GOTO Sinji 後藤信治

Researcher Number	50186889
Other IDs
External Links
Affiliation *help	2013 – 2018 : 長崎大学, 原爆後障害医療研究所, 助教 2003 – 2005 : Nagasaki University, Graduate School of Biomedical Sciences, Research Associate, 大学院・医歯薬学総合研究科, 助手 2000 – 2002 : 長崎大学, 医学部, 助手 1996 : 長崎大学, 医学部, 助手 1991 – 1994 : 長崎大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Pathological medical chemistry / Digestive surgery / Pathological medical chemistry / Respiratory organ internal medicine / General medical chemistry Except Principal Investigator Radiation science / Risk sciences of radiation/Chemicals / 代謝生物化学 / Pathological medical chemistry
Keywords	Principal Investigator glutathione S-transferase π / cisplatin / シスプラチン / cancer / nuclear translocation / 薬剤耐性 / グルタチオン / anti-cancer drug resistance / 癌 / nucleus … More Except Principal Investigator γ-GCS / GST / RZR / activator protein-1 / VEGF / ROR / Akt / p53 / 2 / ERK1 / PCR-amplification / 前転移ニッチ / エピトープ / 原発性胆汁性肝硬変症 / PCR増幅 / 心臓幹細胞 / Deficiency / 発現調節 / 放射線傷害 / ジヒドロリポアミドアセチル転移酵素 / グルタチオン / ELISA / 自己抗原 / 欠損症 / Point mutation / 非がん疾患リスク / 遺伝子 / 幹細胞 / Pyruvate dehydrogenase / 変異(欠損症)遺伝子 / 点変異 / 放射線治療 / ピルビン酸脱水素酵素 / Gene / Expression / 放射線 / ヒトピルビン酸脱水素酵素 / 癌転移 / βーサブユニット遺伝子 / メラトニン / 血管内皮増殖因子 / αーサブユニット遺伝子 / 再生修復機能 / 自己免疫疾患 / α,βサブユニット / 心筋幹細胞 / alpha and beta subunits Less

放射線治療副作用の軽減とがん転移の抑制を両立する治療薬の開発Ongoing
- Principal Investigator
  
  李桃生
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Radiation science
- Research Institution
  Nagasaki University
がん幹細胞の代謝特性を標的とした新規がん治療法の開発Principal InvestigatorOngoing
- Principal Investigator
  
  後藤信治
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Digestive surgery
- Research Institution
  Nagasaki University
Radiation-induced injury in tissue-specific stem cells for evaluating non-cancer disease risks
- Principal Investigator
  
  LI Tao-Sheng
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Radiation science
- Research Institution
  Nagasaki University
The explore of new cancer stem cell marker based on intracellular behavior of biological defense factorPrincipal Investigator
- Principal Investigator
  
  GOTO Shinji
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Nagasaki University
Molecular mechanism of intracellular localization of glutathione S-transferase πPrincipal Investigator
- Principal Investigator
  
  GOTO Shinji
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Nagasaki University
Effect of nuclear glutathione on DNA damage by irradiation
- Principal Investigator
  
  URATA Yoshishige
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Risk sciences of radiation/Chemicals
- Research Institution
  Nagasaki University
Basic Research of Novel Molecular Target on Cancer ChemotherapyPrincipal Investigator
- Principal Investigator
  
  GOTO Shinji
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Nagasaki University
The effect of melatonin on the cell proliferation
- Principal Investigator
  
  URATA Yoshishige
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Nagasaki University
細胞におけるグルタチオン-シスプラチン結合体の形成と排出機構の解明Principal Investigator
- Principal Investigator
  
  後藤信治
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Nagasaki University
ガン細胞のシスプラチン耐性獲得機構の解明Principal Investigator
- Principal Investigator
  
  後藤信治
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  General medical chemistry
- Research Institution
  Nagasaki University
慢性肺気腫の膜受容体を介した新しい治療法の開発Principal Investigator
- Principal Investigator
  
  後藤信治
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Nagasaki University
原発性胆汁性肝硬変症の自己抗原のエピトープ解析と臨床応用
- Principal Investigator
  
