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YAMAGUCHI Yoshihide  山口 宜秀

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… Alternative Names

山口 宜秀  ヤマグチ ヨシヒデ

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Researcher Number 50311832
Other IDs
Affiliation (Current) 2022: 東京薬科大学, 薬学部, 准教授
Affiliation (based on the past Project Information) *help 2019 – 2020: 東京薬科大学, 薬学部, 准教授
2014: 東京薬科大学, 薬学部, 准教授
2007: 東京薬科大学, 薬学部, 准教授
2001 – 2006: 東京薬科大学, 薬学部, 講師
2000: 高知医科大学, 医学部, 助手
Review Section/Research Field
Principal Investigator
Neuroscience in general / Basic Section 46010:Neuroscience-general-related
Except Principal Investigator
Biological Sciences / Neurochemistry/Neuropharmacology / Neurochemistry/Neuropharmacology
Keywords
Principal Investigator
性差 / 胎仔脳 / プロテオミクス / 2次元電気泳動 / エストロゲン受容体 / in situ hybridization / 翻訳リードスルー / ミエリン / 細胞接着 / リン酸化 … More / PKC / シャルコー・マリー・トゥース病 / 脳・神経 / リードスルー / 翻訳 … More
Except Principal Investigator
ミエリン / オリゴデンドロサイト / シュワン細胞 / ランビエ絞輪 / 電位依存性ナトリウムチャネル / スルファチド / 有髄神経 / 電位依存性カリウムチャネル / CGH / 固形腫瘍 / ペインティングプローブ / 染色体 / PCR / FISH / アストロサイト / 2次元電気泳動法 / リードスルー / 細胞接着 / リン酸化 / PKC / 神経科学 / 翻訳 / 脳・神経 / サルファチド / voltage-gated sodium channel / voltage-gated potassium channel / the nodes of Ranvier / myelin / myelinated nerve fiber / sulfatide / oligodendrocyte / shcwann cell Less
  • Research Projects

    (6 results)
  • Research Products

    (15 results)
  • Co-Researchers

    (10 People)
  •  Elucidation of the mechanism and physiological significance of translational readthrough in higher animals nervous systemPrincipal Investigator

    • Principal Investigator
      山口 宜秀
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 46010:Neuroscience-general-related
    • Research Institution
      Tokyo University of Pharmacy and Life Science
  •  Production mechanism and functional role of myelin protein produced by stop codon readthrough

    • Principal Investigator
      BABA Hiroko
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      Tokyo University of Pharmacy and Life Science
  •  グリアによる神経軸索上機能分子の発現および局在化調節機構の解明

    • Principal Investigator
      BABA Hiroko
    • Project Period (FY)
      2003 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Tokyo University of Pharmacy and Life Science
  •  Studies on molecular mechanisms of ion channel clustering at the nodes of Ranvier.

    • Principal Investigator
      BABA Hiroko
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      Tokyo University of Pharmacy and Life Science
  •  胎生期脳に発現する性特異的遺伝子の解析Principal Investigator

    • Principal Investigator
      山口 宜秀
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Neuroscience in general
    • Research Institution
      Tokyo University of Pharmacy and Life Science
  •  CGH法で検出された高度増幅遺伝子部位からの特異的ペインティングプローブの開発

    • Principal Investigator
      田口 尚弘
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      高知医科大学

All 2020 2019 2012 2007 Other

All Journal Article Presentation

  • [Journal Article] Upregulation of large myelin protein zero leads to Charcot-Marie-Tooth disease-like neuropathy in mice2020

    • Author(s)
      Otani Y., Ohno N., Cui J., Yamaguchi Y., Baba H.
    • Journal Title

      Communications Biology

      Volume: 3 Pages: 121-121

    • DOI

      10.1038/s42003-020-0854-z

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K06889, KAKENHI-PROJECT-19K16267, KAKENHI-PROJECT-16H06280
  • [Journal Article] L-MPZ, a novel isoform of myelin P0, is produced by stop codon readthrough.2012

    • Author(s)
      Yamaguchi Y, Hayashi A, Campagnoni CW, Kimura A, Inuzuka T, Baba H.
    • Journal Title

      J Biol Chem.

      Volume: 287 Pages: 17765-17776

    • DOI

      10.1074/jbc.m111.314468

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591239, KAKENHI-PROJECT-24500449, KAKENHI-PROJECT-24591256
  • [Journal Article] Two-dimensional electrophoresis with cationic detergents, a powerful tool for the proteomic analysis of myelin proteins. Part 1: technical aspects of electrophoresis.2007

    • Author(s)
      Yoshihide Yamaguchi, et. al.
    • Journal Title

      Journal of Neuroscience Research 86

      Pages: 755-765

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15082208
  • [Journal Article] Two-dimensional electrophoresis with cationic detergents: a powerful tool for the proteomic analysis of myelin proteins. Part 2: analytical aspects.2007

