Nakayama Fumiaki 中山文明

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NAKAYAMA Fumiaki 中山文明

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Researcher Number	50277323
Affiliation (Current)	2022: 国立研究開発法人量子科学技術研究開発機構, 放射線医学研究所放射線規制科学研究部, グループリーダー
Affiliation (based on the past Project Information) *help	2021: 国立研究開発法人量子科学技術研究開発機構, 放射線医学研究所放射線規制科学研究部, グループリーダー 2018 – 2020: 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所放射線障害治療研究部, グループリーダー(定常) 2017: 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所放射線障害治療研究部, チームリーダー(定常) 2014: 独立行政法人放射線医学総合研究所, 重粒子医科学センター, チームリーダー 2010 – 2013: 独立行政法人放射線医学総合研究所, 重粒子医科学センター, 主任研究員 2006 – 2007: 独立行政法人放射線医学総合研究所, 緊急被ばく医療研究センター, 主任研究員
Review Section/Research Field	Principal Investigator Radiation science / Risk sciences of radiation/Chemicals / Basic Section 52040:Radiological sciences-related Except Principal Investigator Radiation science / Basic Section 52040:Radiological sciences-related
Keywords	Principal Investigator 放射線 / 防護剤 / 再生医学 / 蛋白質 / 生体分子 / 放射線障害 / 増殖因子 / 治療薬 / 再生医療 / 細胞内移行 … More / 血管肉腫 / 放射線治療 / 血管育種 / 転移 / 粒子線 / FGF / 組織幹細胞 … More Except Principal Investigator 放射線障害 / TNFα / ノックアウト / radiation / TNF_α / R / O mouse / survival / 放射線防護 / 線維芽細胞増殖因子 Less

組織修復幹細胞による放射線障害治療研究Principal Investigator
- Principal Investigator
  
  中山文明
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  National Institutes for Quantum Science and Technology
放射線障害防護分子としてのFGFの機能解析
- Principal Investigator
  
  川野光子
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  National Institutes for Quantum Science and Technology
Basic research on radiotherapy of angiosarcomaPrincipal Investigator
- Principal Investigator
  
  Nakayama Fumiaki
- Project Period (FY)
  2017 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  National Institutes for Quantum Science and Technology
Research on new mechanism for radioprotective effect of FGF12Principal Investigator
- Principal Investigator
  
  NAKAYAMA Fumiaki
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  National Institute of Radiological Sciences
FGF12による放射線障害の予防治療研究Principal Investigator
- Principal Investigator
  
  中山文明
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Risk sciences of radiation/Chemicals
- Research Institution
  National Institute of Radiological Sciences
The role of TNF α in mice exposed to radiation
- Principal Investigator
  
  MAKOTO Akashi
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  National Institute of Radiological Sciences

All 2018 2014 2013 2012 2011 2010 2007 2006 Other

All Journal Article Presentation Patent

[Journal Article] Cellular Internalization of Fibroblast Growth Factor-12 Exerts Radioprotective Effects on Intestinal Radiation Damage Independently of FGFR Signaling2014
- Author(s)
  F.Nakayama, S.Umeda, T.Yasuda, M.Fujita, M.Asada, V.Meineke, T.Imamura, T.Imai.
- Journal Title
  
  International Journal of Radiation Oncology Biology Physics
  
  Volume: 88 Pages: 377-384
- DOI
  10.1016/j.ijrobp.2013.10.035
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591856
[Journal Article] Upregulated expression of FGF13/FHF2 mediates resistance to platinum drugs in cervical cancer cells.2013
- Author(s)
  T.Okada, K.Murata, R.Hirose, C.Matsuda, T.Komatsu, M.Ikekita, M.Nakawatari, F.Nakayama, M.Wakatsuki, T.Ohno, S.Kato, T.Imai, T.Imamura
- Journal Title
  
  Scientific Reports
  
  Volume: 3 Pages: 2899-2899
- DOI
  10.1038/srep02899
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591856
[Journal Article] Sulfation of keratan sulfate proteoglycan reduces radiation-induced apoptosis in human Burkitt's lymphoma cell lines2013
- Author(s)
  Nakayama, F., Umeda, S., Ichimiya, T., Kamiyama, S., Hazawa, M., Yasuda, T., Nishihara, S., Imai, T
- Journal Title
  
