Yanase Mikio 柳瀬幹雄

… Alternative Names

YANASE Mikio 柳瀬幹雄

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Researcher Number	50334397
Affiliation (Current)	2023: 国立研究開発法人国立国際医療研究センター, その他部局等, その他
Affiliation (based on the past Project Information) *help	2002 – 2006: The University of Tokyo, Faculty of Medicine, Research Associate, 医学部附属病院, 助手 2001: The UNIV. OF TOKYO, FACULTY OF MEDICINE, INSTRUCTOR, 医学部・附属病院, 助手
Review Section/Research Field	Principal Investigator Gastroenterology Except Principal Investigator Gastroenterology / Gastroenterology
Keywords	Principal Investigator Lysophosphatidic acid / 肝星細胞 / Autotaxin / Lipid phosphate phosphohydrolase / 低分子量G淡白質Rho / 肝細胞 / Lysophospholipase D / Auto taxin / LYSOPHOSHATIDIC ACID / HEPATIC STELLATE CELLS / AUTOTAXIN / LIPID PHOSPHATE PHOSPHOHYDROLASE … More Except Principal Investigator … More HGF / リゾフォスファチジン酸 / スフィンゴシン1リン酸 / 肝細胞 / TGFα / Hepatocytes / Edg-5(S1P_2) / Rho / 虚血再灌流障害 / Leucine / Ischemic preconditioning / NADPH oxidase / 門脈圧亢進症 / 星細胞 / スフィンゴシンコリン酸 / PORTAL HYPERTENSION / HEPATIC STELLATE CELLS / SPHINGOSINE 1-PHOSPHATE / LYSOPHOSPHATIDIC ACID / 増殖 / 機能 / proliferation / functions / 肝再生 / EDG5 / sphingosine 1-phosphate / liver regeneration / ischemic preconditioning / 肝移植 / 虚血再潅流障害 / ISCHEMIA / REPERFUSION INJURY / ISCHEMIC PRECONDITIONING / LIVER TRANSPLANTATION / ロイシン / Kupffer細胞 / 活性酸素 / 酸化ストレス / 移植・再生医療 / reactive oxygen species(ROS) / Ischemia / reperfusion injury / Kupffer cells / Oxygen radicals / Oxidative stress / Transplantation and regeneration / オートタキシン / 肝線維化 / 肝硬変 / 肝障害 / Autotaxin / Lysophosphatidic acid / Liver fibrosis / Liver cirrhosis / Liver damage / 再生医学 / 栄養学 / トランスレイショナルリサーチ / 生理活性 / トランスレイショナルリサー / Regenerative medicine / Nutrition / Translational research / Bioactivity Less

Modulation by amino acids of the expression of factors produced by hepatic stellate cells : its implication in injured liver
- Principal Investigator
  
  TOMIYA Tomoaki
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
Research for mechanisms of induction of hepatic ischemic tolerance by ischemic preconditioning.
- Principal Investigator
  
  TEJIMA Kazuaki
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
Elucidation of the clinical significance of autotaxin and lysophosphatidic acid in liver diseases.
- Principal Investigator
  
  IKEDA Hitoshi
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
Induction of hepatocyte growth factor by physiological agents : its effects on hepatocyte proliferation and protein production
- Principal Investigator
  
  TOMIYA Tomoaki
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
Functional Analysis of The Biological Activities of a Lipid Mediator, Lysophoshatidie Acid, on The Pathogenesis of Liver FibrosisPrincipal Investigator
- Principal Investigator
  
  YANASE Mikio
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
Elucidation of the mechanism of the inhibitory effect of sphingosine 1-phosphate on hepatocyte proliferation and the significance in liver regeneration
- Principal Investigator
  
  IKEDA Hitoshi
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
LIVER PROTECTION AGAINST ISCHEMIAJREPERFUSION INJURY BY ISCHEMIC PRECONDITIONING
- Principal Investigator
  
  ARAI Masahiro
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  THE UNIVERSITY OF TOKYO
Significance of growth factors for Hepatocyte proliferation and functions
- Principal Investigator
  
