TAKIKAWA Yasuhiro 滝川康裕

Researcher Number	50254751
Other IDs
External Links
Affiliation (Current)	2023: 岩手医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2013 – 2021: 岩手医科大学, 医学部, 教授 2014: 岩手医科大学医学部, 消化器・肝臓内科肝臓分野, 教授 2010 – 2011: 岩手医科大学, 医学部, 教授 2007 – 2009: Iwate Medical University, 医学部, 准教授 2005 – 2006: 岩手医科大学, 医学部, 助教授 2002 – 2003: 岩手医科大学, 医学部, 講師 1996 – 1999: 岩手医科大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Gastroenterology / Gastroenterology / Basic Section 53010:Gastroenterology-related Except Principal Investigator Gastroenterology / Gastroenterology / Basic Section 53010:Gastroenterology-related
Keywords	Principal Investigator 肝再生 / 肝前駆細胞 / 急性肝不全 / 劇症肝炎 / アポトーシス / 偽胆管 / Bcl-xL / 肝細胞 / 肝再生不全 / サイトカイン … More / 細胆管反応 / 肝幹 / 前駆細胞 / シグナル伝達 / 肝細胞再生 / JNK / 生物学的人工肝臓 / AFP / アルファフェトプロテイン / 増殖環境 / 肝細胞アポトーシス / フォスファチジルセリン / 血液凝固 / 広汎肝細胞死 / プロスタグランディン / Hepatocyte apoptosis / Phosphatidyl serine / Blood coagulation / Massive hepatocyte death / Pros tagland in / IL-8 / 胆管細胞 / 血管内皮細胞増殖因子 / 類洞内皮 … More Except Principal Investigator アポトーシス / インターフェロン / 肝硬変 / 肝性脳症 / 時計遺伝子 / 日内変動 / マウス肝細胞 / ウイルス / 薬剤反応 / 細胞・組織 / シグナル伝達 / 肝炎ウイルス / 薬物反応 / 細胞・祖時期 / カルノシン酸 / シグナル / 酸化ストレス / 細胞死 / Carnosic acid / Nrf2 / Oxidative stress / 潜在性肝性脳症 / 肝性脳症診断用コンピュータシステム / ポジトロン断層法 / 脳内糖代謝 / 磁気共鳴画像(MRI) / 磁気共鳴分析法(MRS) / 淡蒼球信号強度 / glutamine, myoinositol / 脳内ブトウ糖代謝量 / glutamine,myoinositol / 定量的神経機能検査 / BZ受容体 / 日内行動リズム / subclinical hepatic encephalopathy / computer-assisted quantitative neuropsychological tests / positron emission tomography / cerebral glucose metabolism / magnetic resonance imaging / magnetic resonance spectroscopy / pallidal high intensity / glutamine and myoinositol / 急性肝不全 / 劇症肝炎 / 肝細胞壊死 / Fasリガンド / TNF受容体 / 副腎皮質ステロイド薬 / 免疫抑制薬 / ネクローシス / サイトカイン / acute liver failure / Fulminant hepatitis / liver necrosis / anootosis / Fas ligand / TNF receptor / glucocoryicoid / immunosuppressive drug / TGF-β / IFN/5-FU 併用療法 / HCC / IFNα-2b / 5-FU / ERK1/2 / E-cadherin / Claudin-1 / 浸潤性肝癌 / 化学併用療法 / TGFβ / カスパーゼ非依存性細胞死 / フルクトース / 不飽和脂肪酸 / 活性酸素種 / MLKLリン酸化 / Hemoxygenase-1 / リゾリン脂質アシル基転移酵素 / 非アルコール性脂肪肝炎 / 非アルコール性脂肪肝 / 非アルコール性脂肪性肝疾患 / 非アポトーシス細胞死 Less

Investigation of an optimal environment for the proliferation of mature hepatocytes toward the rescue of acute liver failure patientsPrincipal Investigator
- Principal Investigator
  
  Takikawa Yasuhiro
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Iwate Medical University
Regulation of non-apoptotic cell death to treat non-alcoholic steatohepatitis
- Principal Investigator
  
  Kakisaka Keisuke
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Iwate Medical University
The study for the proliferation mechanism of functional hepatocyte to address the impaired liver regeneration syndromePrincipal Investigator
- Principal Investigator
  
  Takikawa Yasuhiro
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Iwate Medical University
Regulation of transforming growth factor is involved in the efficacy of combined 5-fluorouracil and interferon alpha-2b therapy of advanced hepatocellular carcinoma
- Principal Investigator
  
  WANG TING
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Iwate Medical University
Study on the proliferation mechanism of mature and progenitor hepatocytes for the treatment of impaired regeneration of the liverPrincipal Investigator
- Principal Investigator
  
  Takikawa Yasuhiro
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Iwate Medical University
Clarifying the molecular mechanism of the Nrf-2 activator carnosic acid in the regulation of the hepatocyte apoptosis
- Principal Investigator
  
  WANG TING
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Iwate Medical University
Influence of interferon on the functional and structural changes of central nervous system from the viewpoints of aging and gender
- Principal Investigator
  
