OHARA Yoshiro 大原義朗

… Alternative Names

大原義郎オオハラヨシロウ

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Researcher Number	50203914
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2010 – 2014: 金沢医科大学, 医学部, 教授 2006 – 2008: 金沢医科大学, 医学部, 教授 1994 – 2004: 金沢医科大学, 医学部, 教授 1990 – 1993: Department of Neurological Sciences Associate Professor, 医学部, 助教授 1989: 東北大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Neurology / Virology / Virology Except Principal Investigator Virology / Neurology / Educational technology
Keywords	Principal Investigator Theiler's virus / タイラーウイルス / 脱髄 / 持続感染 / L^蛋白 / macrophages / マクロファージ / IL-6 / HTLV-I / ミクログリア … More / demyelination / アポトーシス / L蛋白 / 病原性 / apoptosis / virus growth / a mutant virus / L^-expressing macrophages / L^ protein / 抗L^蛋白抗体 / L^蛋白非産生DAウイルス / L^蛋白欠損ウイルス / L^蛋白非産生変異ウイルス / L^蛋白発現マクロファージ / microtubules / virus persistence / L protein / 微小管 / 亜群特性的宿主細胞依存性ウイルス増殖 / Lタンパク / vector / lymphotoxin gene / CNS / ベクター / 外来遺伝子 / 中枢神経 / infected clones / lytic infection / THP-1 / HTLV-l / TM-12細胞 / HTLV-1 / 感染クローン / 溶解感染 / THP-1細胞 / Mononuclear infiltrates / Demyelination / Trypsin / Neutralizing epitope / Persistent infection / GDVII株 / トリプシン / 中和エピトーブ / サブセット / 浸潤単核球 / 蛋白分解酵素 / 中和エピトープ / Experimental allergic encephalomyelitis / Microglia / Wallerian degeneration / Major histocompatibility complex class II / Ia抗原 / EAE / Waller変性 / 受身EAE / 主要組織適合複合体 / primary culture / infectious cDNA / oligodendrocyte / 感染症cDNA / 初代培養 / 感染性cDNA / オリゴデンドロサイト / タイラ-ウイルス / Saffoldウイルス / 感染受容体 / Saffold virus / 脳・神経 / ウイルス / インターフェロン / L蛋白 … More Except Principal Investigator Northern blot / NF-kB / AP-1 / THP-1 / Lentivirus / Transgenic mouse / L protein / Demyelination / Theiler's virus / Multiple sclerosis / L^蛋白 / レンチウイルス / トランスジェニックマウス / L蛋白 / 脱髄 / タイラーウイルス / 多発性硬化症 / vRNP transport / BM2 protein / vRNP complex / influenza B virus / two-hybrid / ウイルス粒子形成 / インフルエンザウイルス / vRNPの細胞内輸送 / vRNP細胞内輸送 / BM2蛋白 / vRNP複合体 / インフルエンザBウイルス / Interleukin 8 / Cytomegalovirus / IL-8レセプター / ノーザンブロット / IL-8 / サイトメガロウイルス / SSL / VPN / 問題解決能力 / 報告能力 / 学外実習 / 教育支援システム / 学外臨床教育 / 伝達能力 / 要約 / 臨床 / ネットワーク / 臨床実習前準備教育 / 臨床実習 / 携帯電話 / 要約能力 / 音声 / プレゼンテーション能力 / 遠隔教育 Less

Saffoldウイルス感受性を規定する宿主因子の同定から指向した病原性解析Principal Investigator
- Principal Investigator
  
  大原義朗
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Virology
- Research Institution
  Kanazawa Medical University
Elucidation of the mechanism(s) modifying the co-operative apoptosis caused by Land L* proteins, which regulate the persistence of picornaviruses.Principal Investigator
- Principal Investigator
  
  OHARA Yoshiro
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Virology
- Research Institution
  Kanazawa Medical University
Electronic Support System with an Effective Network for Clinical Education
- Principal Investigator
  
  HORI Ariyuki
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Educational technology
- Research Institution
  Kanazawa Medical University
Analysis of the function of L^* protein of Theiler's virus (TV) by a lentiviral expression systemPrincipal Investigator
- Principal Investigator
  
  OHARA Yoshiro
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Virology
- Research Institution
  KANAZAWA MEDICAL UNIVERSITY
The analysis of mechanism of Theiler's virus-induced damyelination in L* protein transgenic mice
- Principal Investigator
  
  ASAKURA Kunihiko
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  KANAZAWA MEDICAL UNIVERSITY
The role of L* protein of Theiler's murine encephalomyelitis virus (TMEV)Principal Investigator
- Principal Investigator
  
  OHARA Yoshiro
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Kanazawa Medical University
characterizations and functions of influenza B virus BM2 protein.
- Principal Investigator
  
  ODAGIRI Takato
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Virology
- Research Institution
  National Institute of Infectious Diseases
  Kanazawa Medical University
Theiler's virus as a vector for foreign gene delivery into the CNSPrincipal Investigator
- Principal Investigator
  
  OHARA Yoshiro
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Kanazawa Medical University
Molecular mechanisms for enhancement of human cytomegalovirus replication by chemokine, interleukin 8
- Principal Investigator
  
