KUME Hideaki 久米秀明

… Alternative Names

久米秀明クメヒデアキ

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Researcher Number	50322714
Affiliation (based on the past Project Information) *help	2017: 独立行政法人医薬基盤研究所, プロテオームリサーチプロジェクト, 研究員 2016: 国立研究開発法人医薬基盤・健康・栄養研究所, 医薬基盤研究所プロテオームリサーチプロジェクト, 協力研究員 2016: 国立研究開発法人医薬基盤・健康・栄養研究所, 医薬基盤研究所プロテオームリサーチプロジェクト, 特任研究員 2015: 国立研究開発法人医薬基盤・健康・栄養研究所, プロテオームリサーチプロジェクト, 特任研究員 2015: 国立研究開発法人医薬基盤・健康・栄養研究所, プロテオームリサーチプロジェクト, 研究員 … More 2015: 国立研究開発法人医薬基盤・健康・栄養研究所, ﾌﾟﾛﾃｵｰﾑﾘｻｰﾁﾌﾟﾛｼﾞｪｸﾄ, 研究員 2014: 国立研究開発法人医薬基盤・健康・栄養研究所, 創薬基盤的研究部, 特任研究員 2013 – 2014: 独立行政法人医薬基盤研究所, 創薬基盤研究部, 特任研究員 2012: 独立行政法人医薬基盤研究所, 創薬基盤研究部, 研究員 2011: 独立行政法人医薬基盤研究所, 創薬基盤研究部・プロテオームリサーチプロジェクト, 研究員 2010: 独立行政法人医薬基盤研究所, 創薬基盤研究部プロテオームリサーチプロジェクト, 研究員 2003 – 2004: 東北大学, 大学院・医学系研究科, 助手 Less
Review Section/Research Field	Principal Investigator Laboratory medicine Except Principal Investigator Urology / General medical chemistry / Tumor diagnostics / Biological Sciences
Keywords	Principal Investigator プロテオーム / 癌 / 細胞外小胞 / プロテオミクス / 腫瘍検査学 Except Principal Investigator 尿中バイオマーカー / エクソソーム / 前立腺癌 / channel crosstalk / junctional membrane complex … More / TRIC channel / ryanodine receptor / Calumin / junctophilin / endoplasmic reticulum / Ca^<2+> release / ジャンクロフィリン / Ca2+結合タンパク質 / Ca2+ストア / 筋収縮 / 興奮性細胞 / カルシウムストア / 後過分極 / 神経可塑性 / Ca2+依存性K+チャネル / K+チャネル / カウンターイオン / チャネル機能共役 / 結合膜構造 / カルミン / TRICチャネル / ジャンクトフィリン / リアノジン受容体 / 小胞体 / Ca2+放出 / バイオマーカー / 膜タンパク質 / 大腸癌 / 心筋 / 骨格筋 / E3ユビキチンリガーゼ / TRIMファミリー / RBCCファミリー / エンドソーム / 細胞膜 / 骨格筋細胞 / 心筋細胞 / カリウムチャネル / ミツグミン53 Less

細胞外小胞を標的とした腫瘍マーカー探索Principal Investigator
- Principal Investigator
  
  久米秀明
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Laboratory medicine
- Research Institution
  National Institutes of Biomedical Innovation, Health and Nutrition
The analysis of prostate cancer exosome and the development of new urinary biomarker
- Principal Investigator
  
  Fujita Kazutoshi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Osaka University
Comprehensive functional analysis of colorectal cancer biomarker candidates for the exploitation of diagnostic and therapeutic methods
- Principal Investigator
  
  Hara Yasuhiro
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor diagnostics
- Research Institution
  Osaka University
  National Institutes of Biomedical Innovation, Health and Nutrition
Proteomic analysis of membrane vesicles for elucidation of tumor communication mechanism and identification of tumor markersPrincipal Investigator
- Principal Investigator
  
  Kume Hideaki
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  National Institutes of Biomedical Innovation, Health and Nutrition
Membrane proteomic analysis of cancer tissue for identification of biomarkers for early diagnosisPrincipal Investigator
- Principal Investigator
  
  KUME Hideaki
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  独立行政法人医薬基盤研究所
ミツグミン53に関する研究
- Principal Investigator
  
  TAKESHIMA Hiroshi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
A study on the molecular hasis of intracellular Ca^<2+> stores
- Principal Investigator
  
  TAKESHIMA Hiroshi
- Project Period (FY)
  2003 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  General medical chemistry
- Research Institution
  Kyoto University
  Tohoku University