  FEBS Letters
  
  Volume: 587 Pages: 231-237
- DOI
  10.1016/j.febslet.2012.12.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23651050, KAKENHI-PROJECT-24591856
[Journal Article] Structural stability of human fibroblast growth factor-1 is essential for protective effects against radiation-induced intestinal damage.2013
- Author(s)
  Nakayama, F., Umeda, S., Yasuda, T., Asada, M., Motomura, K., Suzuki, M., Zakrzewska, M., Imamura, T., and Imai, T
- Journal Title
  
  International Journal of Radiation Oncology Biology Physics
  
  Volume: 85 Pages: 477-483
- DOI
  10.1016/j.ijrobp.2012.04.042
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23651050, KAKENHI-PROJECT-24591856
[Journal Article] Fibroblast Growth Factor-12 (FGF12) Translocation into Intestinal Epithelial Cells Is Dependent on a Novel Cell-penetrating Peptide Domain2011
- Author(s)
  Fumiaki Nakayama, Takeshi Yasuda, Sachiko Umeda, Masahiro Asada, Toru Imamura, Viktor Meineke, Makoto Akashi
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 286 Pages: 25823-25834
- DOI
  10.1074/jbc.m110.198267
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22510065, KAKENHI-PROJECT-23651050
[Journal Article] Radiation Damage in the Human Body - Acute Radiation Syndrome and multiple organ failure2006
- Author(s)
  Makoto Akashi, Taiji Tamura, takako Tominaga, Kenichi Abe, Misao Hachiya, Fumiaki Nakayama
- Journal Title
  
  Nuclear Engineering and technology 38(3)
  
  Pages: 231-238
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591399
[Journal Article] Radiation Damage in the Human Body-Acute Radiation Syndrome and multiple organ failure2006
- Author(s)
  Makoto Akashi, Taiji Tamura, Takako Tominaga, Kenichi Abe, Misato Hachiya, fumiaki Nakayama
- Journal Title
  
  Nuclear Engineering and Technology 38・3
  
  Pages: 231-238
- Data Source
  KAKENHI-PROJECT-18591399
[Journal Article] Radiation Damage in the Human Body-Acute Radiation Syndrome and multiple organ failure2006
- Author(s)
  Makoto Akashi, Taiji Tamura, Takako Tominaga, Kenichi Abe, Misao Hachiya, Fumiaki Nakayama
- Journal Title
  
