MAGARI Masaki 曲正樹

… Alternative Names

Researcher Number	50359882
Other IDs
Affiliation (Current)	2022: 岡山大学, ヘルスシステム統合科学学域, 助教
Affiliation (based on the past Project Information) *help	2021: 岡山大学, ヘルスシステム統合科学学域, 助教 2018 – 2020: 岡山大学, ヘルスシステム統合科学研究科, 助教 2011 – 2017: 岡山大学, 自然科学研究科, 助教 2014: 岡山大学, 大学院自然科学研究科, 助教 2012: 岡山大学, 大学院・自然科学研究科, 助教 … More
Review Section/Research Field	Principal Investigator Biofunction/Bioprocess / Immunology / Basic Section 27040:Biofunction and bioprocess engineering-related Except Principal Investigator Biofunction/Bioprocess / Basic Section 43030:Functional biochemistry-related / Functional biochemistry / Biofunction/Bioprocess
Keywords	Principal Investigator 濾胞樹状細胞 / 抗体の親和性成熟 / 胚中心 / 親和性成熟 / 体細胞高頻度突然変異 / 抗体遺伝子再構成 / RAG / 蛍光タンパク / レトロウイルスベクター / モノクローナル抗体 … More Except Principal Investigator 抗体 / シグナル伝達 / CaMKK / DT40 / 親和性成熟 / 細胞工学 / AID / 抗体工学 / 変異 / AMPK / タンパク質リン酸化酵素 / 細胞内カルシウム情報伝達 / 体細胞高頻度突然変異 / タンパク質ディスプレー / 濾胞樹状細胞 / 単球系細胞分化 / CSF-1受容体 / IL-34 / CSF-1 / 細胞情報伝達 / 胚中心B細胞 / マイクロRNA / 胚中心B 細胞 / 単球系細胞 / 胚中心Ｂ細胞 / ＣＳＦ－１受容体 / RNAi / 胚中心 / Ｂ細胞 / 骨髄系細胞 / STO-609 / CaMK cascade / Protein Kinase / Signal Transduction / リン酸化反応 / AMPキナーゼ / CaMキナーゼI V / 細胞内カルシウム / 特異性 / CaMK Cascade / バイオテクノロジー / SRタンパク質 / タンパク質リン酸化反応 / タンパク質脱リン酸化反応 / 阻害剤 / TIM-063 / TIM-062 / Ca2+シグナル伝達 / calmodulin / CaMKKβ / PP2A / PP1 / PKA / HeLa細胞 / cAMP / イソプロテレノール / 酵素阻害剤 / キナーゼ阻害剤 / カルモデュリン Less

CaMKKシグナル伝達の制御機構解明とそれに基づく分子標的薬創製
- Principal Investigator
  
  徳光浩
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43030:Functional biochemistry-related
- Research Institution
  Okayama University
リンパ節由来ストローマ細胞株を用いる人工リンパ節構築系の開発Principal Investigator
- Principal Investigator
  
  曲正樹
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 27040:Biofunction and bioprocess engineering-related
- Research Institution
  Okayama University
Estanblishment of cell cuture system to reproduce affinty maturaton of antibyPrincipal Investigator
- Principal Investigator
  
  Magari Masaki
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 27040:Biofunction and bioprocess engineering-related
- Research Institution
  Okayama University
Regulation of CaMKKbeta/AMPK signaling and drug development
- Principal Investigator
  
  Tokumitsu Hiroshi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43030:Functional biochemistry-related
- Research Institution
  Okayama University
Improvement of an animal cell-displaying technology by using a splicing factor
- Principal Investigator
  
  Kanayama Naoki
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biofunction/Bioprocess
- Research Institution
  Okayama University
Phosphorylation-dependent regulatory mechanism of calmoudlin-kinase cascade
- Principal Investigator
  
  Tokumitsu Hiroshi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  Okayama University
Elucidating the activation mechanisms of germinal center B cell induced by monocytic cells depending on follicular dendritic cells.Principal Investigator
- Principal Investigator
  
  Magari Masaki
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Okayama University
Antibody engineering in a hypermutaing B cell line
- Principal Investigator
  
  KANAYAMA NAOKI
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biofunction/Bioprocess
- Research Institution
  Okayama University
Identification of a new type of monocytic cell that promotes affinity maturation and characterization of its B cell-activation mechanism
- Principal Investigator
  
  OHMORI HITOSHI
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biofunction/Bioprocess
- Research Institution
  Okayama University
Analysis of selection mechanisms of germinal center B cells by using a novel follicular dendritic cell linePrincipal Investigator
- Principal Investigator
  
  MAGARI Masaki
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Immunology
- Research Institution
  Okayama University
Establishment of a novel chicken monoclonal antibody generation system for applying to antibody drug development.Principal Investigator
- Principal Investigator
  
  MAGARI Masaki
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biofunction/Bioprocess
- Research Institution
  Okayama University
抗体遺伝子再構成を行ったB細胞を検出する新規可視化法の確立Principal Investigator
- Principal Investigator
  
  曲正樹
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biofunction/Bioprocess
- Research Institution
  Okayama University

