WANG Tei 王挺

… Alternative Names

Researcher Number	70416171
Affiliation (Current)	2022: 岩手医科大学, 歯学部, 特任講師
Affiliation (based on the past Project Information) *help	2020: 岩手医科大学, 歯学部, 特任講師 2019 – 2020: 岩手医科大学, 医歯薬総合研究所, 特任講師 2009 – 2017: 岩手医科大学, 医学部, 助教 2015: 岩手医科大学, 内科学講座消化器内科肝臓分野, 助教
Review Section/Research Field	Principal Investigator Gastroenterology / Basic Section 50020:Tumor diagnostics and therapeutics-related Except Principal Investigator Gastroenterology / Basic Section 53010:Gastroenterology-related
Keywords	Principal Investigator TGF-β / カルノシン酸 / シグナル / アポトーシス / 酸化ストレス / 細胞死 / Carnosic acid / Nrf2 / Oxidative stress / IFN/5-FU 併用療法 … More Except Principal Investigator 肝再生 / 急性肝不全 / ウイルス / インターフェロン / 薬剤反応 / 細胞・組織 / シグナル伝達 / 肝炎ウイルス / 薬物反応 / 細胞・祖時期 / 肝前駆細胞 / AFP / アルファフェトプロテイン / 偽胆管 / 増殖環境 / カルニチン / ミニマル肝性脳症 / 肝硬変 / アンモニア / 血清遊離脂肪酸 / アストロサイト / 肝性脳症 / 細胆管反応 / 類洞内皮 / 血管内皮細胞増殖因子 / サイトカイン Less

Development of personalized chemotherapy for hepatocellular carcinoma: Targeting TGF-b signalingPrincipal Investigator
- Principal Investigator
  
  王挺
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Iwate Medical University
急性肝不全救命に向けた成熟肝細胞の至適増殖環境の解明
- Principal Investigator
  
  滝川康裕
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Iwate Medical University
Regulation of transforming growth factor is involved in the efficacy of combined 5-fluorouracil and interferon alpha-2b therapy of advanced hepatocellular carcinomaPrincipal Investigator
- Principal Investigator
  
  WANG TING
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Iwate Medical University
Study on the proliferation mechanism of mature and progenitor hepatocytes for the treatment of impaired regeneration of the liver
- Principal Investigator
  
  Takikawa Yasuhiro
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Iwate Medical University
Experimental and clinical studies on the effects of L-carnitine in minimal hepatic encephalopathy
- Principal Investigator
  
  Suzuki kazuyuki
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Iwate Medical University
Clarifying the molecular mechanism of the Nrf-2 activator carnosic acid in the regulation of the hepatocyte apoptosisPrincipal Investigator
- Principal Investigator
  
  WANG TING
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Iwate Medical University
Influence of interferon on the functional and structural changes of central nervous system from the viewpoints of aging and gender
- Principal Investigator
  
  SUZUKI Kazuyuki
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Iwate Medical University

All 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 Other

All Journal Article Presentation

[Journal Article] ALDH2 genotype modulates the association between alcohol consumption and AST/ALT ratio among middle-aged Japanese men : a genome-wide G × E interaction analysis2020
- Author(s)
  Yoichi Sutoh, Tsuyoshi Hachiya, Yuji Suzuki, Shohei Komaki, Hideki Ohmomo, Keisuke Kakisaka, Ting Wang, Yasuhiro Takikawa & Atsushi Shimizu
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Pages: 16227-16227
- DOI
  10.1038/s41598-020-73263-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07737, KAKENHI-PROJECT-16H06277
[Journal Article] L-carnitine prevents ammonia-induced cytotoxicity and disturbances in intracellular amino acid levels in human astrocytes.2019
- Author(s)
  Wang Ting、Suzuki Kazuyuki、Kakisaka Keisuke、Onodera Mio、Sawara Kei、Takikawa Yasuhiro
- Journal Title
  
  J Gastroenterol Hepatol.
  
  Volume: - Pages: 1249-1255
- DOI
  10.1111/jgh.14497
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K19346, KAKENHI-PROJECT-19K08475
[Journal Article] Next-generation sequencing analysis of the human T-cell and B-cell receptor repertoire diversity before and after2019
- Author(s)
  Miyasaka A, Yoshida Y, Wang T, Takikawa Y
- Journal Title
  
  Hum Vaccin Immunother
  
  Volume: 25 Pages: 1-16
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07737
[Journal Article] IL-8 induces transdifferentiation of mature hepatocytes toward the cholangiocyte phenotype.2019
- Author(s)
  Sasaki T, Suzuki Y, Kakisaka K, Wang T, Ishida K, Suzuki A, Abe H, Sugai T, Takikawa Y
- Journal Title
  
  FEBS Open Bio.
  
