Hisaeda Hajime 久枝一

… Alternative Names

HISAEDA Hajime 久枝一

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Researcher Number	50243689
Other IDs
External Links
Affiliation (Current)	2025: 国立健康危機管理研究機構, 国立感染症研究所寄生動物部, 部長 2025: 群馬大学, 大学院医学系研究科, 非常勤講師
Affiliation (based on the past Project Information) *help	2016 – 2023: 国立感染症研究所, 寄生動物部, 部長 2016: 群馬大学, 大学院医学系研究科, 教授 2012 – 2015: 群馬大学, 医学(系)研究科(研究院), 教授 2010: 群馬大学, 医学研究科, 教授 2009 – 2010: Gunma University, 大学院・医学系研究科, 教授 … More 2007 – 2010: Kyushu University, Grad. Sch. of Med. Sci., Associate Professor 2009: 群馬大学, 医学研究院, 教授 2007 – 2008: 九州大学, 大学院・医学研究院, 准教授 2005 – 2006: 九州大学, 医学研究院, 助教授 2005 – 2006: 九州大学, 大学院医学研究院, 助教授 2003 – 2005: 九州大学, 大学院・医学研究院, 助教授 2002: 九州大学, 大学院・医学研究院, 講師 1998: 徳島大, 医学部, 助手 1994 – 1997: 徳島大学, 医学部, 助手 1993: 徳島大学, 医学部・寄生虫学講座, 助手 Less
Review Section/Research Field	Principal Investigator 寄生虫学(含医用動物学) / Biological Sciences / Parasitology (including sanitary zoology) / Parasitology (including Sanitary zoology) / Basic Section 49040:Parasitology-related / Immunology / Biological Sciences Except Principal Investigator 寄生虫学(含医用動物学) / Parasitology (including Sanitary zoology) / Biological Sciences / Hematology / Medical sociology
Keywords	Principal Investigator マラリア / 免疫回避 / 制御性T細胞 / CD8T細胞 / 樹状細胞 / TLR9 / マラリア原虫 / 熱ショック蛋白質 / ウガンダ / 腸内細菌 … More / 病原性 / 腸管寄生性蠕虫 / 防御免疫 / 宿主病原体相互関係 / 免疫抑制 / 宿主寄生体相互関係 / マクロファージ / 感染防御免疫 / トキソプラズマ原虫 / 宿主ー寄生体相互関係 / マウスモデル / バイオーマーカー / 重症化因子 / MPO / 合併症 / バイオマーカー / 脳マラリア / 腸管内寄生虫 / 赤芽級 / CD8Ｔ細胞 / フォスファチジルセリン / ワクチンモデル開発 / プロテアソーム / 宿主病原体相互作用 / 赤芽球 / CD8 T細胞 / Toll-like receptor 9 / dendritic cells / regulatory T cells / immune evasion / malaria / IDO / トリプトファン代謝 / 衛生仮説 / 寄生虫症 / 腸内細菌叢 / 腸管寄生線虫 / 免疫制御 / 腸管寄生性線虫 / ミトコンドリア / ミューテーター / アピコプラスト / 寄生適応 / 赤血球 / 制御性 T 細胞 / 抑制性T細胞 / ワクチン開発 / アポトーシス / トキソプラズマ / HSP65 / 感染宿主種特異性 … More Except Principal Investigator DNAワクチン / マラリア / 原虫感染免疫 / 熱ショック蛋白質 / トキソプラズマ / 病原性 / CD8^+T細胞 / 遺伝子銃 / HSP65 / γδT細胞 / 感染防御 / リーシュマニア / ユビキチンプロテアソーム系 / ユビキチンプロテアソーム / PA28ノックアウトマウス / プロテアソーム阻害剤 / ユビキチン融合遺伝子 / SAG-1 / 細胞内寄生原虫 / アポトーシス / T細胞 / HSP90 / αβT細胞 / エスケープ機構 / 原虫 / proteasome inhibitor / proteasome KO mice / CD8^+ T cell / ubiquitin-proteasome / ubiquitin / gene gun / DNA vaccine / intracellular protozoa / プロテアソームKOマウス / ユビキチン遺伝子 / 細胞内寄生病原虫 / Resistance to infection / delta T cells / gamma / Heat shock proteins / Protection to protozoa infection / Toxoplasma gondii / NKT細胞 / マクロファージ / HSP / 細胞性寄生性 / 原虫感染 / 感染抵抗性 / γδ型T細胞 / 原虫感染防御 / Protective immunity / gammadelta T cell / Virulence / Leishmania / Toxoplasma / Protozoan infection / Heat shock protein / 防御免疫 / マラリア原虫 / サラセミア / 赤血球 / microRNA / 下痢 / バングラデシュ / 赤痢アメーバ / コホート研究 / ゲノム疫学 / 赤痢アメーバ症 / 感染症 / 南アジア / 肝臓内型 / 赤血球内型 / マラリア強毒株 / プロテアソーム / ユビキチン / 3LL肺癌 / 抗腫瘍免疫 / MUT1遺伝子 / 3LL 肺癌 / DNA ワクチン / 抗腫傷免疫 / レジオネラ / O157 / 新型インフルエンザ / SARS / 医学教育 / 鳥インフルエンザ / エマージング感染症 / サイトカイン / MAP-1 / SERA / 分子シャペロン / Tリンパ球 / カテプシンB / システインプロテアーゼ Less

Identification of host pathogenic factors responsible for development of cerebral malariaPrincipal Investigator
- Principal Investigator
  
  Hisaeda Hajime
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49040:Parasitology-related
- Research Institution
  National Institute of Infectious Diseases
Host-parasite interaction in eythroblastic infection during malariaPrincipal Investigator
- Principal Investigator
  
  Hisaeda Hajime
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Parasitology (including sanitary zoology)
- Research Institution
  National Institute of Infectious Diseases
  Gunma University
Analyses of interaction between malaria and intestinal microbiota in patients in UgandaPrincipal Investigator
- Principal Investigator
  
  Hisaeda Hajime
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Parasitology (including sanitary zoology)
- Research Institution
  National Institute of Infectious Diseases
  Gunma University
Effects of intestinal microbita on immune modulation during helminthic infections and its application to prevention of inflammatory disordersPrincipal Investigator
- Principal Investigator
  
  HISAEDA Hajime
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Immunology
- Research Institution
  Gunma University
次世代オルガネラ学の革新的ツールである超高速進化型マラリア原虫の創成Principal Investigator
- Principal Investigator
  
  久枝一
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Gunma University
マラリアにおける免疫回避に関わる宿主寄生体相互作用の解析Principal Investigator
- Principal Investigator
  
  久枝一
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Gunma University
ヒト赤血球microRNAによるマラリア感染機構の調節
- Principal Investigator
  
  梅村創
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Hematology
- Research Institution
  Kyushu University
Molecular basis of immune evasion of malaria parasitesPrincipal Investigator
- Principal Investigator
  
  HISAEDA Hajime
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Parasitology (including Sanitary zoology)
- Research Institution
  Kyushu University
The genomic epidemiology and immunological cohort study on amoebiasis in South Asia
- Principal Investigator
  
  HAMANO Shinjiro
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Parasitology (including Sanitary zoology)
- Research Institution
  Kyushu University
マラリア原虫の病原性を決定する免疫抑制メカニズムの解明Principal Investigator
- Principal Investigator
  
  久枝一
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyushu University
DNA vaccine targeting both liver and blood stage of virulent strain Plasmodium
- Principal Investigator
  
  HAMANO Shinjiro, 姫野国祐
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Parasitology (including Sanitary zoology)
- Research Institution
  Kyushu University
ユピキチンプロテアソーム系の応用による2段階肺癌遺伝子ワクチン
- Principal Investigator
  