  MURAYAMA Tsugiya
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Virology
- Research Institution
  Kanazawa Medical University
Establishment and characterization of human monocytic cell line (THP-1) infected with HTLV-1)Principal Investigator
- Principal Investigator
  
  OHARA Yoshiro
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Kanazawa Medical University
The role of macrophage-derived proteinase in Teller's virus-induced demyelinationPrincipal Investigator
- Principal Investigator
  
  OHARA Yoshiro
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Virology
- Research Institution
  Tohoku University
Studies on the relationship between demyelination and non-immnologically induced Ia antigen.Principal Investigator
- Principal Investigator
  
  OHARA Yoshiro, 照沼裕
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Tohoku University
Molecular Biological Studies on Demyelination Induced by Theiler's Virus Tohoku University School of MedicinePrincipal Investigator
- Principal Investigator
  
  OHARA Yoshiro
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Tohoku University

All 2015 2014 2013 2012 2011 2010 2005 2004 2003 2002 2000 1999 Other

All Journal Article Presentation Book

[Book] 神経感染症を究める2014
- Author(s)
  大原義朗, 長山成美, 辻省次, 水澤英洋, 他
- Publisher
  中山書店
- Data Source
  KAKENHI-PROJECT-25460571
[Book] 今日の神経疾患治療指針2013
- Author(s)
  大原義朗, 長山成美
- Publisher
  医学書院
- Data Source
  KAKENHI-PROJECT-25460571
[Book] ウイルス性脳炎.今日の神経疾患治療指針2013
- Author(s)
  大原義朗、長山成美
- Publisher
  第2版(水澤英洋、鈴木則宏、梶龍兒、吉良潤一、神田隆、齊藤延人)、株式会社医学書院
- Data Source
  KAKENHI-PROJECT-22590421
[Book] Curr.Top.Virol2004
- Author(s)
  Y.Ohara, T.Himeda, K.Asakura
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570273
[Book] Trends in Entomology2003
- Author(s)
  Y.Oikawa, T.Ikeda, Y.Ohara
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570273
[Book] Trends in Entomology2003
- Author(s)
  Y.Oikawa, T.Ikeda, Y.Ohara
- Publisher
  The NC mouse as a model for atpic dermatitis - a role of the mite antigen in its pathogenesis.
- Data Source
  KAKENHI-PROJECT-14570273
[Journal Article] Early insights into NMO recounted by a past member of the executive committee of the Japanese society for Neuroimmunology.2015
- Author(s)
  Y.Ohara
- Journal Title
  
  Clin. Exp. Neuroimmunol.
  
  Volume: 6 Pages: 9-10
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25460571
[Journal Article] Cell-to-cell- transmission in the pathogenesis of human T-lymphotropic virus type 1-associated myelopathy/tropical spastic paraparesis.2014
- Author(s)
  Y.Ohara
- Journal Title
  
  Clin. Exp. Neuroimmunol.
  
  Volume: 5 Issue: 2 Pages: 117-119
- DOI
  10.1111/cen3.12122
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25460571
[Journal Article] Role(s) of Leader protein of Saffold virus.2014
- Author(s)
  Shimizu A, Himeda T, Okuwa T, Muraki Y, Ohara Y
- Journal Title
  
  Clin Exp Neuroimmunol
  
  Volume: 3 Issue: 3 Pages: 1-5
- DOI
  10.1111/cen3.12109
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24590560, KAKENHI-PROJECT-24790449, KAKENHI-PROJECT-25460571, KAKENHI-PROJECT-26460561
[Journal Article] 医学と医療の最前線　脳髄膜炎の遺伝子診断2014
- Author(s)
  大原義朗, 森田明彦
- Journal Title
  
  日内会誌
  
  Volume: 103 Pages: 1942-1947
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25460571
[Journal Article] Saffold virus type3(SAFV-3)persists in HeLacells.2013
- Author(s)
  HimedaT,HosomiT,OkuwaT,MurakiY,OharaY
- Journal Title
  
  PLoSON
  
  Volume: E8:e53194
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590421
[Journal Article] Possibility of neuropathogenesis of Saffold virus suggested from the in vitro virus persistence.2013
- Author(s)
  Himeda T, Okuwa T, Muraki Y, Ohara Y
- Journal Title
  
  Clin Exp Neuroimmunol
  
  Volume: 4 Pages: 163-164
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460571
[Journal Article] Saffold virus type 3 (SAFV-3) persists in HeLa cells.2013
- Author(s)
  Himeda T, Hosomi T, Okuwa T, Muraki Y, Ohara Y
- Journal Title
  
  PLoS ONE
  
  Volume: 8 Issue: 1 Pages: e53194-e53194
- DOI
  10.1371/journal.pone.0053194
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590560, KAKENHI-PROJECT-24790449, KAKENHI-PROJECT-25460571
[Journal Article] Effect of cysteine mutations in the extracellular domain of CM2 on the influenza Cvirus replication.2013
- Author(s)
  Muraki Y, Okuwa T, Himeda T, Hongo S, Ohara Y
- Journal Title
  