  SUZUKI Kazuyuki
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Iwate Medical University
Identification and characterization of hepatocyte regenerativefactor in the plasma of patients with fulminant hepatitisPrincipal Investigator
- Principal Investigator
  
  TAKIKAWA Yasuhiro
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Iwate Medical University
肝性脳症における時計遺伝子の発現動態に関する検討
- Principal Investigator
  
  SUZUKI Kazuyuki
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Gastroenterology
- Research Institution
  Iwate Medical University
Study for implication of apoptotic mechanism in massive hepatic cell death and its controlPrincipal Investigator
- Principal Investigator
  
  TAKIKAWA Yasuhiro
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Iwate Medical University
Clinical and experimental study for regulation of apoptosis and necrosis in acute liver failure
- Principal Investigator
  
  SUZUKI Kazuyuki
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Iwate Medical University
Reassessment of the pathogenesis and the management of hepatic encephalopathy : include the cases of subclinical hepatic encephalopathy
- Principal Investigator
  
  SATO Shunichi
- Project Period (FY)
  1996 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Iwate Medical University

[Book] Muse cells: A New Era of Pluripotent Stem Cells2018
- Author(s)
  Nishizuka S, Katagiri K, Suzuki Y, and Takikawa Y.
- Total Pages
  22
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-16K09370
[Book] Muse cells: A New Era of Pluripotent Stem Cells2016
- Author(s)
  Nishizuka SS, Katagiri H, Suzuki Y, Takikawa Y.
- Total Pages
  12
- Publisher
  Ｓｐｒｉｎｇｅｒ
- Data Source
  KAKENHI-PROJECT-25461008
[Journal Article] 肝障害時における胆管増生と血管新生の3次元的構造解析2022
- Author(s)
  阿部弘昭, 鈴木悠地, 村嶋亜紀，柿坂啓介, 宮坂昭生, 佐々木登希夫, 木村英二,人見次郎, 滝川康裕
- Journal Title
  
  岩手医学雑誌
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08475
[Journal Article] Referral system has a diminished difference in the risk for hepatic encephalopathy development among each etiology in patients with acute liver injury.2022
- Author(s)
  Kakisaka K, Suzuki Y, Takahashi F, Takikawa Y.
- Journal Title
  
  Hepatol Res
  
  Volume: 52 Pages: 401-410
- DOI
  10.1111/hepr.13744
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08475
[Journal Article] Tc-99m GSA scintigraphy within the first 3 days after admission as an early predictor of outcome in severe acute liver injury.2021
- Author(s)
  Suzuki Y, Kakisaka K, Sato T, Mikami R, Abe H, Sasaki T, Takikawa Y.
- Journal Title
  
  Sci Rep
  
  Volume: 11 Pages: 12518-12518
- DOI
  10.1038/s41598-021-92058-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08475
[Journal Article] Contrast‐Enhanced Ultrasonography?Based Hepatic Perfusion for Early Prediction of Prognosis in Acute Liver Failure2021
- Author(s)
  Kuroda H, Abe T, Fujiwara Y, Nagasawa T, Suzuki Y, Kakisaka K, Takikawa Y.
- Journal Title
  
  Hepatology
  
  Volume: 5 Pages: 2455-2465
- DOI
  10.1002/hep.31615
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08400, KAKENHI-PROJECT-19K08475
[Journal Article] Serum alpha- fetoprotein increases prior to fibrosis resolution in a patient with acute liver failure.2021
- Author(s)
  Kakisaka K, Suzuki Y, Abe H, Eto H, Kanazawa J, Takikawa Y
- Journal Title
  
  Clin J Gastroenterol
  
  Volume: 14 Pages: 1470-1475
- DOI
  10.1007/s12328-021-01467-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08475
[Journal Article] Multicenter study on the consciousness‐regaining effect of a newly developed artificial liver support system in acute liver failure: An on‐line continuous hemodiafiltration system2020
- Author(s)
  Takikawa Yasuhiro、Kakisaka Keisuke、Suzuki Yuji、Ido Akio、Shimamura Tsuyoshi、Nishida Osamu、Oda Shigeto、Shimosegawa Tooru
- Journal Title
  
  Hepatology Research
  
  Volume: 51 Pages: 216-226
- DOI
  10.1111/hepr.13557
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08475
[Journal Article] Early identification using the referral system prolonged the time to onset for hepatic encephalopathy after diagnosing severe acute liver injury2020
- Author(s)
  Kakisaka Keisuke、Suzuki Yuji、Abe Hiroaki、Watanabe Takuya、Yusa Kenji、Sato Hiroki、Takikawa Yasuhiro
- Journal Title
  
  Scientific Reports
  
  Volume: 10
- DOI
  10.1038/s41598-020-74466-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08475
[Journal Article] Unfavorable prognosis of patients with acute liver injury due to drug-induced liver injury and acute exacerbation of hepatitis B virus infection.2019
- Author(s)
  Kakisaka K, Suzuki Y, Jinnouchi Y, Kanazawa J, Sasaki T, Yonezawa T, Yoshida Y, Kuroda H, Takikawa Y.
- Journal Title
  
  Hepatol Res.
  