  姫野國祐
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyushu University
Analyses for immune evasion by malaria parasitesPrincipal Investigator
- Principal Investigator
  
  HISAEDA Hajirme
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Parasitology (including Sanitary zoology)
- Research Institution
  Kyushu University
エマージング感染症のための教育用プログラムの開発
- Principal Investigator
  
  藤井潤
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Medical sociology
- Research Institution
  Kyushu University
マラリアにおける制御性T細胞による宿主免疫抑制のメカニズムの解析Principal Investigator
- Principal Investigator
  
  久枝一
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyushu University
ユビキチンプロテアソーム系の応用による細胞内寄生原虫に対するDNAワクチンの開発
- Principal Investigator
  
  姫野國祐
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyushu University
Development of DNA vaccine against intracellular protozoa bored on ubiquitin-proteasome system
- Principal Investigator
  
  HIMENO Kunisuke
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Parasitology (including Sanitary zoology)
- Research Institution
  KYUSHU UNIVERSITY
マラリアワクチン開発の基礎的研究Principal Investigator
- Principal Investigator
  
  久枝一
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  寄生虫学(含医用動物学)
- Research Institution
  Kyushu University
マラリア原虫感染における原虫および宿主の熱ショック蛋白質の機能
- Principal Investigator
  
  姫野國祐
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokushima
分子シャペロンHSP65による原虫感染宿主細胞のアポトーシスの抑制と感染防御
- Principal Investigator
  
  姫野國祐
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokushima
熱ショック蛋白質の細胞内寄生性原虫によるアポトーシスの抑制機能Principal Investigator
- Principal Investigator
  
  久枝一
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  寄生虫学(含医用動物学)
- Research Institution
  The University of Tokushima
遺伝子鏡を用いたマラリア感染に対するDNAワクチネーションの基礎的研究
- Principal Investigator
  
  酒井敲 (酒井徹)
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  寄生虫学(含医用動物学)
- Research Institution
  The University of Tokushima
マラリア原虫の病原性に係わる分子としての熱ショック蛋白質の機能
- Principal Investigator
  
  姫野國祐
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokushima
システインプロテアーゼによるリーシュマニア感染T細胞機能的分化の新しい制御理論
- Principal Investigator
  
  姫野國祐
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  寄生虫学(含医用動物学)
- Research Institution
  The University of Tokushima
Role of Heat Shock Protein against Protozoan Infection
- Principal Investigator
  
  HIMENO Kunisuke
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Field
  
  寄生虫学(含医用動物学)
- Research Institution
  University of Tokushima
網内系寄生性原虫のエスケープ・感染防御に係わる熱ショック蛋白質の機能と発現機序Principal Investigator
- Principal Investigator
  
  久枝一
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  寄生虫学(含医用動物学)
- Research Institution
  The University of Tokushima
原虫の毒力の差による熱ショック蛋白質発現の相違と原虫エスケープ・宿主防御機構
- Principal Investigator
  
  HIMENO Kunisuke
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokushima
Role of HSP65 in host protection against intracellular protozoan infection.
- Principal Investigator
  
  HIMENO Kunisuke
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  寄生虫学(含医用動物学)
- Research Institution
  Tokushima University
トキソプラズマ感染抵抗性における宿主特異性と熱ショック蛋白質の発現の関与Principal Investigator
- Principal Investigator
  
  久枝一
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  寄生虫学(含医用動物学)
- Research Institution
  The University of Tokushima

[Book] 人獣共通感染症2016
- Author(s)
  久枝一
- Total Pages
  6
- Publisher
  医薬ジャーナル社
- Data Source
  KAKENHI-PROJECT-15K08441
[Book] 人獣共通感染症2016
- Author(s)
  久枝一
- Total Pages
  6
- Publisher
  医薬ジャーナル社
- Data Source
  KAKENHI-PROJECT-15H05274
[Journal Article] Histone H3.3 variant plays a critical role on zygote-to-oocyst development in malaria parasites2024
- Author(s)
  2.Tateishi YS, Araki T, Kawai S, Koide S, Umeki Y, Imai T, Saito-Nakano Y, Kikuchi M, Iwama A, Hisaeda H, Coban C, Annoura T
- Journal Title
  
  Parasitology International
  
  Volume: 100 Pages: 102856-102856
- DOI
  10.1016/j.parint.2024.102856
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07530, KAKENHI-PROJECT-22K16298
[Journal Article] Ultrasensitive malaria detection system for Anopheles mosquito field surveillance using droplet digital PCR2024
- Author(s)
  1.Araki T, Koyama A, Yoshimura H, Arai A, Kawai S, Sekizawa S, Umeki, Saito-Nakano Y, Imai T, Okamoto M, Sato M, Thabthimthong W, Kemthong T, Hisaeda H, Malaivijitnond S, Annoura T
- Journal Title
  
  Parasitology International
  
  Volume: 101 Pages: 102891-102891
- DOI
  10.1016/j.parint.2024.102891
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07530, KAKENHI-PROJECT-19KK0205
[Journal Article] Prevalence and metronidazole resistance of Trichomonas vaginalis among Japanese women in 20212023
- Author(s)
  Saito-Nakano Y, Umeki Y, Shimokawa C, Kobayashi K, Hashimoto K, Takada T, Makii C, Hasebe R, Yoshida Y, Nakajima R, Kobayashi S, Hisaeda H.
- Journal Title
  
  IJID Reg
  
  Volume: 7 Pages: 130-135
- DOI
  10.1016/j.ijregi.2023.02.007
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07530, KAKENHI-PROJECT-22K07050, KAKENHI-PROJECT-19K07531, KAKENHI-PROJECT-22K07049
[Journal Article] Human gut microbiota and its metabolites impact immune responses in COVID-19 and its complications2022
- Author(s)
  Nagata N, Takeuchi T, Masuoka H, Aoki R, Ishikane M, Iwamoto N, Sugiyama M, Suda W, Nakanishi Y, Terada-Hirashima J, Kimura M, Nishijima T, Inooka H, Miyoshi-Akiyama T, Kojima Y, Shimokawa C, Hisaeda H, Zhang F, Yeoh YK, Ng SC, Uemura N, Itoi T, Mizokami M, Kawai T, Sugiyama H, Ohmagari N, Ohno H.
- Journal Title
  
  Gastroenterology
  
  Volume: 164 Issue: 2 Pages: 272-288
- DOI
  10.1053/j.gastro.2022.09.024
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07530, KAKENHI-PLANNED-22H05058, KAKENHI-PROJECT-19K16682, KAKENHI-PROJECT-22K07049
[Journal Article] Live vaccination with blood-stage Plasmodium yoelii 17XNL prevents the development of experimental cerebral malaria2022
- Author(s)
  Imai T, Ngo-Thanh H, Suzue K, Shimo A, Nakamura A, Horiuchi Y, Hisaeda H, Murakami T.
- Journal Title
  
  Vaccines (Basel)
  
  Volume: 10 Issue: 5 Pages: 762-762
- DOI
  10.3390/vaccines10050762
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07530
[Journal Article] Malaria parasite evades mosquito immunity by glutamine cyclase-mediated post translational protein modification2022
- Author(s)
  Kolli SK, Molina-Cruz A, Araki T, Geurten FJA, Ramesar J, Chevalley-Maurel S, Kroeze HJ, Bezemer S, de Korne C, Withers R, Raytselis N, El Hebieshy AF, Kim RQ, Child MA, Kakuta S, Hisaeda H, Kobayashi H, Annoura T, Hensbergen PJ, Franke-Fayard BM, Barillas-Mury C, Scheeren FA, Janse CJ.
- Journal Title
  
  Proc Natl Acad Sci U S A
  
  Volume: 119 Issue: 35
- DOI
  10.1073/pnas.2209729119
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07530
[Journal Article] Long-term acrylamide exposure exacerbates brain and lung pathology in a mouse malaria model.2021
- Author(s)
  2.Ngo-Thanh H, Thuy TD, Suzue K, Kamitani W, Yokoo H, Isoda K, Shimokawa C, Hisaeda H, Imai T
- Journal Title
  
  Food Chem Toxicol.
  
