YAMAGUCHI Yoshihide 山口宜秀

… Alternative Names

山口宜秀ヤマグチヨシヒデ

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Researcher Number	50311832
Other IDs
Affiliation (Current)	2022: 東京薬科大学, 薬学部, 准教授
Affiliation (based on the past Project Information) *help	2019 – 2020: 東京薬科大学, 薬学部, 准教授 2014: 東京薬科大学, 薬学部, 准教授 2007: 東京薬科大学, 薬学部, 准教授 2001 – 2006: 東京薬科大学, 薬学部, 講師 2000: 高知医科大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Neuroscience in general / Basic Section 46010:Neuroscience-general-related Except Principal Investigator Biological Sciences / Neurochemistry/Neuropharmacology / Neurochemistry/Neuropharmacology
Keywords	Principal Investigator 性差 / 胎仔脳 / プロテオミクス / 2次元電気泳動 / エストロゲン受容体 / in situ hybridization / 翻訳リードスルー / ミエリン / 細胞接着 / リン酸化 … More / PKC / シャルコー・マリー・トゥース病 / 脳・神経 / リードスルー / 翻訳 … More Except Principal Investigator ミエリン / オリゴデンドロサイト / シュワン細胞 / ランビエ絞輪 / 電位依存性ナトリウムチャネル / スルファチド / 有髄神経 / 電位依存性カリウムチャネル / CGH / 固形腫瘍 / ペインティングプローブ / 染色体 / PCR / FISH / アストロサイト / 2次元電気泳動法 / リードスルー / 細胞接着 / リン酸化 / PKC / 神経科学 / 翻訳 / 脳・神経 / サルファチド / voltage-gated sodium channel / voltage-gated potassium channel / the nodes of Ranvier / myelin / myelinated nerve fiber / sulfatide / oligodendrocyte / shcwann cell Less

Elucidation of the mechanism and physiological significance of translational readthrough in higher animals nervous systemPrincipal Investigator
- Principal Investigator
  
  山口宜秀
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 46010:Neuroscience-general-related
- Research Institution
  Tokyo University of Pharmacy and Life Science
Production mechanism and functional role of myelin protein produced by stop codon readthrough
- Principal Investigator
  
  BABA Hiroko
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Tokyo University of Pharmacy and Life Science
グリアによる神経軸索上機能分子の発現および局在化調節機構の解明
- Principal Investigator
  
  BABA Hiroko
- Project Period (FY)
  2003 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo University of Pharmacy and Life Science
Studies on molecular mechanisms of ion channel clustering at the nodes of Ranvier.
- Principal Investigator
  
  BABA Hiroko
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Tokyo University of Pharmacy and Life Science
胎生期脳に発現する性特異的遺伝子の解析Principal Investigator
- Principal Investigator
  
  山口宜秀
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neuroscience in general
- Research Institution
  Tokyo University of Pharmacy and Life Science
CGH法で検出された高度増幅遺伝子部位からの特異的ペインティングプローブの開発
- Principal Investigator
  
  田口尚弘
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  高知医科大学

All 2020 2019 2012 2007 Other

All Journal Article Presentation

[Journal Article] Upregulation of large myelin protein zero leads to Charcot-Marie-Tooth disease-like neuropathy in mice2020
- Author(s)
  Otani Y., Ohno N., Cui J., Yamaguchi Y., Baba H.
- Journal Title
  
  Communications Biology
  
  Volume: 3 Pages: 121-121
- DOI
  10.1038/s42003-020-0854-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06889, KAKENHI-PROJECT-19K16267, KAKENHI-PROJECT-16H06280
[Journal Article] L-MPZ, a novel isoform of myelin P0, is produced by stop codon readthrough.2012
- Author(s)
  Yamaguchi Y, Hayashi A, Campagnoni CW, Kimura A, Inuzuka T, Baba H.
- Journal Title
  
  J Biol Chem.
  
