sawada naoko 澤田直子 (笹部直子)

… Alternative Names

澤田直子サワダナオコ

笹部直子

笹部直子ササベナオコ

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Researcher Number	50643566
Other IDs
Affiliation (Current)	2026: 桜美林大学, リベラルアーツ学群, 特任准教授
Affiliation (based on the past Project Information) *help	2019 – 2021: 昭和大学, 薬学部, 助教 2016 – 2017: 昭和大学, 薬学部, 助教
Review Section/Research Field	Except Principal Investigator Basic Section 47030:Pharmaceutical hygiene and biochemistry-related / Biological pharmacy
Keywords	Except Principal Investigator LC-MS/MS / 酸化LDL / NETs / 急性心筋梗塞 / HDL / 好中球細胞外トラップ / 急性心筋後続 / 動脈硬化症 / 酸化HDL / リゾホスファチジルコリン … More / Lp-PLA2 / リゾPC / LCAT / 酸化リン脂質 / リポタンパク質 / リピドミクス / 安定同位体標識 / 質量分析 / 動脈硬化 Less

Oxidatively modified high-density lipoprotein: its roles in vessel wall tissues and mechanism of its generation.
- Principal Investigator
  
  ITABE Hiroyuki
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Showa University
Studies on process of generation and metabolism of oxidized LDL in vivo.
- Principal Investigator
  
  ITABE Hiroyuki
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Showa University

All 2021 2020 2019 2018 2017 2016

All Journal Article Presentation

[Journal Article] Structure and Dynamics of Oxidized Lipoproteins In Vivo: Roles of High-Density Lipoprotein2021
- Author(s)
  Itabe Hiroyuki、Sawada Naoko、Makiyama Tomohiko、Obama Takashi
- Journal Title
  
  Biomedicines
  
  Volume: 9 Issue: 6 Pages: 655-655
- DOI
  10.3390/biomedicines9060655
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07051, KAKENHI-PROJECT-19K07069
[Journal Article] Comparison of protein profiles of the pellicle, gingival crevicular fluid, and saliva: possible origin of pellicle proteins2020
- Author(s)
  Odanaka Hibiki、Obama Takashi、Sawada Naoko、Sugano Marika、Itabe Hiroyuki、Yamamoto Matsuo
- Journal Title
  
  Biological Research
  
  Volume: 53 Issue: 1 Pages: 3-3
- DOI
  10.1186/s40659-020-0271-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07051, KAKENHI-PROJECT-19K07069, KAKENHI-PROJECT-19K19034
[Journal Article] Transfer and enzyme-mediated metabolism of oxidized phosphatidylcholine and lysophosphatidylcholine between low- and high-density lipoproteins.2020
- Author(s)
  Naoko Sawada, Takashi Obama, Mirei Mizuno, Kiyoshi Fukuhara, Sanju Iwamoto, Toshihiro Aiuchi, Tomohiko Makiyama and Hiroyuki Itabe
- Journal Title
  
  Antioxidants
  
  Volume: 9 Issue: 11 Pages: 1045-1045
- DOI
  10.3390/antiox9111045
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07051, KAKENHI-PROJECT-20K15486, KAKENHI-PROJECT-18K06588
[Journal Article] Circulating oxidized LDL increased in patients with acute myocardial infarction is accompanied by heavily modified HDL.2020
- Author(s)
  Naoko Sawada, Takashi Obama, Shinji Koba, Takashi Takaki, Sanju Iwamoto, Toshihiro Aiuchi, Rina Kato, Masaki Kikuchi, Yuji Hamazaki, Hiroyuki Itabe.
- Journal Title
  
  Journal of Lipid Research
  
  Volume: 61
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07051
[Journal Article] Circulating oxidized LDL increased in patients with acute myocardial infarction is accompanied by heavily modified HDL.2020
- Author(s)
  Sawada Naoko、Obama Takashi、Koba Shinji、Takaki Takashi、Iwamoto Sanju、Aiuchi Toshihiro、Kato Rina、Kikuchi Masaki、Hamazaki Yuji、Itabe Hiroyuki
- Journal Title
  
  Journal of Lipid Research
  
  Volume: - Issue: 6 Pages: 816-829
- DOI
  10.1194/jlr.ra119000312
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K11426, KAKENHI-PROJECT-19K07051, KAKENHI-PROJECT-19K07069
[Journal Article] Cooperative action of oxidized low-density lipoproteins and neutrophils on endothelial inflammatory responses through neutrophil extracellular trap formation2019
- Author(s)
  Obama Takashi、Ohinata Hitomi、Takaki Takashi、Iwamoto Sanju、Sawada Naoko、Aiuchi Toshihiro、Kato Rina、Itabe Hiroyuki
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 10 Pages: 1899-1899
- DOI
  10.3389/fimmu.2019.01899
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07051, KAKENHI-PROJECT-19K07069, KAKENHI-PROJECT-19K07423
[Journal Article] Significance of oxidized low-density lipoprotein in body fluids as a marker related to diseased conditions.2018
- Author(s)
  Itabe Hiroyuki、Kato Rina、Sasabe Naoko、Obama Takashi、Yamamoto Matsuo
- Journal Title
  