  TOMIYA Tomoaki
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
PORTAL HYPERTENSION-ELUCIDATION OF THE MECHANISM IN THE LIGHT OF FUNCTIONAL ABNORMALITIES OF HEPATIC STELLATE CELLS AND DEVELOPMENT OF THERAPEUTIC STRATEGY
- Principal Investigator
  
  IKEDA Hitoshi
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  THE UNIVERSITY OF TOKYO

All 2007 2006 2005 2004 2003

All Journal Article Presentation

[Journal Article] Both plasma lysophosphatidic acid and serum autotaxin levels are increased in chronic hepatitis C.2007
- Author(s)
  Watanabe N, Ikeda H, Nakamura K, Obkawa R, Kume Y, Aoki J, Hama K, Okudaira S, Tanaka M, Tonriya T, Yanase M, Tejima K, Nishikawa T, Arai M, Arai H, Omata M, Fujiwara K, Yatomi Y.
- Journal Title
  
  J Clin Gastroenterol 41
  
  Pages: 616-623
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590719
[Journal Article] Plasma lysophosphatidic acid level and serum autotaxin activity are increased in liver injury in rats in relation to its severity2007
- Author(s)
  Watanabe N, Ikeda H, Nakamura K, Ohkawa R, Kume Y, Tomiya T, Tejima K, Nishikawa T, Arai M, Yanase M, Aoki J, Arai H, Omata M, Fujiwara K, Yatomi Y.
- Journal Title
  
  Life Sci 81
  
  Pages: 1009-1015
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590719
[Journal Article] Induction of ischemic tolerance in rat liver via reduced nicotinamide adenine dinucleotide phosphate oxidase in Kupffer cells2007
- Author(s)
  Tejima K, Arai M, Ikeda H, Tomiya T, Yanase M, Inoue Y, Nishikawa T, Watanabe N, Ohtomo N, Omata M, Fujiwara K.
- Journal Title
  
  World J Gastroenterol 13
  
  Pages: 5071-5078
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590719
[Journal Article] Ischemic preconditioning in liver pathophysiology2007
- Author(s)
  Arai M, Tejima K, Ikeda H, Tomiya T, Yanase M, Inoue Y, Nagashima K, Nishikawa T, Watanabe N, Omata M, Fujiwara K.
- Journal Title
  
  J Gastroenterol Hepatol 22 : S1
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590719
[Journal Article] Effect of rapamycin on hepatocyte function and proliferation induced by growth factors.2007
- Author(s)
  Tomiya T, Yamaoka M, Inoue Y, Nishikawa T, Yanase M, Ikeda H, Tejima K, Nagashima K, Watanabe N, Omata M, Fujiwara K.
- Journal Title
  
  Chemotherapy 53
  
  Pages: 59-69
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590719
[Journal Article] Induction of ischemic tolerance in rat liver via reduced nicotinamide adenine dinucleotide phosphate oxidase in Kupffer cells.2007
- Author(s)
  Tejima K, Arai M, Ikeda H, Tomiya T, Yanase M, moue Y, Nishikawa T, Watanabe N, Ohtomo N, Omata M, fujiwara K.
- Journal Title
  
  World J Gastroenterol 13
  
  Pages: 5071-5078
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590719
[Journal Article] Plasma 1ysophosphatidic acid level and serum autotaxin activity are increased in in liver injury in rats in relation to its severity2007
- Author(s)
  Watanabe N, Ikeda H, Nakamura K, Ohkawa R, Kume Y, Tomiya T, Tejima K, Nishikawa T, Arai M, Yanase M, Aoki J, Arai H, Omata M Fujiwara K, Yatomi Y.
- Journal Title
  
  Life Sci 81
  
  Pages: 1009-1015
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590719
[Journal Article] Effect of rapamycin on hepatocyte function and proliferation induced by growth factors2007
- Author(s)
  Tomiya T, Yamaoka M, Inoue Y, Nishikawa T, Yanase M, Ikeda H, Tejima K, Nagashima K, Watanabe N, Omata M, Fujiwara K.
- Journal Title
  
  Chemotherapy 53
  
  Pages: 59-69
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590719
[Journal Article] Effect of rapamycin on hepatocyte function and proliferation induced by growth factors.2007
- Author(s)
  Tomiya T, Yamaoka M, Inoue Y, Nishikawa T, Yanase M, Ikeda H, Tejima K, et al.
- Journal Title
  
