• Search Research Projects
  • Search Researchers
  1. Back to previous page

GOTO Sinji  後藤 信治

ORCIDConnect your ORCID iD *help
Researcher Number 50186889
Other IDs
External Links
Affiliation *help 2013 – 2017 : 長崎大学, 原爆後障害医療研究所, 助教
2013 : 長崎大学, 医歯(薬)学総合研究科, 助教
2007 : 長崎大学, 原爆後障害医療研究所, 助教
2004 – 2005 : 長崎大, 医歯(薬)学総合研究科, 助手
2003 – 2005 : Nagasaki University, Graduate School of Biomedical Sciences, Research Associate, 大学院・医歯薬学総合研究科, 助手 … More
2002 – 2003 : 長崎大, 医学部, 助手
2000 – 2002 : 長崎大学, 医学部, 助手
1996 : 長崎大, 医学部, 助手
1996 : 長崎大学, 医学部, 助手
1991 – 1994 : 長崎大学, 医学部, 助手 Less
Review Section/Research Field
Principal Investigator
Digestive surgery / Pathological medical chemistry / Pathological medical chemistry / Respiratory organ internal medicine / General medical chemistry
Except Principal Investigator
Radiation science / Risk sciences of radiation/Chemicals / 代謝生物化学 / Pathological medical chemistry
Keywords
Principal Investigator
glutathione S-transferase π / cisplatin / シスプラチン / cancer / nuclear translocation / 薬剤耐性 / グルタチオン / anti-cancer drug resistance / 癌 / nucleus … More / drug resistance / doxorubicin / oxidative stress / exocyclic DNA adducts / glutathione S-transferaseπ / 抗がん剤耐性 / 核局在 / 大腸がん / doxoruvicin / 解糖系 / グルコース飢餓 / CD133 / glutathione S-transferasen / 栄養飢餓耐性 / 好中球由来エラスターゼ / がん幹細胞 / alpha_1-アンチトリプシン / 酵素 / nuclear localization signal / apoptosis / グルタチオン S-トランスフェラーゼπ / GSTπ / 慢性肺気腫 / deug resistance / がん幹細胞マーカー / mitochondria import signal / グルタチオンS-トランスフェラーゼ / mitochondria / 代謝 / マンノース-6-リン酸 … More
Except Principal Investigator
γ-GCS / GST / RZR / activator protein-1 / VEGF / ROR / Akt / p53 / 2 / ERK1 / PCR-amplification / 前転移ニッチ / エピトープ / 原発性胆汁性肝硬変症 / PCR増幅 / 心臓幹細胞 / Deficiency / 発現調節 / 放射線傷害 / ジヒドロリポアミドアセチル転移酵素 / グルタチオン / ELISA / 自己抗原 / 欠損症 / Point mutation / 非がん疾患リスク / 遺伝子 / 幹細胞 / Pyruvate dehydrogenase / 変異(欠損症)遺伝子 / 点変異 / 放射線治療 / ピルビン酸脱水素酵素 / Gene / Expression / 放射線 / ヒトピルビン酸脱水素酵素 / 癌転移 / βーサブユニット遺伝子 / メラトニン / 血管内皮増殖因子 / αーサブユニット遺伝子 / 再生修復機能 / 自己免疫疾患 / α,βサブユニット / 心筋幹細胞 / alpha and beta subunits Less
  • Research Projects

    (13results)
  • Research Products

    (20results)
  • Co-Researchers

    (10People)
  •  放射線治療副作用の軽減とがん転移の抑制を両立する治療薬の開発Ongoing

    • Principal Investigator
      李 桃生
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Radiation science
    • Research Institution
      Nagasaki University
  •  がん幹細胞の代謝特性を標的とした新規がん治療法の開発Principal InvestigatorOngoing

    • Principal Investigator
      後藤 信治
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Digestive surgery
    • Research Institution
      Nagasaki University
  •  Radiation-induced injury in tissue-specific stem cells for evaluating non-cancer disease risks

    • Principal Investigator
      LI Tao-Sheng
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Radiation science
    • Research Institution
      Nagasaki University
  •  The explore of new cancer stem cell marker based on intracellular behavior of biological defense factorPrincipal Investigator

