YAMAGUCHI Tomohiro 山口智広

Researcher Number	50347530
Other IDs
Affiliation (Current)	2022: 金城学院大学, 薬学部, 教授 2022: 昭和大学, 薬学部, 准教授
Affiliation (based on the past Project Information) *help	2009 – 2017: Showa University, 薬学部, 准教授 2016: 金城学院大学, 薬学部, 教授 2007 – 2008: 兵庫県立大学, 大学院・生命理学研究科, 助教 2004 – 2006: 兵庫県立大学, 大学院・生命理学研究科, 助手 2005: University of Hyogo, Graduate School of Life Science, Assistant Professor, 大学院生命理学研究科, 助手 2003: 姫路工業大学, 大学院・理学研究科, 助手
Review Section/Research Field	Principal Investigator Cell biology / Biological pharmacy Except Principal Investigator Functional biochemistry / Biological pharmacy
Keywords	Principal Investigator 脂肪滴 / 脂質代謝 / CGI-58 / ペリリピン / 3T3-L1細胞 / 細胞構造・機能 / 脂質 / 中性脂肪 / 細胞・組織 / 蛋白質 … More Except Principal Investigator 脂肪滴 / 脂肪細胞 / ペリリピン / PPARγ / PPARα / 心臓 / ノックアウトマウス / 中性脂肪 / 脂肪酸 / 心筋症 / 脂肪滴結合タンパク質 / MLDP / 脂質代謝 / 糖尿病 / PATタンパク質 / 脂肪分解 / トリグリセリド / 分化 / 核内レセプター / ヒト間葉系幹細胞 / ペルオキシソーム / ノックダウン / PEX遺伝子 / 3T3-L1 / PPAR / C / EBPα / EBPβ / 間葉系幹細胞 / Adipocytes / Differentiation / Perilipin / Lipid droplet / Nuclear receptor / Human mesenchymal stem cells / 酸化LDL / 動脈硬化 / 質量分析 / 安定同位体標識 / リピドミクス / リポタンパク質 / LC-MS/MS / 酸化リン脂質 / LCAT / リゾPC / Lp-PLA2 / リゾホスファチジルコリン Less

Studies on process of generation and metabolism of oxidized LDL in vivo.
- Principal Investigator
  
  ITABE Hiroyuki
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Showa University
Mechanisms of remodeling of white adipocytes to brown-like adipocytes (browning) in human mesenchymal stem cells.Principal Investigator
- Principal Investigator
  
  YAMAGUCHI Tomohiro
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Kinjo Gakuin University
  Showa University
The role of lipid droplets in the steroid hormone synthesis in MLTC-1 mouse Leydig tumor cells.Principal Investigator
- Principal Investigator
  
  YAMAGUCHI Tomohiro
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Showa University
The role of MLDP in lipid metabolism on lipid droplets.Principal Investigator
- Principal Investigator
  
  YAMAGUCHI Tomohiro
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Cell biology
- Research Institution
  University of Hyogo
Studies of Lipid Droplets : Intracellular Dynamics and Regulatory Mechanisms of Functions
- Principal Investigator
  
  OSUMI Takashi
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  University of Hyogo
脂肪滴膜で機能するドーフマン-チャナリン症候群の原因因子CGI-58の解析Principal Investigator
- Principal Investigator
  
  山口智広
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Cell biology
- Research Institution
  University of Hyogo
Identification and functional analysis of intrinsic and extrinsic key regulators of adipocyte differentiation.
- Principal Investigator
  
  OSUMI Takashi
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  University of Hyogo
  Himeji Institute of Technology

All 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2004 Other

All Journal Article Presentation Book

[Book] 分子糖尿病学の進歩-基礎から応用まで-20082008
- Author(s)
  山口智広、大隅隆, 他
- Publisher
  金原出版
- Data Source
  KAKENHI-PROJECT-20770160
[Journal Article] Perilipins: A diversity of intracellular lipid droplet proteins.2017
- Author(s)
  Hiroyuki Itabe, Tomohiro Yamaguchi, Satomi Nimura, Naoko Sasabe
- Journal Title
  