  Volume: 0 Pages: 0-0
- DOI
  10.1002/2211-5463.12750
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07737, KAKENHI-PROJECT-19K08475, KAKENHI-PROJECT-17K08700, KAKENHI-PROJECT-18K15825
[Journal Article] Regulation of transforming　growth factor is involved in the efficacy of combined 5-fluorouracil and　interferon alpha-2b therapy of advanced hepatocellular carcinoma2018
- Author(s)
  Okada Y, Wang T, Kasai K, Suzuki K, Takikawa Y.
- Journal Title
  
  Cell Death　Discov.
  
  Volume: 12 Pages: 40-42
- DOI
  10.1038/s41420-018-0040-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09020
[Journal Article] c-Jun N-terminal kinase-mediated Rubicon expression enhances hepatocyte lipoapoptosis and promotes hepatocyte ballooning.2016
- Author(s)
  Suzuki A, Kakisaka K, Suzuki Y, Wang T, Takikawa Y.
- Journal Title
  
  World journal of Gastroenterology
  
  Volume: 22 Pages: 6509-19
- DOI
  10.3748/wjg.v22.i28.6509
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09020, KAKENHI-PROJECT-16K21307
[Journal Article] Carnosic acid protects normal mouse hepatocytes against H2O2 -induced cytotoxicity via sirtuin 1-mediated signaling.2016
- Author(s)
  Wang T, Takikawa Y.
- Journal Title
  
  Hepatol Res.
  
  Volume: 46 Pages: 239-46
- DOI
  10.1111/hepr.12563
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09020
[Journal Article] Ductular reactions in the liver regeneration process with local inflammation after physical partial hepatectomy.2016
- Author(s)
  Suzuki Y, Katagiri H, Wang T, Kakisaka K, Kume K, Nishizuka SS, Takikawa Y.
- Journal Title
  
  Lab Invest
  
  Volume: 96 Pages: 1211-1222
- DOI
  10.1038/labinvest.2016.97
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09020, KAKENHI-PROJECT-16K09370
[Journal Article] Dietary supplementation with evodiamine preventsrrnt ovbeity and improive insuli resisetnance in ageing mice.2015
- Author(s)
  2.Yamashita H, Kusudo T, Takeuchi T, Qiao SL, Tsutsumiuchi K, Wang T, Wang YX.
- Journal Title
  
  Journal of functional foods.
  
  Volume: 19 Pages: 320-329
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09020
[Journal Article] Proliferation of mouse liver stem/progenitor cells induced by plasma from patients with acute liver failure is modulated by P2Y receptor-mediated JNK activation.2015
- Author(s)
  Wang T, Takikawa Y, Watanabe A, Kakisaka K, Oigawa K, Miyamoto Y, Suzuki K.
- Journal Title
  
  J Gastroenterol
  
  Volume: 49 Pages: 1557-1566
- DOI
  10.1007/s00535-013-0927-6
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24590992, KAKENHI-PROJECT-25461008, KAKENHI-PROJECT-25461009
[Journal Article] The usefulness and accuracy of international normalized ratio (INR) and activity percent of prothrombin time in patients with liver disease.2014
- Author(s)
  Takikawa Y, Harada M, Wang T, Suzuki K.
- Journal Title
  
  Hepatology Research
  
  Volume: 44 Pages: 92-101
- DOI
  10.1111/hepr.12093
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24590992, KAKENHI-PROJECT-25461008, KAKENHI-PROJECT-25461009
[Journal Article] Evodiamine Inhibits Insulin-Stimulated mTOR-S6K Activation and IRS1 Serine Phosphorylation in Adipocytes and Improves Glucose Tolerance in Obese/Diabetic Mice.2013
- Author(s)
  Wang T, Kusudo T, Takeuchi T, Yamashita Y, Kontani Y, Okamatsu Y, Saito M, Mori N, Yamashita H.
- Journal Title
  
  PLoS One.
  
  Volume: ８
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590992
[Journal Article] Proliferation of mouse liver stem/progenitor cells induced by plasma from patients with acute liver failure is modulated by P2Y2 receptor-mediated JNK activation.2013
- Author(s)
  Wang T, Takikawa Y, Watanabe A, Kakisaka K, Oikawa K, Miyamoto Y, Suzuki K.
- Journal Title
  
  J Gastroenterol.
  
