Takeshima Hiroshi 竹島浩

… Alternative Names

TAKESHIMA Hiroshi 竹島浩

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Researcher Number	70212024
Other IDs
External Links
Affiliation (Current)	2025: 京都大学, 薬学研究科, 教授
Affiliation (based on the past Project Information) *help	2016 – 2025: 京都大学, 薬学研究科, 教授 2012 – 2015: 京都大学, 薬学研究科(研究院), 教授 2011: 京都大学, 大学院・薬学研究科, 教授 2006 – 2011: 京都大学, 薬学研究科, 教授 2007: 京都大学, 大学院・薬学研究科, 教授 … More 2006: 京都大学, 大学院薬学系研究科, 教授 2005: 京都大学, 大学院・薬学研究科, 教授 2005: 東北大学, 大学院・医学系研究科, 非常勤講師 2004: Tohoku University, Graduate School of Medicine, Professor, 薬学研究科, 教授 2004: 東北大学, 医学系研究科, 教授 2001 – 2004: 東北大学, 大学院・医学系研究科, 教授 2000 – 2001: Institute of Life Science, Kurume University, 分子生命科学研究所, 教授 1997 – 1999: 東京大学, 大学院・医学系研究科, 助教授 1995 – 1997: 東京大学, 医学部, 助教授 1994 – 1995: 埼玉医科大学, 医学部, 講師 1994: 埼玉医科大学, 薬理学教室, 講師 1989 – 1991: 京都大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Biological Sciences / General pharmacology / Basic Section 48020:Physiology-related / General physiology / General medical chemistry / General medical chemistry / 広領域 / General physiology / Functional biochemistry / Cell biology … More / Neurophysiology and muscle physiology / Pathological medical chemistry / Biological pharmacy / Environmental physiology (including Physical medicine and Nutritional physiology) … More Except Principal Investigator Basic Section 53020:Cardiology-related / Basic Section 48020:Physiology-related / Biological Sciences / Basic Section 59020:Sports sciences-related / General pharmacology / Functional biochemistry / Biological Sciences Less
Keywords	Principal Investigator リアノジン受容体 / 小胞体 / TRICチャネル / ノックアウトマウス / Ca2+放出 / ジャンクトフィリン / ノシセプチン受容体 / ノシセプチン / ryanodine receptor / 筋収縮 … More / Ca2+ストア / カルシウムストア / カウンターイオン / 結合膜構造 / ミツグミン53 / Ca^<2+> release channel / caffeine / muscle contraction / カフェイン / 小胞体Ca2+放出 / Ca2+結合タンパク質 / Ca2+シグナル / 記憶学習 / イオンチャネル / junctophilin / 興奮収縮連関 / Ca^<2+>放出チャネル / 三つ組構造 / intracellular Ca^<2+> / カルシウム放出チャネル / リアノジン / 細胞内カルシウム / TRIM50 / 筋小胞体 / カルミン / 細胞内カルシウムストア / ミツグミン23 / 後過分極 / 神経可塑性 / 骨格筋 / TRIMファミリー / RBCCファミリー / シグナルシークエンストラップ法 / カルシウムシグナリング / 神経ペプチド / 疼痛 / 長期増強 / 聴覚調節 / オピオイド受容体 / オピオイドペプチド / マクロファージ / 成長板軟骨細胞 / MG23チャネル / Ca2+シグナリング / ＭＧ５６ / 骨芽細胞 / 生理学 / ミツグミン56 / channel crosstalk / junctional membrane complex / TRIC channel / Calumin / endoplasmic reticulum / Ca^<2+> release / ジャンクロフィリン / 興奮性細胞 / Ca2+依存性K+チャネル / K+チャネル / チャネル機能共役 / junctional membrane / calcium release / intracellular calcium ions / Ca^<2+>チャネル / Ca^<2+>ストア / カルシウム放出 / opioid receptors / opioids / nociceptin receptor / nociceptin / Ca^<2+> sigualing / fihydropyridina receptor / Excitation-contraction coupling / Ca^2^+シグナリング / Ca^2^+放出チャネル / Ca^<2+>シグナリング / ジヒドロピリジン受容体 / カルシウム・ストア / Ca^<2+> 放出チャネル / ryanodine / intracellular calcium / calcium release channel / カルシウム放出チャンネル / MG53 / Ca2+ポンプ / Ca2+取り込み / 小胞体Ca2+ / 高血圧 / 単粒子解析 / 脂質二重膜再構成 / Ca2+スパーク / ミツグミン２３ / 血管平滑筋 / microRNA / 病態マーカー / 遺伝子発現 / 筋委縮 / Ca2+ハンドリング / 心不全 / 加齢骨格筋 / 小胞体Ca2+ポンプ / サルカルメニン / Ca^<2+>ハンドリング / 筋萎縮 / 筋老化 / サルコペニア / IP3受容体 / 細胞内Ca^<2+>ストア / 膜タンパク質 / 小胞体ストレス / 容量依存性Ca2+流入 / Ca2+チャネル / 後科分極 / 筋ジストロフィー / 肺胞上皮細胞 / 膜修復 / 小胞体Ca^<2+>放出 / 心筋 / E3ユビキチンリガーゼ / エンドソーム / 細胞膜 / 骨格筋細胞 / 心筋細胞 / カリウムチャネル / 鎮痛薬 / 疼痛伝達 / ノシスタチン / 疼痛調節 / 蛋白リン酸化 / シグナル伝達 / 受容体 / 神経細胞 / オルファン受容体 / オピオイド耐性 / 疼痛反応 / G蛋白カップル受容体 / 鎖ノシセプチン / モルヒネ … More Except Principal Investigator カルシウム / リアノジン受容体 / 筋小胞体 / 遺伝子 / イオンチャネル / 興奮収縮連関 / イオン / マウス / 小胞体 / ノックアウトマウス / 骨格筋 / CaによるCa放出(CICR) / カルシウム放出チャネル / 大腸菌 / TRPP / 多発性嚢胞腎 / 腎臓 / 不活動 / 筋疲労 / カルシウム漏出 / 細胞内遊離Ca2+ / 骨格筋疲労 / スキンドファイバー / ミツグミン23 / 特発性心室細動 / リアノジン / 突然死 / 不整脈 / シミュレーション / 心室細動 / 心臓 / チャネル / Excitation-contraction coupling / Site-directed mutagenesis / cDNA expression / Muscarinic acetylcholine receptor / Ca^<2+> release channel / Ca^<2+> channel / Na^+ channel / Nicotinic acetylcholine receptor / ムスカリン性アセチルコリン受容体サブタイプ / E-C coupling / パッチクランプ法 / 電位感受機構 / K^+チャンネル / cGMP-gatedチャンネル / Ca^<2+> releaseチャンネル / グルタミン酸受容体 / 部位特異的変異 / 静位特異的変異 / cDNA発現 / ムスカリン性アセチルコリン受容体 / Ca^<2+>放出チャンネル / Ca^<2+>チャンネル / Na^+チャンネル / ニコチン性アセチルコリン受容体 / ion channel / cell, tissue / pharmaco logy / biotechnologv / physiology / gene / Ca^<2+>チャネル / Ca^<2+>シグナリング / 上皮細胞 / 生体分子 / 細胞・組織 / 薬理学 / バイオテクノロジー / 生理学 / calmodulin / excitation-contraction coupling (EC coupling) / skeletal muscle / sarcoplasmic reticulum / Ca-induced Ca release (CICR) / type 3 ryanodine receptor / type 1 ryanodine receptor / calcium release channel / 筋拘縮 / リアノジン受容体(脳型) / リアノジン受容体(骨格筋型) / カルモデュリン / Ca^<2+>によるCa^<2+>放出(CICR) / リアノジン受容体(3型) / リアノジン受容体(1型) / 生体恒常性 / ポンプ / 分子複合体 / 上皮輸送 / 生体膜 / 複合体 / トランスポーター / 膜輸送 / レニン / 近位尿細管 / 傍糸球体装置 / プロスタグランジン / 輸送体 / トランスフェリン受容体 / GAP / rho GTPase / リン脂質 / エンドサイトーシス / クラスリン / NFAT / リシ酸化 / 血管 / プルキンエ細胞 / イメージング / イノシトール三リン酸 / ミオシン / リン酸化 / 一酸化窒素 / 心臓副交感神経 / 心臓交感神経 / 心筋細胞 / 最大エントロピー法 / パワースペクトル / 心拍変動 / 蛍光カルシウム指示薬 / 画像解析 / 心筋 / リアノジン受容体欠損マウス(dyspedic mouse) / 骨格筋型,脳型リアノジン受容体 / スキンド・ファイバー / カルモジュリン / 分子生物学 / カルシウムイオン / ジーンターゲッティング / 筋収縮 / カルシウム放出チャンネル Less

電位依存性カルシウムチャネル・サブユニット間結合部位（ドメイン）の探索
- Principal Investigator
  
  村上アグニェシュカ
- Project Period (FY)
  2025 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Hirosaki University
TRPP3チャネルによる心筋・交感神経情報伝達系(cAMP系)への影響
- Principal Investigator
  
  村上学
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48020:Physiology-related
- Research Institution
  Hirosaki University
活動量の変化に伴う骨格筋の可塑的変化のメカニズムの解明
- Principal Investigator
  
  渡邊大輝
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59020:Sports sciences-related
- Research Institution
  Osaka University of Health and Sport Sciences
  National Cardiovascular Center Research Institute
TRIC and MG23 channels in store Ca2+ handlingPrincipal Investigator
- Principal Investigator
  
  Takeshima Hiroshi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 48020:Physiology-related
- Research Institution
  Kyoto University
Decreased cardiac pacemaking in TRIC-A knockout mice
- Principal Investigator
  
  Murakami Manabu
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48020:Physiology-related
- Research Institution
  Hirosaki University
The genetic analysis and underlying function of the endoplasmic reticulum membrane protein targeting inherited arrhythmogenic syndromes
- Principal Investigator
  
  Itoh Hideki
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Hiroshima University
Study on TRIC and MG23 channelsPrincipal Investigator
- Principal Investigator
  
  Takeshima Hiroshi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 48020:Physiology-related
- Research Institution
  Kyoto University
Study on TRIC channel and MG56Principal Investigator
- Principal Investigator
  
