) 王挺

… Alternative Names

Researcher Number	70416171
Affiliation (Current)	2018 : 岩手医科大学, 医学部, 助教
Affiliation (based on the past Project Information) *help	2019 : 岩手医科大学, 付置研究所, 講師 2009 – 2017 : 岩手医科大学, 医学部, 助教 2015 : 岩手医科大学, 内科学講座消化器内科肝臓分野, 助教
Review Section/Research Field	Principal Investigator Gastroenterology / Basic Section 50020:Tumor diagnostics and therapeutics-related Except Principal Investigator Gastroenterology
Keywords	Principal Investigator 5-FU / IFN/5-FU 併用療法 / ERK1/2 / Claudin-1 / アポトーシス / E-cadherin / カルノシン酸 / 細胞死 / TGF-β / シグナル … More Except Principal Investigator 薬物反応 / 血清遊離脂肪酸 / 増殖環境 / 細胞・祖時期 / 急性肝不全 / カルニチン / 偽胆管 / アンモニア / 細胞・組織 / 肝炎ウイルス / アルファフェトプロテイン / 肝硬変 / ウイルス / アストロサイト / シグナル伝達 / 肝再生 / インターフェロン / AFP / 薬剤反応 / 肝前駆細胞 / 肝性脳症 / ミニマル肝性脳症 Less

TGF-βシグナルの調節機構に基づいた進行肝癌のオーダーメイド化学療法の開発Principal InvestigatorOngoing
- Principal Investigator
  
  王挺
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Iwate Medical University
Regulation of transforming growth factor is involved in the efficacy of combined 5-fluorouracil and interferon alpha-2b therapy of advanced hepatocellular carcinomaPrincipal Investigator
- Principal Investigator
  
  WANG TING
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Iwate Medical University
Study on the proliferation mechanism of mature and progenitor hepatocytes for the treatment of impaired regeneration of the liver
- Principal Investigator
  
  Takikawa Yasuhiro
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Iwate Medical University
Experimental and clinical studies on the effects of L-carnitine in minimal hepatic encephalopathy
- Principal Investigator
  
  Suzuki kazuyuki
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Iwate Medical University
Clarifying the molecular mechanism of the Nrf-2 activator carnosic acid in the regulation of the hepatocyte apoptosisPrincipal Investigator
- Principal Investigator
  
  WANG TING
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Iwate Medical University
Influence of interferon on the functional and structural changes of central nervous system from the viewpoints of aging and gender
- Principal Investigator
  
  SUZUKI Kazuyuki
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Iwate Medical University

All 2018 2017 2016 2015 2014 2013 2012 2011 Other

All Journal Article Presentation

[Journal Article] Regulation of transforming　growth factor is involved in the efficacy of combined 5-fluorouracil and　interferon alpha-2b therapy of advanced hepatocellular carcinoma2018
- Author(s)
  Okada Y, Wang T, Kasai K, Suzuki K, Takikawa Y.
- Journal Title
  
  Cell Death　Discov.
  
  Volume : 12 Pages : 40-42
- DOI
  10.1038/s41420-018-0040-y
- Open Access / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09020
[Journal Article] c-Jun N-terminal kinase-mediated Rubicon expression enhances hepatocyte lipoapoptosis and promotes hepatocyte ballooning.2016
- Author(s)
  Suzuki A, Kakisaka K, Suzuki Y, Wang T, Takikawa Y.
- Journal Title
  
  World journal of Gastroenterology
  
  Volume : 22 Pages : 6509-19
- DOI
  10.3748/wjg.v22.i28.6509
- Open Access / Acknowledgement Compliant / Int'l Joint Research / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09020, KAKENHI-PROJECT-16K21307
[Journal Article] Carnosic acid protects normal mouse hepatocytes against H2O2 -induced cytotoxicity via sirtuin 1-mediated signaling.2016
- Author(s)
  Wang T, Takikawa Y.
- Journal Title
  
  Hepatol Res.
  