  Volume: 151
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07530
[Journal Article] Suppression of systemic lupus erythematosus in NZBWF1 mice infected with Hymenolepis microstoma.2020
- Author(s)
  OLIA A, SHIMOKAWA C, IMAI T, SUZUE K, HISAEDA H.
- Journal Title
  
  Parasitology International.
  
  Volume: 76 Pages: 102057-102057
- DOI
  10.1016/j.parint.2020.102057
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07530, KAKENHI-PROJECT-19K16682
[Journal Article] Suppression of systemic lupus erythematosus in NZBWF1 mice infected with Hymenolepis microstoma2020
- Author(s)
  Olia A, Shimokawa C, Imai T, Suzue K, Hisaeda H.
- Journal Title
  
  Parasito
  
  Volume: 76
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07530
[Journal Article] Three-dimensional electron microscopy analysis reveals endopolygeny-like nuclear architecture segregation in Plasmodium oocyst development.2020
- Author(s)
  ARAKI T, KAWAI S, KAKUTA S, KOBAYASHI H, UMEKI Y, SAITO-NAKANO Y, SASAKI T, NAGAMUNE K, YASUTOMI Y, NOZAKI T, FRANKE-FAYARD B, KHAN SM, HISAEDA H, ANNOUNRA T.
- Journal Title
  
  Parasitology International.
  
  Volume: 76 Pages: 102034-102034
- DOI
  10.1016/j.parint.2019.102034
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07530, KAKENHI-PROJECT-17H04079
[Journal Article] Blood-cerebrospinal fluid barrier: another site disrupted during experimental cerebral malaria caused by Plasmodium berghei ANKA2020
- Author(s)
  Ngo-Thanh H, Sasaki T, Suzue K, Yokoo H, Isoda K, Kamitani W, Shimokawa C, Hisaeda H, Imai T
- Journal Title
  
  International Journal of Parasitology
  
  Volume: 50 Pages: 1167-1175
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07530
[Journal Article] CD8+ regulatory T cells are critical in prevention of autoimmune-mediated diabetes2020
- Author(s)
  3.Shimokawa C, Kato T, Takeuchi T, Ohshima N, Furuki T, Ohtsu Y, Suzue K, Imai T, Obi S, Olia A, Izumi T, Sakurai M, Arakawa H, Ohno H, Hisaeda H
- Journal Title
  
  Nature Communications
  
  Volume: 11 Issue: 1 Pages: 1922-1922
- DOI
  10.1038/s41467-020-15857-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07530, KAKENHI-PROJECT-19K16682, KAKENHI-PROJECT-19H01030
[Journal Article] Potential and limitations of cross-protective vaccine against malaria by blood-stage naturally attenuated parasites2020
- Author(s)
  Imai T, Suzue K, Ngo-Thanh H, Shimokawa C, Hisaeda H
- Journal Title
  
  Vaccines
  
  Volume: 8 Issue: 3 Pages: 375-375
- DOI
  10.3390/vaccines8030375
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07530, KAKENHI-PROJECT-19K16682
[Journal Article] IL-33 is essential to prevent high fat diet-induced obesity in mice infected with an intestinal helminth2020
- Author(s)
  Obi S, Shimokawa C, Katsuura M, Olia A, Imai T. Suzue K, Hisaeda H
- Journal Title
  
  Parasite Immunology
  
  Volume: 42
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07530
[Journal Article] IL-33 is essential to prevent high fat diet-induced obesity in mice infected with an intestinal helminth.2020
- Author(s)
  OBI S, SHIMOKAWA C, KATUURA M, OLIA A, IMAI T, SUZUE K, HISAEDA H.
- Journal Title
  
  Parasite Immunology.
  
  Volume: 記載なし
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07530
[Journal Article] Fluctuations of spleen cytokine and blood lactate, importance of cellular immunity in host defense against blood stage malaria Plasmodium yoelii.2019
- Author(s)
  IMAI T, SUZUE K, NGO-THANH H, ONO S, ORITA W, SUZUKI H, SHIMOKAWA C, OLIA A, OBI S, TANIGUCHI T, ISHIDA H, van KAER L, MURATA S, TANAKA K, HISAEDA H.
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 10
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07530
[Journal Article] Suppression of obesity by an intestinal helminth through interactions with intestinal microbiota.2019
- Author(s)
  Shimokawa C, Obi S, Shibata M, Olia A, Imai T, Suzue K, Hisaeda H.
- Journal Title
  
  Infection and Immunity
  
  Volume: 印刷中 Issue: 6
- DOI
  10.1128/iai.00042-19
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08441, KAKENHI-PROJECT-15H05274, KAKENHI-PROJECT-19K07530, KAKENHI-PROJECT-19K16682, KAKENHI-PROJECT-19K21254
[Journal Article] Escherichia coli mediated resistance of Entamoeba histolytica to oxidative stress is triggered by oxaloacetate.2018
- Author(s)
  Shaulov Y, Shimokawa C, Trebicz-Geffen M, Nagaraja S, Methling K, Lalk M, Weiss-Cerem L, Lamm AT, Hisaeda H, Ankri S.
- Journal Title
  
  PLoS Pathongen
  
  Volume: 14 Issue: 10 Pages: e1007295-e1007295
- DOI
  10.1371/journal.ppat.1007295
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08441, KAKENHI-PROJECT-15H05274
[Journal Article] Intestinal Inflammation-Mediated Clearance of Amebic Parasites Is Dependent on IFN-γ2018
- Author(s)
  Shimokawa C, Senba M, Kobayashi S, Kikuchi M, Obi S, Olia A, Hamano S, Hisaeda H
- Journal Title
  
  Journal of Immunology
  
  Volume: 200 Issue: 3 Pages: 1101-1109
- DOI
  10.4049/jimmunol.1700806
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08441, KAKENHI-PROJECT-26305013, KAKENHI-PROJECT-17H04649, KAKENHI-PROJECT-15K08445, KAKENHI-PROJECT-26870849, KAKENHI-PROJECT-15H05278, KAKENHI-PROJECT-15H05274, KAKENHI-PROJECT-17H01684
[Journal Article] Mast Cells Are Crucial for Induction of Group 2 Innate Lymphoid Cells and Clearance of Helminth Infections.2017
- Author(s)
  Shimokawa C, Kanaya T, Hachisuka M, Ishiwata K, Hisaeda H, Kurashima Y, Kiyono H, Yoshimoto T, Kaisho T, Ohno H.
- Journal Title
  