  Lipids in Health and Diseases
  
  Volume: 16 Pages: 83-83
- DOI
  10.1186/s12944-017-0473-y
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07944
[Journal Article] Characterization of lipid droplets in steroidogenic MLTC-1 Leydig cells: Protein profiles and the morphological change induced by hormone stimulation.2015
- Author(s)
  Yamaguchi T, Fujikawa N, Nimura S, Tokuoka Y, Tsuda S, Aiuchi T, Kato R, Obama T, Itabe H.
- Journal Title
  
  Biochim. Biophys. Acta.
  
  Volume: 1851 Pages: 1285-1295
- DOI
  10.1016/j.bbalip.2015.06.007
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K07944, KAKENHI-PROJECT-26460077
[Journal Article] Olanzapine promotes the accumulation of lipid droplets and the expression of multiple perilipins in human adipocytes.2015
- Author(s)
  Nimura S, Yamaguchi T, Ueda K, Kadokura K, Aiuchi T, Kato R, Obama T, Itabe H.
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 467 Pages: 906-912
- DOI
  10.1016/j.bbrc.2015.10.045
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K07944, KAKENHI-PROJECT-26460077
[Journal Article] Crucial Role of Perilipin-3 (TIP47) in Formation of Lipid Droplets and PGE_2 Production in HL-60-Derived Neutrophils2013
- Author(s)
  Nose F, Yamaguchi T, Kato R, Aiuchi T, Obama T, Hara S, Yamamoto M, Itabe H.
- Journal Title
  
  PLoS One
  
  Volume: 8 Pages: 71542-71542
- DOI
  10.1371/journal.pone.0071542
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790098, KAKENHI-PROJECT-24590094, KAKENHI-PROJECT-24790087, KAKENHI-PUBLICLY-25116720
[Journal Article] (*Equal Contribution) Perilipin 5, a Lipid Droplet-binding Protein, Protects Heart from Oxidative Burden by Sequestering Fatty Acid from Excessive Oxidation2012
- Author(s)
  Kuramoto K, Okamura T, Yamaguchi T, Nakamura TY, Wakabayashi S, Morinaga H, Nomura M, Yanase T, Otsu K, Usuda N, Matsumura S, Inoue K, Fushiki T, Kojima Y, Hashimoto T, Sakai F, Hirose F, Osumi T
- Journal Title
  
  J Biol Chem
  
  Volume: 287 Pages: 23852-23863
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790098
[Journal Article] Active involvement of micro-lipid droplets and lipid droplet-associated proteins in hormone-stimulated lipolysis in adipocytes2012
- Author(s)
  Hashimoto T, Segawa H, Okuno M, Kano H, Hamaguchi HO, Haraguchi T, Hiraoka Y, Hasui S, Yamaguchi T, Hirose F, Osumi T
- Journal Title
  
  J Cell Sci
  
  Volume: 125 Pages: 6127-6136
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790098
[Journal Article] Unique regulation of adipose triglyceride lipase (ATGL) by perilipin 5, a lipid droplet-associated protein2011
- Author(s)
  Wang H, Bell M, Sreenevasan U, Hu H, Liu J, Dalen K, Londos C, Yamaguchi T, Rizzo MA, Coleman R, Gong D, Brasaemle D, Sztalryd C
- Journal Title
  
  J Biol Chem
  
  Volume: 286 Pages: 15707-15715
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790098
[Journal Article] Oxidized low-density lipoprotein-induced periodontal inflammation is associated with the up-regulation of cyclooxygenase -2 and microsomal prostaglandin synthase 1 in human gingival epithelial cells2011
- Author(s)
  Nagahama Y, Obama T, Usui M, Kanazawa Y, Iwamoto S, Suzuki K, Miyazaki A, Yamaguchi T, Yamamoto M, Itabe H
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 413 Pages: 566-571
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790098
[Journal Article] Dietary cholesterol reduces plasma triacylglycerol in apolipoprotein E-null mice : suppression of lipin-1 and -2 in the glycerol-3-phosphate2011
- Author(s)
  Takashi Obama, et al
- Journal Title
  