  Volume: 49 Pages: 1286-1293
- DOI
  10.1111/hepr.13397
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08475
[Journal Article] IL-8 induces transdifferentiation of mature hepatocytes toward the cholangiocyte phenotype.2019
- Author(s)
  Sasaki T, Suzuki Y, Kakisaka K, Wang T, Ishida K, Suzuki A, Abe H, Sugai T, Takikawa Y
- Journal Title
  
  FEBS Open Bio.
  
  Volume: 0 Pages: 0-0
- DOI
  10.1002/2211-5463.12750
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07737, KAKENHI-PROJECT-19K08475, KAKENHI-PROJECT-17K08700, KAKENHI-PROJECT-18K15825
[Journal Article] L-carnitine prevents ammonia-induced cytotoxicity and disturbances in intracellular amino acid levels in human astrocytes.2019
- Author(s)
  Wang Ting、Suzuki Kazuyuki、Kakisaka Keisuke、Onodera Mio、Sawara Kei、Takikawa Yasuhiro
- Journal Title
  
  J Gastroenterol Hepatol.
  
  Volume: - Pages: 1249-1255
- DOI
  10.1111/jgh.14497
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K19346, KAKENHI-PROJECT-19K08475
[Journal Article] Regulation of transforming　growth factor is involved in the efficacy of combined 5-fluorouracil and　interferon alpha-2b therapy of advanced hepatocellular carcinoma2018
- Author(s)
  Okada Y, Wang T, Kasai K, Suzuki K, Takikawa Y.
- Journal Title
  
  Cell Death　Discov.
  
  Volume: 12 Pages: 40-42
- DOI
  10.1038/s41420-018-0040-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09020
[Journal Article] Liver Regeneration Supported by Muse Cells2018
- Author(s)
  Nishizuka SS, Suzuki Y, Katagiri H, Takikawa Y.
- Journal Title
  
  Adv Exp Med Biol.
  
  Volume: 1103 Pages: 219-241
- DOI
  10.1007/978-4-431-56847-6_12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09370, KAKENHI-PROJECT-15KK0317
[Journal Article] Caspase-independent hepatocyte death: A result of the decrease of lysophosphatidylcholine acyltransferase 3 in non-alcoholic steatohepatitis.2018
- Author(s)
  Kakisaka K, Suzuki Y, Fujiwara Y, Suzuki A, Kanazawa J, Takikawa Y
- Journal Title
  
  J Gastroenterol Hepatol.
  
  Volume: Epub ahead on print
- DOI
  10.1111/jgh.14461
- NAID
  120006576879
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07980
[Journal Article] Serum markers for mitochondrial dysfunction and cell death are possible predictive indicators for drug-induced liver injury by direct acting antivirals.2018
- Author(s)
  Kakisaka K, Yoshida Y, Suzuki Y, Sato T, Kuroda H, Miyasaka A, Takikawa Y
- Journal Title
  
  Hepatol Res
  
  Volume: 48 Pages: 78-86
- NAID
  120006313048
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09370
[Journal Article] A predictive formula of coma onset and prothrombin time to distinguish patients who recover from acute liver injury.2018
- Author(s)
  Kakisaka K, Suzuki Y, Kataoka K, Okada Y, Miyamoto Y, Kuroda H, Takikawa Y.
- Journal Title
  
  J Gastroenterol Hepatol
  
  Volume: 52 Pages: 277-282
- NAID
  120006313049
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09370
[Journal Article] Appropriate timing to start and optimal response evaluation of high-dose corticosteroid therapy for patients with acute liver failure2017
- Author(s)
  Kakisaka K, Kataoka K, Suzuki, Y, Kuroda H, Takikawa Y.
- Journal Title
  
  J Gastroenterol
  
  Volume: 52 Pages: 977-985
- NAID
  120006313047
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09370
[Journal Article] Appropriate timing to start and optimal response evaluation of high-dose corticosteroid therapy for patients with acute liver failure.2017
- Author(s)
  82.Kakisaka K, Kataoka K, Suzuki, Y, Kuroda H, Takikawa Y.
- Journal Title
  
  Hepatol Res
  
  Volume: -
- NAID
  120006313047
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16K09370
[Journal Article] Carnosic acid protects normal mouse hepatocytes against H2O2 -induced cytotoxicity via sirtuin 1-mediated signaling.2016
- Author(s)
  Wang T, Takikawa Y.
- Journal Title
  
  Hepatol Res.
  
  Volume: 46 Pages: 239-46
- DOI
  10.1111/hepr.12563
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09020
[Journal Article] c-Jun N-terminal kinase-mediated Rubicon expression enhances hepatocyte lipoapoptosis and promotes hepatocyte ballooning.2016
- Author(s)
  Suzuki A, Kakisaka K, Suzuki Y, Wang T, Takikawa Y.
- Journal Title
  
  World journal of Gastroenterology
  
  Volume: 22 Pages: 6509-19
- DOI
  10.3748/wjg.v22.i28.6509
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09020, KAKENHI-PROJECT-16K21307
[Journal Article] Ductular reactions in the liver regeneration process with local inflammation after physical partial hepatectomy.2016
- Author(s)
  Suzuki Y, Katagiri H, Wang T, Kakisaka K, Kume K, Nishizuka SS, Takikawa Y.
- Journal Title
  