  Chemotherapy 53・1
  
  Pages: 59-69
- Data Source
  KAKENHI-PROJECT-18590719
[Journal Article] The herbal medicine inchin-ko-to (TJ-135) induces apoptosis in cultured rat hepatic stellate cells.2006
- Author(s)
  Ikeda H, Nagashima K, Yanase M, Tomiya T, Arai M, Inoue Y, Tejima K, et al.
- Journal Title
  
  Life Sciences 78・19
  
  Pages: 2226-2233
- Data Source
  KAKENHI-PROJECT-18590719
[Journal Article] Hepatocyte preconditioning via activation of NADPH oxidase in Kupffer cells against warm ischemia/reperfusion injury.2005
- Author(s)
  Tejima K, Arai M, Ikeda H, Tomiya T, Yanase M, et al.
- Journal Title
  
  Hepatology 42(4)
- Data Source
  KAKENHI-PROJECT-17590615
[Journal Article] Hepatocyte preconditioning via activation of NADPH oxidase in Kupffer cells against warm ischemia/reperfusion injury.2005
- Author(s)
  Tejima K, Arai M, Ikeda H, Tomiya T, Yanase M et al.
- Journal Title
  
  Hepatology 42(4)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590615
[Journal Article] Sphingosine 1-phosphate enhances portal pressure in isolated perfused liver via S1P2 with Rho activation.2004
- Author(s)
  Ikeda H, Nagashima K, Yanase M, Tomiya T, Arai M, et al.
- Journal Title
  
  Biochem Biophys Res Commun. 320
  
  Pages: 754-759
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590625
[Journal Article] Ischemic preconditioning protects hepatocytes via reactive oxygen species derived from Kupffer cells in rats.2004
- Author(s)
  Tejima K, Arai M, Ikeda H, Tomiya T, Yanase M, et al.
- Journal Title
  
  Gastroenterology 127
  
  Pages: 1488-1496
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590625
[Journal Article] Sphingosine 1-phosphate enhances portal pressure in isolated perfused liver via S1P2 with Rho activation.2004
- Author(s)
  Ikeda H, Nagashima K, Yanase M, Tomiya T, Arai M, et al.
- Journal Title
  
  Biochem Biophys Res Commun 320
  
  Pages: 754-759
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590625
[Journal Article] HMG-COA reductase inhibitor modulates collagen GEL-contraction by hepatic myofibroblast-like stellate cell line : involvement of geranylgeranylated proteins.2004
- Author(s)
  Yanase M, Ikeda H, Matsui A, Noiri E, Tomiya T, et al.
- Journal Title
  
  Comp Hepatol 3
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590625
[Journal Article] Treatment with leucine stimulates the production of hepatocyte growth factor in vivo.2004
- Author(s)
  Tomiya T, Inoue Y, Yanase M, Arai M, Ikeda H et al.
- Journal Title
  
  Biochem Biophys Res Commun. 322
  
  Pages: 772-777
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590625
[Journal Article] HMG-COA reductase inhibitor modulates collagen GEL-contraction by hepatic myofibroblast-like stellate cell line : involvement of geranylgeranylated proteins.2004
- Author(s)
  Yanase M, Ikeda H, Matsui A, Noiri E, Tomiya T, et al.
- Journal Title
  
  Comp Hepatol. 3
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590625
[Journal Article] Ischemic preconditioning protects hepatocytes via reactive oxygen species derived from Kupffer cells in rats.2004
- Author(s)
  Tajima K, Arai M, Ikeda H, Tomiya T, Yanase M, et al.
- Journal Title
  
  Gastroenterology 127
  
  Pages: 1488-1496
- Data Source
  KAKENHI-PROJECT-15590625
[Journal Article] Antiproliferative Property of Sphingosine 1-Phosphate in Rat Hepatocytes Involves Activation of Rho Via Edg-5.2003
- Author(s)
  Ikeda H, Satoh H, Yanase M, Inoue Y, Tomiya T, et al.
- Journal Title
  
