KONDO Takahito 近藤宇史

Researcher Number	00158908
Affiliation (based on the past Project Information) *help	2002 – 2005: Course of Medical and Dental Science, Graduate School of Biomedical Science, professor, 大学院・医歯薬学総合研究科, 教授 1993 – 2002: 長崎大学, 医学部, 教授 1988 – 1991: 北海道大学, 医学部, 講師 1986: Hokkaido University School of Medicine, Instructor, 医学部, 助手
Review Section/Research Field	Principal Investigator Pathological medical chemistry / Biological pharmacy / General medical chemistry / 内分泌・代謝学 / Hematology Except Principal Investigator Metabolomics / 内分泌・代謝学 / Pathological medical chemistry / Laboratory animal science / Respiratory organ internal medicine … More / Laboratory medicine / Hematology / Circulatory organs internal medicine / Risk sciences of radiation/Chemicals / Pathological medical chemistry Less
Keywords	Principal Investigator グルタチオン / ATPase / 赤血球 / 膜輸送 / Erythrocyte / Glutathione / γ-グルタミルシステイン合成酵素 / glutathione / グルタチオンSー抱合体 / グルタチオン抱合体 … More / Membrane Transport / Glutathione S-Conjugate / 細胞障害 / 薬剤耐性 / アンチオキシダント / 酸化的ストレス / gamma-Glutamylcystein Synthetase / Citotoxicity / Drag Resistance / Antioxidant / Transport / γ-グルタミルシステイン / リボザイム / 糖尿病 / β-細胞 / レドックス / NF-kB / TNF-α / NF-κB / マウスβ細胞 / β-GCS / サイトカイン / gamma-glutamylcysteine / ribozyme / IDDM / beta-Cell / redox / NF-_kB / TNF-alpha / 膵β細胞 / インスリン / ハンマーヘッドリボザイム / pancreatic β-cells / γ-glutamylcysteine synthetase / insulin / hammerhead ribozyme / カーボニックアンヒドラーゼI / 原発性アルドステロン症 / Carbonic anhydrase I / Primary aldosteronism / グルタチオンS-抱合体 / ATP use / ERYTHROYCTES / MEMBRANE TRANSPORT / GLUTATHIONE / GLUTATHIONE S-CONJUGATE … More Except Principal Investigator γ-GCS / アポトーシス / グルタチオン / apoptosis / LCMV / アンチオキシダント / 奇形 / glutathione S-transferase π / Bax / Bcl-2 / オキシダント / 胎仔培養 / スカヴェンジャーシステム / フリーラジカル / embryo culture / glutathione / free radical / hyperglycemia / antioxidant system / scavenger system / 糖尿病 / ATL / CD95 / 8-OHdG / VEGF / RZR / ROR / activator protein-1 / ERK1 / 2 / リンパ球性脈絡髄膜炎ウイルス / 診断用組換え抗原 / Recombinant antigen / nuclear translocation / cisplatin / cancer / drug resistance / doxorubicin / GST / Akt / p53 / oxidative stress / exocyclic DNA adducts / anti-cancer drug resistance / nucleus / 多発性外骨腫 / 遺伝子 / ポジショナルクローニング / 染色体転座 / 3′RACE法 / 遺伝子発現 / RT-PCR / 軟骨細胞 / embryo(胎芽) / 肺気腫 / 胸部CT / 気管支肺胞洗浄 / 肺胞マクロファージ / 好中球エラスターゼ / エラスチン / 喫煙 / 中高年者 / EDP / 胸部CT検査 / アルファ1-アンチトリプシン / α1-アンチトリプシン / Emphysema / Computed tomography / Bronchoalveolar lavage / Alveolar macrophage / Neutrophil elastase / Oxidant / Antioxidant / Elastin / 成人呼吸切迫症候群(ARDS) / Mn-スーパーオキシドディスムターゼ(Mn-SOD) / 敗血症 / 酵素免疫測定法(ELISA) / Mn-SOD / ARDS / モノクローナル抗体 / Adult respiratory distress syndrome (ARDS) / Manganese superoxide dismutase / Sepsis / 妊娠糖尿病ラット / 高血糖 / 胎仔 / 血管平滑筋 / 糖化反応 / 部位特異的変異 / アポリポプロテインE / ヘパリン結合性EGF様増殖因子 / γ-グルタミルトランスペプチダーゼ / r-グルタミルトランスペプチダーゼ / 糖鎖遺伝子 / γ-glutamyl transpeptidase / 糖タンパク質 / 糖転移酵素 / アポプロテインE / diabetes / vascular smooth muscle / glycation / site-directed mutagenesis / apolipoprotein E / heparin binding EGF-like growth factor / gamma-glutamyl transpeptidase / Apoptosis / Fas / GSH / ceramide / APOPTOSIS / FAS / OXIDANT / ANTIOXIDANT / GLUTATHIONE / 神経管閉鎖不全 / 糖尿病ラット / スカヴェンジャー / グルタチオン(GSH) / 胎芽 / 20%O_2 / embryo / bax / bcl-2 / organogenesis / malformation / diabetic pregnancy / メラトニン / 血管内皮増殖因子 / LCMウイルス / 遺伝子組換え抗原 / カルレティキュリン / 心筋細胞 / 分子シャペロン / calreticulin / cardiomyocyte / molecular chaperone / deug resistance / doxoruvicin / glutathione S-transferaseπ / glutathione S-transferasen / nuclear localization signal / mitochondria import signal / mitochondria Less