  Lab Invest
  
  Volume: 96 Pages: 1211-1222
- DOI
  10.1038/labinvest.2016.97
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09020, KAKENHI-PROJECT-16K09370
[Journal Article] Muse細胞による肝切除後細胞補塡療法の可能性2016
- Author(s)
  西塚哲，鈴木悠地，滝川康裕
- Journal Title
  
  Organ Biology
  
  Volume: 23 Pages: 999-999
- Data Source
  KAKENHI-PROJECT-25461008
[Journal Article] Bimodal peaks of liver stiffness in a case of drug-induced liver injury2015
- Author(s)
  Kakisaka K, Kooka Y, Oikawa T, Suzuki A, Oikawa K, Kuroda H, Kasai K,
- Journal Title
  
  Hepatol Res
  
  Volume: 45 Pages: 343-348
- DOI
  10.1111/hepr.12341
- NAID
  120005867727
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08353, KAKENHI-PROJECT-25461008
[Journal Article] Alpha-fetoprotein: A biomarker for the recruitment of progenitor cells in the liver in patients with acute liver injury or failure2015
- Author(s)
  Kakisaka K, Kataoka K, Onodera M, Suzuki A, Endo K, Tatemichi Y, Kuroda H, Ishida K, Takikawa Y
- Journal Title
  
  Hepatol Res
  
  Volume: 45 Pages: 12-20
- DOI
  10.1111/hepr.12448
- NAID
  120005867728
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460463, KAKENHI-PROJECT-25461008
[Journal Article] Clinical significance of Virtual touch quantification in acute hepatitis2015
- Author(s)
  黒田英克，滝川康裕，柿坂啓介
- Journal Title
  
  Choonpa Igaku
  
  Volume: 42 Issue: 4 Pages: 505-516
- DOI
  10.3179/jjmu.jjmu.r.38
  10.3179/jjmu.JJMU.R.38
- NAID
  130004696058
- ISSN
  1346-1176, 1881-9311
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461008
[Journal Article] Proliferation of mouse liver stem/progenitor cells induced by plasma from patients with acute liver failure is modulated by P2Y receptor-mediated JNK activation.2015
- Author(s)
  Wang T, Takikawa Y, Watanabe A, Kakisaka K, Oigawa K, Miyamoto Y, Suzuki K.
- Journal Title
  
  J Gastroenterol
  
  Volume: 49 Pages: 1557-1566
- DOI
  10.1007/s00535-013-0927-6
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24590992, KAKENHI-PROJECT-25461008, KAKENHI-PROJECT-25461009
[Journal Article] Liver stiffness measured by acoustic radiation force impulse elastography reflects the severity of liver damage and prognosis in patients with acute liver failure2015
- Author(s)
  Kuroda H, Takikawa Y, Kakisaka K.
- Journal Title
  
  Hepatol Res
  
  Volume: 45 Pages: 571-577
- DOI
  10.1111/hepr.12389
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461008
[Journal Article] The usefulness and accuracy of international normalized ratio (INR) and activity percent of prothrombin time in patients with liver disease.2014
- Author(s)
  Takikawa Y, Harada M, Wang T, Suzuki K.
- Journal Title
  
  Hepatology Research
  
  Volume: 44 Pages: 92-101
- DOI
  10.1111/hepr.12093
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24590992, KAKENHI-PROJECT-25461008, KAKENHI-PROJECT-25461009
[Journal Article] Proliferation of mouse liver stem/progenitor cells induced by plasma from patients with acute liver failure is modulated by P2Y2 receptor-mediated JNK activation.2013
- Author(s)
  Wang T, Takikawa Y, Watanabe A, Kakisaka K, Oikawa K, Miyamoto Y, Suzuki K.
- Journal Title
  
  J Gastroenterol.
  
  Volume: Epub ahead of print
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590992
[Journal Article] FGF7 is a functional niche signal required for stimulation of adult liver progenitor cells that support liver regeneration2013
- Author(s)
  Takase HM, Itoh T, Ino S, Wang T, Koji T, Akira S, Takikawa Y, Miyajima A.
- Journal Title
  
  Genes Development
  
  Volume: 27 Pages: 169-181
- DOI
  10.1101/gad.204776.112
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590342, KAKENHI-PROJECT-25461008, KAKENHI-PLANNED-22118006, KAKENHI-PUBLICLY-24112507
[Journal Article] Negative regulation of human astrocytes by IFNα: the involvement of growth inhibition and impaired glucose utilization2012
- Author(s)
  Wang T, Takikawa Y, Sawara K, Yoshida S, Suzuki K
- Journal Title
  
  Neurochem Res
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590857
[Journal Article] Negative regulation of human astrocytes by Interferon (IFN) α in relation to growth inhibition and impaired glucose utilization.2012
- Author(s)
  Wang T, TakikawaY, Sawara K, YoshidaY, Suzuki K.
- Journal Title
  
  Neurochem Res
  
  Volume: 37 Pages: 1898-905
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590992
[Journal Article] Carnosic acid prevents lipid accumulation in hepatocytes through EGF/MAPK pathway2012
- Author(s)
  Wang T, Takikawa Y, Tabuchi T, Kosaka K, Satoh T, Suzuki K. .
- Journal Title
  