[Book] Methods Mol Biol.2019
- Author(s)
  Sakane K, Yamaguchi F, Tsuchiya M, Kondo R, Kanayama N, Magari M, Hatano N, Kobayashi R, Tokumitsu H.
- Total Pages
  11
- Publisher
  Humana Press, New York, NY
- ISBN
  9781493990290
- Data Source
  KAKENHI-PROJECT-18K06113
[Journal Article] Development and Characterization of Novel Molecular Probes for Ca2+/Calmodulin-Dependent Protein Kinase Kinase, Derived from STO-6092020
- Author(s)
  Ohtsuka S, Ozeki Y, Fujiwara M, Miyagawa T, Kanayama N, Magari M, Hatano N, Suizu F, Ishikawa T, and Tokumitsu H.
- Journal Title
  
  Biochemistry
  
  Volume: 59(17) Pages: 1701-1710
- DOI
  10.1021/acs.biochem.0c00149
- NAID
  120007027579
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03447, KAKENHI-PROJECT-18K02255, KAKENHI-PROJECT-18K06113
[Journal Article] Phosphorylation and dephosphorylation of Ca2+/calmodulin-dependent protein kinase kinase β at Thr144 in HeLa cells.2020
- Author(s)
  Takabatake Shota、Fukumoto Yusei、Ohtsuka Satomi、Kanayama Naoki、Magari Masaki、Sakagami Hiroyuki、Hatano Naoya、Tokumitsu Hiroshi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 525 Pages: 251-257
- DOI
  10.1016/j.bbrc.2020.02.056
- NAID
  120006961125
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K02255, KAKENHI-PROJECT-18K06113
[Journal Article] Regulation of Ca2+/calmodulin-dependent protein kinase kinase β by cAMP signaling2019
- Author(s)
  Takabatake S, Ohtsuka S, Sugawara T, Hatano N, Kanayama N, Magari M, Sakagami H, Tokumitsu H.
- Journal Title
  
  Biochimica et Biophysica Acta (BBA) - General Subjects
  
  Volume: 1863 Pages: 672-680
- DOI
  10.1016/j.bbagen.2018.12.012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06113, KAKENHI-PROJECT-15H04196
[Journal Article] Interaction of S100A6 with Target Proteins In Vitro and in Living Cells2019
- Author(s)
  Sakane Kyohei、Yamaguchi Fuminori、Tsuchiya Mitsumasa、Kondo Rina、Kanayama Naoki、Magari Masaki、Hatano Naoya、Kobayashi Ryoji、Tokumitsu Hiroshi
- Journal Title
  
  Methods in Molecular Biology
  
  Volume: 1929 Pages: 367-377
- DOI
  10.1007/978-1-4939-9030-6_23
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04196, KAKENHI-PROJECT-19J12975
[Journal Article] Interleukin 34 (IL-34) cell-surface localization regulated by the molecular chaperone 78-kDa glucose-regulated protein facilitates the differentiation of monocytic cells2018
- Author(s)
  Ogawa Sayaka、Matsuoka Yukiko、Takada Miho、Matsui Kazue、Yamane Fumihiro、Kubota Eri、Yasuhara Shiori、Hieda Kentaro、Kanayama Naoki、Hatano Naoya、Tokumitsu Hiroshi、Magari Masaki
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 294 Pages: 2386-2396
- DOI
  10.1074/jbc.ra118.006226
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K04852, KAKENHI-PROJECT-15H04196
[Journal Article] Identification and characterization of a centrosomal protein, FOR20 as a novel S100A6 target2017
- Author(s)
  Kyohei Sakane, Miyu Nishiguchi, Miwako Denda, Fuminori Yamagchi, Masaki Magari, Naoki Kanayama, Ryo Morishita, Hiroshi Tokumitsu
- Journal Title
  
  Biochemical and biophysical research communications
  
  Volume: 491 Pages: 980-985
- DOI
  10.1016/j.bbrc.2017.07.161
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04196, KAKENHI-PROJECT-16K14783
[Journal Article] SRSF1-3 contributes to diversification of the immunoglobulin variable region gene by promoting accumulation of AID in the nucleus2017
- Author(s)
  Yuka Kawaguchi, Hiroaki Nariki, Naoko Kawamoto, Yuichi Kanehiro, Satoshi Miyazaki, Mari Suzuki, Masaki Magari, Hiroshi Tokumitsu, Naoki Kanayama
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 485 Pages: 261-266
- DOI
  10.1016/j.bbrc.2017.02.097
- NAID
  120006425839
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04196, KAKENHI-PROJECT-16K14783
[Journal Article] AMP-activated protein kinase-mediated feedback phosphorylation controls the Ca2+/calmodulin (CaM) dependence of Ca2+/CaM-dependent protein kinase kinase β2017
- Author(s)
  Akihiro Nakanishi, Naoya Hatano, Yuya Fujiwara, Arian Sha'ri, Shota Takabatake, Hiroki Akano, Naoki Kanayama, Masaki Magari, Naohito Nozaki, Hiroshi Tokumitsu
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 292 Pages: 19804-19813
- DOI
  10.1074/jbc.m117.805085
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04196, KAKENHI-PROJECT-16K14783
[Journal Article] Differential AMP-activated Protein Kinase (AMPK) Recognition Mechanism of Ca2+/Calmodulin-dependent Protein Kinase Kinase Isoforms.2016
- Author(s)
  Yuya Fujiwara, Yoshinori Kawaguchi, Tomohito Fujimoto, Naoki Kanayama, Masaki Magari, Hiroshi Tokumitsu
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 291 Pages: 13802-13808
- DOI
  10.1074/jbc.m116.727867
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H04196, KAKENHI-PROJECT-26440056
[Journal Article] Identification of Striated Muscle Activator of Rho Signaling (STARS) as a Novel Calmodulin Target by a Newly Developed Genome-Wide Screen.2016
- Author(s)
  Yusui Furuya, Miwako Denda, Kyohei Sakane, Tomoko Ogusu, Sumio Takahashi, Masaki Magari, Naoki Kanayama, Ryo Morishita, Hiroshi Tokumitsu
- Journal Title
  