  Volume: 287 Pages: 17765-17776
- DOI
  10.1074/jbc.m111.314468
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591239, KAKENHI-PROJECT-24500449, KAKENHI-PROJECT-24591256
[Journal Article] Two-dimensional electrophoresis with cationic detergents, a powerful tool for the proteomic analysis of myelin proteins. Part 1: technical aspects of electrophoresis.2007
- Author(s)
  Yoshihide Yamaguchi, et. al.
- Journal Title
  
  Journal of Neuroscience Research 86
  
  Pages: 755-765
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15082208
[Journal Article] Two-dimensional electrophoresis with cationic detergents: a powerful tool for the proteomic analysis of myelin proteins. Part 2: analytical aspects.2007
- Author(s)
  Yoshihide Yamaguchi, et. al.
- Journal Title
  
  Journal of Neuroscience Research 86
  
  Pages: 766-775
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15082208
[Presentation] 翻訳リードスルー産物である L-MPZは末梢神経系におけるミエリン形成・維持に重要である2020
- Author(s)
  後藤雅裕，崔晶晶，瀬戸口潔，林萌々花，平井大之，大谷嘉典，山口宜秀，馬場広子
- Organizer
  第63回日本神経化学会大会
- Data Source
  KAKENHI-PROJECT-19K06889
[Presentation] シャルコー・マリー・トゥース病モデルマウス:L-MPZマウスの病態進行の解析2020
- Author(s)
  大谷嘉典，崔晶晶，山口宜秀，藍郷加奈子，原綾香、坂剛太、藤谷昌司，馬場広子
- Organizer
  第63回日本神経化学会大会
- Data Source
  KAKENHI-PROJECT-19K06889
[Presentation] Abnormalities of Peripheral Mmyelin Development in CharcotーMarieーTooth (CMT) Disease model, L-MPZ mouse.2019
- Author(s)
  Y. Yamaguchi, Y. Otani, M. Takehara, T. Nakajima, T. Narazaki, J. Cui, H. Baba
- Organizer
  2019 ISN-ASN Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06889
[Presentation] Excessive Production of L-MPZ, a Translational Readthrough Isoform of Myelin Protein Zero (P0, MPZ), Causes CharcotーMarieーTooth Disease (CMT)-like Phenotype.2019
- Author(s)
  Y. Yamaguchi, Y. Otani, M. Takehara, T. Nakajima, T. Narazaki, J. Cui, H. Baba
- Organizer
  The 14th Biennial ISN Satellite Meeting on Myelin Biology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06889
[Presentation] Translational Readthrough Regulates Physiological Function in the Nervous System2019
- Author(s)
  Y. Yamaguchi, Y. Otani, N. Ohno, J. Cui, H. Baba
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K06889
[Presentation] シャルコー・マリー・トゥース病モデル L-MPZ マウスにおけるミエリン形成過程の解析2019
- Author(s)
  山口宜秀、大谷　嘉典、竹原　雅之、中島　鉄博、楢崎　琢朗、崔　晶晶、馬場　広子
- Organizer
  NEURO 2019 第42回日本神経科学大会　第62回日本神経化学会大会　合同大会
- Data Source
  KAKENHI-PROJECT-19K06889
[Presentation] Analysis of stop codon readthrough mechanism for production of L-MPZ2012
- Author(s)
  Yoshihide Yamaguchi 他
- Organizer
  The 11th Biennial Meeting of the Asian-Pacific Society for Neurochemistry/55th Annual Meeting of the Japanese Society for Neurochemistry
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-24500449
[Presentation] Analysis of high molecular weight myelin proteins using 16-BAC/SDS-PAGE2007
- Author(s)
  山口宜秀, ら
- Organizer
  ISN and ANS, 21st Biennial meeting
- Place of Presentation
  Mexico
- Year and Date
  2007-08-19
- Data Source
  KAKENHI-PROJECT-15082208
[Presentation] 難治性白質変性疾患治療を目的とした脱髄および髄鞘再生メカニズムの解明2007
- Author(s)
  山口宜秀, ら
- Organizer
  第1回次世代を担う若手医療薬科学シンポジウム
- Place of Presentation
  東京
- Year and Date
  2007-12-15
- Data Source
  KAKENHI-PROJECT-15082208
[Presentation] Adhesion properties mediated by PKC-dependent phosphorylation are different between myelin P0 and its readthrough isoform L-MPZ
- Author(s)
  Yoshihide Yamaguchi et al
- Organizer
  12th Satellite Meeting on Myelin Biology 2015
- Place of Presentation
  フィッツロイ島、オーストラリア
- Year and Date
  2015-08-28 – 2015-08-31
- Data Source
  KAKENHI-PROJECT-24500449
[Presentation] Adhesion properties mediated by PKC-dependent phosphorylation are different between myelin P0 and its readthrough isoform L-MPZ
- Author(s)
  Yoshihide Yamaguchi et al
- Organizer
  25th Meeting of the International Society for Neurochemistry
- Place of Presentation
  ケアンズ、オーストラリア
- Year and Date
  2015-08-23 – 2015-08-27
- Data Source
  KAKENHI-PROJECT-24500449