  J Gastroenterol
  
  Volume: 47 Pages: 805-13
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590992
[Journal Article] Therapeutic efficacy of combination therapy with intra-arterial 5-fluorouracil and systemic pegylated interferon a-2b for advanced hepatocellular carcinoma with portal venous invasion2011
- Author(s)
  Kasai K, Ushio A, Kasai Y, Sawara K, Miyamoto Y, Oikawa K, Kuroda H, Takikawa Y, Suzuki K
- Journal Title
  
  Cancer
- DOI
  10.1002/cncr.26648
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590857
[Journal Article] Evaluation of newly developed combination therapy of intra-arterial 5-fluorouracil and systemic pegylated interferon alpha-2b for advanced hepatocellular carcinoma with portal venous invasion : preliminary results2009
- Author(s)
  Kasai K, Kuroda H, Ushio A, Sawara K, Takikawa Y, Suzuki K
- Journal Title
  
  Hepatol Res
  
  Volume: 39 Pages: 117-125
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590857
[Journal Article] Evaluation of newly developed combination therapy of intra-arterial 5-fluorouracil and systemic pegylated interferon alpha-2b for advanced hepatocellular carcinoma with portal venous invasion : preliminary results2009
- Author(s)
  Kasai K, Kuroda H, Ushio A, Sawara K, Takikawa Y, Suzuki K
- Journal Title
  
  Hepatol Res 39
  
  Pages: 117-125
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590857
[Journal Article] Differential microRNA expression between bone marrow side population cells and hepatocytes in adult mice.2009
- Author(s)
  Nagata Y, Maesawa C, Tada H, Takikawa Y, Yashima-Abo A, Masuda T.
- Journal Title
  
  Int J Mol Med In print
- Data Source
  KAKENHI-PROJECT-19590785
[Journal Article] The influence of plasma of acute liver failure patients on survival of a mouse stem/progenitor cell line2009
- Author(s)
  Kakisaka K. Takikawa Y. Onodera M. Wang T.
- Journal Title
  
  J Iwate Medical Assoc 57in print
- NAID
  110007349269
- Data Source
  KAKENHI-PROJECT-19590785
[Journal Article] Clinical impact of serum transforming growth factor-alpha mRNA as a predictive biomarker for the prognosis of fulminant hepatitis2008
- Author(s)
  Miura N, Takikawa Shiota G, 他11名
- Journal Title
  
  Hepatol Int 2
  
  Pages: 213-221
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590785
[Journal Article] Clinical epidemiology of fulminant hepatitis in Japan2008
- Author(s)
  Takikawa Y, Suzuki K.
- Journal Title
  
  Hepatol Res 38(Suppl.1)
- NAID
  10025323064
- Data Source
  KAKENHI-PROJECT-19590785
[Journal Article] Acute on chronic liver failure (ACLF) : Consensus recommendations of the asian pacific association for the study of the liver (APASL).2008
- Author(s)
  Shiv Kumar Sarin, Ashish Kumar, Yasuhiro Takikawa, 他20名
- Journal Title
  
  Hepatol Int 3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590785
[Journal Article] Acute on chronic liver failure(ACLF)Consensus recommendations of the asian pacific association for the study of the liver (APASL)2008
- Author(s)
  Shiv Kumar Sarin, Ashish Kumar, Yasuhiro Takikawa, 他22名
- Journal Title
  
  Hepatol Int (in print)
- Data Source
  KAKENHI-PROJECT-19590785
[Journal Article] Clinical epidemiology of fulminant hepatitis in Japan2008
- Author(s)
  Takikawa Y Suzuki K
- Journal Title
  
  Hepatol Res 38(Suppl. 1)
- NAID
  10025323064
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590785
[Journal Article] Interleukin-17 as new marker of severity of acute hepatic injury.2007
- Author(s)
  Yasumi Y, Takikawa Y, Endo R, Suzuki K..
- Journal Title
  
  Hepatology Research 37
  
  Pages: 258-264
- NAID
  10020164207
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590785
[Journal Article] Initial load of hepatitis B virus(HBV),its changing profile and precore/core promoter mutations correlate with the severity and outcome of acute HBV infection.2007
- Author(s)
  Sainokami S, Abe K, Sato A, Endo R, Takikawa Y, Suzuki K, Okamoto H.
- Journal Title
  
  J Gastroenterol 42
  
  Pages: 241-249
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590785
[Journal Article] Initial load of hepatitisB virus(HBV), its changing profile and precore/core promoter mutations correlate with the severity and outcome of acute HBV infection2007
- Author(s)
  Sainokami S, Abe K, Sato A, Endo R, Takikawa Y, Suzuki K, Okamoto H.
- Journal Title
  
  J Gastroenterol 42
  
  Pages: 241-249
- Data Source
  KAKENHI-PROJECT-19590785
[Journal Article] Interleukin-17 as new marker of severity of acute hepatic injury2007
- Author(s)
  Yasumi Y, Takikawa Y, Endo R, Suzuki K.
- Journal Title
  
