takao koichi 高尾浩一

… Alternative Names

高尾浩一タカオコウイチ

TAKAO Koichi 高尾浩一

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Researcher Number	70337484
Other IDs
Affiliation (Current)	2022: 城西大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2022: 城西大学, 薬学部, 教授 2020 – 2022: 城西大学, 薬学部, 准教授 2017 – 2018: 城西大学, 薬学部, 准教授 2016: 城西大学, 薬学部, 助教 2004 – 2006: 城西大学, 薬学部, 助手
Review Section/Research Field	Except Principal Investigator Physical pharmacy / Pathobiological dentistry/Dental radiology / Basic Section 57010:Oral biological science-related / Basic Section 57060:Surgical dentistry-related / Basic Section 59040:Nutrition science and health science-related
Keywords	Except Principal Investigator クロモン誘導体 / PSD / ポリアミン / 腫瘍選択性 / 口腔扁平上皮癌細胞 / 選択毒性 / コンホメーション変化 / 蛍光SH基標識試薬 / C末端標識法 / MALDI-TOF MS … More / グアニジン / 蛍光検出HPLC / アミノ酸配列分析 / Conformational change / Fluorescent labeling agent for sulfhydryl groups / C-terminal labeling / MALDI-TOFHS / Polyamine / クロモン環 / アポトーシス / 分子軌道解析 / 細胞周期 / カスパーゼ-3 / QSAR解析 / 3次元構造 / アポトーシス誘導能 / subG1 / スチリルクロモン / ピペリン酸エステル / オーロン / QSAR / 置換基 / 化学記述子 / 3-スチリルクロモン類 / ヒト口腔扁平上皮癌 / 有機合成 / 作用機序 / 副作用の緩和 / 構造活性相関 / 抗炎症効果 / キナーゼ阻害活性 / パスウェイ解析 / 細胞死のタイプ / ヒト口腔扁平上皮がん細胞 / 細胞への取り込み / クロモン誘導体の標識 / 作用点 / 遺伝子発現 / 代謝物変化 / 細胞死 / 口腔扁平上皮癌 / シグナル伝達 / ハイパーサーミア / 低侵襲性治療 / 腫瘍選択性磁性体 / 口腔癌 / 併用療法 / マイルドハイパーサーミア / ハイパーサミア / 細胞透過性ペプチド / Geranylgeraniol / 老化 / スペルミン酸化酵素 Less

加齢によるスペルミン分解活性化機構解明と新規抗老化物質の創出
- Principal Investigator
  
  植村武史
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Josai University
Elucidation of selective cytotoxicity against malignant cells by chromone derivatives
- Principal Investigator
  
  坂上宏
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57010:Oral biological science-related
- Research Institution
  Meikai University
Development of minimally invasive therapy for oral cancer by hyperthermia with tumor-specific targeting magnetic nanoparticles
- Principal Investigator
  
  藤内祝
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Meikai University
Basic study of the possibility of newly synthesized 3-styrylchromone derivatives as therapeutic drugs for oral cancer
- Principal Investigator
  
  Sakagami Hiroshi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathobiological dentistry/Dental radiology
- Research Institution
  Meikai University
Proteome analysis as an index of conformational change of protein
- Principal Investigator
  
  SHIRAHATA Akira
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Josai University

