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Hirota Seiichi  廣田 誠一

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HIROTA Seiichi  廣田 誠一

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Researcher Number 50218856
Other IDs
Affiliation (Current) 2025: 兵庫医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help 2016 – 2024: 兵庫医科大学, 医学部, 教授
2004 – 2014: Hyogo College of Medicine, Faculty of Medicine, Professor, 医学部, 教授
2007: 兵庫県医科大学, 医学部, 教授
2004: 兵庫医科大学, 病院・教授
2002 – 2003: 大阪大学, 医学部附属病院, 助教授 … More
2002: Osaka University Graduate School of Medicine, Associate Professor, 医学系研究科, 助教授
2001: 大阪大学, 医学研究科, 助教授
2001: 大阪大学, 医学部・附属病院, 助教授
2001: Osaka Univ., Div. Surg. Pathol., Associate Professor, 医学部付属病院, 助教授
2000: 大阪大学, 大学院・医学系研究科, 助教授
1999 – 2000: Osaka Univ. Med. Sch. associate professor, 医学系研究科, 助教授
1998: Osaka University Medical School, Associate Professor, 医学部, 助教授
1989 – 1998: 大阪大学, 医学部, 助手
1997: 大阪大学, 医学部・附属病院, 助手 Less
Review Section/Research Field
Principal Investigator
Experimental pathology / Biological Sciences / Experimental pathology / Basic Section 49030:Experimental pathology-related / Human pathology / Laboratory animal science
Except Principal Investigator
Experimental pathology / General surgery / Digestive surgery / Basic Section 49020:Human pathology-related … More / Digestive surgery / Experimental pathology / Basic Section 55010:General surgery and pediatric surgery-related / Basic Section 53020:Cardiology-related / Pediatric surgery / Environmental physiology (including Physical medicine and Nutritional physiology) / Basic veterinary science/Basic zootechnical science Less
Keywords
Principal Investigator
GIST / c-kit遺伝子 / 機能獲得性突然変異 / c-kit / c-kit gene / カハールの介在細胞 / ノックインマウス / ICCs / イマチニブ / 傍細胞膜領域 … More / germline / カハール介在細胞 / von Recklinghausen disease / PDGFR alpha / Imatinib / knock-in-mouse / model mouse / Familial and multiple GISTs / von Recklinghausen病 / PDGFレセプターアルファ / モデルマウス / 家族性多発性GIST / トランスジェニックマウス / ジーンターゲティング / germline mutation / Ws / exon17 / 二次耐性 / exon 17 / 生殖系列 / 患者予後 / 細胞外領域 / 腫瘍発生 / がん原遺伝子 / 間葉細胞腫 / 突然変異 / small intestinal GIST / antibody-drug conjugate / anti-CADM1 antibody / 診断と治療 / 特異抗体 / c-kit遺伝子変異 / GIST / 病理学 / Mutation / antibody / mutation / PDGFRA / クロナリティー / NF-1 gene mutation / germline c-kit gene mutation / 多発性GIST家系 / NF1遺伝子 / 機能獲得性の突然変異 / マウスモデル / transgenic mice / gene-targetting / geymline mutation / ICCS / C-Kit遺伝子 / Prognosis / gain-of-function mutation / interstitial cells of cajal / memory / fibrosis / intrapyloric pressure / mutant rats / 受容体チロシンキナーゼ / 近交系ラット / レセプターチロシンキナーゼ / 消化管ストローマ細胞腫 / 突然変異ラット / マスト細胞 / マスト細胞欠損ラット / c-kit レセプター / 海馬 / 中枢神経系 / Wsラット / 記憶 / 線維化 / 幽門内圧 / ミュータントラット / シグナル伝達 / 培養細胞 / 遺伝子変異 / チロシンキナーゼ / 消化管間質腫瘍 / シグナル伝達物質 / 家族性GIST / GIST多発家系 / nilotinib / imatinib / シグナル系 / 遺伝子改変マウス / キナーゼドメインII / exon13 / exon 13 / 付加変異 / 分子標的治療 / 腫瘍 / チロシンキナーゼ領域 / マスト細胞性腫瘍 / 多発性GIST / PDGFR / 遺伝子異常 / 家族性 / 腫瘍化 / 消化管間葉細胞腫 / 胆汁逆流 / 幽門収縮能 / c-kitレセプター / 消化管運動 / in situ ハイブリダイゼーション / マクロファージ / 動脈硬化 / 乳癌 / 異所性石灰沈着 / オステオポンチン / 骨基質蛋白 … More
Except Principal Investigator
マスト細胞 / c-kit / KIT / 転写因子 / マスト細胞欠損ラット / GIST / カハールの介在細胞 / マスト細胞プロテアーゼ / stem cell factor / c-kitレセプター / gain-of-function mutation / Interstitial Cells of Cajal / transcription factor / C-kit / Nippostrongylus brasiliensis / Ws / Stem Cell Factor / 好塩基球 / Stem cell factor / マスト細胞欠損マウス / KIT遺伝子 / 耐性 / イマチニブ / c-kit遺伝子 / 消化管間質腫瘍 / 消化管 / プロテアーゼ / mi遺伝子座 / c-fos / マウスミュータント / サブトラクション / 細胞接着 / チロシンキナーゼ / Ws遺伝子座 / W遺伝子座 / 突然変異マウス / 生殖細胞 / マスト細胞増殖因子 / cーkit癌原遺伝子 / 脂質メディエーター / サブタイプ / 腫瘍免疫微小環境 / 乳癌 / 腫瘍浸潤リンパ球 / びまん性大細胞型B細胞リンパ腫 / 遷延性血球減少 / 血球減少 / CAR-T細胞療法 / CAR-T細胞 / 光干渉断層画像 / 深層学習 / 動脈硬化 / 冠動脈疾患 / 血管内イメージング / 人工知能 / EBV関連リンパ増殖性疾患 / エプスタイン・バー・ウイルス (EBV) / PD-1/PD-L1免疫療法 / マクロファージ / JAK/STAT / 免疫チェックポイント阻害 / エプスタイン・バー・ウイルス / エプスタイン・バー・ウイルス関連リンパ増殖性疾患 / エプスタイン・バー・ウイルス関連腫瘍 / リンパ球浸潤 / 扁桃 / B細胞 / M2型マクロファージ / PD-L1 / EBV陽性腫瘍 / EBV陽性リンパ増殖性疾患 / EBV / Epstein-Barr virus / Allele / Sunitinib / Imatinib / Molecular target therapy / PDGFRA gene / KIT gene / Molecular mechanism of resistance / Gastrointestinal stromal tumor / PDGFR / ターゲット遺伝子 / 一次耐性 / PDGFRα遺伝子 / 二次耐性 / アリル / スニチニブ / 分子標的治療 / PDGFRA遺伝子 / 耐性機構 / Pyloric spsms / Congenital esophaged stenosis / Coordinatory movement / Atropine therapy / Infantile Hypertrophic pyloric stenosis / Upper gastrointestiral motor function / Microchannel monometry / Intestinal Pacemaker cell / 律動波 / 上部消化管通過障害 / 上部消化管運動 / マイクロチャンネルマイクロマノメトリー法 / 幽門れん縮 / 先天性食道狭窄症 / 協調運動 / アトロピン療法 / 肥厚性幽門狭窄症 / 上部消化管運動機能 / マイクロチャネルマイクロマノメトリー法 / 腸管ペースメーカー細胞 / Infection / iNOS / nitric oxide / Macrophage / Endotoxin / Intestinal motility / 微小循環 / NO / Nitric Oxide / 蠕動運動 / エンドトキシン / KIT蛋白質 / カハール細胞 / 腸管運動 / real-time RT-PCR / long-term potentiation / tetanic stimulation / mossy fiber-CA3 pathway / mutant rat / spatial learning and memory / CA3領域 / 中和抗体 / アラキドン酸 / Paired-pulse facilitation / シナプス可塑性 / c-kitミュータントラット / 隔離ストレス / 海馬スライス / テタヌス刺激 / リアルタイムPCR / c-kit mRNA / 肥満細胞増殖因子 / リアルタイムRT-PCR / 長期増強 / テタナス刺激 / 苔状線維-CA3回路 / ミュータントラット / 空間認知学習 / prognosis / recurrence / stromal tumors / proto-oncogene / gastrointestinal tract / 再発 / Interstitial Cells Cajal / 消化管平滑筋腫 / 予後 / 平滑筋腫 / Gastrointestinal Stromal Tumor / scurvy / chondrocyte / calcification / osteoblast / osteosarcoma / osteopontin / fracture lrealing / 偽関節 / 炎症 / 仮骨 / 骨形成不全 / 遺伝子発現 / コラーゲン / 膜性骨化 / 内軟骨性骨化 / 骨折 / ビタミンC / オステオネクチン / オステオカルシン / 壊血病 / 軟骨細胞 / 石灰化 / 骨芽細胞 / 骨肉腫 / オステオポンチン / 骨折治癒 / chymase / tryptase / cytokine receptor / cytokine / in situ hybridization / protease / mast cell / 粘膜型マスト細胞 / 結合組織マスト細胞 / 寄生虫感染 / in situ ハイブリダイゼーション / in sith ハイブリダイゼーション / キマ-ゼ / トリプターゼ / サイトカイン受容体 / サイトカイン / in situハイブリダイゼーション / Mast cell-deficient rat / Mouse / Rat / Immediate hypersensitivity / Basophil / Mast cell / 近交系ラット / アレルギーショック / 寄生虫 / アレルギー / マウス / ラット / stem ceel factor / 即時型アレルギー / precursor of mast cell / Cultured mast cells / stem cell factor (SCF) / histamine / FcepsilonRI / c-kit receptor / Ws rats / CFU-Mast / W^vマウス / W / 高親和性IgEレセプター(FcεRI) / マスト前駆細胞 / interleukin‐3(IL‐3) / マスト細胞前駆細胞 / stem cell factor(SCF) / cultured mast cell / ヒスタミン / 好親和性IgEレセプター(Fc ε RI) / Wsラット / Mast Cell-Deficient Rat / Mast Cell-Deficient Mouse / Mast Cell-Deficeint Animals / Receptor Tyrosine Kinase / Ws locus of rats / W locus of mice / Mast Cell / 線維芽細胞 / Sl遺伝子座 / CーKit遺伝子 / 接着因子 / cーkitレセプタ-のリガンド / cーkitレセプタ- / マスト細胞欠接ラット / レセプター・タイロンシンカイネース / マスト細胞腫 / レセプタータイロシンキナーゼ / マスト細胞欠損動物 / レセプターチロシンチナーゼ / 好酸球の侵潤 / サブスタンスP / 即時型アレルギー反応 / 免疫グロブリンE / ダニの排除 / アナフィラキシ- / マスト細胞の脱顆粒 / IgE / 培養マスト細胞 / 線維芽細胞との共生培養 / 結合組織型マスト細胞 / 肉腫 / 細胞培養 / 悪性化 / c-kit 遺伝子 / CADM1 / GISTs / IFNγ / 肝切後 / 癒着形成 / HGF / 肝細胞 / tPA / PAI-1 / IFN-γ / NKT細胞 / 肝切除後癒着 / 外科総論 / KIT遺伝子変異 / マイクロ・ダイセクション / ダイレクトシークエンス法 / 組織学的多様性 / 薬剤耐性腫瘍 / 消化管間質腫瘍(GIST) / 遺伝子分析 / 腸管蠕動不全 / 細胞内シグナル / アミノ酸 / exon17 / exon 17 / ノッタインマウス / 多発製GIST / ペースメーカー / 消化管運動 / 遺伝子改変動物 / 機能獲得性突然変異 / 生殖系列 / ノックインマウス / 多発性GIST / プロテオーム解析 / マイクロアレイ / 遺伝子変異 / KITチロシンキナーゼ / 糖鎖修飾 / 免疫系 / 平滑筋 / 上皮間リンパ球 / 核内移行シグナル / c-kit受容体チロシンキナーゼ / ルシフェラーゼ / セロトニン / グランザイム / サブトラクション・ライブラリー / 分化 / 細胞移動 / 核移行シグナル / mi転写因子 / ★骨細胞 / DNA結合タンパク / 骨大理石症マウス / メラノサイト / 突然変異ラット / タイロシンカイネース / 癌遺伝子 / レセプタ-・タイロシンカイネ-ス / SI遺伝子座 / 血液幹細胞 / 支持細胞 / 融合キメラ / タイロシンカイネースレセプター / ILー4 / ILー3 / 線維芽細胞株 Less
  • Research Projects