  PLoS ONE
  
  Volume: 8: e60510
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590421
[Journal Article] Effect of cysteine mutations in the extracellular domain of CM2 on the influenza C virus replication.2013
- Author(s)
  Muraki Y, Okuwa T, Himeda T, Hongo S, Ohara Y.
- Journal Title
  
  PLoS One
  
  Volume: 8 Issue: 4 Pages: e60510-e60510
- DOI
  10.1371/journal.pone.0060510
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590536, KAKENHI-PROJECT-24590560, KAKENHI-PROJECT-25460571
[Journal Article] Intrinsic temperature sensitivity of influenza C virus hemagglutinin-esterase-fusion protein.2012
- Author(s)
  TakashitaE,MurakiY,SugawaraK,AsaaoH,NishimuraH,SuzukiK,TsujiT,HongoS,OharaY,KawaokaY,OzawaM,MatsuzakiY
- Journal Title
  
  JViro
  
  Volume: l86 Pages: 13108-13111
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590421
[Journal Article] Contamination of the cell sorter fluidics system with the water-borne bacterium Burkholderia cepacia.2012
- Author(s)
  MurakiY,HongoS,OharaY
- Journal Title
  
  Cytometry
  
  Volume: PartA81A Pages: 105-107
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590421
[Journal Article] Glycosylation of CM2 is important for efficient replication of influenza C virus2012
- Author(s)
  OkuwaT,MurakiY,HimedaT,OharaY
- Journal Title
  
  Virology
  
  Volume: 433 Pages: 167-175
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590421
[Journal Article] A new member of Cardiovirus : Unknown pathogenicity to humans2011
- Author(s)
  Ohara Y, et al
- Journal Title
  
  J.Plant Pathol.Microbiol.
  
  Volume: 2 Issue: 04 Pages: 4-4
- DOI
  10.4172/2157-7471.1000e101
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590421
[Journal Article] Reverse geneti canalysis of the recombination in Theilovirus based on the infectious cDNAclones2011
- Author(s)
  HimedaT,NojiriM,OkuwaT,MurakiY,OharaY
- Journal Title
  
  JPlant Pathol Microbiol
  
  Volume: 2:4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590421
[Journal Article] The anti-apoptotic protein L*ofTheiler's murine encephalomyelitis virus(TMEV)contains a mitochondrial targeting signal.2011
- Author(s)
  HimedaT,OkuwaT,NojiriM,MurakiY,OharaY
- Journal Title
  
  VirusRes
  
  Volume: 155 Pages: 381-388
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590421
[Journal Article] The preparation of an infectious full-length cDNA clone of Saffold virus.2011
- Author(s)
  HimedaT,HosomiT,AsifN,ShimizuH,OkuwaT,MurakiY,OharaY
- Journal Title
  
  Virol
  
  Volume: J8:110
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590421
[Journal Article] PalmitoylationofCM2isdispensabletoinfluenzaCvirusreplication.2011
- Author(s)
  MurakiY,OkuwaT,FurukawaT,MatsuzakiY,SugawaraK,HimedaT,HongoS,OharaY
- Journal Title
  
  Virus
  
  Volume: Res157 Pages: 99-105
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590421
[Journal Article] Opposite effects of two nonstructural proteins of Theiler's murine encephalomyelitis virus regulates apoptotic cell death inBHK-21cells2010
- Author(s)
  OkuwaT,TaniuraN,SaitoM,HimedaT,OharaY
- Journal Title
  
  Microb Immun
  
  Volume: 54 Pages: 639-643
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590421
[Journal Article] Activaion of the PI3K-Akt pathway by human Tcell leukemia virus type1(HTLV-1)on coprote in Tax increases Bcl3 expression,which is associated with enhanced growth of HTLV-1-infected T-cells.2010
- Author(s)
  SaitoK,SaitoM,TaniuraN,OkuwaT,OharaY
- Journal Title
  
  Virology
  
  Volume: 403 Pages: 173-180
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590421
[Journal Article] Leader(L)of Theiler's murine encephalomyelitis virus(TMEV)is required for virus growth in an murine macrophage-like cell line.2010
- Author(s)
  Ichinose-AsakuraK,TaniuraN,HimedaT,NojiriM,OkuwaT,OharaY
- Journal Title
  
  Virus Res
  
  Volume: 147 Pages: 224-230
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590421
[Journal Article] Cytokine/chemokine profile inJ774 macrophage cells persistently infected with DA stain of Theiler's murine encephalomyelitis virus(TMEV)2010
- Author(s)
  HimedaT,OkuwaT,MurakiY,OharaY
- Journal Title
  
  J Neuroviro
  
  Volume: l16 Pages: 219-229
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590421
[Journal Article] A lentiviral expression system demonstrates that L^* protein of Theiler's murine encephalomyelitis virus (TMEV) is essential for virus growth in a murine macrophage-like cell line.2005
- Author(s)
  T.Himeda, Y.Ohara, K.Asakura, Y.Kontani, M.Murakami, H.Suzuki, M.Sawada
- Journal Title
  