  Nuclear Engineering and Technology Vol.38,No.3
  
  Pages: 231-238
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591399
[Patent] 細胞膜透過性の線維芽細胞増殖因子の医療用途2013
- Inventor(s)
  中山文明、梅田禎子、安田武嗣、藤田真由美、今井高志
- Industrial Property Rights Holder
  放射線医学総合研究所
- Industrial Property Rights Type
  特許
- Filing Date
  2013-11-11
- Overseas
- Data Source
  KAKENHI-PROJECT-24591856
[Patent] 細胞膜透過性の線維芽細胞増殖因子の医療用途2012
- Inventor(s)
  中山　文明、梅田　禎子、安田　武嗣、藤田　真由美、今井　高志
- Industrial Property Rights Holder
  放射線医学総合研究所
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2012-259816
- Filing Date
  2012-11-28
- Data Source
  KAKENHI-PROJECT-24591856
[Presentation] 高活性型FGF1-FGF受容体1シグナルは血管肉腫細胞の増殖・転移能を抑制する2018
- Author(s)
  三浦太一、川野光子、藤田真由美、安田武嗣、西原祥子、増澤幹男、中山文明
- Organizer
  日本放射線影響学会61回大会
- Data Source
  KAKENHI-PROJECT-17K10498
[Presentation] FGF1の構造安定化による放射線障害小腸の再生について2013
- Author(s)
  中山　文明
- Organizer
  第１１回日本再生医療学会総会
- Place of Presentation
  パシフィコ横浜（神奈川県）
- Data Source
  KAKENHI-PROJECT-24591856
[Presentation] FGF1の細胞内移行促進による放射線障害小腸の再生効果について2013
- Author(s)
  中山　文明
- Organizer
  第12回日本再生医療学会総会
- Place of Presentation
  パシフィコ横浜（神奈川県）
- Data Source
  KAKENHI-PROJECT-24591856
[Presentation] FGF chimeric growth factor (FGFC) promoted hair regeneration after radiation damage2012
- Author(s)
  Fumiaki Nakayama
- Organizer
  The 37th Annual Meeting of the Japanese Society for Investigative Dermatology
- Place of Presentation
  パシフィックホテル沖縄(沖縄県）
- Data Source
  KAKENHI-PROJECT-24591856
[Presentation] Stabilization of fibroblast growth FACTOR-1 improved radiation-induced hair follicle dystrophy with the maintenance of hair follicle stem cells2012
- Author(s)
  Fumiaki Nakayama
- Organizer
  ISSCR2012
- Place of Presentation
  パシフィコ横浜（神奈川県）
- Data Source
  KAKENHI-PROJECT-24591856
[Presentation] 放射線小腸障害の予防・治療効果に対するFGF1構造安定化の評価2012
- Author(s)
  中山　文明
- Organizer
  日本放射線影響学会第55回大会
- Place of Presentation
  東北大学川内北キャンパス(宮城県)
- Data Source
  KAKENHI-PROJECT-24591856
[Presentation] 膜透過ペプチド融合FGF1の放射線防護効果について2012
- Author(s)
  中山　文明
- Organizer
  The 35th Annual Meeting of the Molecular Biology Society of Japan
- Place of Presentation
  福岡国際会議場(福岡県)
- Data Source
  KAKENHI-PROJECT-24591856
[Presentation] FGF12における膜透過ペプチドドメインの同定2011
- Author(s)
  中山文明、安田武嗣、梅田禎子、浅田眞弘、今村亨、明石真言
- Organizer
  第10回日本再生医療学会総会
- Place of Presentation
  京王プラザホテル(東京都)
- Year and Date
  2011-03-01
- Data Source
  KAKENHI-PROJECT-22510065
[Presentation] FGF12の小腸に対する放射線防護効果について2011
- Author(s)
  中山文明、梅田禎子、安田武嗣、浅田眞弘、鈴木理、今村亨、今井高志
- Organizer
  日本放射線影響学会第54回大会
- Place of Presentation
  神戸商工会議所会館(兵庫県)
- Year and Date
  2011-11-18
- Data Source
  KAKENHI-PROJECT-22510065
[Presentation] Mutant of Human Fibroblast Growth Factor-1 (Q40P/S47I/H93G) Has Strong Radioprotective Effects in Mice2011
- Author(s)
  Fumiaki Nakayama, Sachiko Umeda, Masahiro Asada, Masashi Suzuki, Malgorzata Zakrzewska, Toru Imamura, Takashi Imai
- Organizer
  14th International Congress of Radiation Research (ICRR'2011)
- Place of Presentation
  The Palace of Culture and Science (Warsaw, POLAND)
- Year and Date
  2011-08-29
- Data Source
  KAKENHI-PROJECT-22510065
[Presentation] リンパ腫細胞におけるPAPST1によるケラタン硫酸の硫酸化増加と放射線抵抗性について2011
- Author(s)
  中山文明、梅田禎子、一宮智美、神山伸、西原祥子、今井高志
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  国立京都国際会館(京都府)
- Year and Date
  2011-09-22
- Data Source
  KAKENHI-PROJECT-22510065
[Presentation] 放射線障害における毛包幹細胞の検討2010
- Author(s)
  中山文明、梅田禎子、木村美穂、今村亨、明石真言
- Organizer
  第35回日本研究皮膚科学会総会・学術大会
- Place of Presentation
  和歌山県民文化会館(和歌山県)
- Year and Date
  2010-12-03
- Data Source
  KAKENHI-PROJECT-22510065
[Presentation] FGF12における膜透過ペプチドドメインの同定2010
- Author(s)
  中山文明、安田武嗣、梅田禎子、浅田眞弘、今村亨、明石真言
- Organizer
  BMB2010(第33回日本分子生物学会年会・第83回日本生化学会大会合同大会)
- Place of Presentation
  神戸国際会議場(兵庫県)
- Year and Date
  2010-12-07
- Data Source
  KAKENHI-PROJECT-22510065
[Presentation] Evaluation of a FGF1/FGF2 chimeric protein for its heparin -dependence, receptor specificity and protective potential against radiation-induced damage2007
- Author(s)
  Kaori Motomura, Akiko Hagiwara, Masashi Suzuki, Miho Kimura, Junko Oki, Fumiaki Nakayama Makoto Akashi, Toru Imamura
- Organizer
  The Japan Radiation Research Society
- Place of Presentation
  Chiba
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591399
