
- Author(s)
  H.N.Pati, U.Das, H.Sakagami, M.Kawase, 他4名
- Journal Title
  
  Archiv der Pharmazie
  
  Volume: 9 Pages: 535-541
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590114
[Journal Article] Hormetic response of cultured normal and tumor cells to 2-aminotropone derivatives.2010
- Author(s)
  Wakabayashi H, Narita T, Suga A, Sakagami H
- Journal Title
  
  In Vivo 24
  
  Pages: 39-44
- Data Source
  KAKENHI-PROJECT-19592156
[Journal Article] Tumor-specific cytotoxicity and type of cell death induced by benzaldehyde2010
- Author(s)
  Ariyoshi-Kishino K, Hashimoto K, Amano O, Saitoh J, Kochi M, Sakagami H
- Journal Title
  
  Anticancer Res
  
  Volume: 30 Pages: 5097-5097
- Data Source
  KAKENHI-PROJECT-21591987
[Journal Article] Sequential Cytotoxicity : A Theory Examined Using a Series of 3,5-Bis(benzylidene)-1-diethylphosphono-4-oxopiperidines and Related Phosphonic Acids.2010
- Author(s)
  S.Das, U.Das, H.Sakagami, K.Hashimoto, M.Kawase, D.K.J.Gorecki, J.R.Dimmock
- Journal Title
  
  Bioorg.Med.Chem.Lett. 20
  
  Pages: 6464-6468
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590114
[Journal Article] Amurenosides A-K, 11 new pregnane glycosides from the roots of Adonis amurensis.2010
- Author(s)
  Kuroda M, Uchida S, Sakagami H, Mimaki Y
- Journal Title
  
  Steroids 75
  
  Pages: 83-94
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592156
[Journal Article] 3,5-Bis(benzylidene)-1-[4-2(morpholin-4-yl)ethoxyphenylcarbonyl]-4-piperidone hydrochloride : a lead tumor-specific cytotoxin which induces apoptosis and autophagy2010
- Author(s)
  U.Das, H.Sakagami, Q.Chu, Q.Wang, M.Kawase, 他3名
- Journal Title
  
  Bioorg.Med.Chem.Lett. 20
  
  Pages: 912-917
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590114
[Journal Article] Estimation of relationship between the structure of trihaloacetylazulene derivatives determined by a semiempirical molecular-orbital method (PM5) and their cytotoxicity.2010
- Author(s)
  Ishihara M, Wakabayashi H, Motohashi N, Sakagami H
- Journal Title
  
  Anticancer Res 30
  
  Pages: 837-842
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592156
[Journal Article] Sequential Cytotoxicity : A Theory Examined Using a Series of 3,5-Bis(benzylidene)-1-diethylphosphono-4-oxopiperidines and Related Phosphonic Acids.2010
- Author(s)
  S.Das, U.Das, H.Sakagami, K.Hashimoto, M.Kawase, 他3名
- Journal Title
  
  Bioorg.Med.Chem.Lett.
  
  Volume: 20 Pages: 6464-6468
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590114
[Journal Article] Tumor-specific cytotoxicity and type of cell death induced by gefitinib in oral squamous cell carcinoma cell lines.2009
- Author(s)
  Chu Q, Amano O, Kanda Y, Kunii S, Wang Q, Sakagami H
- Journal Title
  
  Anticancer Res 29
  
  Pages: 5023-5031
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592156
[Journal Article] Tumor-specific cytotoxicity and type of cell death induced by naphtha[2, 3-b]furan-4, 9-diones and related compounds in human tumor cell lines: relationship to electronic structure.2009
- Author(s)
  Takano A, Hashimoto K, Ogawa M, Koyanagi J, Kurihara T, Wakabayashi H, Kikuchi H, Nakamura Y, Motohiashi N, Sakagami H, Yamamoto K, Tanaka A
- Journal Title
  
  Anticancer Res 29
  
  Pages: 455-464
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592156
[Journal Article] Estimation of relationship between structure of newly synthesized dihydroimidazoles determined by a semiempirical molecularorbital method and their cytotoxicity.2009
- Author(s)
  Takekawa F, Sakagami H, Ishihara M
- Journal Title
  
  Anticancer Res 29
  
  Pages: 5019-5022
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592156
[Journal Article] The Chemistry of Bioactive Mesoionic Heterocycles.2009
- Author(s)
  M.Kawase, H.Sakagami, N.Motohashi
- Journal Title
  
  Top.Heterocycl.Chem.(Bioactive Heteroycles VII), Splinger-Verlag 16
  
  Pages: 135-152
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590114
[Journal Article] Tumor-specific cytotoxic activity of 1, 2, 3, 4-tetrahydroisoquinoline derivatives against human oral squamous cell carcinoma cell lines2009
- Author(s)
  Hatano H, Takekawa H, Hashimoto K, Ishihara M, Kawase M, Chu Q, Wang QT, Sakagami H
- Journal Title
  
  Anticancer Res 29
  
  Pages: 3079-3086
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592156
[Journal Article] Triterpene glycosides from the tibers of Anemone coronaria.2009
- Author(s)
  Mimaki Y, Watanabe K, Matsuo Y, Sakagami H
- Journal Title
  
  Chem Pharm Bull 57
  
  Pages: 724-729
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592156
[Journal Article] Chemical constituents of the Bulbs of Habranthus brachyandrus and their cytotoxic activities.2009
- Author(s)
  Jitsuno M, Yokosuka A, Sakagami H, Mimaki Y
- Journal Title
  
  Chem Pharm Bull 57
  
  Pages: 1153-1157
- NAID
  130000124798
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592156
[Journal Article] Steroidal glycosides from Furcraea foetida and their cytotoxic activity.2009
- Author(s)
  Yokosuka A, Sano T, Hashimoto K, Sakagami H, Mimaki Y
- Journal Title
  
  Chem Pharm Bull 57
  
  Pages: 1161-1166
- NAID
  130000124800
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592156
[Journal Article] Estimation of relationship between the structure of 1,2,3,4-tetrahydroisoquinolin derivatives determined by asemiempirical molecular-orbital method and their cytotoxicity2009
- Author(s)
  Ishihara M, Hatano H, Kawase M, Sakagami H
- Journal Title
  
  Anticancer Research 29
  
  Pages: 2265-2272
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592156
[Journal Article] Estimation of relationship between descriptors and cytotoxicity of newly synthesized 1, 2, 3, 4-tetrahydroisoquinoline derivatives.2009
- Author(s)
  Ishihara M, Hatano H, Takekawa F, Kawase M, Sakagami H
- Journal Title
  
  Anticancer Res 29
  
  Pages: 4077-4082
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592156
[Journal Article] Tumor-specific cytotoxicity and type of cell death induced by benzo[b]cyclohept[e][1, 4]oxazine and 2-aminotropone derivatives.2009
- Author(s)
  Narita T, Suga A, Kobayashi M, Hashimoto K, Sakagami H, Motohashi N, Kurihara T, Wakabayashi H
- Journal Title
  
  Anticancer Res 29
  
  Pages: 1123-1130
- NAID
  120005520592
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592156
[Journal Article] Triterpene glycosides from the tibers of Anemone coronaria2009
- Author(s)
  Mimaki Y, Watanabe K, Matsuo Y, Sakagami H
- Journal Title
  
  Chem Pharm Bull 57
  
  Pages: 724-729
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592156
[Journal Article] The Chemistry of Bioactive Mesoionic Heterocycles2009
- Author(s)
  M. Kawase, H. Sakagami, N. Motohashi
- Journal Title
  
  Topics in Heterocyclic Chemistry (Bioactive Heterocycles VII) 16
  
  Pages: 135-152
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590114
[Journal Article] Triterpene glycosides from the whole plant of Anemone hupehensis var. japonica and their cytotoxic activity.2009
- Author(s)
  Yokosuka A, Sano T, Hashimoto K, Sakagami H, Mimaki Y
- Journal Title
  
  Chem Pharm Bull 57
  
  Pages: 1425-1430
- NAID
  130000124549
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592156
[Journal Article] 2-(3-Aryl-2-propenoyl)-3-methylquinoxaline-1, 4-dioxides: A novel cluster of tumor-specific cytotoxins which reverse multidrug resistance.2009
- Author(s)
  Das U, Pati HN, Panda AK, De Clercq E, Balzarini J, Molnar J, Barath Z, Ocsovszki I, Kawase M, Zhou L, Sakagami H, Dimmock JR
- Journal Title
  
  Bioorg Med Chem 17
  
  Pages: 3909-3915
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592156
[Journal Article] Type of cell death induced byα-trifluoromethyl acyloins in oral squamous cell carcinoma.2009
- Author(s)
  Ideo A, Hashimoto K, Shimada J, Kawase M, Sakagami H
- Journal Title
  
  Anticancer Res 29
  
  Pages: 175-182
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592156
[Journal Article] 2-(3-Aryl-2-propenoyl)-3-methylquinoxaline-1,4-dioxides : A Novel Cluster of Tumor-specific Cytotoxins which Reverse Multidrug Resistance.2009
- Author(s)
  U.Das, H.N.Pati, A.K.Panda, E.De Clercq, J.Balzarini, J.Molnar, Z.Barath, I.Ocsovzki, M.Kawase, H.Sakagami, J.R.Dimmock
- Journal Title
  