    • Principal Investigator
      GOTO Shinji
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Nagasaki University
  •  Molecular mechanism of intracellular localization of glutathione S-transferase πPrincipal Investigator

    • Principal Investigator
      GOTO Shinji
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Nagasaki University
  •  Effect of nuclear glutathione on DNA damage by irradiation

    • Principal Investigator
      URATA Yoshishige
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Risk sciences of radiation/Chemicals
    • Research Institution
      Nagasaki University
  •  Basic Research of Novel Molecular Target on Cancer ChemotherapyPrincipal Investigator

    • Principal Investigator
      GOTO Shinji
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Nagasaki University
  •  The effect of melatonin on the cell proliferation

    • Principal Investigator
      URATA Yoshishige
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Nagasaki University
  •  細胞におけるグルタチオン-シスプラチン結合体の形成と排出機構の解明Principal Investigator

    • Principal Investigator
      後藤 信治
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Nagasaki University
  •  ガン細胞のシスプラチン耐性獲得機構の解明Principal Investigator

    • Principal Investigator
      後藤 信治
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      General medical chemistry
    • Research Institution
      Nagasaki University
  •  慢性肺気腫の膜受容体を介した新しい治療法の開発Principal Investigator

    • Principal Investigator
      後藤 信治
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      Nagasaki University
  •  原発性胆汁性肝硬変症の自己抗原のエピトープ解析と臨床応用

    • Principal Investigator
      URATA Yosisige
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Institution
      Nagasaki University
  •  Pyruvate Dehydrogenase Gene: Regulation of its Expression and Identification of Mutation in the PCR-amplified Exon Segments from the Patient with Fatal Deficiency

    • Principal Investigator
      KOIKE Kichiko
    • Project Period (FY)
      1991 – 1992
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      代謝生物化学
    • Research Institution
      Nagasaki University

All 2017 2016 2015 2014 2013 2005 2004 Other

All Journal Article Presentation

  • [Journal Article] Ionizing radiation impairs endogenous regeneration of infarcted heart: an in vivo 18F-FDG PET/CT and 99mTc-tetrofosmin SPECT/CT study in mice.2017

    • Author(s)
      Luo L, Nishi K, Urata Y, Yan C, Hasan AS, Goto S, Kudo T, Li ZL, Li TS
    • Journal Title

      Radiation Research

      Volume : 187 Pages : 89-97

    • Peer Reviewed / Open Access / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H02654, KAKENHI-PROJECT-26293279
  • [Journal Article] Dose-dependency and reversibility of radiation-induced injury in cardiac explant-derived cells of mice2017

    • Author(s)
      Luo L, Yan C, Urata Y, Hasan AS, Goto S, Guo CY, Zhang S, Li TS
    • Journal Title

      Scientific Reports

      Volume : 7 Pages : 40959

    • Publisher
      Macmillan Publishers Limited
    • Year and Date
      2017-01-18
    • Language
      English
    • Peer Reviewed / Open Access / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15H02654, KAKENHI-PROJECT-26293279
  • [Journal Article] Enhanced autophagy in colorectal cancer stem cells does not contribute to radio-resistance2016

    • Author(s)
      Chen Yan, Lan Luo, Shinji Goto, Yoshishige Urata, Chang-Ying Guo, Hanako Doi, Kaio Kitazato, Tao-Sheng Li
    • Journal Title

      Oncotarget

      Volume : 印刷中 Pages : 45112-45121

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25462061, KAKENHI-PROJECT-15H02654
  • [Journal Article] Radiation exposure decreases the quantity and quality of cardiac stem cells in mice.2016

    • Author(s)
      Luo L, Urata Y, Yan C, Hasan AS, Goto S, Guo CY, Tou FF, Xie Y, Li TS.
    • Journal Title

      PLoS ONE

      Volume : 印刷中

    • Open Access / Int'l Joint Research / Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26293279
  • [Journal Article] Time‐ and dose‐dependent effects of total‐body ionizing radiation on muscle stem cells2015

    • Author(s)
      Masuda S, Hisamatsu T, Seko S, Urata Y, Goto S, Li TS & Ono Y
    • Journal Title