  Cell Calcium
  
  Volume: 60 Pages: 32-40
- DOI
  10.1016/j.ceca.2016.04.004
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H04196, KAKENHI-PROJECT-26440056, KAKENHI-PROJECT-26440167
[Journal Article] Compartmentalized AMPK Signaling Illuminated by Genetically Encoded Molecular Sensors and Actuators2015
- Author(s)
  Miyamoto T, Rho E, Sample V, Akano H, Magari M, Ueno T, Gorshkov K, Chen M, Tokumitsu H, Zhang J, Inoue T
- Journal Title
  
  Cell Reports
  
  Volume: 印刷中
- DOI
  10.1016/j.celrep.2015.03.057
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26440056
[Journal Article] Analysis of Distinct Roles of CaMKK Isoforms Using STO-609-Resistant Mutants in Living Cells2015
- Author(s)
  Fujiwara Y, Hiraoka Y, Fujimoto T, Kanayama N, Magari M, Tokumitsu H.
- Journal Title
  
  Biochemistry
  
  Volume: 54 Pages: 3969-3977
- DOI
  10.1021/acs.biochem.5b00149
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26440056, KAKENHI-PROJECT-15H04196, KAKENHI-PROJECT-26650126
[Journal Article] CSF-1 receptor-mediated differentiation of a new type of monocytic cell with B cell-stimulating activity: its selective dependence on IL-342014
- Author(s)
  Fumihiro Yamane
- Journal Title
  
  Journal of Leukocyte Biology
  
  Volume: 95 Pages: 19-31
- DOI
  10.1189/jlb.0613311
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24360343, KAKENHI-PROJECT-24560961, KAKENHI-PROJECT-25460590
[Journal Article] Activation-induced cytidine deaminase (AID)-dependent somatic hypermuation requires splice isoform of the serine/arginine-rich (SR) protein SRSF12012
- Author(s)
  Kanehiro, Y., Ohmori, H.Kanayama, N., at al
- Journal Title
  
  Proc. Natl. Acad. Sci. USA
  
  Volume: 109 Pages: 1216-1221
- DOI
  10.1073/pnas.1120368109
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21360405, KAKENHI-PROJECT-23657092, KAKENHI-PROJECT-23790537
[Journal Article] 胚中心におけるB細胞のnegative selection と濾胞樹状細胞2012
- Author(s)
  曲正樹
- Journal Title
  
  臨床免疫・アレルギー科
  
  Volume: 58 Pages: 259-265
- Data Source
  KAKENHI-PROJECT-24360343
[Journal Article] 胚中心におけるＢ細胞のnegative selectionと濾胞樹状細胞2012
- Author(s)
  曲　正樹、金山直樹、大森　齊
- Journal Title
  
  臨床免疫・アレルギー科
  
  Volume: 58 Pages: 259-265
- Data Source
  KAKENHI-PROJECT-24560961
[Journal Article] IL-21-dependent B cell death driven by prostaglandin E2, a product secreted from follicular dendritic cells.2011
- Author(s)
  Magari M., Nishikawa Y., Fujii Y., Nishio Y., Watanabe K., Fujiwara M., Kanayama N., Ohmori H.
- Journal Title
  
  The Journal of Immunology
  
  Volume: 187 Pages: 4210-4218
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790537
[Journal Article] IL-21-dependent B cell death driven by prostaglandin E2, a product secreted from follicular dendritic cells2011
- Author(s)
  Magari, M.Ohmori, H., et al
- Journal Title
  
  J. Immunol
  
  Volume: 187 Pages: 4210-4218
- DOI
  10.4049/jimmunol.1100934
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21360405, KAKENHI-PROJECT-22790931, KAKENHI-PROJECT-23790537
[Journal Article] Conditional transformation of immunoglobulin mutation pattern from gene conversion into point mutation by controlling XRCC3 expression in the DT40 B cell line2010
- Author(s)
  Kajita, M., Magari, M., Todo, K., Kanayama, N., Ohmori, H.
- Journal Title
  
  J.Biosci.Bioeng.
  