  Gastroenterology 124
  
  Pages: 459-469
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590625
[Journal Article] Functional Diversity between Rho-Kinase and MLCK-Mediated Cytoskeletal Actions in a Myofibroblast-Like Hepatic Stellate Cell Line.2003
- Author(s)
  Yanase M, Ikeda H, Ogata I, Matsui A, Noiri E, Tomiya T, et al.
- Journal Title
  
  Biochem Biophys Res Commun. 305
  
  Pages: 223-228
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590625
[Journal Article] Involvement of Rho/Rho kinase pathway in regulation of apoptosis in rat hepatic stellate cells.2003
- Author(s)
  Skeda H, Nagashima K, Yanase M, Tomiya T, et al.
- Journal Title
  
  Am J Physiol Gastrointest Liver Physiol 285
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590625
[Journal Article] Functional Diversity between Rho-Kinase-and MLCK-Mediated Cytoskeletal Actions in a Myofibroblast-Like Hepatic Stellate Cell Line.2003
- Author(s)
  Yanase M, Ikeda H, Ogata I, Matsui A, Noiri E, Tomiya T, et al.
- Journal Title
  
  Biochem Biophys Res Commun 305
  
  Pages: 223-228
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590625
[Journal Article] Involvement of Rho/Rho kinase pathway in regulation of apoptosis in rat hepatic stellate cells.2003
- Author(s)
  Ikeda H, Nagashima K, Yanase M, Tomiya T, et al.
- Journal Title
  
  Am J Physiol Gastrointest Liver Physiol 285
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590625
[Presentation] Induction of P53-related effector genes may regulate hepatocyte proliferation stimulated by hepatocyte growth factor2006
- Author(s)
  Tomiya T, Inoue Y, Nishikawa T, Ohtomo N, Yanase M, Ikeda H, Tejima K, Omata M, Fujiwara K.
- Organizer
  FASEB Summer Research Conference
- Place of Presentation
  Colorado, USA
- Year and Date
  2006-07-24
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590719
[Presentation] Induction of P53-related effector genes may regulate hepatocyte proliferation stimulated by hepatocyte growth factor2006
- Author(s)
  Tomiya T, Inoue Y, Nishikawa T, Ohtomo N, Yanase M, Ikeda H, Tejima K, Omata M, Fujiwara K.
- Organizer
  FASEB Summer Research Conference
- Place of Presentation
  Snowmass, Colorado, USA
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590719

1. TOMITA Tomoaki (90227637)

# of Collaborated Projects: 9 results

# of Collaborated Products: 25 results
2. IKEDA Hitoshi (80202422)

# of Collaborated Projects: 9 results

# of Collaborated Products: 25 results
3. ARAI Masahiro (60271566)

# of Collaborated Projects: 6 results

# of Collaborated Products: 5 results
4. TEJIMA Kazuaki (30396733)

# of Collaborated Projects: 3 results

# of Collaborated Products: 14 results
5. YATOMI Yutaka (60200523)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Yanase Mikio 柳瀬 幹雄

YANASE Mikio 柳瀬 幹雄

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Functional Analysis of The Biological Activities of a Lipid Mediator, Lysophoshatidie Acid, on The Pathogenesis of Liver FibrosisPrincipal Investigator

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[Journal Article] Both plasma lysophosphatidic acid and serum autotaxin levels are increased in chronic hepatitis C.2007

Author(s)

Journal Title

Description

Data Source

[Journal Article] Plasma lysophosphatidic acid level and serum autotaxin activity are increased in liver injury in rats in relation to its severity2007

Author(s)

Journal Title

Description

Data Source

[Journal Article] Induction of ischemic tolerance in rat liver via reduced nicotinamide adenine dinucleotide phosphate oxidase in Kupffer cells2007

Author(s)

Journal Title

Description

Data Source

[Journal Article] Ischemic preconditioning in liver pathophysiology2007

Author(s)

Journal Title

Description

Data Source

[Journal Article] Effect of rapamycin on hepatocyte function and proliferation induced by growth factors.2007

Author(s)

Journal Title

Data Source

[Journal Article] Induction of ischemic tolerance in rat liver via reduced nicotinamide adenine dinucleotide phosphate oxidase in Kupffer cells.2007

Author(s)

Journal Title

Description

Data Source

Yanase Mikio 柳瀬幹雄

YANASE Mikio 柳瀬幹雄