  Bioorg.Med.Chem. 17
  
  Pages: 3909-3915
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590114
[Journal Article] Tumor-specific Cytotoxic Activity of 1,2,3,4-Tetrahydroisoquinoline Derivatives against Human Oral Squamous Cell Carcinoma Cell Lines.2009
- Author(s)
  H.Hatano, H.Takekawa, K.Hashimoto, M.Ishihara, M.Kawase, C.Qing, W.Qin-Tao, H.Sakagami
- Journal Title
  
  Anticancer Res. 29
  
  Pages: 3079-3086
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590114
[Journal Article] Type of cell death induced by α-trifluoromethyl acyloins in oral squamous cell carcinoma.2009
- Author(s)
  A. Ideo, K. Hashimoto, J. Shimada, M. Kawase, H. Sakagami
- Journal Title
  
  Anticancer Res. 29
  
  Pages: 175-182
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590114
[Journal Article] Estimation of relationship between the structure of 1, 2, 3, 4-tetrahydroisoquinolin derivatives determined by a semiempirical molecular-orbital method and their cytotoxicity.2009
- Author(s)
  Ishihara M, Hatano H, Kawase M, Sakagami H
- Journal Title
  
  Anticancer Res 29
  
  Pages: 2265-2272
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592156
[Journal Article] The cytotoxic properties and preferential toxicity to tumour cells displayed by some 2, 4-bis(benzylidene)-8-methyl-8-azabicyclo[ 3. 2. 1]octan-3-ones and 3, 5-bis(benzylidene)-1-methyl-4-piperidones.2009
- Author(s)
  Pati HN, Das U, Bandy B, Das S, De Clercq E, Balzirini J, Kawase M, Sakagami H, Quail JW, Stables JP, Dimmock JR
- Journal Title
  
  Eur J Med Chem 44
  
  Pages: 54-62
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592156
[Journal Article] 麻酔薬の悪性腫瘍細胞に及ぼす影響について-麻酔薬,麻酔方法は転移再発に影響を与えるか?2009
- Author(s)
  長坂浩, 大野聖加, 小林克江, 坂上宏
- Journal Title
  
  麻酔
  
  Volume: 58巻 Pages: 1216-1216
- NAID
  40016836814
- Data Source
  KAKENHI-PROJECT-21591987
[Journal Article] Type of Cell Death Induced by alpha-Trifluoromethyl Acyloins in Oral Squamous Cell Carcinoma.2009
- Author(s)
  A.Ideo, K.Hashimoto, J.Shimada, M.Kawase, H.Sakagami
- Journal Title
  
  Anticancer Res. 29
  
  Pages: 175-182
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590114
[Journal Article] 麻酔薬の悪性腫瘍細胞に及ぼす影響について-麻酔薬、麻酔方法は転移再発に影響を与えるか?-2009
- Author(s)
  長坂浩, 大野聖加, 小林克江, 坂上宏
- Journal Title
  
  麻酔 58
  
  Pages: 1216-1225
- NAID
  40016836814
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591987
[Journal Article] Comparative analysis of cell death induction by cisplatin and 5-FU in human oral squamous and hepatocellular carcinoma cell lines.2008
- Author(s)
  Okamura M, Shimada J, Sakagami H
- Journal Title
  
  Anticancer Res 28
  
  Pages: 253-260
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592156
[Journal Article] Induction of apoptosis by epigallocatechin gallate and autophagy inhibitors in a mouse macrophage-like cell line2008
- Author(s)
  Hashimoto K, Sakagami H
- Journal Title
  
  Anticancer Res 28
  
  Pages: 1713-1718
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592156
[Journal Article] Quantitative structure-cytotoxicity relationship analysis of 3-formylchromone derivatives by semiempirical molecular-orbital method with concept of absolute hardness.2008
- Author(s)
  Ishihara M, Sakagami H
- Journal Title
  
  Anticancer Res 28
  
  Pages: 277-282
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592156
[Journal Article] Tumor-specific cytotoxicity and type of cell death induced by benzocycloheptoxazines in human tumor cell lines.2008
- Author(s)
  Murayama H, Miyahara K, Wakabayashi H, Kurihara T, Hashimoto K, Amano O, Kikuchi H, Nakamura Y, Kanda Y, Kunii S, Motohashi N, Sakagami H
- Journal Title
  
  Anticancer Res 28
  
  Pages: 1069-1078
- NAID
  120005520596
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592156
[Journal Article] 1-Aryl-2-dimethylaminomethyl-2-propen-1-one hydrochlorides and related adducts: a quest for selective cytotoxicity for malignant cells.2008
- Author(s)
  Pati HN, Das U, Kawase M, Sakagami H, Balzarini J, De Clercq E, Dimmock JR
- Journal Title
  
  Bioorg Med Chem 16
  
  Pages: 5747-5753
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592156
[Journal Article] Tumor-specific cytotoxicity and type of cell death induced by peplomycin in oral squamous cell carcinoma cell lines.2008
- Author(s)
  Liu Y, Sakagami H, Amano O, Kikuchi H, Nakamura Y, Ishihara M, Kanda Y, Kunii S, Zhang W, Yu G
- Journal Title
  
  Anticancer Res 28
  
  Pages: 2197-2204
- Data Source
  KAKENHI-PROJECT-19592156
[Journal Article] Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryots.2008
- Author(s)
  Klionsky D, Sakagami H, et al.
- Journal Title
  
  Autophagy 4(2)
  
  Pages: 151-175
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592156
[Journal Article] Cytotoxic 3, 5-bis(arylidene)-4-piperidones and N-acetylanalogs displaying selective toxicity for malignant cells.2008
- Author(s)
  Pati HN, Das U, Quail JW, Kawase M, Sakagami H, Dimmock JR
- Journal Title
  
  Eur J Med Chem 43
  
  Pages: 1-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592156
[Journal Article] Tumor-specific cytotoxicity and type of cell death induced by β-cyclodextrin benzaldehyde inclusion compound.2008
- Author(s)
  Liu Y, Sakagami H, Hashimoto K, Kikuchi H, Amano O, Ishihara M, Kanda Y, Kunii S, Kochi M, Zhang W, Yu G
- Journal Title
  
  Anticancer Res 28
  
  Pages: 229-236
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592156
[Journal Article] Tumor-specificity and type of cell death induced by vitamin K2 derivatives and prenylalcohols.2008
- Author(s)
  Sakagami H, Hashimoto K, Suzuki F, Ishihara M, Kikuchi H, Katayama T, Satoh K
- Journal Title
  
  Anticancer Res 28
  
  Pages: 151-158
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592156
[Journal Article] Induction of apoptosis by epigallocatechin gallate and autophagy inhibitors in a mouse macrophage-like cell line.2008
- Author(s)
  Hashimoto K, Sakagami H
- Journal Title
  
  Anticancer Res 28
  
  Pages: 1713-1718
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592156
[Journal Article] Tumor-specificity and type of cell death induced by vitamin K_2 derivatives and prenylalcohols2008
- Author(s)
  坂上宏
- Journal Title
  
  Anticancer Res 28
  
  Pages: 151-158
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592156
[Journal Article] Tumor-specificic cytotoxicity and type of cell death induced by sodium 5, 6-benzylidene-L-ascorbate.2008
- Author(s)
  Kishino K, Hashimoto K, Amano O, Kochi M, Sakagami H
- Journal Title
  
  Anticancer Res 28
  
  Pages: 2577-2584
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592156
[Journal Article] Design, synthesis and antiproliferative activity of some 3-benzylidene-2, 3-dihydro-1-benzopyran-4-ones which display selective toxicity for malignant cells.2008
- Author(s)
  Perjesi P, De Clercq E, Balzarini J, Kawase M, Sakagami H, Stables JP, Lorand T, Rozmer, Dimmock JR
- Journal Title
  
  Eur J Med Chem 43
  
  Pages: 839-845
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592156
[Journal Article] Quantitative structure-cytotoxicity relationship analysis of 5-trifluoromethyloxazole derivatives by semiempirical molecular-orbital method with concept of absolute hardness.2008
- Author(s)
  Ishihara M, Kawase M, Sakagami H
- Journal Title
  
  Anticancer Res 28
  
  Pages: 997-1004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592156
[Journal Article] Factors that affect the type of cell death induced by chemicals2007
- Author(s)
  坂上宏
- Journal Title
  
  Autophagy 3
  
  Pages: 493-495
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592156
[Journal Article] Quantitative Structure-cytotoxicity relationship analysis of phenoxazine derivatives by semiempirical molecular-orbital method.2007
- Author(s)
  Ishihara M, Kawase M, Westman G, Samuelson K, Motohashi N, Sakagami H
- Journal Title
  
  Anticancer Res 27
  
  Pages: 4053-4058
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592156
[Journal Article] 3-(3, 4, 5-Trimethoxyphenyl)-1-oxo-2-propen e: A novel phamacophore displaying potent multidrug resistance reversal and selective cytotoxicity.2007
- Author(s)
  Das U, Kawase M, Sakagami H, Ideo A, Shimada J, Molnar J, Molnar J, Barath Z, Bata Z, Dimmock JR
- Journal Title
  