  Volume: 109 Pages: 407-410
- NAID
  110007618907
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21760641
[Journal Article] Enhancement of hypermutation frequency in the chicken B cell line DT40 for efficient diversification of the antibody repertoire.2010
- Author(s)
  Magari, M., Kanehiro, Y., Todo, K., Ikeda, M., Kanayama, N., Ohmori, H.
- Journal Title
  
  Biochem.Biophys.Res.Commun. 396
  
  Pages: 353-358
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21760641
[Journal Article] Enhancement of hypermutation frequency in the chicken B cell line DT40 for efficient diversification of the antibody repatoire2010
- Author(s)
  Magari, M., Kanehiro, Y., Todo, K., Ikeda, M., Kanayama, N., Ohmori, H.
- Journal Title
  
  Biochem.Biophys.Res.Commun.
  
  Volume: 396 Pages: 353-358
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21760641
[Journal Article] Conditional transformation of immunoglobuline mutation pattern from gene conversion into point mutation by controlling XRCC3 expression in the DT40 B cell line.2010
- Author(s)
  Kajita, M., Magari, M., Todo, K., Kanayama, N., Ohmori, H.
- Journal Title
  
  J.Biosci.Bioeng. 107
  
  Pages: 206-209
- NAID
  110007618907
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21760641
[Journal Article] Efficient affinity maturation of antibodies in an engineered chicken B cell line DT40-SW by increaseing point mutation2010
- Author(s)
  Kajita, M., Okazawa, T., Ikeda, M., Todo, K., Magari, M., Kanayama, N., Ohmori, H.
- Journal Title
  
  J.Biosci.Bioeng.
  
  Volume: 110 Pages: 351-358
- NAID
  110007730029
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21760641
[Journal Article] Conditional transformation of immunoglobulin mutation pattern from gene conversion intopoint mutation by controlling XRCC3 expression in the DT40 B cell line2010
- Author(s)
  Kajita, M., Magari, M., et.al.
- Journal Title
  
  J.Biosci.Bioeng. 109
  
  Pages: 407410-407410
- NAID
  110007618907
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21760641
[Journal Article] Efficient affinity maturation of antibodies in an engineered chicken B cell line DT40-SW by increasing point mutation.2010
- Author(s)
  Kajita, M., Okazawa, T., Ikeda, M., Todo, K., Magari, M., Kanayama, N., Ohmori, H.
- Journal Title
  
  J.Biosci.Bioeng. 110
  
  Pages: 351-358
- NAID
  110007730029
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21760641
[Journal Article] Genetic manipulation of an exogenous non-immunoglobulin protein by gene conversion machinery in a chicken B cell line.2006
- Author(s)
  Kanayama, N., Todo, K., Takahashi, S., Magari, M., Ohmori H.
- Journal Title
  
  Nucleic Acids Research 34・2
- Data Source
  KAKENHI-PROJECT-16760637
[Journal Article] Immunogenicity of autologous IgG bearing the inflammation-associated marker 3-nitrotyrosine.2005
- Author(s)
  Ohmori, H., Oka, M., Nishikawa, Y., Shigemitsu, H., Takeuchi, M., Magari, M., Kanayama, N.
- Journal Title
  
  Immunology Letters 96
  
  Pages: 47-54
- Data Source
  KAKENHI-PROJECT-16760637
[Journal Article] 胚中心におけるB細胞のnegative selectionと濾胞樹状細胞
- Author(s)
  曲正樹、金山直樹、大森斉
- Journal Title
  