    (47 results)
  • Research Products

    (184 results)
  • Co-Researchers

    (67 People)
  •  Clinicopathological analysis of prolonged cytopenia after chimeric antigen receptor (CAR)-T cell therapy

    • Principal Investigator
      松田 育雄
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 49020:Human pathology-related
    • Research Institution
      Hyogo Medical University
  •  Anti-tumor effect of anti-CADM1 antibody conjugated with drug on small intestinal GISTPrincipal Investigator

    • Principal Investigator
      廣田 誠一
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 49030:Experimental pathology-related
    • Research Institution
      Hyogo Medical University
  •  乳癌における腫瘍浸潤リンパ球の分子病理学的解析と腫瘍免疫微小環境予測モデルの構築

    • Principal Investigator
      金岡 遥
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55010:General surgery and pediatric surgery-related
    • Research Institution
      Hyogo Medical University
  •  The Development of an Automatic Diagnosis System for Coronary Artery Atherosclerosis Using Deep Learning and Its Clinical Application

    • Principal Investigator
      Fujii Kenichi
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53020:Cardiology-related
    • Research Institution
      Kansai Medical University
  •  The development of methods for inhibition of PD-L1 expression towards suppression of Epstein-Barr virus-related tumors

    • Principal Investigator
      Matsuda Ikuo
    • Project Period (FY)
      2018 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 49020:Human pathology-related
    • Research Institution
      Hyogo Medical University
  •  Development of diagnostic method and its application to treatment in GIST with particular mutations through creating monoclonal antibodiesPrincipal Investigator

    • Principal Investigator
      Hirota Seiichi
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Human pathology
    • Research Institution
      Hyogo Medical University
  •  Analysis of gene expression on interstitial cells of Cajal

    • Principal Investigator
      ISOZAKI Koji
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Experimental pathology
    • Research Institution
      Hyogo Medical University
  •  腫瘍細胞株をもちいたGIST悪性化の関連分子の同定とその機能分析

    • Principal Investigator
      神田 達夫
    • Project Period (FY)
      2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Niigata University
  •  Influence of various types of receptor tyrosine kinase gene mutations in pathogenesis of GISTsPrincipal Investigator

    • Principal Investigator
      HIROTA Seiichi
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Experimental pathology
    • Research Institution
      Hyogo Medical University
  •  Analysis of molecular mechanism and the regulation of adhesion

    • Principal Investigator
      FUJIMOTO Jiro
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      General surgery
    • Research Institution
      Hyogo Medical University
  •  Diversity of imatinib-resistance clones in gastrointestinal stromal tumors

    • Principal Investigator
      KANDA Tatsuo
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Niigata University
  •  Role of glycosylation in the oncogenesis of gastrointestinal sarcoma

    • Principal Investigator
      NISHIDA Toshiro
    • Project Period (FY)
      2007 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Digestive surgery
    • Research Institution
      Osaka University
  •  A study of secondary resistance mechanism for molecular target drugs in gastrointestinal stromal tumorsPrincipal Investigator

    • Principal Investigator
      HIROTA Seiichi
    • Project Period (FY)
      2007 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Experimental pathology
    • Research Institution
      Hyogo College of Medicine
  •  Analysis of the molecular mechanism in gastrointestinal pacemaker cell using KIT knock-in animal

    • Principal Investigator
      ISOZAKI Koji
    • Project Period (FY)
      2007 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Experimental pathology
    • Research Institution
      Hyogo College of Medicine
  •  アミノ酸の惹起する細胞内シグナル伝達の基礎研究と腸管蠕動不全治療の研究アプローチ

    • Principal Investigator
      飯干 泰彦
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General surgery
    • Research Institution
      Hyogo Medical University
  •  Analysis of abnormal signaling through KIT and PDGFRA in development of gastrointestinal stromal tumorsPrincipal Investigator

    • Principal Investigator
      HIROTA Seiichi
    • Project Period (FY)
      2005 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Hyogo College of Medicine
  •  Molecular mechanisms of drug resistance in cancer.-GIST resistant to imatinib as a model-

    • Principal Investigator
      NISHIDA Toshirou
    • Project Period (FY)
      2004 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      General surgery
    • Research Institution
      Osaka University
  •  Pathological analysis of GIST using transgenic or knock-in-mousePrincipal Investigator

    • Principal Investigator
      HIROTA Seiichi
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      HyogoColfege of Medicine
      Osaka University
  •  Analysis of familial and multiple GISTPrincipal Investigator

    • Principal Investigator
      HIROTA Seiichi
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Experimental pathology
    • Research Institution
      Hyogo College of Medicine
      Osaka University
  •  Control Mechanism of Intestinal Pacemaker Cell on Upper Gastrointestinal Motor Function

    • Principal Investigator
      HASAGAWA Toshimichi
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatric surgery
    • Research Institution
      Osaka University
  •  ヒト消化管ストローマ細胞腫瘍(GIST)患者の予後に対するc-kit変異の影響Principal Investigator

    • Principal Investigator
      廣田 誠一
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      Osaka University
  •  消化管機能をコントロールする新たな細胞群

    • Principal Investigator
      尾崎 博
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Basic veterinary science/Basic zootechnical science
    • Research Institution
      The University of Tokyo
  •  Generation of gene-targetting mice with gain-of-function mutation of c-kit genePrincipal Investigator

    • Principal Investigator
      HIROTA Seiichi
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Experimental pathology
    • Research Institution
      Osaka University
  •  ヒト消化管ストローマ細胞腫瘍(GIST)とc-kitの変異Principal Investigator

    • Principal Investigator
      廣田 誠一
    • Project Period (FY)
      1999
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Osaka University
  •  Mechanisms of the gastrointestinal motility dysfunction under septic conditions - a role of Interstitial Cells of Cajal -

    • Principal Investigator
      NISHIDA Toshirou
    • Project Period (FY)
      1999 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Digestive surgery
    • Research Institution
      Osaka University
  •  ヒト消化管ストローマ細胞腫瘍の発生・悪性化とc-kit機能獲得性突然変異の関係Principal Investigator

    • Principal Investigator
      廣田 誠一
    • Project Period (FY)
      1998
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Osaka University
  •  Roles of brain mast cells and their related substances in the central mechanisms of stress responses

    • Principal Investigator
      KATAFUCHI Toshihiko
    • Project Period (FY)
      1998 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (B).
    • Research Field
      Environmental physiology (including Physical medicine and Nutritional physiology)
    • Research Institution
      KYUSHU UNIVERSITY
  •  Development of practically usefull Ws/Ws rat and its utilizationPrincipal Investigator

    • Principal Investigator
      HIROTA Seiichi, 北村 幸彦
    • Project Period (FY)
      1998 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (B).
    • Research Field
      Laboratory animal science
    • Research Institution
      Osaka University
  •  Relation between gain-of-function mutation of c-kit gene and development of GISTPrincipal Investigator

    • Principal Investigator
      HIROTA Seiichi
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Experimental pathology
    • Research Institution
      Osaka University
  •  ヒト消化管筋層の間葉細胞腫の発生におけるc-kit突然変異の意義Principal Investigator

    • Principal Investigator
      廣田 誠一
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Osaka University
  •  Role of the c-kit tyrosine kinase in the genesis of gastrointestinal stromal tumors.

    • Principal Investigator
      NISHIDA Toshirou
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Osaka University
  •  mi転写因子による受容体チロシンキナーゼ癌原遺伝子の発現制御

    • Principal Investigator
      野村 慎太郎
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Osaka University
  •  マスト細胞におけるmi転写因子の機能とその異常の分子病理学的解析

    • Principal Investigator
      北村 幸彦
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Experimental pathology
    • Research Institution
      Osaka University
  •  cーkitミュータントラットにおけるカハール介在細胞欠損と胃内胆汁逆流の関係Principal Investigator

    • Principal Investigator
      廣田 誠一
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Experimental pathology
    • Research Institution
      Osaka University
  •  細胞相互間の認識機構に広範囲な影響を与えるmiDNA結合蛋白標的遺伝子の単純

    • Principal Investigator
      野村 慎太郎
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Osaka University
  •  Molecular analysis of abnormal fracture healing process

    • Principal Investigator
      NOMURA Shintaro
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Experimental pathology
    • Research Institution
      Osaka University
  •  組織石灰化の分子病理学的研究Principal Investigator

    • Principal Investigator
      廣田 誠一
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Experimental pathology
    • Research Institution
      Osaka University
  •  c-kit Mutant Rats as a Tool for Mast Cell Research-Development and Function

    • Principal Investigator
      KATAMURA Yukihiko
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Institution
      Osaka University
  •  Analysis of Phenotypic Variation of Mast Cells by Using Messenger RNA Expression as a Marker

    • Principal Investigator
      KITAMURA Yukihiko
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Experimental pathology
    • Research Institution
      Osaka University
  •  チロシンキナーゼ受容体癌原遺伝子の発現を制御するmi遺伝子の分離同定

    • Principal Investigator
      野村 慎太郎
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Osaka University
  •  Research for Precursors of Mast Cells using Mast Cell-Deficient Ws/Ws Rats.

    • Principal Investigator
      KASUGAI Tsutomu
    • Project Period (FY)
      1993 – 1994
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Experimental pathology
    • Research Institution
      OSAKA UNIVERSITY
  •  c-kitレセプターを介した細胞間相互作用ーマウスとラットの突然変異の比較ー

    • Principal Investigator
      北村 幸彦
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Osaka University
  •  cーkitレセプタ-を介した細胞間相互作用ーマウスとラットの突然変異の比較ー

    • Principal Investigator
      北村 幸彦
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Osaka University
  •  Fibroblast-dependent Proliferation of Mast Cells

    • Principal Investigator
      KITAMURA Yukihiko
    • Project Period (FY)
      1990 – 1993
    • Research Category
      Grant-in-Aid for General Scientific Research (A)
    • Research Field
      Experimental pathology
    • Research Institution
      Osaka University
  •  細胞間相互作用が癌の増殖進展に与える影響:ミュータントマウス由来細胞による解析

    • Principal Investigator
      KITAMURA Yukihiko
    • Project Period (FY)
      1989
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Osaka University
  •  配偶子成熟に必要な微小環境に欠陥をもたらすマウスのSl突然変異の発生工学的解析

    • Principal Investigator
      北村 幸彦
    • Project Period (FY)
      1989
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Osaka University
  •  マスト細胞欠損マウスと培養マスト細胞を利用したマスト細胞機能解析システムの開発

    • Principal Investigator
      北村 幸彦
    • Project Period (FY)
      1988 – 1990
    • Research Category
      Grant-in-Aid for Developmental Scientific Research (B)
    • Research Field
      Experimental pathology
    • Research Institution
      Osaka University

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 Other

All Journal Article Presentation Book

  • [Book] Molecular mechanism and morphology in cancer2010

    • Author(s)
      Isozaki K, Hirota S.
    • Total Pages
      144
    • Publisher
      Bentham
    • Data Source
      KAKENHI-PROJECT-19590411
  • [Book] Gastrointestinal stromal tumor (GIST)診療ガイドラインGastrointestinal stromal tumor (GIST)診療ガイドライン2008

    • Author(s)
      久保田哲朗、杉野吉則、南学、廣田誠一、柳澤昭夫、大谷吉秀、西田俊朗、山村義孝、島田安博、高橋史朗
    • Publisher
      金原出版
    • Data Source
      KAKENHI-PROJECT-19390349
  • [Book] Gastrointestinal stromal tumor (GIST)診療ガイドライン2008

    • Author(s)
      久保田哲朗, 杉野吉則, 南学, 廣田誠一, 柳澤昭夫, 他
    • Total Pages
      126
    • Publisher
      金原出版 東京
    • Data Source
      KAKENHI-PROJECT-19390349
  • [Book] Gastrointestinal stromal tumors2006

    • Author(s)
      I shikawa T, Kanda T, Shincho M, Hirota S
    • Publisher
      Global Research Network, Kerala
    • Data Source
      KAKENHI-PROJECT-17013082
  • [Book] Gastrointestinal stromal tumor(GIST) : From Pathology to Molecular target therapy2004

    • Author(s)
      Hirota S, et al.
    • Total Pages
      176
    • Publisher
      Japan Scientific Societies Press, Tokyo, and Karger, Basel
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370076
  • [Book] Gastrointestinal stromal tumor (GIST) : From Pathology to Molecular target therapy2004

    • Author(s)
      Hirota S, et al.
    • Total Pages
      176
    • Publisher
      Japan Scientific Societies Press, Tokyo, and Karger, Basel
    • Data Source
      KAKENHI-PROJECT-14370076
  • [Book] Gastrointestinal stromal tumor (GIST) : From Pathology to Molecular target therapy2004

    • Author(s)
      Hirota S, et al.
    • Total Pages
      176
    • Publisher
      Japan Scientific Societies Press, Tokyo, and Karger, Basel
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-13214058
  • [Journal Article] EBV-positive Bile Duct Carcinoma Associated with Ulcerative Colitis2023

    • Author(s)
      Koichi Ikeo, Ikuo Matsuda, Seiichi Hirota
    • Journal Title

      Intern. Med.