  Bioorg Med Chem 15
  
  Pages: 3373-3380
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592156
[Journal Article] Tumor-specific cytotoxic activity and type of cell death induced by 4-trifluoromethylimidazoles in human oral squamous cell carcinoma cell lines.2007
- Author(s)
  Takekawa F, Nagumo T, Shintani S, Hashimoto K, Kikuchi H, Katayama T, Ishihara M, Amano O, Kawase M, Sakagami H
- Journal Title
  
  Anticancer Res 27
  
  Pages: 4065-4070
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592156
[Journal Article] Quantitative structure-activity relationship analysis of 4-trifluoromethylimidazole derivatives with the concept of absolute hardness.2007
- Author(s)
  Ishihara M, Kawase M, Sakagami H
- Journal Title
  
  Anticancer Res 27
  
  Pages: 4047-4052
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592156
[Journal Article] Tumor-specificity and type of cell death induced by phenoxazines.2007
- Author(s)
  Suzuki F, Hashimoto K, Ishihara M, Westman G, Samuelsson K, Kawase M, Motohashi N, Sakagami H
- Journal Title
  
  Anticancer Res 27
  
  Pages: 4233-4238
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592156
[Journal Article] QSAR of molecular structure and cytotoxic activity of vitamin K2 derivatives with concept of absolute hardness.2007
- Author(s)
  Ishihara M, Sakagami H
- Journal Title
  
  Anticancer Res 27
  
  Pages: 4059-4064
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592156
[Journal Article] Induction of cell death by combination treatment with cisplatin and 5-fluorouracil in a human oral squamous cell carcinoma cell line.2007
- Author(s)
  Okamura M, Kobayashi M, Suzuki F, Shimada J, Sakagami H
- Journal Title
  
  Anticancer Res 27(6)
  
  Pages: 3331-3338
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592156
[Journal Article] Factors that affect the type of cell death induced by chemicals.2007
- Author(s)
  Sakagami H, Kawase M, Wakabayashi H, Kurihara T
- Journal Title
  
  Autophagy 3
  
  Pages: 493-495
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592156
[Journal Article] Rapid changes in amino acid and polyamine metabolism during copper-induced cell death of human ginival fibroblast.2007
- Author(s)
  坂上宏
- Journal Title
  
  In Vivo 21
  
  Pages: 835-840
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592156
[Journal Article] Molecular requirement of lignin for expression o unique biological activity.2005
- Author(s)
  Sakagami H, Hashimoto K, Suzuki S, et al.
- Journal Title
  
  Phytochemistry (in press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370607
[Journal Article] Molecular requirement of lignin for expression of unique biological activity2005
- Author(s)
  Sakagami H, Hashimoto K, Suzuki S, Ogiwara T, Satoh K, Ito H, Hatano T, Yoshida T, Fujisawa S
- Journal Title
  
  Phytochemistry (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370607
[Journal Article] Cytotoxicity of nocobactins NA-a, NA-b and their ferric complexes assessed by semiempirical molecular orbital methods.2005
- Author(s)
  Sakagami H, Ishihara M, Hoshino Y et al.
- Journal Title
  
  In vivo 19(In press)
- Data Source
  KAKENHI-PROJECT-14370607
[Journal Article] Tumor-specific cytotoxicity of 3,5-dibenzoyl-1,4-dihydropyridines2005
- Author(s)
  Morshed SRM, Hashimoto K, Murotani Y, Kawase M, Shah A, Satoh K, Kikuchi H, Nishikawa H, Maki J, Sakagami H
- Journal Title
  
  Anticancer Res 25(3) (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370607
[Journal Article] Cytotoxicity of nocobactins NA-a, NA-b and their ferric complexes assessed by semiempirical molecular orbital methods2005
- Author(s)
  Sakagami H, Ishihara M, Hoshino Y, Ishikawa J, Mikami Y, Fukai T
- Journal Title
  
  In vivo 19
  
  Pages: 277-282
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370607
[Journal Article] Induction of tumor-specific cytotoxicity and apoptosis by doxorubicin2005
- Author(s)
  Suzuki F, Hashimoto K, Kikuchi H, Nishikawa H, Matsumoto H, Shimada J, Kawase M, Sunaga K, Tsuda T, Satoh K, Sakagami H
- Journal Title
  
  Anticancer Res 25
  
  Pages: 887-894
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370607
[Journal Article] 松かさリグニンの安全性2005
- Author(s)
  坂上宏
- Journal Title
  
  New Food Industry 47
  
  Pages: 55-62
- NAID
  40006646174
- Data Source
  KAKENHI-PROJECT-14370607
[Journal Article] Cytotoxicity of nocobactins NA-a, NA-b and their ferric complexes assessed by semiempirical molecular orbital methods2005
- Author(s)
  Sakagami H, Ishihara M, Hoshino Y et al.
- Journal Title
  
  In vivo 19
  
  Pages: 277-282
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370607
[Journal Article] Cytotoxicity and radical modulating activity of Moxa smoke2005
- Author(s)
  Sakagami H, Matsumoto H, Satoh K, Shioda S, Chowdhury SA, Hashimoto K, Kikuchi H, Nishikawa H, Terakubo S, Shoji Y, Nakashima H, Shimada J
- Journal Title
  
  In Vivo 19
  
  Pages: 391-398
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370607
[Journal Article] Antitumor potential of polyphenols : possible application to oral cancer therapy2005
- Author(s)
  Sakagami H, Hatano H, Takekawa H, Satoh K, Kanno M, Kawase M, Motohashi N
- Journal Title
  
  Functional Polyphenols with Antioxidative Action, a review book series of "Chem Pharmaceutical Sciences (CPS), ed. (Motohashi"("REFLASH", India) (ed)) (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370607
[Journal Article] Hydroquinone-induced apoptosis in HL-60 cells2005
- Author(s)
  Terasaka H, Morshed SRM, Hashimoto K, Sakagami H, Fujisawa S
- Journal Title
  
  Anticancer Res 25
  
  Pages: 161-170
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370607
[Journal Article] 3-Arylidene-1 -(4-nitrophenylmethylene)-3, 4-dihydro-1 H-naphthalen-2-ones and related compounds displaying selective toxicity and reversal of multidrug resistance in neoplastic cells2005
- Author(s)
  Dimmock JR, Das U, Gul HI, Kawase M, Sakagami H, Barath Z, Ocsovsky I, Molnar J
- Journal Title
  
  Bioorg Med Chem Lett 15(6)
  
  Pages: 1633-1636
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370607
[Journal Article] Inhibition of branching morphogenesis of mouse fetal submandibular gland by sodium fluoride-Protection by epidermal growth factor2005
- Author(s)
  Naka T, Maruyama S, Nagao T, Takayama F, Maki J, Yasui T, Sakagami H, Ohkawa S
- Journal Title
  
  In Vivo 19
  
  Pages: 327-334
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370607
[Journal Article] Bioactivities of Anastasia black of functional sweet pepper2005
- Author(s)
  Shirataki Y, Kawase M, Sakagami H, Nakashima H, Tani S, Tanaka T, Sohara Y, Schelz Z, Molnar J, Motohashi N
- Journal Title
  
  Anticancer Res 25 (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370607
[Journal Article] Cytotoxic activity of azulenequinones against human oral tumor cell line2005
- Author(s)
  Wakabayashi H, Nishishiro M, Arikawa S, Hashimoto K, Kikuchi H, Nishikawa H, Kurihara T, Terakubo S, Shoji Y, Nakashima H, Motohashi N, Sakagami H
- Journal Title
  
  Anticancer Res 25
  
  Pages: 305-312
- NAID
  120005520603
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370607
[Journal Article] Tumor-specific cytotoxic activity of polyphenols, terpenoids, ketones and other synthetic compounds2005
- Author(s)
  Sakagami H, Chowdhury SA, Suzuki F, Hashimoto K, Hatano H, Takekawa H, Ishihara M, Kikuchi H, Nishikawa H, Tamguchi S, Ito H, Hatano T, Yoshida T, Fukai T, Shirataki Y, Kawase M, Watanabe K, Mimaki Y, Itoh K, Horiuchi A, Chai W, Horiuchi A, Motohashi N
- Journal Title
  
  Functional Polyphenols with Antioxidative Action, a review book series of "Chem. Pharmaceutical Sciences (CPS), ed. (Motohashi"("REFLASH", India) (ed)) (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370607
[Journal Article] Tumor-specificity and apoptosis-inducing activity of stilbenes and flavonoids.2005
- Author(s)
  Chowdhury SA, Kishino K, Satoh R, Hashimoto K, Kikuchi H, Nishikawa H, Shirataki Y, Sakagami H
- Journal Title
  
  Anticancer Res 25(3) (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370607
[Journal Article] Re-evaluation of cytotoxicity and iron chelation activity of three β-diketones by semiempirical molecular orbital method.2005
- Author(s)
  Ishihara M, Sakagami H
- Journal Title
  
  In vivo 19(1)
  
  Pages: 119-124
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370607
[Journal Article] 3-Arylidene-1-(4-nitrophenylmethylene)-3,4-dihydro- 1H-naphthalen-2-ones and related compounds displaying selective toxicity and reversal of multidrug resistance in neoplastic cells.2005
- Author(s)
  Dimmock JR, Das U, Gul HI, Kawase M, Sakagami H et al.
- Journal Title
  