  Curr Med Chem
  
  Volume: 25 Issue: 9 Pages: 1576-1593
- DOI
  10.2174/0929867325666180307114855
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08245, KAKENHI-PROJECT-15K07944, KAKENHI-PROJECT-19K07051
[Presentation] 血中酸化リポタンパク質生成におけるHDLの関わり2020
- Author(s)
  澤田直子、小濵孝士、巖本三壽、木庭新治、髙木孝士、相内敏弘、板部洋之
- Organizer
  第62回日本脂質生化学会
- Data Source
  KAKENHI-PROJECT-19K07051
[Presentation] Involvement of high-density lipoprotein in oxidatively modified forms of low-density lipoproteins in human circulation.2020
- Author(s)
  H. Itabe, N. Sawada T. Obama, S.
- Organizer
  SFRR-India 2020
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07051
[Presentation] 血中酸化リポタンパク質生成におけるHDLの関わり。2020
- Author(s)
  澤田直子、小濵孝士、巖本三壽、木庭新治、髙木孝士、相内敏弘、板部洋之
- Organizer
  第62回日本脂質生化学会
- Data Source
  KAKENHI-PROJECT-19K07051
[Presentation] HDLを伴った血中酸化リポタンパク質粒子の生成と動脈硬化症2020
- Author(s)
  澤田直子、板部洋之、小濵孝士、木庭新治、巖本三壽、髙木孝士、Wirapol Phimarn、牧山智彦、相内敏弘
- Organizer
  第93回日本生化学会
- Data Source
  KAKENHI-PROJECT-19K07051
[Presentation] 急性心筋梗塞患者血中に増加している酸化HDL-LDL複合体について2019
- Author(s)
  澤田直子、小濵孝士、巖本三壽、木庭新治、髙木孝士、相内敏弘、板部洋之
- Organizer
  第61回日本脂質生化学会
- Data Source
  KAKENHI-PROJECT-19K07051
[Presentation] Structure and compositional analysis of oxidized low-density lipoproteins present in plasma from healthy subjects and patients with atherosclerosis2019
- Author(s)
  Naoko Sawada, Takashi Obama, Sanju Iwamoto, Shinji Koba, Toshihiro Aiuchi, Rina Kato, Hiroyuki Itabe
- Organizer
  The 9th Biennial Meeting of Society for Free Radical Research-Asia
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07051
[Presentation] 安定同位体リピドミクスを利用したLDL-HDL間の酸化PC代謝解析2019
- Author(s)
  澤田直子、小濱孝士、福原潔、水野美麗、巖本三壽、相内敏弘、板部洋之
- Organizer
  第92回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19K07051
[Presentation] 血管内皮細胞の炎症誘導における好中球細胞外トラップと酸化LDLの関与」　日本薬学会第138年会2018
- Author(s)
  小浜孝士、池田葵、今井瑞菜、上田晃輝、門倉夏林、髙橋江里奈、澤田直子、相内敏弘、加藤里奈、板部洋之
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-15K07944
[Presentation] 動脈硬化症患者血漿中の酸化LDLの分離とその性状解析2018
- Author(s)
  澤田直子、小浜孝士、巖本三壽、木庭新治、相内敏弘、加藤里奈、板部洋之
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-15K07944
[Presentation] 動脈硬化初期病変進展過程における抗酸化タンパク質Peroxiredoxin 2及びThioredoxin低下による平滑筋細胞の酸化ストレス亢進2018
- Author(s)
  加藤里奈、嶋崎萌夏、小澤雪乃、知念良憲、渡辺窓香、上當明徳、高田紫苑、相内敏弘、澤田直子、小浜孝士、板部洋之
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-15K07944
[Presentation] 動脈硬化初期病変進展過程における平滑筋細胞の酸化ストレス上昇と形質変化の関係性2017
- Author(s)
  加藤里奈、嶋﨑萌夏、鈴木花菜、小澤雪乃、知念良憲、渡辺窓香、相内敏弘、笹部直子、小浜孝士、板部洋之
- Organizer
  第49回日本動脈硬化学会・学術集会
- Data Source
  KAKENHI-PROJECT-15K07944
[Presentation] 安定同位体リピドミクスを用いたHDLによるLDL酸化抑制機構の解析2017
- Author(s)
  笹部直子、小浜孝士、増田しおり、髙田夏鈴、相内敏弘、加藤里奈、板部洋之
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-15K07944
[Presentation] 歯肉溝滲出液中の酸化LDLと歯周病に伴う炎症について2017
- Author(s)
  石塚元規、板部洋之、加藤里奈、守屋佑美、山本松男、笹部直子、小浜孝士
- Organizer
  第59回日本脂質生化学会
- Data Source
  KAKENHI-PROJECT-15K07944
[Presentation] 動脈硬化進展初期過程における平滑筋細胞のPerxoiredoxin 2低下による酸化ストレス亢進と形質変化2017
- Author(s)
  加藤里奈、嶋﨑萌夏、鈴木花菜、小澤雪乃、知念良憲、渡辺窓香、相内敏弘、笹部直子、小浜孝士、板部洋之
- Organizer
  ConBio2017
- Data Source
  KAKENHI-PROJECT-15K07944
[Presentation] HDLによるLDL中の酸化PC代謝の安定同位体リピドミクスを用いた解析2017
- Author(s)
  笹部直子、小浜孝士、増田しおり、高田夏鈴、櫻井彩伽、長谷川拓也、福原潔、水野美麗、相内敏弘、加藤里奈、板部洋之
- Organizer
  ConBio2017
- Data Source
  KAKENHI-PROJECT-15K07944
[Presentation] ヒト血漿からの酸化LDL分離と脂質酸化による性状の変化2016
- Author(s)
  小浜孝士、笹部直子、井上望、橋本哲弥、久保祐貴、巖本三壽、相内敏弘、加藤里奈、板部洋之
- Organizer
  第58回日本脂質生化学会
- Place of Presentation
  秋田
- Year and Date
  2016-06-09
- Data Source
  KAKENHI-PROJECT-15K07944
[Presentation] ヒト血漿から分離した酸化LDLに含まれる酸化リン脂質と変性タンパク質の解析2016
- Author(s)
  笹部直子、小浜孝士、井上望、橋本哲弥、久保祐貴、巖本三壽、相内敏弘、加藤里奈、板部洋之
- Organizer
  衛生薬学・環境トキシロジーフォーラム2016
- Place of Presentation
  東京
- Year and Date
  2016-09-10
- Data Source
  KAKENHI-PROJECT-15K07944