      Volume: 62 Issue: 22 Pages: 3419-3420

    • DOI

      10.2169/internalmedicine.1501-22

    • ISSN
      0918-2918, 1349-7235
    • Year and Date
      2023-11-15
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K07003
  • [Journal Article] Automated classification of coronary atherosclerotic plaque in optical frequency domain imaging based on deep learning2021

    • Author(s)
      Shibutani H, Fujii K, Ueda D, Kawakami R, Imanaka T, Kawai K, Matsumura K, Hashimoto K, Yamamoto A, Hao H, Hirota S, Miki Y, Shiojima I.
    • Journal Title

      Atherosclerosis

      Volume: 328 Pages: 100-105

    • DOI

      10.1016/j.atherosclerosis.2021.06.003

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K08065
  • [Journal Article] Toxoplasma encephalitis followed by primary EBV-associated post-transplant lymphoproliferative disorder of the central nervous system in a patient undergoing allogeneic hematopoietic stem cell transplant: a case report.2020

    • Author(s)
      Azusa Mayumi, Takaya Yamashita, Ikuo Matsuda, Kenji Hikosaka, Satoshi Fujino, Kazumi Norose, Yasuyuki Kato, Seiichi Hirota, Toshiyuki Nakajima, Hiroyasu Ogawa , Kazuhiro Ikegame
    • Journal Title

      Transplantation Proceedings

      Volume: 52 Issue: 9 Pages: 2858-2860

    • DOI

      10.1016/j.transproceed.2020.08.002

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K07003, KAKENHI-PROJECT-19K07520
  • [Journal Article] An unusual case of duodenal gastrointestinal stromal tumour combined with the neuronal elements2019

    • Author(s)
      Iemura Y, Katsushima H, Kataoka TR, Hirota S, Shimada T
    • Journal Title

      Pathol Int.

      Volume: 印刷中

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16H05166
  • [Journal Article] Adherence to the guidelines and the pathological diagnosis of high-risk gastrointestinal stromal tumors in the real world2019

    • Author(s)
      Nishida T, Sakai Y, Takagi M, Ozaka M, Kitagawa Y, Kurokawa Y, Masuzawa T, Naito Y, Kagimura T, Hirota S, and the members of the STAR ReGISTry Study Group
    • Journal Title

      Gastric Cancer

      Volume: 印刷中 Issue: 1 Pages: 118-125

    • DOI

      10.1007/s10120-019-00966-4

    • NAID

      120006786938

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16H05166, KAKENHI-PROJECT-19H03722
  • [Journal Article] SOCS1 gene therapy has antitumor effects in imatinib-resistant gastrointestinal stromal tumor cells through FAK/PI3K signaling.2018

    • Author(s)
      Sugase T, Takahashi T, Serada S, Fujimoto M, Ohkawara T, Hiramatsu K, Nishida T, Hirota S, Saito Y, Tanaka K, Miyazaki Y, Makino T, Kurokawa Y, Yamasaki M, Nakajima K, Hanasaki K, Kishimoto T, Mori M, Doki Y, Naka T.
    • Journal Title

      Gastric Cancer.

      Volume: epub Issue: 6 Pages: 968-976

    • DOI

      10.1007/s10120-018-0822-1

    • NAID

      40021694606

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16H05419, KAKENHI-PROJECT-16K15600, KAKENHI-PROJECT-16H05166, KAKENHI-PROJECT-17H06844
  • [Journal Article] Coexistence of gastrointestinal stromal tumor and leiomyosarcoma of the stomach presenting as a collision tumor: a case report and review of literature.2018

    • Author(s)
      Kitagawa H, Kaneko M, Kano M, Ibuki Y, Amatya VJ, Takeshima Y, Hirota S, Hirabayashi N.
    • Journal Title

      Pathol Int.

      Volume: 68 Issue: 5 Pages: 313-317

    • DOI

      10.1111/pin.12662

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16H05166
  • [Journal Article] Clinicopathological features and prognosis of primary GISTs with tumor rupture in the real world.2018

    • Author(s)
      Nishida T, Cho H, Hirota S, Masuzawa T, Chiguchi G, Tsujinaka T, Kinki GIST Study Group
    • Journal Title

      Ann Surg Oncol.

      Volume: 25 Issue: 7 Pages: 1961-1969

    • DOI

      10.1245/s10434-018-6505-7

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16H05166, KAKENHI-PROJECT-16H05419
  • [Journal Article] Familial gastrointestinal stromal tumor with germline KIT mutations accompanying hereditary breast and ovarian cancer syndrome.2017

    • Author(s)
      Sekido Y, Ohigashi S, Takahashi T, Hayashi N, Suzuki K, Hirota S.
    • Journal Title

      Anticancer Res

      Volume: 37 Issue: 3 Pages: 1425-1431

    • DOI

      10.21873/anticanres.11466

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16H05166
  • [Journal Article] Genomic and transcriptomic analysis of imatinib resistance in gastrointestinal stromal tumors.2017

    • Author(s)
      Takahashi T, Elzawahry A, Mimaki S, Furukawa E, Nakatsuka R, Nakamura H, Nishigaki T, Serada S, Naka T, Hirota S, Shibata T, Tsuchihara K, Nishida T, Kato M.
    • Journal Title

      Genes Chromosomes Cancer.

      Volume: 56 Issue: 4 Pages: 303-313

    • DOI

      10.1002/gcc.22438

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16H05419, KAKENHI-PROJECT-16H05166, KAKENHI-PROJECT-15K10098
  • [Journal Article] Phase II study of neoadjuvant imatinib in large gastrointestinal stromal tumours of the stomach2017

    • Author(s)
      Kurokawa Yukinori、Yang Han-Kwang、Cho Haruhiko、Ryu Min-Hee、Masuzawa Toru、Park Sook Ryun、Matsumoto Sohei、Lee Hyuk-Joon、Honda Hiroshi、Kwon Oh Kyoung、Ishikawa Takashi、Lee Kyung Hee、Nabeshima Kazuhito、Kong Seong-Ho、Shimokawa Toshio、et al.
    • Journal Title

      British Journal of Cancer

      Volume: 117 Issue: 1 Pages: 25-32

    • DOI

      10.1038/bjc.2017.144

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K00044, KAKENHI-PROJECT-16H05166
  • [Journal Article] Prognostic factors after imatinib secondary resistance: survival analysis in patients with unresectable and metastatic gastrointestinal stromal tumors.2016

    • Author(s)
      Kanda T, Ishikawa T, Kosugi S-I, Ueki K, Naito T, Wakai T, Hirota S.
    • Journal Title

      Int J Clin Oncol.

      Volume: 21 Issue: 2 Pages: 295-301

    • DOI

      10.1007/s10147-015-0903-7

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16H05166, KAKENHI-PROJECT-26461970
  • [Journal Article] Clinicopathological characteristics, surgery and survival outcomes of patients with duodenal gastrointestinal stromal tumors.2016

    • Author(s)
      Sugase T, Takahashi T, Nakajima K, Hirota S, Masuzawa T, Nishida T, Kimura Y, Miyazaki Y, Makino T, Kurokawa Y, Yamasaki M, Takiguchi S, Mori M, Doki Y.
    • Journal Title

      Digestion.

      Volume: 94 Issue: 1 Pages: 30-36

    • DOI

      10.1159/000447665

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16H05166, KAKENHI-PROJECT-15K10098
  • [Journal Article] Detecting secondary c-KIT mutations in the peripheral blood of patients with imatinib-resistant gastrointestinal stromal tumor.2016

    • Author(s)
      Wada N, Kurokawa Y, Takahashi T, Hamakawa T, Hirota S, Naka T, Miyazaki Y, Makino T, Yamasaki M, Nakajima K, Takiguchi S, Mori M, Doki Y.
    • Journal Title

      Oncology

      Volume: 90 Issue: 2 Pages: 112-117

    • DOI

      10.1159/000442948

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16H05166, KAKENHI-PROJECT-26461977
  • [Journal Article] Gastrointestinal stromal tumors in Japanese patients with neurofibromatosis type I.2015

    • Author(s)
      Nishida T, Tsujimoto M, Takahashi T, Hirota S, Blay J-V, Wataya-Kaneda M.
    • Journal Title

      J Gastroenterol

      Volume: s00535 Issue: 6 Pages: 1132-6

    • DOI

      10.1007/s00535-015-1132-6

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26640110, KAKENHI-PROJECT-16H05166, KAKENHI-PROJECT-16H05419, KAKENHI-PROJECT-25461690, KAKENHI-PROJECT-16K10155, KAKENHI-PROJECT-16K15600
  • [Journal Article] Multiple gastrointestinal stromal tumors with novel germline c-kit gene mutation, K642T, at exon 132014

    • Author(s)
      Yamanoi K, Higuchi K, Kishimoto H, Nishida Y, Nakamura M, Sudoh M, Hirota S
    • Journal Title

      Human Pathol

      Volume: 45 Issue: 4 Pages: 884-888

    • DOI

      10.1016/j.humpath.2013.11.009

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390094
  • [Journal Article] A case of diffuse infiltrating gastrointestinal stromal tumor of sigmoid colon with perforation2014

    • Author(s)
      Yamashita D, Usami Y, Toyosawa S, Hirota S, Imai Y
    • Journal Title

      Pathol Int

      Volume: 64 Issue: 1 Pages: 34-38

    • DOI

      10.1111/pin.12124

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390094
  • [Journal Article] Subgroups of patients with very large gastrointestinal stromal tumors with distinct prognoses : a multicenter study2014

    • Author(s)
      Wada N, Kurokawa Y, Nishida T, Takahashi T, Toyokawa T, Kusanagi H, Hirota S, Tsujinaka T, Mori M, Doki Y
    • Journal Title

      J Surg Oncol

      Volume: 109 Issue: 2 Pages: 67-70

    • DOI

      10.1002/jso.23471

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390094
  • [Journal Article] Gastrointestinal stromal tumors with exon8 c-kit gene mutation might occur at extragastric sites and have metastasis-prone nature2014

    • Author(s)
      Ito T,Yamamura M,Hirai T,Ishikawa T,Kanda T,Nakai T,Ohkouchi M,Hashikura Y,Isozaki K,Hirota S
    • Journal Title

      In J Clin Exp Pathology

      Volume: 7 Pages: 80248031-80248031

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24590494
  • [Journal Article] Re-appraisal of risk classifications for primary gastrointestinal stromal tumors (GIST) after complete resection : indications for adjuvant therapy2014

    • Author(s)
      Yanagimoto Y, Takahashi T, Muguruma K, Toyokawa T, Kusanagi H, Omori T, Masuzawa T, Tanaka K, Hirota S, Nishida T
    • Journal Title