  Bioorg Med Chem Lett (In press)
- Data Source
  KAKENHI-PROJECT-14370607
[Journal Article] Re-evaluation of cytotoxicity and iron chelation activity of three β-diketones by semiempirical molecular orbital method.2005
- Author(s)
  Ishihara M, Sakagami H
- Journal Title
  
  In vivo 19
  
  Pages: 119-124
- Data Source
  KAKENHI-PROJECT-14370607
[Journal Article] 松かさリグニンの安全性2005
- Author(s)
  坂上宏
- Journal Title
  
  New Food Industry 47(3)
  
  Pages: 55-62
- NAID
  40006646174
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370607
[Journal Article] Cytotoxicity and radical modulating activity of Moxa smoke2005
- Author(s)
  Sakagami H, Matsumoto H, Satoh K et al.
- Journal Title
  
  In vivo 19(In press)
- Data Source
  KAKENHI-PROJECT-14370607
[Journal Article] Cytotoxicity of Nocobactions NA-a, NA-b and ther Ferric complexes assessed by semiempirical molecular orbital method2005
- Author(s)
  Sakagami H.
- Journal Title
  
  In vivo 19(1)
  
  Pages: 277-282
- Data Source
  KAKENHI-PROJECT-15659444
[Journal Article] Inhibition by Rikko-san and its major ingredients of LPS-stimulated nitric oxide production by mouse macrophage-like cells2005
- Author(s)
  Horie N, Satoh K, Hashimoto K, Shimoyama T, Kaneko T, Kusama K, Sakagami H
- Journal Title
  
  In Vivo 19(1)
  
  Pages: 165-172
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370607
[Journal Article] Four new steroidal saponins from the Rhizomes of Helleborus Orientalis.2005
- Author(s)
  Watanabe K, Sakagami H, Mimaki Y
- Journal Title
  
  Heterocycles 65(4)
  
  Pages: 775-785
- NAID
  40006693664
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370607
[Journal Article] Four new steroidal saponins from the Rhizomes of Helleborus Orientalis2005
- Author(s)
  Watanabe K, Sakagami H, Mimaki Y
- Journal Title
  
  Heterocycles 65(4)
  
  Pages: 775-785
- NAID
  40006693664
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370607
[Journal Article] Re-evaluation of cytotoxicity and iron activity of three β -diketones by semiempirical molecular orbital method2005
- Author(s)
  Ishihara M, Sakagami H
- Journal Title
  
  In vivo 19(1)
  
  Pages: 119-124
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370607
[Journal Article] Cytotoxic activity styrylchromones against human tumor cell lines2005
- Author(s)
  Momoi K, Sugita Y, Ishihara M, Satoh K, Kikuchi H, Hashimoto K, Yokoe I, Nishikawa H, Fujisawa S, Sakagami H
- Journal Title
  
  In vivo 19
  
  Pages: 157-164
- NAID
  120005520718
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370607
[Journal Article] Structure-cytotoxicity relationship of selected dietary phenols and the related compounds in tumor cells2005
- Author(s)
  Kawase M, Motohashi N, Sakagami H
- Journal Title
  
  Functional Polyphenols with Antioxidative Action, a review book series of "Chem. Pharmaceutical Sciences (CPS), ed. (Motohashi"("REFLASH", India) (ed)) (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370607
[Journal Article] Cytotoxicity of direct current with antibacterial agents against host cells in vitro.2005
- Author(s)
  Nakamura Y, Takahashi K, Uchida A, Sakagami H, Nishikawa H
- Journal Title
  
  J Endodontics (In press)
- Data Source
  KAKENHI-PROJECT-14370607
[Journal Article] Bioactivities of Anastasia black of functional sweet pepper.2005
- Author(s)
  Shirataki Y, Kawase M, Sakagami H et al.
- Journal Title
  
  Anticancer Res 25(in press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370607
[Journal Article] 培養骨芽細胞の増殖を阻害する血漿中因子について2005
- Author(s)
  高山直士, 田島雅道, 菊地寛高, 西川博文, 坂上宏, 島田淳
- Journal Title
  
  日本口腔外科学会雑誌 51(2)
  
  Pages: 67-76
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370607
[Journal Article] Protection by antioxidants of copper-induced decline of proliferation and SOD activity2005
- Author(s)
  Kinoshita N, Hashimoto K, Yamamura T, Teranuma H, Koizumi T, Satoh K, Katayana T, Sakagami H
- Journal Title
  
  Anticancer Res 25(1)
  
  Pages: 283-290
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370607
[Journal Article] Bioactivities of Anastasia black of functional sweet pepper2005
- Author(s)
  Shirataki Y, Kawase M, Sakagami H et al.
- Journal Title
  
  Anticancer Res 25(In press)
- Data Source
  KAKENHI-PROJECT-14370607
[Journal Article] Cytotoxicity and radical modulating activity of Moxa smoke.2005
- Author(s)
  Sakagami H, Matsumoto H, Satoh K, Shioda S et al.
- Journal Title
  
  In Vivo 19
  
  Pages: 391-398
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370607
[Journal Article] 培養骨芽細胞の増殖を阻害する血漿中因子について2005
- Author(s)
  高山直士, 田島雅道, 菊地寛高, 西川博文, 坂上宏, 嶋田淳
- Journal Title
  
  日本口腔外科学会雑誌 51
  
  Pages: 67-76
- Data Source
  KAKENHI-PROJECT-14370607
[Journal Article] Inhibition of Moxa smoke of NO production and iNOS expression in mouse macrophage-like cells Raw 264.72005
- Author(s)
  Matsumoto H, Shimada J, Nagasaka H, Matsumoto I, Hashimoto K, Sakagami H
- Journal Title
  
  In Vivo 19
  
  Pages: 471-474
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370607
[Journal Article] マウスマクロファージ活性化に対する多血小板血奨および洗浄血小板の効果2005
- Author(s)
  須田朋代, 菊地寛高, 高山直士, 田島雅道, 佐藤雅, 杉祐紀, 矢島晃司, 嶋田淳, 坂上宏, 西川博文
- Journal Title
  
  日歯保存誌 48
  
  Pages: 152-157
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370607
[Journal Article] 培養骨芽細胞の増殖を阻害する血漿中因子について2005
- Author(s)
  高山直士, 田島雅道, 菊地寛高, 西川博文, 坂上宏ら
- Journal Title
  
  日本口腔外科学会雑誌 51(2)
  
  Pages: 67-76
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370607
[Journal Article] Cytotoxicity of direct current with antibacterial agents against host cells in vitro2005
- Author(s)
  Nakamura Y, Takahashi K, Uchida A, Sakagami H et al.
- Journal Title
  
  J Endodontics (In press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370607
[Journal Article] Role of free radicals and metal ions in direct current-induced cytotoxicity2005
- Author(s)
  Nakamura Y, Takahashi K, Satoh K, Shimetani A, Sakagami H, Nishikawa H
- Journal Title
  
  J Endodontics (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370607
[Journal Article] Changes in fluoride sensitivity during in vitro senescence of human normal oral cells2005
- Author(s)
  Satoh R, Kishino K, Morshed SRM, Takayama F, Otsuki S, Suzuki F, Hashimoto K, Kikuchi H, Nishikawa H, Yasui T, Sakagami H
- Journal Title
  
  Anticancer Res 25 (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370607
[Journal Article] Relationship between differentiation-inducing activity and hypercalcemic activity of hexafluorotrihydroxyvitamin D3 derivatives2004
- Author(s)
  Unten S, Ishihara M, Sakagami H
- Journal Title
  
  Anticancer Res 24
  
  Pages: 683-690
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370607
[Journal Article] Relationship between electronic structure and cytotoxic activity of 3-benzazepine-related compounds2004
- Author(s)
  Kurihara T, Yamada T, Yamamoto A, Kawase M, Motohashi N, Sakagami H, Molnar J
- Journal Title
  
  Heterocyclic Chemistry. Edited by D.C.Gautam, RBSA Publishers
  
  Pages: 16-25
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370607
[Journal Article] フキノール酸のラジカル消去能について2004
- Author(s)
  渡辺悟, 田崎弘之, 三沢尚子, 佐藤和恵, 坂上宏
- Journal Title
  
  聖徳栄養短期大学紀要 35
  
  Pages: 8-13
- NAID
  110006407755
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370607
[Journal Article] Cytotoxicity and radical modulating activity of isoflavones and isoflavones from Sophora species2004
- Author(s)
  Shirataki Y, Wakae M, Yamamoto Y, Hashimoto K, Satoh K, Ishihara M, Kikuchi H, Nishikawa H, Minagawa K, Motohashi N, Sakagami H
- Journal Title
  
  Anticancer Res 24
  
  Pages: 1481-1488
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571821
[Journal Article] Effect of two different groups of Chinese medicines on nitric oxide production by mouse macrophage-like cells2004
- Author(s)
  Kaneko T, Chiba H, Horie N, Hashimoto K, Satoh K, Kusama K, Sakagami H
- Journal Title
  
  In Vivo 18(6)
  
  Pages: 771-778
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370607
[Journal Article] Structure-activity relationships of α, β -unsaturated ketones as assessed by their cytotoxicity against oral tumor cells2004
- Author(s)
  Nakayachi T, Yasumoto E, Nakano K, Morshed SRM, Hashimoto K, Kikuchi H, Nishikawa H, Kawase M, Sakagami H
- Journal Title
  