All 2017 2016 2015 2014 2013 2012 2011 2010 Other

All Journal Article Presentation Patent

[Journal Article] Proteomic analysis of urinary extracellular vesicles from high Gleason score prostate cancer.2017
- Author(s)
  Fujita K, Kume H, Matsuzaki K, Kawashima A, Ujike T, Nagahara A, Uemura M, Miyagawa Y, Tomonaga T, Nonomura N.
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1 Pages: 42961-42961
- DOI
  10.1038/srep42961
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K10588, KAKENHI-PROJECT-16K15626
[Journal Article] Discovery of colorectal cancer biomarker candidates by membrane proteomic analysisand subsequent verification using selected reaction monitoring and tissue microarrayanalysis2014
- Author(s)
  Kume H, Muraoka S, Kuga T, Adachi J, Narumi R, Watanabe S, Kuwano M, Kodera Y, Matsushita K, Fukuoka J, Masuda T, Ishihama Y, Matsubara H, Nomura F, Tomonaga T.
- Journal Title
  
  Mol Cell Proteomics.
  
  Volume: M113 Issue: 6 Pages: 37093-37093
- DOI
  10.1074/mcp.m113.037093
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-24116513, KAKENHI-PROJECT-24241062, KAKENHI-PROJECT-24659017, KAKENHI-PROJECT-24659622, KAKENHI-PROJECT-24790184, KAKENHI-PROJECT-25290054, KAKENHI-PROJECT-25460715, KAKENHI-PROJECT-26460081, KAKENHI-PROJECT-26640115, KAKENHI-PROJECT-26670614
[Journal Article] A novel mechanism of keratin cytoskeleton organization through casein kinase I alpha and FAM83H in colorectal cancer.2013
- Author(s)
  Kuga, T., Kume, H., Kawasaki, N., Sato, M., Adachi, J., Shiromizu, T., Hoshino, I., Nishimori, T., Matsubara, H., and Tomonaga T.
- Journal Title
  
  J Cell Sci
  
  Volume: 126 Pages: 4721-31
- DOI
  10.1242/jcs.129684
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659622, KAKENHI-PROJECT-24681009, KAKENHI-PROJECT-24790184, KAKENHI-PROJECT-25290054, KAKENHI-PROJECT-25460715, KAKENHI-PROJECT-25871241
[Journal Article] In-depth Membrane Proteomic Study of Breast Cancer Tissues for the Generation of a Chromosome-based Protein List2012
- Author(s)
  Muraoka S, Kume H, Adachi J, Shiromizu T, Watanabe S, Masuda T, Ishihama Y, Tomonaga T
- Journal Title
  
  J Proteome Res
  
  Volume: 12(1) Issue: 1 Pages: 208-13
- DOI
  10.1021/pr300824m
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590545, KAKENHI-PROJECT-23221006, KAKENHI-PROJECT-24681009, KAKENHI-PROJECT-24701015, KAKENHI-PUBLICLY-24116513
[Journal Article] Strategy for SRM-based verification of biomarker candidates discovered by iTRAQ method in limited breast cancer tissue samples.2012
- Author(s)
  Muraoka S, Kume H, Watanabe S, Adachi J, Kuwano M, Sato M, Kawasaki N, Kodera Y, Ishitobi M, Inaji H, Miyamoto Y, Kato K, Tomonaga T.
- Journal Title
  
  J Proteome Res.
  
  Volume: 11 Issue: 8 Pages: 4201-4210
- DOI
  10.1021/pr300322q
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390117, KAKENHI-PROJECT-22590545, KAKENHI-PROJECT-23501303, KAKENHI-PROJECT-23659305, KAKENHI-PROJECT-24701015
[Journal Article] A strategy for large-scale phosphoproteomics and SRM-based validation of human breast cancer tissue samples.2012
- Author(s)
  Narumi R, Murakami T, Kuga T, Adachi J, Shiromizu T, Muraoka S, Kume H, Kodera Y, Matsumoto M, Nakayama K, Miyamoto Y, Ishitobi M, Inaji H, Kato K, Tomonaga T.
- Journal Title
  
  J Proteome Res.
  