  Virus Res. 108
  
  Pages: 23-28
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570273
[Journal Article] A lentiviral expression system demonstrates that L^* protein of Theiler's murine encephalomyelitis virus (TMEV) has an anti-apoptotic effect in a macrophage cell line.2005
- Author(s)
  T.Himeda, Y.Ohara, K.Asakura, Y.Kontani, M.Sawada
- Journal Title
  
  Microbial Pathogenesis (in press.)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570273
[Journal Article] A lentiviral expression system demonstrates that L protein of Theiler's murine encephalomyelitis virus (TMEV) is essential for virus growth in a murine macrophage-like cell line.2005
- Author(s)
  T.Himeda, Y.Ohara, K.Asakura, Y.Kontani, M.Murakami, H.Suzuki, M.Sawada
- Journal Title
  
  Virus Res. 108
  
  Pages: 23-28
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570273
[Journal Article] A lentiviral expression system demonstrates that L^* protein of Theiler's murine encephalomyelitis virus (TMEV) is essential for virus growth in a murine macrophage-like cell line.2005
- Author(s)
  T.Himeda, Y.Ohara, K.Asakura, Y.Kontani, M.Murakami, H.Suzuki, M.Sawada
- Journal Title
  
  Virus Res 108
  
  Pages: 23-28
- Data Source
  KAKENHI-PROJECT-14570273
[Journal Article] Importance of amino acid 14(valine) within capsid protein VP2 of Theiler's murine encephalomyelitis virus (TMEV) for its neurovirulence.2005
- Author(s)
  B.Endoh, T.Himeda, K.Asakura, Y.Ohara
- Journal Title
  
  J.Kanazawa Med.Univ. 29(in press)
- NAID
  110004617777
- Data Source
  KAKENHI-PROJECT-14570273
[Journal Article] A lentiviral expression system demonstrates that L^* protein of Theiler's murine encephalomyelitis virus (TMEV) has an anti-apoptotic effect in a macrophage cell line.2005
- Author(s)
  T.Himeda, Y.Ohara, K.Asakura, Y.Kontani, M.Sawada
- Journal Title
  
  Microbial Pathogenesis (in press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570273
[Journal Article] A small out-of frame protein regulating the biological activities in a mouse model for human demyelinating desease.2004
- Author(s)
  Y.Ohara, T.Himeda, K.Asakura
- Journal Title
  
  Curr.Top.Virol 4
  
  Pages: 123-132
- Data Source
  KAKENHI-PROJECT-14570273
[Journal Article] Importance of amino acid 14 (valine) within capsid protein VP2 of Theiler's murine encephalomyelitis virus (TMEV) for its neurovirulence.2004
- Author(s)
  B.Endoh, T.Himeda, K.Asakura, Y.Ohara
- Journal Title
  
  J.Kanazawa Med.Univ. 29
  
  Pages: 97-102
- NAID
  110004617777
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570273
[Journal Article] Importance of amino acid 14(valine) within capsid protein VP2 of Theiler's murine encephalomyelitis virus (TMEV) for its neurovirulence.2004
- Author(s)
  B.Endoh, T.Himeda, K.Asakura, Y.Ohara
- Journal Title
  
  J.Kanazawa Med.Univ. 29
  
  Pages: 97-102
- NAID
  110004617777
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570273
[Journal Article] Influenza B virus BM2 protein is transported through the trans-golgi network as an intehral membrane protein.2003
- Author(s)
  S.Watanabe, M.Imai, Y.Ohara, T.Odagiri
- Journal Title
  
  J.Virol. 77
  
  Pages: 10630-10637
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570273
[Journal Article] A nonstructural viral protein, L^*, influences viral persistence and demyelination induced by Theiler' s murine encephalomyelitis virus (TMEV).2003
- Author(s)
  Y.Ohara, T.Himeda, Y.Kontani, K.Asakura
- Journal Title
  
  J.Kanazawa Med.Univ. 28
  
  Pages: 63-68
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570273
[Journal Article] NC mouse dermatitis as a model for human atopic dermatitis.2003
- Author(s)
  Y.Ohara, Y.Oikawa, T.Ikeda
- Journal Title
  
  J.Kanazawa Med.Univ. 28
  
  Pages: 6-10
- NAID
  110004299813
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570273
[Journal Article] Influenza B virus BM2 protein is transported through the trans- golgi network as an integral membrane protein.2003
- Author(s)
  S.Watanabe, M.Imai, Y.Ohara, T.Odagiri
- Journal Title
  
  J.Virol. 77
  
  Pages: 10630-10637
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570273
[Journal Article] A nonstructural viral protein, L^*, influences viral persistence and demylination induced by Theiler's murine encephalomyelitis virus (TMEV).2003
- Author(s)
  Y.Ohara, T.Himeda, Y.Kontani, K.Asakura
- Journal Title
  
  J.Kanazawa Med.Univ. 28
  
  Pages: 63-68
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570273
[Journal Article] Epitope-tagged L^* protein of Theiler's murine encephalomyelitis virus is expressed in the central nervous system in the acute phase of infection.2002
- Author(s)
  K.Asakura, H.Murayama, T.Himeda, Y.Ohara
- Journal Title
  