  Anticancer Res 24
  
  Pages: 737-742
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370607
[Journal Article] Functional activity of Barbados cherry (Acerola fruits, fruit of Malpighia emarginata DC.) extracts and fractions2004
- Author(s)
  Motohashi N, Wakabayashi H, Kurihara T, Fukushima H, Yamada T, Kawase M, Sohara Y, Tani S, Shirataki Y, Sakagami H, Satoh K, Nakashima H, Molnar A, Spengler G, Gyemant N, Ugocsai K, Molnar J
- Journal Title
  
  Phytother Res 18
  
  Pages: 212-223
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370607
[Journal Article] Relationship between differentiation-inducing activity and hypercalcemic activity of hexafluorotrihydroxyvitamin D_3 derivatives.2004
- Author(s)
  Unten S, Ishihara M, Sakagami H
- Journal Title
  
  Anticancer Res 24
  
  Pages: 683-690
- Data Source
  KAKENHI-PROJECT-14370607
[Journal Article] Cytotoxicity and radical modulating activity of isoflavones and isofravones from Sophora species.2004
- Author(s)
  Shirataki Y, Wakae M, Hashimoto K, Kikuchi H, Nishikawa H, Sakagami H
- Journal Title
  
  Anticancer Res 24
  
  Pages: 1481-1488
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14571821
[Journal Article] 27-Norlanostane glycosides from the Bulbs of Muscari paradoxum.2004
- Author(s)
  Kuroda M, Mimaki Y, Ori K, Sakagami H et al.
- Journal Title
  
  J Nat Prod 67(12)
  
  Pages: 2099-2103
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370607
[Journal Article] 27-Norlanostane glycosides from the Bulbs of Muscari paradoxum2004
- Author(s)
  Kuroda M, Mimaki Y, Ori K, Sakagami H, Sashida Y
- Journal Title
  
  J Nat Prod 67(12)
  
  Pages: 2099-2103
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370607
[Journal Article] 松かさリグニンの薬理作用2004
- Author(s)
  坂上宏
- Journal Title
  
  New Food Industry 46(9)
  
  Pages: 43-53
- NAID
  40006405836
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370607
[Journal Article] 著しい自発痛と開口障害を有する顎関節症に対してミニスプリントが奉効した1症例2004
- Author(s)
  中貴弘, 関雅寛, 大川周治, 天野秀雄, 坂上宏
- Journal Title
  
  明海大学歯学雑誌 33
  
  Pages: 158-162
- Data Source
  KAKENHI-PROJECT-14370607
[Journal Article] 27-Norlanostane glycosides from the Bulbs of Muscari paradoxum2004
- Author(s)
  Kuroda M, Mimaki Y, Ori K, Sakagami H, Sashisa Y
- Journal Title
  
  J Nat Prod 67
  
  Pages: 2099-2103
- Data Source
  KAKENHI-PROJECT-14370607
[Journal Article] Inhibition of LPS-stimulated NO production in mouse macrophage-like cells by tropolones2004
- Author(s)
  Yokoyama K, Hashiba K, Wakabayashi H, Hashimoto K, Satoh K, Kurihara T, Motohashi N, Sakagami H
- Journal Title
  
  Anticancer Res 24(6)
  
  Pages: 3917-3922
- NAID
  120005520605
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370607
[Journal Article] 松かさリグニンの薬理作用2004
- Author(s)
  坂上宏
- Journal Title
  
  New Food Industry 46
  
  Pages: 43-53
- NAID
  40006405836
- Data Source
  KAKENHI-PROJECT-14370607
[Journal Article] Apoptosis-inducing activity of cisplatin (CDDP) against human hepatoma and oral squamous cell carcinoma cell lines2004
- Author(s)
  Okamura M, Hashimoto K, Shimada I, Sakagami H
- Journal Title
  
  Anticancer Res 24
  
  Pages: 655-662
- Data Source
  KAKENHI-PROJECT-14370607
[Journal Article] Cytotoxic activity of deferiprone, maltol and related hydroxyketones against human tumor cell lines2004
- Author(s)
  Yasumoto E, Nakano K, Nakayachi T, Morshed SRM, Hashimoto K, Kikuchi H, Nishikawa H, Kawase M, Sakagami H
- Journal Title
  
  Anticancer Res 24
  
  Pages: 755-762
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370607
[Journal Article] Steroidal glycosides from the bulbs of ornithogalum thyrsoides2004
- Author(s)
  Kuroda M, Mimaki Y, Ori K, Sakagami H et al.
- Journal Title
  
  J Nat Prod 67(10)
  
  Pages: 1690-1696
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370607
[Journal Article] Induction of apoptosis by β -diketones in human tumor cells2004
- Author(s)
  Nakano K, Nakayachi T, Yasumoto E, Morshed SRM, Hashimoto K, Kikuchi H, Nishikawa H, Sugiyama K, Amano O, Kawase M, Sakagami H
- Journal Title
  
  Anticancer Res 24
  
  Pages: 711-718
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370607
[Journal Article] Inhibition of LPS-stimulated NO production in mouse macrophage-like cells by azulenes2004
- Author(s)
  Hashiba K, Yokoyama K, Wakabayashi H, Hashimoto K, Satoh K, Kurihara T, Motohashi N, Sakagami H
- Journal Title
  
  Anticancer Res 24(6)
  
  Pages: 3939-3944
- NAID
  120005520604
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370607
[Journal Article] Platelet-derived growth factor exerts disparate effects on odontoblast differentiation depending on the dimers in rat dental pulp cells2004
- Author(s)
  Yokose S, Kadokura H, Tajima N, Fujieda K, Katayama T, Hasegawa A, Sakagami H
- Journal Title
  
  Cell and Tissue Res 315
  
  Pages: 385-391
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370607
[Journal Article] Apoptosis-inducing activity of cisplatin(CDDP) against human hepatoma and oral squamous cell carcinoma cell lines.2004
- Author(s)
  Okamura M, Hashimoto K, Shimada J, Sakagami H
- Journal Title
  
  Anticancer Res 24
  
  Pages: 655-662
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370607
[Journal Article] フキノール酸のラジカル消去能について2004
- Author(s)
  渡辺悟, 円崎弘之, 三沢尚了, 佐藤和恵, 坂上宏
- Journal Title
  
  聖徳栄養短期大学紀要 35
  
  Pages: 8-13
- NAID
  110006407755
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370607
[Journal Article] Structure -activity relationships of a, b-unsaturated ketones as assessed by their cytotoxicity against oral tumor cells2004
- Author(s)
  Nakayachi T, Yasumoto E, Nakano K, Morshed SRM, Hashimoto K, Kikuchi H, Nishikawa H, Kawase M, Sakagami H
- Journal Title
  
  Anticancer Res 24
  
  Pages: 737-742
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571821
[Journal Article] フキノール酸のラジカル消去能について2004
- Author(s)
  渡辺悟, 田崎弘之, 三沢尚子, 佐藤和恵, 坂上宏
- Journal Title
  
  聖徳栄養短期大学紀要 35(印刷中)
- NAID
  110006407755
- Data Source
  KAKENHI-PROJECT-14370607
[Journal Article] Steroidal glycosides from the bulbs of ornithogalum thyrsoides2004
- Author(s)
  Kuroda M, Mimaki Y, Ori K, Sakagami H, Sashida Y
- Journal Title
  
  J Nat Prod 67(10)
  
  Pages: 1690-1696
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370607
[Journal Article] Cytotoxicity and radical modulating activity of isoflavones and isoflavones from Sophora species2004
- Author(s)
  Shirataki Y, Wakae M, Yamamoto Y, Hashimoto K, Satoh K, Ishihara M, Kikuchi H, Nishikawa H, Minagawa K, Motohashi N, Sakagami H
- Journal Title
  
  Anticancer Res 24
  
  Pages: 1481-1488
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370607
[Journal Article] 男性及び甲状腺ホルモンはIGF-1の発現を介してマウス胎仔顎下腺の分枝形態形成を促進する2004
- Author(s)
  丸山七朗, 長尾隆英, 峯野和良, 中貴弘, 大川周治, 坂上宏, 栗原琴二, 外崎肇一, 柏俣正典, Edward W, Gresik
- Journal Title
  
  日本唾液腺学会誌 45
  
  Pages: 84-87
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370607
[Journal Article] Steroidal glycosides from the bulbs of ornithogalum thyrsoides.2004
- Author(s)
  Kuroda M, Mimaki Y, Ori K, Sakagami H, Sashida Y
- Journal Title
  
  J Nat Prod 67
  
  Pages: 1690-1696
- Data Source
  KAKENHI-PROJECT-14370607
[Journal Article] 男性及び甲状腺ホルモンはIGF-1の発現を介してマウス胎仔顎下腺の分枝形態形成を促進する2004
- Author(s)
  丸山七朗, 長尾隆英, 峯野和良, 中貴弘, 大川周治, 坂上宏ら
- Journal Title
  
  日本唾液腺学会誌 45
  
  Pages: 84-87
- Data Source
  KAKENHI-PROJECT-14370607
[Journal Article] Biological activity of an Indian medical plant, Indigofera cordifolia2004
- Author(s)
  Rao BK, Kawase M, Tanaka T, Tani S, Motohashi N, Satoh K, Sakagami H, Terakubo S, Nakashima H, Wolfard K, Molnar J
- Journal Title
  