  URATA Yosisige
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Institution
  Nagasaki University
Pyruvate Dehydrogenase Gene: Regulation of its Expression and Identification of Mutation in the PCR-amplified Exon Segments from the Patient with Fatal Deficiency
- Principal Investigator
  
  KOIKE Kichiko
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  代謝生物化学
- Research Institution
  Nagasaki University

All 2017 2016 2015 2014 2013 2005 2004 Other

All Journal Article Presentation

[Journal Article] Ionizing Radiation Impairs Endogenous Regeneration of Infarcted Heart: An In Vivo 18F-FDG PET/CT and 99mTc-Tetrofosmin SPECT/CT Study in Mice.2017
- Author(s)
  Luo L, Nishi K, Urata Y, Yan C, Hasan AS, Goto S, Kudo T, Li ZL, Li TS
- Journal Title
  
  Radiat Res.
  
  Volume : 187 Pages : 89-97
- DOI
  10.1667/RR14543.1
- Peer Reviewed / Int'l Joint Research / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H02654, KAKENHI-PROJECT-26293279
[Journal Article] Dose-dependency and reversibility of radiation-induced injury in cardiac explant-derived cells of mice.2017
- Author(s)
  Luo L, Yan C, Urata Y, Hasan AS, Goto S, Guo CY, Zhang S, Li TS
- Journal Title
  
  Scientific Reports
  
  Volume : 7 Pages : 40959
- Publisher
  Macmillan Publishers Limited
- DOI
  10.1038/srep40959
- Year and Date
  2017-01-18
- Language
  English
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H02654, KAKENHI-PROJECT-26293279
[Journal Article] Radiation exposure decreases the quantity and quality of cardiac stem cells in mice.2016
- Author(s)
  Luo L, Urata Y, Yan C, Hasan AS, Goto S, Guo CY, Tou FF, Xie Y, Li TS.
- Journal Title
  
  PLoS ONE
  
  Volume : 印刷中
- Open Access / Int'l Joint Research / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26293279
[Journal Article] Enhanced autophagy in colorectal cancer stem cells does not contribute to radio-resistance.2016
- Author(s)
  Chen Yan, Lan Luo, Shinji Goto, Yoshishige Urata, Chang-Ying Guo, Hanako Doi, Kaio Kitazato, Tao-Sheng Li
- Journal Title
  
  Oncotarget
  
  Volume : 印刷中 Pages : 45112-45121
- DOI
  10.18632/oncotarget.8972
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25462061, KAKENHI-PROJECT-15H02654
[Journal Article] Time- and dose-dependent effects of total-body ionising radiation on muscle stem cells2015
- Author(s)
  Masuda S, Hisamatsu T, Seko S, Urata Y, Goto S, Li TS & Ono Y
- Journal Title
  
  Physiol Rep
  
  Volume : 3 Issue : 4 Pages : e12377
- Publisher
  American Physiological Society and The Physiological Society
- DOI
  10.14814/phy2.12377
- Year and Date
  2015-04-13
- Language
  English
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25560338, KAKENHI-PROJECT-15K15509, KAKENHI-PROJECT-26293279, KAKENHI-PROJECT-15H02654
[Journal Article] Sensitivity and Dose Denpendency of Radiation-induced injury in hematopoietic Stem/Progenitor Cells in Mice2015
- Author(s)
  Chang-Ying Guo, Lan Luo, Yoshishige Urata, Shinji Goto, Wen-Jing Huang, Syu Takamura, Fumiko Hayashi, Hanako Doi, Yuriko Kitajima, Yusuke Ono, Tomoo Ogi, and Tao-Sheng Li
- Journal Title
  
  Sci. Rep.
  