      Gastric cancer

      Volume: (In press) Issue: 2 Pages: 426-433

    • DOI

      10.1007/s10120-014-0386-7

    • Year and Date
      2014-05-23
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390094
  • [Journal Article] Adjuvant therapy with imatinib mesylate after resection of primary high-risk gastrointestinal stromal tumors in Japanese patients2013

    • Author(s)
      Kanda T, Nishida T, Wada N, Kobayashi O, Yamamoto M, Sawaki A, Boku N, Koseki M, Doi T, Toh Y, Kakeji Y, Sugiyama T, Komatsu Y, Kikuchi S, Ogoshi K, Katai H, Miyachi K, Hirota S, Ohtsu A
    • Journal Title

      Int J Clin Oncol

      Volume: 18 Issue: 1 Pages: 38-45

    • DOI

      10.1007/s10147-011-0339-7

    • NAID

      10031176233

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390094, KAKENHI-PROJECT-23590912
  • [Journal Article] Extracellular domain c-kit mutation with duplication of Ser501Ala502 found in gastrointestinal stromal tumors is more imatinib- and nilotinib-sensitive than that with duplication of Ala502Tyr5032013

    • Author(s)
      Liu N-N, Ohkouchi M, Hashikura Y, Kajimoto N, Matsuda I, Isozaki K, Toh Y, Takahashi T, Nishida T, Hirota S
    • Journal Title

      Lab Invest

      Volume: 93 Issue: 5 Pages: 502-507

    • DOI

      10.1038/labinvest.2013.43

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390094, KAKENHI-PROJECT-24590494
  • [Journal Article] Clinical significance of surgery for gastric submucosal tumors with size enlargement during watchful waiting period2013

    • Author(s)
      Miyazaki Y, Nakajima K, Kurokawa Y, Takahashi T, Takiguchi S, Miyata H, Yamasaki M, Hirota S, Nishida T, Mori M, Doki Y
    • Journal Title

      Eur J Cancer

      Volume: 49 Issue: 12 Pages: 2681-2688

    • DOI

      10.1016/j.ejca.2013.04.006

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390094
  • [Journal Article] Imatinib therapy for a patient with metastasis of colonic gastrointestinal stromal tumor : Report of a case2013

    • Author(s)
      Okamura T, Kanda T, Hirota S, Nishimura A, Kawahara M, Nikkuni K
    • Journal Title

      Clin J Gastroenterol

      Volume: 6 Issue: 2 Pages: 116-121

    • DOI

      10.1007/s12328-013-0365-2

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390094
  • [Journal Article] Prospective observational study of imatinib therapy in Japanese patients with advanced gastrointestinal stromal tumors : long-term follow-up and second malignancy2012

    • Author(s)
      Kanda T, Ishikawa T, Hirota S, Yajima K, Kosugi S, Ohashi M, Suzuki S, Mashima Y, Ajioka Y, Hatakeyama K
    • Journal Title

      Jpn J Clin Oncol

      Volume: 42 Issue: 7 Pages: 578-585

    • DOI

      10.1093/jjco/hys056

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390094
  • [Journal Article] Greater omentum gastrointestinal stromal tumor with PDGFRA-mutation and hemoperitoneum2012

    • Author(s)
      Murayama Y, Yamamoto M, Iwasaki R, Miyazaki T, Saji Y, Doi Y, Fukuda H, Hirota S, Hiratsuka M
    • Journal Title

      World J Gastroint Oncol

      Volume: 4 Issue: 5 Pages: 119-124

    • DOI

      10.4251/wjgo.v4.i5.119

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390094
  • [Journal Article] Characterization of novel germline c-kit gene mutation, KIT-Tyr553Cys, observed in a family with multiple gastrointestinal stromal tumors2012

    • Author(s)
      Nakai M, Hashikura Y, Ohkouchi M, Yamamura M, Akiyama T, Shiba K, Kajimoto N, Tsukamoto Y, Hao H, Isozaki K, Hirai T, Hirota S
    • Journal Title

      Lab Invest

      Volume: 92 Issue: 3 Pages: 451-457

    • DOI

      10.1038/labinvest.2011.165

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390094, KAKENHI-PROJECT-24590494
  • [Journal Article] Extra-gastrointestinal stromal tumor of the pelvic cavity : case report2012

    • Author(s)
      Hirano H, Yoshida T, Yoshimura H, Fukuoka M, Ohmura N, Nishizawa Y, Tachibana S, Hirota S, Zozumi M, Nishigami T
    • Journal Title

      Med Mol Morphol

      Volume: 45 Issue: 3 Pages: 173-177

    • DOI

      10.1007/s00795-011-0568-x

    • NAID

      10031073970

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390094
  • [Journal Article] 上部消化管疾患の実地臨床: GISTに対する内科治療2011

    • Author(s)
      神田達夫, 廣田誠一, 畠山勝義
    • Journal Title

      Medical Practice

      Volume: 28 Pages: 341-346

    • Data Source
      KAKENHI-PROJECT-21591694
  • [Journal Article] Secondary resistance to imatinib mesylate 70 months after innitiation of therapy in a patient with a metastatic gastric gastrointestinal stromal tumor2011

    • Author(s)
      Tatsuda K, Kanda T, Ishikawa T, Hirota S, 他
    • Journal Title

      Clin J Gastroenterol

      Volume: 4 Issue: 4 Pages: 218-222

    • DOI

      10.1007/s12328-011-0234-9

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591694, KAKENHI-PROJECT-23390094
  • [Journal Article] Secondary resistance to imatinib mesylate 70 months after initiation of therapy in a patient with a metastatic gastric gastrointestinal stromal tumor2011

    • Author(s)
      Tatsuda K, Kanda T, Ishikawa T, Hirota S, 他
    • Journal Title

      Clin J Gastroenterol

      Volume: 4 Pages: 218-22

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591694
  • [Journal Article] Good clinical response to imatinib mesylate in atypical thymic carcinoid with KIT overexpression2011

    • Author(s)
      Hamada S, Masago K, Mio T, Hirota S, Mishima M
    • Journal Title

      J Clin Oncol

      Volume: 29 Issue: 1 Pages: e9-e10

    • DOI

      10.1200/jco.2010.30.2455

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390094
  • [Journal Article] Familial gastrointestinal stromal tumor with germ line mutation of the juxtamembrane domain of the KIT gene observed in relatively young women2011

    • Author(s)
      Kuroda N, Tanida N, Hirota S, Daum O, Hes O, Michal M, Lee G-H
    • Journal Title

      Ann Diag Pathol

      Volume: 15 Issue: 5 Pages: 358-361

    • DOI

      10.1016/j.anndiagpath.2010.05.003

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390094
  • [Journal Article] 上部消化管疾患の実地臨床:GISTに対する内科治療2011

    • Author(s)
      神田達夫、廣田誠一、畠山勝義
    • Journal Title

      Medical Practice

      Volume: 28 Pages: 341-346

    • Data Source
      KAKENHI-PROJECT-21591694
  • [Journal Article] Urgent surgery for intraperitoneal bleeding from GIST during imatinib therapy2010

    • Author(s)
      E nomoto T, Kanda T, Yajima K, Hirota S, Matsuki A, Kosugi S-I, Kato T, Ajioka Y, Hatakeyama K
    • Journal Title

      Clin J Gastroenterol 3

      Pages: 73-77

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590410
  • [Journal Article] Urgent surgery for intraperitoneal bleeding from GIST during imatinib therapy.2010

    • Author(s)
      E nomoto T, Kanda T, Yajima K, Hirota S, Matsuki A, Kosugi S-I, Kato T, Ajioka Y, Hatakeyama K.
    • Journal Title

      Clin J Gastroenterol 3

      Pages: 73-77

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013082
  • [Journal Article] Intracranial metastasis from an esophageal gastrointestinal stromal tumor2010

    • Author(s)
      H amada S, Itami A, Watanabe G, Nakayama S, Tanaka E, Hojo M, Yoshizawa A, Hirota S, Sakai Y
    • Journal Title

      Intern Med 49

      Pages: 781-785

    • NAID

      130000251867

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590410
  • [Journal Article] Surgical resection of gastrointestinal stromal tumor of esophagus following preoperative imatinib treatment: a case report2010

    • Author(s)
      S ato H, Kanda T, Hirota S, Bamba T, Sakamoto K, Kosugi S, Matsuki A, Mashima Y, Watanabe G, Hatakeyama K
    • Journal Title

      Esophagus 7

      Pages: 65-69

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590410
  • [Journal Article] Surgical resection of gastrointestinal stromal tumor of esophagus following preoperative imatinib treatment : a case report2010

    • Author(s)
      Sato H, Kanda T, Hirota S, Bamba T, Sakamoto K, Kosugi S, Matsuki A, Mashima Y, Ajioka Y, Hatakeyama K
    • Journal Title

      Esophagus

      Volume: 7 Pages: 65-69

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591694
  • [Journal Article] Surgical resection of gastrointestinal stromal tumor of esophagus following preoperative imatinib treatment: a case report.2010

    • Author(s)
      S ato H, Kanda T, Hirota S, Bamba T, Sakamoto K, Kosugi S, Matsuki A, Mashima Y, Watanabe G, Hatakeyama K.
    • Journal Title

      Esophagus 7

      Pages: 65-69

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013082
  • [Journal Article] Intracranial metastasis from an esophageal gastrointestinal stromal tumor.2010

    • Author(s)
      H amada S, Itami A, Watanabe G, Nakayama S, Tanaka E, Hojo M, Yoshizawa A, Hirota S, Sakai Y.
    • Journal Title

      Intern Med. 49

      Pages: 781-785

    • NAID

      130000251867

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013082
  • [Journal Article] In vivo effect of imatinib on progression of cecal GIST-like tumors in exon 17-type c-kit knock-in mice2009

    • Author(s)
      Ishikawa T, Nakai N, Liu NN, Shiba K, Isozaki K, Matsuda I, Ito T, Fujimoto J, Hatakeyama K, Kanda T, Hirota S
    • Journal Title

      Lab Invest 89

      Pages: 1161-1168

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590411
  • [Journal Article] Involvement of focal adhesion kinase in the progression and prognosis of gastrointestinal stromal tumors2009

    • Author(s)
      K amo N, Naomoto Y, Shirakawa Y, Yamatsuji T, Hirota S, Fujiwaraa Y, Noma K, Sakurama K, Takaoka M, Nagatsuka H, Gunduz M, Matsuoka J, Tanaka N
    • Journal Title

      Human Pathol 40

      Pages: 1643-1649

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590410
  • [Journal Article] Sunitinib-resistant gastrointestinal stromal tumors harbor cis-mutations in the activation loop of the KIT gene. Japanese Study Group on GIST.2009

    • Author(s)
      N ishida T, Takahashi T, Nishitani A, Doi T, Shirao K, Komatsu Y, Nakajima K, Hirota S.
    • Journal Title

      Int J Clin Oncol. 14

      Pages: 143-149

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013082
  • [Journal Article] Gastric leiomyosarcoma manifesting peculiar findings: radiological-pathological correlation.2009

    • Author(s)
      M asuzawa N, Kishimoto M, Nishimura A, Ichiba N, Aoki E, Yanagibashi K, Hirota S, Yanagisawa A.
    • Journal Title

      Pathol Int. 59

      Pages: 306-311

    • NAID

      10027380056

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013082
  • [Journal Article] Inhibition of focal adhesion kinase as a potential therapeutic strategy for Imatinib-resistant gastrointestinal stromal tumor.2009

    • Author(s)
      S akurama K, Noma K, Takaoka M, Tomono Y, Watanabe N, Hatakeyama S, Ohmori O, Hirota S, Motoki T, Shirakawa Y, Yamatsuji T, Haisa M, Matsuoka J, Tanaka N, Naomoto Y.
    • Journal Title

      Mol Cancer Ther. 8

      Pages: 127-134

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013082
  • [Journal Article] In vivo effect of imatinib on progression of cecal GIST-like tumors in exon 17-type c-kit knock-in mice.2009

    • Author(s)
      I shikawa T, Nakai N, Liu N-N, Shiba K, Isozaki K, Matsuda I, Ito K, Fujimoto J, Hatakeyama K, Kanda T, Hirota S.
    • Journal Title