  PLoS One
  
  Volume: 6 Pages: 22917-22917
- DOI
  10.1371/journal.pone.0022917
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590073, KAKENHI-PROJECT-22500390, KAKENHI-PROJECT-23790098
[Journal Article] Crucial role of CGI-58/α/β hydrolase domain-containing protein 5 in lipid metabolism.2010
- Author(s)
  Yamaguchi T.
- Journal Title
  
  Biol.Pharm.Bull. 33
  
  Pages: 342-325
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20770160
[Journal Article] Crucial role of CGI-58/alpha/beta hydrolase domain-containing protein 5 in lipid metabolism2010
- Author(s)
  Yamaguchi T
- Journal Title
  
  Biol Pharm Bull. 33
  
  Pages: 342-345
- NAID
  130000248078
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20770160
[Journal Article] Glucagon regulates intracellular distribution of adipose differentiation-related protein during triacylglycerol accumulation in the liver.2010
- Author(s)
  Takahashi K., Sasabe N., Ohshima K., Kitazato K., Kato R., Masuda Y., Tsurumaki M., Obama T., Okudaira S., Aoki J., Arai H., Yamaguchi T., Itabe H.
- Journal Title
  
  J.Lipid Res. 51
  
  Pages: 2571-2580
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20770160
[Journal Article] Chanarin-Dorfman syndrome : Deficiency in CGI-58, a lipid droplet-bound coactivator of lipase2009
- Author(s)
  Yamaguchi, Tomohiro
- Journal Title
  
  Biochimica et Biophysica Acta 1791
  
  Pages: 519-523
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19370056
[Journal Article] Activation of hormone-sensitive lipase requires two steps, protein phosphorylation and binding to the PAT-1 domain of lipid droplet coat proteins.2009
- Author(s)
  Wang H., Hu L., Dalen K., Dorward H., Marcinkiewicz A., Russell D., Gong D., Londos C., Yamaguchi T., Holm C., Rizzo MA., Brasaemle D., Sztalryd C.
- Journal Title
  
  J.Biol.Chem. 284
  
  Pages: 32116-32125
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20770160
[Journal Article] Chanarin-Dorfman syndrome : Deficiency in CGI-58, a lipid droplet-bound coactivator of lipase2009
- Author(s)
  Yamaguchi, Tomohiro
- Journal Title
  
  Biochim. Biophys. Acta (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19370056
[Journal Article] Chanarin-Dorfman syndrome : deficiency in CGI-58, a lipid droplet-bound coactivator of lipase.2009
- Author(s)
  Yamaguchi T., Osumi T.
- Journal Title
  
  Biochim Biophys Acta. 1791
  
  Pages: 519-523
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20770160
[Journal Article] Chanarin-Dorfman syndrome: Deficiency in CGI-58, a lipid droplet-bound coactivator of lipase.2009
- Author(s)
  Yamaguchi, T., Osumi, T.
- Journal Title
  
  Biochim. Biophys. Acta 1791
  
  Pages: 519-523
- Data Source
  KAKENHI-PROJECT-19370056
[Journal Article] Perilipin, a critical regulator of fat storage and breakdown, is a target gene of estrogen receptor-related receptorα.2008
- Author(s)
  Akter MH., Yamaguchi T., Hirose F., Osumi T.
- Journal Title
  
  Biochem.Biophys.Res.Commun. 368
  
  Pages: 563-568
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20770160
[Journal Article] Perilipin, a critical regulator of fat storage and breakdown, is a target gene of estrogen receptor-related receptor α.2008
- Author(s)
  Akter, Mst. H., Yamaguchi, T., Hirose, F., Osumi, T.
- Journal Title
  
