NAGATOMO Toshihisa 長友敏寿

Researcher Number	50258604
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2007 – 2010: University of Occupational and Environmental Health, Japan, University Hospital, Associate Professor 2006: 産業医科大学, 医学部, 助教授 2005 – 2006: 産業医科大学, 大学病院, 助教授 2001 – 2002: 産業医科大学, 医学部, 助教授 2000: 産業医科大学, 医学部, 講師 1993 – 1995: 産業医科大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Environmental physiology (including Physical medicine and Nutritional physiology) / General physiology Except Principal Investigator Circulatory organs internal medicine / 環境生理学(含体力医学･栄養生理学) / Biological Sciences
Keywords	Principal Investigator Signal transduction / Protein trafficking / Gene / hERG channel / Potassium channel / Sodium channel / long QT syndrome / Electrophysiology / 循環器・高血圧 / 生理学 … More / シグナル伝達 / 蛋白輸送 / 遺伝子 / HERGチャネル / カリウムチャネル / ナトリウムチャネル / QT延長症候群 / 電気生理学 / プロスタグランジンE_2 / 視床下部 / 免疫サイトカイン / シナプス電流 / アンギオテンシンII / 一過性外向き電流 … More Except Principal Investigator orthostatic training / 視床下部 / バゾプレッシン / follow-up / heart rate variability / neurocardiogenic / head-up tilt test / Syncope / Tilt training / head-up tilt試験 / 神経調整性失神 / ホルター心電図 / orthostatic self-training / head-up-tilt試験 / 長期観察 / 心拍変動解析 / 神経調節性失神 / head-up tilt 試験 / 失神 / hypothalamo-pituitary-adrenal axis / adjuvant arthritis / inbred polydipsic mice / paraventricular nucleus / microdialysis / renal sympathetic nerve activity / supraoptic nucleus / cytokine / ストレス / mRNA / c-fos蛋白 / ラットアジュバント関節炎 / 免疫異常 / 遺伝多飲マウス / 視床下部・下垂体・副腎皮質系 / ラットアジュバンド関節炎 / 遺伝性多飲マウス / インビボマイクロダイアリーシス / 自律神経 / 室傍核 / 視索上核 / サイトカイン / サリューシン / アンジオテンシンII / シナプス入力 / パッチクランプ法 / グレリン / ホルモン / GFP / TRP / シチプス / 神経ペプチド / 生体分子 / モーダルシフト / 時計遺伝子 / 視交叉上核 / トランスジェニック動物 / 緑色蛍光タンパク / 生体リズム / 浸透圧 / セルセンサー Less

Functional interactions between hormone-sensor and osmo-sensor in the central regulation of body fluid osmolality
- Principal Investigator
  
  UETA Yoichi
- Project Period (FY)
  2006 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  University of Occupational and Environmental Health, Japan
Intrinsic mechanisms of the ion channels associated with life threatening arrhythmiaPrincipal Investigator
- Principal Investigator
  
  NAGATOMO Toshihisa
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  University of Occupational and Environmental Health, Japan
Investigation of New Therapy with Orthostatic Self-Training and Mechanisms for Neurocardiogenic Syncope
- Principal Investigator
  
  ABE Haruhiko
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  University of Occupational and Environmental Health
免疫サイトカインの視床下部神経分泌細胞に対する作用機序の解明Principal Investigator
- Principal Investigator
  
  長友敏寿
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Environmental physiology (including Physical medicine and Nutritional physiology)
- Research Institution
  University of Occupational and Environmental Health, Japan
視床下部神経分泌ニューロンの膜電流解析及び循環系ペプチドによる膜電流調節Principal Investigator
- Principal Investigator
  
  長友敏寿
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Environmental physiology (including Physical medicine and Nutritional physiology)
- Research Institution
  University of Occupational and Environmental Health, Japan
Role of immunocytokine on the neuroendocrine sysytem
- Principal Investigator
  