  Takeshima Hiroshi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General physiology
- Research Institution
  Kyoto University
Vesicular dynamics in parietal and muscle cellsPrincipal Investigator
- Principal Investigator
  
  Takeshima Hiroshi
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Functional biochemistry
- Research Institution
  Kyoto University
Counter ion movement during Ca2+ releasePrincipal Investigator
- Principal Investigator
  
  TAKESHIMA Hiroshi
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Cell biology
- Research Institution
  Kyoto University
Study of TRIC and MG23 channelsPrincipal Investigator
- Principal Investigator
  
  TAKESHIMA Hiroshi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Neurophysiology and muscle physiology
- Research Institution
  Kyoto University
Identification of muscular senescence-related genesPrincipal Investigator
- Principal Investigator
  
  TAKESHIMA Hiroshi
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Kyoto University
Roles of novel intracellular ion channelsPrincipal Investigator
- Principal Investigator
  
  TAKESHIMA Hiroshi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Biological pharmacy
- Research Institution
  Kyoto University
Channel micro-assembly in junctional membrane complexesPrincipal Investigator
- Principal Investigator
  
  TAKESHIMA Hiroshi
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
  Tohoku University
Transportsome on biomembrane systems: its molecular assembly and physiological function.
- Principal Investigator
  
  KANAI Yoshikatsu
- Project Period (FY)
  2005 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
  Kyorin University
新規小胞体膜タンパク質CSNの構造と機能Principal Investigator
- Principal Investigator
  
  竹島浩
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  General physiology
- Research Institution
  Kyoto University
  Tohoku University
中枢神経系におけるジャンクトフィリンの生理機能Principal Investigator
- Principal Investigator
  
  竹島浩
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
ミツグミン53に関する研究Principal Investigator
- Principal Investigator
  
  竹島浩
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
エンドフィリン複合体のクラスリンを介するエンドサイトーシスにおける機能の解析
- Principal Investigator
  
  根本康夫
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  Tohoku University
A study on the molecular hasis of intracellular Ca^<2+> storesPrincipal Investigator
- Principal Investigator
 
 TAKESHIMA Hiroshi
- Project Period (FY)
 2003 – 2007
- Research Category
 
 Grant-in-Aid for Scientific Research (S)
- Research Field
 
 General medical chemistry
- Research Institution
 Kyoto University
 Tohoku University
3型ジャンクトフィリンとハンチントン類似病Principal Investigator
- Principal Investigator
  
  竹島浩
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
新規受容体蛋白ファミリーの機能解析Principal Investigator
- Principal Investigator
  
  竹島浩
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
  Kurume University
ノシセプチン受容体欠損マウスにおける中枢機能の補充機序Principal Investigator
- Principal Investigator
  
  竹島浩
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Environmental physiology (including Physical medicine and Nutritional physiology)
- Research Institution
  Tohoku University
Structure and function of ryanodine receptorPrincipal Investigator
- Principal Investigator
  
  TAKESHIMA Hiroshi
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Tokoku University
  Kurume University
細胞内シグナルフローの可視化解析
- Principal Investigator
  
  飯野正光
- Project Period (FY)
  2000 – 2004
- Research Category
  
  Grant-in-Aid for Specially Promoted Research
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Molecular physiological characterization of Ca2+ signal-regulating ion channels that control vectorial substance transport
- Principal Investigator
  
  MORI Eyasuo
- Project Period (FY)
  2000 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University, Graduate School of Engineering
  Okazaki National Research Institutes
Molecular contraction of Ca^<2+> signalingPrincipal Investigator
- Principal Investigator
 
 TAKESHIMA Hiroshi
- Project Period (FY)
 1999 – 2000
- Research Category
 
 Grant-in-Aid for Scientific Research (B).
- Research Field
 
 General pharmacology
- Research Institution
 Institute of Life Science, Kurume University
 The University of Tokyo
Nociceptin receptor antagonistPrincipal Investigator
- Principal Investigator
  
  TAKESHIMA Hiroshi
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  広領域
- Research Institution
  Institute of Life Science, Kurume University
  The University of Tokyo
ノシセプチン受容体による記憶学習および長期増強の調節Principal Investigator
- Principal Investigator
  
  竹島浩
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  The University of Tokyo
記憶学習とオピオイド耐性における可塑性へのノシセプチン系の関与Principal Investigator
- Principal Investigator
  
  竹島浩
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  The University of Tokyo
新規神経ペプチドの検索と単離Principal Investigator
- Principal Investigator
  
  竹島浩
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  General pharmacology
- Research Institution
  The University of Tokyo
リマノジンタイプ3受容体欠損マウスの体温および自律神経調節機能の研究
- Principal Investigator
  
  桑木共之
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Chiba University
Structure and function of ryanodine receptorsPrincipal Investigator
- Principal Investigator
  
  TAKESHIMA Hiroshi
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  The University of Tokyo
興奮収縮連関機構の構造機能協関
- Principal Investigator
  
  飯野正光
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
オピオイド受容体相同物(ROR-C,MOR-C)の中枢神経系における機能Principal Investigator
- Principal Investigator
  
  竹島浩
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  General pharmacology
- Research Institution
  The University of Tokyo
Functional analysis of ryanodine receptor using molecular genetic techniquePrincipal Investigator
- Principal Investigator
  
  TAKESHIMA Hiroshi
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  University of Tokyo
骨格筋小胞体カルシウム放出チャネルとカルシウムポンプの機能協関
- Principal Investigator
  
  ENDO Makoto
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Saitama Medical University
オピオイド受容体分子のジーンターゲッティングによる生理機能解析Principal Investigator
- Principal Investigator
  
  竹島浩
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Saitama Medical University
Functions of the two types of calcium release channels in the sarcoplasmic reticulum of skeletal muscle.
- Principal Investigator
  
  ENDO Makoto
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  Saitama Medical School
リアノジン受容体/カルシウム放出チャンネル遺伝子欠失マウスの作製と解析
- Principal Investigator
  
  竹島美幸
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo Institute of Psychiatry
Molecular biological studies of ryanodine receptor/calcium release channelPrincipal Investigator
- Principal Investigator
  
  TAKESHIMA Hiroshi
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  General physiology
- Research Institution
  Saitama Medical School
Studies on the structure and function of neurotransmitter receptors and ionic channels
- Principal Investigator
  
  NUMA Shosaku
- Project Period (FY)
  1988 – 1991
- Research Category
  
  Grant-in-Aid for Specially Promoted Research
- Research Institution
  Kyoto University

[Book] リアノジン受容体を介するチャネル共役による神経機能,脳21(vol. 16)2013
- Author(s)
  竹島浩
- Data Source
  KAKENHI-PROJECT-24657133
[Book] TRIC チャネルと高血圧2013
- Author(s)
  山崎大樹、陶晟辰、竹島浩
- Publisher
  Clinical Calcium
- Data Source
  KAKENHI-PROJECT-23240055
[Book] トランスポートソームの世界2011
- Author(s)
  金井好克、竹島浩、森泰生、久保義弘編集
- Total Pages
  471
- Publisher
  京都廣川書店
- Data Source
  KAKENHI-PROJECT-20249004
[Book] トランスポートソームの世界2010
- Author(s)
  金井好克、竹島浩、森泰生、久保義弘
- Total Pages
  471
- Publisher
  京都廣川書店
- Data Source
  KAKENHI-PROJECT-20249004
[Book] Junctophilin. Encyclopedia of movement disorders.2009
- Author(s)
  Takeshima, H.
- Publisher
  Elsevier Limitted
- Data Source
  KAKENHI-PROJECT-17081001
[Book] 医歯薬系学生のための基礎生命科学2008
- Author(s)
  竹島浩、山崎哲男、池田篤史、輿水崇鏡
- Total Pages
  214
- Publisher
  京都廣川書店
- Data Source
  KAKENHI-PROJECT-17081001
[Book] イオンチャネル最前線(リアノジン受容体, 医学のあゆみ別冊)2005
- Author(s)
  竹島浩
- Data Source
  KAKENHI-PROJECT-17081001
[Book] イオンチャネル最前線(医学のあゆみ別冊)2005
- Author(s)
  竹島浩
- Publisher
  共立出版
- Data Source
  KAKENHI-PROJECT-15109005
[Book] イオンチャネル最前線(医学のあゆみ別冊)2005
- Author(s)
  竹島浩
- Publisher
  共立出版
- Data Source
  KAKENHI-PROJECT-17081015
[Book] イオンチャネル最前線(医学のあゆみ別冊),pp.171-175担当2005
- Author(s)
  竹島浩
- Total Pages
  273
- Publisher
  共立出版
- Data Source
  KAKENHI-PROJECT-17659060
[Book] イオンチャネル最前線(医学のあゆみ別冊),pp.171-175担当2005
- Author(s)
  竹島浩
- Total Pages
  273
- Publisher
  共立出版
- Data Source
  KAKENHI-PROJECT-17081001
[Book] Ryanodine receptors 14 (Knockout mice lacking rqanoclire receptor and junctophiline subtypes.)(ed.Wehrens XHT, Marks AR)2004
- Author(s)
  Takeshima H.
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-12144210
[Journal Article] Ca2+ storage function is altered in the sarcoplasmic reticulum of skeletal muscle lacking mitsugumin 232024
- Author(s)
 Watanabe Daiki、Nishi Miyuki、Liu Feng、Bian Yuhan、Takeshima Hiroshi
- Journal Title
 
 American Journal of Physiology-Cell Physiology
 
 Volume: 326 Issue: 3 Pages: C795-C809
- DOI
 10.1152/ajpcell.00440.2023
- Peer Reviewed / Open Access
- Data Source
 KAKENHI-PROJECT-23K10634, KAKENHI-PROJECT-21H02663, KAKENHI-PROJECT-23K24738
[Journal Article] Soluble epoxide hydrolase maintains steady-state lipid turnover linked with autocrine signaling in peritoneal macrophages.2023
- Author(s)
  Liu, F., Diao, X., Cong, H., Suzuki, E., Hasumi, K. & Takeshima, H.
- Journal Title
  
  iScience
  
  Volume: 26 Issue: 8 Pages: 107465-107465
- DOI
  10.1016/j.isci.2023.107465
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H02663
[Journal Article] Cardiac glycosides stimulate endocytosis of GLUT1 via intracellular Na+,K+‐ATPase α3‐isoform in human cancer cells2022
- Author(s)
  Fujii Takuto、Katoh Mizuki、Ootsubo Manami、Nguyen Oanh T. T.、Iguchi Mayumi、Shimizu Takahiro、Tabuchi Yoshiaki、Shimizu Yasuharu、Takeshima Hiroshi、Sakai Hideki
- Journal Title
  