      Lab Invest. 89

      Pages: 1161-1168

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013082
  • [Journal Article] Establishment of a lymph node metastasis model from subcutaneous tumors of gastrointestinal stromal tumor model cells.2009

    • Author(s)
      S akurama K, Naomoto Y, Ohara T, Watanabe N, Takaoka M, Nagatsuka H, Tomono Y, Tanida T, Noma K, Tanabe S, Fujiwara Y, Motoki T, Shirakawa Y, Yamatsuji T, Hirota S, Taguchi T, Tanaka N.
    • Journal Title

      Oncol Rep. 21

      Pages: 407-411

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013082
  • [Journal Article] in vivo effect of imatinib on progression of cecal GIST-like tumors in exon 17-type c-kit knock-in mice2009

    • Author(s)
      Isozaki K, Ishikawa T, Nakai K, Hirota S
    • Journal Title

      Lab Invest 89

      Pages: 1161-1168

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590411
  • [Journal Article] Involvement of focal adhesion kinase in the progression and prognosis of gastrointestinal stromal tumors.2009

    • Author(s)
      K amo N, Naomoto Y, Shirakawa Y, Yamatsuji T, Hirota S, Fujiwaraa Y, Noma K, Sakurama K, Takaoka M, Nagatsuka H, Gunduz M, Matsuoka J, Tanaka N.
    • Journal Title

      Human Pathol 40

      Pages: 1643-1649

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013082
  • [Journal Article] In vivo effect of imatinib on progression of cecal GIST-like tumors in exon 17-type c-kit knock-in mice2009

    • Author(s)
      I shikawa T, Nakai N, Liu N-N, Shiba K, Isozaki K, Matsuda I, Ito K, Fujimoto J, Hatakeyama K, Kanda T, Hirota S
    • Journal Title

      Lab Invest 89

      Pages: 1161-1168

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590410
  • [Journal Article] Sunitinib-resistant gastrointestinal stromal tumors harbor cis-mutations in the activation loop of the KIT gene2009

    • Author(s)
      N ishida T, Takahashi T, Nishitani A, Doi T, Shirao K, Komatsu Y, Nakajima K, Hirota S
    • Journal Title

      Japanese Study Group on GIST. Int J Clin Oncol 14

      Pages: 143-149

    • NAID

      10025147879

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590410
  • [Journal Article] Inhibition of focal adhesion kinase as a potential therapeutic strategy for Imatinib-resistant gastrointestinal stromal tumor2009

    • Author(s)
      S akurama K, Noma K, Takaoka M, Tomono Y, Watanabe N, Hatakeyama S, Ohmori O, Hirota S, Motoki T, Shirakawa Y, Yamatsuji T, Haisa M, Matsuoka J, Tanaka N, Naomoto Y
    • Journal Title

      Mol Cancer Ther 8

      Pages: 127-134

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590410
  • [Journal Article] Sunitinib-resistant gastrointestinal stromal tumors harbor cis-mutations in the activation loop of the KIT gene.2009

    • Author(s)
      Nishida T, Takahashi T, Nishitani A, Doi T, Shirao K, Komatsu Y, Nakajima K, Hirota S
    • Journal Title

      Int J Clin Oncol 14(2)

      Pages: 143-9

    • NAID

      10025147879

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390349
  • [Journal Article] Establishment of a lymph node metastasis model from subcutaneous tumors of gastrointestinal stromal tumor model cells2009

    • Author(s)
      S akurama K, Naomoto Y, Ohara T, Watanabe N, Takaoka M, Nagatsuka H, Tomono Y, Tanida T, Noma K, Tanabe S, Fujiwara Y, Motoki T, Shirakawa Y, Yamatsuji T, Hirota S, Taguchi T, Tanaka N
    • Journal Title

      Oncol Rep 21

      Pages: 407-411

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590410
  • [Journal Article] Gastric leiomyosarcoma manifesting peculiar findings: radiological-pathological correlation2009

    • Author(s)
      M asuzawa N, Kishimoto M, Nishimura A, Ichiba N, Aoki E, Yanagibashi K, Hirota S, Yanagisawa A
    • Journal Title

      Pathol Int 59

      Pages: 306-311

    • NAID

      10027380056

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590410
  • [Journal Article] Secondary mutations in the kinase domain of the KIT gene are predominant in imatinib-resistant gastrointestinal stromal tumor2008

    • Author(s)
      N ishida T, Kanda T, Nishitani A, Takahashi T, Nakajima K, Ishikawa T, Hirota S
    • Journal Title

      Cancer Sci 99

      Pages: 799-804

    • NAID

      10024005223

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590410
  • [Journal Article] Abberant expression of glycosylation in juvenile gastrointestinal stromal tumors2008

    • Author(s)
      T akahashi T, Naka T, Fujimoto M, Serada S, Horino J, Terabe F, Hirota S, Miyoshi E, Hirai T, Nakajima K, Nishitani A, Souma Y, Sawa Y, Nishida T
    • Journal Title

      Proteomics Clin Appl 2

      Pages: 1246-1254

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590410
  • [Journal Article] A mouse modele of a human multiple GIST family with KIT-Asp820Tyr mutation generated by a knock-in strategy2008

    • Author(s)
      Isozaki K, Nakai N, Hirota S
    • Journal Title

      J Pathol 214

      Pages: 302-311

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590411
  • [Journal Article] Efficacy and Safety Profile of Imatinib Mesylate (STI571) in Japanese Patients with Advanced Gastrointestinal Stromal Tumors: a Phase II Study (STI571B1202)2008

    • Author(s)
      N ishida T, Shirao K, Sawaki A, Koseki M, Okamura T, Ohtsu A, Sugiyama T, Miyakawa K, Hirota S
    • Journal Title

      Int J Clin Oncol 13

      Pages: 244-251

    • NAID

      10024142467

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590410
  • [Journal Article] Secondary mutations in the kinase domain of the KIT gene are predominant in imatinib-resistant gastrointestinal stromal tumor.2008

    • Author(s)
      N ishida T, Kanda T, Nishitani A, Takahashi T, Nakajima K, Ishikawa T, Hirota S.
    • Journal Title

      Cancer Sci. 99

      Pages: 799-804

    • NAID

      10024005223

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013082
  • [Journal Article] A mouse model of human multiple GIST family with KIT-Asp820Tyr mutation generated by knock-in strategy.2008

    • Author(s)
      Nakai N, Ishikawa T, Nishitani A, Liu NN, Shincho M, Hao H, Isozaki K, Kanda T, Nishida T, Fujimoto J Hirota S.
    • Journal Title

      J Pathol 214(3)

      Pages: 302-311

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390349
  • [Journal Article] Cell adhesion molecule 1 is a novel pancreatic-islet cell adhesion molecule that mediates nerve-islet cell interactions2008

    • Author(s)
      Koma Y, Furuno T, Hagiyama M, Hamaguchi K, Nakanishi M, Masuda M, Hirota S, Yokozaki H, Ito A
    • Journal Title

      Gastroenterology 134

      Pages: 1544-1554

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590410
  • [Journal Article] Clinical practice guideline for gastrointestinal stromal tumor (GIST) in Japan.2008

    • Author(s)
      Nishida T, Hirota S, Yanagisawa A, Sugino Y, Minami M, Yamamura Y, Otani Y, Shimada Y, Takahashi F, Kubota T.
    • Journal Title

      Int J Clin Oncol 13

      Pages: 416-430

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390349
  • [Journal Article] Cell adhesion molecule 1 is a novel pancreatic-islet cell adhesion molecule that mediates nerve-islet cell interactions.2008

    • Author(s)
      Koma Y, Furuno T, Hagiyama M, Hamaguchi K, Nakanishi M, Masuda M, Hirota S, Yokozaki H, Ito A.
    • Journal Title

      Gastroenterology 134

      Pages: 1544-1554

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013082
  • [Journal Article] Abberant expression of glycosylation in juvenile gastrointestinal stromal tumors.2008

    • Author(s)
      T akahashi T, Naka T, Fujimoto M, Serada S, Horino J, Terabe F, Hirota S, Miyoshi E, Hirai T, Nakajima K, Nishitani A, Souma Y, Sawa Y, Nishida T.
    • Journal Title

      Proteomics Clin Appl. 2

      Pages: 1246-1254

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013082
  • [Journal Article] Secondary mutations in the kinase domain of the KIT gene are predominant in imatinib-resistant gastrointestinal stromal tumor.2008

    • Author(s)
      Nishida T, Kanda T, Nishitani A, Takahashi T, Nakajima K, Ishikawa T, Hirota S.
    • Journal Title

      Cancer Sci 99(4)

      Pages: 799-804

    • NAID

      10024005223

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390349
  • [Journal Article] Efficacy and Safety Profile of Imatinib Mesylate (STI571) in Japanese Patients with Advanced Gastrointestinal Stromal Tumors: a Phase II Study (STI571B1202).2008

    • Author(s)
      N ishida T, Shirao K, Sawaki A, Koseki M, Okamura T, Ohtsu A, Sugiyama T, Miyakawa K, Hirota S.
    • Journal Title

      Int J Clin Oncol. 13

      Pages: 244-251

    • NAID

      10024142467

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013082
  • [Journal Article] Aberrant Expression of Glycosylation in Juvenile Gastrointestinal Stromal Tumors.2008

    • Author(s)
      Takahashi T, Naka T, Fujimoto M, Serada S, Horino J, Terabe F, Hirota S, Miyoshi E, Hirai T, Nakajima K, Nishitani A, Souma Y, Sawa Y, Nishida T.
    • Journal Title

      Proteomics Clinical Applications 2

      Pages: 1246-1254

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390349
  • [Journal Article] Efficacy and Safety Profile of Imatinib Mesylate (STI571) in Japanese Patients with Advanced Gastrointestinal Stromal Tumors: a Phase II Study (STI571B1202).2008

    • Author(s)
      Nishida T, Shirao K, Sawaki A, Koseki M, Okamura T, Ohtsu A, Sugiyama T, Miyakawa K, Hirota S.
    • Journal Title

      Int J Clin Oncol 13

      Pages: 244-251

    • NAID

      10024142467

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390349
  • [Journal Article] Characterization of tyrosine kinase I domain c-kit gene mutation Asn655Lys newly found in primary jejunal GIST.2007

    • Author(s)
      Kinoshita K, Hirota S, Isozaki K, Nishitani A, Tsutsui S, Watabe K, Tamura S, Ishikawa T, Kanda T, Nishida T, Hayashi N
    • Journal Title

      Am J Gastroenterol 102(5)

      Pages: 1134-1136

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390349
  • [Journal Article] Surgical interventions for focal progression of advanced gastrointestinal stromal tumors under imatinib therapy.2007

    • Author(s)
      Hasegawa J, Kanda T, Hirota S, Fukuda M, Nishitani A, Takahashi T, Kurosaki I, Tsutsui S, Hatakeyama K, Nishida T.
    • Journal Title

      Surg Endosc.2007Inter J Clin Cancer.