  Immunity
  
  Volume: 46 Issue: 5 Pages: 863-874
- DOI
  10.1016/j.immuni.2017.04.017
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08441, KAKENHI-PROJECT-17K19568, KAKENHI-PROJECT-15H05274, KAKENHI-PUBLICLY-17H05799, KAKENHI-PROJECT-15H04865, KAKENHI-PROJECT-17H04088, KAKENHI-PROJECT-17K19575, KAKENHI-PROJECT-26870849, KAKENHI-PROJECT-16H06243
[Journal Article] A possible origin population of pathogenic intestinal nematodes, Strongyloides stercoralis, unveiled by molecular phylogeny2017
- Author(s)
  Nagayasu E, Aung MPPTHH, Hortiwakul T, Hino A, Tanaka T, Higashiarakawa M, Olia A, Taniguchi T, Win SMT, Ohashi I, Odongo-Aginya EI, Aye KM, Mon M, Win KK, Ota K, Torisu Y, Panthuwong S, Kimura E, Palacpac NMQ, Kikuchi T, Hirata T, Torisu S, Hisaeda H, Horii T, Fujita J, Htike WW, Maruyama H
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1 Pages: 4844-4844
- DOI
  10.1038/s41598-017-05049-x
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08441, KAKENHI-PROJECT-17K08809, KAKENHI-PROJECT-16K20952, KAKENHI-PROJECT-15H05274
[Journal Article] A transient resistance to blood-stage malaria in interferon-γ-deficient mice through impaired production of host cells preferred by malaria parasites2015
- Author(s)
  Okada H, Suzue K, Imai T, Taniguchi T, Shimokawa C, Onishi R, Hirata J, and Hisaeda H
- Journal Title
  
  Frontiers in Microbiology
  
  Volume: 6:600 Pages: 1-8
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08441
[Journal Article] A transient resistance to blood-stage malaria in interferon-γ-deficient mice through impaired production of host cells preferred by malaria parasites2015
- Author(s)
  Okada H, Suzue K, Imai T, Taniguchi T, Shimokawa C, Onishi R, Hirata J, and Hisaeda H
- Journal Title
  
  Frontiers in Microbiology
  
  Volume: 6:600 Pages: 1-8
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05274
[Journal Article] Cytotoxic activities of CD8+ T cells collaborate with macrophages to protect against blood-stage murine malaria2015
- Author(s)
  Imai T, Ishida H, Suzue K, Taniguchi T, Okada H, Shimokawa C, and Hisaeda H
- Journal Title
  
  eLIFE
  
  Volume: 4 Pages: 4-4
- DOI
  10.7554/elife.04232
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25670226, KAKENHI-PROJECT-26860276, KAKENHI-PROJECT-26870094
[Journal Article] Plasmodium berghei ANKA causes intestinal malaria associated with dysbiosis2015
- Author(s)
  Taniguchi T, Miyauchi E, Nakamura S, Hirai M, Suzue K, Imai T, Nomura T, Handa T, Okada H, Shimokawa C, Onishi R, Olia A, Hirata J, Tomita H, Ohno H, Horii T, Hisaeda H
- Journal Title
  
  Scientific Reports
  
  Volume: 5:15699 Issue: 1 Pages: 1-12
- DOI
  10.1038/srep15699
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08441, KAKENHI-PROJECT-15K08453, KAKENHI-PROJECT-15K08520, KAKENHI-PROJECT-26870094, KAKENHI-PROJECT-24249024, KAKENHI-PROJECT-15H05274, KAKENHI-PROJECT-13J05482, KAKENHI-PROJECT-24590501, KAKENHI-PROJECT-26850090, KAKENHI-PROJECT-26860276
[Journal Article] Generation of rodent malaria parasites with a high mutation rate by destructing proofreading activity of DNA polymerase δ.2014
- Author(s)
  Honma H, Hirai M, Nakamura S, Hakimi H, Kawazu S, Palacpac NM, Hisaeda H, Matsuoka H, Kawai S, Endo H, Yasunaga T, Ohashi J, Mita T, Horii T, Furusawa M, Tanabe K.
- Journal Title
  
  DNA Res
  
  Volume: 21 Issue: 4 Pages: 439-46
- DOI
  10.1093/dnares/dsu009
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-24112705, KAKENHI-PROJECT-24590501, KAKENHI-PROJECT-25670226
[Journal Article] Evaluating experimental cerebral malaria using oxidative stress indicator OKD48 mice.2014
- Author(s)
  Imai T, Iwawaki T, Akai R, Suzue K, Hirai M, Taniguchi T, Okada H, Hisaeda H.
- Journal Title
  
  Int J Parasitol.
  
  Volume: 44 Issue: 10 Pages: 681-685
- DOI
  10.1016/j.ijpara.2014.06.002
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-24112705, KAKENHI-PROJECT-24390049, KAKENHI-PROJECT-24590501, KAKENHI-PROJECT-25670226, KAKENHI-PROJECT-26860276, KAKENHI-PROJECT-26870094
[Journal Article] Generation of Rodent Malaria Parasites with a High Mutation Rate by Destructing Proofreading Activity of DNA Polymerase δ2014
- Author(s)
  Honma H, Hirai M, Nakamura S, Hakimi H, Kawazu SI, Palacpac NM, Hisaeda H, Matsuoka H, Kawai S, Endo H, Yasunaga T, Ohashi J, Mita T, Horii T, Furusawa M, Tanabe K.
- Journal Title
  
  DNA Res.
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-24117504
[Journal Article] Generation of Rodent Malaria Parasites with a High Mutation Rate by Destructing Proofreading Activity of DNA Polymerase δ.2014
- Author(s)
  Honma H, Hirai M, Nakamura S, Hakimi H, Kawazu SI, Palacpac NM, Hisaeda H, Matsuoka H, Kawai S, Endo H, Yasunaga T, Ohashi J, Mita T, Horii T, Furusawa M, Tanabe K.
- Journal Title
  
  DNA Res.
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25670226
[Journal Article] Resistance to Malaria by Enhanced Phagocytosis of Erythrocytes in LMP7-deficient Mice.2013
- Author(s)
  Duan X, Imai T, Chou B, Tu L, Himeno K, Suzue K, Hirai M, Taniguchi T, Okada H, Shimokawa C, Hisaeda H.
- Journal Title
  
  PLoS One.
  
  Volume: 8 Issue: 3 Pages: 1-9
- DOI
  10.1371/journal.pone.0059633
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-24112705, KAKENHI-PROJECT-24590501, KAKENHI-PROJECT-24790399, KAKENHI-PUBLICLY-24117504
[Journal Article] IL-23 protection against Plasmodium berghei infection in mice is partially dependent on IL-17 from macrophages2013
- Author(s)
  Ishida H, Imai T, Suzue K, Hirai M, Taniguchi T, Yoshimura A, Iwakura Y, Okada H, Suzuki T, Shimokawa C, and Hisaeda
- Journal Title
  
  Eur. J. Immunol.
  
  Volume: 43 Issue: 10 Pages: 2696-2706
- DOI
  10.1002/eji.201343493
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-24117504, KAKENHI-PROJECT-24220011, KAKENHI-PROJECT-24590501, KAKENHI-PROJECT-24790399, KAKENHI-PROJECT-25670226
[Journal Article] Species-specific immunity induced by infection with Entamoeba histolytica and Entamoeba moshkovskii in mice2013
- Author(s)
  Shimokawa, C., Culleton, R., Imai, T., Suzue, K., Hirai, M., Taniguchi, T., Kobayashi, S., Hisaeda, H., Hamano, S
- Journal Title
  
  PLoS One
  
  Volume: 8(11) Issue: 11 Pages: e82025-e82025
- DOI
  10.1371/journal.pone.0082025
- NAID
  120006986684
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23406009, KAKENHI-PUBLICLY-24117504, KAKENHI-PROJECT-24590501, KAKENHI-PROJECT-24590511, KAKENHI-PROJECT-24790399, KAKENHI-PROJECT-25670226
[Journal Article] CD8(+) T cell activation by murine erythroblasts infected with malaria parasites.2013
- Author(s)
  Imai T, Ishida H, Suzue K, Hirai M, Taniguchi T, Okada H, Suzuki T, Shimokawa C, Hisaeda H.
- Journal Title
  
  Sci Rep.
  