  Volume: 11 Issue: 11 Pages: 5311-5322
- DOI
  10.1021/pr3005474
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390117, KAKENHI-PROJECT-22590545, KAKENHI-PROJECT-23501303, KAKENHI-PROJECT-23659305, KAKENHI-PROJECT-24659622, KAKENHI-PROJECT-24790184, KAKENHI-PUBLICLY-24116518
[Patent] 大腸がんの判定方法2012
- Inventor(s)
  朝長毅、久米秀明
- Industrial Property Rights Holder
  独立行政法人医薬基盤研究所
- Industrial Property Rights Type
  特許
- Filing Date
  2012-12-27
- Data Source
  KAKENHI-PROJECT-22590545
[Patent] 大腸がんの判定方法2012
- Inventor(s)
  朝長毅、久米秀明
- Industrial Property Rights Holder
  独立行政法人医薬基盤研究所
- Filing Date
  2012-12-17
- Data Source
  KAKENHI-PROJECT-22590545
[Presentation] 尿中エクソソームを用いた高リスク前立腺癌バイオマーカーの開発2016
- Author(s)
  藤田和利、久米秀明、松崎恭介、河嶋厚成、氏家剛、永原啓、植村元秀、宮川康、朝長毅、野々村祝夫
- Organizer
  第32回前立腺シンポジウム
- Place of Presentation
  東京
- Year and Date
  2016-12-10
- Data Source
  KAKENHI-PROJECT-15K10588
[Presentation] Discovery of high-Gleason prostate cancer biomarker candidates from exosomes in urine after massage by proteomic analysis and subsequent verification using selected reaction monitoring2016
- Author(s)
  K. Fujita, H. Kume, K. Matsuzaki, A. Kawashima, T. Ujike, A. Nagahara, M. Uemura, T. Tomonaga, N. Nonomura
- Organizer
  European Journal of Cancer
- Place of Presentation
  Manchester, UK
- Year and Date
  2016-07-09
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10588
[Presentation] プロテオミクス解析による尿中前立腺癌由来エクソソームを用いたHigh risk前立腺癌新規バイオマーカーの開発2016
- Author(s)
  藤田和利、久米秀明、松崎恭介、河嶋厚成、氏家剛、永原啓、植村元秀、宮川康、朝長毅、野々村祝夫
- Organizer
  日本アンドロロジー学会総会
- Place of Presentation
  前橋市、群馬県
- Year and Date
  2016-06-23
- Data Source
  KAKENHI-PROJECT-15K10588
[Presentation] SRM/MRM法を用いた血中細胞外小胞画分における大腸癌バイオマーカー候補タンパク質の検証2015
- Author(s)
  久米秀明、小松亜紀、星野敢、松原久弘、朝長毅
- Organizer
  第11回日本プロテオーム学会
- Place of Presentation
  熊本
- Year and Date
  2015-07-23
- Data Source
  KAKENHI-PROJECT-25460715
[Presentation] 血中細胞外小胞のプロテオーム解析による大腸癌バイオマーカーの探索2015
- Author(s)
  久米秀明、星野敢、松原久弘、朝長毅
- Organizer
  第35回日本分子腫瘍マーカー研究会
- Place of Presentation
  名古屋
- Year and Date
  2015-10-07
- Data Source
  KAKENHI-PROJECT-25460715
[Presentation] 血中細胞外小胞のプロテオーム解析による大腸癌バイオマーカーの探索2015
- Author(s)
  久米秀明、星野敢、松原久弘、朝長毅
- Organizer
  第74回日本癌学会
- Place of Presentation
  名古屋
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-25460715
[Presentation] Discovery and subsequent validation of biomarkers for colorectal cancer by large-scale proteomic analysis and tissue microarray analysis2013
- Author(s)
  Kume H, Muraoka S, Hashimoto Y, Watanabe S, Masuda T, Ishihama Y, Fukuoka J, Kodera Y, Matsushita K, Matsubara H, Tomonaga T
- Organizer
  Human Proteome Organization (HUPO) 12th Annual World Congress
- Place of Presentation
  Yokohama
- Data Source
  KAKENHI-PROJECT-25460715
[Presentation] 大規模プロテオーム解析による大腸癌バイオマーカーの探索とその検証2012
- Author(s)
  久米秀明、村岡賢、小寺義男、松下一之、松原久裕、朝長毅
- Organizer
  第71回日本癌学会
- Place of Presentation
  札幌
- Year and Date
  2012-09-21
- Data Source
  KAKENHI-PROJECT-22590545
[Presentation] 大腸癌組織膜タンパク質の大規模プロテオーム解析によるバイオマーカー探索とその検証2012
- Author(s)
  久米秀明、渡邊史生、村岡賢、石濱泰、小寺義男、松下一之、松原久裕、朝長毅
- Organizer
  第10回日本プロテオーム学会
- Place of Presentation
  東京
- Year and Date
  2012-07-26
- Data Source
  KAKENHI-PROJECT-22590545
[Presentation] 大腸癌組織膜タンパク質の大規模プロテオーム解析によるバイオマーカー探索とその検証2012
- Author(s)
  久米秀明，渡邊史生，村岡賢，石濱泰，小寺義男，松下一之，松原久裕，朝長毅
- Organizer
  日本プロテオーム学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22590545