  YAMASHITA Hiroshi
- Project Period (FY)
  1992 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  環境生理学(含体力医学･栄養生理学)
- Research Institution
  University of Occupational and Environmental Health

All 2011 2010 2009 2008 2007 2006 2005

All Journal Article Presentation

[Journal Article] Allylisothiocyanates and cinnamaldehyde potentiate miniature excitatory postsynaptic inputs in the sipraoptic nucleus in rats.2011
- Author(s)
  Yokoyama, T., Ohbuchi, T., Saito, T., Fujihara, H., Minami, K., Nagatomo, T., Uezono, Y., Ueta, Y.
- Journal Title
  
  European Journal of Pharmacology 655(1-3)
  
  Pages: 31-37
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18077006
[Journal Article] Allyl isothiocyanates and cinnamaldehyde potentiate miniature excitatory postsynaptic inputs in the sipraoptic nucleus in rats.2011
- Author(s)
  Yokoyama, T.Ohbuchi, T.Saito, T.Fujihara, H.Minami, K.Nagatomo, T.Uezono, Y., Ueta, Y.
- Journal Title
  
  European Journal of Pharmacology
  
  Volume: 655(1-3) Pages: 31-37
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18077006
[Journal Article] TRPV1 gene deficiency attenuates miniature EPSCs potentiation induced by mannitol and angiotensin II in supraoptic magnocellular neurons.2010
- Author(s)
  Yokoyama, T., Saito, T., Ohbuchi, T., Hashimoto, H., Suzuki, H., Otsubo, H., Fujihara, H., Nagatomo, T., Ueta, Y.
- Journal Title
  
  Journal of Neuroscience 30(3)
  
  Pages: 876-884
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18077006
[Journal Article] TRPV1 gene deficiency attenuates miniature EPSCs potentiation induced by mannitol and angiotensin II in supraoptic magnocellular neurons.2010
- Author(s)
  Yokoyama, T.Saito, T.Ohbuchi, T.Hashimoto, H.Suzuki, H.Otsubo, H.Fujihara, H.Nagatomo, T.Ueta, Y
- Journal Title
  
  Journal of Neuroscience
  
  Volume: 30(3) Pages: 876-884
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18077006
[Journal Article] Ghrelin potentiates miniature excitatory postsynaptic currents in rat supraoptic magnocellular neurons.2009
- Author(s)
  Yokoyama, T., Saito, T., Ohbuchi, T., Suzuki, H., Otsubo, H., Okamoto, T., Fujihara, H., Nagatomo, T., Ueta, Y.
- Journal Title
  
  Journal of Neuroendocrinology(Cover article of the issue) 21(11)
  
  Pages: 183-190
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18077006
[Journal Article] Coexistence of hERO current block and disruption of protein trafficking in ketoconazole-induced long QT syndrome.2008
- Author(s)
  Takemasa H, Nagatomo T, Abe H, Kawakami K, Igarashi T, Tsurugi T, Kabashima N, Tamura M, Okazaki M, Delisle BP, January CT, Otsuji Y
- Journal Title
  
  Br J Pharmacol 153
  
  Pages: 439-447
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590194
[Journal Article] Coexistence of hERG current block and disruption of protein trafficking in ketoconazole-induced long QT syndrome2008
- Author(s)
  Takemasa H, Nagatomo T, et. al.
- Journal Title
  
  Br J Pharmacol 153
  
  Pages: 439-447
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590194
[Journal Article] Comparison of HERG channel blocking effects of various β-blockers-implication for clinical strategy2006
- Author(s)
  Kawakami K., Nagatomo T, et. al.
- Journal Title
  
  Br J Pharmacol 147
  
  Pages: 642-52
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590194
[Journal Article] Comparison of HERG channel blocking effects of various β-blockers-implication for clinical strategy.2006
- Author(s)
  Kawakami K, Nagatomo T, Abe H, Kikuchi K, Takemasa H, Anson BD, Delisle BP, January CT, Nakashima Y
- Journal Title
  