  Journal of Cellular Physiology
  
  Volume: 237 Issue: 7 Pages: 2980-2991
- DOI
  10.1002/jcp.30762
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06827, KAKENHI-PROJECT-21H02663, KAKENHI-PROJECT-20K07258
[Journal Article] C-type natriuretic peptide facilitates autonomic Ca 2+ entry in growth plate chondrocytes for stimulating bone growth2022
- Author(s)
  Yuu Miyazaki#, Atsuhiko Ichimura#, Ryo Kitayama, Naoki Okamoto, Tomoki Yasue, Feng Liu, Takaaki Kawabe, Hiroki Nagatomo, Yohei Ueda, Ichiro Yamauchi, Takuro Hakata, Kazumasa Nakao, Sho Kakizawa, Miyuki Nishi, Yasuo Mori, Haruhiko Akiyama, Kazuwa Nakao, Hiroshi Takeshima
- Journal Title
  
  eLife
  
  Volume: 11
- DOI
  10.7554/elife.71931
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03802, KAKENHI-PROJECT-21H02663, KAKENHI-PROJECT-21K19565, KAKENHI-PROJECT-19K06955, KAKENHI-PROJECT-20K11306, KAKENHI-PROJECT-21K19752
[Journal Article] Enhanced Ca2+ handling in thioglycolate-elicited peritoneal macrophages2021
- Author(s)
  Liu Feng、Xu Luxin、Nishi Miyuki、Ichimura Atsuhiko、Takeshima Hiroshi
- Journal Title
  
  Cell Calcium
  
  Volume: 96 Pages: 102381-102381
- DOI
  10.1016/j.ceca.2021.102381
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K11306, KAKENHI-PROJECT-18H02597, KAKENHI-PROJECT-20H03802, KAKENHI-PROJECT-21H02663
[Journal Article] TRIC-A Channel Maintains Store Calcium Handling by Interacting With Type 2 Ryanodine Receptor in Cardiac Muscle2020
- Author(s)
  Zhou X, Park KH, Yamazaki D, Lin PH, Nishi M, Ma Z, Qiu L, Murayama T, Zou X, Takeshima H, Zhou J, Ma J.
- Journal Title
  
  Circulation Reserach
  
  Volume: 126 Issue: 4 Pages: 417-435
- DOI
  10.1161/circresaha.119.316241
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07313, KAKENHI-PROJECT-16K08507, KAKENHI-PROJECT-17K01845, KAKENHI-PROJECT-19H03404, KAKENHI-PROJECT-18H02597
[Journal Article] Decreased cardiac pacemaking and attenuated b-adrenergic response in TRIC-A knockout mice.2020
- Author(s)
  Murakami, M., Toyama, Y., Yonekura, M., Ohba, T., Matsuzaki, Y., Sawamura, D., Murakami, A. M., Nishi, M., Itagaki, S., Tomita, H. & Takeshima, H. 15, 2020. Doi:
- Journal Title
  
  PLOS One
  
  Volume: 15 Issue: 6 Pages: e0230465-e0230465
- DOI
  10.1371/journal.pone.0230465
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02597
[Journal Article] Decreased cardiac pacemaking and attenuated beta-adrenergic response in TRIC-A knockout mice.2020
- Author(s)
  Murakami M, Toyama Y, Yonekura M, Ohba T, Matsuzaki Y, Sawamura D, Murakami AM, Nishi M, Itagaki S, Tomita H, Takeshima H.
- Journal Title
  
  Plos ONE
  
  Volume: 15 Issue: 12 Pages: 1-12
- DOI
  10.1371/journal.pone.0244254
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07255, KAKENHI-PROJECT-20K08665, KAKENHI-PROJECT-20K11306, KAKENHI-PROJECT-17H04319, KAKENHI-PROJECT-18K08286
[Journal Article] 遺伝性不整脈疾患における筋小胞体Caシグナリング2020
- Author(s)
  伊藤英樹、堀江　稔、竹島　浩
- Journal Title
  
  Bio Clinica
  
  Volume: 35 Pages: 76-79
- Data Source
  KAKENHI-PROJECT-20K08473
[Journal Article] Enhanced activity of multiple TRIC-B channels; an ER/SR mechanism to boost counterion currents.2019
- Author(s)
  O'Brien F, Eberhardt D, Witschas K, El-Ajouz S, Iida T, Nishi M, Takeshima H, Sitsapesan R, Venturi E.
- Journal Title
  
  J Physiol.
  
  Volume: 印刷中 Issue: 10 Pages: 2691-2705
- DOI
  10.1113/jp277241
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01845, KAKENHI-PROJECT-18H02597
[Journal Article] TRPM7 channels mediate spontaneous Ca2+ fluctuations in growth plate chondrocytes that promote bone development.2019
- Author(s)
  Qian N, Ichimura A, Takei D, Sakaguchi R, Kitani A, Nagaoka R, Tomizawa M, Miyazaki Y, Miyachi H, Numata T, Kakizawa S, Nishi M, Mori Y, Takeshima H.
- Journal Title
  
  Science signaling
  
  Volume: 12 Issue: 576 Pages: 4847-4847
- DOI
  10.1126/scisignal.aaw4847
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01845, KAKENHI-PROJECT-18H02597, KAKENHI-PROJECT-15K06774, KAKENHI-PROJECT-18K11044, KAKENHI-PROJECT-18K06864, KAKENHI-PROJECT-19K06955, KAKENHI-PROJECT-19K22834, KAKENHI-PUBLICLY-18H04695, KAKENHI-PROJECT-16K05843, KAKENHI-PLANNED-26111004, KAKENHI-PROJECT-17H06228
[Journal Article] Dampened activity of ryanodine receptor channels in mutant skeletal muscle lacking TRIC-A.2017
- Author(s)
  El-Ajouz S, Venturi E, Witschas K, Beech M, Wilson AD, Lindsay C, Eberhardt D, O'Brien F, Iida T, Nishi M, Takeshima H, Sitsapesan R.
- Journal Title
  
  J Physiol.
  
  Volume: 595 Issue: 14 Pages: 4769-4784
- DOI
  10.1113/jp273550
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01845, KAKENHI-PROJECT-15H04676
[Journal Article] Gm7325 is MyoD-dependently expressed in activated muscle satellite cells 2017
- Author(s)
 Takei D, Nishi M, Fukada S, Doi M, Okamura H, Uezumi A, Zhang L, Yoshida M, Miyazato M, Ichimura A, Takeshima H.
- Journal Title
 
 Biomed. Res.
 
 Volume: 38 Issue: 3 Pages: 215-219
- DOI
 10.2220/biomedres.38.215
- NAID
 130006865614
- ISSN
 0388-6107, 1880-313X
- Language
 English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
 KAKENHI-PROJECT-17K01845, KAKENHI-PLANNED-15H05933, KAKENHI-PROJECT-15H01843, KAKENHI-PROJECT-17H01524, KAKENHI-PROJECT-15H04676, KAKENHI-PROJECT-15H05652
[Journal Article] Mice lacking the intracellular cation channel TRIC-B have compromised collagen production and impaired bone mineralization.2016
- Author(s)
  C.Zhao, A.Ichimura, N.Qian, T.Iida, D.Yamazaki, N.Noma, M.Asagiri, K.Yamamoto, S.Komazaki, C.Sato, F.Aoyama, A.Sawaguchi, S.Kakizawa, M.Nishi, and H.Takeshima.
- Journal Title
  
  science signaling
  
  Volume: 9 Issue: 428
- DOI
  10.1126/scisignal.aad9055
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-16H01562, KAKENHI-PROJECT-15H04676, KAKENHI-PROJECT-15H04698, KAKENHI-PROJECT-15H05652, KAKENHI-PROJECT-14J06672, KAKENHI-PROJECT-15K06774, KAKENHI-PROJECT-15K14499
[Journal Article] Seizure protein 6 and its homolog seizure 6-like protein are physiological substrates of BACE1 in neurons.2016
- Author(s)
  Pigoni, M., Johanna Wanngren, J., Kuhn, J-H., Munro, K. M., Jenny M. Gunnersen, J. M., Takeshima, H., Feederle, R., Voytyuk, I., Strooper, B. D., Levasseur, M. D., Hrupka, B. J., Stephan, A., Müller, S. A. & Lichtenthaler, S. F.
- Journal Title
  
  Mol. Neurodegener.
  
  Volume: 11 Issue: 1 Pages: 67-67
- DOI
  10.1186/s13024-016-0134-z
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04676
[Journal Article] Positive regulation of the enzymatic activity of gastric H+,K+-ATPase by sialylation of its β-subunit.2016
- Author(s)
  Fujii T, Watanabe M, Shimizu T, Takeshima H, Kushiro K, Takai M, Sakai H.
- Journal Title
  
  Biochim. Biophys. Acta.
  
  Volume: 1858 Issue: 6 Pages: 1228-1235
- DOI
  10.1016/j.bbamem.2016.02.029
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460291, KAKENHI-PROJECT-15K15029, KAKENHI-PROJECT-25460282, KAKENHI-PROJECT-26870166, KAKENHI-PROJECT-25293047, KAKENHI-PROJECT-15H04676, KAKENHI-PROJECT-16K08490
[Journal Article] TRIM72 modulates Caveolar endocytosis in repair of lung cells.2015
- Author(s)
  Nagre, N., Wang, S., Kellett, T., Kanagasabai, R., Deng, J., Nishi, M., Shilo, K., Oeckler, R., Yalowich, J., Takeshima, H., Christman, J., Hubmayr, R. & Zhao, Z.
- Journal Title
  
  Am. J. Physiol. Lung Cell. Mol. Physiol.
  
  Volume: 310 Issue: 5 Pages: L452-L464
- DOI
  10.1152/ajplung.00089.2015
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26650034
[Journal Article] Mitsugumin 56 (hedgehog acyltransferase-like) is a sarcoplasmic reticulum-resident protein essential for postnatal muscle maturation.2015
- Author(s)
  Van B, Nishi M, Komazaki S, Ichimura A, Kakizawa S, Nakanaga K, Aoki J, Park KH, Ma J, Ueyama T, Ogata T, Maruyama N, Takeshima H.
- Journal Title
  
  FEBS Lett.
  