  Volume : 46 Pages : 239-46
- DOI
  10.1111/hepr.12563
- Open Access / Acknowledgement Compliant / Int'l Joint Research / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09020
[Journal Article] Ductular reactions in the liver regeneration process with local inflammation after physical partial hepatectomy.2016
- Author(s)
  Suzuki Y, Katagiri H, Wang T, Kakisaka K, Kume K, Nishizuka SS, Takikawa Y.
- Journal Title
  
  Lab Invest
  
  Volume : 96 Pages : 1211-22
- DOI
  10.1038/labinvest.2016.97
- Open Access / Acknowledgement Compliant / Int'l Joint Research / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09020, KAKENHI-PROJECT-16K09370
[Journal Article] Dietary supplementation with evodiamine preventsrrnt ovbeity and improive insuli resisetnance in ageing mice.2015
- Author(s)
  2.Yamashita H, Kusudo T, Takeuchi T, Qiao SL, Tsutsumiuchi K, Wang T, Wang YX.
- Journal Title
  
  Journal of functional foods.
  
  Volume : 19 Pages : 320-329
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09020
[Journal Article] Proliferation of mouse liver stem/progenitor cells induced by plasma from2015
- Author(s)
  Wang T, Takikawa Y, Watanabe A, Kakisaka K, Oikawa K, Miyamoto Y, and Suzuki K
- Journal Title
  
  J Gastroenterol.
  
  Volume : 49 Pages : 1557-1566
- DOI
  10.1007/s00535-013-0927-6
- Open Access / Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461009, KAKENHI-PROJECT-24590992, KAKENHI-PROJECT-25461008
[Journal Article] The usefulness and accuracy of international normalized ratio (INR) and activity percent of prothrombin time in patients with liver disease.2014
- Author(s)
  Takikawa Y, Harada M, Wang T, Suzuki K.
- Journal Title
  
  Hepatol Res
  
  Volume : 44 Pages : 92-101
- DOI
  10.1111/hepr.12093
- Open Access / Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590992, KAKENHI-PROJECT-25461008, KAKENHI-PROJECT-25461009
[Journal Article] Evodiamine Inhibits Insulin-Stimulated mTOR-S6K Activation and IRS1 Serine Phosphorylation in Adipocytes and Improves Glucose Tolerance in Obese/Diabetic Mice.2013
- Author(s)
  Wang T, Kusudo T, Takeuchi T, Yamashita Y, Kontani Y, Okamatsu Y, Saito M, Mori N, Yamashita H.
- Journal Title
  
  PLoS One.
  
  Volume : ８
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590992
[Journal Article] Proliferation of mouse liver stem/progenitor cells induced by plasma from patients with acute liver failure is modulated by P2Y2 receptor-mediated JNK activation.2013
- Author(s)
  Wang T, Takikawa Y, Watanabe A, Kakisaka K, Oikawa K, Miyamoto Y, Suzuki K.
- Journal Title
  
  J Gastroenterol.
  
  Volume : Epub ahead of print
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590992
[Journal Article] FGF7 is a functional niche signal required for stimulation of adult liver progenitor cells that support liver regeneration.2013
- Author(s)
  Takase HM, Itoh T, Ino S, Wang T, Koji T, Akira S, Takikawa Y, Miyajima A.
- Journal Title
  
  Genes Dev
  
  Volume : 27 Pages : 169-181
- DOI
  10.1101/gad.204776.112
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590342, KAKENHI-PROJECT-25461008, KAKENHI-PUBLICLY-24112507
[Journal Article] Carnosic acid prevents lipid accumulation in hepatocytes through EGF/MAPK pathway2012
- Author(s)
  Wang T, Takikawa Y, Tabuchi T, Kosaka K, Satoh T, Suzuki K. .
- Journal Title
  