[Presentation] 大規模プロテオーム解析による大腸癌バイオマーカーの探索とその検証2012
- Author(s)
  久米秀明，村岡賢，小寺義男，松下一之，松原久裕，朝長毅
- Organizer
  日本癌学会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-22590545
[Presentation] 膜タンパク質の大規模プロテオーム解析による大腸癌バイオマーカーの探索とSRM法を用いた検証2011
- Author(s)
  久米秀明, 松原久裕, 小寺義男, 朝長毅
- Organizer
  第70回日本癌学会
- Place of Presentation
  名古屋
- Year and Date
  2011-10-04
- Data Source
  KAKENHI-PROJECT-22590545
[Presentation] 大腸癌バイオマーカーとなる膜タンパク質の大規模プロテオーム解析とSRMによる検証2011
- Author(s)
  久米秀明
- Organizer
  日本プロテオーム学会
- Place of Presentation
  新潟
- Year and Date
  2011-07-28
- Data Source
  KAKENHI-PROJECT-22590545
[Presentation] 大腸癌組織膜タンパク質の大規模プロテオーム解析によるバイオマーカー探索とSRM/MRM法を用いた定量法の確立および診断への応用2011
- Author(s)
  久米秀明, 鳴海良平, 渡邉史生,石濱泰, 松原久裕, 小寺義男, 福岡順也, 朝長毅
- Organizer
  第34回分子生物学会
- Place of Presentation
  横浜
- Year and Date
  2011-12-14
- Data Source
  KAKENHI-PROJECT-22590545
[Presentation] 大腸癌組織膜タンパク質の大規模プロテオーム解析によるバイオマーカー探索とSRM/MRM法を用いた定量法の確立および診断への応用2011
- Author(s)
  久米秀明
- Organizer
  日本分子生物学会
- Place of Presentation
  横浜
- Year and Date
  2011-12-14
- Data Source
  KAKENHI-PROJECT-22590545
[Presentation] 膜タンパク質の大規模プロテオーム解析による大腸癌バイオマーカーの探索とSRM法を用いた検証2011
- Author(s)
  久米秀明
- Organizer
  日本癌学会
- Place of Presentation
  名古屋
- Year and Date
  2011-10-04
- Data Source
  KAKENHI-PROJECT-22590545
[Presentation] 大腸癌バイオマーカーとなる膜タンパク質の大規模プロテオーム解析とSRMによる検証2011
- Author(s)
  久米秀明, 鳴海良平, 渡邉史生,石濱泰, 松原久裕, 小寺義男, 朝長毅
- Organizer
  第9回日本プロテオーム学会
- Place of Presentation
  新潟
- Year and Date
  2011-07-28
- Data Source
  KAKENHI-PROJECT-22590545
[Presentation] 大腸癌組織膜タンパク質のプロテオーム解析2010
- Author(s)
  久米秀明
- Organizer
  日本プロテオーム学会
- Place of Presentation
  舞浜
- Year and Date
  2010-07-27
- Data Source
  KAKENHI-PROJECT-22590545
[Presentation] 大腸癌組織膜タンパク質のプロテオーム解析2010
- Author(s)
  久米秀明
- Organizer
  日本癌学会
- Place of Presentation
  大阪
- Year and Date
  2010-09-24
- Data Source
  KAKENHI-PROJECT-22590545
[Presentation] 大腸癌の新たなバイオマーカーとなる膜タンパク質の探2010
- Author(s)
  久米秀明, 鳴海良平, 石濱泰, 松原久裕, 松下一之, 野村文夫,朝長毅
- Organizer
  第33回分子生物学会
- Place of Presentation
  神戸
- Year and Date
  2010-12-04
- Data Source
  KAKENHI-PROJECT-22590545
[Presentation] 大腸癌組織膜タンパク質のプロテオーム解析2010
- Author(s)
  久米秀明、鳴海良平、石濱泰、松原久裕、松下一之、野村文夫、朝長毅
- Organizer
  第8回日本プロテオーム学会
- Place of Presentation
  舞浜
- Year and Date
  2010-07-27
- Data Source
  KAKENHI-PROJECT-22590545
[Presentation] 大腸癌組織膜タンパク質のプロテオーム解析2010
- Author(s)
  久米秀明, 松原久裕, 松下一之,野村文夫,朝長毅
- Organizer
  第69回日本癌学会
- Place of Presentation
  大阪
- Year and Date
  2010-09-24
- Data Source
  KAKENHI-PROJECT-22590545
[Presentation] 大腸癌の新たなバイオマーカーとなる膜タンパク質の探索2010
- Author(s)
  久米秀明
- Organizer
  日本分子生物学会
- Place of Presentation
  神戸
- Year and Date
  2010-12-04
- Data Source
  KAKENHI-PROJECT-22590545
[Presentation] 血中膜小胞画分のプロテオーム解析による大腸癌バイオマーカーの探索
- Author(s)
  久米秀明、橋本裕希、村岡賢、松原久裕、朝長毅
- Organizer
  第1回日本細胞外小胞学会
- Place of Presentation
  広島
- Year and Date
  2014-08-28 – 2014-08-30
- Data Source
  KAKENHI-PROJECT-25460715
[Presentation] 血中膜小胞画分のプロテオーム解析による大腸癌バイオマーカータンパク質の探索
- Author(s)
  久米秀明、橋本裕希、村岡賢、松原久裕、朝長毅
- Organizer
  第12回日本プロテオーム学会
- Place of Presentation
  筑波
- Year and Date
  2014-07-17 – 2014-07-18
- Data Source
  KAKENHI-PROJECT-25460715
[Presentation] 大腸癌組織膜タンパク質のプロテオーム解析によるバイオマーカー探索とSRM/MRM法を用いたその検証
- Author(s)
  久米秀明、村岡賢、久家貴寿、足立淳、小寺義男、石濱泰、松原久裕、朝長毅
- Organizer
  第62回質量分析総合討論会
- Place of Presentation
  吹田
- Year and Date
  2014-05-14 – 2014-05-16
- Data Source
  KAKENHI-PROJECT-25460715