  Volume : 5 Pages : 8055
- Publisher
  Nature Publishing Group
- DOI
  10.1038/srep08055
- Year and Date
  2015-01-27
- Language
  English
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25750154, KAKENHI-PROJECT-26293279
[Journal Article] S100A4 is frequently overexpressed in lung cancer cells and promotes cell growth and cell motility.2014
- Author(s)
  Chen N, Sato D, Saiki Y, Sunamura M, Fukushige S, Horii A
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume : 452 Issue : 3 Pages : 548-553
- Publisher
  Academic Press Inc.
- DOI
  10.1016/j.bbrc.2014.08.112
- Year and Date
  2014-09-26
- Language
  English
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25462673, KAKENHI-PROJECT-26293279
[Journal Article] Nicaraven attenuates radiation-induced injury in hematopoietic stem/progenitor cells in mice2013
- Author(s)
  Kawakatsu M, Urata Y, Imai R, Goto S, Ono Y, Nishida N, Li TS
- Journal Title
  
  PLoS One
  
  Volume : 8 Issue : 3 Pages : e60023
- Publisher
  Public Library of Science
- DOI
  10.1371/journal.pone.0060023
- Year and Date
  2013-03-29
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25462061
[Journal Article] Placental extract protects bone marrow-derived stem/progenitor cells against radiation injury through anti-inflammatory activity2013
- Author(s)
  Kawakatsu M, Urata Y, Goto S, Ono Y, Li TS
- Journal Title
  
  Journal of Radiation Research
  
  Volume : 54 Issue : 2 Pages : 268-276
- Publisher
  日本放射線影響学会
- DOI
  10.1093/jrr/rrs105
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25462061, KAKENHI-PROJECT-24800051
[Journal Article] Nuclear Localization of Glutathione S-Transferase π is an Evaluation Factor for Drug Resistance in Gynecological Cancers.2005
- Author(s)
  Soh, Y., Goto, S., et al.
- Journal Title
  
  Clinical Oncology 17(4)
  
  Pages : 264-270
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590247
[Journal Article] Nuclear Localization of Glutathione S-Transferase π is an Evaluation Factor for Drug Resistance in Gynecological Cancers.2005
- Author(s)
  Soh, Y., Goto, S., Kitajima, M., Moriyama, S., Kotera, K., Nakayama, T., Nakajima, H., Kondo, T., Ishimaru, T.
- Journal Title
  
  Clinical Oncology, 17(4)
  
  Pages : 264-270
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590247
[Journal Article] Nuclear Localization of Glutathione S-Transferase π is an Evaluation Factor for Drug Resistance in Gynecological Cancers.2005
- Author(s)
  Soh, Y., Goto, S., et al.
- Journal Title
  
  Clinical Oncology (in press)
- Data Source
  KAKENHI-PROJECT-16590247
[Journal Article] Nuclear glutathione S-transferase π prevents apoptosis by reducing the oxidative stress-induced formation of exocyclic DNA adducts.2004
- Author(s)
  Kamada, K., Goto, S., et al.
- Journal Title
  
  Free Radical.Biol.Med. 37(11)
  
  Pages : 1875-1884
- Data Source
  KAKENHI-PROJECT-16590247
[Journal Article] Nuclear glutathione S-transferase p prevents apoptosis by reducing the oxidative stress-induced formation of exocyclic DNA adducts.2004
- Author(s)
  Kamada, K., Goto, S., Okunaga, T., Ihara, Y., Tsuji, K., Kawai, Y., Uchida, K., Osawa, T., Matsuo, T., Nagata, I., Kondo, T.
- Journal Title
  
  Free Radical.Biol.Med., 37(11)
  
  Pages : 1875-1884
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590247
[Journal Article] Nuc1ear glutathione S-transferase π prevents apoptosis by reducing the oxidative stress-induced formation of exocyclic DNA adducts.2004
- Author(s)
  Kamada, K., Goto, S., et al.
- Journal Title
  
  Free Radical. Biol. Med. 37(11)
  