Molecular mechanism of intracellular localization of glutathione S-transferase π
- Principal Investigator
  
  GOTO Shinji
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Nagasaki University
Effect of nuclear glutathione on DNA damage by irradiation
- Principal Investigator
  
  URATA Yoshishige
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Risk sciences of radiation/Chemicals
- Research Institution
  Nagasaki University
Basic Research of Novel Molecular Target on Cancer Chemotherapy
- Principal Investigator
  
  GOTO Shinji
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Nagasaki University
Producing and Certification of Recombinant Antigen with LCMV Isolated in Japan for Diagnosis of LCMV Infection in Mice.
- Principal Investigator
  
  OHSAWA Kazutaka
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory animal science
- Research Institution
  Nagasaki University
Overexpression of calreticulin modulates protein kinase B/Akt signaling to promote apoptosis during cardiac differentiation of cadiomyoblast H9c2 cells
- Principal Investigator
  
  TODA Genji
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Nagasaki University
糖尿病の奇形発生におけるアポトーシスの誘導機構と分子メカニズムの解明
- Principal Investigator
  
  AKAZAWA Shoichi
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Nagasaki University
The effect of melatonin on the cell proliferation
- Principal Investigator
  
  URATA Yoshishige
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Nagasaki University
Producing of Recombinant Antigen with LCMV Isolated in Japan and Diagnosis of LCMV Infection in Mice
- Principal Investigator
  
  OHSAWA Kazutaka
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory animal science
- Research Institution
  Nagasaki University
Regulation of pancreatic β-cell function by glutathionePrincipal Investigator
- Principal Investigator
  
  KONDO Takahito
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Nagasaki University
Role of apoptosis and the expression of bax and bcl-2 on diabetic embryopathy
- Principal Investigator
  
  AKAZAWA Shoichi
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Nagasaki University
Antioxidant system and apoptosis in diabetes-induced embryonic malformation.
- Principal Investigator
  
  AKAZAWA Shoichi
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Nagasaki University
Significance of sugar moiery of recombinant glycoproteins
- Principal Investigator
  
  TANIGUCHI Naoyuki
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Osaka University
Study on the development of therapy for insulin-dependent diabetes melitus addressing the regulation of pancreatic beta-cells death.Principal Investigator
- Principal Investigator
  
  KONDO Takahito
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Nagasaki University
THE INVOLVEMENT OF OXIDANT AND ANTIOXIDANT SYSTEM IN FAS-MEDIATED APOPTOSIS OF ATL CELLS.
- Principal Investigator
  
  YAMADA Yasuaki
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Nagasaki University
多発性外骨腫(がん抑制遺伝子のポジショナルクローニングと発がん機構
- Principal Investigator
  
  新川詔夫
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Nagasaki University
Development and practical use of predictive methods of adult respiratory distress syndrome in patients with sepsis
- Principal Investigator
  