  Orient Pharm Exp Med 4(3)
  
  Pages: 179-185
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370607
[Journal Article] Apoptosis-inducing activity of cisplatin (CDDP) against human hepatoma and oral squamous cell carcinoma cell lines2004
- Author(s)
  Okamura M, Hashimoto K, Shimada J, Sakagami H
- Journal Title
  
  Anticancer Res 24
  
  Pages: 655-662
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370607
[Journal Article] Structure-activity relationships of a, b-unsaturated ketones as assessed by their cytotoxicity against oral tumor cells.2004
- Author(s)
  Nakayachi T, Yasumoto E, Nakano K, Hashimoto K, Kikuchi H, Sakagami H
- Journal Title
  
  Anticancer Res 24
  
  Pages: 737-742
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14571821
[Journal Article] クロロゲン酸のDPPHラジカル消去活性とマウスマクロファージ様細胞に対する効果について2003
- Author(s)
  渡辺悟, 三沢尚子, 坂上宏
- Journal Title
  
  聖徳栄養短期大学紀要 34
  
  Pages: 7-12
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370607
[Journal Article] Cytotoxic activity of tropolones against human oral tumor cell lines.2003
- Author(s)
  Wakabayashi H, Yokoyama K, Hashiba K, Hashimoto K, Kikuchi H, Nishikawa H, Kurihara T, Sakagami H
- Journal Title
  
  Anticancer Res 23
  
  Pages: 2385-2389
- NAID
  120005520607
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14571821
[Journal Article] Cytotoxic activity of tropolones against human oral tumor cell lines2003
- Author(s)
  Wakabayashi H, Yokoyama K, Hashiba K, Hashimoto K, Kikuchi H, Nishikawa H, Kurihara T, Satoh K, Shioda S, Muto S, Terakubo S, Nakashima H, Motohashi N, Sakagami H
- Journal Title
  
  Anticancer Res 23
  
  Pages: 2385-2389
- NAID
  120005520607
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571821
[Journal Article] Cytotoxic activity of azulenes against human oral tumor cell lines2003
- Author(s)
  Wakabayashi H, Hashiba K, Yokoyama K, Hashimoto K, Kikuchi H, Nishikawa H, Kurihara T, Satoh K, Shioda S, Saito S, Kusano S, Nakashima H, Motohashi N, Sakagami H
- Journal Title
  
  Anticancer Res 23
  
  Pages: 3237-3241
- NAID
  120005520608
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571821
[Journal Article] Cytotoxic activity of azulenes against human oral tumor cell lines.2003
- Author(s)
  Wakabayashi H, Hashiba K, Yokoyama K, Hashimoto K, Kikuchi H, Nishikawa H, Kurihara T, Sakagami H
- Journal Title
  
  Anticancer Res 23
  
  Pages: 3237-3241
- NAID
  120005520608
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14571821
[Journal Article] クロロゲン酸のDPPHラジカル消去活性とマウスマクロファージ様細胞対する効果について2003
- Author(s)
  渡辺悟, 三沢尚子, 坂上宏
- Journal Title
  
  聖徳栄養短期大学紀要 34
  
  Pages: 7-12
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370607
[Journal Article] Hydrolyzable tannins of tamaricaceous plants III. New Hellinoyl and macrocyclic types ellagitannins from Tamarix nilotica.
- Author(s)
  Orabi MAA, Taniguchi S, Yoshimura M, Yoshida T, Kishino K, Sakagami H, Hatano T
- Journal Title
  
  J Nat Prod (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592156
[Journal Article] Cytotoxicity of direct current with antibacterial agents against host cells in vitro
- Author(s)
  Nakamura Y, Takahashi K, Uchida A, Sakagami H, Nishikawa H
- Journal Title
  
  J Endodontics (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370607
[Journal Article] 活性酸素と老化、耳よりな話トピック
- Author(s)
  坂上宏
- Journal Title
  
  Hone-Kenko 8月号
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370607
[Journal Article] Apoptosis-inducing activity and tumor-specificity of antitumor agents against oral squamous cell carcinoma.
- Author(s)
  Sakagami H
- Journal Title
  
  Japanese Dental Science Review (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592156
[Journal Article] Cytotoxicity and Type of Cell Death Induced by Local Anesthetics against Human Oral Normal and Tumor cells
- Author(s)
  Kobayashi K, Ohno S, Uchida S, Amano O, Sakagami H, Nagasaka H
- Journal Title
  
  Anticancer Res
  
  Volume: (In press)
- Data Source
  KAKENHI-PROJECT-21591987
[Journal Article] 1, 3-Diaryl-2-propenones and 2-benzylidene-1, 3-indandiones: A quest for compounds displaying greater toxicity to neoplasms than normal cells.
- Author(s)
  Pati HN, Das U, Sakagami H, Kawase M, Chu Q, Wang Q, Stables JP, Dimmock JR
- Journal Title
  