  Volume: in press Issue: 10 Pages: 1095-1104
- DOI
  10.1016/j.febslet.2015.03.028
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24500470, KAKENHI-PROJECT-15K06774, KAKENHI-PROJECT-15H04676, KAKENHI-PROJECT-15H05652
[Journal Article] Ca2+ microdomains organized by junctophilins2015
- Author(s)
  Takeshima, H., Hoshijima, M. & Song, L-S.
- Journal Title
  
  Cell Calcium
  
  Volume: ５８ Issue: 4 Pages: 349-356
- DOI
  10.1016/j.ceca.2015.01.007
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04676
[Journal Article] Trimeric intracellular cation channels and sarcoplasmic/endoplasmic reticulum calcium homeostasis2014
- Author(s)
  Zhou, X., Lin, P., Yamazaki, D., Park, K-H., Komazaki, S., Chen, R. S. W., Takeshima, H. & Ma, J. .
- Journal Title
  
  Circ. Res.
  
  Volume: 114 Pages: 706-716
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26650034
[Journal Article] Trimeric intracellular cation channels and sarcoplasmic/endoplasmic reticulum calcium homeostasis2014
- Author(s)
  Zhou, X., Lin, P., Yamazaki, D., Park, K-H., Komazaki, S., Chen, R. S. W., Takeshima, H. & Ma, J.
- Journal Title
  
  Circ. Res
  
  Volume: 114 Pages: 706-716
- Data Source
  KAKENHI-PROJECT-24657133
[Journal Article] Facilitated hyperpolarization signaling in vascular smooth muscle overexpressing TRIC-A channels.2013
- Author(s)
  Tao, S., Yamazaki, D., Komazaki, S., Zhao, C., Iida, T., Kakizawa, S., Imaizumi, Y. & Takeshima, H.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 288 Issue: 22 Pages: 15581-15589
- DOI
  10.1074/jbc.m112.435396
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23240055, KAKENHI-PROJECT-23390020, KAKENHI-PROJECT-23659037, KAKENHI-PUBLICLY-24111528, KAKENHI-PROJECT-24659131, KAKENHI-PROJECT-24680041, KAKENHI-PUBLICLY-25136717
[Journal Article] TRIC channels supporting efficient Ca^<2+> release from intracellular stores2013
- Author(s)
 Venturi, E., Sitsapesan, R., Yamazaki, D. & Takeshima, H
- Journal Title
 
 Pflugers Arch
 
 Volume: 465 Pages: 187-195
- Data Source
 KAKENHI-PROJECT-23240055
[Journal Article] Enhanced dihydropyridine receptor calcium channel activity improves skeletal muscle strength2013
- Author(s)
  Mosca, B., Bergamelli, L., Vukcevic, M, Lopez, R., Treves, S., Nishi, M., Takeshima, H., Paolini, C., Martini, M., Rispoli, G., Protasi, F. & Zorzato, F.
- Journal Title
  
  Nat. Commun
  
  Volume: 4 Pages: 1541-1541
- Data Source
  KAKENHI-PROJECT-24657133
[Journal Article] Enhanced dihydropyridine receptor calcium channel activity improves skeletal muscle strength2013
- Author(s)
  Mosca, B., Bergamelli, L., Vukcevic, M, Lopez, R., Treves, S., Nishi, M., Takeshima, H., Paolini, C., Martini, M., Rispoli, G., Protasi, F. & Zorzato, F
- Journal Title
  
  Nat. Commun
  
  Volume: 4 Pages: 1541-1541
- Data Source
  KAKENHI-PROJECT-23240055
[Journal Article] TRIC-B channels display labile gating: evidence from the TRIC-A knockout mouse model.2013
- Author(s)
  Venturi, E., Matyjaszkiewicz, A., Pitt, S. J., Tsaneva-Atanasova, K., Nishi, M., Yamazaki, D., Takeshima, H. & Sitsapesan, R.
- Journal Title
  
  Pflugers Arch.
  
  Volume: 465 Issue: 8 Pages: 1135-1148
- DOI
  10.1007/s00424-013-1251-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23240055, KAKENHI-PROJECT-24500470, KAKENHI-PROJECT-24659131
[Journal Article] Facilitated hyperpolarization signaling in vascular smooth muscle overexpressing TRIC-A channels2013
- Author(s)
  Tao, S., Yamazaki, D., Komazaki, S., Zhao, C., Iida, T., Kakizawa, S., Imaizumi, Y. & Takeshima, H
- Journal Title
  
  J. Biol. Chem
  
  Volume: 288 Pages: 15581-15589
- Data Source
  KAKENHI-PROJECT-23240055
[Journal Article] TRIC-B channels display labile gating : evidence from the TRIC-A knockout mouse model2013
- Author(s)
  Venturi, E., Matyjaszkiewicz, A., Pitt, S J., Tsaneva-Atanasova, K., Nishi, M., Yamazaki, D., Takeshima, H. & Sitsapesan, R
- Journal Title
  
  Pflugers Arch
  
  Volume: 465 Pages: 1135-1148
- Data Source
  KAKENHI-PROJECT-23240055
[Journal Article] Sarcalumenin plays a critical role in age-related cardiac dysfunction due to decreases in SERCA2a expression and activity.2012
- Author(s)
  Jiao Q, et al.
- Journal Title
  
  Cell Calcium.
  
  Volume: 51 Issue: 1 Pages: 31-39
- DOI
  10.1016/j.ceca.2011.10.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11F01418, KAKENHI-PLANNED-22136009, KAKENHI-PROJECT-22659066, KAKENHI-PROJECT-24390200, KAKENHI-PUBLICLY-23136516
[Journal Article] TRIM50 regulates vesicular trafficking for acid secretion in gastric parietal cells.2012
- Author(s)
  Nishi, M., Aoyama, F., Kisa, F., Zhu, H., Sun, M., Lin, P., Ohta, H., Yamamoto, S., Kakizawa, S., Sakai, H., Ma, J., Sawaguchi, A. & Takeshima, H.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 287 Issue: 40 Pages: 33523-33532
- DOI
  10.1074/jbc.m112.370551
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23240055, KAKENHI-PROJECT-24500470, KAKENHI-PROJECT-24659095, KAKENHI-PROJECT-24790073
[Journal Article] Recombinant human MG53 protein modulates therapeutic cell membrane repair.2012
- Author(s)
  Weisleder N, Takizawa N, Lin P, Wang X, Cao C, Zhang Y, Tan T, Ferrante C, Zhu H, Chen P-J, Yan R, Sterling M, Zhao X, Hwang M, Cai C, Cheng H, Takeshima H, Xiao R. & Ma J.
- Journal Title
  
  Sci. Transl. Med.
  
  Volume: 4 Issue: 139 Pages: 1-10
- DOI
  10.1126/scitranslmed.3003921
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23240055, KAKENHI-PROJECT-24500470
[Journal Article] Sarcalumenin plays a critical role in age-related cardiac dysfunction due to decreases in SERCA2a expression and activity2012
- Author(s)
  Jiao, Q., Takeshima, H., Ishikawa, Y. & Minamisawa, S
- Journal Title
  
  Cell Calcium
  
  Volume: 51 Pages: 31-39
- Data Source
  KAKENHI-PROJECT-23240055
[Journal Article] Endogenously determined restriction of food intake overcomes excitation-contraction uncoupling in JP45KO mice with aging2012
- Author(s)
  Delbono, O., Messi M. L., Wang, Z., Treves, S., Mosca, B., Bergamelli, L., Nishi, M., Takeshima, H., Shi H., Xue B. & Zorzato, F
- Journal Title
  
  Exp. Gerontol
  
  Volume: 4 Issue: 4 Pages: 304-316
- DOI
  10.1016/j.exger.2012.01.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500382, KAKENHI-PROJECT-22659066, KAKENHI-PROJECT-24500470
[Journal Article] TRIM50 regulates vesicular trafficking for acid secretion in gastric parietal cells2012
- Author(s)
  Nishi, M., Aoyama, F., Kisa, F., Zhu, H., Sun, M., Lin, P., Ohta, H., Yamamoto, S., Kakizawa, S., Sakai, H., Ma, J., Sawaguchi, A. & Takeshima, H
- Journal Title
  
  J. Biol. Chem
  
  Volume: 287 Pages: 33523-33532
- Data Source
  KAKENHI-PROJECT-23240055
[Journal Article] Mitsugumin 23 forms massive bowl-shaped assembly and cation-selective channel2011
- Author(s)
  Venturi, E., Mio, K., Nishi, M., Ogura, T., Moriya, T., Okuda, K., Kakizawa, S., Sitapeasan, R., Chikara Sato, C. & Takeshima, H
- Journal Title
  
  Biochemistry
  
  Volume: 50 Pages: 2623-2632
- Data Source
  KAKENHI-PROJECT-23240055
[Journal Article] TRIC-A channels in vascular smooth muscle contribute to blood pressure maintenance2011
- Author(s)
  Yamazaki D, Tabara Y, Kita S, Hanada H, Komazaki S, Naitou D, Mishima A, Nishi M, Yamamura H, Yamamoto S, Kakizawa S, Miyachi H, Yamamoto S, Miyata T, Kawano Y, Kamide K, Ogihara T, Hata A, Umemura S, Soma M, Takahashi N, Imaizumi Y, Miki T, Iwamoto T, Ta
- Journal Title
  
  Cell Metab
  
  Volume: 14 Issue: 2 Pages: 231
- DOI
  10.1016/j.cmet.2011.05.011
- NAID
  120003255678
- URL
  http://hdl.handle.net/2433/143634
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390185, KAKENHI-PROJECT-21500382, KAKENHI-PROJECT-22590254, KAKENHI-PROJECT-22790209, KAKENHI-PROJECT-22790288, KAKENHI-PUBLICLY-23136506, KAKENHI-PUBLICLY-23136512, KAKENHI-PROJECT-23240055, KAKENHI-PROJECT-23390020, KAKENHI-PROJECT-23590319, KAKENHI-PROJECT-23659037, KAKENHI-PROJECT-23790092
[Journal Article] TRIC-A channels in vascular smooth muscle contribute to blood pressure maintenance2011
- Author(s)
  Yamazaki, D., Tabara, Y., Kita, S., Hanada, H., Komazaki, S., Naitou, D., Mishima, A., Nishi, M., Yamamura, H., Yamamoto, S., Kakizawa, S., Miyachi, H., Yamamoto, S., Miyata, T., Kawano, Y., Kamide, K., Ogihara, T., Hata, A., Umemura, S., Soma, M., Takahashi, N., Imaizumi, Y., Miki, T., Iwamoto, T. & Takeshima, H
- Journal Title
  
  Cell Metab
  
  Volume: 14 Pages: 231-241
- NAID
  120003255678
- Data Source
  KAKENHI-PROJECT-23240055
[Journal Article] Facilitation of DNA damage-induced apoptosis by endoplasmic reticulum protein mitsugumin23.2010
- Author(s)
  Yamazaki, T., Sasaki, N., Nishi, M., Takeshima, H.
- Journal Title
  
  Biochem. Biophys. Res. Commun. 396
  
  Pages: 196-200
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249004
[Journal Article] Charade of the SR K^+-channel : two ion-channels, TRIC-A and TRIC-B, masquerade as a single K^+-channel.2010
- Author(s)
  Pitt SJ, Park K-H, Nishi M, Urashima T, Aoki S, Yamazaki D, Ma J, Takeshima H., Sitsapesan R.
- Journal Title
  
  Biophys.J.
  