  Br J Pharmacol 147
  
  Pages: 642-652
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590194
[Journal Article] Intrinsic mechanism of the enhanced rate-dependent QT shortening in the R1623Q mutant of the LQT3 syndrome.2005
- Author(s)
  Oginosawa Y, Nagatomo T, Abe H, Makita N, Makielski JC, Nakashima Y.
- Journal Title
  
  Cardiovasc Res 65
  
  Pages: 138-47
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590194
[Journal Article] Blockade of HERG cardiac K^+ current by antifungal drug miconazole.2005
- Author(s)
  Kikuchi K, Nagatomo T, Abe H, Kawakami K, Duff HJ, Makielski JC, Januaiy CT, Nakashima Y
- Journal Title
  
  Br J Pharmacol 144
  
  Pages: 840-848
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590194
[Journal Article] Intrinsic mechanism of the enhanced rate-dependent QT shortening in the R1623Q mutant of the LQT3 syndrome2005
- Author(s)
  Oginosawa Y, Nagatomo T, et. al.
- Journal Title
  
  Cardiovasc Res 65
  
  Pages: 138-147
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590194
[Presentation] 視索上核大細胞性神経分泌細胞の浸透圧感受性におけるTRPV1の関与2009
- Author(s)
  横山徹、大淵豊明、藤原広明、長友敏寿、上田陽一
- Organizer
  第32回日本神経科学大会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PLANNED-18077006
[Presentation] TRPA1はラット視索上核大細胞性神経分泌ニューロンへの興奮性シナプス入力を促進する2008
- Author(s)
  横山徹、大淵豊明、藤原広明、長友敏寿、上田陽一
- Organizer
  第36回自律神経生理研究会
- Place of Presentation
  東京
- Year and Date
  2008-12-06
- Data Source
  KAKENHI-PLANNED-18077006
[Presentation] ラット視索上核大細胞性神経分泌ニューロンへのシナプス入力におけるTRPA1の役割:電気生理学的検討2008
- Author(s)
  横山徹、大淵豊明、藤原広明、長友敏寿、上田陽一
- Organizer
  第35回日本神経内分泌学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PLANNED-18077006
[Presentation] ラット視索上核大細胞性神経分泌ニューロンへのシナプス入力におけるTRPA1の役割 : 電気生理学的検討2008
- Author(s)
  横山徹、大淵豊明、藤原広明、長友敏寿、上田陽一
- Organizer
  第35回日本神経内分泌学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PLANNED-18077006
[Presentation] ラット視索上核大細胞性神経分泌ニューロンへの興奮性シナプス入力に対するグレリンの効果2008
- Author(s)
  横山徹、齋藤健、大淵豊明、橋本弘史、鈴木仁士、大坪広樹、藤原広明、長友敏寿、上田陽一
- Organizer
  第85回日本生理学会大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PLANNED-18077006
[Presentation] Coexistence of HERG current block and protein trafficking defect in the drug-induced acquired long QT sylldrome.2007
- Author(s)
  Takemasa H, Nagatomo H, Abe H, Kolmo R, Kawakami K, Tsumgi T, Otsuji Y
- Organizer
  ESC Congress 2007
- Place of Presentation
  Viema, Austria
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590194
[Presentation] Coexistence of HERG current block and protein trafficking defect in the drug-induced acquired long QT syndrome2007
- Author(s)
  Takemasa H, Nagatomo T, et. al.
- Organizer
  ESC Congress 2007
- Place of Presentation
  Vienna,Austria
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590194
[Presentation] Coexistence of HERG current block and protein trafficking defect in the drug-induced acquired long QT syndrome.2006
- Author(s)
  Takemasa H, Nagatomo T, Abe H, Tsurugi T, Kohno R, Otsuji Y
- Organizer
  27th Annual Scientific Session of the Heart khythm Society
- Place of Presentation
  Boston, USA
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590194
[Presentation] Modulation of cardiac sodium channel gating by cAMP in the R1623Q mutamt of the LQT3 syndrome.2006
- Author(s)
  Tsurugi T, Nagatomo T, Abe H, Takemasa H, Kohno R, Nakashima Y
- Organizer
  27th Annual Scientific Session of the Heart khythm Society
- Place of Presentation
  Boston, USA
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590194
[Presentation] Novel intrinsic mechanism of the enhanced rate-dependent QT shorteing in Rl623Q mutant of the LQT3 Syndrome.2005
- Author(s)
  Nagatomo T, Oginosawa Y, Abe H, Tsurgi T, Kikuchi K, Kawakami K, Nakashima Y
- Organizer
  26th Annual Scientific Session of the Heart Rhythm Sociely
- Place of Presentation
  New Orleans, USA
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590194
[Presentation] Comparison of HERG channel blocking effects byβ-blockers-Implication for clinical strategy-2005
- Author(s)
  Kawakami K, Nagatomo T, Kikuchi K, Takemasa H, Oginosawa Y, Tsumgi T, Abe H, Nakashima Y
- Organizer
  26th Annual Scientific Session of the Heart Rhythm Society
- Place of Presentation
  New Orleans, USA
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590194