      Physiological Reports

      Volume : 3 Issue : 4 Pages : e12377

    • Publisher
      American Physiological Society and The Physiological Society
    • Year and Date
      2015-04-13
    • Language
      English
    • Peer Reviewed / Open Access / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25560338, KAKENHI-PROJECT-15K15509, KAKENHI-PROJECT-26293279, KAKENHI-PROJECT-15H02654
  • [Journal Article] Sensitivity and dose dependency of radiation-induced injury in hematopoietic stem/progenitor cells in mice2015

    • Author(s)
      Chang-Ying Guo, Lan Luo, Yoshishige Urata, Shinji Goto, Wen-Jing Huang, Syu Takamura, Fumiko Hayashi, Hanako Doi, Yuriko Kitajima, Yusuke Ono, Tomoo Ogi, and Tao-Sheng Li
    • Journal Title

      Scientific Reports

      Volume : 5 Pages : 8055

    • Publisher
      Nature Publishing Group
    • Year and Date
      2015-01-27
    • Language
      English
    • Peer Reviewed / Open Access / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25750154, KAKENHI-PROJECT-26293279
  • [Journal Article] The potential benefits of nicaraven to protect against radiation-induced injury in hematopoietic stem/progenitor cells with relative low dose exposures2014

    • Author(s)
      Ali H, Galal O, Urata Y, Goto S, Guo CY, Luo L, Abdelrahim E, Ono Y, Mostafa E, Li TS.
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume : 452 Issue : 3 Pages : 548-553

    • Publisher
      Academic Press Inc.
    • Year and Date
      2014-09-26
    • Language
      English
    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26293279
  • [Journal Article] Nicaraven Attenuates Radiation-Induced Injury in Hematopoietic Stem/Progenitor Cells in Mice2013

    • Author(s)
      Kawakatsu M, Urata Y, Imai R, Goto S, Ono Y, Nishida N, Li TS
    • Journal Title

      PLoS ONE

      Volume : 8 Issue : 3 Pages : e60023

    • Publisher
      Public Library of Science
    • Year and Date
      2013-03-29
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25462061
  • [Journal Article] Placental extract protects bone marrow-derived stem/progenitor cells against radiation injury through anti-inflammatory activity2013

    • Author(s)
      Kawakatsu M, Urata Y, Goto S, Ono Y, Li TS
    • Journal Title

      Journal of Radiation Research

      Volume : 54 Issue : 2 Pages : 268-276

    • Publisher
      日本放射線影響学会
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25462061, KAKENHI-PROJECT-24800051
  • [Journal Article] Nuclear Localization of Glutathione S-Transferase π is an Evaluation Factor for Drug Resistance in Gynecological Cancers.2005

    • Author(s)
      Soh, Y., Goto, S., et al.
    • Journal Title

      Clinical Oncology 17(4)

      Pages : 264-270

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16590247
  • [Journal Article] Nuclear Localization of Glutathione S-Transferase π is an Evaluation Factor for Drug Resistance in Gynecological Cancers.2005

    • Author(s)
      Soh, Y., Goto, S., Kitajima, M., Moriyama, S., Kotera, K., Nakayama, T., Nakajima, H., Kondo, T., Ishimaru, T.
    • Journal Title

      Clinical Oncology, 17(4)

      Pages : 264-270

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590247
  • [Journal Article] Nuclear Localization of Glutathione S-Transferase π is an Evaluation Factor for Drug Resistance in Gynecological Cancers.2005

    • Author(s)
      Soh, Y., Goto, S., et al.
    • Journal Title

      Clinical Oncology (in press)

    • Data Source
      KAKENHI-PROJECT-16590247
  • [Journal Article] Nuclear glutathione S-transferase p prevents apoptosis by reducing the oxidative stress-induced formation of exocyclic DNA adducts.2004

    • Author(s)
      Kamada, K., Goto, S., Okunaga, T., Ihara, Y., Tsuji, K., Kawai, Y., Uchida, K., Osawa, T., Matsuo, T., Nagata, I., Kondo, T.
    • Journal Title