  J.Virol. 76
  
  Pages: 13049-13054
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570273
[Journal Article] Effects of L^* protein of Theiler's murine encephalomyelitis virus (TMEV) on its biological activities.2002
- Author(s)
  Y.Ohara, T.Himeda, K.Asakura, J.Yamamoto, H.Iizuka
- Journal Title
  
  J.Kanazawa Med.Univ. 27
  
  Pages: 108-111
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570273
[Journal Article] Distinct cell death mechanisms by Theiler's murine encephalomyelitis virus (TMEV) infection in microglia and macrophage.2002
- Author(s)
  Y.Ohara, T.Himeda, K.Asakura, M.Sawada
- Journal Title
  
  Neurosci.Lett. 327
  
  Pages: 41-44
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570273
[Journal Article] A Distinct cell death machanisms by Theiler's murine encephalomyelitis virus (TMEV) infection in microglia and macrophage.2002
- Author(s)
  Y.Ohara, T.Himeda, K.Asakura, M.Sawada
- Journal Title
  
  Neurosci.Lett. 327
  
  Pages: 41-44
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570273
[Journal Article] Establishment of human T-cell leukemia virus type I (HTLV-I)-infected human monocytic cell line.2002
- Author(s)
  Y.Ohara, T.Himeda
- Journal Title
  
  J.Kanazawa Med.Univ. 27
  
  Pages: 112-116
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570273
[Journal Article] L^* Protein of Theiler's Murine Encephalomyelitis Virus Is Required for Virus Growth in a Murine Macrophage-Like Cell Line.2000
- Author(s)
  Obuchi, M., Yamamoto, J., Odagiri, T., Uddin, M.N., Iizuka, H., Ohara, Y.
- Journal Title
  
  J.Virol. 74
  
  Pages: 4898-4901
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-11670306
[Journal Article] Expression of lymphotoxin gene inserted into Theiler's murine encephalomyelitis virus.1999
- Author(s)
  Obuchi, M., Odagiri, T., lizuka, H., Ohara Y.
- Journal Title
  
  Microbiol.Immunol. 43
  
  Pages: 83-86
- NAID
  10004788214
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-11670306
[Journal Article] Theiler's murine encephalomyelitis virus (TMEV) subgroup strain-specific infection in neural and non-neural cell lines.1999
- Author(s)
  Obuchi, M., Yamamoto, J., Uddin, N.M., Odagiri, T., lizuka, H., Ohara, Y.
- Journal Title
  
  Microbiol.Immunol. 43
  
  Pages: 885-892
- NAID
  10004791373
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-11670306
[Journal Article] The BM2 protein of influenza B virus is synthesized in the late phase of infection and incorporated into virions as a subviral component.1999
- Author(s)
  Odagiri, T., Hong J., Ohara, Y.
- Journal Title
  