  臨床免疫・アレルギー科
  
  Volume: Vol.58(3) Pages: 259-265
- Data Source
  KAKENHI-PROJECT-23790537
[Presentation] 分子プローブとしてのCa2+/calmodulin-dependent protein kinase kinase 新規阻害剤と不活性類縁体の開発2020
- Author(s)
  大塚　里美、尾関　唯、藤原　萌乃、宮川　知之、金山　直樹、曲　正樹、波多野　直哉、石川　彰彦、徳光　浩
- Organizer
  第６１回日本生化学会中国・四国支部例会
- Data Source
  KAKENHI-PROJECT-18K06113
[Presentation] 濾胞樹状細胞依存的分化するB細胞活性化能力を有した単球系細胞の分化機構の解析2020
- Author(s)
  曲正樹，小川紗也香，岡本千怜，西岡美玖，金山直樹，波多野直哉，徳光浩
- Organizer
  第43回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K04852
[Presentation] 濾胞樹状細胞の発現するSLAM-family memberによる胚中心反応の制御2020
- Author(s)
  西岡美玖，西岡美穂，小川紗也香，金山直樹，波多野直哉，徳光浩，曲正樹
- Organizer
  第43回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K04852
[Presentation] 濾胞樹状細胞の発現するIL-34がB細胞活性化能力を有する単球系細胞の分化に関与する2019
- Author(s)
  曲正樹、小川紗也香、松岡由希子、高田美帆、金山直樹、波多野直哉、徳光浩
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K04852
[Presentation] CaMKKβのリン酸化/脱リン酸化による動的制御機構の解明2019
- Author(s)
  高畠　翔太、福本　侑世、金山　直樹、曲　正樹、波多野　直哉、徳光　浩
- Organizer
  第39回　日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K06113
[Presentation] 濾胞樹状細胞の活性化に伴い高発現する分子の探索とその機能解析2019
- Author(s)
  西岡美玖、西岡美穂、小川紗也香、波多野直哉、金山直樹、徳光浩、曲正樹
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K04852
[Presentation] 濾胞樹状細胞が発現するIL-34の免疫学的作用についての解析2018
- Author(s)
  松岡由希子，小川紗也香，安原詩織，金山直樹，徳光浩，曲正樹
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K04852
[Presentation] スプライシング因子の過剰発現及び標的遺伝子配列の操作によるニワトリ B 細胞株における遺伝子変異の増強2018
- Author(s)
  金山直樹, 太田愛美, 西山由美子, 岡知里, 曲正樹, 徳光浩
- Organizer
  第70回日本生物工学会大会
- Data Source
  KAKENHI-PROJECT-15H04196
[Presentation] CaMKKβシグナル伝達のAMPKおよびPKAによるリン酸化制御機構の解明2018
- Author(s)
  大塚里美, 高畠翔太, 金山直樹, 曲正樹, 徳光浩
- Organizer
  第９１回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-18K06113
[Presentation] 濾胞樹状細胞により誘導される単球系細胞によるB細胞活性化メカニズムの解明2018
- Author(s)
  高田美帆，鳥家雄二，稗田健太郎，金山直樹，徳光浩，曲正樹
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K04852
[Presentation] GRP78により発現制御される濾胞樹状細胞表面のIL-34が単球系細胞の分化に関与する2018
- Author(s)
  小川紗也香，松岡由希子，高田美帆，松井一恵，山根文寛，安原詩織，金山直樹，波多野直哉，徳光浩，曲正樹
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K04852
[Presentation] 濾胞樹状細胞による抗体の親和性成熟の制御機構の解明2018
- Author(s)
  曲正樹，小川紗也香，松岡由希子，高田美帆，金山直樹，徳光浩
- Organizer
  第56回日本生物物理学会年会
- Data Source
  KAKENHI-PROJECT-18K04852
[Presentation] 濾胞樹状細胞が発現するIL-34の免疫学的作用についての解析2018
- Author(s)
  松岡由希子, 小川紗也香, 安原詩織, 金山直樹, 德光浩, 曲正樹
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-15H04196
[Presentation] GRP78により発現制御される濾胞樹状細胞表面のIL-34が単球系細胞の分化に関与する2018
- Author(s)
  小川紗也香, 松岡由希子, 高田美帆, 松井一恵, 山根文寛, 安原詩織, 金山直樹, 波多野直哉, 徳光浩, 曲正樹
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-15H04196
[Presentation] 濾胞樹状細胞により誘導される単球系細胞によるB細胞活性化メカニズムの解明2018
- Author(s)
  高田美帆, 鳥家雄二, 稗田健太郎, 金山直樹, 德光浩, 曲正樹
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-15H04196
[Presentation] CaMKKβシグナル伝達のAMPKおよびPKAによるリン酸化制御機構の解明2018
- Author(s)
  大塚里美, 高畠翔太, 金山直樹, 曲正樹, 徳光浩
- Organizer
  第91回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-15H04196
[Presentation] AID発現とSHM誘導におけるBCRシグナルの役割2017
- Author(s)
  梶浦雄也、金廣優一、曲正樹、徳光浩、金山直樹
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-15H04196
[Presentation] 抗体遺伝子変異能力を操作できるニワトリB細胞を用いた動物細胞ディスプレイ2017
- Author(s)
  金山直樹, 太田愛美, 西山由美子, 清木俊雄, 植月英智, 川口祐加, 仲尾祐輝, 曲正樹, 徳光浩
- Organizer
  第69回日本生物工学会大会
- Data Source
  KAKENHI-PROJECT-15H04196
[Presentation] スプライシング因子の過剰発現及び標的遺伝子配列の操作によるニワトリB細胞株における遺伝子変異の増強2017
- Author(s)
  太田愛美、西山由美子、曲正樹、徳光浩、金山直樹
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-15H04196
[Presentation] 抗体遺伝子変異の転写関連過程におけるSRSF1-3の役割の解析2017
- Author(s)
  金山直樹、川口祐加、横山和輝、石橋朋之、曲正樹、徳光浩
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-15H04196
[Presentation] SRSF1-3の高度保存領域が抗体遺伝子変異に寄与する2016
- Author(s)
  成木弘明、川口祐加、宮崎誠士、河本奈緒子、横山和輝、徳光浩、曲正樹、金山直樹
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-12-02
- Data Source
  KAKENHI-PROJECT-15H04196
[Presentation] 抗体遺伝子高頻度突然変異におけるssDNA形成へのSRSF1-3の関与の解析2016
- Author(s)
  横山和輝、川口祐加、松山雄磨、河本奈緒子、成木弘明、徳光浩、曲正樹、金山直樹
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-12-02
- Data Source
  KAKENHI-PROJECT-15H04196
[Presentation] スプライシング因子過剰発現による B 細胞株における抗体遺伝子変異の増強2016
- Author(s)
  太田愛美, 西山由美子, 清木俊雄, 植月英智, 川口祐加, 仲尾祐輝, 曲正樹, 徳光浩, 金山直樹
- Organizer
  第68回日本生物工学会大会
- Place of Presentation
  富山国際会議場（富山県富山市）
- Year and Date
  2016-09-29