  Biochem. Biophys. Res. Commun. 368
  
  Pages: 563-568
- Data Source
  KAKENHI-PROJECT-19370056
[Journal Article] FSP27 contributes to efficient energy storage in murine white adipocytes by promoting the formation of unilocular lipid droplets.2008
- Author(s)
  Nishino N., Tamori Y., Tateya S., Kawaguchi T., Shibakusa T., Mizunoya W., Inoue K., Kitazawa R., Kitazawa S., Matsuki Y., Hiramatsu R., Masubuchi S., Omachi A., Kimura K, Saito M., Amo T., Ohta S., Yamaguchi T., Osumi T., Cheng J., Fujimoto T., Nakao H., Nakao K., Aiba A., Okamura H., Fushiki T, Kasuga M.
- Journal Title
  
  J.Clin.Invest. 118
  
  Pages: 2808-2821
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20770160
[Journal Article] Target specificities of estrogen receptor-related receptors: Analysis of binding sequences and identification of Rb1-inducible coiled-coil 1 (Rb1cc1) as a target gene.2008
- Author(s)
  Akter, Mst. H., Chano, T., Okabe, H., Yamaguchi, T., Hirose, F., Osumi, T.
- Journal Title
  
  J. Biochem. 143
  
  Pages: 395-406
- NAID
  10024908925
- Data Source
  KAKENHI-PROJECT-19370056
[Journal Article] CGI-58 facilitates lipolysis on lipid droplets but is not involved in the vesiculation of lipid droplets caused by hormonal stimulation2007
- Author(s)
  Yamaguchi, Tomohiro
- Journal Title
  
  Journal of Lipid Research 48
  
  Pages: 1078-1089
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19370056
[Journal Article] Analysis of interaction partners for perilipin and ADRP on lipid droplets2006
- Author(s)
  YAMAGUCHI, Tomohiro
- Journal Title
  
  Molecular and Cellular Biochemistry (In press)
- Data Source
  KAKENHI-PROJECT-15370061
[Journal Article] MLDP, a novel PAT family protein localized to lipid droplets and enriched in the heart, is regulated by peroxisome proliferator-activated receptor-α.2006
- Author(s)
  山口智広
- Journal Title
  
  J. Biol. Chem. 281
  
  Pages: 14232-14240
- Data Source
  KAKENHI-PROJECT-16770155
[Journal Article] Analysis of interaction partners for perilipin and ADRP on lipid droplets2006
- Author(s)
  Yamaguchi, Tomohiro
- Journal Title
  
  Molecular and Cellular Biochemistry 286(in press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15370061
[Journal Article] Analysis of interaction partners for perilipin and ADRP on lipid droplets2006
- Author(s)
  山口智広
- Journal Title
  
  Mol.Cell Biochem. (印刷中)
- Data Source
  KAKENHI-PROJECT-16770155
[Journal Article] MLDP, a novel PAT family protein localized to lipid droplets and enriched in the heart, is regulated by peroxisome proliferator-activated receptor α2006
- Author(s)
  YAMAGUCHI, Tomohiro
- Journal Title
  
  The Journal of Biological Chemistry (In press)
- Data Source
  KAKENHI-PROJECT-15370061
[Journal Article] MLDP, a novel PAT family protein localized to lipid droplets and enriched in the heart, is regulated by peroxisome proliferator-activated receptor α2006
- Author(s)
  Yamaguchi, Tomohiro
- Journal Title
  
  The Journal of Biological Chemistry 281(in press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15370061
[Journal Article] CGI-58 interacts with perilipin and is localized to lipid droplets : Possible involvement of CGI-58 mislocalization in chanarin-Dorfman syndrome2004
- Author(s)
  Yamaguchi, Tomohiro
- Journal Title
  
