UENO Hikaru 上野光

Researcher Number	50260378
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2000 – 2004: 産業医科大学, 医学部, 教授 2000: Kyushu Univ, Dept of Cardiovasc Med, Assis Prof, 医学部・附属病院, 講師 1999: 九州大学, 大学院・医学部, 講師 1994 – 1999: Kyushu University Assis.Prof., 医学部, 講師 1993: 九州大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Circulatory organs internal medicine / Biological Sciences / Circulatory organs internal medicine / General surgery Except Principal Investigator Circulatory organs internal medicine / Thoracic surgery / Urology / Environmental physiology (including Physical medicine and Nutritional physiology) / Respiratory organ internal medicine / Ophthalmology
Keywords	Principal Investigator 遺伝子治療 / アデノウイルス / 遺伝子導入 / TGF-β / 組換えアデノウイルス / 再狭窄 / gene transfer / PAF-AH / TFPI / H-ras … More / 可溶型受容体 / 腫瘍血管新生 / 血管新生 / 動脈硬化 / injured arteries / inflammation / thrombosis / 血栓症 / 障害血管 / 炎症 / 血栓 / CNP / C-type natriuretic peptide / TGF-b / 傷害血管 / 浸潤 / 転移 / FGF / VEGF / 変異型TGF-β受容体 / 細胞外マトリクス / アデノウィルス / p53 / デリバリーシステム / 留置型ステント / アポトーシス / 癌 / bone marrow-derived progenitor cell / angiopoietin-1 / oxidized lipoproteins / 血管 / 傷害 / 酸化LDL / Angiopoietin-1 / 血小板活性化因子水解酵素(PAF-AH) / 骨髄由来前駆細胞 / アンギオポイエチン-1 / 酸化脂質 / RAF-AH / extracelluar matrix protein / 人工血管 / 抗血栓分子 / 不全心筋 / 糖尿病 / 細胞外基質 / fibrosis / N Ras / D / TEPI / mutated receptors / adenovirus / NFxB / 変異型TGFーβ受容体 / 線維化 / angiogenesis / atherosclerosis / restenosis / gene therapy / recombinant adenovirus / 冠動脈 / 分子生物学 / 動脈硬化症 / 生体内遺伝子導入 / 組み換えアデノウイルス / 形質転換 / クローニング / リボザイムライブラリー / リボザイム / MMP / ヒアルロン酸 / CD44 / 組織因子 / 組織特異性 / 血管新生因子 / アドレノセプター / GTP結合蛋白質 / 張力測定 / スキンド細胞 / 単一心筋細胞 / IKBa / NFkB / VEGF受容体 / Dominan-negative H-Ras / H-Ras / Sdi1 / p21 WAF1 / p53,Cdkl-p21,H-Ras / 心機能 / 心臓発生 / FGF受容体 / 細胞タカルシウム濃度 / レトロウイルス / 細胞増殖因子 / 心筋細胞 … More Except Principal Investigator 遺伝子治療 / 動脈硬化 / 心筋細胞 / nitric oxide / 一酸化窒素 / VEGF / 肥大心 / 微小管 / 細胞骨格 / 不全心 / Flt-1 / Gene transfer / TFPI / Rho-kinase / 組織因子 / アンジオテンシンII / アンジオテンシン変換酵素 / アンギオテンシン変換酵素 / セロトニン / 内皮細胞 / arteriosclerosis / ischemic heart disease / サイトカイン / 冠動脈攣縮 / 虚血性心疾患 / 血管新生 / 心不全 / 心肥大 / Pulmonary hypertension / 遺伝子 / 肺高血圧 / angiogenesis inhibitor / microarray / gene therapy / VEGF receptor / angiogenesis / 腎尿路性器癌 / 膀胱癌 / 腎細胞癌 / 血管新生阻害剤 / マイクロアレイ / VEGF受容体 / Thrombosis / 血栓症 / 静脈グラフト / 血栓予防 / 内膜肥厚 / 障害血管 / GTP-binding Protein / Adenovirus Vector / Myofibrillar Calcium Sensitivity / Contractile Proteins / Heart Failure / 組み換えアデノウィルス / 組み替えアデノウイルス / GTP結合タンパク質 / 組み換えアデノウイルス / カルシウム感受性 / 収縮タンパク質 / regression / coronary vasospasm / signal transduction / coronary artery / arteriosclerossis / 動脈硬化の退縮 / Rhoーkinase / 冠攣縮 / 退縮 / シグナル伝達 / 冠動脈 / fibrosis / inflammation / MCP-1 / NF-κB / gene transfer / 炎症 / ケモカイン / monocyte chemoattractant protein-1 / 転写因子 / 血管内皮 / Elasticity / Viscosity / Microtubules / Cytoskeleton / Heart failure / Hypertrophy / 粘性 / 弾性 / 心筋 / atherosclerosis / thrombosis / angiotensin II / angiotensin-converting enzyme / トロンビン / プラスミノーゲンアクチヴェーター阻害剤 / プラスミノーゲンアクチヴェーター / 一酸化窒素、 / 急性心筋梗塞症 / 冠動脈血栓症 / 血栓 / heat exposure / c-fos / LTP / c-kit mutant rat / hippocampus / Morris water maze / antisense oligodeoxynucleotide / non-RI in situ hybridization / 脾臓マクロファージ / IL-1β / 発熱 / HRP法 / 非放射性cDNAプローブ / mRNA / モリス水迷路 / 海馬 / 肝臓交感神経 / インターロイキン-6 / 拘束ストレス / 暑熱暴露 / paired pulse fancilitation / ミュータントラット / c-fos蛋白 / 長期増強 / c-kit受容体 / 空間認知学習 / アンチセンスオリゴDNA / カルシニューリン / in situハイブリダイゼーション / チミン二量体法 / angiotensin-converting enzyme inhibitor / papaverine / serotonin / coronary circulation / endothelial cell / angina pectoris / 心筋虚血 / 内皮細胞由来一酸化窒素 / 血管内皮細胞 / アンギオテンシン変換酵素阻害薬 / パパベリン / 冠循環 / 狭心症 / myocardial infarction / coronary thrombosis / coronary artery spasm / inflammatory cytokines / 冠□縮 / 冠等縮 / 冠動脈硬化 / 細胞増殖因子 / 心筋梗塞 / 冠動脈血栓 / 炎症性サイトカイン / 可溶型受容体 / 可溶型VEGF受容体 / アデノウィルス / 肺癌 / 血管新生阻害 / アデノウイルスベクター / 可溶性レセプター / TGF-b / ノーザンブロット / カルセクエストリン / Ca^<2+> / 筋小胞体 / サルコメア / 収縮能 / カルシウムイオン / サルコメア長 / 単離心筋細胞標本 / 収縮不全 Less

