SASAKI Takeshi 佐々木毅

Researcher Number	50110656
External Links
Affiliation (based on the past Project Information) *help	2006 – 2007: TOHOKU UNIVERSITY, Professor Emeritus, Professor 2005 – 2006: 東北大学, 大学院医学系研究科, 教授 1999 – 2005: 東北大学, 大学院・医学系研究科, 教授 2002: 東北大学, 医学系研究科, 教授 1993 – 1998: DEPARTMENT OF CLINICAL AND LABORATORY MEDICINE, TOHOKU UNIV.SCH.MED.PROFESSOR, 医学部, 教授 … More 1990 – 1992: 東北大学, 医学部, 助教授 1990 – 1991: 東北大学, 医学部附属病院, 助教授 1989: 東北大学, 医学部・附属病院, 講師 1989: 東北大学, 医学部附属病院, 講師 1988: Instructor, Tohoku University School of Medicine, 医学部付属病院, 講師 1987: 東北大, 医学部附属病院, 助手 1986: 東北大, 医学部, 助手 1985: 東北大学, 医, 助手 Less
Review Section/Research Field	Principal Investigator 内科学一般 / 膠原病・アレルギー・感染症内科学 / Laboratory medicine / Biological Sciences / Hematology / Laboratory medicine Except Principal Investigator Hematology / 内科学一般 / Public health/Health science / Immunology / Virology / Laboratory medicine / Hematology
Keywords	Principal Investigator ヒトパルボウイルスB19 / 抗DNA抗体 / anti-DNA antibody / TNFα / B19 / rheumatoid arthritis / 慢性関節リウマチ / SLE / siRNA / 全身性エリテマトーデス … More / マクロファージ / human parvovirus / 持続感染 / 自己抗体 / レセプター / Ku80 / 関節リウマチ / autoantibody / T cell clone / B cell clone / クローン / イディオタイプ / SLE(全身生エリテマトーデス) / 全身生エリテマトーデヌ / T細胞クローン / B細胞クローン / 全身性エリテユトーデス / B細胞クロン / T細胞クロン / 抗イディオタイプ抗体 / neutralizing antibody / KU80 / human parvovirus B19 / 低酸素 / P抗原 / T細胞 / si RNA / ウイルス中和抗体 / ヒトパルボウィルスB19 / 中和抗体 / ku80 / lupus nephritis / systemic lupus erythematosus / ループス腎炎 / adult T cell leukemia virus / retrovirus / antinucleic acid antibody / Gene therapy / V遺伝子 / ヒトT細胞白血病ウイルス / VH,VL / 人工単鎖抗体 / 成人型T細胞 / レトロウィルス / 成人型T細胞白血病ウイルス / レトロウイルス / 遺伝子治療 / 抗核酸抗体 / macrophage / human parvorirus B19 / Rheumatoid arthritis / リボザイム / ヒトパルボウイルス / arthritis / 関節炎 / persistent infection / 多発性関節炎 / Systemic Lupus Erythematosus / Immunoglobulin Gene / Anti-DNA Antibody / Autoantibody / In situ ハイブリダイゼ-ション / 抗DMA抗体 / V_H遺伝子 / 全身性エリテマト-デス / 免疫グロブリン遺伝子 / 膠原病 / リアルタイム測定 / 位相差トラッキングエコー / 超音波検査 / 強皮症 / 皮膚 / 位相差トラッキング法 / 造血幹細胞 / ScFv抗体 / CD34細胞 / 遺伝子導入 / PCR / 微少残存病変 / 腫瘍マーカー / 微量残存病変 / ELISA / 白血病 / スタニオカルシン / 免疫グロブリンプロモーター / B細胞 / VH遺伝子 / シトシンアラビノシド耐性 / シスプラチン耐性 / アンチセンスリボザイム … More Except Principal Investigator RNAi / delta-like 1 / bone marrow stromal cells / siRNA / DNA microarray / 骨髄間質細胞 / P53 / ELISA / 全身性エリテマトーデス / Dietary fiber / Vitamin B6 / Epidemiology / Prognosis / Cohort study / Educational level / Isoflavone / Systemic lupus erythematosus / 食物繊維 / ビタミンB6 / 疫学 / 予後 / コホート研究 / 学歴 / イソフラボン / erythropoiesis / heat shock protein / 赤芽球 / 骨髄 / 造血 / 赤芽球造血 / Tenascun-C / tenascin-C / DNAマイクロアレイ / Immunohistochemistory / Rheumatoid arthritis / p53 / 免疫組織化学 / 慢性関節リウマチ / Transplantation immunity / Monoclonal antibody / IL-2 receptor / Immune suppression / 増殖シグナル / IL-2 / 可溶化型 / γ鎖 / サイトカイン / 免疫制御 / 移植免疫 / 単クロン抗体 / IL-2受容体 / 免疫抑制 / immunofluorescence staining / polymerase chain reaction / Western blot / human parvovirus / アビジン・ビオチン / 蛍光抗体法 / ELISA法 / PCR / VPー1 / B19 / ヒトパルボウイルス / 血清診断 / 関節リウマチ / 非免疫性胎児水腫 / パルボウイルス / 免疫蛍光染色法 / 核酸重合反応法 / ウエスタンブロット法 / 免疫酵素法 / ヒト・パルボウイルス / 関節炎 / 発熱 / データベース / アンケート / 成人発症スティル病 / ディファレンシャル、ディスプレイ法 / T細胞 / 全身性エリテマトーデス(SLE) / V遺伝子 / 自己抗体 / ホローファイバー培養 / 高密度大量培養 / 骨髄細胞 Less