  Volume: 99 Pages: 417-426
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249004
[Journal Article] Charade of the SR K^<+->channel : two ion-channels, TRIC-A and TRIC-B, masquerade as a single K^<+->channel.2010
- Author(s)
 Pitt S J, Park K-H, Nishi M, Takeshima H, et al.
- Journal Title
 
 Biophys.J.
 
 Volume: 99 Pages: 417-426
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-17081015
[Journal Article] Imparied Orail-mediateded resting Ca^<2+> entry reduces the cytosolic [Ca^<2+>] and SR Ca^<2+> loading in quitescent junctophilinl knockout myotubes.2010
- Author(s)
 Li, H., Ding, X., Lopez, J.R., Takeshima, H., Ma, J., Allen, P.D., Eltit, J.M.
- Journal Title
 
 J.Biol.Chem. 285
 
 Pages: 39171-39179
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-20249004
[Journal Article] Impaired Orail-mediated resting Ca^<2+> entry reduces the cytosolic [Ca^<2+>] and SR Ca^<2+> loading in quitescent junctophilin1 knockout myotubes.2010
- Author(s)
 Li H, Ding X, Lopez JR, Takeshima H, Ma J, Allen PD, Eltit JM.
- Journal Title
 
 J.Biol.Chem.
 
 Volume: 285 Pages: 39171-39179
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-22659066
[Journal Article] Ca^<2+> overload and sarcoplasmic reticulum instability in tric-a null skeletal muscle.2010
- Author(s)
 Zhao X, Yamazaki D, Park K-H, Komazaki S, Tjondrokoesoemo A, Nishi M, Hirata Y, Brotto M, Takeshima H., Ma, J.
- Journal Title
 
 J.Biol.Chem.
 
 Volume: 285 Pages: 37370-37376
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-20249004
[Journal Article] MG53 constitutes a primary determinant of cardiac ischemic preconditioning.2010
- Author(s)
  Cao, C-M., Zhang, Y., Weisleder, N., Ferrante, C., Wang, X., Lv, F., Zhang, Y., Song, R., Hwang, M., Jin, L., Guo, J., Peng, W., Li, G., Nishi, M., Takeshima, H., Ma, J., Xiao, R-P.
- Journal Title
  
  Circulation 121
  
  Pages: 2565-2574
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249004
[Journal Article] Facilitation of DNA damage- induced apoptosis by endoplasmic reticulum protein mitsugumin23.2010
- Author(s)
  Yamazaki, T., Sasaki, N., Nishi, M., Takeshima, H.
- Journal Title
  
  Biochem.Biophys.Res. Commun. 392
  
  Pages: 196-200
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249004
[Journal Article] Molecular characterization of flubendiamide sensitivity in Iepidopterous ryanodine receptor.2010
- Author(s)
  Kato, K., Kiyonaka, S., Sawaguchi, Y., Tohnish, M., Masaki, T., Yasokawa, N., Mizuno, Y., Mori, E., Inoue, K., Hamachi, I., Takeshima, H., Mori, Y.
- Journal Title
  
  Biochemistry 48
  
  Pages: 10342-10352
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249004
[Journal Article] Imparied Orail-mediateded resting Ca^<2+> entry reduces the cytosolic [Ca^<2+>] and SR Ca^<2+> loading in quitescent junctophilin1 knockout myotubes.2010
- Author(s)
 Li H, Ding X, Lopez J R, Takeshima H, Ma J, Allen P D, Eltit J M.
- Journal Title
 
 J.Biol.Chem.
 
 Volume: 285 Pages: 39171-39179
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-17081015
[Journal Article] Ca^<2+> overload and sarcoplasmic reticulum instability in tric-a null skeletal muscle.2010
- Author(s)
 Zhao, X., Yamazaki, D., Park, K-H., Komazaki, S., Tjondrokoesoemo, A., Nishi, M., Lin, P., Hirata, Y., Brotto, M., Takeshima, H., Ma, J.
- Journal Title
 
 J.Biol.Chem. 285
 
 Pages: 37370-37376
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-20249004
[Journal Article] Charade of the SR K^+-channel : two ion-channels, TRIC-A and TRIC-B, masquerade as a single K^+-channel.2010
- Author(s)
  Pitt, S.J., Park, K-H., Nishi, M., Urashima, T., Aoki, S., Yamazaki, D., Ma, J., Takeshima, H., Sitsapesan, R.
- Journal Title
  
  Biophys.J. 99
  
  Pages: 417-426
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249004
[Journal Article] Imparied Orai1-mediateded resting Ca2+ entry reduces the cytosolic[Ca2+] and SR Ca2+ loading in quitescent junctophilin1 knockout myotubes2010
- Author(s)
  Li, H., Ding, X., Lopez, J. R., Takeshima, H., Ma, J., Allen, P. D. & Eltit, J. M.
- Journal Title
  
  J. Biol. Chem
  
  Volume: 285 Issue: 50 Pages: 39171-39179
- DOI
  10.1074/jbc.m110.149690
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659066
[Journal Article] Mitsugumin 23 forms massive bowl-shaped assembly and cation-selective channel.2010
- Author(s)
  Venturi E, Mio K, Nishi M, Ogura T, Moriya T, Okuda K, Kakizawa S, Sitapeasan R, Sato C., Takeshima H
- Journal Title
  
  Biochemistry
  
  Volume: 50(印刷中) Pages: 2623-2632
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249004
[Journal Article] Mitsugumin 53-mediated maintenance of K+ currents in cardiac myocytes.2009
- Author(s)
  Masumiya.H., Asaumi. Y., Nishi, M., Minamisawa.S., Adachi. Akahane. S., Yoshida, M., Kangawa, K., Ito, K., Kagaya, Y., Yanagisawa, T., Yamazaki, T., Ma, J., Takeshima, H.
- Journal Title
  
  Channels 3
  
  Pages: 6-11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17081001
[Journal Article] Membrane repair defects in muscular dystrophy are linked to altered interaction between MG53, caveolon-3 and2009
- Author(s)
  Cai, C., Weisleder.N., Ko, J.K., Komazaki, S.,Sunada. Y.,Nishi.M., Takeshima, H, Ma.J.
- Journal Title
  
  J.Biol.Chem. 284
  
  Pages: 15894-15902
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17081001
[Journal Article] MG53 nucleates assembly of cell membrane repair machinery2009
- Author(s)
  Cai, C., Masumiya, H., Weisleder, N., Matsuda, N., Nishi, Hwang, M., Ko, J-K., Lin, P., Thornton, A., Zhao, X. , Pan, Z., Komazaki, S., Brotto, M., Takeshima, H. & Ma, J.
- Journal Title
  
  Nature Cell Biol. 11
  
  Pages: 56-64
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17081001
[Journal Article] Essential role of TRIC-B channel in Ca^<2+>- handling of alveolar epithelium and perinatal lung maturation.2009
- Author(s)
 Yamazaki, D., Komazaki, S., Nakanishi, H., Mishima, A., Nishi, M., Yazawa, M., Yamazaki, T., Taguchi, R., Takeshima, H.
- Journal Title
 
 Development 136
 
 Pages: 2355-2361
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-20249004
[Journal Article] MG53 regulates membrane budding and exocytosis in muscle cells2009
- Author(s)
  Cai, C., Masumiya, H., Weisleder, N., Pan, Z., Nishi, M., Ko, J-K., Komazaki, S., Takeshima, H. & and Ma, J.
- Journal Title
  
  J. Biol. Chem 284
  
  Pages: 3314-3322
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17081001
[Journal Article] Essential role of TRIC-B channel in Ca2+ handling of alveolar epithelium and perinatal lung maturation.2009
- Author(s)
  Yamazaki, D., Komazaki, S., Nakanishi, H., Mishima, A., Nishi, M., Yazawa, M., Yamazaki, T., Taguchi, R., Takeshima, H.
- Journal Title
  
  Development 136
  
  Pages: 2355-2361
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249004
[Journal Article] MG53 nucleates assembly of cell membrane repair machinery.2009
- Author(s)
  Cai, C., Masumiya, H., Weisleder, N., Matsuda, N., Nishi, M., Hwang, M., Ko, J-K., Lin, P., Thornton, A., Zhao, X., Pan, Z., Komazaki, S., Brotto, M., Takeshima, H.^*, Ma, J.^* (*^co-corresponding authors)
- Journal Title
  
  Nature Cell Biol. 11
  
  Pages: 56-64
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249004
[Journal Article] (co-corresponding authors) MG53 nucleates assembly of cell membrane repair machinery.2009
- Author(s)
  Cai C, Masumiya H, Weisleder N, Matsuda N, Nishi M, Hwang M, Ko J-K, Lin P, Thornton A, Zhao X, Pan Z, Komazaki S, Brotto M, Takeshima H, Ma J.
- Journal Title
  