  J.Gen.Virol. 80
  
  Pages: 2573-2581
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-11670306
[Presentation] Saffoldウイルスの持続感染と神経病原性の可能性2013
- Author(s)
  大原義朗, 姫田敏樹, 大桑孝子, 村木靖, 西山修平, 高橋利幸, 藤盛寿一, 三須建郎, 中島一郎,藤原一男, 糸山泰人, 青木正志, 石崎義人, 原寿郎, 中村龍文
- Organizer
  第18回日本神経感染症学会
- Place of Presentation
  シーガイヤコンベンションセンター（宮崎県宮崎市）
- Data Source
  KAKENHI-PROJECT-25460571
[Presentation] Saffoldウイルス（SAFV）Leader 蛋白のIFN産生抑制能の解析2013
- Author(s)
  姫田敏樹, 大桑孝子, 村木靖, 大原義朗
- Organizer
  第25回日本神経免疫学会
- Place of Presentation
  海峡メッセ（福岡県下関市）
- Data Source
  KAKENHI-PROJECT-25460571
[Presentation] 小児脳炎への関与が疑われるSaffoldウイルスのin vitro 持続感染2013
- Author(s)
  大原義朗, 姫田敏樹, 大桑孝子, 村木靖
- Organizer
  第54回日本神経学会学術集会
- Place of Presentation
  東京国際フォーラム（東京都千代田区）
- Data Source
  KAKENHI-PROJECT-25460571
[Presentation] Saffold virus感染と神経疾患の関係2012
- Author(s)
  大原義朗
- Organizer
  第17回神経感染症学会
- Place of Presentation
  京都（ホテルルビノ京都堀川）
- Data Source
  KAKENHI-PROJECT-22590421
[Presentation] Saffold ウイルス持続感染機序の解析と自然感染における標的ヒト臓器の検討2012
- Author(s)
  大原義朗、姫田敏樹
- Organizer
  平成24年度エンテロウイルス班会議
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22590421
[Presentation] InvitroにおけるSaffoldウイルスの持続感染2012
- Author(s)
  姫田敏樹、大桑孝子、村木靖、大原義朗
- Organizer
  第60回日本ウイルス学会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-22590421
[Presentation] 新しいピコルナウイルス感染症-ヒトカルジオウイルスを中心に-2012
- Author(s)
  大原義朗
- Organizer
  第44回日本小児感染症学会総会・学術集会教育講演
- Place of Presentation
  小倉
- Data Source
  KAKENHI-PROJECT-22590421
[Presentation] Saffoldvirus感染と神経疾患の関係2012
- Author(s)
  大原義朗、姫田敏樹、大桑孝子、村木靖、西山修平、高橋利幸、藤盛寿一、三須建郎、中島一郎、藤原一男、糸山泰人、青木正志、石崎義人、原寿郎、中村龍文
- Organizer
  第17回日本神経感染症学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-22590421
[Presentation] カルジオウイルスの持続感染とIFN応答2012
- Author(s)
  姫田敏樹、大桑孝子、村木靖、大原義朗
- Organizer
  第24回日本神経免疫学会
- Place of Presentation
  軽井沢
- Data Source
  KAKENHI-PROJECT-22590421
[Presentation] 新しいピコルナウイルス感染症－ヒトカルジオウイルスを中心に-2012
- Author(s)
  大原義朗
- Organizer
  第44回日本小児感染症学会総会・学術集会
- Place of Presentation
  福岡（北九州国際会議場）
- Invited
- Data Source
  KAKENHI-PROJECT-22590421
[Presentation] Reverse genetics of Saffold virus2012
- Author(s)
  HimedaT,OkuwaT,MurakiY,OharaY
- Organizer
  17 th Europic 2012
- Place of Presentation
  San Rafael
- Data Source
  KAKENHI-PROJECT-22590421
[Presentation] 末梢血を対象としたMSにおけるSaffoldウイルス感染の解析2012
- Author(s)
  大原義朗
- Organizer
  第53回日本神経学会
- Place of Presentation
  東京（東京国際フォーラム）
- Data Source
  KAKENHI-PROJECT-22590421
[Presentation] ヒトカルジオウイルスのinvitroにおける持続感染2012
- Author(s)
  姫田敏樹、大桑孝子、村木靖、大原義朗
- Organizer
  第49回日本細菌学会中部支部総会
- Place of Presentation
  金沢
- Data Source
  KAKENHI-PROJECT-22590421
[Presentation] ヒトカルジオウイルス(Saffoldウイルス)Leader蛋白の機能解析2012
- Author(s)
  清水愛、姫田敏樹、大桑孝子、村木靖、大原義朗
- Organizer
  金沢医科大学医学会総会
- Place of Presentation
  金沢
- Year and Date
  2012-07-21
- Data Source
  KAKENHI-PROJECT-22590421
[Presentation] 末梢血を対象としたMSにおけるSaffoldウイルス感染の解析2012
- Author(s)
  大原義朗、姫田敏樹、村木靖、大桑孝子、西山修平、高橋利幸、藤盛寿一、三須建郎、中島一郎、藤原一男、糸山泰人、青木正志、中村龍文
- Organizer
  第53回日本神経学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22590421
[Presentation] Persistent infection of SAFV-3invitro2012
- Author(s)
  HimedaT,OkuwaT,MurakiY,OharaY
- Organizer
  Symposium Current Progress in Entero virus 71 Research in the Asia-Pacific Region
- Place of Presentation
  Tokyo
- Data Source
  KAKENHI-PROJECT-22590421
[Presentation] Synthesis of infectious Saffold virus type3 RNA byT7RNA polymerase is terminated by a human preproparathyroid hormone(PTH)signal in the viral genome.2011
- Author(s)
  HimedaT,HosomiT,AsifN,ShimizuH,OkuwaT,MurakiY,OharaY
- Organizer
  XVInternational Congress of Virology
- Place of Presentation
  Sapporo
- Data Source
  KAKENHI-PROJECT-22590421
[Presentation] 神経疾患とヒトカルジオウイルスSaffold Virusの関係2011
- Author(s)
  大原義朗, 他
- Organizer
  第52回日本神経学会総会
- Place of Presentation
  名古屋(名古屋国際会議場)
- Year and Date
  2011-05-19
- Data Source
  KAKENHI-PROJECT-22590421
[Presentation] 神経疾患におけるSaffold virus感染の疫学的調査2011
- Author(s)
  大原義朗, 他
- Organizer
  第16回日本神経感染症学会
- Place of Presentation
  東京(学術総合センター)
- Year and Date
  2011-11-04
- Data Source
  KAKENHI-PROJECT-22590421
[Presentation] Glycosylation o finfluenza C virus CM2 protein affects the early phase of viral replication.2011
- Author(s)
  OkuwaT,MurakiY,HimedaT,OharaY
- Organizer
  XV International Congress of Virology
- Place of Presentation
  Sapporo
- Data Source
  KAKENHI-PROJECT-22590421
[Presentation] 感染応答を制御する2つのウイルス非構成蛋白2011
- Author(s)
  姫田敏樹、大桑孝子、村木靖、大原義朗
- Organizer
  第23回日本神経免疫学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22590421
[Presentation] ヒトカルジオウイルス感染性クローンの樹立とリコンビネーションの検討2011
- Author(s)
  姫田敏樹、大桑孝子、村木靖、大原義朗
- Organizer
  第48回細菌学会中部支部総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-22590421