  Volume: Epub ahead of print
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590992
[Journal Article] FGF7 is a functional niche signal required for stimulation of adult liver progenitor cells that support liver regeneration2013
- Author(s)
  Takase HM, Itoh T, Ino S, Wang T, Koji T, Akira S, Takikawa Y, Miyajima A.
- Journal Title
  
  Genes Development
  
  Volume: 27 Pages: 169-181
- DOI
  10.1101/gad.204776.112
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590342, KAKENHI-PROJECT-25461008, KAKENHI-PLANNED-22118006, KAKENHI-PUBLICLY-24112507
[Journal Article] Carnosic acid prevents lipid accumulation in hepatocytes through EGF/MAPK pathway2012
- Author(s)
  Wang T, Takikawa Y, Tabuchi T, Kosaka K, Satoh T, Suzuki K. .
- Journal Title
  
  J Gastroenterol
  
  Volume: 47 Pages: 805-13
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590992
[Journal Article] Negative regulation of human astrocytes by Interferon (IFN) α in relation to growth inhibition and impaired glucose utilization.2012
- Author(s)
  Wang T, TakikawaY, Sawara K, YoshidaY, Suzuki K.
- Journal Title
  
  Neurochem Res
  
  Volume: 37 Pages: 1898-905
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590992
[Journal Article] Negative regulation of human astrocytes by IFNα: the involvement of growth inhibition and impaired glucose utilization2012
- Author(s)
  Wang T, Takikawa Y, Sawara K, Yoshida S, Suzuki K
- Journal Title
  
  Neurochem Res
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590857
[Presentation] 肝性脳症に対するBCAA とカルニチンの併用療法の合理性に関する基礎的検討2020
- Author(s)
  王挺
- Organizer
  第43回日本肝臓学会東部会
- Data Source
  KAKENHI-PROJECT-19K07737
[Presentation] IL-8は成熟肝細胞において胆管上皮細胞の表現型を誘導する．2019
- Author(s)
  佐々木登希夫，鈴木悠地，王挺，柿坂啓介，滝川康裕．
- Organizer
  第45回日本急性肝不全研究会
- Data Source
  KAKENHI-PROJECT-19K08475
[Presentation] The effects of 5-fluorouracil (5-FU) on TGF-β-related signaling molecules2017
- Author(s)
  Wang T, Takikawa Y.
- Organizer
  European Society for Medical Oncology　（ＥＳＭＯ）　２０１７　Ｃｏｎｇｒｅｓｓ
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09020
[Presentation] Anti-tumor effect of Carnosic acid on human hepatoma cell lines2017
- Author(s)
  wang T, Takikawa Y.
- Organizer
  The APASL Single Topic Conference in Nagasaki
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09020
[Presentation] カルノシン酸による肝癌細胞株の細胞死の促進メカニズムの検討2016
- Author(s)
  王挺
- Organizer
  第52回日本肝癌研究会
- Place of Presentation
  東京　虎ノ門ヒルズフォーラム
- Year and Date
  2016-07-01
- Data Source
  KAKENHI-PROJECT-15K09020
[Presentation] Effects of 5-fluorouracil (5-FU) combined with interferon alpha (IFNα)-2b on the protein expression and secretion of TGFβ2016
- Author(s)
  TING WANG
- Organizer
  ILCA
- Place of Presentation
  Vancouver, Canada
- Year and Date
  2016-09-09
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09020
[Presentation] L-carnitine prevents ammonia-induced cytotoxicity on human astrocytes: Results of metabolome analysis2015
- Author(s)
  Kazuyuki Suzuki, Ting Wang, Keisuke Kakisaka, Kei Sawara, Miho Onodera, Hidekatsu Kuroda, Ryujin Endo, Akinobu Kato, and Yasuhiro Takikawa
- Organizer
  ASSLD
- Place of Presentation
  Chicago, USA
- Year and Date
  2015-10-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461009
[Presentation] Carnosic acid protects against oxidative stress-induced cytotoxicity in primary hepatocytes, induces tumor cell death, and inhibits TGFβ-induced migration and invasion in HepG2 cells.2013
- Author(s)
  Takikawa Y、Wang T, Watanabe A, Kakisaka K, Onodera M, Oikawa K.
- Organizer
  AASLD
- Place of Presentation
  Washington DC.
- Data Source
  KAKENHI-PROJECT-24590992
[Presentation] IFN-α/5-FU併用によるTGFβシグナルへの影響2013
- Author(s)
  王挺、滝川康裕、葛西和博、渡辺亜沙子、鈴木一幸。
- Organizer
  第49回肝臓学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24590992
[Presentation] IFN-α/5-FU併用によるTGFβの発現量および分泌量変化への影響2012
- Author(s)
  王挺
- Organizer
  JDDW　2012
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-24590992
[Presentation] Interferon-α inhibits the proliferation of human astrocyte and decrease the expression glucose transporter Glut-12011
- Author(s)
  Wang T, Takikawa Y, Yoshida S, Sawara K, Suzuki K
- Organizer
  22^<st> APDW
- Place of Presentation
  Singapore, Malaysia
- Year and Date
  2011-10-07
- Data Source
  KAKENHI-PROJECT-21590857
[Presentation] Lysosome dysfunction contributes impairment of autophagy in mouse model of liver steatosis.
- Author(s)
  A. Suzuki, K. Kakisaka, A. Watanabe, T. Wang, Y. Takikawa
- Organizer
  ＡＡＳＬＤ
- Place of Presentation
  Boston
- Year and Date
  2014-11-07 – 2014-11-11
- Data Source
  KAKENHI-PROJECT-24590992
[Presentation] 肝硬変におけるミニマル肝性脳症の罹患率とその診断的予測因子の検索
- Author(s)
  小野寺美緒、鈴木一幸、黒田英克、小岡洋平、佐原　圭、王　挺、及川隆喜、遠藤龍人、滝川康裕、加藤章信
- Organizer
  第51回日本肝臓学会総会
- Place of Presentation
  熊本市
- Year and Date
  2015-05-21 – 2015-05-22
- Data Source
  KAKENHI-PROJECT-25461009