  Hep Res 37
  
  Pages: 248-254
- NAID
  10020164207
- Data Source
  KAKENHI-PROJECT-19590785
[Presentation] 消化器領域の救急医療、急性肝不全　急性肝不全の予後不良となる病態解明の試み2021
- Author(s)
  柿坂啓介, 鈴木悠地, 滝川康裕
- Organizer
  第107回日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-19K08475
[Presentation] 肝移植の現状と課題　重症アルコール性肝炎に対する早期生体肝移植の適応と倫理的評価2021
- Author(s)
  鈴木悠地, 柿坂啓介, 滝川康裕
- Organizer
  第57回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-19K08475
[Presentation] 肝移植の現状と課題　肝移植医療における急性肝障害患者の施設間共同管理の効果2021
- Author(s)
  柿坂啓介, 鈴木悠地, 滝川康裕
- Organizer
  第57回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-19K08475
[Presentation] 病診連携による急性肝不全の内科治療向上の試みと今後の展望2019
- Author(s)
  柿坂啓介、鈴木悠地、滝川康裕．
- Organizer
  第55回日本腹部救急医学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-19K08475
[Presentation] 昏睡型急性肝不全に対するOn-line CHDFの昏睡覚醒効果に関する前向き国内多施設共同研究結果報告2019
- Author(s)
  鈴木悠地、柿坂啓介、滝川康裕．
- Organizer
  第55回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-19K08475
[Presentation] IL-8は成熟肝細胞において胆管上皮細胞の表現型を誘導する．2019
- Author(s)
  佐々木登希夫，鈴木悠地，王挺，柿坂啓介，滝川康裕．
- Organizer
  第45回日本急性肝不全研究会
- Data Source
  KAKENHI-PROJECT-19K08475
[Presentation] 急性肝障害の予後不良要因としての薬物性肝障害の特徴2019
- Author(s)
  柿坂啓介、鈴木悠地、滝川康裕．
- Organizer
  第23回肝臓学会大会
- Data Source
  KAKENHI-PROJECT-19K08475
[Presentation] IL-8 induces transdifferentiation of mature hepatocytes toward the cholangiocyte phenotype.2018
- Author(s)
  Sasaki T, Suzuki Y, Kakisaka K, Wang T, Takikawa Y.
- Organizer
  International Society for Stem Cell Research Annual Meeting 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09370
[Presentation] Technetium-99m-GSA Scintigraphy Obtained Within Three Days of Admission as an Early Predictor of Outcome in Acute Liver Failure and Severe Acute Hepatitis.2017
- Author(s)
  Suzuki Y, Kakisaka K, Sato T, Mikami R, Takikawa Y.
- Organizer
  The 68th Annual Meeting of the American Association for the Study of Liver Disease (AASLD)
- Data Source
  KAKENHI-PROJECT-16K09370
[Presentation] 急性肝障害における薬物性肝障害の重症度評価の問題について2017
- Author(s)
  柿坂啓介, 宮本康弘, 滝川康裕
- Organizer
  第53回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-16K09370
[Presentation] Anti-tumor effect of Carnosic acid on human hepatoma cell lines2017
- Author(s)
  wang T, Takikawa Y.
- Organizer
  The APASL Single Topic Conference in Nagasaki
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09020
[Presentation] The effects of 5-fluorouracil (5-FU) on TGF-β-related signaling molecules2017
- Author(s)
  Wang T, Takikawa Y.
- Organizer
  European Society for Medical Oncology　（ＥＳＭＯ）　２０１７　Ｃｏｎｇｒｅｓｓ
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09020
[Presentation] 急性肝不全の予後予測における画像診断の意義：肝硬度と肝容積の比較検討2016
- Author(s)
  黒田英克、柿坂啓介、滝川康裕
- Organizer
  第52回日本肝臓学会総会　パネルディスカッション
- Place of Presentation
  幕張
- Year and Date
  2016-05-20
- Data Source
  KAKENHI-PROJECT-25461008
[Presentation] 急性肝不全の予後予測におけるエラストグラフィーの有用性- 肝硬度と肝萎縮の関係2016
- Author(s)
  黒田英克、柿坂啓介、滝川康裕
- Organizer
  日本超音波医学会第89回学術集会消化器　パネルディスカッション
- Place of Presentation
  神戸
- Year and Date
  2016-05-27
- Data Source
  KAKENHI-PROJECT-25461008
[Presentation] 5.Liver Stem/progenitor cells in the mouse liver regeneration process with local inflammation after a physical partial hepatectomy.2016
- Author(s)
  Suzuki Y, Kakisaka K, Nishizuka SS，Takikawa Y.
- Organizer
  International society for stem cell research
- Place of Presentation
  San Francisco, USA
- Year and Date
  2016-06-22
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461008
[Presentation] 急性肝不全症例における薬物性肝障害の病態解明の試み2015
- Author(s)
  柿坂啓介，滝川康裕
- Organizer
  第101回日本消化器病学会総会
- Place of Presentation
  仙台
- Year and Date
  2015-04-22
- Data Source
  KAKENHI-PROJECT-25461008
[Presentation] 急性肝不全におけるVTQの臨床的有用性 -肝硬度と血行動態に関する検討2015
- Author(s)
  黒田英克，滝川康裕
- Organizer
  日本超音波医学会第88回学術集会ワークショップ
- Place of Presentation
  東京
- Year and Date
  2015-05-22
- Data Source
  KAKENHI-PROJECT-25461008
[Presentation] 急性肝障害・急性肝不全における血清AFPの意義：生体肝移植ドナーとの比較2014
- Author(s)
  柿坂啓介，片岡晃二郎，小野寺美緒，舘道芳徳，及川寛太，滝川康裕
- Organizer
  第100回日本消化器病学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-25461008
[Presentation] IFN-α/5-FU併用によるTGFβシグナルへの影響2013
- Author(s)
  王挺、滝川康裕、葛西和博、渡辺亜沙子、鈴木一幸。
- Organizer
  第49回肝臓学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24590992
[Presentation] Carnosic acid protects against oxidative stress-induced cytotoxicity in primary hepatocytes, induces tumor cell death, and inhibits TGFβ-induced migration and invasion in HepG2 cells.2013
- Author(s)
  Takikawa Y、Wang T, Watanabe A, Kakisaka K, Onodera M, Oikawa K.
- Organizer
  AASLD
- Place of Presentation
  Washington DC.
- Data Source
  KAKENHI-PROJECT-24590992