  J Gastroenterol
  
  Volume : 47 Pages : 805-13
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590992
[Journal Article] Negative regulation of human astrocytes by Interferon (IFN) α in relation to growth inhibition and impaired glucose utilization.2012
- Author(s)
  Wang T, TakikawaY, Sawara K, YoshidaY, Suzuki K.
- Journal Title
  
  Neurochem Res
  
  Volume : 37 Pages : 1898-905
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590992
[Journal Article] Negative regulation of human astrocytes by IFNα: the involvement of growth inhibition and impaired glucose utilization2012
- Author(s)
  Wang T, Takikawa Y, Sawara K, Yoshida S, Suzuki K
- Journal Title
  
  Neurochem Res
  
  Volume : (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590857
[Presentation] The effects of 5-fluorouracil (5-FU) on TGF-β-related signaling molecules2017
- Author(s)
  Wang T, Takikawa Y.
- Organizer
  European Society for Medical Oncology　（ＥＳＭＯ）　２０１７　Ｃｏｎｇｒｅｓｓ
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09020
[Presentation] Anti-tumor effect of Carnosic acid on human hepatoma cell lines2017
- Author(s)
  wang T, Takikawa Y.
- Organizer
  The APASL Single Topic Conference in Nagasaki
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09020
[Presentation] カルノシン酸による肝癌細胞株の細胞死の促進メカニズムの検討2016
- Author(s)
  王挺
- Organizer
  第52回日本肝癌研究会
- Place of Presentation
  東京　虎ノ門ヒルズフォーラム
- Year and Date
  2016-07-01
- Data Source
  KAKENHI-PROJECT-15K09020
[Presentation] Effects of 5-fluorouracil (5-FU) combined with interferon alpha (IFNα)-2b on the protein expression and secretion of TGFβ2016
- Author(s)
  TING WANG
- Organizer
  ILCA
- Place of Presentation
  Vancouver, Canada
- Year and Date
  2016-09-09
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09020
[Presentation] L-carnitine prevents ammonia-induced cytotoxicity on human astrocytes: Results of metabolome analysis2015
- Author(s)
  Kazuyuki Suzuki, Ting Wang, Keisuke Kakisaka, Kei Sawara, Miho Onodera, Hidekatsu Kuroda, Ryujin Endo, Akinobu Kato, and Yasuhiro Takikawa
- Organizer
  ASSLD
- Place of Presentation
  Chicago, USA
- Year and Date
  2015-10-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461009
[Presentation] Carnosic acid protects against oxidative stress-induced cytotoxicity in primary hepatocytes, induces tumor cell death, and inhibits TGFβ-induced migration and invasion in HepG2 cells.2013
- Author(s)
  Takikawa Y、Wang T, Watanabe A, Kakisaka K, Onodera M, Oikawa K.
- Organizer
  AASLD
- Place of Presentation
  Washington DC.
- Data Source
  KAKENHI-PROJECT-24590992
[Presentation] IFN-α/5-FU併用によるTGFβシグナルへの影響2013
- Author(s)
  王挺、滝川康裕、葛西和博、渡辺亜沙子、鈴木一幸。
- Organizer
  第49回肝臓学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24590992
[Presentation] IFN-α/5-FU併用によるTGFβの発現量および分泌量変化への影響2012
- Author(s)
  王挺
- Organizer
  JDDW　2012
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-24590992
[Presentation] Interferon-α inhibits the proliferation of human astrocyte and decrease the expression glucose transporter Glut-12011
- Author(s)
  Wang T, Takikawa Y, Yoshida S, Sawara K, Suzuki K
- Organizer
  22^<st> APDW
- Place of Presentation
  Singapore, Malaysia
- Year and Date
  2011-10-07
- Data Source
  KAKENHI-PROJECT-21590857
[Presentation] Lysosome dysfunction contributes impairment of autophagy in mouse model of liver steatosis.
- Author(s)
  A. Suzuki, K. Kakisaka, A. Watanabe, T. Wang, Y. Takikawa
- Organizer
  ＡＡＳＬＤ
- Place of Presentation
  Boston
- Year and Date
  2014-11-07 – 2014-11-11
- Data Source
  KAKENHI-PROJECT-24590992
[Presentation] 肝硬変におけるミニマル肝性脳症の罹患率とその診断的予測因子の検索
- Author(s)
  小野寺美緒、鈴木一幸、黒田英克、小岡洋平、佐原　圭、王　挺、及川隆喜、遠藤龍人、滝川康裕、加藤章信
- Organizer
  第51回日本肝臓学会総会
- Place of Presentation
  熊本市
- Year and Date
  2015-05-21 – 2015-05-22
- Data Source
  KAKENHI-PROJECT-25461009