  Nature Cell Biol. 11
  
  Pages: 56-64
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17081015
[Journal Article] Mitsugumin 53-mediated maintenance of K^+ currents in cardiac myocytes.2009
- Author(s)
  Masumiya, H., Asaumi, Y., Nishi, M., Minamisawa, S., Adachi-Akahane, S., Yoshida, M., Kangawa, K., Ito, K., Kagaya, Y., Yanagisawa, T., Yamazaki, T., Ma, J., Takeshima, H.
- Journal Title
  
  Channels 3
  
  Pages: 6-11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249004
[Journal Article] MG53 regulates membrane budding and exocytosis in muscle cells.2009
- Author(s)
  Cai, C., Masumiya, H., Weisleder, N., Pan, Z., Nishi, M., Ko, J-K., Komazaki, S., Takeshima, H.^*, Ma, J.^* (*^co-corresponding authors)
- Journal Title
  
  J.Biol.Chem. 284
  
  Pages: 3314-3322
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249004
[Journal Article] (*co-corresponding authors) MG53 nucleates assembly of cell membrane repair machinery.2009
- Author(s)
  Cai, C., Masumiya, H., Weisleder, N., Matsuda, N., Nishi, M., Hwang, M., Ko, J-K., Lin, P., Thornton, A., Zhao, X., Pan, Z., Komazaki, S., Brotto, M., Takeshima, H.*, Ma, J.*
- Journal Title
  
  Nature Cell Biol. 11
  
  Pages: 56-64
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17081001
[Journal Article] Essential role of TRIC-B channel in Ca^<2+>-handling of alveolar epithelium and perinatal lung maturation.2009
- Author(s)
 Yamazaki, D., Komazaki, S., Nakanishi, H., Mishima, A., Nishi, M., Yazawa, M., Yamazaki, T., Taguchi, R., Takeshima, H.
- Journal Title
 
 Development 136
 
 Pages: 2355-2361
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-17081001
[Journal Article] MG53 nucleates assembly of cell membrane repair machinery.2009
- Author(s)
  Cai, C., Masumiya, H., Weisleder, N., Matsuda, N., Nishi, M., Hwang, M., Ko, J-K., Lin, P., Thornton, A., Zhao, X., Pan, Z., Komazaki, S., Brotto, M., Takeshima, H., Ma, J
- Journal Title
  
  Nature Cell Biol. 11
  
  Pages: 56-64
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249004
[Journal Article] Genetic evidence for functional role of ryanodine receptor 1 in pulmonary artery smooth muscle cells2009
- Author(s)
  Li XQ, Zheng YM, Rathore R, Ma J. Takeshima H., et.al.
- Journal Title
  
  Pflugers Arch 457
  
  Pages: 771-783
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17081015
[Journal Article] Sarcalumenin is essential for maintaining cardiac function during endurance exercise training.2009
- Author(s)
  Jiao,Q., Bai, Y., Akaike, T., Takeshima,H., Ishikawa, Y., et al.
- Journal Title
  
  Am.J.Physiol.Heart Circ.Physiol. 297
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17081015
[Journal Article] Genetic evidence for functional role of ryanodine receptor 1 in pulmonary artery smooth muscle cells2009
- Author(s)
  Li, X. Q., Zheng, Y. M., Rathore, R., Ha, J., Takeshima, H. & Wang, Y. X
- Journal Title
  
  Pflugers Arch. 457
  
  Pages: 771-783
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17081001
[Journal Article] New molecular components supporting ryanodine receptor-mediated Ca2+ release : roles of junctophilin and TRIC2008
- Author(s)
  Yamazaki, T., Yamazaki, D., Takeshima, H.
- Journal Title
  
  Pharmacol. Ther. 121
  
  Pages: 265-272
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249004
[Journal Article] TRPM2-mediated Ca2+ influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration.2008
- Author(s)
  Y amamoto S, Shimizu S, Kiyonaka S, Takahashi N, Wajima T, Hara Y, Negoro T, Hiroi T, Kiuchi Y, Okada T, Kaneko S, Lange I, Fleig A, Penner R, Nishi M, Takeshima H, Mori Y.
- Journal Title
  
  Nature Med. 14
  
  Pages: 738-747
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17081015
[Journal Article] Nociceptin-receptor deficiency prevents postherpetic pain without effects on acute herpetic pain in mice2008
- Author(s)
  Sasaki A, Takasaki I, Andoh T, Shiraki K, Takeshima H, et.al.
- Journal Title
  
  Neuroreport 19
  
  Pages: 83-86
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17081015
[Journal Article] Sarcalumenin alleviates stress-induced cardiac dysfunction by improving Ca^<2+> handling of the sarcoplasmic reticulum.2008
- Author(s)
 Shimura, M., Minamisawa, S., Takeshima, H., Jiao, Q., Bai, Y., Umemura, S., Ishikawa, Y.
- Journal Title
 
 Cardiovasc. Res. 77
 
 Pages: 362-370
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-20249004
[Journal Article] Single-channel characterization of the rabbit recombinant RyR2 reveals a novel inactivation property of physiological concentrations of ATP.2008
- Author(s)
  Stewart, R., Song, L., Carter, S.M., Sigalas, C., Zaccai, N.R., Kanamarlapudi, V., Bhat, M.B., Takeshima, H., Sitsapesan, R.
- Journal Title
  
  J. Membr. Biol. 222
  
  Pages: 65-77
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17081001
[Journal Article] TRPM2-mediated Ca^<2+> influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration.2008
- Author(s)
 Yamamoto, S., Shimizu, S., Kiyonaka, S., Takahashi, N., Wajima, T., Hara, Y., Negoro, T., Hiroi, T., Kiuchi, Y., Okada, T., Kaneko, S., Lange, I., Fleig, A., Penner, R., Nishi, M., Takeshima, H, Mori, Y.
- Journal Title
 
 Nature Med. 14
 
 Pages: 738-747
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-20249004
[Journal Article] Single-channel characterization of the rabbit recombinant RyR2 reveals a novel inactivation property of physiological concentrations of ATP.2008
- Author(s)
  Stewart, R., Song, L., Carter, S.M., Sigalas, C., Zaccai, N.R., Kanamarlapudi, V., Bhat, M.B., Takeshima, H., Sitsapesan, R.
- Journal Title
  
  J.Membr.Biol. 222
  
  Pages: 65-77
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249004
[Journal Article] Functional crosstalk between cell-surface and intracellular channels mediated by junctophilins essential for neuronal functions2008
- Author(s)
  Kakizawa S, Moriguchi S, Ikeda A, Iino M, Takeshima H.
- Journal Title
  
  Cerebellum 7
  
  Pages: 385-361
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17081015
[Journal Article] Single-channel characterization of the rabbit recombinant RyR2 reveals a novel inactivation property of physiological concentrations of ATP2008
- Author(s)
  Stewart, R., Song, L., Carter, S. M., Sigalas, C., Zaccai, N. R., Kanamarlapudi, V., Bhat, M. B., Takeshima, H., Sitsapesan, R.
- Journal Title
  
  J. Membr. Biol. 222
  
  Pages: 65-77
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249004
[Journal Article] Superoxide-induced potentiation in the hippocampus requires activation of ryanodine receptor type 3 and ERK2008
- Author(s)
  Huddleston AT, Tang W, Takeshima H, Hamilton SL, et.al.
- Journal Title
  
  J. Neurophysiol 99
  
  Pages: 1565-1571
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17081015
[Journal Article] Ryanodine receptor type 2 deficiency changes excitation-contraction coupling and membrane potential in urinary bladdersmooth muscle.2007
- Author(s)
  Hotta, S.・Morimura, K.・Ohya, S.・Muraki, K.・Takeshima, H.・Imaizumi, Y.
- Journal Title
  
  J Physiol 582
  
  Pages: 489-506
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17081015
[Journal Article] Mg2+ activates the ryanodine receptor type 2 (RyR2) at intermediate Ca2+ concentrations.2007
- Author(s)
  Chugun, A・Sato, O・Takeshima, H・Ogawa, Y
- Journal Title
  
  Am J Cell Phys 292
  
  Pages: 535-544
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17081015
[Journal Article] ORL1 receptor-mediated down-regulation of mRER2 in the suprachiasmatic nucleus accelerates re-entrainment of the circadian clock following a shift in the environmental light/dark cycle.2007
- Author(s)
  Miyakawa, K・Uchida, A・Shiraki, T・Tesjo,a, K・Takeshima, H, et. al.
- Journal Title
  
  Neuropharmacol 52
  
  Pages: 1055-1064
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17081015
[Journal Article] Mutations of junctophilin type 2 associated with hypertrophic cardiomyopathy.2007
- Author(s)
  Matsushita, Y., Furukawa, T., Kasanuki, H., Nishibatake, M., Kurihara, Y., Ikeda, A., Kamatani, N., Takeshima, H., Matsuoka, R.
- Journal Title
  
  J. Hum. Genet. 52
  
  Pages: 543-548
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17081001
[Journal Article] Junctophilin-mediated channel crosstalk essential for cerebellar synaptic plasticity.2007
- Author(s)
  Kakizawa, S., Kishimoto, Y., Hashimoto, K., Miyazaki, T., Furutani, K., Shimizu, H., Fukaya, M., Nishi, M., Sakagami, H., Ikeda, A., Kondo, H., Kano, M., Watanabe, M., Iino, M., Takeshima, H.
- Journal Title
  
  EMBO J. 26
  
  Pages: 1924-1933
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17081001
[Journal Article] Conformation-dependent staility of junctophilin 1(JP1) and ryanodine receptor type 1 (RyR1) channel complex is mediated by their hyper-reactive thiols.2007
- Author(s)
  Phimister, A.J.・Lango, J.・Lee., E.H.・Ernst-Russell, M.・Takeshima, H.・Ma, J.・Allen, P.D.・Pessah, I.N
- Journal Title
  
  J. Biol. Chem 282
  
  Pages: 8667-8677
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17081015
[Journal Article] TRIC channels are essential for Ca^<2+> handling in intracellular stores2007
- Author(s)
 Yazawa, M., Ferrante, C., Feng, J., Mio, K., Ogura, T., Zhang, M., Lin, P-H., Pan, Z., Komazaki, S., Kato, K., Nishi, M., Zhao, X., Weisleder, N., Sato, C., Ma, J., Takeshima, H
- Journal Title
 