[Presentation] ヒトカルジオウイルス(Saffoldウイルス)感染性クローンの作製2011
- Author(s)
  姫田敏樹、細見卓司、NaeemAsif、清水博之、大桑孝子、村木靖、大原義朗
- Organizer
  第15回神経ウイルス研究会
- Place of Presentation
  金沢
- Data Source
  KAKENHI-PROJECT-22590421
[Presentation] The cysteine residues in the eztracellular domain of CM2 are dispensable but influence the influenza C virus replication.2011
- Author(s)
  MurakiY,OkuwaT,HimedaT,OharaY
- Organizer
  XVInternational Congress of Virology
- Place of Presentation
  Sapporo
- Data Source
  KAKENHI-PROJECT-22590421
[Presentation] 無菌性髄膜炎患者の髄液から分離されたヒトカルジオウイルス(Saffoldvirustype-3)のリバースジェネティクス2011
- Author(s)
  姫田敏樹、大桑孝子、村木靖、大原義朗
- Organizer
  平成23年度北陸腸内細菌研究会
- Place of Presentation
  富山
- Year and Date
  2011-07-09
- Data Source
  KAKENHI-PROJECT-22590421
[Presentation] RoleofpalmitoylationofCM2intheinfluenzaCvirusreplication2010
- Author(s)
  MurakiY,OkuwaT,FurukawaT,MatsuzakiY,SugawaraK,HimedaT,HongoS,OharaY
- Organizer
  OptionsforthecontrolofinfluenzaVII
- Place of Presentation
  HongKong
- Data Source
  KAKENHI-PROJECT-22590421
[Presentation] ウイルス持続感染マクロファージにみられる特異的サイトカイン産生とその役割2010
- Author(s)
  大原義朗
- Organizer
  第51回日本神経学会総会
- Place of Presentation
  東京(東京国際フォーラム)
- Year and Date
  2010-05-20
- Data Source
  KAKENHI-PROJECT-22590421
[Presentation] タイラーウイルス抗アポトーシス蛋白L*のミトコンドリア移行2010
- Author(s)
  姫田敏樹、大桑孝子、村木靖、大原義朗
- Organizer
  第58回日本ウイルス学会
- Place of Presentation
  徳島市
- Data Source
  KAKENHI-PROJECT-22590421
[Presentation] ウイルスと脱髄2010
- Author(s)
  大原義朗
- Organizer
  第8回HAM治療研究会
- Place of Presentation
  大阪(ホテルグランヴィア大阪)(招待講演)
- Year and Date
  2010-07-30
- Data Source
  KAKENHI-PROJECT-22590421
[Presentation] タイラーウイルス持続感染において特異的に変動するサイトカイン産生2010
- Author(s)
  大原義朗、姫田敏樹、大桑孝子、村木靖
- Organizer
  第15回神経感染症学会
- Place of Presentation
  福島市
- Data Source
  KAKENHI-PROJECT-22590421
[Presentation] Theprofileofcytokineexpressioninvolvedwithviruspersistenceandvirus-induceddemyelination.2010
- Author(s)
  OharaY,HimedaT,OkuwaT,MurakiY
- Organizer
  10thInternationalCongressofNeuroimmunology
- Place of Presentation
  Barcelona
- Data Source
  KAKENHI-PROJECT-22590421
[Presentation] The profile of cytokine expression involved with virus persistence and virus-induced demyelination2010
- Author(s)
  Ohara Y, et al
- Organizer
  10th International Congress of Neuroimmunology
- Place of Presentation
  Barcelona
- Data Source
  KAKENHI-PROJECT-22590421
[Presentation] タイラーウイルス抗アポトーシス蛋白L*の細胞内局在2010
- Author(s)
  姫田敏樹、大桑孝子、村木靖、大原義朗
- Organizer
  第47回日本細菌学会中部支部総会
- Place of Presentation
  新潟市
- Data Source
  KAKENHI-PROJECT-22590421
[Presentation] Mitochondrialtargetingofanti-apoptoticproteinL*ofTheiler'smurineencephalomyelitisvirus(TMEV).2010
- Author(s)
  HimedaT,NojiriM,OkuwaT,MurakiY,OharaY
- Organizer
  Europic2010,St
- Place of Presentation
  Andrews
- Data Source
  KAKENHI-PROJECT-22590421
[Presentation] タイラーウイルス持続感染において特異的に変動するサイトカイン産生2010
- Author(s)
  大原義朗, 他
- Organizer
  第15回日本神経感染症学会
- Place of Presentation
  福島(福島ビューホテル)
- Year and Date
  2010-10-08
- Data Source
  KAKENHI-PROJECT-22590421
[Presentation] マウスモデルからみたウイルス持続感染と脱髄
- Author(s)
  大原義朗
- Organizer
  第55回日本神経学会シンポジウム25
- Place of Presentation
  福岡国際会議場（福岡県博多区）
- Year and Date
  2014-05-21 – 2014-05-24
- Invited
- Data Source
  KAKENHI-PROJECT-25460571
[Presentation] 1型糖尿病剖検例における抗Saffoldウイルス抗体染色性
- Author(s)
  姫田敏樹, 大桑孝子, 村木靖, 大原義朗
- Organizer
  第62回日本ウイルス学会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2014-11-10 – 2014-11-12
- Data Source
  KAKENHI-PROJECT-25460571
[Presentation] 1型糖尿病を対象としたSaffoldウイルス感染の検索
- Author(s)
  姫田敏樹,大桑孝子, 村木　靖, 大原義朗
- Organizer
  第68回日本細菌学会東北支部総会
- Place of Presentation
  東北大学片平さくらホール（宮城県仙台市）
- Year and Date
  2014-08-22 – 2014-08-23
- Data Source
  KAKENHI-PROJECT-25460571
[Presentation] SaffoldウイルスL蛋白の機能解析
- Author(s)
  清水愛, 炭谷要子, 川村沙由美, 姫田敏樹, 大原義朗, 山田正仁
- Organizer
  第19回日本神経感染症学会･第26回日本神経免疫学会合同学術集会
- Place of Presentation
  金沢歌劇座（石川県金沢市）
- Year and Date
  2014-09-04 – 2014-09-06
- Data Source
  KAKENHI-PROJECT-25460571
[Presentation] SafffoldウイルスL蛋白の役割
- Author(s)
  姫田敏樹, 大桑孝子, 朝倉邦彦, 大原義朗
- Organizer
  第51回日本細菌学会中部支部会
- Place of Presentation
  北陸大学アネックス･ファーム（石川県金沢市）
- Year and Date
  2014-10-17 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-25460571
[Presentation] タイラーウイルス非構成蛋白の機能解析から示唆される細胞死制御機構.
- Author(s)
  姫田敏樹, 齊藤峰輝, 大桑孝子, 村木　靖, 谷浦直子, 大原義朗
- Organizer
  第18回日本神経ウイルス研究会
- Place of Presentation
  アクトシティ浜松(静岡県浜松市)
- Year and Date
  2014-06-20 – 2014-06-21
- Data Source
  KAKENHI-PROJECT-25460571
[Presentation] 1型糖尿病患者の脳内に認められた抗Scaffoldウイルス抗体染色性
- Author(s)
  大原義朗, 今野秀彦, 野島孝之, 姫田敏樹, 大桑孝子, 村木　靖
- Organizer
  第55回日本神経病理学会学術集会
- Place of Presentation
  学術総合センター(東京都千代田区)
- Year and Date
  2014-06-05 – 2014-06-07
- Data Source
  KAKENHI-PROJECT-25460571