[Presentation] Interferon-α inhibits the proliferation of human astrocyte and decrease the expression glucose transporter Glut-12011
- Author(s)
  Wang T, Takikawa Y, Yoshida S, Sawara K, Suzuki K
- Organizer
  22^<st> APDW
- Place of Presentation
  Singapore, Malaysia
- Year and Date
  2011-10-07
- Data Source
  KAKENHI-PROJECT-21590857
[Presentation] Interferon-α inhibits the proliferation of human astrocyte and decrease the expression of glucose transporter Glut-12011
- Author(s)
  Takikawa Y, Suzuki K, et al.(5名中5番目)
- Organizer
  Asia Pacific Digestive Weeks (APDW)
- Place of Presentation
  Singapore
- Year and Date
  2011-10-02
- Data Source
  KAKENHI-PROJECT-21590857
[Presentation] Cerebral glucose metabolism and neuropsychiatric symptoms in chronic hepatitis C patients under antiviral therapy2011
- Author(s)
  Sawara K, Yoshida S, Oikawa A, Miyasaka A, Endo R, Takikawa Y, Kato A, Suzuki K
- Organizer
  21^<st> APASL
- Place of Presentation
  Bangkok, Thailand
- Year and Date
  2011-02-17
- Data Source
  KAKENHI-PROJECT-21590857
[Presentation] Fulminant hepatic failure plasma suppresses cell proliferation and activates JNK phosphorylation in mouse liver stem/progenitor cells.2008
- Author(s)
  Kakisaka K, Takikawa Y, Inoue E, Onodera M, Lin SD, Suzuki K
- Organizer
  AASLD
- Place of Presentation
  San Francisco, USA
- Year and Date
  2008-11-01
- Data Source
  KAKENHI-PROJECT-19590785
[Presentation] A comprehensive analysis of csurvival and the proliferation signals in hepatocyte : effects of growth factors, Fas ligand, bile acids and fulminant hepatic failure plasma2008
- Author(s)
  Kakisaka K, Takikawa Y, Inoue E, Onodera M, Lin SD, Suzuki K.
- Organizer
  APASL Seoul
- Place of Presentation
  Korea
- Data Source
  KAKENHI-PROJECT-19590785
[Presentation] Differentiation of ACLF from ALF, SAHF and CLF. APASL working party on acute on chronic livfailure2008
- Author(s)
  Takikawa Y, Suzuki K.
- Organizer
  Live-data share and consensus developing meeting. New Delhi
- Place of Presentation
  India
- Data Source
  KAKENHI-PROJECT-19590785
[Presentation] Five cases with ACLF. APASL working party on acute on chronic liver failure. Live-data share and consensus developing meeting2008
- Author(s)
  Takikawa Y, Suzuki K.
- Organizer
  New Delhi
- Place of Presentation
  India
- Data Source
  KAKENHI-PROJECT-19590785
[Presentation] Fulminant Hepatic failure plasma suppressescell proliferation and activates JNK phosphorylation in mouse liver stemstem/progenitor cells2008
- Author(s)
  Kakisaka K, Takikawa Y, lnoue E, Onoder a M, Lin SD, Suzuki K
- Organizer
  AASLD San Francisco
- Place of Presentation
  USA
- Data Source
  KAKENHI-PROJECT-19590785
[Presentation] Significance of a novel biomarker for hepatocellular apoptosis (caspase 3-cleaved cytokeratin-18 pruduct)in acute and fulminant hepatic injury.2007
- Author(s)
  Yasumi Y, Takikawa Y, Watanabe Y, Sato A, Endo R, Suzuki T.
- Organizer
  Digestive Disease Week USA
- Place of Presentation
  Washington DC
- Year and Date
  2007-05-21
- Data Source
  KAKENHI-PROJECT-19590785
[Presentation] The Effect of Artificial Liver Support on Acute Liver Failure.2007
- Author(s)
  Takikawa Y, Suzuki T.
- Organizer
  Asia Pacific Digestive Disease Week
- Place of Presentation
  神戸
- Year and Date
  2007-10-16
- Data Source
  KAKENHI-PROJECT-19590785
[Presentation] The Effect of Artificial Liver Support on Acute Liver Failure2007
- Author(s)
  Takikawa Y, Suzuki T.
- Organizer
  APDW
- Place of Presentation
  於神戸
- Year and Date
  2007-10-16
- Data Source
  KAKENHI-PROJECT-19590785
[Presentation] Clinical epidemiology of fulminant hepatitis in Japan2007
- Author(s)
  Takikawa Y, Suzuki T
- Organizer
  6^<th> JSH Single Topic Conference
- Place of Presentation
  盛岡
- Year and Date
  2007-09-28
- Data Source
  KAKENHI-PROJECT-19590785
[Presentation] Clinical epidemiology of fulminant hepatitis in Japan2007
- Author(s)
  Takikawa Y, Suzuki T.
- Organizer
  The 6^<th> Japanese Society of Hepatology Single Topic Conference
- Place of Presentation
  盛岡・安比
- Year and Date
  2007-09-28
- Data Source
  KAKENHI-PROJECT-19590785
[Presentation] Lysosome dysfunction contributes impairment of autophagy in mouse model of liver steatosis.
- Author(s)
  A. Suzuki, K. Kakisaka, A. Watanabe, T. Wang, Y. Takikawa
- Organizer
  ＡＡＳＬＤ
- Place of Presentation
  Boston
- Year and Date
  2014-11-07 – 2014-11-11
- Data Source
  KAKENHI-PROJECT-24590992
[Presentation] 急性肝障害・急性肝不全における血清AFPの意義：生体肝移植ドナーとの比較．
- Author(s)
  1)柿坂啓介，片岡晃二郎，小野寺美緒，舘道芳徳，及川寛太，滝川康裕
- Organizer
  第100回日本消化器病学会総会
- Place of Presentation
  東京
- Year and Date
  2014-04-23 – 2014-04-26
- Data Source
  KAKENHI-PROJECT-25461008