新規エコー法による強皮症病変の評価法の開発Principal Investigator
- Principal Investigator
  
  佐々木毅
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Laboratory medicine
- Research Institution
  Tohoku University
A cohort study of systemic lupus erythematosus for elucidating the association between intake of isoflavones and prognosis
- Principal Investigator
  
  MINAMI Yuko
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Public health/Health science
- Research Institution
  Tohoku University
Identification of molecules determining the stromal-cell dependent hematopoiesis
- Principal Investigator
  
  KAMEOKA Junichi
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Tohoku University
Mechanism for human parvovirus B19-induced rheumatoid arthjritisPrincipal Investigator
- Principal Investigator
  
  SASAKI Takeshi
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  TOHOKU UNIVERSITY
関節リウマチ発症におけるヒトパルボウイルスB19に関する研究Principal Investigator
- Principal Investigator
  
  佐々木毅
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
Identification of molecules determining the stromal-cell dependent hematopoiesis
- Principal Investigator
  
  KAMEOKA Junichi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  TOHOKU UNIVERSITY
成人発症スティル病の診断・治療・予後に関する集学的研究
- Principal Investigator
  
  江口勝美
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  内科学一般
- Research Institution
  Nagasaki University
抗DNA抗体を用いたCD34陽性細胞への遺伝子導入Principal Investigator
- Principal Investigator
  
  佐々木毅
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Hematology
- Research Institution
  Tohoku University
Etiological agents responsible for systemic lupus erythrmatosusPrincipal Investigator
- Principal Investigator
  
  SASAKI Takeshi
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  内科学一般
- Research Institution
  Tohoku University
Antinucleic aid antibody gene therapy for rheumatoid Arthritis and adult T cell LeukemiaPrincipal Investigator
- Principal Investigator
  
  SASAKI Takeshi
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  内科学一般
- Research Institution
  Tohoku University
腫瘍マーカーとしてのカルシウム調節ホルモン・スタニオカルシンPrincipal Investigator
- Principal Investigator
  
  佐々木毅
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Laboratory medicine
- Research Institution
  Tohoku University
Approarch for the viral agent responsible for rheumatoid arthritisPrincipal Investigator
- Principal Investigator
  
  SASAKI Takeshi
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  内科学一般
- Research Institution
  Tohoku University
全身性エリテマトーデスの予知的指標としての特異的遺伝子Principal Investigator
- Principal Investigator
  