      Free Radical.Biol.Med., 37(11)

      Pages : 1875-1884

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590247
  • [Journal Article] Nuc1ear glutathione S-transferase π prevents apoptosis by reducing the oxidative stress-induced formation of exocyclic DNA adducts.2004

    • Author(s)
      Kamada, K., Goto, S., et al.
    • Journal Title

      Free Radical. Biol. Med. 37(11)

      Pages : 1875-1884

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16590247
  • [Journal Article] Nuclear glutathione S-transferase π prevents apoptosis by reducing the oxidative stress-induced formation of exocyclic DNA adducts.2004

    • Author(s)
      Kamada, K., Goto, S., et al.
    • Journal Title

      Free Radical.Biol.Med. 37(11)

      Pages : 1875-1884

    • Data Source
      KAKENHI-PROJECT-16590247
  • [Presentation] Radiation-induced damages on cardiac stem cells and myocardial regeneration may indirectly indicate future cardiovascular disease risks2016

    • Author(s)
      Lan Luo1, Kodai Nishi2, Yoshishige Urata, Chen Yan, Shinji Goto, Takashi Kudo, Tao-Sheng Li
    • Organizer
      日本放射線影響学会第59回大会
    • Place of Presentation
      JMSアステールプラザ(広島県・広島市)
    • Year and Date
      2016-10-26
    • Data Source
      KAKENHI-PROJECT-26293279
  • [Presentation] 放射線被ばくによる心血管疾患リスクに関する実験的科学評価2015

    • Author(s)
      羅蘭、浦田芳重、後藤信治、小野悠介、李桃生
    • Organizer
      第56回原子爆弾後障害研究会
    • Place of Presentation
      広島国際会議場
    • Year and Date
      2015-06-06
    • Data Source
      KAKENHI-PROJECT-26293279
  • [Presentation] Radiation-induced damage of cardiac stem cells in quantity and quality2015

    • Author(s)
      Lan Luo, Yoshishige Urata, Shinji Goto, Yusuke Ono, Tao-Sheng Li
    • Organizer
      ICRR2015 Kyoto Japan - 15th International Congress of Radiation Research
    • Place of Presentation
      京都府京都市国際会議場
    • Year and Date
      2015-05-25
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26293279
  • [Presentation] The mechanism of drug resistance of CD133-expressed cancer cell2015

    • Author(s)
      後藤信治、浦田芳重、小野悠介、李桃生
    • Organizer
      日本生化学会
    • Place of Presentation
      神戸国際会議場(神戸市、兵庫県)
    • Year and Date
      2015-12-01
    • Data Source
      KAKENHI-PROJECT-25462061
  • [Presentation] Radiation-induced damage of cardiac stem cells in quantity and quality

    • Author(s)
      Lan Luo, Yoshishige Urata, Shinji Goto, Yusuke Ono, Tao-Sheng Li
    • Organizer
      ICRR2015
    • Place of Presentation
      京都国際会館
    • Year and Date
      2015-05-25 – 2015-05-29
    • Data Source
      KAKENHI-PROJECT-26293279
  • 1.  URATA Yosisige (30185087)
    # of Collaborated Projects : 6results
    # of Collaborated Products : 10results
  • 2.  KONDO Takahito (00158908)
    # of Collaborated Projects : 4results
    # of Collaborated Products : 2results
  • 3.  IHARA Yoshito (70263241)
    # of Collaborated Projects : 4results
    # of Collaborated Products : 1results
  • 4.  LI Taosheng (50379997)
    # of Collaborated Projects : 3results
    # of Collaborated Products : 14results
  • 5.  KAWAKATSU Miho (20398150)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 2results
  • 6.  KOIKE Kichiko (80039619)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 0results
  • 7.  小池 吉子 (10039521)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 0results
  • 8.  工藤 崇 (20330300)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 2results
  • 9.  小野 悠介 (60601119)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 6results
  • 10.  HUANG Wenjing
    # of Collaborated Projects : 0results
    # of Collaborated Products : 1results

URL :

Are you sure that you want to connect your ORCID iD to this researcher?

Information FAQ News Terms of Use

Powered by NII kakenhi