1. TOMONAGA Takeshi (80227644)

# of Collaborated Projects: 4 results

# of Collaborated Products: 23 results
2. TAKESHIMA Hiroshi (70212024)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. MATSUBARA Hisahiro (20282486)

# of Collaborated Projects: 2 results

# of Collaborated Products: 17 results
4. 東郷暁 (40282123)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. ISHIHAMA Yasushi (30439244)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
6. Hara Yasuhiro (70568617)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. Fujita Kazutoshi (50636181)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
8. MATSUZAKI Kyousuke (90747081)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
9. HAYASHI Takuji (50747079)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 足立淳 (20437255)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 根本康夫 (30250088)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 野々村祝夫 (30263263)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
13. 植村元秀 (40631015)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
14. MATSUMOTO Kazumasa

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 小寺義男

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
16. 佐藤雄一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KUME Hideaki 久米 秀明

久米 秀明 クメ ヒデアキ

Research Projects

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細胞外小胞を標的とした腫瘍マーカー探索Principal Investigator

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The analysis of prostate cancer exosome and the development of new urinary biomarker

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Comprehensive functional analysis of colorectal cancer biomarker candidates for the exploitation of diagnostic and therapeutic methods

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Proteomic analysis of membrane vesicles for elucidation of tumor communication mechanism and identification of tumor markersPrincipal Investigator

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Membrane proteomic analysis of cancer tissue for identification of biomarkers for early diagnosisPrincipal Investigator

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ミツグミン53に関する研究

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A study on the molecular hasis of intracellular Ca^<2+> stores

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[Journal Article] Proteomic analysis of urinary extracellular vesicles from high Gleason score prostate cancer.2017

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[Journal Article] Discovery of colorectal cancer biomarker candidates by membrane proteomic analysisand subsequent verification using selected reaction monitoring and tissue microarrayanalysis2014

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[Journal Article] A novel mechanism of keratin cytoskeleton organization through casein kinase I alpha and FAM83H in colorectal cancer.2013

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[Journal Article] In-depth Membrane Proteomic Study of Breast Cancer Tissues for the Generation of a Chromosome-based Protein List2012

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[Journal Article] Strategy for SRM-based verification of biomarker candidates discovered by iTRAQ method in limited breast cancer tissue samples.2012

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[Journal Article] A strategy for large-scale phosphoproteomics and SRM-based validation of human breast cancer tissue samples.2012

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[Patent] 大腸がんの判定方法2012

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KUME Hideaki 久米秀明

久米秀明クメヒデアキ