  The Journal of Biological Chemistry 279
  
  Pages: 30490-30497
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15370061
[Journal Article] CGI-58 interacts with perilipin and is localized to lipid droplets : Possible involvement of CGI-58 mislocalization in Chanarin-Dorfman syndrome.2004
- Author(s)
  YAMAGUCHI, Tomohiro
- Journal Title
  
  The Journal of Biological Chemistry 279
  
  Pages: 30490-30497
- Data Source
  KAKENHI-PROJECT-15370061
[Journal Article] CGI-58 interacts with perilipin and is localized to lipid droplets: Possible involvement of CGI-58 mislocalization in chanarin-Dorfman syndrome2004
- Author(s)
  Yamaguchi, Tomohiro
- Journal Title
  
  The Journal of Biological Chemistry 279
  
  Pages: 30490-30497
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15370061
[Journal Article] CGI-58 interacts with perilipin and is localized to lipid droplets : Possible involvement of CGI-58 mislocalization in Chanarin-Dorfman syndrome2004
- Author(s)
  山口智広, 大松尚登, 松下周平, 大隅隆
- Journal Title
  
  Journal of Biological Chemistry 279
  
  Pages: 30490-30497
- Data Source
  KAKENHI-PROJECT-16770155
[Journal Article] Analysis of interaction partners for perilipin and ADRP on lipid droplets
- Author(s)
  Yamaguchi, Tomohiro
- Journal Title
  
  Molecular and Cellular Biochemistry 286(in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15370061
[Journal Article] MLDP, a novel PAT family protein localized to lipid droplets and enriched in the heart, is regulated by peroxisome proliferator-activated receptor α
- Author(s)
  Yamaguchi, Tomohiro
- Journal Title
  