  Volume: 3 Issue: 1 Pages: 1572-1572
- DOI
  10.1038/srep01572
- NAID
  120006985954
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-24112705, KAKENHI-PROJECT-24590501, KAKENHI-PROJECT-24790399, KAKENHI-PUBLICLY-24117504
[Journal Article] A critical role for phagocytosis in resistance to malaria in iron-deficient mice.2011
- Author(s)
  Moriya-Matsuzaki C, Tu L, Ishida H, Imai T, Suzue K, Hirai M, Tetsutani K, Hamano S, Shimokawa C, Hisaeda H
- Journal Title
  
  Eur.J.Immunol. (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390121
[Journal Article] A critical role for phagocytosis in resistance to malaria in iron-deficient mice2011
- Author(s)
  Matsuzaki CM, Ishida H, Imai T, Suzue K, Hirai M, Tetsutani K, Hamano S, Shimonkawa C, Hisaeda H
- Journal Title
  
  Eur J Immunol
  
  Volume: (Epub ahead of print)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21659240
[Journal Article] Development of experimental cerebral malaria is independent of IL-23 and IL-17.2010
- Author(s)
  Ishida, H., Matsuzaki-Moriya, C., Imai, T., Yanagisawa, K., Nojima, Y., Suzue, K., Hirai, M., Iwakura, Y., Yoshimura, A., Hamano, S., Shimokawa, C., Hisaeda, H.
- Journal Title
  
  Biochem.Biophys.Res.Commun.
  
  Volume: 402 Pages: 790-795
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20406008
[Journal Article] Involvement of CD8^+ T cells in protective immunity against murine blood-stage infection with Plasmodium yoelii 17XL strain.2010
- Author(s)
  Imai T, Shen J, Chou B, Duan X, Tu L, Tetsutani K, Moriya C, Ishida H, Hamano S, Shimokawa C, Hisaeda H, Himeno K
- Journal Title
  
  Eur.J.Immunol. 40
  
  Pages: 1053-1061
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390121
[Journal Article] Involvement of CD8+ T cells in protective immunity against murine blood-stage infection with Plasmodium yoelii 17XL strain.2010
- Author(s)
  Imai, T., Shen, J., Chou, B., Duan, X., Tu, L., Tetsutani, K., Moriya, C., Ishida, H., Hamano, S., Shimokawa, C., Hisaeda, H., Himeno, K.
- Journal Title
  
  Eur.J.Immunol.
  
  Volume: 40 Pages: 1053-1061
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20406008
[Journal Article] Development of experimental cerebral malaria is independent of IL-23 and IL-172010
- Author(s)
  Hidekazu Ishida, Chikako Matsuzaki-Moriya, Takashi Imai, Kunio Yanagisawa, Yoshihisa Nojima, Kazutomo Suzue, Makoto Hirai, Yoichiro Iwakura, Akihiko Yoshimura, Shinjiro Hamano, Chikako Shimokawa, Hajime Hisaeda
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 402 Pages: 790-795
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21659240
[Journal Article] CD8+ T-cell Activation in Mice Injected with a Plasmid DNA Vaccine Encoding AMA-1 of the Reemerging Korean Plasmodium vivax2010
- Author(s)
  Hyo-Jin Kim, Bong-Kwang Jung, Jin-Joo Lee, Kyoung-Ho Pyo, Tae Yun Kim, Byung-il Choi, Tae Woo Kim, Hajime Hisaeda, Kunisuke Himeno, Eun-Hee Shin, Jong-Yil Chai
- Journal Title
  
  Korean J Parasitol
  
  Volume: 49 Pages: 85-90
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21659240
[Journal Article] Development of experimental cerebral malaria is independent of IL-23 and IL-17.2010
- Author(s)
  Ishida H, Matsuzaki-Moriya C, Imai T, Yanagisawa K, Nojima Y, Suzue K, Hirai M, Iwakura Y, Yoshimura A, Hamano S, Shimokawa C, Hisaeda H
- Journal Title
  
  Biochem. Biophys. Res.Commun. 402
  
  Pages: 790-795
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390121
[Journal Article] Development of experimental cerebral malaria is independent of IL-23 and IL-17.2010
- Author(s)
  Ishida H., Matsuzaki-Moriya C., Imai T., Yanagisawa K., Nojima Y., Suzue K., Hirai M., Iwakura Y., Yoshimura A., Hamano S., Shimokawa C., Hisaeda H.
- Journal Title
  
  Biochem.Biophys.Res.Commun. 402(4)
  
  Pages: 790-795
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20406008
[Journal Article] Involvement of CD8(+) T cells in protective immunity against murine blood-stage infection with Plasmodium yoelii 17XL strain.2010
- Author(s)
  Imai T., Shen J., Chou B., Duan X., Tu L., Tetsutani K., Moriya C., Ishida H., Hamano S., Shimokawa C., Hisaeda H., Himeno K.
- Journal Title
  
  Eur.J.Immunol. 40(4)
  
  Pages: 1053-1061
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20406008
[Journal Article] Critical role for immunoproteasome subunit LMP7 in the resistance of mice to Toxoplasma gondii infection.2009
- Author(s)
  Tu L, Moriya C, Imai T, Ishida H, Tetsutani K, Duan X, Murata S, Tanaka K, Shimokawa C, Hisaeda H, Himeno K
- Journal Title
  
  Eur.J.Immunol. 39
  
  Pages: 3385-3394
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390121
[Journal Article] Concurrent infection with Heligmosomoides polygyrus suppresses anti-Plasmodium yoelii protection partially by induction of CD4(+)CD25(+)Foxp3(+) Treg in mice.2009
- Author(s)
  Tetsutani K., Ishiwata K., Ishida H., Tu L., Torii M., Hamano S., Himeno K., Hisaeda H.
- Journal Title
  
  Eur J Immunol. 39(10)
  
  Pages: 2822-2830
- Data Source
  KAKENHI-PROJECT-20406008
[Journal Article] MicroRNA-Ago2 Complex in Mature Human Red Blood Cells2009
- Author(s)
  Tsukuru Umemura, Yuka Tanaka, Megumi Fujisaki, Shizuka Masaki, Hiromichi Shiotsu, Kanitta Srinoun, Suthat Fucharoen, Yasunobu Abe, Hisako Ichihara, Hiroyuki Toh, Hajime Hisaeda
- Journal Title
  
  Blood 114
  
  Pages: 1550-1550
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21659240
[Journal Article] Concurrent infection with Heligmosomoides polygyrus suppresses anti-Plasmodium yoelii protection partially by induction of CD4^+CD25^+Foxp3^+ Treg in mice.2009
- Author(s)
  Tetsutani K, Ishiwata K, Ishida H, Tu L, Torii M, Hamano S, Himeno K, Hisaeda H
- Journal Title
  
  Eur.J.Immunol. 39
  
  Pages: 2822-2830
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390121
[Journal Article] Malaria parasites require TLR9 signaling for immune evasion by activating regulatory T cells2008
- Author(s)
  Hisaeda, H., et. al.
- Journal Title
  
  The Journal of Immunology 180
  
  Pages: 2496-2503
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19041056
[Journal Article] Antigen-specific CD8+T cells induced by the ubiquitin fusion degradation pathway.2008
- Author(s)
  Imai T, Duan X, Hisaeda H, Himeno K.
- Journal Title
  
  Biochem Biophys Res Commun 365
  
  Pages: 758-63
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590429
[Journal Article] Malaria parasites require TLR9 signaling for immune evasion by activating regulatory T cells.2008
- Author(s)
  Hisaeda H, Tetsutani K, Imai T, Moriya C, Tu L, Hamano S, Duan X, Chou B, Ishida H, Aramaki A, Shen J, Ishii KJ, Coban C, Akira S, Takeda K, Yasutomo K, Torii M, Himeno K.
- Journal Title
  