  Archiv der Pharmazie (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592156
[Patent] 新規タンニン誘導体2011
- Inventor(s)
  波多野力、竹内靖雄、坂上宏
- Industrial Property Rights Holder
  波多野力、竹内靖雄、坂上宏
- Industrial Property Number
  2011-016195
- Filing Date
  2011-01-28
- Data Source
  KAKENHI-PROJECT-22580128
[Patent] 新規タンニン誘導体2011
- Inventor(s)
  波多野力、竹内靖雄、坂上宏
- Industrial Property Rights Holder
  波多野力、竹内靖雄、坂上宏
- Filing Date
  2011-01-28
- Data Source
  KAKENHI-PROJECT-22580128
[Presentation] ヒト口腔扁平上皮がん細胞に対する抗がん剤および過酸化水素とマイルドハイパーサーミアの併用効果2021
- Author(s)
  田川裕也、坂上宏、天野滋、友村美根子、坂東健二郎、高尾浩一、杉田義昭、植沢芳広、山本信治、坂下英明、中鍛治里奈、小泉敏之、光藤健司、藤内祝
- Organizer
  ハイパーサーミア学会
- Data Source
  KAKENHI-PROJECT-20H03893
[Presentation] 口腔がん細胞に対する抗がん剤および過酸化水素とマイルドハイパーサーミアの併用効果2021
- Author(s)
  田川裕也１）、坂上宏２）、天野滋２）、山本信治１）、坂下英明１）、中鍛治里奈３）、小泉敏之４）、光藤健司４）、藤内祝５）
- Organizer
  口腔外科学会
- Data Source
  KAKENHI-PROJECT-20H03893
[Presentation] X線照射誘導性細胞傷害に対する抗酸化剤の保護効果の測定法の検討2019
- Author(s)
  坂上宏, 中谷儀一郎, 小川由香里, 白戸亮吉, 上田大輔, 延澤忠真, 中谷祥恵, 古旗賢二, 松田玲於奈, 田村暢章, 竹島浩
- Organizer
  第140回日本薬理学会関東部会
- Data Source
  KAKENHI-PROJECT-17K12055
[Presentation] X線照射誘発性PC12神経細胞傷害に及ぼすNGFの保護効果2019
- Author(s)
  坂上宏, 中谷儀一郎, 小川由香里, 白戸亮吉, 上田大輔, 延澤忠真, 中谷祥恵, 古旗賢二, 松田玲於奈, 田村暢章, 刀祢重信, 坂東健二郎, 友村美根子, 友村明人, 竹島浩, 鬼頭慎司
- Organizer
  第141回日本薬理学会関東部会
- Data Source
  KAKENHI-PROJECT-17K12055
[Presentation] 口腔癌選択毒性を示す化合物の探索を目的としたQSAR予測モデルの構築2019
- Author(s)
  今村舞衣、永井純子、坂上宏、植沢芳広
- Organizer
  第139回薬学会年会、幕張、千葉
- Data Source
  KAKENHI-PROJECT-16K11519
[Presentation] 全自動アミノ酸分析計を用いた唾液及び日本酒の成分分析：水中運動の効果2019
- Author(s)
  鈴木龍一郎, 田村暢章, 坂上宏, 竹島浩, 水野加寿
- Organizer
  第59回日本臨床化学会年次学術集会
- Data Source
  KAKENHI-PROJECT-17K12055
[Presentation] 2-(N-cyclicamino)chromone誘導体の定量的構造‐細胞傷害性相関解析2018
- Author(s)
  植沢芳広、史海霞、永井純子、坂詰つかさ、坂東健二郎、坂上宏、友村美根子、友村明人、高尾浩一、杉田義昭
- Organizer
  第139回日本薬理学会関東部会、東京慈恵会医科大学、東京
- Data Source
  KAKENHI-PROJECT-16K11519
[Presentation] ササヘルスによるホルメシスおよび神経細胞保護効果の誘導2018
- Author(s)
  坂上　宏、友村美根子、友村明人、増田宜子、横瀬敏志、岩間聡一、中川美香、鈴木隼人、田中健大、阿部智之、大石洋平、田村暢章、竹島　浩、安井利一、辻まゆみ木内祐二、小口勝司、堀内美咲、藤澤知弘、勝呂まどか、大泉浩史、大泉高明
- Organizer
  第138回日本薬理学会関東部会
- Data Source
  KAKENHI-PROJECT-17K12055
[Presentation] Aβ誘発性神経細胞死に対する抑制物質の探索2018
- Author(s)
  2.田村暢章，坂上　宏，岩間聡一，中川美香，鈴木隼人，田中健大，阿部智之，竹島　浩
- Organizer
  日本老年歯科医学会第29回学術大会
- Data Source
  KAKENHI-PROJECT-17K12055
[Presentation] 第30回日本小児口腔外科学会総会・学術大会、川越、埼玉2018
- Author(s)
  坂上　宏
- Organizer
  天然物資源の口腔疾患治療への応用（特別講演）
- Invited
- Data Source
  KAKENHI-PROJECT-16K11519
[Presentation] 3-(N-サイクリックアミノ)クロモン誘導体の定量的構造‐細胞傷害性相関解析2018
- Author(s)
  坂上宏、史　海霞、永井純子、坂詰つかさ、坂東健二郎、奥平　准之、植沢芳広、友村美根子、友村明人、高尾浩一、杉田義昭
- Organizer
  第139回日本薬理学会関東部会、東京慈恵会医科大学、東京
- Data Source
  KAKENHI-PROJECT-16K11519
[Presentation] ピラノ[4,3-b]クロモン誘導体の定量的構造‐細胞傷害性相関解析2018
- Author(s)
  永井純子、史海霞、久保田夕香、坂東健二郎、奥平准之、植沢芳広、坂上宏、友村美根子、友村明人、高尾浩一、杉田義昭
- Organizer
  第139回日本薬理学会関東部会、東京慈恵会医科大学、東京
- Data Source
  KAKENHI-PROJECT-16K11519
[Presentation] フラノクロモン誘導体の定量的構造‐細胞傷害性相関解析2017
- Author(s)
  植沢芳広、高尾浩一、杉田義、加賀谷肇、奥平准之、坂上宏
- Organizer
  第138回日本薬理学会関東部会、慶応義塾大学薬学部、東京
- Data Source
  KAKENHI-PROJECT-16K11519
[Presentation] ササヘルスのアミロイドペプチド誘発性神経細胞傷害に対する保護作用2017
- Author(s)
  坂上　宏、増田宜子、友村美根子、横瀬敏志、友村明人、岩間聡一、中川美香、鈴木隼人、田中健大、阿部智之、大石洋平、田村暢章、竹島　浩、鈴木龍一郎、白瀧義明、辻まゆみ、木内裕二、堀江憲夫、名取威徳、堀内美咲、勝呂まどか、大泉浩史、大泉高明
- Organizer
  第137回日本薬理学会関東部会
- Data Source
  KAKENHI-PROJECT-17K12055
[Presentation] ヒト肝がん由来細胞株HepG2に対する3-styrylchromone誘導体の抗腫瘍効果2017
- Author(s)
  内田知里、小澤知佳、菊地秀与、高尾浩一、杉田義昭、坂上宏、津田整、須永克佳
- Organizer
  日本薬学会第138年会、金沢
- Data Source
  KAKENHI-PROJECT-16K11519
[Presentation] オーロン誘導体の定量的構造‐細胞傷害性相関解析2017
- Author(s)
  植沢芳広、坂上宏、池添成彦、高尾浩一、加賀谷肇、杉田義昭
- Organizer
  第137回日本薬理学会関東部会、日本医科大学、東京
- Data Source
  KAKENHI-PROJECT-16K11519
[Presentation] ピペリン酸エステル誘導体の構造活性相関：腫瘍選択性とアポトーシス誘導2017
- Author(s)
  坂上宏、植沢芳広、増田宜子、友村美根子、金本大成、寺久保繁美、宮城昂幹、村井淳一、高尾浩一、横瀬敏志、加賀谷肇、中島秀喜、杉田義昭
- Organizer
  第137回日本薬理学会関東部会、日本医科大学、東京
- Data Source
  KAKENHI-PROJECT-16K11519
[Presentation] ドキソルビシンのヒト口腔ケラチノサイトに対する傷害性を緩和する物質の探索2016
- Author(s)
  坂上宏、奥平准之、天野修、横瀬敏志
- Organizer
  第58回歯科基礎医学会総会
- Place of Presentation
  札幌コンベンションセンター
- Year and Date
  2016-08-24
- Data Source
  KAKENHI-PROJECT-16K11519
[Presentation] 3-Benzylidenechromanonesの定量的構造‐細胞傷害性相関解析2016
- Author(s)
  植沢芳広、坂上宏、山下毬藻、高尾浩一、杉田義昭
- Organizer
  第134回日本薬理学会関東部会
- Place of Presentation
  国際医療福祉大学薬学部、大田原市、栃木
- Data Source
  KAKENHI-PROJECT-16K11519
[Presentation] Chemistry, cytotoxicity, and in vitro production of hydrolyzable tannins of Tamarix species2015
- Author(s)
  Orabi MA，谷口抄子，坂上宏，、好村守生，天倉吉章，波多野力
- Organizer
  第6回食品薬学シンポジウム
- Place of Presentation
  岡山市
- Year and Date
  2015-10-30
- Data Source
  KAKENHI-PROJECT-25450170
[Presentation] 未利用植物資源由来タンニンの化学構造と生物活性2015
- Author(s)
  加藤沙友里，山﨑真菜，下津祐樹，青山弘枝，黒田照夫，坂上宏，波多野力
- Organizer
  第6回食品薬学シンポジウム
- Place of Presentation
  岡山市
- Year and Date
  2015-10-30
- Data Source
  KAKENHI-PROJECT-25450170
[Presentation] ハンカチノキの成分（第2報）2015
- Author(s)
  木村優里子, 青山弘枝, 下津祐樹, 坂上　宏, 波多野　力
- Organizer
  日本生薬学会第62回年会
- Place of Presentation
  岐阜市
- Year and Date
  2015-09-11
- Data Source
  KAKENHI-PROJECT-25450170
[Presentation] メタボロミクスの手法を利用した抗口腔がん活性を有する天然素材の探索2014
- Author(s)
  鈴木龍一郎、松野慎平、渡部美緒、坂上宏、岡田嘉仁、白瀧義明
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-25670897
[Presentation] クマザサ葉アルカリ抽出液によるIL-1β刺激ヒト歯肉および歯根膜線維芽細胞のPGE2産生の抑制2014
- Author(s)
  坂上　宏、大越絵実加、加藤崇雄、下山哲夫、北嶋まどか、大泉浩史、大泉高明
- Organizer
  第87回日本薬理学会年会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-25670897
[Presentation] (E)-3-(4-Hydroxystyryl)- 6-methoxy-4H-chromen-4-oneのヒト口腔扁平上皮癌細胞に対する選択毒性の解析2014
- Author(s)
  坂上宏、嶋田智哉子、神田由未子、天野修、杉本昌弘、高尾浩一、杉田義昭
- Organizer
  第131回日本薬理学会関東部会
- Place of Presentation
  横浜
- Year and Date
  2014-10-11
- Data Source
  KAKENHI-PROJECT-25670897
[Presentation] クマ笹アルカリ抽出液のヒト歯肉線維芽細胞に対する抗炎症効果の解析2014
- Author(s)
  坂上宏、大越絵実加、加藤崇雄、下山哲夫、北嶋まどか、賈俊業、大泉高明、杉本昌弘
- Organizer
  第56回歯科基礎医学会学術大会・総会
- Place of Presentation
  福岡
- Year and Date
  2014-09-25
- Data Source
  KAKENHI-PROJECT-25670897
[Presentation] 口腔扁平上皮癌細胞死誘導における代謝物変動の網羅的メタボローム解析2013
- Author(s)
  坂上　宏、杉本昌弘
- Organizer
  日本口腔組織培養学会設立50周年記念学術大会
- Place of Presentation
  日本歯科大学　生命歯学部九段ホール
- Data Source
  KAKENHI-PROJECT-25670897
[Presentation] ミダゾラムによりヒト口腔扁平上皮癌細胞に誘導される細胞死のタイプの検討2010
- Author(s)
  大野聖加, 小林克江, 内田茂則, 坂上宏, 長坂浩
- Organizer
  第38回日本歯科麻酔学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-21591987
[Presentation] アドレナリン作用薬とdexmedetomidineによってヒト口腔扁平上皮癌細胞に誘導される細胞死の検討2010
- Author(s)
  内田茂則, 大野聖加, 小林克江, 坂上宏, 長坂浩
- Organizer
  第38回日本歯科麻酔学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-21591987
[Presentation] タンニンータンパク質複合体のヒト癌細胞株に対する腫瘍選択性と誘導される細胞死のタイプ2010
- Author(s)
  坂上宏, 岸野香織, 橋本研, 野崎阿季子, 波多野力
- Organizer
  第83回日本薬理学会年会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-19592156
[Presentation] 半経験的分子軌道法を用いた新規Trihaloacetylazulene誘導体の分子構造と細胞傷害活性の相関関係の予測2010
- Author(s)
  石原真理子, 坂上宏
- Organizer
  第83回日本薬理学会年会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-19592156
[Presentation] Cytotoxicity of local anesthetics against human normal and tumor cells2009
- Author(s)
  Kobayashi K, Ohno S, Uchida S, Sakagami H, Nagasaka H
- Organizer
  12th International Dental Congress on Modern Pain Control
- Data Source
  KAKENHI-PROJECT-21591987
[Presentation] ミダゾラムによりヒト口腔扁平上皮癌細胞に誘導される細胞死のタイプの検討2009
- Author(s)
  大野聖加, 小林克江, 内田茂則, 坂上宏, 長坂浩
- Organizer
  第37回日本歯科麻酔学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-21591987
[Presentation] Type of cell death induced by midazolam, intravenous anesthetic, in several tumor cell2009
- Author(s)
  Ohno S, Kobayashi K, Uchida S, Sakagami H, Nagasaka H
- Organizer
  12th International Dental Congress on Modern Pain Control
- Data Source
  KAKENHI-PROJECT-21591987
[Presentation] ヒト口腔癌細胞の細胞死誘導におけるDNaseγの役割2009
- Author(s)
  橋本研, 坂上宏
- Organizer
  第82回日本薬理学会年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19592156
[Presentation] Unique biological activities of high molecular-weight nolyphenols : possible application for the oral health2009
- Author(s)
  Sakagami H
- Organizer
  INSA Platinum Jubilee International Symposium
- Place of Presentation
  Pune, India
- Year and Date
  2009-11-21
- Data Source
  KAKENHI-PROJECT-19592156
[Presentation] ジブカインはヒト口腔扁平上皮癌細胞に非アポトーシスを誘導する2009
- Author(s)
  小林克江, 大野聖加, 内田茂則, 坂上宏, 長坂浩
- Organizer
  第37回日本歯科麻酔学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-21591987
[Presentation] ベンズアルデヒドによりヒト口腔扁平上皮癌細胞に誘導される細胞死の解析2009
- Author(s)
  岸野香織, 橋本研, 天野修, 坂上宏
- Organizer
  第51回歯科基礎医学会
- Place of Presentation
  新潟
- Data Source
  KAKENHI-PROJECT-19592156
[Presentation] Induction of non-apoptosis by a, b-unsaturated ketones in OSCC cell lines2008
- Author(s)
  Sakagami H, Hashimoto K, Ishihara M, Nagasaka H, Kawase M, Dimmock J
- Organizer
  IADR
- Place of Presentation
  Toronto
- Data Source
  KAKENHI-PROJECT-19592156
[Presentation] 複素環式化合物の腫瘍選択性と誘導される細胞死のタイプ2008
- Author(s)
  坂上宏, 橋本研, 小林正樹, 鈴木史香, 竹川文弘石原真理子, 天野修, 菊地寛高, 中村幸生, 河瀬雅美, 本橋登
- Organizer
  第81回日本薬理学会年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19592156
[Presentation] Induction of non-apoptosis by α, β-unsaturated ketones in OSCC cell lines2008
- Author(s)
  Sakagami Hら(6名)
- Organizer
  86^<th> General Session of IADR
- Place of Presentation
  トロント
- Year and Date
  2008-07-03
- Data Source
  KAKENHI-PROJECT-19592156
[Presentation] キンポウゲ科植物の化学成分(17)Adonis amurensisの成分について(3)2008
- Author(s)
  黒田民平, 内田真吾, 三巻祥浩, 坂上宏
- Organizer
  日本生薬学会第55回年会
- Place of Presentation
  長崎
- Data Source
  KAKENHI-PROJECT-19592156
[Presentation] Functional evaluation of polyphenols as alternative medicine2007
- Author(s)
  Sakagami H
- Organizer
  3rd International conference of polyphenols and health
- Place of Presentation
  京都国際会議場
- Year and Date
  2007-11-26
- Data Source
  KAKENHI-PROJECT-19592156
[Presentation] ベンズアルデヒド類のヒト口腔扁平上皮癌細胞に対する選択毒性2007
- Author(s)
  坂上宏, 劉宇, 岸野香織, 小林正樹, 橋本研, 石原真理子
- Organizer
  第49回歯科基礎医学会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-19592156
[Presentation] 抗菌作用及び抗腫瘍作用を有するタンニン類縁体の合成
- Author(s)
  西岡弘美、渡邉聡子、小川卓也、黒田照夫、坂上宏、波多野力、竹内靖雄
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸市
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-25450170
[Presentation] Phenolic constituents of Feijoa sellowiana
- Author(s)
  Aoyama H, Kuroda T, Sakagami H, Hatano T
- Organizer
  27th International Conference on Polyphenols
- Place of Presentation
  Nagoya University
- Year and Date
  2014-09-02 – 2014-09-06
- Data Source
  KAKENHI-PROJECT-25450170
[Presentation] ハンカチノキの成分（第一報）
- Author(s)
  木村優里子、青山弘枝、下津祐樹、黒田照夫、坂上宏、波多野力
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸市
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-25450170
[Presentation] Metabolic profiling of 3-styrylchromone-induced cytotoxicity in an oral squamous cell carcinoma cell line
- Author(s)
  Sakagami H, Shimada C, Kanda Y, Amano O, Sugimoto M, Takao K and Sugita Y
- Organizer
  第88回日本薬理学会年会
- Place of Presentation
  名古屋
- Year and Date
  2015-03-18 – 2015-03-20
- Data Source
  KAKENHI-PROJECT-25670897