- Data Source
  KAKENHI-PROJECT-15H04196
[Presentation] 抗体遺伝子変異における転写依存性過程におけるSRSF1-3の役割の解析2016
- Author(s)
  川口祐加、横山和輝、河本奈緒子、成木弘明、松山雄磨、金廣優一、曲正樹、大森斉、徳光浩、金山直樹
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-12-02
- Data Source
  KAKENHI-PROJECT-15H04196
[Presentation] Ca2+/Calmodulin-dependent Protein Kinase Kinaseシグナル伝達機構の茶道原理の解明（基質認識機構）2016
- Author(s)
  藤原侑哉、川口義典、藤本智仁、金山直樹、曲正樹、徳光浩
- Organizer
  第３９回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-26440056
[Presentation] AID発現とSHM誘導におけるBCRシグナルの役割2016
- Author(s)
  梶浦　雄也、金廣　優一、有年　由貴子、曲　正樹、徳光　浩、金山　直樹
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-12-02
- Data Source
  KAKENHI-PROJECT-15H04196
[Presentation] COMPREHENSIVE IDENTIFICATION OF HUMAN CALMODULIN-TARGETS2015
- Author(s)
  Furuya Y, Denda M, Kanayama N, Magari M, Morishita R, Tokumitsu H
- Organizer
  19th International Symposium on Calcium Binding Proteins and Calcium Function In Health and Disease
- Place of Presentation
  ナッシュビル・アメリカ
- Year and Date
  2015-05-30
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26440056
[Presentation] Ca2+/Calmodulin結合型転写因子の網羅的同定2015
- Author(s)
  太尾田　泰成、大西　和貴、古谷　雄穂、傳田　美和子、金山　直樹、曲　正樹、森下　了、徳光　浩
- Organizer
  第38回日本分子生物学会年会第88回日本生化学会大会　合同大会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26440056
[Presentation] ANALYSIS OF DISTINCT ROLES OF CAMKK ISOFORMS USING STO-609- RESISTANT MUTANTS IN LIVING CELLS2015
- Author(s)
  Fujiwara Y, Hiraoka Y, Fujimoto T, Kanayama N, Magari M, Tokumitsu H
- Organizer
  19th International Symposium on Calcium Binding Proteins and Calcium Function In Health and Disease
- Place of Presentation
  ナッシュビル・アメリカ
- Year and Date
  2015-05-30
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26440056
[Presentation] ニワトリSRSF1-3の抗体遺伝子変異における機能部位の探索2015
- Author(s)
  155成木弘明, 川口祐加, 宮崎誠士, 河本奈緒子, 横山和輝, 徳光浩, 曲正樹, 金山直樹
- Organizer
  BMB2015
- Place of Presentation
  神戸国際会議場･展示場
- Year and Date
  2015-12-02
- Data Source
  KAKENHI-PROJECT-15H04196
[Presentation] IL-34/CSF-1R-dependent generation of a novel class of monocytic cells with unique B cell-stimulating activities2015
- Author(s)
  MAGARI Masaki, OGAWA Sayaka, TOYA Yuji, HIEDA Kentaro, YAMANE Fumihiro, MATSUI Kazue, NISHIKAWA Yumiko, KANAYAMA Naoki, TOKUMITSU Hiroshi, OHMORI Hitoshi
- Organizer
  The 44th Annual Meeting of The Japanese Society of Immunology
- Place of Presentation
  札幌
- Year and Date
  2015-11-18
- Data Source
  KAKENHI-PROJECT-25460590
[Presentation] 濾胞樹状細胞依存的に発生する新規単球系細胞の分化機構の解明; CSF-1Rに作用するIL-34特異的作用の解析2015
- Author(s)
  小川紗也香，山根文寛，松井一恵，稗田健太郎，西川裕美子，金山直樹，德光浩，大森斉，曲正樹
- Organizer
  第38回日本分子生物学会年会・第88回日本生化学会大会　合同大会
- Place of Presentation
  神戸
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25460590
[Presentation] ニワトリB細胞株DT40におけるヒト型抗体の産生増強2015
- Author(s)
  中谷耕治, 檀上悟史, 曲正樹, 徳光浩, 金山直樹
- Organizer
  第67回日本生物工学会大会
- Place of Presentation
  鹿児島市
- Year and Date
  2015-10-27
- Data Source
  KAKENHI-PROJECT-15H04196
[Presentation] CaMKKβによる選択的AMPK活性化の細胞生物学的および生化学的解析2015
- Author(s)
  藤原　侑哉、川口　義典、藤本　智仁、曲　正樹、金山　直樹、徳光　浩
- Organizer
  第38回日本分子生物学会年会第88回日本生化学会大会　合同大会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26440056
[Presentation] ニワトリ B 細胞株における BCR シグナル依存性アポトーシスの制御による高親和性抗体の作製2015
- Author(s)
  金山直樹, 古賀舞, 池田美香, 小嶋宏侑, 曲正樹, 徳光浩, 大森斉
- Organizer
  第67回日本生物工学会大会
- Place of Presentation
  鹿児島市
- Year and Date
  2015-10-27
- Data Source
  KAKENHI-PROJECT-15H04196
[Presentation] 濾胞樹状細胞依存的に誘導される単球系細胞により活性化された胚中心B細胞の機能解析2015
- Author(s)
  曲正樹，鳥家雄二，長尾峻久，小川紗也香，稗田健太郎，岩崎映理子，西川裕美子，金山直樹，德光浩，大森斉
- Organizer
  第38回日本分子生物学会年会・第88回日本生化学会大会　合同大会
- Place of Presentation
  神戸
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25460590
[Presentation] ヒトCalmodulin標的分子の網羅的同定2014
- Author(s)
  古谷　雄穂, 西口　みゆ, 傳田美和子, 曲正樹，金山直樹，森下　了, 徳光浩
- Organizer
  第８７回日本生化学会大会
- Place of Presentation
  京都
- Year and Date
  2014-10-18
- Data Source
  KAKENHI-PROJECT-26440056
[Presentation] 変異能力を備えた B 細胞株を用いた抗体の機能改変2014
- Author(s)
  金山直樹 , 渡邊康二 , 古賀舞 , 川上夏奈江 , 植月英智 , 徳光浩 , 曲正樹 , 大森斉
- Organizer
  第６６回日本生物工学会大会
- Place of Presentation
  札幌コンベンションセンター
- Year and Date
  2014-09-11
- Data Source
  KAKENHI-PROJECT-24360343
[Presentation] STO-609抵抗性変異体を用いたCaMKKシグナル伝達の機能解析2014
- Author(s)
  藤原　侑哉, 平岡　佑理, 曲正樹，金山直樹，徳光浩
- Organizer
  第８７回日本生化学会大会