  J Immunol 180
  
  Pages: 2496-503
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590429
[Journal Article] Malaria parasites require TLR9 signaling for immune evasion by activating regulatory T Cells.2008
- Author(s)
  Hisaeda H., Tetsutani K., Imai T., Moriya C., Tu L., Hamano S., Duan X., Chou B., Ishida H., Aramaki A., Shen J., Ishii K.J., Coban C., Akira S., Takeda K., Yasutomo K., Torii M., Himeno K.
- Journal Title
  
  J.Immunol. 180
  
  Pages: 2496-2503
- Data Source
  KAKENHI-PROJECT-20406008
[Journal Article] Critical contribution of immunoproteasomes in the in duction of protective immunity against Trruzi in mice vaccinated with a plasmid encoding a CTL epitope fused to green fluorescence protein.2008
- Author(s)
  Chou B, Hisaeda H, Shen J, Duan X, Imai T, Tu L, Murata S, Tanaka K, Himeno K.
- Journal Title
  
  Microbes Infect 10
  
  Pages: 241-50
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590429
[Journal Article] Malaria parasites require TLR9 signaling for immune evasion by activating regulatory T cells.2008
- Author(s)
  Hisaeda H., et al.
- Journal Title
  
  The Journal of Immunology. 180
  
  Pages: 2496-2503
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390121
[Journal Article] Concurrent infection with Heligmosomoides polygyrus modulates murine host response against Plasmodium berghei ANKA infection2008
- Author(s)
  Tetsutani K, Ishiwata K, Torii M, Hamano S, Hisaeda H, Himeno K
- Journal Title
  
  Am J Trop Med Hyg 79(6)
  
  Pages: 819-22
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590429
[Journal Article] Concurrent infection with Heligmosomoides polygyrus modulates murine host response against Plasmodium berghei ANKA infection.2008
- Author(s)
  Tetsutani K, Ishiwata K, Torii M, Hamano S, Hisaeda H, Himeno K.
- Journal Title
  
  Am J Trop Med Hyg 79
  
  Pages: 819-22
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590429
[Journal Article] Malaria parasites require TLR9 signaling for immune evasion by activating regulatory T cells2008
- Author(s)
  Hisaeda H, Tetsutani K, Imai T, Moriya C, Tu L, Hamano S, Duan X, Chou B, Ishida H, Aramaki A, Shen J, Ishii KJ, Coban C, Akira S, Takeda K, Yasutomo K, Torii M, Himeno K
- Journal Title
  
  J Immunol 180(4)
  
  Pages: 2496-503
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590429
[Journal Article] Concurrent Infection with Heligmosomoides polygyrus Modulates Murine Host Response against Plasmodium berghei ANKA Infection.2008
- Author(s)
  Tetsutani K., Ishiwata K., Torii M., Hamano S., Hisaeda H., Himeno K.
- Journal Title
  
  Am.J.Trop.Med.Hyg. 79
  
  Pages: 819-822
- Data Source
  KAKENHI-PROJECT-20406008
[Journal Article] Antigen-specific CD8^+ T cells induced by the ubiquitin fusion degradation pathway2008
- Author(s)
  Imai T, Duan X, Hisaeda H, Himeno K
- Journal Title
  
  Biochem Biophys Res Commun 365(4)
  
  Pages: 758-63
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590429
[Journal Article] Malaria parasites require TLR9 signaling for immune evasion by activating regulatory T cells2008
- Author(s)
  Hisaeda H, et. al.
- Journal Title
  
  The Journal of Immunology 180
  
  Pages: 2496-2503
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590400
[Journal Article] Malaria parasites require TLR9 signaling for immune evasion by activating regulatory T cells2008
- Author(s)
  Hisaeda H, et. al.
- Journal Title
  
  The Jourllal of Immunology 180
  
  Pages: 2496-2503
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590400
[Journal Article] Malaria parasites require TLR9 signaling for immune evasion by activating regulatory T cells.2008
- Author(s)
  Hisaeda H, Tetsutani K, Imai T, Moriya C, Tu L, Hamano S, Duan X, Chou B, Ishida H, Aramaki A, Shen J, Ishii KJ, Coban C, Akira S, Takeda K, Yasutomo K, Torii M, Himeno K
- Journal Title
  
  J Immunol 180
  
  Pages: 2496-2503
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390121
[Journal Article] Ubiquitin-fusion degradation pathway : a new strategy for inducing CD8 cells specific for mycobacterial HSP65.2008
- Author(s)
  Shen J, Hisaeda H, Chou B, Yu Q, Tu L, Himeno K.
- Journal Title
  
  Biochera Biophys Res Commun 10
  
  Pages: 241-50
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590429
[Journal Article] Critical contribution of immunoproteasomes in the induction of protective immunity against Trypanosoma cruzi in mice vaccinated with a plasmid encoding a CTL epitope fused to green fluorescence protein2008
- Author(s)
  Chou B, Hisaeda H, Shen J, Duan X, Imai T, Tu L, Murata S, Tanaka K, Himeno K
- Journal Title
  
  Microbes Infect 10(3)
  
  Pages: 241-50
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590429
[Journal Article] Ubiquitin-fusion degradation pathway : a new strategy for inducing CD8 cells specific for mycobacterial HSP652008
- Author(s)
  Shen J, Hisaeda H, Chou B, Yu Q, Tu L, Himeno K
- Journal Title
  
  Biochem Biophys Res Commun 365(4)
  
  Pages: 621-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590429
[Journal Article] Malaria parasites require TLR9 signaling for immune evasion by activating reeulatory T cells2008
- Author(s)
  Hisaeda H., et.al.
- Journal Title
  
  The Journal of Immunology 180
  
  Pages: 2496-2503
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19041056
[Journal Article] Malaria parasite induces tryptophan-related immune suppression inmice2007
- Author(s)
  Tetsutani K, To H, Torii M, Hisaeda H, Himeno K
- Journal Title
  
  Parasitology 134(Pt7)
  
  Pages: 923-30
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590429
[Journal Article] Immune therapy against tumors based on the ubiquitin-proteasome pathway2007
- Author(s)
  Himeno K, Hisaeda H
- Journal Title
  
  Fukuoka Igaku Zasshi(Review. Japanese) 98(8)
  
  Pages: 312-9
- NAID
  120000987727
- Data Source
  KAKENHI-PROJECT-19590429
[Journal Article] 寄生虫による免疫撹乱2006
- Author(s)
  久枝一
- Journal Title
  
  細胞工学 25・3
  
  Pages: 304-308
- Data Source
  KAKENHI-PROJECT-16017278
[Journal Article] Malaria : immune evasion by parasites (review)2005
- Author(s)
  Hajime Hisaeda et al.
- Journal Title
  
  The International Journal of Biochemistry & Cell Biology (印刷中)
- Data Source
  KAKENHI-PROJECT-16017278
[Journal Article] Resistance of regulatory T cells to glucocorticoid-induced TNFR family-related protein(GITR)signaling during Plasmodium yoelii infection2005
- Author(s)
  Hajime Hisaeda et al.
- Journal Title
  
  European Journal of Immunology 35
  
  Pages: 3516-3524
- Data Source
  KAKENHI-PROJECT-16017278
[Journal Article] Malaria : immune evasion by parasites.2005
- Author(s)
  Hisaeda H. et al.
- Journal Title
  
  Int J Biochem Cell Biol. 37・4
  
  Pages: 700-706
- Data Source
  KAKENHI-PROJECT-15390136
[Journal Article] Malaria : immune evasion by parasites.2005
- Author(s)
  Hisaeda H. et al.
- Journal Title
  