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390363
  • [Journal Article] Characterization of tyrosine kinase I domain c-kit gene mutation Asn655Lys newly found in primary jejunal gastrointestinal stromal tumor.2007

    • Author(s)
      K inoshita K, Hirota S, Isozaki K, Nishitani A, Tsutsui S, Watabe K, Tamura S, Ishikawa T, Kanda T, Nishida T, Hayashi N.
    • Journal Title

      Am J Gastroenterol 102

      Pages: 1134-1136

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013082
  • [Journal Article] Surgical interventions for focal progression of advanced gastrointestinal stromal tumors during imatinib therapy.2007

    • Author(s)
      Hasegawa J, Kanda T, Hirota S, Fukuda M, Nishitani A, Takahashi T, Kurosaki I, Tsutsui S, Hatakeyama K, Nishida T.
    • Journal Title

      Int J Clin Oncol 12

      Pages: 212-217

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013082
  • [Journal Article] An enhanced risk-group stratification system for more practical prognostication of clinically malignant gastrointestinal stromal tumors2007

    • Author(s)
      Takahashi T, Nakajima K, Nishitani A, Souma Y, Hirota S, Sawa Y, Nishida T
    • Journal Title

      Int J Clin Oncol 12

      Pages: 369-374

    • NAID

      10019800300

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590410
  • [Journal Article] A mouse model of human multiple GIST family with KIT-Asp820Tyr mutation generated by knock-in strategy2007

    • Author(s)
      N akai N, Ishikawa T, Nishitani A, Liu N-N, Shincho M, Hao H, Isozaki K, Kanda T, Nishida T, Fujimoto J, Hirota S
    • Journal Title

      J Pathol 214

      Pages: 302-311

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590410
  • [Journal Article] Surgical interventions for focal progression of advanced gastrointestinal stromal tumors during imatinib therapy2007

    • Author(s)
      Hasegawa J, Kanda T, Hirota S, Fukuda M, Nishitani A, Takahashi T, Kurosaki I, Tsutsui S, Hatakeyama K, Nishida T
    • Journal Title

      Int J Clin Oncol 12

      Pages: 212-217

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590410
  • [Journal Article] Familial adenomatous polyposis complicated by chronic myelogenous leukemia: response to imatinib mesylate2007

    • Author(s)
      I tsukuma T, Ishikawa H, Misawa M, Kai S, Fujimori Y, Nakagawa K, Hirota S, Sugihara A, Terada N, Hara H
    • Journal Title

      J Gastroenterol 42

      Pages: 402-405

    • NAID

      10019483270

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590410
  • [Journal Article] A mouse model of human multiple GIST family with KIT-Asp820Tyr mutation generated by knock-in strategy.2007

    • Author(s)
      N akai N, Ishikawa T, Nishitani A, Liu N-N, Shincho M, Hao H, Isozaki K, Kanda T, Nishida T, Fujimoto J, Hirota S.
    • Journal Title

      J Pathol. 214

      Pages: 302-311

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013082
  • [Journal Article] Two cases of gastrointestinal stromal tumor of the stomach with lymph node metastasis.2007

    • Author(s)
      S ato T, Kanda T, Nishikura K, Hirota S, Hashimoto K, Nakagawa S, Ohashi M, Hatakeyama K.
    • Journal Title

      Hapato-Gastroenterol 54

      Pages: 1057-1060

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013082
  • [Journal Article] Familial adenomatous polyposis complicated by chronic myelogenous leukemia: response to imatinib mesylate.2007

    • Author(s)
      I tsukuma T, Ishikawa H, Misawa M, Kai S, Fujimori Y, Nakagawa K, Hirota S, Sugihara A, Terada N, Hara H.
    • Journal Title

      J Gastroenterol 42

      Pages: 402-405

    • NAID

      10019483270

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013082
  • [Journal Article] Juxtamembrane-type c-kit gene mutation found in aggressive systemic mastocytosis induces imatinib-resistant constitutive KIT activation.2007

    • Author(s)
      N akagomi N, Hirota S
    • Journal Title

      Lab Invest. 87

      Pages: 365-371

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013082
  • [Journal Article] An enhanced risk-group stratification system for more practical prognostication of clinically malignant gastrointestinal stromal tumors.2007

    • Author(s)
      Takahashi T, Nakajima K, Nishitani A, Souma Y, Hirota S, Sawa Y, Nishida T.
    • Journal Title

      Int J Clin Oncol. 12

      Pages: 369-374

    • NAID

      10019800300

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013082
  • [Journal Article] An enhanced risk-group stratification system for more practical prognostication of clinically malignant gastrointestinal stromal tumors.2007

    • Author(s)
      Takahashi T, Nakajima K, Nishitani A, Souma Y, Hirota S, Sawa Y, Nishida T.
    • Journal Title

      Int J Clin Oncol 12(5)

    • NAID

      10019800300

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390349
  • [Journal Article] Two cases of gastrointestinal stromal tumor of the stomach with lymph node metastasis2007

    • Author(s)
      S ato T, Kanda T, Nishikura K, Hirota S, Hashimoto K, Nakagawa S, Ohashi M, Hatakeyama K
    • Journal Title

      Hapato-Gastroenterol 54

      Pages: 1057-1060

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590410
  • [Journal Article] Surgical interventions for focal progression of advanced gastrointestinal stromal tumors under imatinib therapy.2007

    • Author(s)
      Hasegawa J, Kanda T, Hirota S, Fukuda M, Nishitani A, Takahashi T, Kurosaki I, Tsutsui S, Hatakeyama K, Nishida T
    • Journal Title

      Inter J Clin Oncol 12

      Pages: 212-217

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390349
  • [Journal Article] Characterization of tyrosine kinase I domain c-kit gene mutation Asn655Lys newly found in primary jejunal gastrointestinal stromal tumor2007

    • Author(s)
      K inoshita K, Hirota S, Isozaki K, Nishitani A, Tsutsui S, Watabe K, Tamura S, Ishikawa T, Kanda T, Nishida T, Hayashi N
    • Journal Title

      Am J Gastroenterol 102

      Pages: 1134-1136

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590410
  • [Journal Article] Juxtamembrane-type c-kit gene mutation found in aggressive systemic mastocytosis induces imatinib-resistant constitutive KIT activation2007

    • Author(s)
      N akagomi N, Hirota S
    • Journal Title

      Lab Invest 87

      Pages: 365-371

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590410
  • [Journal Article] Pathology of gastrointestinal stromal tumors.2006

    • Author(s)
      Hirota S, Iaozaki K
    • Journal Title

      Pathol Int. 56

      Pages: 1-9

    • NAID

      10017320864

    • Data Source
      KAKENHI-PROJECT-17013082
  • [Journal Article] Gain-of-function mutations of receptor tyrosine kinases in gastrointestinal stromal tumors.2006

    • Author(s)
      Isozaki K, Hirota S
    • Journal Title

      Current Genomics 7

      Pages: 469-475

    • Data Source
      KAKENHI-PROJECT-17013082
  • [Journal Article] Different expression of connexin 43 in gastrointestinal stromal tumours between gastric and small intestinal origin2005

    • Author(s)
      Nishitani A, Hirota S, Nishida T, Isozaki K, Hashimoto K, Nakagomi N, Matsuda H.
    • Journal Title

      J Pathol 206(4)

      Pages: 377-382

    • Data Source
      KAKENHI-PROJECT-16390363
  • [Journal Article] Different expression of connexin 43 in gastrointestinal stromal tumors between gastric and small intestinal origin.2005

    • Author(s)
      Nishitani A, Hirota S, Nishida T, Isozaki K, Hashimoto K, Nakagomi N, Matsuda H.
    • Journal Title

      J Pathol 206(4)

      Pages: 377-382

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390363
  • [Journal Article] Different inhibitory effect of Imatinib on phosphorylation of MAPK and Akt, and cell proliferation in cells expressing different types of mutant PDGF receptor alpha.2004

    • Author(s)
      Ohashi A, Kinoshita.K, Isozaki K, Nishida T, Shinomura Y, Kitamura Y, Hirota S
    • Journal Title

      Int J Cancer 111

      Pages: 317-321

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13214058
  • [Journal Article] Late resistance to imatinib therapy associated with a second KIT mutation in metastatic qastrointestinal stromal tumour.2004

    • Author(s)
      Wakai T, Hirota S, et al.
    • Journal Title

      Br J Cancer 90

      Pages: 2059-2061

    • Data Source
      KAKENHI-PROJECT-13214058
  • [Journal Article] Absence of c-kit gene mutations in gastrointestinal stromal tumours of neurofibromatosis type I patients.2004

    • Author(s)
      Kinoshita K, Hirota S.Isozaki K, Ohashi A, Nishida T, Kitamura Y, Shinomura Y, Matsuzawa Y
    • Journal Title

      J Pathol 202

      Pages: 80-85

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13214058
  • [Journal Article] Absence of c-kit gene mutations in gastrointestinal stromal tumours of neurofibromatosis type I patients.2004

    • Author(s)
      Kinoshita K, Hirota S, Isozaki K, Ohashi A, Nishida T, Kitamura Y, Shinomura Y, Matsuzawa Y
    • Journal Title

      J Pathol 202

      Pages: 80-85

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370076
  • [Journal Article] Late resistance to imatinib therapy associated with a second KIT mutation in metastatic gastrointestinal stromal tumour.2004

    • Author(s)
      Wakai T, Hirota S, et al.
    • Journal Title

      Br J Cancer 90

      Pages: 2059-2061

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370076
  • [Journal Article] Absence of c-kit gene mutations in gastrointestinal stromal tumours of neurofibromatosis type I patients.2004

    • Author(s)
      Kinoshita K, Hirota S, et al.
    • Journal Title

      J Pathol 202

      Pages: 80-85

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370076
  • [Journal Article] Late resistance to imatinib therapy associated with a second KIT mutation in metastatic gastrointestinal stromal tumour.2004

    • Author(s)
      Wakai T, Hirota S, et al.
    • Journal Title

      Br J Cancer 90

      Pages: 2059-2061

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-13214058
  • [Journal Article] Absence of c-kit gene mutations in gastrointestinal stromal tumors of neurofibromatosis type I patients.2004

    • Author(s)
      Kinoshita K, Hirota S, Isozaki K, Ohashi A, Nishida T, Kitamura Y, Shinomura Y, Matsuzawa Y.
    • Journal Title

      J Pathol 202(1)

      Pages: 80-85

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390363
  • [Journal Article] Different inhibitory effect of Imatinib on phosphorylation of MAPK and Akt, and cell proliferation in cells expressing different types of mutant PDGF receptor alpha.2004

    • Author(s)
      Ohashi A, Hirota S, et al.
    • Journal Title

      Int J Cancer 111

      Pages: 317-321

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-13214058
  • [Journal Article] Different inhibitory effect of Imatinib on phosphorylation of MAPK and Akt, and cell proliferation in cells expressing different types of mutant PDGF receptor alpha.2004

    • Author(s)
      Ohashi A, Kinoshita K, Isozaki K, Nishida T, Shinomura Y, Kitamura Y, Hirota S
    • Journal Title

      Int J Cancer 111

      Pages: 317-321

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370076
  • [Journal Article] Different inhibitory effect of Imatinib on phosphorylation of MAPK and Akt, and cell proliferation in cells expressing different types of mutant PDGF receptor alpha.2004

    • Author(s)
      Ohashi A, Hirota S, et al.
    • Journal Title

      Int J Cancer 111

      Pages: 317-321

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370076
  • [Journal Article] Different inhibitory effect of Imatinib on phosphorylation of MAPK and Akt, and cell proliferation in cells expressing different types of mutant PDGF receptor alpha.2004

    • Author(s)
      Ohashi A, Kinoshita K, Isozaki K, Nishida T, Shinomura Y, Kitamura Y, Hirota S
    • Journal Title

      Int.J Cancer 111

      Pages: 317-321

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390363
  • [Journal Article] Late resistance to imatinib therapy associated with a second KIT mutation in metastatic gastrointestinal stromal tumour.2004

    • Author(s)
      Wakai T, Kanda T, Hirota S, Ohashi A, Shirai Y, Hatakeyama K
    • Journal Title

      Br J Cancer 90

      Pages: 2059-2061

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13214058
  • [Journal Article] Absence of c-kit gene mutations in gastrointestinal stromal tumours of neurofibromatosis type I patients.2004

    • Author(s)
      Kinoshita K, Hirota S, et al.
    • Journal Title

      J Pathol 202

      Pages: 80-85

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-13214058
  • [Journal Article] Late resistance to imatinib therapy associated with a second KIT mutation in metastatic gastrointestinal stromal tumour.2004

    • Author(s)
      Wakai T, Kanda T, Hirota S, Ohashi A, Shirai Y, Hatakeyama K
    • Journal Title

      Br J Cancer 90

      Pages: 2059-2061

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370076
  • [Journal Article] Endoscopic ultrasonography guided fine needle aspiration biopsy in follow-up patients with gastrointestinal stromal tumors.2003