All 2022 2021 2020 2018 2017 2016 2006

All Journal Article Presentation

[Journal Article] A Dual Anti-Inflammatory and Anti-Proliferative 3-Styryl-chromone Derivative Synergistically Enhances the Anti-Cancer Effects of DNA-Damaging Agents on Colon Cancer Cells by Targeting HMGB1-RAGE-ERK1/2 Signaling2022
- Author(s)
  Tanuma Sei-ichi、Oyama Takahiro、Okazawa Miwa、Yamazaki Hiroaki、Takao Koichi、Sugita Yoshiaki、Amano Shigeru、Abe Takehiko、Sakagami Hiroshi
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Pages: 3426-3426
- DOI
  10.3390/ijms23073426
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K09885
[Journal Article] A 3-styrylchromone converted from trimebutine 3D pharmacophore possesses dual suppressive effects on RAGE and TLR4 signaling pathways2021
- Author(s)
  Okazawa Miwa、Oyama Takahiro、Abe Hideaki、Yamazaki Hiroaki、Yoshimori Atsushi、Tsukimoto Mitsutoshi、Yoshizawa Kazumi、Takao Koichi、Sugita Yoshiaki、Kamiya Takanori、Uchiumi Fumiaki、Sakagami Hiroshi、Abe Takehiko、Tanuma Sei-ichi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 566 Pages: 1-8
- DOI
  10.1016/j.bbrc.2021.05.096
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K09885
[Journal Article] A Unique Anti-Cancer 3-Styrylchromone Suppresses Inflammatory Response via HMGB1-RAGE Signaling2021
- Author(s)
  Abe Hideaki、Okazawa Miwa、Oyama Takahiro、Yamazaki Hiroaki、Yoshimori Atsushi、Kamiya Takanori、Tsukimoto Mitsutoshi、Takao Koichi、Sugita Yoshiaki、Sakagami Hiroshi、Abe Takehiko、Tanuma Sei-ichi
- Journal Title
  
  Medicines
  
  Volume: 8 Pages: 17-17
- DOI
  10.3390/medicines8040017
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09885, KAKENHI-PROJECT-18H02685
[Journal Article] 腫瘍選択性が高く、副作用が低い新規クロモン誘導体の開発2020
- Author(s)
  坂上宏、杉田義昭、高尾浩一、永井純子、植沢芳広、飯島洋介、佐野元彦
- Journal Title
  
  New Food Industry
  
  Volume: 62 (12) Pages: 871-881
- NAID
  40022428470
- Data Source
  KAKENHI-PROJECT-20K09885
[Journal Article] Quantification of the ability of natural products to prevent herpes virus infection2020
- Author(s)
  Fukuchi Kunihiko、Sakagami Hiroshi、Sugita Yoshiaki、Takao Koichi、Asai Daisuke、Terakubo Shigemi、Takemura Hiromu、Ohno Hirokazu、Horiuchi Misaki、Suguro Madoka、Fujisawa Tomohiro、Toeda Kazuki、Oizumi Hiroshi、Yasui Toshikazu、Oizumi Takaaki
- Journal Title
  
  Medicines (Basel)
  
  Volume: 7 Pages: 64-64
- DOI
  10.3390/medicines7100064
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09885, KAKENHI-PROJECT-20K12657, KAKENHI-PROJECT-17K08254
[Journal Article] Development of Newly Synthesized Chromone Derivatives with High Tumor Specificity against Human Oral Squamous Cell Carcinoma2020
- Author(s)
  Sugita Yoshiaki、Takao Koichi、Uesawa Yoshihiro、Nagai Junko、Iijima Yosuke、Sano Motohiko、Sakagami Hiroshi
- Journal Title
  
  Medicines
  
  Volume: 7 Pages: 50-50
- DOI
  10.3390/medicines7090050
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09885
[Journal Article] Quantitative Structure-Cytotoxicity Relationship of 2-(N-cyclicamino)chromone Derivatives2018
- Author(s)
  SHI HAIXIA、NAGAI JUNKO、SAKATSUME TSUKASA、BANDOW KENJIRO、OKUDAIRA NORIYUKI、SAKAGAMI HIROSHI、TOMOMURA MINEKO、TOMOMURA AKITO、UESAWA YOSHIHIRO、TAKAO KOICHI、SUGITA YOSHIAKI
- Journal Title
  
  Anticancer Res
  
  Volume: 38 Pages: 3897-3906
- DOI
  10.21873/anticanres.12674
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11487, KAKENHI-PROJECT-16K11519
[Journal Article] Quantitative Structure-Cytotoxicity Relationship of Furo[2,3-b]chromones2018
- Author(s)
  Uesawa Y, Sakagami H, Shi H, Hirose M, Takao K, Sugita Y
- Journal Title
  