  TANIGUCHI Naoyuki
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  Laboratory medicine
- Research Institution
  Osaka University
Augmentation of Transport for Cisplatin-glutathione Adduct in Cisplatinresistant Cancer CellsPrincipal Investigator
- Principal Investigator
  
  KONDO Takahito
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Nagasaki University
Glutathione-dependent antioxidant system in diabetes-induced embryopathy.
- Principal Investigator
  
  AKAZAWA Shoichi
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Nagasaki University
ROLE OF ALVEOLAR MACROPHAGES IN PATHOGENESIS OF PULMONARY EMPHYSEMA
- Principal Investigator
  
  KAWAKAMI Yoshikazu
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  HOKKAIDO UNIVERSITY
Analysis of transport system for glutathione and glutathione conjugates as a factor of cell defense and drug metabolism.Principal Investigator
- Principal Investigator
  
  KONDO Takahito
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Hokkaido University
A NOVEL ATPase OF ERYTHROYCTE MEMBRANES IN RELATION TO TRANSPORT OF GLUTATHIONE AND GLUTATHIONE CONJUGATES.Principal Investigator
- Principal Investigator
  
  KONDO Takahito
- Project Period (FY)
  1988 – 1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  HOKKAIDO UNIVERSITY
Clinical and Basic Study on Human Erythrocyte Carbonic Anhydrase I-Presence of a Mixed Disulfide with Glutathione.Principal Investigator
- Principal Investigator
  
  KONDO Takahito
- Project Period (FY)
  1985 – 1986
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Hokkaido University

All 2005 2004

All Journal Article

[Journal Article] Nuclear Localization of Glutathione S-Transferase π is an Evaluation Factor for Drug Resistance in Gynecological Cancers.2005
- Author(s)
  Soh, Y., Goto, S., Kitajima, M., Moriyama, S., Kotera, K., Nakayama, T., Nakajima, H., Kondo, T., Ishimaru, T.
- Journal Title
  
  Clinical Oncology, 17(4)
  
  Pages: 264-270
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590247
[Journal Article] Nuclear glutathione S-transferase p prevents apoptosis by reducing the oxidative stress-induced formation of exocyclic DNA adducts.2004
- Author(s)
  Kamada, K., Goto, S., Okunaga, T., Ihara, Y., Tsuji, K., Kawai, Y., Uchida, K., Osawa, T., Matsuo, T., Nagata, I., Kondo, T.
- Journal Title
  
  Free Radical.Biol.Med., 37(11)
  
  Pages: 1875-1884
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590247

1. IHARA Yoshito (70263241)

# of Collaborated Projects: 6 results

# of Collaborated Products: 1 results
2. AKAZAWA Shoichi (10145261)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
3. GOTO Shinzi (50186889)

# of Collaborated Projects: 4 results

# of Collaborated Products: 2 results
4. KATNAMINE Shigeru (40161062)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. KOJI Takehito (30170179)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. TANIGUCHI Naoyuki (90002188)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. YAMASHITA Shunichi (30200679)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. URATA Yoshishige (30185087)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. OHSAWA Kazutaka (90244756)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. SATO Hiroshi (50072947)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. KAWAKAMI Yoshikazu (10001877)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. NISHIMURA Masaharu (00208224)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. MIYAMOTO Kenji (50190814)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. SUZUKI Keiichiro (70221322)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. FUJII Junichi (00222258)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. TOMONAGA Masao (40100854)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. YAMADA Yasuaki (60145232)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. KIJIMA Hiroshi (90204859)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. TODA Genji (00253659)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. YANO Katsusuke (50039864)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 新川詔夫 (00111170)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 陣野吉廣 (20179097)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 長瀧重信 (70010311)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. TSUKADA Yutaka

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. CHOUVAEV Vladimir V

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. YAMAMOTO Hirotaka

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. DENNIS James W

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. DEUTSCH Harold F

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. ANDERSON Mary E

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. SIEST Gerard

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. SCHACHTER Harry

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. 近藤英明

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

KONDO Takahito 近藤 宇史

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Regulation of pancreatic β-cell function by glutathionePrincipal Investigator

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Study on the development of therapy for insulin-dependent diabetes melitus addressing the regulation of pancreatic beta-cells death.Principal Investigator

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KONDO Takahito 近藤宇史