 Nature 448
 
 Pages: 78-82
- Description
 「研究成果報告書概要(欧文)」より
- Data Source
 KAKENHI-PROJECT-15109005
[Journal Article] Abnormal features in mutant cerebellar Purkinje cells lacking junctophilins.2007
- Author(s)
  Ikeda, A., Miyazaki, T., Kakizawac, S., Okuno, Y., Tsuchiya, S., Myomoto, A., Saito, S., Yamamoto, T., Yamazaki, T., Iino, M., Tsujimoto, G., Watanabe, M., Takeshima, H.
- Journal Title
  
  Biochem. Biophys. Res. Commun. 363
  
  Pages: 835-839
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17081001
[Journal Article] Calumin, a novel Ca^<2+>-binding transmembrane protein on the endoplasmic reticulum.2007
- Author(s)
 Zhang, M., Yamazaki, T., Yazawa, M., Treves, S., Nishi, M., Murai, M., Shibata, E., Zorzato, F., Takeshima, H.
- Journal Title
 
 Cell Calcium 42
 
 Pages: 83-90
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-17081001
[Journal Article] Junctophilin-mediated channel crosstalk essential for cerebellar synaptic plasticity.2007
- Author(s)
  Kakizawa S, Kishimoto Y, Hashimoto K, Miyazaki T, Furutani K, Shimizu H, Fukaya M, Nishi M, Sakagami H, Ikeda A, Kondo H, Kano M, Watanabe M, Iino M, Takeshima H.
- Journal Title
  
  EMBO J. 26
  
  Pages: 1924-1933
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17081015
[Journal Article] Calumin, a novel Ca2+-binding transmembrane protein on the endoplasmic reticulum.2007
- Author(s)
  Zhang M, Yamazaki T, Yazawa M, Treves S, Nishi M, Murai M, Shibata E, Zorzato F, Takeshima H.
- Journal Title
  
  Cell Calcium. 42
  
  Pages: 83-90
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17081015
[Journal Article] Calumin, a novel Ca^<2+>-binding transmembrane protein on the endoplasmic reticulum2007
- Author(s)
 Zhang, M., Yamazaki, T., Yazawa, M., Treves, S., Nishi, M., Muni, M., Shibata, E., Zorzato, F., Takeshima, H
- Journal Title
 
 Cell Calcium 42
 
 Pages: 83-90
- Description
 「研究成果報告書概要(欧文)」より
- Data Source
 KAKENHI-PROJECT-15109005
[Journal Article] Nociceptin receptor (NOP)-deficient mice show memory and learning enhancement in a novel KUROBOX apparatus using stress-free positive cue task.2007
- Author(s)
  Nagai, J.・Kurokawa, M.・Takeshima, H.・Kieffer, B.・L. Ueda, H
- Journal Title
  
  J. Pharmacol. Exp. Ther. 321
  
  Pages: 195-201
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17081015
[Journal Article] TRIC channels are essential for Ca^<2+> handling in intracellular stores.2007
- Author(s)
 Yazawa, M., Ferrante, C., Feng, J., Mio, K., Ogura, T., Zhang, M., Lin, P-H., Pan, Z., Komazaki, S., Kato, K., Nishi, M., Zhao, X., Weisleder, N., Sato, C., Ma, J., Takeshima, H.
- Journal Title
 
 Nature 448
 
 Pages: 78-82
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-17081001
[Journal Article] Systemic ablation of RyR3 Ca2+ spark signaling in adult skeletal muscle.2007
- Author(s)
  Weisleder, N.・Ferrante, C.・Hirata, Y.・Collet, C.・Chu, Y.・Cheng, H.・Takeshima, H.・Ma, J
- Journal Title
  
  Cell Calcium 42
  
  Pages: 548-555
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17081015
[Journal Article] TRIC channels are essential for Ca2+ handling in intracellular stores.2007
- Author(s)
  Yazawa M, Ferrante C, Feng J, Mio K, Ogura T, Zhang M, Lin P-H, Pan Z, Komazaki S, Kato K, Nishi M, Zhao X, Weisleder N, Sato C, Ma J, Takeshima H.
- Journal Title
  
  Nature. 448
  
  Pages: 78-82
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17081015
[Journal Article] Abnormal features in mutant cerebellar Purkinje cells lacking junctophilins2007
- Author(s)
  Ikeda, A., Miyazaki, T., Kakizawac, S., Okuno, Y., Tsuchiya, S., Myomoto, A., Saito, S., Yamamoto, T., Yamazaki, T., lino, M., Tsujimoto, G., Watanabe, M., Takeshima, H
- Journal Title
  
  Biochem. Biophys. Res. Commun 363
  
  Pages: 835-839
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15109005
[Journal Article] Functional uncoupling between Ca2+ release and afterhyperpolarization in mutant hippocampal neurons lacking junctophilins.2006
- Author(s)
  Moriguchi S, Nishi M, Komazaki S, Sakagami H, Miyazaki T, Masumiya H, Saito S, Watanabe M, Kondo H, Yawo H, Fukunaga K, Takeshima H.
- Journal Title
  
  Proc.Natl.Acad.Sci.USA. 103
  
  Pages: 10811-10816
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17081015
[Journal Article] Uncoupling of store-operated Ca^<2+> entry and altered Ca^<2+> release from sarcoplasmic reticulum through silencing of junctophilins.2006
- Author(s)
 Hirata, Y., Brotto, M., Weisleder, N., Chu, Y., Lin, P., Zhao, X., Thornton, A., Komazaki, S., Takeshima, H., Ma, J., Pan, Z.
- Journal Title
 
 Biophys. J. 90
 
 Pages: 4418-4427
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-17081001
[Journal Article] Functional uncoupling between Ca^<2+> release and afterhyperpolarization in mutant hippocampal neurons lacking junctophilins.2006
- Author(s)
 Moriguchi, S., Nishi, M., Komazaki, S., Sakagami, H., Miyazaki, T., Masumiya, H., Saito, S., Watanabe, M., Kondo, H., Yawo, H., Fukunaga, K., Takeshima, H.
- Journal Title
 
 Proc. Natl. Acad. Sci. USA 103
 
 Pages: 10811-10816
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-17081001
[Journal Article] Impaired cerebellar functions in mutant mice lacking DNER.2006
- Author(s)
  Togho A, Eiraku M, Miyazaki T, Miura E, Kawaguchi S, Nishi M, Watanabe M, Hirano T, Kengaku M, Takeshima H.
- Journal Title
  
  Mol.Cell.Neurosci. 31
  
  Pages: 326-333
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17081015
[Journal Article] Muscle aging is associated with compromised Ca2+ spark signaling and segregated intracellular Ca2+ release.2006
- Author(s)
  Weisleder N, Brotto M, Komazaki S, Pan Z, Zhao X, Nosek T, Parness J, Takeshima H, Ma J.
- Journal Title
  
  J.Cell Biol. 174
  
  Pages: 639-645
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17081015
[Journal Article] Impaired Ca2+ store functions in skeletal and cardiac muscle cells from sarcalumenin-deficient mice.2005
- Author(s)
  Yoshida M, Minamisawa S, Komazaki S, Shimura M, Kume H, Zhang M, Matsumura K, Nishi M, Saito M, Ishikawa Y, Yanagisawa T, Takeshima H.
- Journal Title
  
  J.Biol.Chem. 280
  
  Pages: 3500-3506
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17081015
[Journal Article] Junctophilin type 2 is associated with caveolin-3 and is down-regulated in the hypertrophic and dilated cardiomyopathies.2004
- Author(s)
  Minamisawa S, Oshikawa J, Takeshima H, Hoshijima M, Wang Y, Chien KR, Ishikawa Y, Matsuoka R
- Journal Title
  
  Biochem.Biophys.Res.Commun. 325
  
  Pages: 852-856
- Data Source
  KAKENHI-PROJECT-12144210
[Journal Article] Exogenous, but not endogenous nociceptin modulates mesolimbic dopamine release in mice.2004
- Author(s)
  Koizumi M, Midorikawa N, Takeshima H, Murphy NP.
- Journal Title
  
  J Neurochem. 89
  
  Pages: 257-263
- Data Source
  KAKENHI-PROJECT-12144210
[Journal Article] Co-expression of mg29 and ryanodine receptor leads to apoptotic cell death-effect mediated by intracellular Ca^<2+> release.2004
- Author(s)
 Pan Z, Hirata Y, Nagaraj RY, Zhao J, Nishi M, Hayek SM, Bhat MB, Takeshima H, Ma J.
- Journal Title
 
 J.Biol.Chem. 279
 
 Pages: 19387-19390
- Data Source
 KAKENHI-PROJECT-12144210
[Journal Article] Lack of nociceptin receptor alters body temperature during the resting period m mice.2004
- Author(s)
  Uezu K, Sei H, Sano A, Toida K, Suzuki-Yamamoto T, Houtani T, Sugimoto T, Takeshima H., Ishimura K, Morita Y.
- Journal Title
  
  Neuroneport 15
  
  Pages: 751-755
- Data Source
  KAKENHI-PROJECT-12144210
[Journal Article] Defective maintenance of intracellular Ca^<2+> homeostasis is linked to increased muscle fatigability in the MG29 null mice.2004
- Author(s)
 Brotto MA, Nagaraj RY, Brotto LS, Takeshima H, Ma J, Nosek TM.
- Journal Title
 
 Cell Res. 14
 
 Pages: 373-378
- Data Source
 KAKENHI-PROJECT-12144210
[Journal Article] Identification and characterization of a novel Rho GTPase activating protein implicated in receptor-mediated endocytosis.2004
- Author(s)
  Sakakibara T, Nemoto Y, Nukiwa T, Takeshima H.
- Journal Title
  
  FEBS Lett. 566
  
  Pages: 294-300
- Data Source
  KAKENHI-PROJECT-12144210
[Journal Article] Intradermal nociceptin elicits itch-associated responses through leukotriene B4 in mice2004
- Author(s)
  Andoh T, Yageta Y, Takeshima H, Kuraishi Y.
- Journal Title
  
  J.Invest.Dermatol. 123
  
  Pages: 196-201
- Data Source
  KAKENHI-PROJECT-12144210
[Journal Article] Junctophilins : a novel family of junctional membrane complex proteins.2000
- Author(s)
  Takeshima H, et al.
- Journal Title
  
  Mol.Cell 6
  
  Pages: 11-22
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12144210
[Journal Article] Junctophilins : a novel family of junctional membrane complex proteins.2000
- Author(s)
  Takeshima H, et al.
- Journal Title
  