  Anticancer Res
  
  Volume: 38(6) Pages: 3283-3290
- DOI
  10.21873/anticanres.12593
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11519
[Journal Article] Quantitative Structure-Cytotoxicity Relationship of Pyrano[4,3-b]chromones2018
- Author(s)
  NAGAI JUNKO、SHI HAIXIA、KUBOTA YUKA、BANDOW KENJIRO、OKUDAIRA NORIYUKI、UESAWA YOSHIHIRO、SAKAGAMI HIROSHI、TOMOMURA MINEKO、TOMOMURA AKITO、TAKAO KOICHI、SUGITA YOSHIAKI
- Journal Title
  
  Anticancer Res
  
  Volume: 38 Pages: 4449-4457
- DOI
  10.21873/anticanres.12747
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11487, KAKENHI-PROJECT-16K11519
[Journal Article] Quantitative Structure-Cytotoxicity Relationship of 3-(N-Cyclicamino)chromone Derivatives2018
- Author(s)
  SHI HAIXIA、NAGAI JUNKO、SAKATSUME TSUKASA、BANDOW KENJIRO、OKUDAIRA NORIYUKI、UESAWA YOSHIHIRO、SAKAGAMI HIROSHI、TOMOMURA MINEKO、TOMOMURA AKITO、TAKAO KOICHI、SUGITA YOSHIAKI
- Journal Title
  
  Anticancer Res
  
  Volume: 38 Pages: 4459-4467
- DOI
  10.21873/anticanres.12748
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11487, KAKENHI-PROJECT-16K11519
[Journal Article] Quantitative Structure?Cytotoxicity Relationship of 2-Azolylchromones2018
- Author(s)
  Sakagami H, Okudaira N, Uesawa Y, Takao K, Kagaya H, Sugita Y
- Journal Title
  
  Anticancer Research
  
  Volume: 38 Pages: 763-770
- DOI
  10.21873/anticanres.12282
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K11519, KAKENHI-PROJECT-15K08111
[Journal Article] Recent Progress of Basic Studies of Natural Products and Their Dental Application2018
- Author(s)
  Sakagami H, Watanabe T, Hoshino T, Suda N, Mori K, Yasui T, Yamauchi N, Kashiwagi H, Gomi T, Oizumi T, Nagai J, Uesawa Y, Takao K, Sugita Y.
- Journal Title
  
  Medicines
  
  Volume: 6 Pages: 4-4
- DOI
  10.3390/medicines6010004
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09843, KAKENHI-PROJECT-16K11519
[Journal Article] Quantitative Structure?Cytotoxicity Relationship of Cinnamic Acid Phenetyl Esters2018
- Author(s)
  Uesawa Y, Sakagami H, Okudaira N, Toda K, Takao K, Kagaya H and Sugita Y
- Journal Title
  
  Anticancer Research
  
  Volume: 38 Pages: 817-823
- DOI
  10.21873/anticanres.12289
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K11519, KAKENHI-PROJECT-15K08111
[Journal Article] Quantitative structure-cytotoxicity relationship of chalcones.2017
- Author(s)
  Sakagami H, Masuda Y,Tomomura M,Yokose S, Uesawa Y,Ikezoe N, Asahara D, Takao K, Kanamoto T, Terakubo S, Kagaya H, Nakashima H,and Sugita T.
- Journal Title
  
  Anticancer Research
  
  Volume: 37 Pages: 1091-1098
- DOI
  10.21873/anticanres.11421
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11487, KAKENHI-PROJECT-16K11519
[Journal Article] Quantitative Structure?Cytotoxicity Relationship of Aurones2017
- Author(s)
  Uesawa Y, Sakagami H, Ikezoe N, Takao K, Kagaya H and Sugita Y
- Journal Title
  
  Anticancer Research
  
  Volume: 37 Pages: 6169-6176
- DOI
  10.21873/anticanres.12066
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K11519, KAKENHI-PROJECT-15K08111
[Journal Article] Quantitative Structure-Cytotoxicity Relationship of Newly Synthesized Piperic Acid Esters2017
- Author(s)
  Sakagami H, Uesawa Y, Masuda Y, Tomomura M, Yokose S, Miyashiro T, Murai J, Takao K, Kanamoto T, Terakubo S, Kagaya H, Nakashima H, and Sugita Y.
- Journal Title
  
  Anticancer Res.
  