    • Author(s)
      Kinoshita K, Isozaki K, Tsutsui S, Kitamura S, Hiraoka S, Watabe K, Nakahara M, Nagasawa Y, Kiyohara T, Miyazaki Y, Hirota S, Nishida T, Shinomura Y, Matsuzawa Y
    • Journal Title

      Eur J Gastroenterol Hepatol 15

      Pages: 1189-1193

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13214058
  • [Journal Article] C-kit gene mutation at exon 17 or 13 is very rare in sporadic gastrointestinal stromal tumors.2003

    • Author(s)
      Kinoshita K, Isozaki K, Hirota S, Nishida T, Chen H, Nakahara M, Nagasawa Y, Ohashi A, Shinomura Y, Kitamura Y, Matsuzawa Y
    • Journal Title

      J Gastroenterol Hepatol. 18

      Pages: 147-151

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13214058
  • [Journal Article] Imatinib inhibits various types of activating mutant KIT found in gastrointestinal stromal tumors.2003

    • Author(s)
      Chen H, Isozaki K, Kinoshita K, Ohashi A, Shinomura Y, Matsuzawa Y, Kitamura. Y, Hirota S
    • Journal Title

      Int J Cancer. 105

      Pages: 130-135

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13214058
  • [Journal Article] C-kit gene mutation at exon 17 or 13 is very rare in sporadic gastrointestinal stromal tumors.2003

    • Author(s)
      Kinoshita K, Isozaki K, Hirota S, Nishida T, Chen H, Nakahara M, Nagasawa Y, Ohashi A, Shinomura Y, Kitamura Y, Matsuzawa Y
    • Journal Title

      J Gastroenterol Hepatol 18

      Pages: 147-151

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370076
  • [Journal Article] Gain-of-function mutations of platelet-derived growth factor receptor alpha gene in gastrointestinal stromal tumors.2003

    • Author(s)
      Hirota S, Ohashi A, Nishida T, Isozaki K, Kinoshita. K, Shinomura Y, Kitamura Y
    • Journal Title

      Gastroenterology 125

      Pages: 660-667

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13214058
  • [Journal Article] Familial gastrointestinial stromal tumors associated with dysphagia and novel type germline mutation of KIT gene.2003

    • Author(s)
      Hirota S, et al.
    • Journal Title

      Gastroenterology 122

      Pages: 1493-1499

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370076
  • [Journal Article] Gain-of-function mutations of platelet-derived growth factor receptor alpha gene in gastrointestinal stromal tumors.2003

    • Author(s)
      Hirota S, Ohashi A, Nishida T, Isozaki K, Kinoshita K, Shinomura Y, Kitamura Y
    • Journal Title

      Gastroenterology 125

      Pages: 660-667

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370076
  • [Journal Article] Gain-of-function mutations of platelet-derived growth factor receptor alpha gene in gastrointestinal stromal tumors.2003

    • Author(s)
      Hirota S, et al.
    • Journal Title

      Gastroenterology 125

      Pages: 660-667

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-13214058
  • [Journal Article] Imatinib inhibits various types of activating mutant KIT found in gastrointestinal stromal tumors.2003

    • Author(s)
      Chen H, Hirota S, et al.
    • Journal Title

      Int J Cancer 105

      Pages: 130-135

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-13214058
  • [Journal Article] Endoscopic ultrasonography guided fine needle aspiration biopsy in follow-up patients with gastrointestinal stromal tumors.2003

    • Author(s)
      Kinoshita K, Isozaki K, Tsutsui S, Kitamura S, Hiraoka S, Watabe K, Nakahara M, Nagasawa Y, Kiyohara T, Miyazaki Y, Hirota S, Nishida T, Shinomura Y, Matsuzawa Y
    • Journal Title

      Eur J Gastroenterol Hepatol 15

      Pages: 1189-1193

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370076
  • [Journal Article] Imatinib inhibits various types of activating mutant KIT found in gastrointestinal stromal tumors.2003

    • Author(s)
      Chen H, Isozaki K, Kinoshita K, Ohashi A, Shinomura Y, Matsuzawa Y, Kitamura Y, Hirota S
    • Journal Title

      Int J Cancer 105

      Pages: 130-135

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370076
  • [Journal Article] Gain-of-function mutations of platelet-derived growth factor receptor alpha gene in gastrointestinal stromal tumors.2003

    • Author(s)
      Hirota S, et al.
    • Journal Title

      Gastroenterology 125

      Pages: 660-667

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370076
  • [Journal Article] Polyclonal nature of diffuse proliferation of interstitial cells of Cajal in patients with familial and multiple gastrointestinal stromal tumours.2002

    • Author(s)
      Chen H, Hirota S, et al.
    • Journal Title

      Gut 51

      Pages: 793-796

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370076
  • [Journal Article] Polyclonal nature of diffuse proliferation of interstitial cells of Cajal in patients with familial and multiple gastrointestinal stromal tumours.2002

    • Author(s)
      Chen H, Hirota S, Isozaki K, Sun H, Ohashi A, Kinoshita K, O'Brien P, Kapusta L, Dardick I, Obayashi T, Okazaki T, Shinomura Y, Matsuzawa Y, Kitamura Y
    • Journal Title

      Gut. 51

      Pages: 793-796

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370076
  • [Journal Article] Familial gastrointestinial stromal tumors associated with dysphagia and novel type germline mutation of KIT gene.2002

    • Author(s)
      Hirota S, Nishida T, Isozaki K, Taniguchi M, Nishikawa K, Ohashi A, Takabayashi A, Obayashi T, Okuno T, Kinoshita K, Chen H, Shinomura Y, Kitamura Y
    • Journal Title

      Gastroenterology 122

      Pages: 1493-1499

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370076
  • [Journal Article] Improvement of psoriasis during imatinib therapy in a patient with a metastatic gastrointestinal stromal tumour.2002

    • Author(s)
      Miyagawa S, Fujimoto H, Ko S, Hirota S, Kitamura Y
    • Journal Title

      Br J Dermatol. 147

      Pages: 406-407

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370076
  • [Journal Article] Polyclonal nature of diffuse proliferation of interstitial cells of Cajal in patients with familial and multiple gastrointestinal stromal tumours.2002

    • Author(s)
      Chen H, Hirota S, et al.
    • Journal Title

      Gut 51

      Pages: 793-796

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-13214058
  • [Journal Article] Improvement of psoriasis during imatinib therapy in a patient with a metastatic gastrointestinal stromal tumour.2002

    • Author(s)
      Miyagawa S, Fujimoto H, Ko S, Hirota S. Kitamura Y
    • Journal Title

      Br J Dermatol. 147

      Pages: 406-407

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13214058
  • [Journal Article] Polyclonal nature of diffuse prolifera.tion of interstitial cells of Cajal in patients with familial and multiple gastrointestinal stromal tumours.2002

    • Author(s)
      Chen H, Hirota S.Isozaki K, Sun H, Ohashi A, Kinoshita K, O'Brien P, Kapusta L, Dardick I, Obayashi T, Okazaki T, Shinomura Y, Matsuzawa Y, Kitamura Y
    • Journal Title

      Gut. 51

      Pages: 793-796

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13214058
  • [Journal Article] Familial gastrointestinial stromal tumors associated with dysphagia and novel type germline mutation of KIT gene.2002

    • Author(s)
      Hirota, Nishida T, Isozaki K, Taniguchi M, Nishikawa K, Ohashi A, Takabayashi A, Obayashi T, Okuno T, Kinoshita K, Chen H, Shinomura Y, Kitamura Y
    • Journal Title

      Gastroenterology. 122

      Pages: 1493-1499

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13214058
  • [Journal Article] Pleomorphic phenotypes of gastrointestinal stromal tumors at metastatic sites with or without imatinib treatment.

    • Author(s)
      S akamoto K, Sakurai S, Kanda T, Sakuma Y, Hishima T, Hironaka M, Bamba T, Keira Y, Takano Y, Niki T, Hasegawa T, Hirota S.
    • Journal Title

      Cancer Sci. (In press)

    • NAID

      10026592688

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013082
  • [Journal Article] Pleomorphic phenotypes of gastrointestinal stromal tumors at metastatic sites with or without imatinib treatment

    • Author(s)
      S akamoto K, Sakurai S, Kanda T, Sakuma Y, Hishima T, Hironaka M, Bamba T, Keira Y, Takano Y, Niki T, Hasegawa T, Hirota S
    • Journal Title

      Cancer Sci (In press)

    • NAID

      10026592688

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590410
  • [Presentation] 皮膚に辺縁帯リンパ腫,リンパ節にT細胞リンパ腫を同時期に認めた1症例2023

    • Author(s)
      松田 育雄, 大西 麻由, 西浦 哲雄, 廣田 誠一
    • Organizer
      第63回日本リンパ網内系学会学術集会・総会
    • Data Source
      KAKENHI-PROJECT-18K07003
  • [Presentation] 扁桃を想起させる組織構築を示す胸腺癌の1例2022

    • Author(s)
      松田 育雄, 木原 多佳子, 中西 麻衣, 中込 奈美, 松尾 祥平, 廣田 誠一
    • Organizer
      第111回日本病理学会総会
    • Data Source
      KAKENHI-PROJECT-18K07003
  • [Presentation] A case of thymic carcinoma histologically reminiscent of palatine tonsil2022

    • Author(s)
      Ikuo Matsuda, Takako Kihara, Mai Nakanishi, Nami Nakagomi, Shohei Matsuo, Seiichi Hirota
    • Organizer
      第111回日本病理学会総会
    • Data Source
      KAKENHI-PROJECT-18K07003
  • [Presentation] 肉芽腫の目立つ肝臓・脾臓の稀なリンパ腫様病変2021

    • Author(s)
      松田 育雄, 吉安 可奈子, 河野 洋, 廣田 誠一
    • Organizer
      第110回日本病理学会総会
    • Data Source
      KAKENHI-PROJECT-18K07003
  • [Presentation] Hepatic and splenic granulomatous masses with marginal zone lymphoma-like lesions2020

    • Author(s)
      Ikuo Matsuda, Hiroshi Kono, Kanako Yoshiyasu, Seiichi Hirota
    • Organizer
      第82回日本血液学会学術集会
    • Data Source
      KAKENHI-PROJECT-18K07003
  • [Presentation] 皮膚筋炎患者に生じた膵・皮膚リンパ増殖性病変の1例2019

    • Author(s)
      松田育雄、森本麻衣、高田亮、松井聖、夏秋優、廣田誠一
    • Organizer
      第108回 日本病理学会総会 (2019年5月)
    • Data Source
      KAKENHI-PROJECT-18K07003
  • [Presentation] 皮膚筋炎患者に生じた膵・皮膚リンパ増殖性病変の1例2019

    • Author(s)
      松田 育雄, 森本 麻衣, 高田 亮, 夏秋 優, 松井 聖, 廣田 誠一
    • Organizer
      第108回日本病理学会総会
    • Data Source
      KAKENHI-PROJECT-18K07003
  • [Presentation] Pathology of Gastrointestinal stromal tumor.2017

    • Author(s)
      Seiichi Hirota
    • Organizer
      第89回日本胃癌学会総会
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H05166
  • [Presentation] gastrointestinal stromal tumor の病理学的研究から分子標的治療へ,2016

    • Author(s)
      廣田誠一
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-10-07
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H05166
  • [Presentation] Gastrointestinal stromal tumor (GIST) の病態解析と診断2016

    • Author(s)
      廣田誠一
    • Organizer
      第105回日本病理学会総会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2016-05-14
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H05166
  • [Presentation] GIST の起源と病態の解明.シンポジウム1(腫瘍病理学の真髄)2014

    • Author(s)
      廣田誠一
    • Organizer
      第103回病理学会総会
    • Place of Presentation
      広島
    • Year and Date
      2014-04-24
    • Data Source
      KAKENHI-PROJECT-23390094
  • [Presentation] KIT-Dup-Ser501Ala502変異を持つGISTの臨床病理学的特徴と変異分子の生物学的特徴の検討2014

    • Author(s)
      劉寧寧,井出良浩,梶本仙子,木村尚美,松田育雄,廣田誠一
    • Organizer
      第103回日本病理学会総会
    • Place of Presentation
      広島
    • Data Source
      KAKENHI-PROJECT-23390094
  • [Presentation] KIT-Dup-Ser501Ala502 変異を持つ GISTの臨床病理学的特徴と変異分子の生物学的特徴の検討2014