  Int.J.Biochem. Cell Biol. 37
  
  Pages: 700-706
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390136
[Journal Article] Resistance to GITR signaling in antigen specific CD4^+CD25^+ regulatory T cells during Plasmodium yoelii infection.2005
- Author(s)
  Hisaeda H. et al.
- Journal Title
  
  Eur.J.Immunol. 35
  
  Pages: 3516-3524
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390136
[Journal Article] Resistance to GITR signaling in antigen specific CD4^+CD25^+ regulatory T cells during Plasmodium yoelii infection.2005
- Author(s)
  Hisaeda H. et al.
- Journal Title
  
  Eur. J. Immunol. 35
  
  Pages: 3516-3524
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390136
[Journal Article] Malaria : immune evasion by parasites.2005
- Author(s)
  Hisaeda H. et al.
- Journal Title
  
  Int. J. Biochem. Cell Biol. 37
  
  Pages: 700-706
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390136
[Journal Article] Malaria : immune evasion by parasites.2005
- Author(s)
  Hisaeda H. et al.
- Journal Title
  
  Int.J.Biochem.Cell Biol. 37
  
  Pages: 700-706
- Data Source
  KAKENHI-PROJECT-15390136
[Journal Article] Malaria : immune evasion by parasites(review)2005
- Author(s)
  Hajime Hisaeda et al.
- Journal Title
  
  The International Journal of Biochemistry&Cell Biology 37
  
  Pages: 700-706
- Data Source
  KAKENHI-PROJECT-16017278
[Journal Article] Escape of malaria parasites from host immunity requires CD4^+CD25^+ regulatory T cells.2004
- Author(s)
  Hisaeda H. et al.
- Journal Title
  
  Nature Medicine 10(1)
  
  Pages: 29-30
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390136
[Journal Article] Escape of malaria parasites from host immunity requires CD4^+CD25^+regulatory T cells.2004
- Author(s)
  Hisaeda H. et al.
- Journal Title
  
  Nature Medicine 10・1
  
  Pages: 29-30
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390136
[Journal Article] ユビキチン-プロテアソームシステムの応用による癌遺伝子免疫2004
- Author(s)
  久枝一, 他
- Journal Title
  
  Annual Review免疫 (印刷中)
  
  Pages: 192-200
- Data Source
  KAKENHI-PROJECT-16017278
[Journal Article] Escape of malaria parasites from host immunity requires CD4^+CD25^+ regulatory T cells2004
- Author(s)
  Hajime Hisaeda et al.
- Journal Title
  
  Nature Medicine 10・1
  
  Pages: 29-30
- Data Source
  KAKENHI-PROJECT-16017278
[Journal Article] Malaria vaccines tha inhibit parasite spread by mosquito vectors.2003
- Author(s)
  Hisaeda H. et al.
- Journal Title
  
  Recent Research Developments in Immunology 5
  
  Pages: 34-38
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390136
[Journal Article] Malaria vaccines that inhibit parasite spread by mosquito vectors.2003
- Author(s)
  Hisaeda H. et al.
- Journal Title
  