- Place of Presentation
  京都
- Year and Date
  2014-10-17
- Data Source
  KAKENHI-PROJECT-26440056
[Presentation] 抗原レセプターシグナル依存性アポトーシス因子を抑制したニワトリB細胞株を用いた高親和性抗体の作製2014
- Author(s)
  古賀舞, 池田美香, 小嶋宏侑, 曲正樹, 徳光浩, 大森斉, 金山直樹
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-11-25
- Data Source
  KAKENHI-PROJECT-24360343
[Presentation] Follicular dendritic cells induce a new class of myeloid cells with unique B cell stimulating activities: specific dependence on IL-34/CSF-1R signaling pathway.2013
- Author(s)
  Yamane, F., Nishikawa, Y., Matsui, K., Asakura, M., Iwasaki, E., Watanabe, K., Tanimoto, H., Sano, H., Fujiwara, Y., Stanley, E. R., Kanayama, N., Mabbott, N. A., Magari, M., Ohmori, H.
- Organizer
  15th International Congress of Immunology
- Place of Presentation
  ミラノ（イタリア）
- Data Source
  KAKENHI-PROJECT-24560961
[Presentation] Follicular dendritic cells induce a new class of myeloid cells with B cell stimulating activities: specific dependence on Il-34/CSF-1R signaling pathway.2013
- Author(s)
  Yamane F., Matsui, K., Tanimoto, H., Iwasaki, E., Asakura, M., Tokumitsu, H., Nishikawa, Y., Kanayama, N., Magari, M., Ohmori, H.
- Organizer
  15th International Congress of Immunology
- Place of Presentation
  ミラノ（イタリア）
- Data Source
  KAKENHI-PROJECT-25460590
[Presentation] IL-34-dependent monocytic cells that promote centroblast-associated phenotype expression in mouse activated B cells2012
- Author(s)
  Magari Masaki et al
- Organizer
  2012 日本免疫学会総会・学術集会
- Place of Presentation
  神戸
- Year and Date
  2012-12-06
- Data Source
  KAKENHI-PROJECT-23790537
[Presentation] IL-34-dependent monocytic cells that promote centroblast-associated phenotype expression in mouse activated B cells2012
- Author(s)
  曲　正樹、大森　齊他９名
- Organizer
  日本免疫学会総会
- Place of Presentation
  神戸国際会議場
- Data Source
  KAKENHI-PROJECT-24560961
[Presentation] 、IL-21 依存的な胚中心 B 細胞死は FDC より産生されるプロスタグラジン E2により誘導される2011
- Author(s)
  曲正樹他
- Organizer
  2011 免疫学会総会・学術集会
- Place of Presentation
  千葉
- Year and Date
  2011-11-28
- Data Source
  KAKENHI-PROJECT-23790537
[Presentation] IL-34 依存的に発生する新規ミエロイド系細胞;IL-34 と M-CSF の異なる作用2011
- Author(s)
  曲正樹他
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2011-12-14
- Data Source
  KAKENHI-PROJECT-23790537
[Presentation] IL-21-dependent germinal center B cell death driven by prostaglandin E2, a product secreted from follicular dendritic cells.2011
- Author(s)
  MAGARI M., FUJII Y., NISHIO Y., WATANABE K., NISHIKAWA Y., KANAYAMA N., OHMORI H.
- Organizer
  第40回日本免疫学会学術総会
- Place of Presentation
  千葉
- Data Source
  KAKENHI-PROJECT-23790537
[Presentation] Affinity maturation of a mouse monoclonal antibody in an in vitro antibody generation system using the hypermutating chicken B cell line2010
- Author(s)
  N.Kanayama, S.Kojima, S.Fujii, K.Kitamura, K.Inoue, N.Okayama, S.Matsuda, Y.Kanehiro, K.Todo, M.Magari, H.Ohmori
- Organizer
  14^<th> International Congress of Immunology
- Place of Presentation
  Kobe
- Data Source
  KAKENHI-PROJECT-21760641
[Presentation] DT40-SWを用いるin vitro抗体作製システムの高機能化:遺伝子変換と点突然変異の転換システムの構築2009
- Author(s)
  曲正樹、梶田真道、金山直樹、大森斉
- Organizer
  第61回日本生物工学会大会
- Place of Presentation
  名古屋
- Year and Date
  2009-09-24
- Data Source
  KAKENHI-PROJECT-21760641
[Presentation] IL-34依存的に発生する新規単球系細胞の分化機構；濾胞樹状細胞によるIL-34特異的作用の解析
- Author(s)
  小川紗也香，大森斉，曲正樹　他６名
- Organizer
  第３７回日本分子生物学会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2014-12-01 – 2014-12-04
- Data Source
  KAKENHI-PROJECT-24560961
[Presentation] IL-34-dependent monocytic cells that promote centroblast-associated phenotype expression in mouse activated B cells.
- Author(s)
  Magari Masaki
- Organizer
  2012 日本免疫学会総会・学術集会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-23790537
[Presentation] IL-34依存的に発生する新規単球系細胞の分化機構；濾胞樹状細胞によるIL-34特異的作用の解析
- Author(s)
  小川紗也香，山根文寛，松井一恵，鳥家雄二，西川裕美子，德光浩，金山直樹，大森斉，曲正樹
- Organizer
  第37回日本分子生物学会
- Place of Presentation
  横浜
- Year and Date
  2014-12-01 – 2014-12-04
- Data Source
  KAKENHI-PROJECT-25460590
[Presentation] 濾胞樹状細胞依存的に発生する新規単球系細胞による胚中心B細胞の活性化
- Author(s)
  鳥家雄二，長尾峻久，小川紗也香，岩崎映理子，松井一恵，西川裕美子，金山直樹，德光浩，大森斉，曲正樹
- Organizer
  第37回日本分子生物学会
- Place of Presentation
  横浜
- Year and Date
  2014-12-01 – 2014-12-04
- Data Source
  KAKENHI-PROJECT-25460590