  The Journal of Biological Chemistry 281(in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15370061
[Presentation] 安定同位体リピドミクスによる酸化LDL-HDL間の脂質利モデリングの解析2016
- Author(s)
  増田しおり、高田夏鈴、小浜孝士、相内敏弘、加藤里奈、山口智広、板部洋之
- Organizer
  日本薬学会第136年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-15K07944
[Presentation] Reduced expression of peroxiredoxin 2 in smooth muscle cells at the onset of atherogenesis in apoE-knockout mice.2015
- Author(s)
  Itabe H, Kato R, Hayashi M, Obama T, Aiuchi T, Yamaguchi T.
- Organizer
  11th International Congress on Coronary Artery Disease
- Place of Presentation
  フローレンス
- Year and Date
  2015-11-29
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07944
[Presentation] ヒト間葉系幹細胞(hMSC)由来の脂肪細胞の分化に関する研究2014
- Author(s)
  二村哲未,山口智広,上原弥未,菅井瞳,猪砂絵美,橘洋介,渕上圭子,中西里奈,笹部直子,加藤里奈,板部洋之
- Organizer
  日本薬学会第133年会
- Place of Presentation
  熊本
- Year and Date
  2014-03-28
- Data Source
  KAKENHI-PROJECT-23790098
[Presentation] ヒト脂肪由来幹細胞（ADSC）および間葉系幹細胞（hMSC）由来の脂肪細胞における脂肪滴の解析2014
- Author(s)
  山口智広
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  国立京都国際会館
- Year and Date
  2014-10-17
- Data Source
  KAKENHI-PROJECT-26460077
[Presentation] Perilipin-3/TIP47はHL-60由来好中球における脂肪滴の形成とプロスタグランジンE_2の産生に関与する2013
- Author(s)
  野瀬冬樹、山口智広、相内敏弘、小浜孝士、加藤里奈、山本松男、板部洋之
- Organizer
  第86回日本生化学会
- Place of Presentation
  横浜
- Year and Date
  2013-09-12
- Data Source
  KAKENHI-PROJECT-23790098
[Presentation] Perilipin-3/TIP47はHL-60由来好中球における脂肪滴の形成とプロスタグランジンE2の産生に関与する2013
- Author(s)
  野瀬冬樹、○山口智広、相内敏弘、小浜孝士、加藤里奈、山本松男、板部洋之
- Organizer
  日本生化学会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Data Source
  KAKENHI-PROJECT-23790098
[Presentation] HL-60好中球においてPerilipin-3/TIP47は脂肪滴形成とプロスタグランジンE2産生に関与する2013
- Author(s)
  野瀬冬樹、○山口智広、相内敏弘、小浜孝士、加藤里奈、山本松男、板部洋之
- Organizer
  脂質生化学会
- Place of Presentation
  ホテル松島大観荘（宮城県宮城郡）
- Data Source
  KAKENHI-PROJECT-23790098
[Presentation] HL-60好中球においてPerilipin-3/TIP47は脂肪滴形成とプロスタグランジンE_2産生に関与する2013
- Author(s)
  野瀬冬樹、山口智広、相内敏弘、小浜孝士、加藤里奈、山本松男、板部洋之
- Organizer
  第55回脂質生化学会
- Place of Presentation
  松島
- Year and Date
  2013-06-07
- Data Source
  KAKENHI-PROJECT-23790098
[Presentation] 細胞内脂肪滴における中性脂肪の蓄積と分解の制御機構2012
- Author(s)
  山口智広
- Organizer
  第56回日本薬学会関東支部大会
- Place of Presentation
  品川
- Year and Date
  2012-10-13
- Data Source
  KAKENHI-PROJECT-23790098
[Presentation] 細胞内脂肪滴における中性脂肪の蓄積と分解の制御機構2012
- Author(s)
  山口智広
- Organizer
  第56回　日本薬学会関東支部大会
- Place of Presentation
  昭和大学
- Invited
- Data Source
  KAKENHI-PROJECT-23790098
[Presentation] マウスライディッヒ細胞株(MLTC-1)における脂肪滴タンパク質の機能解析2012
- Author(s)
  山口智広、藤川典之、長澤充、櫻井敦史、小浜孝士、加藤里奈、板部洋之
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Year and Date
  2012-03-29
- Data Source
  KAKENHI-PROJECT-23790098
[Presentation] MLTC-1細胞のステロイドホルモン産生に伴う脂肪滴の形態変化2012
- Author(s)
  山口智広
- Organizer
  日本薬学会第132年会
- Place of Presentation
  北海道大学（札幌）
- Data Source
  KAKENHI-PROJECT-23790098
[Presentation] The role of lipid droplets in the steroid hormone synthesis in Leydig cells2011
- Author(s)
  Tomohiro Yamaguchi
- Organizer
  The 30th Naito Conference on Membrane Dynamics and Lipid Biology[II]
- Place of Presentation
  札幌
- Year and Date
  2011-06-29
- Data Source
  KAKENHI-PROJECT-23790098
[Presentation] ステロイド産生細胞(MLTC-1)における脂肪滴局在タンパク質の解析2011
- Author(s)
  山口智広、藤川典之、相内敏弘、津田園佳、徳岡雄太郎、二村哲未、小浜孝士、加藤里奈、板部洋之
- Organizer
  第53回脂質生化学会
- Place of Presentation
  東京
- Year and Date
  2011-05-12
- Data Source
  KAKENHI-PROJECT-23790098
[Presentation] The role of lipid droplets in the steroid hormone synthesis in Leydig cells2011
- Author(s)
  山口智広
- Organizer
  The 30th Naito Conference on Membrane Dynamics and Lipid Biology[II]
- Place of Presentation
  シャトレーゼガトーキングダム（札幌）
- Data Source
  KAKENHI-PROJECT-23790098
[Presentation] 脂肪滴局在タンパク質PERILIPINファミリーによる脂質代謝制御2011
- Author(s)
  山口智広
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡
- Year and Date
  2011-03-30
- Data Source
  KAKENHI-PROJECT-20770160
[Presentation] 脂肪分解刺激に応答した脂肪滴局在タンパク質の細胞内動態の解析2009
- Author(s)
  山口智広
- Organizer
  日本脂質生化学会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-20770160
[Presentation] 脂肪滴局在タンパク質PATファミリーの機能特異性の解析2008
- Author(s)
  南部千恵、橋本健志、山口智広、廣瀬富美子、大隅隆
- Organizer
  第31回日本分子生物学会、第81回日本生化学会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-19370056
[Presentation] 転写因子hDREFによるクロマチンリモデリング因子Mi-2aのSUMO化とその意味2008
- Author(s)
  廣瀬富美子、大和茜、山口智広、大隅隆
- Organizer
  第31回日本分子生物学会、第81回日本生化学会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-19370056
[Presentation] 脂肪分解刺激に対する脂肪滴表面タンパク質の応答の解析2008
- Author(s)
  橋本健志、森本絵美、原口徳子、平岡泰、加納英明、濱口宏夫、山口智広、廣瀬富美子、大隅隆
- Organizer
  第31回日本分子生物学会、第81回日本生化学会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-19370056
[Presentation] 脂肪滴での脂肪の分解と蓄積におけるPATファミリータンパク質の役割2007
- Author(s)
  山口智広
- Organizer
  第30回日本分子生物学会、第80回日本生化学会合同大会
- Place of Presentation
  横浜
- Year and Date
  2007-12-11
- Data Source
  KAKENHI-PROJECT-19370056
[Presentation] 脂肪滴での脂肪の分解と蓄積におけるPATファミリータンパク質の役割.2007
- Author(s)
  山口智広、大隅隆
- Organizer
  第30回日本分子生物学会、第80回日本生化学会合同大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19370056