  Mol. Cell 6
  
  Pages: 11-22
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12144210
[Journal Article] Impaired Ca^<2+> store functions in skeletal and cardiac muscle cells from sarcalumenin-deficient mice.
- Author(s)
 Yoshida M, Minamisawa S, et al. Yanagisawa T, Takeshima H.
- Journal Title
 
 J.Biol.Chem. (in press)
- Data Source
 KAKENHI-PROJECT-12144210
[Presentation] Contribution of Mitsugumin 23 to Ca2+ leakage of sarcoplasmic reticulum in skeletal muscle fibers2023
- Author(s)
 Watanabe Daiki、Nishi Miyuki、Liu Feng、Takeshima Hiroshi
- Organizer
 Gordon Research Conference Muscle: Excitation-contraction coupling
- Int'l Joint Research
- Data Source
 KAKENHI-PROJECT-23K24738
[Presentation] Role of Mitsugumin 23 in Ca2+ storage of sarcoplasmic reticulum in type I and type II fibers of the mice2023
- Author(s)
 Watanabe Daiki、Nishi Miyuki、Liu Feng、Takeshima Hiroshi
- Organizer
 50th European Muscle Conference
- Int'l Joint Research
- Data Source
 KAKENHI-PROJECT-23K24738
[Presentation] ミツグミン23が骨格筋疲労に及ぼす影響2022
- Author(s)
  渡邊大輝，西美幸，竹島浩
- Organizer
  第8回日本筋学会
- Data Source
  KAKENHI-PROJECT-23K24738
[Presentation] 心臓におけるTRIC-Aの機能2021
- Author(s)
  竹島浩
- Organizer
  日本生理学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02597
[Presentation] Intracellular TRIC channels: electrophysiological and pathophysiological characterization.2017
- Author(s)
  Takeshima H.
- Organizer
  Gordon Research Conference; Organellar channels & transporters
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04676
[Presentation] TRIC channels are essential partners for Ca^<2+> release2012
- Author(s)
 Takeshima, H
- Organizer
 European Calcium Channel Conference
- Place of Presentation
 Alpbach, Austria
- Year and Date
 2012-05-19
- Data Source
 KAKENHI-PROJECT-23240055
[Presentation] TRIC channels supporting physiological Ca^<2+> release2012
- Author(s)
 Takeshima, H
- Organizer
 Gordon Research Conference; muscle E-C coupling
- Place of Presentation
 Les Diablerets, Switzerland
- Year and Date
 2012-06-04
- Data Source
 KAKENHI-PROJECT-23240055
[Presentation] TRIC channel subtypes, willing partners with Ca^<2+> release channels in intracellular stores2011
- Author(s)
 Takeshima, H
- Organizer
 Gordon Research Conference; Ca^<2+> signaling
- Place of Presentation
 Waterville Valley, USA
- Year and Date
 2011-06-27
- Data Source
 KAKENHI-PROJECT-23240055
[Presentation] TRIC channel subtypes, willing partners with Ca2+ release channels in intracellular stores2011
- Author(s)
  Takeshima, H.
- Organizer
  Gordon Research Conference ; Ca2+ signaling
- Place of Presentation
  Watervilie Valley, USA(招待講演)
- Year and Date
  2011-06-27
- Data Source
  KAKENHI-PROJECT-23240055
[Presentation] Immuno-proteomic approach to E-C coupling : junctophilin and TRIC channel in cardiac Ca^<2+> release2010
- Author(s)
 Takeshima, H.
- Organizer
 IUPS satellite symposium
- Place of Presentation
 ホテルフジタ(京都)
- Year and Date
 2010-07-28
- Data Source
 KAKENHI-PROJECT-20249004
[Presentation] TRIC channel subtypes and SR/ER Ca^<2+> release.2009
- Author(s)
 Takeshima, H.
- Organizer
 Gordon Research Conference; Muscle Excitation-Contraction Coupling
- Place of Presentation
 in Waterville Valley, USA
- Year and Date
 2009-06-18
- Data Source
 KAKENHI-PROJECT-17081001
[Presentation] Immuno-proteomic approach to E-C coupling : junctophilin and TRIC channel in cardiac Ca2+ release2009
- Author(s)
  Takeshima H.
- Organizer
  IUPS Whole-day Symposium.
- Place of Presentation
  Kyoto.
- Year and Date
  2009-07-28
- Data Source
  KAKENHI-PROJECT-17081015
[Presentation] Molecular components supporting ryanodine receptor-mediated Ca^<2+> release : roles of junctophilin and TRIC channel in cardiac Ca^<2+> release."2009
- Author(s)
 Takeshima, H.
- Organizer
 JST Japan-Mexico Scientific Workshop
- Place of Presentation
 in Universidad Nacional Autonoma de Mexico (UNAM), Mexico City
- Year and Date
 2009-02-25
- Data Source
 KAKENHI-PROJECT-20249004
[Presentation] Immuno-proteomic approach to E-C coupling: junctophilin and TRIC channel in cardiac Ca^<2+> release2009
- Author(s)
 Takeshima, H.
- Organizer
 IUPS Whole-day Symposium
- Place of Presentation
 in Kyoto
- Year and Date
 2009-07-28
- Data Source
 KAKENHI-PROJECT-17081001
[Presentation] TRIC channel subtypes and SR/ER Ca^<2+> release. Gordon Research Conference.2009
- Author(s)
 Takeshima, H.
- Organizer
 Muscle Excitation-Contraction Coupling
- Place of Presentation
 in Waterville Valley, USA.
- Year and Date
 2009-06-18
- Data Source
 KAKENHI-PROJECT-20249004
[Presentation] TRIC channel subtypes and SR/ER Ca2+ release.2009
- Author(s)
  Hiroshi Takeshima
- Organizer
  Gordon Research Conference ; Muscle Excitation-Contraction Coupling.
- Place of Presentation
  Waterville Valley, USA.
- Year and Date
  2009-06-18
- Data Source
  KAKENHI-PROJECT-20249004
[Presentation] Ryanodine receptor-mediated Ca2+ release from muscle sarcoplasmic reticulum2006
- Author(s)
  Takeshima H.
- Organizer
  Gordon Research Conference ; Muscle Excitation-Contraction Coupling.
- Place of Presentation
  New London, USA.
- Year and Date
  2006-06-09
- Data Source
  KAKENHI-PROJECT-17081015
[Presentation] Ryanodine receptor-mediated Ca^<2+> release from sarcoplasmic reticulum2006
- Author(s)
 Takeshima, H.
- Organizer
 Gordon Research Conference; Muscle Excitation-Contraction Coupling
- Place of Presentation
 in New London, USA
- Year and Date
 2006-06-09
- Data Source
 KAKENHI-PROJECT-17081001
[Presentation] Mitsugumins, a series of novel membrane proteins in skeletal muscle2006
- Author(s)
  Takeshima, H.
- Organizer
  Muscle Symposium in Basel
- Place of Presentation
  in Basel, Switzerland
- Year and Date
  2006-05-05
- Data Source
  KAKENHI-PROJECT-17081001
[Presentation] Junctophilin-mediated channel coupling during muscle E-C coupling2005
- Author(s)
  Takeshima, H.
- Organizer
  European Muscle Conference
- Place of Presentation
  in Debrecen, Hungary
- Year and Date
  2005-09-17
- Data Source
  KAKENHI-PROJECT-17081001
[Presentation] TRIC channels supporting physiological Ca2+ release.
- Author(s)
  Hiroshi Takeshima
- Organizer
  Gordon Research Conference; muscle E-C coupling
- Place of Presentation
  Les Diablerets, Switzerland
- Invited
- Data Source
  KAKENHI-PROJECT-23240055
[Presentation] TRIC channels and vascular tonus
- Author(s)
  Takeshima, H.
- Organizer
  Gordon Research Conference; Ca2+ signaling
- Place of Presentation
  Tuscany Il Ciocco Resorts, Lucca, Italy
- Data Source
  KAKENHI-PROJECT-23240055

1. 竹島美幸 (60183894)

# of Collaborated Projects: 4 results

# of Collaborated Products: 29 results
2. Murakami Manabu (80302090)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
3. 東郷暁 (40282123)

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4. MORI Yasuo (80212265)

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5. ENDO Makoto (50009990)

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6. IKEMOTO Takaaki (30275854)

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7. 飯野正光 (50133939)

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8. 伊藤公一 (50330874)

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12. 丹羽康貴 (40590071)

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13. KANAI Yoshikatsu (60204533)

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14. SUZUKI Hiroshi (80206523)

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15. KURAMOCHI Tomoya (10186497)

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16. NUMA Shosaku (50025516)

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17. FUJITA Yoshihiko (80192730)

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18. FUKUDA Kazuhiko (90199224)

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19. TANABE Tsutomu (70183069)

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20. IMOTO Keiji (00176512)

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21. Itoh Hideki (30402738)

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23. 桑木共之 (80205260)

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24. 山澤徳志子 (00282616)

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25. 廣瀬謙造 (00292730)

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29. 真鍋俊也 (70251212)

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32. 加藤浩一 (70736983)

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34. 渡邊大輝 (30823281)

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35. 和田正信 (80220961)

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37. 長友克広 (30542568)

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38. 村上アグニェシュカ (60859742)

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39. OHTA Hisashi

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40. 岩沢善一

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41. ICHIMURA Atsuhiko

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42. FUJII Takuto

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43. 清水貴浩

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45. 植田洋平

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Takeshima Hiroshi 竹島 浩

TAKESHIMA Hiroshi 竹島 浩

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TRIC and MG23 channels in store Ca2+ handlingPrincipal Investigator

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Study on TRIC and MG23 channelsPrincipal Investigator

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Study on TRIC channel and MG56Principal Investigator

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Vesicular dynamics in parietal and muscle cellsPrincipal Investigator

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Counter ion movement during Ca2+ releasePrincipal Investigator

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Study of TRIC and MG23 channelsPrincipal Investigator

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Identification of muscular senescence-related genesPrincipal Investigator

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Roles of novel intracellular ion channelsPrincipal Investigator

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Channel micro-assembly in junctional membrane complexesPrincipal Investigator

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Takeshima Hiroshi 竹島浩

TAKESHIMA Hiroshi 竹島浩