    • Author(s)
      劉寧寧, 井出良浩, 梶本仙子, 木村尚美, 松田育雄, 廣田誠一
    • Organizer
      第103回病理学会総会(示説)
    • Place of Presentation
      広島
    • Year and Date
      2014-04-24
    • Data Source
      KAKENHI-PROJECT-23390094
  • [Presentation] 初診時同時多発肝転移が見られ, 約9年の経過の後死亡した胃原発 GIST の一剖検例2014

    • Author(s)
      伊藤周明, 小賀厚徳, 飯田武, 近藤智子, 廣田誠一, 伊藤浩史
    • Organizer
      第103回病理学会総会(示説)
    • Place of Presentation
      広島
    • Year and Date
      2014-04-26
    • Data Source
      KAKENHI-PROJECT-23390094
  • [Presentation] GISTにおけるグローバルなDNAメチル化の解析2013

    • Author(s)
      松田 育雄, 廣田 誠一
    • Organizer
      第102回日本病理学会総会
    • Place of Presentation
      札幌
    • Data Source
      KAKENHI-PROJECT-23390094
  • [Presentation] 転移・再発性 GIST におけるイマチニブ治療と二次耐性-分子標的治療のモデル疾患として2013

    • Author(s)
      神田達夫, 石川卓, 廣田誠一
    • Organizer
      第54回日本臨床細胞学会, シンポジウム
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-23390094
  • [Presentation] GIST におけるグローバルな DNA メチル化の解析2013

    • Author(s)
      松田 育雄, 廣田 誠一
    • Organizer
      第102回日本病理学会総会
    • Place of Presentation
      札幌
    • Year and Date
      2013-06-08
    • Data Source
      KAKENHI-PROJECT-23390094
  • [Presentation] 病理学とGIST研究2012

    • Author(s)
      廣田誠一
    • Organizer
      第101回日本病理学会総会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-23390094
  • [Presentation] GIST における転写因子 ETV1 の発現について2012

    • Author(s)
      松田育雄, 廣田誠一
    • Organizer
      第101回日本病理学会総会
    • Place of Presentation
      東京
    • Year and Date
      2012-04-26
    • Data Source
      KAKENHI-PROJECT-23390094
  • [Presentation] Germline に新たな c-kit 遺伝子変異が認められた多発 GIST の一例2012

    • Author(s)
      山ノ井一裕, 岸本浩史, 西田保則, 中村将人, 須藤素弘, 廣田誠一, 樋口佳代子
    • Organizer
      第101回日本病理学会総会
    • Place of Presentation
      東京
    • Year and Date
      2012-04-26
    • Data Source
      KAKENHI-PROJECT-23390094
  • [Presentation] GIST の分子標的治療と病理診断.系統的・剖検病理診断講習(分子標的療法と病理診断)2012

    • Author(s)
      廣田誠一
    • Organizer
      第101回日本病理学会総会
    • Place of Presentation
      東京
    • Year and Date
      2012-04-28
    • Data Source
      KAKENHI-PROJECT-23390094
  • [Presentation] GISTの分子標的治療と病理診断2012

    • Author(s)
      廣田誠一
    • Organizer
      第101回日本病理学会総会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-23390094
  • [Presentation] 切除不能・転移性GISTに対するイマチニブ治療:長期の耐容性と長期成績.パネルディスカッション「消化管GIST治療の准歩と長期予後」2012

    • Author(s)
      神田達夫、石川卓、廣田誠一
    • Organizer
      JDDW2012 (日本消化器外科学会)
    • Place of Presentation
      神戸国際展示場(神戸市)
    • Year and Date
      2012-10-11
    • Data Source
      KAKENHI-PROJECT-24591934
  • [Presentation] Pathology of gastrointestinal stromal tumours.2012

    • Author(s)
      Hirota S
    • Organizer
      202th Scientific Meeting of the Pathological Society of Great Britain & Ireland
    • Place of Presentation
      Sheffield, Great Britain
    • Invited
    • Data Source
      KAKENHI-PROJECT-23390094
  • [Presentation] 病理学と GIST 研究.病理学入門シリーズ 1(癌病理学)2012

    • Author(s)
      廣田誠一
    • Organizer
      第101回日本病理学会総会
    • Place of Presentation
      東京
    • Year and Date
      2012-04-26
    • Data Source
      KAKENHI-PROJECT-23390094
  • [Presentation] GISTの病態解明から分子標的治療への展開を振り返る-Patient Zeroから10年を迎えて-2011

    • Author(s)
      廣田誠一
    • Organizer
      第100回日本病理学会総会
    • Place of Presentation
      横浜(招待講演)
    • Year and Date
      2011-04-29
    • Data Source
      KAKENHI-PROJECT-23390094
  • [Presentation] イマチニブ治療増悪後の治療戦略一二次耐性腫瘍切除の位置付け2010

    • Author(s)
      鍾田達夫、廣田誠一、畠山勝義
    • Organizer
      JDDW2010
    • Place of Presentation
      横浜市
    • Year and Date
      2010-10-14
    • Data Source
      KAKENHI-PROJECT-21591694
  • [Presentation] イマチニブ治療増悪後の治療戦略-二次耐性腫瘍切除の位置付け.ワークショップ「GISTの基礎と臨床」2010

    • Author(s)
      神田達夫,廣田誠一,畠山勝義
    • Organizer
      JDDW2010
    • Place of Presentation
      横浜市
    • Year and Date
      2010-10-14
    • Data Source
      KAKENHI-PROJECT-21591694
  • [Presentation] GISTの分子標的治療とその基盤2009

    • Author(s)
      廣田誠一
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-23
    • Data Source
      KAKENHI-PROJECT-17013082
  • [Presentation] GIST治療における病理診断2009

    • Author(s)
      廣田誠一
    • Organizer
      第47回日本癌治療学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-23
    • Data Source
      KAKENHI-PROJECT-17013082
  • [Presentation] GISTイマチニブ治療における二次耐性腫瘍および奏効残存腫瘍切除の外科治療成績2009

    • Author(s)
      神田達夫、番場竹生、廣田誠一, 他
    • Organizer
      第71回日本臨床外科学会総会
    • Place of Presentation
      京都市
    • Year and Date
      2009-11-19
    • Data Source
      KAKENHI-PROJECT-21591694
  • [Presentation] GISTの診断と治療2009

    • Author(s)
      廣田誠一
    • Organizer
      第47回日本癌治療学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-23
    • Data Source
      KAKENHI-PROJECT-17013082
  • [Presentation] KIT-Asp820Tyr変異を持つ家族性多発性GIST家系のモデルマウスの作成2008

    • Author(s)
      伊藤敬, 中井紀博, 新長真由美, 松田育雄, 塚本吉胤, 羽尾裕之, 廣田誠一
    • Organizer
      第97回日本病理学会総会
    • Place of Presentation
      金沢
    • Year and Date
      2008-05-15
    • Data Source
      KAKENHI-PROJECT-17013082
  • [Presentation] Detection of cis-mutations in the activation loop of the KIT gene in sunitinib-resistant gastrointestinal stromal tumors.2008

    • Author(s)
      T. Nishida. T. Takahashi, K. Nakajima, A. Nishitani, S. Hirota
    • Organizer
      44th ASCO Chicago
    • Place of Presentation
      Illinois
    • Data Source
      KAKENHI-PROJECT-19390349
  • [Presentation] KIT-Asp820Tyr変異を持つ家族性多発性GIST家系のモデルマウスの作成2008

    • Author(s)
      伊藤敬, 中井紀博, 新長真由美, 松田育雄, 塚本吉胤, 羽尾裕之, 廣田誠一
    • Organizer
      第97回日本病理学会総会
    • Place of Presentation
      金沢
    • Year and Date
      2008-05-15
    • Data Source
      KAKENHI-PROJECT-19590410
  • [Presentation] mouse model of human GIST2008

    • Author(s)
      Hirota S
    • Organizer
      2008 Korean GIST Multidisciplinary Symposium
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2008-11-29
    • Data Source
      KAKENHI-PROJECT-19590410
  • [Presentation] A mouse model of human GIST.2008

    • Author(s)
      Hirota S
    • Organizer
      2008 Korean GIST Multidisciplinary Symposium
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2008-11-29
    • Data Source
      KAKENHI-PROJECT-19590410
  • [Presentation] A mouse model of human GIST2008

    • Author(s)
      Hirota S
    • Organizer
      2008 Korean GIST Multidisciplinary Symposium
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2008-11-29
    • Data Source
      KAKENHI-PROJECT-17013082
  • [Presentation] Aberrant Glycosylation in Juvenile Gastrointestinal Stromal Tumors.2008

    • Author(s)
      T Nishida, T Takahashi, Yo Souma, S Hirota, T Naka
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-19390349
  • [Presentation] A mouse model of human GIST.2008

    • Author(s)
      Hirota S
    • Organizer
      2008 Korean GIST Multidisciplinary Symposium
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2008-11-29
    • Data Source
      KAKENHI-PROJECT-19590411
  • [Presentation] etection of cis-mutations in the activation loop of the KIT gene in sunitinib-resistant gastrointestinal stromal tumors.2008

    • Author(s)
      NishidaT. T Takahashi, K Nakajima, A Nishitani, S Hirota
    • Organizer
      2008 ASCO Annual Meeting
    • Place of Presentation
      Chicago
    • Data Source
      KAKENHI-PROJECT-19390349
  • [Presentation] Correlative study and future perspectives in GIST treatment.2008

    • Author(s)
      NishidaT. T Takahashi, S Hirota
    • Organizer
      第80回日本胃癌学会総会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-19390349
  • [Presentation] A mouse model of human multiple GIST family with KIT-Asp820Tyr mutation generated by knock-in strategy.2008

    • Author(s)
      N akai N, Hirota S, et, al.
    • Organizer
      DDW
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2008-05-19
    • Data Source
      KAKENHI-PROJECT-17013082
  • [Presentation] A mouse model of human multiple GIST family with KIT-Asp820Tyr mutation generated by knock-in strategy2008

    • Author(s)
      N akai N, Hirota S, et al
    • Organizer
      DDW
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2008-05-19
    • Data Source
      KAKENHI-PROJECT-19590410
  • [Presentation] Impact and resistance to Imatinib on Advanced gastric Gastrointestinal Stromal Tumor.2007

    • Author(s)
      NishidaT. Takahashi T. Nakajima K. Doki Y. Monden M. Hirota S
    • Organizer
      The International College of Surgeons
    • Place of Presentation
      Kyoto
    • Data Source
      KAKENHI-PROJECT-19390349
  • [Presentation] 若年発症型GISTにおける腫瘍化シグナルとKITの検討2007

    • Author(s)
      高橋剛、中島清一、西谷暁子、北川透、種村匡弘、野村昌哉、廣田誠一、澤芳樹、西田俊朗
    • Organizer
      日本外科学会定期学術集会(107)
    • Place of Presentation
      大阪
    • Data Source
      KAKENHI-PROJECT-19390349
  • [Presentation] Gastrointestinal Stromal Tumor-molecular pathogenesis and target therapy-.2007

    • Author(s)
      NishidaT. Doki Yuichiro. Hirota S
    • Organizer
      66th Annual Meeting of the Japanese Cancer Association(66)
    • Place of Presentation
      Yokohama
    • Data Source
      KAKENHI-PROJECT-19390349
  • [Presentation] Role of Preoperative and Postoperative Imatinib on Advanced Gastrointestinal Stromal Tumor.2007

    • Author(s)
      NishidaT. Takahashi T. Hirota S
    • Organizer
      2nd WORLD CONGRESS OF THE INTERNATIONAL SOCIETY OF SURGERY ISS/SIC(42)
    • Place of Presentation
      Montreal
    • Data Source
      KAKENHI-PROJECT-19390349
  • 1.  KITAMURA Yukihiko (70028520)
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  • 2.  KASUGAI Tsutomu (80214310)
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  • 4.  TSUJIMURA Tohru (20227408)
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