  Recent Research Developments in Immunology 5
  
  Pages: 159-166
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390136
[Patent] 制御性Ｔ細胞増強剤並びにそれを含む医薬及び食品組成物2017
- Inventor(s)
  久枝一、下川周子、和泉孝志、大嶋紀安、大野博司、加藤完
- Industrial Property Rights Holder
  久枝一、下川周子、和泉孝志、大嶋紀安、大野博司、加藤完
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2017-094949
- Filing Date
  2017
- Data Source
  KAKENHI-PROJECT-15H05274
[Patent] 制御性T細胞増強剤並びにそれを含む医薬及び食品組成物2017
- Inventor(s)
  久枝一、下川周子、和泉孝志、大嶋紀安、大野博司、加藤完
- Industrial Property Rights Holder
  久枝一、下川周子、和泉孝志、大嶋紀安、大野博司、加藤完
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2017-094949
- Filing Date
  2017
- Data Source
  KAKENHI-PROJECT-15K08441
[Presentation] Transgenic Plasmodium cynomolgi reporter line expressing GFP-Luciferase to track liver-stage growth and dormancy2023
- Author(s)
  Araki T, Kawai S, Umeki Y, Kobayashi H, Tateishi Y, Saito-Nakano Y, Okamoto M, Yasutomi Y, Hisaeda H, Annoura T.
- Organizer
  BioMalPar XIX: biology and pathology of the malaria parasite
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07530
[Presentation] Anisakis-specific IgE production is associated with gastric bacteria2023
- Author(s)
  Shimokawa C, Hisaeda H.
- Organizer
  18th International Congress of Immunology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07530
[Presentation] Induction of Anisakis-specific IgE dependent on commensal bacteria in stomach during gastric Anisakis infection2023
- Author(s)
  Shimokawa C, Takeuchi T, Kato T, Sugiyama H, Ohno H, Hisaeda H
- Organizer
  Cytokines 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07530
[Presentation] Induction of Anisakis-specific IgE dependent on commensal bacteria in stomach during gastric Anisakis infection2023
- Author(s)
  Shimokawa C, Takeuchi T, Kato T, Sugiyama H, Ohno H, Hisaeda H
- Organizer
  第52回日本免疫学会
- Data Source
  KAKENHI-PROJECT-19K07530
[Presentation] 我が国における膣トリコモナスの感染実態2023
- Author(s)
  中野由美子, 梅木優子, 下川周子, 小林浩一, 橋本耕一, 髙田恭臣, 牧井千波, 長谷部里衣, 吉田友里, 中島理子, 小林正規, 久枝一
- Organizer
  第34回日本臨床寄生虫学会大会
- Data Source
  KAKENHI-PROJECT-19K07530
[Presentation] Prevention of drug-induced systemic sclerosis in mice infected with intestinal helminthes2019
- Author(s)
  Sekiguchi A, Motegi S, Ishikawa O, Shimokawa C, Hisaeda H.
- Organizer
  第４７回ヨーロッパ皮膚科研究学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07530
[Presentation] Trehalose from parasitic worm prevents type 1 diabetes by communicating with gut microbes2019
- Author(s)
  Shimokawa C, Kato T, Takeuchi T, Ohno H, Hisaeda H.
- Organizer
  Keystone symposia
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07530
[Presentation] 比較トランスクリプトームによるマラリア原虫受精因子の探索2012
- Author(s)
  平井誠、安彦真文、岡本龍司、本間一、鈴江一友、今井孝、堀井俊宏、田邉和裄、久枝一
- Organizer
  第１０回分子寄生虫・マラリアフォーラム、第７２回日本寄生虫学会東日本支部会合同大会
- Place of Presentation
  群馬大学医学部
- Year and Date
  2012-10-12
- Data Source
  KAKENHI-PUBLICLY-24117504
[Presentation] Training Course, Parasitology.2010
- Author(s)
  Hisaeda H
- Organizer
  第10回淡路国際感染症フォーラム
- Place of Presentation
  淡路国際会議場(兵庫県)
- Year and Date
  2010-09-08
- Data Source
  KAKENHI-PROJECT-20390121
[Presentation] Protection exerted by CD8^+ T cells against murine blood-stage malaria2010
- Author(s)
  Hisaeda H.
- Organizer
  The 14th International Conference of Immunology
- Place of Presentation
  神戸国際会議場
- Year and Date
  2010-08-21
- Data Source
  KAKENHI-PROJECT-20390121
[Presentation] Protective roles of IL-23 against murine malaria2010
- Author(s)
  Ishida H., Hisaeda H.
- Organizer
  The International Symposium of Inflammation
- Place of Presentation
  リスボンヒルトンホテル(ポルトガル)
- Year and Date
  2010-09-28
- Data Source
  KAKENHI-PROJECT-20390121
[Presentation] Protection exerted by CD8+ T cell sagainst murine blood-stage malaria.2010
- Author(s)
  Hisaeda H
- Organizer
  第14回国際免疫学会
- Place of Presentation
  神戸国際会議場(兵庫県)
- Year and Date
  2010-08-21
- Data Source
  KAKENHI-PROJECT-20390121
[Presentation] Protective roles of IL-23 against murine malaria.2010
- Author(s)
  Ishida H, Hisaeda H
- Organizer
  Cell炎症の国際シンポジウム
- Place of Presentation
  ヒルトンホテル(リスボン、ポルトガル)
- Year and Date
  2010-09-28
- Data Source
  KAKENHI-PROJECT-20390121
[Presentation] Protection exerted by CD8^+ T cells against murine blood-stage malaria2010
- Author(s)
  Hisaeda H.
- Organizer
  The 14th International Conference of Immunology
- Place of Presentation
  神戸国際会議場
- Year and Date
  2010-08-21
- Data Source
  KAKENHI-PUBLICLY-21022036
[Presentation] Influence of nematode infection of anti-malaria immunity in mice2010
- Author(s)
  Hajime Hisaeda
- Organizer
  Adaptive and Innate Immune Responses to Neglected Tropical Diseases Conference
- Place of Presentation
  Hilton San Diego Airport Hotel(San Diego, CA)
- Year and Date
  2010-01-11
- Data Source
  KAKENHI-PROJECT-20390121
[Presentation] Influence of nematode infection on anti-malaria immunity in mice.2010
- Author(s)
  Tetsutani K, Hisaeda H
- Organizer
  第44回日米医学協力プログラム
- Place of Presentation
  ヒルトンホテル(サンディエゴ、合衆国)
- Year and Date
  2010-01-10
- Data Source
  KAKENHI-PROJECT-20390121
[Presentation] MicroRNA-Ago2 Complex in Mature Human Red Blood Cell2010
- Author(s)
  Tsukuru Umemura, Yuka Tanak, Megumi Fujisaki, Shizuka Masaki, Hiromichi Shiotstu, Kanitta Srinoun, Suthat Fucharoen, Yasunobu Abe, Hisako Ichihara, Hiroyuki Toh, Hajime Hisaeda
- Organizer
  The 3rd International Conference on Thalas semia in China, "Advancing Knowledge in Thalassemia and Iron Disorders"
- Place of Presentation
  Nanning, Guangxi, P.R.China
- Data Source
  KAKENHI-PROJECT-21659240
[Presentation] Influence of nematode infection of anti-malaria immunity in mice2010
- Author(s)
  Hajime Hisaeda
- Organizer
  Adaptive and Innate Immune Responses to Neglected Tropical Diseases Conference
- Place of Presentation
  Hilton San Diego Airport Hotel(San Diego, CA)
- Year and Date
  2010-01-11
- Data Source
  KAKENHI-PUBLICLY-21022036
[Presentation] Protective roles of IL-23 against murine malaria2010
- Author(s)
  Ishida H., Hisaeda H.
- Organizer
  The International Symposium of Inflammation
- Place of Presentation
  リスボンヒルトンホテル(ポルトガル)
- Year and Date
  2010-09-28
- Data Source
  KAKENHI-PUBLICLY-21022036
[Presentation] MicroRNA-Ago2 Complex in Mature Human Red Blood Cells2009
- Author(s)
  T.Umemura, Y.Tanakal, M.Fujisaki, S.Masaki, H.Shiotsul, K.Srinoun, S.Fucharoen, Y.Abe, H.Ichihara, H.Toh, H.Hisaeda
- Organizer
  第51回米国血液学会
- Place of Presentation
  米国ルイジアナ州、ニューオリンズ
- Data Source
  KAKENHI-PROJECT-21659240
[Presentation] Malaria parasites require Toll-like receptor 9 signaling for immune evasion by acrivating regulatory Tcells.2008
- Author(s)
  Hisaeda H
- Organizer
  キーストーンシンポジウム
- Place of Presentation
  Alpbach Congress Centrum (Alpbach, Austria)
- Year and Date
  2008-06-10
- Data Source
  KAKENHI-PROJECT-20390121
[Presentation] マラリア原虫によるToll-likereceptor 9 を介した制御性T 細胞の活性化2007
- Author(s)
  久枝一
- Organizer
  第76回日本寄生虫学会大会
- Place of Presentation
  大阪大学
- Year and Date
  2007-03-29
- Data Source
  KAKENHI-PROJECT-19590429
[Presentation] Activation of regulatory T cells by dendritic cells in mice infected with malaria parasites2007
- Author(s)
  Hisaeda Hajime
- Organizer
  第37回日本免疫学会総会
- Place of Presentation
  グランドプリンスホテル新高輪、東京
- Year and Date
  2007-11-20
- Data Source
  KAKENHI-PROJECT-19590429
[Presentation] ネズミマラリアにおける腸管病変と腸内細菌叢の変化
- Author(s)
  谷口委代、久枝　一、他８名
- Organizer
  第８４回日本寄生虫学会
- Place of Presentation
  杏林大学医学部（東京都三鷹市）
- Year and Date
  2015-03-21 – 2015-03-22
- Data Source
  KAKENHI-PROJECT-25670226

1. HIMENO Kunisuke (50112339)

# of Collaborated Projects: 13 results

# of Collaborated Products: 12 results
2. SAKAI Tohru (40274196)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
3. HAMANO Shinjiro (70294915)

# of Collaborated Projects: 5 results

# of Collaborated Products: 12 results
4. 長澤秀行 (60172524)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. HIGO Hiroo (80117225)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 勝沼信彦 (50035375)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 堀井俊宏 (80142305)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 足立昭夫 (90127043)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 藤井潤 (60271441)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 青木洋介 (60222478)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 楠原浩一 (20243941)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 持田信治 (40412374)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 野崎智義 (60198588)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 梅村創 (90136432)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
15. 藤博幸 (70192656)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
16. 市原寿子 (50362398)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
17. KUMAR Nirbhay

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. AIKAWA Masamichi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. POLLA Barbara S.

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. Imai Takashi

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
21. Ohno Hiroshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. Miyauchi Eiji

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. Emmanuel Odongo-Aginya

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. Olia Alex

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. Ogwang Martin

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. S.POLLA Barb

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 平井誠

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results

Hisaeda Hajime 久枝 一

HISAEDA Hajime 久枝 一

Research Projects

Research Products

Co-Researchers

Identification of host pathogenic factors responsible for development of cerebral malariaPrincipal Investigator

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Host-parasite interaction in eythroblastic infection during malariaPrincipal Investigator

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Analyses of interaction between malaria and intestinal microbiota in patients in UgandaPrincipal Investigator

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Effects of intestinal microbita on immune modulation during helminthic infections and its application to prevention of inflammatory disordersPrincipal Investigator

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次世代オルガネラ学の革新的ツールである超高速進化型マラリア原虫の創成Principal Investigator

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マラリアにおける免疫回避に関わる宿主寄生体相互作用の解析Principal Investigator

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Review Section

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Molecular basis of immune evasion of malaria parasitesPrincipal Investigator

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マラリア原虫の病原性を決定する免疫抑制メカニズムの解明Principal Investigator

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Principal Investigator

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Analyses for immune evasion by malaria parasitesPrincipal Investigator

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Principal Investigator

Hisaeda Hajime 久枝一

HISAEDA Hajime 久枝一