[Presentation] ヒト皮膚角化細胞における電離放射線によるヘパラン硫酸プロテオグリカンの発現制御について2007
- Author(s)
  中山文明、萩原亜紀子、須藤誠、明石真言
- Organizer
  日本研究皮膚科学会第32回次学術大会・総会
- Place of Presentation
  パシフィコ横浜
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591399
[Presentation] FGF12のヒト肥満細胞株HMC-1における放射線誘導性アポトーシス抑制効果について2007
- Author(s)
  中山文明、ミュラーカースティン、萩原亜紀子、リディローランド、明石真言、マイネッケビクトール
- Organizer
  日本放射線影響学会第50回大会
- Place of Presentation
  幕張メッセ国際会議場
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591399
[Presentation] The Regulation of Heparan Sulfate Proteoglycan By Ionizing Radiation in Human Keratinocytes2007
- Author(s)
  Fumiaki Nakayama, Akiko Hagiwara, Makoto Sudo, Makoto Akashi
- Organizer
  The Japanese Society for Investigative Dermatology
- Place of Presentation
  Yokohama
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591399
[Presentation] FGFl protects murine jejunum against radiation-induced Injiries more effectively than FGF7 and FGF102007
- Author(s)
  Akiko Hagiwara, Fumiaki Nakayama, Kaori Motomura, Masahiro Asada, Masashi Suzuki, Toru Imamura, Makoto Akashi
- Organizer
  The Japana Radiation Research Society
- Place of Presentation
  Chiba
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591399
[Presentation] Anti-oxidative enzyme catalase controls proliferation of HaCaT cells through the regulation of hepparan sulfate 2-O-sulfotransferase2007
- Author(s)
  Fumiaki Nakayama, Akiko Hagiwara, Makoto Akashi
- Organizer
  European Society for Dermatological esearch, University
- Place of Presentation
  Zurich-Irchel
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591399
[Presentation] FGF12のヒト肥満細胞株HMC-1における放射線誘導性アポトーシス抑制効果について2007
- Author(s)
  中山文明、ミュラーカースティン萩原亜紀子、リディローランド、明石真言、マイネッケビクトール
- Organizer
  日本放射線影響学会第50回大会
- Place of Presentation
  幕張メッセ国際会議場
- Data Source
  KAKENHI-PROJECT-18591399
[Presentation] FGF1のマウス空腸の放射線障害における防護効果の優位性について2007
- Author(s)
  萩原亜紀子、中山文明、本村香織、浅田眞弘、鈴木理、今村亨、明石真言
- Organizer
  日本放射線影響学会第50回大会
- Place of Presentation
  日本放射線影響学会第50回大会
- Data Source
  KAKENHI-PROJECT-18591399
[Presentation] 放射線障害の予防治療薬候補としてのFGF1/FGF-2キメラタンパク質のヘパリン依存性とFGF受容体特異性の評価2007
- Author(s)
  本村香織、萩原亜紀子、鈴木理、木村美穂、隠岐潤子、中山文明、明石真言、今村亨
- Organizer
  日本放射線影響学会第50回大会
- Place of Presentation
  幕張メッセ国際会議場
- Data Source
  KAKENHI-PROJECT-18591399
[Presentation] ヒト皮膚角化細胞における電離放射線によるヘパラン硫酸プロテオグリカンの発現制御について2007
- Author(s)
  中山文明、萩原亜紀子、須藤誠、明石真言
- Organizer
  日本研究皮膚科学会第32回年次学術大会・総会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-18591399
[Presentation] Anti-oxidative enzyme catalase controls proliferation of HaCaT cells through the regulation of heparan sulfate 2-0-sulfotransferase2007
- Author(s)
  中山文明、萩原亜紀子、明石真言
- Organizer
  ヨーロッパ研究皮膚科学会
- Place of Presentation
  University Zurich-lrchel
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591399
[Presentation] FGF12 in hibits ionizing radiation-induced apoptosis in the human leukemic mast cell line HMC-12007
- Author(s)
  Fumiaki Nakayama, Kerstin Muller, Akiko Hagiwara, Roland Ridi, Makoto Akashi, Viktor Meineke
- Organizer
  The Japan Radiation Research Society
- Place of Presentation
  Chiba
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591399
[Presentation] FGF1のマウス空腸の放射線障害における防護効果の優位性について2007
- Author(s)
  萩原亜紀子、中山文明、本村香織、浅田眞弘、鈴木理、今村亨、明石真言
- Organizer
  日本放射線影響学会第50回大会
- Place of Presentation
  幕張メッセ国際会議場
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591399
[Presentation] 放射線障害の予防治療薬候補としてのFGF1/FGF-2キメラタンパク質のヘパリン依存性とFGF受容体特異性の評価2007
- Author(s)
  本村香織、萩原亜紀子、鈴木理、木村美穂、隠岐潤子、中山文明、明石真言、今村亨
- Organizer
  日本放射線影響学会第50回大会
- Place of Presentation
  幕張メッセ国際会議場
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591399
[Presentation] 安定化FGF1による放射線脱毛の治療効果について
- Author(s)
  中山文明、梅田禎子、安田武嗣、今村亨、今井高志
- Organizer
  日本放射線影響学会第57回大会
- Place of Presentation
  かごしま県民交流センター
- Year and Date
  2014-10-01 – 2014-10-02
- Data Source
  KAKENHI-PROJECT-24591856
[Presentation] FGF12の細胞内移行による放射線防護効果について
- Author(s)
  中山文明, 梅田禎子, 安田武嗣, 浅田眞弘, 今村亨, 今井高志
- Organizer
  日本放射線影響学会　第56回大会
- Place of Presentation
  ホテルクラウンパレス青森
- Data Source
  KAKENHI-PROJECT-24591856
[Presentation] FGF12のFGFR非依存性な細胞内移行による小腸放射線障害防護効果
- Author(s)
  中山文明, 梅田禎子, 安田武嗣, 浅田眞弘, 今村亨, 今井高志
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸ポートピアホテル
- Data Source
  KAKENHI-PROJECT-24591856