1. UETA Yoichi (10232745)

# of Collaborated Projects: 2 results

# of Collaborated Products: 10 results
2. ABE Haruhiko (70231967)

# of Collaborated Projects: 2 results

# of Collaborated Products: 9 results
3. FUJIHARA Hiroaki (10369051)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
4. YOKOYAMA Toru (80425321)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
5. YAMASHITA Hiroshi (00030841)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. INENAGA Kiyotoshi (90131903)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. KANNAN Hiroshi (00049058)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. KOHSHI Kiyotaka (90195660)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

NAGATOMO Toshihisa 長友 敏寿

Research Projects

Research Products

Co-Researchers

Functional interactions between hormone-sensor and osmo-sensor in the central regulation of body fluid osmolality

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Intrinsic mechanisms of the ion channels associated with life threatening arrhythmiaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Investigation of New Therapy with Orthostatic Self-Training and Mechanisms for Neurocardiogenic Syncope

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

免疫サイトカインの視床下部神経分泌細胞に対する作用機序の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

視床下部神経分泌ニューロンの膜電流解析及び循環系ペプチドによる膜電流調節Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of immunocytokine on the neuroendocrine sysytem

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Allylisothiocyanates and cinnamaldehyde potentiate miniature excitatory postsynaptic inputs in the sipraoptic nucleus in rats.2011

Author(s)

Journal Title

Data Source

[Journal Article] Allyl isothiocyanates and cinnamaldehyde potentiate miniature excitatory postsynaptic inputs in the sipraoptic nucleus in rats.2011

Author(s)

Journal Title

Data Source

[Journal Article] TRPV1 gene deficiency attenuates miniature EPSCs potentiation induced by mannitol and angiotensin II in supraoptic magnocellular neurons.2010

Author(s)

Journal Title

Data Source

[Journal Article] TRPV1 gene deficiency attenuates miniature EPSCs potentiation induced by mannitol and angiotensin II in supraoptic magnocellular neurons.2010

Author(s)

Journal Title

Data Source

[Journal Article] Ghrelin potentiates miniature excitatory postsynaptic currents in rat supraoptic magnocellular neurons.2009

Author(s)

Journal Title

Data Source

[Journal Article] Coexistence of hERO current block and disruption of protein trafficking in ketoconazole-induced long QT syndrome.2008

Author(s)

Journal Title

Description

Data Source

[Journal Article] Coexistence of hERG current block and disruption of protein trafficking in ketoconazole-induced long QT syndrome2008

Author(s)

Journal Title

Description

Data Source

[Journal Article] Comparison of HERG channel blocking effects of various β-blockers-implication for clinical strategy2006

Author(s)

Journal Title

Description

Data Source

[Journal Article] Comparison of HERG channel blocking effects of various β-blockers-implication for clinical strategy.2006

Author(s)

Journal Title

Description

Data Source

NAGATOMO Toshihisa 長友敏寿