1. WANG Tei (70416171)

# of Collaborated Projects: 6 results

# of Collaborated Products: 22 results
2. SUZUKI Kazuyuki (00137499)

# of Collaborated Projects: 4 results

# of Collaborated Products: 9 results
3. Kakisaka Keisuke (40583563)

# of Collaborated Projects: 4 results

# of Collaborated Products: 39 results
4. 鈴木悠地 (00779332)

# of Collaborated Projects: 3 results

# of Collaborated Products: 27 results
5. KATO Akinobu (50177424)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. MAESAWA Chihaya (10326647)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
7. MIYASAKA Akio (80382597)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
8. ENDO Ryujin (70316355)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. SAWARA Kei (40405816)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
10. SATO Shunichi (10048275)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. ABE Koichi (90285586)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 渡辺雄輝 (00405771)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 及川寛太 (00405804)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
14. 佐藤慎一郎 (70326669)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. ITOH Tohru

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 及川浩樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 石田和之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 西塚哲

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 宮島篤

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 黒田英克

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 菅井有

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

TAKIKAWA Yasuhiro 滝川 康裕

Research Projects

Research Products

Co-Researchers

Investigation of an optimal environment for the proliferation of mature hepatocytes toward the rescue of acute liver failure patientsPrincipal Investigator

Principal Investigator

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Regulation of non-apoptotic cell death to treat non-alcoholic steatohepatitis

Principal Investigator

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Review Section

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The study for the proliferation mechanism of functional hepatocyte to address the impaired liver regeneration syndromePrincipal Investigator

Principal Investigator

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Regulation of transforming growth factor is involved in the efficacy of combined 5-fluorouracil and interferon alpha-2b therapy of advanced hepatocellular carcinoma

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Study on the proliferation mechanism of mature and progenitor hepatocytes for the treatment of impaired regeneration of the liverPrincipal Investigator

Principal Investigator

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Clarifying the molecular mechanism of the Nrf-2 activator carnosic acid in the regulation of the hepatocyte apoptosis

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Influence of interferon on the functional and structural changes of central nervous system from the viewpoints of aging and gender

Principal Investigator

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Identification and characterization of hepatocyte regenerativefactor in the plasma of patients with fulminant hepatitisPrincipal Investigator

Principal Investigator

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肝性脳症における時計遺伝子の発現動態に関する検討

Principal Investigator

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Study for implication of apoptotic mechanism in massive hepatic cell death and its controlPrincipal Investigator

Principal Investigator

Project Period (FY)

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Research Institution

Clinical and experimental study for regulation of apoptosis and necrosis in acute liver failure

Principal Investigator

Project Period (FY)

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Research Institution

Reassessment of the pathogenesis and the management of hepatic encephalopathy : include the cases of subclinical hepatic encephalopathy

Principal Investigator

Project Period (FY)

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Research Institution

[Book] Muse cells: A New Era of Pluripotent Stem Cells2018

Author(s)

Total Pages

Publisher

TAKIKAWA Yasuhiro 滝川康裕

[Journal Article] Regulation of transforming　growth factor is involved in the efficacy of combined 5-fluorouracil and　interferon alpha-2b therapy of advanced hepatocellular carcinoma2018