1. ITABE Hiroyuki (30203079)

# of Collaborated Projects: 2 results

# of Collaborated Products: 23 results
2. 小濱孝士 (60395647)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. 山口智広 (50347530)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 加藤里奈 (30392400)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
5. 牧山智彦 (60733102)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
6. OBAMA Takashi

# of Collaborated Projects: 0 results

# of Collaborated Products: 19 results
7. 木庭新治

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

sawada naoko 澤田 直子 (笹部 直子)

澤田 直子 サワダ ナオコ

笹部直子

笹部 直子 ササベ ナオコ

Research Projects

Research Products

Co-Researchers

Oxidatively modified high-density lipoprotein: its roles in vessel wall tissues and mechanism of its generation.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Studies on process of generation and metabolism of oxidized LDL in vivo.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Structure and Dynamics of Oxidized Lipoproteins In Vivo: Roles of High-Density Lipoprotein2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Comparison of protein profiles of the pellicle, gingival crevicular fluid, and saliva: possible origin of pellicle proteins2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Transfer and enzyme-mediated metabolism of oxidized phosphatidylcholine and lysophosphatidylcholine between low- and high-density lipoproteins.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Circulating oxidized LDL increased in patients with acute myocardial infarction is accompanied by heavily modified HDL.2020

Author(s)

Journal Title

Data Source

[Journal Article] Circulating oxidized LDL increased in patients with acute myocardial infarction is accompanied by heavily modified HDL.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cooperative action of oxidized low-density lipoproteins and neutrophils on endothelial inflammatory responses through neutrophil extracellular trap formation2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Significance of oxidized low-density lipoprotein in body fluids as a marker related to diseased conditions.2018

Author(s)

Journal Title

DOI

Data Source

[Presentation] 血中酸化リポタンパク質生成におけるHDLの関わり2020

Author(s)

Organizer

Data Source

[Presentation] Involvement of high-density lipoprotein in oxidatively modified forms of low-density lipoproteins in human circulation.2020

Author(s)

Organizer

Data Source

[Presentation] 血中酸化リポタンパク質生成におけるHDLの関わり。2020

Author(s)

Organizer

Data Source

[Presentation] HDLを伴った血中酸化リポタンパク質粒子の生成と動脈硬化症2020

Author(s)

Organizer

Data Source

[Presentation] 急性心筋梗塞患者血中に増加している酸化HDL-LDL複合体について2019

Author(s)

Organizer

Data Source

[Presentation] Structure and compositional analysis of oxidized low-density lipoproteins present in plasma from healthy subjects and patients with atherosclerosis2019

Author(s)

Organizer

Data Source

[Presentation] 安定同位体リピドミクスを利用したLDL-HDL間の酸化PC代謝解析2019

Author(s)

Organizer

sawada naoko 澤田直子 (笹部直子)

澤田直子サワダナオコ

笹部直子ササベナオコ

[Presentation] 血管内皮細胞の炎症誘導における好中球細胞外トラップと酸化LDLの関与」　日本薬学会第138年会2018