  Volume: 37 Pages: 6161-6168
- DOI
  10.21873/anticanres.12065
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K11487, KAKENHI-PROJECT-16K11519, KAKENHI-PROJECT-15K01319, KAKENHI-PROJECT-15K08111
[Journal Article] Search for New Type of Anticancer Drugs with High Tumor Specificity and Less Keratinocyte Toxicity2017
- Author(s)
  Sugita Y, Takao K, Uesawa Y and Sakagami H
- Journal Title
  
  Anticancer Research
  
  Volume: 37 Pages: 5919-5924
- DOI
  10.21873/anticanres.12038
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K11519, KAKENHI-PROJECT-15K08111
[Journal Article] Quantitative structure-cytotoxicity relationship of 3-benzylidenechromanones.2016
- Author(s)
  Uesawa Y, Sakagami H, Kagaya H, Yamashita M, Takao K, Sugita Y
- Journal Title
  
  Anticancer Research
  
  Volume: 36 Pages: 5803-5812
- DOI
  10.21873/anticanres.11164
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08111, KAKENHI-PROJECT-16K11519
[Journal Article] Induction of apoptotic cell death by putrescine2006
- Author(s)
  Takao, K.
- Journal Title
  
  Int. J. Biochem. Cell Biol. 38
  
  Pages: 621-628
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590033
[Presentation] ヒト口腔扁平上皮がん細胞に対する抗がん剤および過酸化水素とマイルドハイパーサーミアの併用効果2021
- Author(s)
  田川裕也、坂上宏、天野滋、友村美根子、坂東健二郎、高尾浩一、杉田義昭、植沢芳広、山本信治、坂下英明、中鍛治里奈、小泉敏之、光藤健司、藤内祝
- Organizer
  ハイパーサーミア学会
- Data Source
  KAKENHI-PROJECT-20H03893
[Presentation] ピラノ[4,3-b]クロモン誘導体の定量的構造‐細胞傷害性相関解析2018
- Author(s)
  永井純子、史海霞、久保田夕香、坂東健二郎、奥平准之、植沢芳広、坂上宏、友村美根子、友村明人、高尾浩一、杉田義昭
- Organizer
  第139回日本薬理学会関東部会、東京慈恵会医科大学、東京
- Data Source
  KAKENHI-PROJECT-16K11519
[Presentation] 2-(N-cyclicamino)chromone誘導体の定量的構造‐細胞傷害性相関解析2018
- Author(s)
  植沢芳広、史海霞、永井純子、坂詰つかさ、坂東健二郎、坂上宏、友村美根子、友村明人、高尾浩一、杉田義昭
- Organizer
  第139回日本薬理学会関東部会、東京慈恵会医科大学、東京
- Data Source
  KAKENHI-PROJECT-16K11519
[Presentation] 3-(N-サイクリックアミノ)クロモン誘導体の定量的構造‐細胞傷害性相関解析2018
- Author(s)
  坂上宏、史　海霞、永井純子、坂詰つかさ、坂東健二郎、奥平　准之、植沢芳広、友村美根子、友村明人、高尾浩一、杉田義昭
- Organizer
  第139回日本薬理学会関東部会、東京慈恵会医科大学、東京
- Data Source
  KAKENHI-PROJECT-16K11519
[Presentation] フラノクロモン誘導体の定量的構造‐細胞傷害性相関解析2017
- Author(s)
  植沢芳広、高尾浩一、杉田義、加賀谷肇、奥平准之、坂上宏
- Organizer
  第138回日本薬理学会関東部会、慶応義塾大学薬学部、東京
- Data Source
  KAKENHI-PROJECT-16K11519
[Presentation] オーロン誘導体の定量的構造‐細胞傷害性相関解析2017
- Author(s)
  植沢芳広、坂上宏、池添成彦、高尾浩一、加賀谷肇、杉田義昭
- Organizer
  第137回日本薬理学会関東部会、日本医科大学、東京
- Data Source
  KAKENHI-PROJECT-16K11519
[Presentation] ヒト肝がん由来細胞株HepG2に対する3-styrylchromone誘導体の抗腫瘍効果2017
- Author(s)
  内田知里、小澤知佳、菊地秀与、高尾浩一、杉田義昭、坂上宏、津田整、須永克佳
- Organizer
  日本薬学会第138年会、金沢
- Data Source
  KAKENHI-PROJECT-16K11519
[Presentation] ピペリン酸エステル誘導体の構造活性相関：腫瘍選択性とアポトーシス誘導2017
- Author(s)
  坂上宏、植沢芳広、増田宜子、友村美根子、金本大成、寺久保繁美、宮城昂幹、村井淳一、高尾浩一、横瀬敏志、加賀谷肇、中島秀喜、杉田義昭
- Organizer
  第137回日本薬理学会関東部会、日本医科大学、東京
- Data Source
  KAKENHI-PROJECT-16K11519
[Presentation] 3-Benzylidenechromanonesの定量的構造‐細胞傷害性相関解析2016
- Author(s)
  植沢芳広、坂上宏、山下毬藻、高尾浩一、杉田義昭
- Organizer
  第134回日本薬理学会関東部会
- Place of Presentation
  国際医療福祉大学薬学部、大田原市、栃木
- Data Source
  KAKENHI-PROJECT-16K11519