1. OSUMI Takashi (50111787)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
2. OKAMURA Tomoo (90553991)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. HIROSE Fumiko (60208882)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. ITABE Hiroyuki (30203079)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
5. 小濱孝士 (60395647)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 加藤里奈 (30392400)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
7. 笹部直子 (50643566)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. OBAMA Takashi

# of Collaborated Projects: 0 results

# of Collaborated Products: 6 results
9. 原俊太郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

YAMAGUCHI Tomohiro 山口 智広

Research Projects

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Studies on process of generation and metabolism of oxidized LDL in vivo.

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Mechanisms of remodeling of white adipocytes to brown-like adipocytes (browning) in human mesenchymal stem cells.Principal Investigator

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The role of lipid droplets in the steroid hormone synthesis in MLTC-1 mouse Leydig tumor cells.Principal Investigator

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The role of MLDP in lipid metabolism on lipid droplets.Principal Investigator

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Studies of Lipid Droplets : Intracellular Dynamics and Regulatory Mechanisms of Functions

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脂肪滴膜で機能するドーフマン-チャナリン症候群の原因因子CGI-58の解析Principal Investigator

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Identification and functional analysis of intrinsic and extrinsic key regulators of adipocyte differentiation.

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[Book] 分子糖尿病学の進歩-基礎から応用まで-20082008

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[Journal Article] Perilipins: A diversity of intracellular lipid droplet proteins.2017

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[Journal Article] Characterization of lipid droplets in steroidogenic MLTC-1 Leydig cells: Protein profiles and the morphological change induced by hormone stimulation.2015

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[Journal Article] Olanzapine promotes the accumulation of lipid droplets and the expression of multiple perilipins in human adipocytes.2015

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[Journal Article] Crucial Role of Perilipin-3 (TIP47) in Formation of Lipid Droplets and PGE_2 Production in HL-60-Derived Neutrophils2013

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[Journal Article] (*Equal Contribution) Perilipin 5, a Lipid Droplet-binding Protein, Protects Heart from Oxidative Burden by Sequestering Fatty Acid from Excessive Oxidation2012

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[Journal Article] Active involvement of micro-lipid droplets and lipid droplet-associated proteins in hormone-stimulated lipolysis in adipocytes2012

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[Journal Article] Unique regulation of adipose triglyceride lipase (ATGL) by perilipin 5, a lipid droplet-associated protein2011

Author(s)

YAMAGUCHI Tomohiro 山口智広