細胞外マトリクス制御分子群を用いた抗浸潤・転移療法の開発Principal Investigator
- Principal Investigator
  
  上野光
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  University of Occupational and Environmental Health, Japan
ハイブリッド型リボザイムライブラリを用いた新規がん転移関連遺伝子の同定と機能解析Principal Investigator
- Principal Investigator
  
  上野光
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  General surgery
- Research Institution
  University of Occupational and Environmental Health, Japan
Gene transfer-mediated molecular analysis of pathophysiology in injured arteries and development of local anti-inflammatory and anti-thrombotic therapyPrincipal Investigator
- Principal Investigator
  
  UENO Hikaru
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  University of Occupational and Environmental Health
Gene therapy for pulmonary hypertension
- Principal Investigator
  
  NIHSIDA Takahiro
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Thoracic surgery
- Research Institution
  Kyushu University
血管新生抑制分子・転移抑制分子を用いた癌の遺伝子治療法の開発Principal Investigator
- Principal Investigator
  
  上野光
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  University of Occupational and Environmental Health, Japan
組織特異性を有する遺伝子導入ベクター(改変型アデノウイルス)の開発Principal Investigator
- Principal Investigator
  
  上野光
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  University of Occupational and Environmental Health, Japan
血管新生抑制分子・転移抑制分子を用いた固形癌の遺伝子治療法の開発Principal Investigator
- Principal Investigator
  
  上野光
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  University of Occupational and Environmental Health, Japan
Gene transfer-mediated molecular analysis of pathophysiology in injured arteriesPrincipal Investigator
- Principal Investigator
  
  UENO Hikaru
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  University of Occupational and Environmental Health
Basic Research for Gene Therapy of Heart Failure by Transcoronay Gene Transfer
- Principal Investigator
  
  SATOH Shinji
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  KYUSHU UNIVERSITY
Gene therapy for thrombosis
- Principal Investigator
  
  NISHIDA Takahiro
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Thoracic surgery
- Research Institution
  KYUSHU UNIVERSITY
Diagnostic and therapeutic study of angiogenesis in urogenital cancers
- Principal Investigator
  
  ETO Masatoshi, 徳田倫章
- Project Period (FY)
  2000 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  KYUSHU UNIVERSITY
多角的戦略に基づく組換えアデノウィルスによる固形癌の遺伝子治療法の開発Principal Investigator
- Principal Investigator
  