1. IMAI Takashi (50183009)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
2. MAKOTO Akashi (10222514)

# of Collaborated Projects: 1 results

# of Collaborated Products: 17 results
3. HACHIYA Misao (00198756)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
4. TOMINAGA Takako (50415436)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
5. YASUDDA Takeshi (60332269)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
6. SUDO Makoto (40415427)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
7. 川野光子 (90422203)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. UMEDA Sachiko

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results

Nakayama Fumiaki 中山 文明

NAKAYAMA Fumiaki 中山 文明

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組織修復幹細胞による放射線障害治療研究Principal Investigator

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放射線障害防護分子としてのFGFの機能解析

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Basic research on radiotherapy of angiosarcomaPrincipal Investigator

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Research on new mechanism for radioprotective effect of FGF12Principal Investigator

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FGF12による放射線障害の予防治療研究Principal Investigator

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The role of TNF α in mice exposed to radiation

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[Journal Article] Cellular Internalization of Fibroblast Growth Factor-12 Exerts Radioprotective Effects on Intestinal Radiation Damage Independently of FGFR Signaling2014

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[Journal Article] Upregulated expression of FGF13/FHF2 mediates resistance to platinum drugs in cervical cancer cells.2013

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[Journal Article] Sulfation of keratan sulfate proteoglycan reduces radiation-induced apoptosis in human Burkitt's lymphoma cell lines2013

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[Journal Article] Structural stability of human fibroblast growth factor-1 is essential for protective effects against radiation-induced intestinal damage.2013

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[Journal Article] Fibroblast Growth Factor-12 (FGF12) Translocation into Intestinal Epithelial Cells Is Dependent on a Novel Cell-penetrating Peptide Domain2011

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[Journal Article] Radiation Damage in the Human Body - Acute Radiation Syndrome and multiple organ failure2006

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[Journal Article] Radiation Damage in the Human Body-Acute Radiation Syndrome and multiple organ failure2006

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[Journal Article] Radiation Damage in the Human Body-Acute Radiation Syndrome and multiple organ failure2006

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Nakayama Fumiaki 中山文明

NAKAYAMA Fumiaki 中山文明