1. BABA Hiroko (40271499)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
2. HAYASHI Akiko (90232090)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. 田口尚弘 (80127943)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 由利和成 (10220534)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 石橋智子 (50453808)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. NAKANISHI Hiroki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. YANO Noriko

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 木村暁夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 犬塚貴

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 大谷嘉典

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

YAMAGUCHI Yoshihide 山口 宜秀

山口 宜秀 ヤマグチ ヨシヒデ

Research Projects

Research Products

Co-Researchers

Elucidation of the mechanism and physiological significance of translational readthrough in higher animals nervous systemPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Production mechanism and functional role of myelin protein produced by stop codon readthrough

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

グリアによる神経軸索上機能分子の発現および局在化調節機構の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Studies on molecular mechanisms of ion channel clustering at the nodes of Ranvier.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

胎生期脳に発現する性特異的遺伝子の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

CGH法で検出された高度増幅遺伝子部位からの特異的ペインティングプローブの開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Upregulation of large myelin protein zero leads to Charcot-Marie-Tooth disease-like neuropathy in mice2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] L-MPZ, a novel isoform of myelin P0, is produced by stop codon readthrough.2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Two-dimensional electrophoresis with cationic detergents, a powerful tool for the proteomic analysis of myelin proteins. Part 1: technical aspects of electrophoresis.2007

Author(s)

Journal Title

Data Source

[Journal Article] Two-dimensional electrophoresis with cationic detergents: a powerful tool for the proteomic analysis of myelin proteins. Part 2: analytical aspects.2007

Author(s)

Journal Title

Data Source

[Presentation] 翻訳リードスルー産物である L-MPZは末梢神経系 におけるミエリン形成・維持に重要である2020

Author(s)

Organizer

Data Source

[Presentation] シャルコー・マリー・トゥース病モデルマウス:L-MPZマウスの病態進行の解析2020

Author(s)

Organizer

Data Source

[Presentation] Abnormalities of Peripheral Mmyelin Development in CharcotーMarieーTooth (CMT) Disease model, L-MPZ mouse.2019

Author(s)

Organizer

Data Source

[Presentation] Excessive Production of L-MPZ, a Translational Readthrough Isoform of Myelin Protein Zero (P0, MPZ), Causes CharcotーMarieーTooth Disease (CMT)-like Phenotype.2019

Author(s)

Organizer

Data Source

[Presentation] Translational Readthrough Regulates Physiological Function in the Nervous System2019

Author(s)

Organizer

Data Source

[Presentation] シャルコー・マリー・トゥース病モデル L-MPZ マウスにおけるミエリン形成過程の解析2019

YAMAGUCHI Yoshihide 山口宜秀

山口宜秀ヤマグチヨシヒデ

[Presentation] 翻訳リードスルー産物である L-MPZは末梢神経系におけるミエリン形成・維持に重要である2020