  上野光
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Kyushu University
傷害血管壁再構築におけるTGF-βおよび細胞外マトリクスの動的役割組換えアデノウィルスを利用した血管壁遺伝子導入による分子細胞生物学的解析Principal Investigator
- Principal Investigator
  
  上野光
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Kyushu University
血管新生阻害による肺癌の遺伝子治療
- Principal Investigator
  
  高山浩一
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Kyushu University
成熟心筋細胞収縮機能調整に関する受容体・細部内情報伝達分子機構の解明-組換えアデノウイルスを用いて遺伝子導入した単一成熟心筋細胞を用いた生理機能解析-Principal Investigator
- Principal Investigator
  
  上野光
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Kyushu University
MOLECULAR MECHANISMS OF CARDIOVASCULAR REMODELING INDUCED BY CHRONIC INHIBITION OF NITRIC OXIDE SYNTHESIS : ROLE OF NF-κB AND MCP-1
- Principal Investigator
  
  TAKESHITA Akira
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (A).
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  KYUSHU UNIVERSITY
Development of intracellular therapy to induce a regression of coronary arteriosclerotic lesions
- Principal Investigator
  
  TAKESHITA Akira
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (A).
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  KYUSHU UNIVERSITY
細胞増殖および血管新生抑制分子を発現する組換えアデノウィルスによる癌の遺伝子治療Principal Investigator
- Principal Investigator
  
  上野光
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyushu University
分子生物学的手法を用いた眼内増殖性疾患の治療法の開発
- Principal Investigator
  
  坂本泰二
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  Kyushu University
指向性蛋白含有リポゾームとの結合によるアデノウィルスの細胞選択的導入法の開発-血小板膜糖蛋白GPIbを利用した傷害血管選択的遺伝子導入法の開発-Principal Investigator
- Principal Investigator
  
  上野光
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Kyushu University
Clarification of pathophysiology and development of Gene therapy for inflammatory fibroproliferative arterial DiseasePrincipal Investigator
- Principal Investigator
  
  UENO Hikaru
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  KYUSHU UNIVERSITY
不全心における細胞骨格-細胞外マトリックスと細胞接着分子の役割に関する研究
- Principal Investigator
  
  竹下彰
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyushu University
細胞増殖抑制分子を発現する組換えアデノウイルスによる固形癌の遺伝子治療Principal Investigator
- Principal Investigator
  
  上野光
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyushu University
組換えアデノウイルスを吸着・放出できる冠動脈留置ステントの開発とその応用Principal Investigator
- Principal Investigator
  
  上野光
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Kyushu University
機械的ストレスによる心肥大形成の細胞・分子機構における細胞骨格の役割に関する研究
- Principal Investigator
  
  竹下彰
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyushu University
In vivo roles of growth factors in inflammatory fibroproliferative arterial diseases. -Molecular assessment by in vivo gene transfer into arteries-Principal Investigator
- Principal Investigator
  
  UENO Hikaru
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Kyushu University
molecular mechanisms of vascular thrombosis
- Principal Investigator
  
  TAKESHITA Akira
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  KYUSHU UNIVERSITY
Pathophysiology of diastolic dysfunction in hypertrophied hearts-Role of myocyte cytoskeleton-
- Principal Investigator
  
  TSUTSUI Hiroyuki
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  KYUSHU UNIVERSITY FACULTY OF MEDICINE
心肥大形成における細胞骨格の役割についての細胞・分子生物学的研究
- Principal Investigator
  
  TAKESHITA Akira
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyushu University
肥大から収縮不全への進展機構の単離心筋細胞レベルでの解明
- Principal Investigator
  
  浦部由利
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Kyushu University
ROLE OF MICROVASCULAR DISORDERS IN THE PATHOGENESIS OF MYOCARDIAL ISCHEMIA
- Principal Investigator
  
  TAKESHITA Akira
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  KYUSHU UNIVERSITY FACULTY OF MEDICINE
Analysis of homeostatic responses to stressful environments using molecular techniques.
- Principal Investigator
  
  HORI Tetsuro
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Environmental physiology (including Physical medicine and Nutritional physiology)
- Research Institution
  KYUSHU UNIVERSITY
心臓発生過程および成熟心臓機能における線維芽細胞成長因子の役割の解明Principal Investigator
- Principal Investigator
  
  上野光
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Kyushu University
Role of Inflammatory Cytokines in the Development and Progression of Ischemic Heart Diseases-Experimental and Clinical Studies-
- Principal Investigator
  
  SHIMOKAWA Hiroaki
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Kyushu University