1. KAWASE Masami (20112641)

# of Collaborated Projects: 3 results

# of Collaborated Products: 56 results
2. NAGASAKA Hiroshi (10189110)

# of Collaborated Projects: 3 results

# of Collaborated Products: 9 results
3. SUGIMOTO Masahiro (30458963)

# of Collaborated Projects: 3 results

# of Collaborated Products: 8 results
4. OKUDIRA NORIYUKI (10635585)

# of Collaborated Projects: 3 results

# of Collaborated Products: 8 results
5. BANDOW KENJIRO (50347093)

# of Collaborated Projects: 3 results

# of Collaborated Products: 9 results
6. 杉田義昭 (20255029)

# of Collaborated Projects: 3 results

# of Collaborated Products: 20 results
7. 高尾浩一 (70337484)

# of Collaborated Projects: 3 results

# of Collaborated Products: 20 results
8. 植沢芳広 (90322528)

# of Collaborated Projects: 3 results

# of Collaborated Products: 21 results
9. MIMAKI Yoshihiro (90229790)

# of Collaborated Projects: 2 results

# of Collaborated Products: 17 results
10. HATANO Tsutomu (50127578)

# of Collaborated Projects: 2 results

# of Collaborated Products: 10 results
11. TAKEUCHI Yasuo (00163387)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
12. KATAYAMA Tadashi (10105596)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
13. UMEMURA Naoki (80609107)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
14. SAKASHITA Hideaki (10178551)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
15. KUSAMA Kaoru (20130479)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
16. KIKUCHI Hirotaka (70234193)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
17. 川添豊 (80106252)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
18. 貝谷トヨ (10080201)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
19. 友村美根子 (30217559)

# of Collaborated Projects: 2 results

# of Collaborated Products: 12 results
20. 天野滋 (90167958)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
21. HASHIMOTO Ken (70343457)

# of Collaborated Projects: 1 results

# of Collaborated Products: 20 results
22. HAGIMOTO Yuri (30435078)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. ISHIHARA Sachiyo (10223017)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. TANAKA Shoji (60105616)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
25. KASHIMATA Masanori (30152630)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. FUKUDA Masakatsu (10311614)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. FUJISAWA Sei-ichtro (40014162)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. YOSHIDA Takashi (20025696)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
29. TAKEDA Ken (80054013)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. IWAMOTO Sanju (50176567)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. NAGAI JUNKO (50828142)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
32. TAMURA NOBUAKI (00363218)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
33. SUDA Naoto (90302885)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
34. 石原真理子 (50095329)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
35. 岩坂憲助 (60424058)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
36. 山本美朗 (40049383)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
37. 須永克佳 (70236040)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
38. 田島雅道 (70130995)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
39. 村上幸生 (00286014)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
40. 鈴木龍一郎 (20415201)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
41. 竹島浩 (90216888)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
42. 白瀧義明 (60077980)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
43. 増田宜子 (10297038)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
44. 村本和世 (10301798)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
45. 安達一典 (20349963)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
46. 田沼靖一 (10142449)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
47. 佐藤聡 (40530663)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
48. 藤内祝 (50172127)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
49. 山本信治 (60385185)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
50. 光藤健司 (70303641)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
51. 小泉敏之 (80323575)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
52. 中鍛治里奈 (80845511)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
53. FUJISAWA Seiichiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
54. 友村明人

# of Collaborated Projects: 0 results

# of Collaborated Products: 7 results
55. 菊池寛高

# of Collaborated Projects: 0 results

# of Collaborated Products: 8 results
56. 大越絵実加

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
57. 村上宜子

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
58. 曽我朋義

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
59. 加賀谷肇

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

SAKAGAMI Hiroshi 坂上 宏

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Elucidation of selective cytotoxicity against malignant cells by chromone derivativesPrincipal Investigator

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Basic study of the possibility of newly synthesized 3-styrylchromone derivatives as therapeutic drugs for oral cancerPrincipal Investigator

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Development of salivary aging marker that reflects the collagen metabolitesPrincipal Investigator

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Basic research for the development of autophagy-inducing therapy against human oral squamous cell carcinoma cell linesPrincipal Investigator

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SAKAGAMI Hiroshi 坂上宏