1. TAKIKAWA Yasuhiro (50254751)

# of Collaborated Projects: 5 results

# of Collaborated Products: 20 results
2. Kakisaka Keisuke (40583563)

# of Collaborated Projects: 3 results

# of Collaborated Products: 8 results
3. SUZUKI Kazuyuki (00137499)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
4. SAWARA Kei (40405816)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
5. MIYASAKA Akio (80382597)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 鈴木悠地 (00779332)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
7. Kuroda Hidekatsu

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
8. Kato Akinobu

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
9. ITOH Tohru

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 菅井有

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 鈴木貞夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 清水厚志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 鈴木康司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 宮島篤

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

WANG Tei 王 挺

王 挺 オウ テイ

Research Projects

Research Products

Co-Researchers

Development of personalized chemotherapy for hepatocellular carcinoma: Targeting TGF-b signalingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

急性肝不全救命に向けた成熟肝細胞の至適増殖環境の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Regulation of transforming growth factor is involved in the efficacy of combined 5-fluorouracil and interferon alpha-2b therapy of advanced hepatocellular carcinomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study on the proliferation mechanism of mature and progenitor hepatocytes for the treatment of impaired regeneration of the liver

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Experimental and clinical studies on the effects of L-carnitine in minimal hepatic encephalopathy

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Clarifying the molecular mechanism of the Nrf-2 activator carnosic acid in the regulation of the hepatocyte apoptosisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Influence of interferon on the functional and structural changes of central nervous system from the viewpoints of aging and gender

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] ALDH2 genotype modulates the association between alcohol consumption and AST/ALT ratio among middle-aged Japanese men : a genome-wide G × E interaction analysis2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] L-carnitine prevents ammonia-induced cytotoxicity and disturbances in intracellular amino acid levels in human astrocytes.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Next-generation sequencing analysis of the human T-cell and B-cell receptor repertoire diversity before and after2019

Author(s)

Journal Title

Data Source

[Journal Article] IL-8 induces transdifferentiation of mature hepatocytes toward the cholangiocyte phenotype.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Regulation of transforming growth factor is involved in the efficacy of combined 5-fluorouracil and interferon alpha-2b therapy of advanced hepatocellular carcinoma2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] c-Jun N-terminal kinase-mediated Rubicon expression enhances hepatocyte lipoapoptosis and promotes hepatocyte ballooning.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Carnosic acid protects normal mouse hepatocytes against H2O2 -induced cytotoxicity via sirtuin 1-mediated signaling.2016

Author(s)

Journal Title

DOI

WANG Tei 王挺

王挺オウテイ

[Journal Article] Regulation of transforming　growth factor is involved in the efficacy of combined 5-fluorouracil and　interferon alpha-2b therapy of advanced hepatocellular carcinoma2018