  Pages : 1875-1884
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590247
[Presentation] Radiation-induced damages on cardiac stem cells and myocardial regeneration may indirectly indicate future cardiovascular disease risks2016
- Author(s)
  Lan Luo1, Kodai Nishi2, Yoshishige Urata, Chen Yan, Shinji Goto, Takashi Kudo, Tao-Sheng Li
- Organizer
  日本放射線影響学会第59回大会
- Place of Presentation
  JMSアステールプラザ（広島県・広島市）
- Year and Date
  2016-10-26
- Data Source
  KAKENHI-PROJECT-26293279
[Presentation] 放射線被ばくによる心血管疾患リスクに関する実験的科学評価2015
- Author(s)
  羅蘭、浦田芳重、後藤信治、小野悠介、李桃生
- Organizer
  第５６回原子爆弾後障害研究会
- Place of Presentation
  広島国際会議場
- Year and Date
  2015-06-06
- Data Source
  KAKENHI-PROJECT-26293279
[Presentation] Radiation-induced damage of cardiac stem cells in quantity and quality2015
- Author(s)
  Lan Luo, Yoshishige Urata, Shinji Goto, Yusuke Ono, Tao-Sheng Li
- Organizer
  ICRR2015 Kyoto Japan - 15th International Congress of Radiation Research
- Place of Presentation
  京都府京都市国際会議場
- Year and Date
  2015-05-25
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293279
[Presentation] The mechanism of drug resistance of CD133-expressed cancer cell2015
- Author(s)
  後藤信治、浦田芳重、小野悠介、李桃生
- Organizer
  日本生化学会
- Place of Presentation
  神戸国際会議場(神戸市、兵庫県）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25462061
[Presentation] Radiation-induced damage of cardiac stem cells in quantity and quality
- Author(s)
  Lan Luo, Yoshishige Urata, Shinji Goto, Yusuke Ono, Tao-Sheng Li
- Organizer
  ＩＣＲＲ２０１５
- Place of Presentation
  京都国際会館
- Year and Date
  2015-05-25 – 2015-05-29
- Data Source
  KAKENHI-PROJECT-26293279

1. URATA Yosisige (30185087)

# of Collaborated Projects : 6results

# of Collaborated Products : 10results
2. KONDO Takahito (00158908)

# of Collaborated Projects : 4results

# of Collaborated Products : 2results
3. IHARA Yoshito (70263241)

# of Collaborated Projects : 4results

# of Collaborated Products : 1results
4. LI Taosheng (50379997)

# of Collaborated Projects : 3results

# of Collaborated Products : 14results
5. KAWAKATSU Miho (20398150)

# of Collaborated Projects : 1results

# of Collaborated Products : 2results
6. KOIKE Kichiko (80039619)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
7. 小池吉子 (10039521)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
8. 工藤崇 (20330300)

# of Collaborated Projects : 1results

# of Collaborated Products : 2results
9. 小野悠介 (60601119)

# of Collaborated Projects : 1results

# of Collaborated Products : 6results
10. HORII Akira

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
11. SAIKI Yuriko

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
12. 黄文敬

# of Collaborated Projects : 0results

# of Collaborated Products : 1results

GOTO Sinji 後藤 信治

Research Projects

Research Products

Co-Researchers

放射線治療副作用の軽減とがん転移の抑制を両立する治療薬の開発Ongoing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

がん幹細胞の代謝特性を標的とした新規がん治療法の開発Principal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Radiation-induced injury in tissue-specific stem cells for evaluating non-cancer disease risks

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The explore of new cancer stem cell marker based on intracellular behavior of biological defense factorPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular mechanism of intracellular localization of glutathione S-transferase πPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Effect of nuclear glutathione on DNA damage by irradiation

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Basic Research of Novel Molecular Target on Cancer ChemotherapyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The effect of melatonin on the cell proliferation

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

細胞におけるグルタチオン-シスプラチン結合体の形成と排出機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ガン細胞のシスプラチン耐性獲得機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

慢性肺気腫の膜受容体を介した新しい治療法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

原発性胆汁性肝硬変症の自己抗原のエピトープ解析と臨床応用

Principal Investigator

Project Period (FY)

Research Category

Research Institution

Pyruvate Dehydrogenase Gene: Regulation of its Expression and Identification of Mutation in the PCR-amplified Exon Segments from the Patient with Fatal Deficiency

Principal Investigator

Project Period (FY)

Research Category

Research Field

GOTO Sinji 後藤信治