1. Tokumitsu Hiroshi (20237077)

# of Collaborated Projects: 4 results

# of Collaborated Products: 38 results
2. KANAYAMA NAOKI (70304334)

# of Collaborated Projects: 2 results

# of Collaborated Products: 30 results
3. OHMORI HITOSHI (70116440)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. HATANO Naoya (10332280)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
5. 石川彰彦 (10263617)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 渡辺泰男 (10273228)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. SUIZU Futoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. GU TinTin

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 大森斉

# of Collaborated Projects: 0 results

# of Collaborated Products: 7 results
10. 高橋純夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

MAGARI Masaki 曲 正樹

曲 正樹 マガリ マサキ

Research Projects

Research Products

Co-Researchers

CaMKKシグナル伝達の制御機構解明とそれに基づく分子標的薬創製

Principal Investigator

Project Period (FY)

Research Category

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リンパ節由来ストローマ細胞株を用いる人工リンパ節構築系の開発Principal Investigator

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Estanblishment of cell cuture system to reproduce affinty maturaton of antibyPrincipal Investigator

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Regulation of CaMKKbeta/AMPK signaling and drug development

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Improvement of an animal cell-displaying technology by using a splicing factor

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Phosphorylation-dependent regulatory mechanism of calmoudlin-kinase cascade

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Elucidating the activation mechanisms of germinal center B cell induced by monocytic cells depending on follicular dendritic cells.Principal Investigator

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Antibody engineering in a hypermutaing B cell line

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Identification of a new type of monocytic cell that promotes affinity maturation and characterization of its B cell-activation mechanism

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Analysis of selection mechanisms of germinal center B cells by using a novel follicular dendritic cell linePrincipal Investigator

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Establishment of a novel chicken monoclonal antibody generation system for applying to antibody drug development.Principal Investigator

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抗体遺伝子再構成を行ったB細胞を検出する新規可視化法の確立Principal Investigator

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[Book] Methods Mol Biol.2019

Author(s)

Total Pages

MAGARI Masaki 曲正樹

曲正樹マガリマサキ