All 2005 2004 2003

All Journal Article

[Journal Article] Local expression of platelet-activating factor-acetylhydrolase reduces accumulation of oxideized lipoproteins, and inhibits inflammation, shear stress-induced thrombosis,and neointima formation in balloon-injured carotid arteries in non-hyperlipidemic rabbits.2005
- Author(s)
  Arakawa H, Qian J-Y, Baatar D, Karasawa K, Asada Y, Sasaguri Y, Miller ER, Witztum JL, Ueno H
- Journal Title
  
  Circulation (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390255
[Journal Article] CaMK II activates ASK1 and NF-kB to induce cardiomyocyte hypertrophy.2005
- Author(s)
  Kashiwase K, Higuchi Y, Hirotani S, Yamaguchi O, Hikoso S, Takeda T, Watanabe T, Taniike M, Nakai A, Tsujimoto I, Matsumura Y, Ueno H, Nishida K, Hori M, Otsu K
- Journal Title
  
  Biochemical and Biophysical Research Communications 327
  
  Pages: 136-142
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390255
[Journal Article] Suppression of macrophage infiltration inhibits activation of hepatic stellate cells and liver fibrogenesis in rats.2005
- Author(s)
  Imamura M, Ogawa T, Sasaguri Y, Chayama K, Ueno H
- Journal Title
  
  Gasteroenterology 128
  
  Pages: 138-146
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390255
[Journal Article] Transduction of soluble Flt-1 gene to peritoneal mesothelial cells can effectively suppress peritoneal metastasis of gastric cancer.2004
- Author(s)
  Sako A, Kitayama J, Kojima H, Ueno H, Uchida H, Hamada H, Nagawa H
- Journal Title
  
  Cancer Res. 64
  
  Pages: 3624-3628
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390255
[Journal Article] Mechanical stretch induces TGF-beta synthesis in hepatic stellate cells.2004
- Author(s)
  Sakata R, Ueno T, Nakamura T, Ueno H, Sata M
- Journal Title
  
  Eur J Clin Invest. 34
  
  Pages: 129-136
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390255
[Journal Article] Pitavastatin enhances the anti-fibrogenesis effects of candesartan, an angiotensin receptor blocker, on CCl4-induced liver fibrosis in rats.2004
- Author(s)
  Nie L, Imamura M, Itoh H, Ueno H
- Journal Title
  
  J UOEH. 26
  
  Pages: 165-177
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390255
[Journal Article] Inhibition of transforming growth factor β decreases pancreatic fibrosis and protects the pancreas against chronic injury in mice.2004
- Author(s)
  Nagashio Y, Ueno H, Imamura M, Asaumi H, Watanabe S, Yamaguchi T, Taguchi M, Tashiro M, Otsuki M
- Journal Title
  
  Lab Invest. 84
  
  Pages: 1610-1618
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390255
[Journal Article] TGF-beta is not involved in early phase growth inhibition of keratinocytes by 1alpha, 25(OH)(2)vitamin D(3).2004
- Author(s)
  Shirakata, Ueno H, Hanakawa Y, Kameda K, Yamasaki K, Tokumaru S, Yahata Y, Tohyama M, Sayama K, Hashimoto K
- Journal Title
  
  J Dermatol Sci. 36
  
  Pages: 41-50
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390255
[Journal Article] Histopathological amelioration of fibroproliferative change in rat irradiated lung using soluble transforming growth factor-beta (TGF-6) receptor mediated by adenoviral vector.2004
- Author(s)
  Nishioka A, Ogawa Y, Mima T, Jin Y-J, Sonobe H, Kariya S, Kubota K, Yoshida S, Ueno H
- Journal Title
  
  Int J Radiat Oncol Biol Phys. 58
  
  Pages: 1235-1241
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390255
[Journal Article] Blockade of TGF-β action ameliorates renal dysfunction and histological progress in Anti-GBM nephritis.2003
- Author(s)
  Zhou A, Ueno H, Shimomura M, Tanaka R, Shirakawa T, Nakamura H, Matsuo M, Iijima K
- Journal Title
  
  Kindey Int. 64
  
  Pages: 92-101
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390255
[Journal Article] Catheter-based adenovirus-mediated local intravascular gene delivery of a soluble TGF-β bb b type II receptor using an Infiltrator in porcine coronary arteries : efficacy and complications.2003
- Author(s)
  Chung I-M, Ueno H, Pak Kim, Kim J-W, Choi D-H, Shin J G, Yang W-I, Jang SY
- Journal Title
  