1. TAKIKAWA Yasuhiro (50254751)

# of Collaborated Projects : 4results

# of Collaborated Products : 17results
2. SUZUKI Kazuyuki (00137499)

# of Collaborated Projects : 2results

# of Collaborated Products : 6results
3. SAWARA Kei (40405816)

# of Collaborated Projects : 2results

# of Collaborated Products : 4results
4. MIYASAKA Akio (80382597)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
5. Kakisaka Keisuke (40583563)

# of Collaborated Projects : 2results

# of Collaborated Products : 4results
6. Kuroda Hidekatsu

# of Collaborated Projects : 1results

# of Collaborated Products : 2results
7. Kato Akinobu

# of Collaborated Projects : 1results

# of Collaborated Products : 2results
8. 伊藤暢

# of Collaborated Projects : 0results

# of Collaborated Products : 1results

) 王 挺

王 挺 オウ テイ

WANG Tei 王 挺

Research Projects

Research Products

Co-Researchers

TGF-βシグナルの調節機構に基づいた進行肝癌のオーダーメイド化学療法の開発Principal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Regulation of transforming growth factor is involved in the efficacy of combined 5-fluorouracil and interferon alpha-2b therapy of advanced hepatocellular carcinomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study on the proliferation mechanism of mature and progenitor hepatocytes for the treatment of impaired regeneration of the liver

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Experimental and clinical studies on the effects of L-carnitine in minimal hepatic encephalopathy

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Clarifying the molecular mechanism of the Nrf-2 activator carnosic acid in the regulation of the hepatocyte apoptosisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Influence of interferon on the functional and structural changes of central nervous system from the viewpoints of aging and gender

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Regulation of transforming growth factor is involved in the efficacy of combined 5-fluorouracil and interferon alpha-2b therapy of advanced hepatocellular carcinoma2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] c-Jun N-terminal kinase-mediated Rubicon expression enhances hepatocyte lipoapoptosis and promotes hepatocyte ballooning.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Carnosic acid protects normal mouse hepatocytes against H2O2 -induced cytotoxicity via sirtuin 1-mediated signaling.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Ductular reactions in the liver regeneration process with local inflammation after physical partial hepatectomy.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Dietary supplementation with evodiamine preventsrrnt ovbeity and improive insuli resisetnance in ageing mice.2015

Author(s)

Journal Title

Data Source

[Journal Article] Proliferation of mouse liver stem/progenitor cells induced by plasma from2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The usefulness and accuracy of international normalized ratio (INR) and activity percent of prothrombin time in patients with liver disease.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Evodiamine Inhibits Insulin-Stimulated mTOR-S6K Activation and IRS1 Serine Phosphorylation in Adipocytes and Improves Glucose Tolerance in Obese/Diabetic Mice.2013

Author(s)

Journal Title

Data Source

) 王挺

王挺オウテイ

WANG Tei 王挺

[Journal Article] Regulation of transforming　growth factor is involved in the efficacy of combined 5-fluorouracil and　interferon alpha-2b therapy of advanced hepatocellular carcinoma2018