1. SUGITA Yoshiaki (20255029)

# of Collaborated Projects: 4 results

# of Collaborated Products: 27 results
2. Sakagami Hiroshi (50138484)

# of Collaborated Projects: 3 results

# of Collaborated Products: 27 results
3. OKUDIRA NORIYUKI (10635585)

# of Collaborated Projects: 3 results

# of Collaborated Products: 8 results
4. BANDOW KENJIRO (50347093)

# of Collaborated Projects: 3 results

# of Collaborated Products: 7 results
5. 植沢芳広 (90322528)

# of Collaborated Projects: 3 results

# of Collaborated Products: 22 results
6. 友村美根子 (30217559)

# of Collaborated Projects: 2 results

# of Collaborated Products: 10 results
7. 天野滋 (90167958)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
8. SHIRAHATA Akira (50150107)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. IKEGUCHI Yoshihiko (00364711)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. NAGAI JUNKO (50828142)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
11. 杉本昌弘 (30458963)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 須永克佳 (70236040)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
13. 田沼靖一 (10142449)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
14. 佐藤聡 (40530663)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 藤内祝 (50172127)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
16. 山本信治 (60385185)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
17. 光藤健司 (70303641)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
18. 小泉敏之 (80323575)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
19. 中鍛治里奈 (80845511)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
20. 坂下英明 (10178551)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
21. 植村武史 (50401005)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 小黒明広 (00292508)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 古地壯光 (00302167)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 友村明人

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
25. 加賀谷肇

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
26. 浅井大輔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
27. 中島秀喜

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
28. 須田直人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

takao koichi 高尾 浩一

高尾 浩一 タカオ コウイチ

TAKAO Koichi 高尾 浩一

Research Projects

Research Products

Co-Researchers

加齢によるスペルミン分解活性化機構解明と新規抗老化物質の創出

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of selective cytotoxicity against malignant cells by chromone derivatives

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of minimally invasive therapy for oral cancer by hyperthermia with tumor-specific targeting magnetic nanoparticles

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Basic study of the possibility of newly synthesized 3-styrylchromone derivatives as therapeutic drugs for oral cancer

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Proteome analysis as an index of conformational change of protein

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] A Dual Anti-Inflammatory and Anti-Proliferative 3-Styryl-chromone Derivative Synergistically Enhances the Anti-Cancer Effects of DNA-Damaging Agents on Colon Cancer Cells by Targeting HMGB1-RAGE-ERK1/2 Signaling2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A 3-styrylchromone converted from trimebutine 3D pharmacophore possesses dual suppressive effects on RAGE and TLR4 signaling pathways2021

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takao koichi 高尾浩一

高尾浩一タカオコウイチ

TAKAO Koichi 高尾浩一