  Exp Mol Med. 34
  
  Pages: 299-307
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390255
[Journal Article] Adenovirus-mediated expression of dominant negative FGF receptor-1 in thyroid cells blocks FGF effects and reduces goitrogenesis in mice.2003
- Author(s)
  Davies EL, Ramsden JD, Cocks H, Searle PF, Watkinson JC, Ueno H, Logan A, Franklyn JA, Mautner V, Eggo MC
- Journal Title
  
  J Clin Endocrinol Metab. 88
  
  Pages: 4472-4448
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390255
[Journal Article] The small GTP-binding protein Rac1 induces cardiac myocyte hypertrophy through the activation of apoptosis signal-regulation kinase 1 and nuclear factor-κB.2003
- Author(s)
  Higuchi Y, Otsu K, Nishida K, Hirotani S, Nakayama H, Yamaguchi O, Hikoso S, Kashiwase K, Takeda T, Watanabe T, Mano T, Matsumura Y, Ueno H, Tada M, Hori M
- Journal Title
  
  J Biol Chem. 278
  
  Pages: 20770-20777
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390255
[Journal Article] Synergistic effect of sphingosine 1-phosphage on thrombin-induced tissue factor expression in endothelial cells.2003
- Author(s)
  Takeya H, Gabazza EC, Aoki S, Ueno H, Suzuki K
- Journal Title
  
  Blood 102
  
  Pages: 1693-1700
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390255
[Journal Article] Inhibitory effect of a soluble transforming growth factor beta type II receptor on the activation of rat hepatic stellate cells in primary culture.2003
- Author(s)
  Cui X, Shimizu I, Lu G, Itonaga M, Inoue H, Shono M, Tamaki K, Fukuno H, Ueno H, Ito S
- Journal Title
  
  J Hepatol. 39
  
  Pages: 731-737
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390255
[Journal Article] Transfer of IκBα gene increase the sensitivity of paclitaxel mediated with caspase 3 activation in human lung cancer cell.2003
- Author(s)
  Osaki S, Nakanishi Y, Takayama K, Pei X-Y, Ueno H, Hara N
- Journal Title
  
  J Exp Clin Cancer Res. 22
  
  Pages: 69-75
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390255

1. TAKESHITA Akira (30038814)

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2. TSUTSUI Hiroyuki (70264017)

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3. SHIMOKAWA Hiroaki (00235681)

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4. 中西洋一 (20172356)

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6. SASAGURI Yasuyuki (60140646)

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7. SUEISHI Katsuo (70108710)

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8. EGASHIRA Kensuke (60260379)

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17. TAKE Sachiko (80253425)

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18. TAKAKI Atsushi (30243934)

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19. KATAFUCHI Toshihiko (80177401)

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20. AOU Shuji (40150908)

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21. SETOGUCHI Yasuhiro (90206649)

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22. MORI Eizou (90146598)

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23. ICHIKI Toshihiro (80311843)

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24. UTSUMI Hideo (20101694)

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26. MATSUDA Takehisa (60142189)

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27. MASUDA Munetaka (10190365)

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28. TOMITA Yukihiro (90180174)

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45. 尾本和也

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UENO Hikaru 上野 光

Research Projects

Research Products

Co-Researchers

細胞外マトリクス制御分子群を用いた抗浸潤・転移療法の開発Principal Investigator

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ハイブリッド型リボザイムライブラリを用いた新規がん転移関連遺伝子の同定と機能解析Principal Investigator

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Gene transfer-mediated molecular analysis of pathophysiology in injured arteries and development of local anti-inflammatory and anti-thrombotic therapyPrincipal Investigator

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血管新生抑制分子・転移抑制分子を用いた癌の遺伝子治療法の開発Principal Investigator

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組織特異性を有する遺伝子導入ベクター(改変型アデノウイルス)の開発Principal Investigator

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血管新生抑制分子・転移抑制分子を用いた固形癌の遺伝子治療法の開発Principal Investigator

Principal Investigator

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Review Section

Research Institution

Gene transfer-mediated molecular analysis of pathophysiology in injured arteriesPrincipal Investigator

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Principal Investigator

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多角的戦略に基づく組換えアデノウィルスによる固形癌の遺伝子治療法の開発Principal Investigator

Principal Investigator

Project Period (FY)

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Research Institution

傷害血管壁再構築におけるTGF-βおよび細胞外マトリクスの動的役割 組換えアデノウィルスを利用した血管壁遺伝子導入による分子細胞生物学的解析Principal Investigator

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UENO Hikaru 上野光

傷害血管壁再構築におけるTGF-βおよび細胞外マトリクスの動的役割組換えアデノウィルスを利用した血管壁遺伝子導入による分子細胞生物学的解析Principal Investigator