1. OBUCHI Masatsugu (70257450)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
2. HIMEDA Toshiki (80340008)

# of Collaborated Projects: 4 results

# of Collaborated Products: 59 results
3. IWASAKI Yuzo (00142927)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. YASUDA Yukio (80097443)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. SUZUKI Koji (70064615)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. AINODA Noriko (50064605)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. MURAYAMA Tsugiya (60159184)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. ODAGIRI Takato (80177237)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
9. ASAKURA Kunihiko (50333159)

# of Collaborated Projects: 2 results

# of Collaborated Products: 16 results
10. HORI Ariyuki (80190221)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. KURODA Naohiro (80333160)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. TSUKAMOTO Tetsuro (20171978)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. KONNO Hidehiko (10091688)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. YAMAMOTO Teiji (10106487)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. KONTANI Yasuhide (30367461)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
16. 照沼裕 (50217436)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. OKUWA Takako

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
18. 小淵正次

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
19. 村木靖

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
20. 本郷誠治

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

OHARA Yoshiro 大原 義朗

大原 義郎 オオハラ ヨシロウ

Research Projects

Research Products

Co-Researchers

Saffoldウイルス感受性を規定する宿主因子の同定から指向した病原性解析Principal Investigator

Principal Investigator

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Elucidation of the mechanism(s) modifying the co-operative apoptosis caused by Land L* proteins, which regulate the persistence of picornaviruses.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Electronic Support System with an Effective Network for Clinical Education

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of the function of L^* protein of Theiler's virus (TV) by a lentiviral expression systemPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The analysis of mechanism of Theiler's virus-induced damyelination in L* protein transgenic mice

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The role of L* protein of Theiler's murine encephalomyelitis virus (TMEV)Principal Investigator

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characterizations and functions of influenza B virus BM2 protein.

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Theiler's virus as a vector for foreign gene delivery into the CNSPrincipal Investigator

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Molecular mechanisms for enhancement of human cytomegalovirus replication by chemokine, interleukin 8

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Establishment and characterization of human monocytic cell line (THP-1) infected with HTLV-1)Principal Investigator

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The role of macrophage-derived proteinase in Teller's virus-induced demyelinationPrincipal Investigator

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Studies on the relationship between demyelination and non-immnologically induced Ia antigen.Principal Investigator

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Molecular Biological Studies on Demyelination Induced by Theiler's Virus Tohoku University School of MedicinePrincipal Investigator

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OHARA Yoshiro 大原義朗

大原義郎オオハラヨシロウ

[Journal Article] 医学と医療の最前線　脳髄膜炎の遺伝子診断2014