  佐々木毅, ISHII Tomonori
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Laboratory medicine
- Research Institution
  Tohoku University
組織特異的に発現するアンチセンスリボザイムによる治療Principal Investigator
- Principal Investigator
  
  佐々木毅
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tohoku University
Research for human parvovirus and rheumatoid arthritis.Principal Investigator
- Principal Investigator
  
  SASAKI Takeshi
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  内科学一般
- Research Institution
  Tohoku University
Tumor inhibitory gene in rheumatoid arthritis
- Principal Investigator
  
  SHIBATA Shinobu, 高橋裕一
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  内科学一般
- Research Institution
  Tohoku University
骨髄細胞の高密度大量培養に関する研究
- Principal Investigator
  
  ENDO Kazuyasu
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Tohoku University
Development of immunosuppressant drugs based on inhibition of IL-2 function
- Principal Investigator
  
  SUGAMURA Kazuo
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  Immunology
- Research Institution
  TOHOKU UNIVERSITY
The role of human parvovirus infection in rheumatoid arthritisPrincipal Investigator
- Principal Investigator
  
  SASAKI Takeshi
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  内科学一般
- Research Institution
  TOHOKU UNIVERSITY
The Analysis for Human Autoantibody Producing System using Biotechnology.Principal Investigator
- Principal Investigator
  
  SASAKI Takeshi
- Project Period (FY)
  1989 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  内科学一般
- Research Institution
  Tohoku University
Development of diagnostic methods for human parvovirus infection
- Principal Investigator
  
  SUGAMURA Kazuo
- Project Period (FY)
  1989 – 1991
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research
- Research Field
  
  Virology
- Research Institution
  Tohoku Univeristy
Analysis of regulatory mechanism for autoantibody production by using human T and B cell clones.Principal Investigator
- Principal Investigator
  
  SASAKI Takeshi
- Project Period (FY)
  1986 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  内科学一般
- Research Institution
  TOHOKU UNIVERSITY
Specific elimination of anti-DNA antibody-producing cells in systemic lupus erythematosus.Principal Investigator
- Principal Investigator
  
  SASAKI Takeshi
- Project Period (FY)
  1984 – 1985
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research
- Research Field
  
  内科学一般
- Research Institution
  Tohoku University

All 2006 2000

All Journal Article

[Journal Article] Identification of Tenascin-C as a Key Molecule Determining the Stromal Cell -Dependent Erythropoiesis2006
- Author(s)
  Masanori Seki, Junichi Kameoka, Shinichiro Takahashi, Hideo Harigae, Nobuaki Yanai, Masuo Obinata, Takeshi Sasaki
- Journal Title
  
  Experimental Hematology (in press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590992
[Journal Article] Anti-K-ras rybozyme induced a growth inhibition and an increaseα chemosensitivity of human colon cancer cells.2000
- Author(s)
  Funato, T., Sasaki, T., et al.
- Journal Title
  
  Cancer Gene Therapy 165
  
  Pages: 495-500
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-10307012
[Journal Article] In vitro leukemia cell models of Ara-C resistance.2000
- Author(s)
  T.Funato, J.Satou, Y.Nishiyama, S.Fujimaki, T.Miura, M.Kaku, T.Sasaki.
- Journal Title
  
  Leukemia Research 24
  
  Pages: 535-541
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-10307012
[Journal Article] Chemically modified ribozyme to V gene inhibits anti-DNA production and the formation of immune deposits caused by lupus lymphocytes.2000
- Author(s)
  Suzuki, Y., Sasaki, T., et al.
- Journal Title
  
  J.Immunol. 165
  
  Pages: 5900-5905
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-10307012
[Journal Article] Cloning of a coproporphyrinogen oxidase promoter regulatory element binding protein.2000
- Author(s)
  Takahashi, S, Sasaki, T., et al.
- Journal Title
  