    • Author(s)
      Yoshihide Yamaguchi, et. al.
    • Journal Title

      Journal of Neuroscience Research 86

      Pages: 766-775

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15082208
  • [Presentation] 翻訳リードスルー産物である L-MPZは末梢神経系 におけるミエリン形成・維持に重要である2020

    • Author(s)
      後藤 雅裕,崔 晶晶,瀬戸口 潔,林 萌々花,平井 大之,大谷 嘉典,山口 宜秀,馬場 広子
    • Organizer
      第63回日本神経化学会大会
    • Data Source
      KAKENHI-PROJECT-19K06889
  • [Presentation] シャルコー・マリー・トゥース病モデルマウス:L-MPZマウスの病態進行の解析2020

    • Author(s)
      大谷 嘉典,崔 晶晶,山口 宜秀,藍郷 加奈子,原 綾香、坂 剛太、藤谷 昌司,馬場 広子
    • Organizer
      第63回日本神経化学会大会
    • Data Source
      KAKENHI-PROJECT-19K06889
  • [Presentation] Abnormalities of Peripheral Mmyelin Development in CharcotーMarieーTooth (CMT) Disease model, L-MPZ mouse.2019

    • Author(s)
      Y. Yamaguchi, Y. Otani, M. Takehara, T. Nakajima, T. Narazaki, J. Cui, H. Baba
    • Organizer
      2019 ISN-ASN Meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K06889
  • [Presentation] Excessive Production of L-MPZ, a Translational Readthrough Isoform of Myelin Protein Zero (P0, MPZ), Causes CharcotーMarieーTooth Disease (CMT)-like Phenotype.2019

    • Author(s)
      Y. Yamaguchi, Y. Otani, M. Takehara, T. Nakajima, T. Narazaki, J. Cui, H. Baba
    • Organizer
      The 14th Biennial ISN Satellite Meeting on Myelin Biology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K06889
  • [Presentation] Translational Readthrough Regulates Physiological Function in the Nervous System2019

    • Author(s)
      Y. Yamaguchi, Y. Otani, N. Ohno, J. Cui, H. Baba
    • Organizer
      第42回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-19K06889
  • [Presentation] シャルコー・マリー・トゥース病モデル L-MPZ マウスにおけるミエリン形成過程の解析2019

    • Author(s)
      山口 宜秀、大谷 嘉典、竹原 雅之、中島 鉄博、楢崎 琢朗、崔 晶晶、馬場  広子
    • Organizer
      NEURO 2019 第42回日本神経科学大会 第62回日本神経化学会大会 合同大会
    • Data Source
      KAKENHI-PROJECT-19K06889
  • [Presentation] Analysis of stop codon readthrough mechanism for production of L-MPZ2012

    • Author(s)
      Yoshihide Yamaguchi 他
    • Organizer
      The 11th Biennial Meeting of the Asian-Pacific Society for Neurochemistry/55th Annual Meeting of the Japanese Society for Neurochemistry
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-24500449
  • [Presentation] Analysis of high molecular weight myelin proteins using 16-BAC/SDS-PAGE2007

    • Author(s)
      山口宜秀, ら
    • Organizer
      ISN and ANS, 21st Biennial meeting
    • Place of Presentation
      Mexico
    • Year and Date
      2007-08-19
    • Data Source
      KAKENHI-PROJECT-15082208
  • [Presentation] 難治性白質変性疾患治療を目的とした脱髄および髄鞘再生メカニズムの解明2007

    • Author(s)
      山口 宜秀, ら
    • Organizer
      第1回次世代を担う若手医療薬科学シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2007-12-15
    • Data Source
      KAKENHI-PROJECT-15082208
  • [Presentation] Adhesion properties mediated by PKC-dependent phosphorylation are different between myelin P0 and its readthrough isoform L-MPZ

    • Author(s)
      Yoshihide Yamaguchi et al
    • Organizer
      12th Satellite Meeting on Myelin Biology 2015
    • Place of Presentation
      フィッツロイ島、オーストラリア
    • Year and Date
      2015-08-28 – 2015-08-31
    • Data Source
      KAKENHI-PROJECT-24500449
  • [Presentation] Adhesion properties mediated by PKC-dependent phosphorylation are different between myelin P0 and its readthrough isoform L-MPZ

    • Author(s)
      Yoshihide Yamaguchi et al
    • Organizer
      25th Meeting of the International Society for Neurochemistry
    • Place of Presentation
      ケアンズ、オーストラリア
    • Year and Date
      2015-08-23 – 2015-08-27
    • Data Source
      KAKENHI-PROJECT-24500449
  • 1.  BABA Hiroko (40271499)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 2.  HAYASHI Akiko (90232090)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 3.  田口 尚弘 (80127943)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  由利 和成 (10220534)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  石橋 智子 (50453808)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  NAKANISHI Hiroki
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  YANO Noriko
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  木村 暁夫
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 9.  犬塚 貴
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 10.  大谷 嘉典
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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