  Biochem.Biophy.Res.Com. 273
  
  Pages: 596-602
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-10307012
[Journal Article] Chemically modified ribozyme to V gene inhibits anti-DNA production and the formation of immune deposits caused by lupus lymphocytes.2000
- Author(s)
  Y.Suzuki, T.Funato, Y.Munakata, K.Sato, Y.Hirabayashi, T.Ishii, N.Takasawa, T.Ootaka, T.Saito, T.Sasaki.
- Journal Title
  
  J Immunol 165
  
  Pages: 5900-5905
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-10307012
[Journal Article] In vitro leukemia cell models of Ara-C resistance.2000
- Author(s)
  Funato, T., Sasaki, T., et al.
- Journal Title
  
  Leukemia Research 24
  
  Pages: 535-541
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-10307012
[Journal Article] Cloning of a coproporphyrinogen oxidase promoter regulatory element binding protein.2000
- Author(s)
  S.Takahashi, K.Furuyama, A.Kobayashi, S.Taketani, H.Harigae, M.Yamamoto, K.Igarashi, T.Sasaki, N.Hayashi
- Journal Title
  
  Biochem biophys Res Commun 273
  
  Pages: 596-602
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-10307012
[Journal Article] Anti-K-ras rybozyme induces a growth inhibition and an increased chemosensitivity of human colon cancer cells.2000
- Author(s)
  T.Funato, T.Ishii, M.Kambe, K.J.Scanlon, T.Sasaki.
- Journal Title
  
  Cancer Gene Therapy 7
  
  Pages: 495-500
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-10307012

1. KAMEOKA Junichi (30261621)

# of Collaborated Projects: 6 results

# of Collaborated Products: 1 results
2. SHIBATA Shinobu (00271932)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
3. ISHII Tomonori (10282138)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
4. HARIGAE Hideo (50302146)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
5. MUNAKATA Yasuhiko (20271950)

# of Collaborated Projects: 5 results

# of Collaborated Products: 1 results
6. FUNATO Tadao (70165455)

# of Collaborated Projects: 4 results

# of Collaborated Products: 5 results
7. ENDO Kazuyasu (60125507)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
8. SUGAMURA Kazuo (20117360)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
9. ISHII Keiko (00291253)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
10. TAKAHASHI Yuichi (80261535)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. SANO Hiroshi (20178809)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. OKAMURA Kunihiro (90124560)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. NAKAMURA Masataka (30180392)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. SATOMI Susumu (00154120)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. ASAO Hironobu (80250744)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. ISHIOKA Chikashi (60241577)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. KITAGAWA Yoshichika (10006752)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. TAKAHASHI Shinichiro (40375069)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. MINAMI Yuko (60239316)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 星野淳 (60241600)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 無量井泰 (00241638)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 江口勝美 (30128160)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 竹内勤 (50179610)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 小池隆夫 (80146795)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 長澤浩平 (00108721)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 宮坂信之 (30157622)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 宮村耕一 (70323029)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. 八重樫伸生 (00241597)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. 仁木賢 (60241626)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. SHIRAISHI Hiroyuki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

SASAKI Takeshi 佐々木 毅

Research Projects

Research Products

Co-Researchers

新規エコー法による強皮症病変の評価法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

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Research Institution

Principal Investigator

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Mechanism for human parvovirus B19-induced rheumatoid arthjritisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

関節リウマチ発症におけるヒトパルボウイルスB19に関する研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

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Principal Investigator

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Research Institution

抗DNA抗体を用いたCD34陽性細胞への遺伝子導入Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Etiological agents responsible for systemic lupus erythrmatosusPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Antinucleic aid antibody gene therapy for rheumatoid Arthritis and adult T cell LeukemiaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

腫瘍マーカーとしてのカルシウム調節ホルモン・スタニオカルシンPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Approarch for the viral agent responsible for rheumatoid arthritisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

全身性エリテマトーデスの予知的指標としての特異的遺伝子Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

組織特異的に発現するアンチセンスリボザイムによる治療Principal Investigator

Principal Investigator

SASAKI Takeshi 佐々木毅